142 results on '"Barnabas, Shaun L."'
Search Results
2. ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19
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Kaplonek, Paulina, Cizmeci, Deniz, Kwatra, Gaurav, Izu, Alane, Lee, Jessica Shih-Lu, Bertera, Harry L., Fischinger, Stephanie, Mann, Colin, Amanat, Fatima, Wang, Wenjun, Koen, Anthonet L., Fairlie, Lee, Cutland, Clare L., Ahmed, Khatija, Dheda, Keertan, Barnabas, Shaun L., Bhorat, Qasim Ebrahim, Briner, Carmen, Krammer, Florian, Saphire, Erica Ollman, Gilbert, Sarah C., Lambe, Teresa, Pollard, Andrew J., Nunes, Marta, Wuhrer, Manfred, Lauffenburger, Douglas A., Madhi, Shabir A., and Alter, Galit
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- 2023
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3. Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial.
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Balle, Christina, Konstantinus, Iyaloo N, Jaumdally, Shameem Z, Havyarimana, Enock, Lennard, Katie, Esra, Rachel, Barnabas, Shaun L, Happel, Anna-Ursula, Moodie, Zoe, Gill, Katherine, Pidwell, Tanya, Karaoz, Ulas, Brodie, Eoin, Maseko, Venessa, Gamieldien, Hoyam, Bosinger, Steven E, Myer, Landon, Bekker, Linda-Gail, Passmore, Jo-Ann S, and Jaspan, Heather B
- Subjects
Vagina ,T-Lymphocytes ,Humans ,HIV Infections ,Norethindrone ,Contraceptives ,Oral ,Combined ,RNA ,Ribosomal ,16S ,Cytokines ,Cross-Over Studies ,Contraceptive Devices ,Female ,Adolescent ,Africa South of the Sahara ,Female ,Young Adult ,Microbiota ,Hormonal Contraception ,Contraceptives ,Oral ,Combined ,RNA ,Ribosomal ,16S ,Contraceptive Devices - Abstract
Young women in sub-Saharan Africa are disproportionally affected by HIV infection and unintended pregnancies. However, hormonal contraceptive (HC) use may influence HIV risk through changes in genital tract microbiota and inflammatory cytokines. To investigate this, 130 HIV negative adolescent females aged 15-19 years were enrolled into a substudy of UChoose, an open-label randomized crossover study (NCT02404038), comparing acceptability and contraceptive product preference as a proxy for HIV prevention delivery methods. Participants were randomized to injectable norethisterone enanthate (Net-En), combined oral contraceptives (COC) or etonorgesterol/ethinyl estradiol combined contraceptive vaginal ring (CCVR) for 16 weeks, then crossed over to another HC for 16 weeks. Cervicovaginal samples were collected at baseline, crossover and exit for characterization of the microbiota and measurement of cytokine levels; primary endpoints were cervical T cell activation, vaginal microbial diversity and cytokine concentrations. Adolescents randomized to COCs had lower vaginal microbial diversity and relative abundance of HIV risk-associated taxa compared to Net-En or CCVR. Cervicovaginal inflammatory cytokine concentrations were significantly higher in adolescents randomized to CCVR compared to COC and Net-En. This suggests that COC use may induce an optimal vaginal ecosystem by decreasing bacterial diversity and inflammatory taxa, while CCVR use is associated with genital inflammation.
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- 2020
4. Pharmacokinetics, safety, and tolerability of dispersible and immediate-release abacavir, dolutegravir, and lamivudine tablets in children with HIV (IMPAACT 2019): week 24 results of an open-label, multicentre, phase 1–2 dose-confirmation study
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Brooks, Kristina M, Kiser, Jennifer J, Ziemba, Lauren, Ward, Shawn, Rani, Yasha, Cressey, Tim R, Masheto, Gaerolwe R, Cassim, Haseena, Deville, Jaime G, Ponatshego, Ponego L, Patel, Faeezah, Aurpibul, Linda, Barnabas, Shaun L, Mustich, Iris, Coletti, Anne, Heckman, Barbara, Krotje, Chelsea, Lojacono, Mark, Yin, Dwight E, Townley, Ellen, Moye, Jack, Majji, Sai, Acosta, Edward P, Ryan, Kevin, Chandasana, Hardik, Brothers, Cynthia H, Buchanan, Ann M, Rabie, Helena, and Flynn, Patricia M
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- 2023
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5. Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysis of a randomised, phase 1b–2a trial
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Madhi, Shabir A, Kwatra, Gaurav, Richardson, Simone I, Koen, Anthonet L, Baillie, Vicky, Cutland, Clare L, Fairlie, Lee, Padayachee, Sherman D, Dheda, Keertan, Barnabas, Shaun L, Bhorat, Qasim Ebrahim, Briner, Carmen, Ahmed, Khatija, Aley, Parvinder K, Bhikha, Sutika, Bhorat, A E, Esmail, Aliasgar, Horne, Elizea, Kaldine, Haajira, Mukendi, Christian K, Madzorera, Vimbai Sharon, Manamela, Nelia P, Masilela, Mduduzi, Hermanus, S Tandile, Motlou, Thopisang, Mzindle, Nonkululeko, Oelofse, Suzette, Patel, Faeezah, Rhead, Sarah, Rossouw, Lindie, Taoushanis, Carol, van Eck, Samuel, Lambe, Teresa, Gilbert, Sarah C, Pollard, Andrew J, Moore, Penny L, and Izu, Alane
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- 2023
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6. The effect of oral iron supplementation on the gut microbiota, gut inflammation, and iron status in iron-depleted South African school-age children with virally suppressed HIV and without HIV
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Goosen, Charlene, Proost, Sebastian, Tito, Raul Y., Baumgartner, Jeannine, Barnabas, Shaun L., Cotton, Mark F., Zimmermann, Michael B., Raes, Jeroen, and Blaauw, Renée
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- 2022
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7. Efficacy, Safety, and Immunogenicity of the MATISSE (Maternal Immunization Study for Safety and Efficacy) Maternal Respiratory Syncytial Virus Prefusion F Protein Vaccine Trial.
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Simões, Eric A. F., Pahud, Barbara A., Madhi, Shabir A., Kampmann, Beate, Shittu, Emma, Radley, David, Llapur, Conrado, Baker, Jeffrey, Pérez Marc, Gonzalo, Barnabas, Shaun L., Fausett, Merlin, Adam, Tyler, Perreras, Nicole, Van Houten, Marlies A., Kantele, Anu, Huang, Li-Min, Bont, Louis J., Otsuki, Takeo, Vargas, Sergio L., and Gullam, Joanna
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- 2025
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8. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in people living with and without HIV in South Africa: an interim analysis of a randomised, double-blind, placebo-controlled, phase 1B/2A trial
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Madhi, Shabir A, Koen, Anthonet L, Izu, Alane, Fairlie, Lee, Cutland, Clare L, Baillie, Vicky, Padayachee, Sherman D, Dheda, Keertan, Barnabas, Shaun L, Bhorat, Qasim Ebrahim, Briner, Carmen, Aley, Parvinder K, Bhikha, Sutika, Hermanus, Tandile, Horne, Elizea, Jose, Aylin, Kgagudi, Prudence, Lambe, Teresa, Masenya, Masebole, Masilela, Mduduzi, Mkhize, Nonhlanhla, Moultrie, Andrew, Mukendi, Christian K, Moyo-Gwete, Thandeka, Nana, Amit J, Nzimande, Ayanda, Patel, Faeezah, Rhead, Sarah, Taoushanis, Carol, Thombrayil, Asha, van Eck, Samuel, Voysey, Merryn, Villafana, Tonya L, Vekemans, Johan, Gilbert, Sarah C, Pollard, Andrew J, Moore, Penny L, and Kwatra, Gaurav
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- 2021
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9. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
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Aban, Marites, Abeyskera, Kushala W.M., Aboagye, Jeremy, Adam, Matthew, Adams, Kirsty, Adamson, James P., Adewatan, Gbadebo, Adlou, Syed, Ahmed, Khatija, Akhalwaya, Yasmeen, Akhalwaya, Saajida, Alcock, Andrew, Ali, Aabidah, Allen, Elizabeth R., Allen, Lauren, Alvernaz, Felipe B., Amorim, Fabio Santos, Andrade, Claudia Sala, Andritsou, Foteini, Anslow, Rachel, Arbe-Barnes, Edward H., Ariaans, Mark P., Arns, Beatriz, Arruda, Laiana, Assad, Luiza, Azi, Paula De Almeida, Azi, Lorena De Almeida, Babbage, Gavin, Bailey, Catherine, Baker, Kenneth F., Baker, Megan, Baker, Natalie, Baker, Philip, Baleanu, Ioana, Bandeira, Danieli, Bara, Anna, Barbosa, Marcella A.S., Barker, Debbie, Barlow, Gavin D., Barnes, Eleanor, Barr, Andrew S., Barrett, Jordan R., Barrett, Jessica, Barrett, Kelly, Bates, Louise, Batten, Alexander, Beadon, Kirsten, Beales, Emily, Beckley, Rebecca, Belij-Rammerstorfer, Sandra, Bell, Jonathan, Bellamy, Duncan, Belton, Sue, Berg, Adam, Bermejo, Laura, Berrie, Eleanor, Berry, Lisa, Berzenyi, Daniella, Beveridge, Amy, Bewley, Kevin R., Bharaj, Inderjeet, Bhikha, Sutika, Bhorat, Asad E., Bhorat, Zaheda E., Bijker, Else Margreet, Birch, Sarah, Birch, Gurpreet, Birchall, Kathryn, Bird, Adam, Bird, Olivia, Bisnauthsing, Karen, Bittaye, Mustapha, Blackwell, Luke, Blacow, Rachel, Bletchly, Heather, Blundell, Caitlin L., Blundell, Susannah R., Bodalia, Pritesh, Bolam, Emma, Boland, Elena, Bormans, Daan, Borthwick, Nicola, Bowring, Francesca, Boyd, Amy, Bradley, Penny, Brenner, Tanja, Bridges-Webb, Alice, Brown, Phillip, Brown, Claire, Brown-O'Sullivan, Charlie, Bruce, Scott, Brunt, Emily, Budd, William, Bulbulia, Yusuf A., Bull, Melanie, Burbage, Jamie, Burn, Aileen, Buttigieg, Karen R., Byard, Nicholas, Cabrera Puig, Ingrid, Calvert, Anna, Camara, Susana, Cao, Michelangelo, Cappuccini, Federica, Cardona, Rita, Cardoso, João R., Carr, Melanie, Carroll, Miles W., Carson-Stevens, Andrew, Carvalho, Yasmin de M., Casey, Helen R., Cashen, Paul, Castro, Thais R.Y., Castro, Lucia Carratala, Cathie, Katrina, Cavey, Ana, Cerbino-Neto, José, Cezar, Luiz Fernando F., Chadwick, Jim, Chanice, Chanice, Chapman, David, Charlton, Sue, Cheliotis, Katerina S., Chelysheva, Irina, Chester, Oliver, Chiplin, Emily, Chita, Sunder, Cho, Jee-Sun, Cifuentes, Liliana, Clark, Elizabeth, Clark, Matthew, Colin-Jones, Rachel, Collins, Sarah L.K., Colton, Hayley, Conlon, Christopher P., Connarty, Sean, Coombes, Naomi, Cooper, Cushla, Cooper, Rachel, Cornelissen, Lynne, Corrah, Tumena, Cosgrove, Catherine A., Costa, Fernanda Barroso, Cox, Tony, Crocker, Wendy E.M., Crosbie, Sarah, Cullen, Dan, Cunha, Debora R.M.F., Cunningham, Christina J., Cuthbertson, Fiona C., da Costa, Daniel Marinho, Da Guarda, Suzete N. Farias, da Silva, Larissa P., da Silva Moraes, Antonio Carlos, Damratoski, Brad E., Danos, Zsofia, Dantas, Maria T.D.C., Datoo, Mehreen S., Datta, Chandrabali, Davids, Malika, Davies, Sarah L., Davies, Kelly, Davies, Hannah, Davies, Sophie, Davies, Judith, Davis, Elizabeth J., Davis, John, de Carvalho, José A.M., De Jager, Jeanne, de Jesus Jnr, Sergio, De Oliveira Kalid, Lis Moreno, Dearlove, David, Demissie, Tesfaye, Desai, Amisha, Di Marco, Stefania, Di Maso, Claudio, Dinesh, Tanya, Docksey, Claire, Dong, Tao, Donnellan, Francesca R., Dos Santos, Tannyth Gomes, Dos Santos, Thainá G., Dos Santos, Erika Pachecho, Douglas, Naomi, Downing, Charlotte, Drake, Jonathan, Drake-Brockman, Rachael, Drury, Ruth, Du Plessis, Joan, Dunachie, Susanna J., Duncan, Andrew, Easom, Nicholas J.W., Edwards, Mandy, Edwards, Nick J., Edwards, Frances, El Muhanna, Omar M., Elias, Sean C., Ellison-Handley, Branwen, Elmore, Michael J., English, Marcus Rex, Esmail, Alisgair, Essack, Yakub Moosa, Farooq, Mutjaba, Fedosyuk, Sofiya, Felle, Sally, Ferguson, Susie, Ferreira Da Silva, Carla, Field, Samantha, Fisher, Richard, Fletcher, James, Fofie, Hazel, Fok, Henry, Ford, Karen J., Fothergill, Ross, Fowler, Jamie, Fraiman, Pedro H.A., Francis, Emma, Franco, Marilia M., Frater, John, Freire, Marilúcia S.M., Fry, Samantha H., Fudge, Sabrina, Furlan Filho, Renato, Furze, Julie, Fuskova, Michelle, Galian-Rubio, Pablo, Garlant, Harriet, Gavrila, Madita, Gibbons, Karyna A., Gilbride, Ciaran, Gill, Hardeep, Godwin, Kerry, Gokani, Karishma, Gonçalves, Maria Luisa Freire, Gonzalez, Isabela G.S., Goodall, Jack, Goodwin, Jayne, Goondiwala, Amina, Gordon-Quayle, Katherine, Gorini, Giacomo, Goyanna, Alvaro, Grab, Janet, Gracie, Lara, Green, Justin, Greenwood, Nicola, Greffrath, Johann, Groenewald, Marisa M., Gunawardene, Anishka, Gupta, Gaurav, Hackett, Mark, Hallis, Bassam, Hamaluba, Mainga, Hamilton, Elizabeth, Hamlyn, Joseph, Hammersley, Daniel, Hanrath, Aidan T., Hanumunthadu, Brama, Harris, Stephanie A., Harris, Clair, Harrison, Thomas D., Harrison, Daisy, Harris-Wright, Tara A., Hart, Thomas C., Hartnell, Birgit, Haughney, John, Hawkins, Sophia, Hayano, Laís Y.M., Head, Ian, Heath, Paul T., Henry, John Aaron, Hermosin Herrera, Macarena, Hettle, David B., Higa, Cristhiane, Hill, Jennifer, Hodges, Gina, Hodgson, Susanne, Horne, Elizea, Hou, Mimi M., Houlihan, Catherine F., Howe, Elizabeth, Howell, Nicola, Humphreys, Jonathan, Humphries, Holly E., Hurley, Katrina, Huson, Claire, Hyams, Catherine, Hyder-Wright, Angela, Ikram, Sabina, Ishwarbhai, Alka, Iveson, Poppy, Iyer, Vidyashankara, Jackson, Frederic, Jackson, Susan, Jaumdally, Shameem, Jeffers, Helen, Jesudason, Natasha, Jones, Carina, Jones, Christopher, Jones, Kathryn, Jones, Elizabeth, Jorge, Marianna Rocha, Joshi, Amar, Júnior, Eduardo A.M.S., Kailath, Reshma, Kana, Faeeza, Kar, Arnab, Karampatsas, Konstantinos, Kasanyinga, Mwila, Kay, Linda, Keen, Jade, Kellett Wright, Johanna, Kelly, Elizabeth J., Kelly, Debbie, Kelly, Dearbhla M., Kelly, Sarah, Kerr, David, Khan, Liaquat, Khozoee, Baktash, Khurana, Ankush, Kidd, Sarah, Killen, Annabel, Kinch, Jasmin, Kinch, Patrick, King, Lloyd D.W., King, Thomas B., Kingham, Lucy, Klenerman, Paul, Kluczna, Diana M., Knapper, Francesca, Knight, Julian C., Knott, Daniel, Koleva, Stanislava, Lages, Pedro M., Lang, Matilda, Lang, Gail, Larkworthy, Colin W., Larwood, Jessica P.J., Law, Rebecca, Lawrie, Alison M., Lazarus, Erica M., Leach, Amanda, Lees, Emily A., Lelliott, Alice, Lemm, Nana-Marie, Lessa, Alvaro Edson Ramos, Leung, Stephanie, Li, Yuanyuan, Lias, Amelia M., Liatsikos, Konstantinos, Linder, Aline, Lipworth, Samuel, Liu, Shuchang, Liu, Xinxue, Lloyd, Adam, Lloyd, Stephanie, Loew, Lisa, Lopez Ramon, Raquel, Lora, Leandro Bonecker, Luz, Kleber Giovanni, MacDonald, Jonathan C., MacGregor, Gordon, Madhavan, Meera, Mainwaring, David O., Makambwa, Edson, Makinson, Rebecca, Malahleha, Mookho, Malamatsho, Ross, Mallett, Garry, Manning, Nicola, Mansatta, Kushal, Maoko, Takalani, Marinou, Spyridoula, Marlow, Emma, Marques, Gabriela N., Marriott, Paula, Marshall, Richard P., Marshall, Julia L., Masenya, Masebole, Masilela, Mduduzi, Masters, Shauna K., Mathew, Moncy, Matlebjane, Hosea, Matshidiso, Kedidimetse, Mazur, Olga, Mazzella, Andrea, McCaughan, Hugh, McEwan, Joanne, McGlashan, Joanna, McInroy, Lorna, McRobert, Nicky, McSwiggan, Steve, Megson, Clare, Mehdipour, Savviz, Meijs, Wilma, Mendonça, Renata N.Õ., Mentzer, Alexander J., Mesquita, Ana Carolina F., Miralhes, Patricia, Mirtorabi, Neginsadat, Mitton, Celia, Mnyakeni, Sibusiso, Moghaddas, Fiona, Molapo, Kgaogelo, Moloi, Mapule, Moore, Maria, Moran, Marni, Morey, Ella, Morgans, Róisín, Morris, Susan J., Morris, Sheila, Morrison, Hazel, Morselli, Franca, Morshead, Gertraud, Morter, Richard, Mottay, Lynelle, Moultrie, Andrew, Moyo, Nathifa, Mpelembue, Mushiya, Msomi, Sibekezelo, Mugodi, Yvonne, Mukhopadhyay, Ekta, Muller, Jilly, Munro, Alasdair, Murphy, Sarah, Mweu, Philomena, Myerscough, Christopher, Naik, Gurudutt, Naker, Kush, Nastouli, Eleni, Ndlovu, Bongani, Nikolaou, Elissavet, Njenga, Cecilia, Noal, Helena C., Noé, Andrés, Novaes, Gabrielle, Nugent, Fay L., Nunes, Géssika Lanzillo A., O'Brien, Katie, O'Connor, Daniel, Oelofse, Suzette, Oguti, Blanche, Olchawski, Victoria, Oldfield, Neil J., Oliveira, Marianne G., Oliveira, Catarina, Oliveira, Isabelle Silva Queiroz, Oommen-Jose, Aylin, Oosthuizen, Angela, O'Reilly, Paula, O'Reilly, Peter J., Osborne, Piper, Owen, David R.J., Owen, Lydia, Owens, Daniel, Owino, Nelly, Pacurar, Mihaela, Paiva, Brenda V.B., Palhares, Edna M.F., Palmer, Susan, Parracho, Helena M. R.T., Parsons, Karen, Patel, Dipak, Patel, Bhumika, Patel, Faeezah, Patrick-Smith, Maia, Payne, Ruth O., Peng, Yanchun, Penn, Elizabeth J., Pennington, Anna, Peralta Alvarez, Marco Polo, Pereira Stuchi, Bruno Pereira, Perez, Ana Luiza, Perinpanathan, Tanaraj, Perring, James, Perumal, Rubeshan, Petkar, Sahir Yusuf, Philip, Tricia, Phillips, Jennifer, Phohu, Mary Kgomotso, Pickup, Lorinda, Pieterse, Sonja, Pinheiro, Jessica Morgana, Piper, Jo, Pipini, Dimitra, Plank, Mary, Plant, Sinéad, Pollard, Samuel, Pooley, Jennifer, Pooran, Anil, Poulton, Ian, Powers, Claire, Presa, Fernando B., Price, David A., Price, Vivien, Primeira, Marcelo R., Proud, Pamela C., Provstgaard-Morys, Samuel, Pueschel, Sophie, Pulido, David, Quaid, Sheena, Rabara, Ria, Radia, Kajal, Rajapaska, Durga, Rajeswaran, Thurkka, Ramos, Leonardo, Ramos, Alberto San Francisco, Ramos Lopez, Fernando, Rampling, Tommy, Rand, Jade, Ratcliffe, Helen, Rawlinson, Tom, Rea, David, Rees, Byron, Resuello-Dauti, Mila, Reyes Pabon, Emilia, Rhead, Sarah, Riaz, Tawassal, Ricamara, Marivic, Richards, Alexander, Richter, Alex, Ritchie, Neil, Ritchie, Adam J., Robbins, Alexander J., Roberts, Hannah, Robinson, Ryan E., Roche, Sophie, Rollier, Christine, Rose, Louisa, Ross Russell, Amy L., Rossouw, Lindie, Royal, Simon, Rudiansyah, Indra, Ryalls, Kim, Sabine, Charlotte, Saich, Stephen, Sale, Jessica C., Salman, Ahmed M., Salvador, Natalia, Salvador, Stephannie, Sampaio, Milla Dias, Samson, Annette D., Sanchez-Gonzalez, Amada, Sanders, Helen, Sanders, Katherine, Santos, Erika, Santos Guerra, Mayara F.S., Satti, Iman, Saunders, Jack E., Saunders, Caroline, Sayed, Aakifah Bibi Arif, Schim van der Loeff, Ina, Schmid, Annina B., Schofield, Ella, Screaton, Gavin R., Seddiqi, Samiullah, Segireddy, Rameswara R., Senger, Roberta, Serrano, Sonia, Shaik, Imam, Sharpe, Hannah R., Sharrocks, Katherine, Shaw, Robert, Shea, Adam, Sheehan, Emma, Shepherd, Amy, Shiham, Farah, Silk, Sarah E., Silva-Reyes, Laura, Silveira, Lidiana B. T.D., Silveira, Mariana B.V., Singh, Nisha, Sinha, Jaisi, Skelly, Donal T., Smith, Daniel C., Smith, Nick, Smith, Holly E., Smith, David J., Smith, Catherine C., Soares, Airanuédida S., Solórzano, Carla, Sorio, Guilherme L., Sorley, Kim, Sosa-Rodriguez, Tiffany, Souza, Cinthia M.C.D.L., Souza, Bruno S.D.F., Souza, Alessandra R., Souza Lopez, Thamyres, Sowole, Luciana, Spencer, Alexandra J., Spoors, Louise, Stafford, Lizzie, Stamford, Imogen, Stein, Ricardo, Stockdale, Lisa, Stockwell, Lisa V., Strickland, Louise H., Stuart, Arabella, Sturdy, Ann, Sutton, Natalina, Szigeti, Anna, Tahiri-Alaoui, Abdessamad, Tanner, Rachel, Taoushanis, Carol, Tarr, Alexander W., Tarrant, Richard, Taylor, Keja, Taylor, Ursula, Taylor, Iona Jennifer, Taylor, Justin, te Water Naude, Rebecca, Templeton, Kate, Themistocleous, Yrene, Themistocleous, Andreas, Thomas, Merin, Thomas, Kelly, Thomas, Tonia M., Thombrayil, Asha, Thompson, Julia, Thompson, Fawziyah, Thompson, Ameeka, Thompson, Amber, Thompson, Kevin, Thornton-Jones, Viv, Thotusi, Larissa H.S., Tighe, Patrick J., Tinoco, Lygia Accioly, Tiongson, Gerlynn Ferreras, Tladinyane, Bonolo, Tomasicchio, Michele, Tomic, Adriana, Tonks, Susan, Towner, James, Tran, Nguyen, Tree, Julia A., Trillana, Gerry, Trinham, Charlotte, Trivett, Rose, Truby, Adam, Tsheko, Betty Lebogang, Tubb, Philippa, Turabi, Aadil, Turner, Richard, Turner, Cheryl, Turner, Nicola, Tyagi, Bhavya, Ulaszewska, Marta, Underwood, Benjamin R., van Eck, Samual, Varughese, Rachel, Verbart, Dennis, Verheul, Marije K., Vichos, Iason, Vieira, Taiane A., Walker, Gemma, Walker, Laura, Wand, Matthew E., Wardell, Theresa, Warimwe, George M., Warren, Sarah C., Watkins, Bridget, Watson, Marion E.E., Watson, Ekaterina, Webb, Stewart, Webster, Angela, Welch, Jessica, Wellbelove, Zoe, Wells, Jeanette H., West, Alison J., White, Beth, White, Caroline, White, Rachel, Williams, Paul, Williams, Rachel L., Willingham, Silvia, Winslow, Rebecca, Woods, Danielle, Woodyer, Mark, Worth, Andrew T., Wright, Danny, Wroblewska, Marzena, Yao, Andy, Yim, Yee Ting Nicole, Zambrano, Marina Bauer, Zimmer, Rafael Leal, Zizi, Dalila, Zuidewind, Peter, Voysey, Merryn, Costa Clemens, Sue Ann, Madhi, Shabir A, Weckx, Lily Y, Folegatti, Pedro M, Aley, Parvinder K, Angus, Brian, Baillie, Vicky L, Barnabas, Shaun L, Bhorat, Qasim E, Bibi, Sagida, Briner, Carmen, Cicconi, Paola, Clutterbuck, Elizabeth A, Collins, Andrea M, Cutland, Clare L, Darton, Thomas C, Dheda, Keertan, Dold, Christina, Duncan, Christopher J A, Emary, Katherine R W, Ewer, Katie J, Flaxman, Amy, Fairlie, Lee, Faust, Saul N, Feng, Shuo, Ferreira, Daniela M, Finn, Adam, Galiza, Eva, Goodman, Anna L, Green, Catherine M, Green, Christopher A, Greenland, Melanie, Hill, Catherine, Hill, Helen C, Hirsch, Ian, Izu, Alane, Jenkin, Daniel, Joe, Carina C D, Kerridge, Simon, Koen, Anthonet, Kwatra, Gaurav, Lazarus, Rajeka, Libri, Vincenzo, Lillie, Patrick J, Marchevsky, Natalie G, Marshall, Richard P, Mendes, Ana V A, Milan, Eveline P, Minassian, Angela M, McGregor, Alastair, Mujadidi, Yama F, Nana, Anusha, Padayachee, Sherman D, Phillips, Daniel J, Pittella, Ana, Plested, Emma, Pollock, Katrina M, Ramasamy, Maheshi N, Ritchie, Adam J, Robinson, Hannah, Schwarzbold, Alexandre V, Smith, Andrew, Song, Rinn, Snape, Matthew D, Sprinz, Eduardo, Sutherland, Rebecca K, Thomson, Emma C, Török, M Estée, Toshner, Mark, Turner, David P J, Vekemans, Johan, Villafana, Tonya L, White, Thomas, Williams, Christopher J, Douglas, Alexander D, Hill, Adrian V S, Lambe, Teresa, Gilbert, Sarah C, and Pollard, Andrew J
- Published
- 2021
- Full Text
- View/download PDF
10. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
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Aban, Marites, Abayomi, Fatola, Abeyskera, Kushala, Aboagye, Jeremy, Adam, Matthew, Adams, Kirsty, Adamson, James, Adelaja, Yemi A., Adewetan, Gbadebo, Adlou, Syed, Ahmed, Khatija, Akhalwaya, Yasmeen, Akhalwaya, Saajida, Alcock, Andrew, Ali, Aabidah, Allen, Elizabeth R., Allen, Lauren, Almeida, Thamires C. D. S. C, Alves, Mariana P.S., Amorim, Fabio, Andritsou, Foteini, Anslow, Rachel, Appleby, Matthew, Arbe-Barnes, Edward H., Ariaans, Mark P., Arns, Beatriz, Arruda, Laiana, Azi, Paula, Azi, Lorena, Babbage, Gavin, Bailey, Catherine, Baker, Kenneth F., Baker, Megan, Baker, Natalie, Baker, Philip, Baldwin, Lisa, Baleanu, Ioana, Bandeira, Danieli, Bara, Anna, Barbosa, Marcella A.S., Barker, Debbie, Barlow, Gavin D., Barnes, Eleanor, Barr, Andrew S., Barrett, Jordan R., Barrett, Jessica, Bates, Louise, Batten, Alexander, Beadon, Kirsten, Beales, Emily, Beckley, Rebecca, Belij-Rammerstorfer, Sandra, Bell, Jonathan, Bellamy, Duncan, Bellei, Nancy, Belton, Sue, Berg, Adam, Bermejo, Laura, Berrie, Eleanor, Berry, Lisa, Berzenyi, Daniella, Beveridge, Amy, Bewley, Kevin R., Bexhell, Helen, Bhikha, Sutika, Bhorat, Asad E., Bhorat, Zaheda E., Bijker, Else, Birch, Geeta, Birch, Sarah, Bird, Adam, Bird, Olivia, Bisnauthsing, Karen, Bittaye, Mustapha, Blackstone, Katherine, Blackwell, Luke, Bletchly, Heather, Blundell, Caitlin L., Blundell, Susannah R., Bodalia, Pritesh, Boettger, Bruno C., Bolam, Emma, Boland, Elena, Bormans, Daan, Borthwick, Nicola, Bowring, Francesca, Boyd, Amy, Bradley, Penny, Brenner, Tanja, Brown, Phillip, Brown, Claire, Brown-O'Sullivan, Charlie, Bruce, Scott, Brunt, Emily, Buchan, Ruaridh, Budd, William, Bulbulia, Yusuf A., Bull, Melanie, Burbage, Jamie, Burhan, Hassan, Burn, Aileen, Buttigieg, Karen R., Byard, Nicholas, Cabera Puig, Ingrid, Calderon, Gloria, Calvert, Anna, Camara, Susana, Cao, Michelangelo, Cappuccini, Federica, Cardoso, João R., Carr, Melanie, Carroll, Miles W., Carson-Stevens, Andrew, Carvalho, Yasmin de M., Carvalho, José A.M., Casey, Helen R., Cashen, Paul, Castro, Thais, Castro, Lucia Carratala, Cathie, Katrina, Cavey, Ana, Cerbino-Neto, José, Chadwick, Jim, Chapman, David, Charlton, Sue, Chelysheva, Irina, Chester, Oliver, Chita, Sunder, Cho, Jee-Sun, Cifuentes, Liliana, Clark, Elizabeth, Clark, Matthew, Clarke, Andrea, Clutterbuck, Elizabeth A., Collins, Sarah L.K., Conlon, Christopher P., Connarty, Sean, Coombes, Naomi, Cooper, Cushla, Cooper, Rachel, Cornelissen, Lynne, Corrah, Tumena, Cosgrove, Catherine, Cox, Tony, Crocker, Wendy E.M., Crosbie, Sarah, Cullen, Lorraine, Cullen, Dan, Cunha, Debora R.M.F., Cunningham, Christina, Cuthbertson, Fiona C., Da Guarda, Suzete N. Farias, da Silva, Larissa P., Damratoski, Brad E., Danos, Zsofia, Dantas, Maria T.D.C., Darroch, Paula, Datoo, Mehreen S., Datta, Chandrabali, Davids, Malika, Davies, Sarah L., Davies, Hannah, Davis, Elizabeth, Davis, Judith, Davis, John, De Nobrega, Maristela M.D., De Oliveira Kalid, Lis Moreno, Dearlove, David, Demissie, Tesfaye, Desai, Amisha, Di Marco, Stefania, Di Maso, Claudio, Dinelli, Maria I.S., Dinesh, Tanya, Docksey, Claire, Dold, Christina, Dong, Tao, Donnellan, Francesca R., Dos Santos, Tannyth, dos Santos, Thainá G., Dos Santos, Erika Pachecho, Douglas, Naomi, Downing, Charlotte, Drake, Jonathan, Drake-Brockman, Rachael, Driver, Kimberley, Drury, Ruth, Dunachie, Susanna J., Durham, Benjamin S., Dutra, Lidiana, Easom, Nicholas J.W., van Eck, Samual, Edwards, Mandy, Edwards, Nick J., El Muhanna, Omar M., Elias, Sean C., Elmore, Mike, English, Marcus, Esmail, Alisgair, Essack, Yakub Moosa, Farmer, Eoghan, Farooq, Mutjaba, Farrar, Madi, Farrugia, Leonard, Faulkner, Beverley, Fedosyuk, Sofiya, Felle, Sally, Feng, Shuo, Ferreira Da Silva, Carla, Field, Samantha, Fisher, Richard, Flaxman, Amy, Fletcher, James, Fofie, Hazel, Fok, Henry, Ford, Karen J., Fowler, Jamie, Fraiman, Pedro H.A., Francis, Emma, Franco, Marilia M., Frater, John, Freire, Marilúcia S.M., Fry, Samantha H., Fudge, Sabrina, Furze, Julie, Fuskova, Michelle, Galian-Rubio, Pablo, Galiza, Eva, Garlant, Harriet, Gavrila, Madita, Geddes, Ailsa, Gibbons, Karyna A., Gilbride, Ciaran, Gill, Hardeep, Glynn, Sharon, Godwin, Kerry, Gokani, Karishma, Goldoni, Ursula Carvalho, Goncalves, Maria, Gonzalez, Isabela G.S., Goodwin, Jayne, Goondiwala, Amina, Gordon-Quayle, Katherine, Gorini, Giacomo, Grab, Janet, Gracie, Lara, Greenland, Melanie, Greenwood, Nicola, Greffrath, Johann, Groenewald, Marisa M., Grossi, Leonardo, Gupta, Gaurav, Hackett, Mark, Hallis, Bassam, Hamaluba, Mainga, Hamilton, Elizabeth, Hamlyn, Joseph, Hammersley, Daniel, Hanrath, Aidan T., Hanumunthadu, Brama, Harris, Stephanie A., Harris, Clair, Harris, Tara, Harrison, Thomas D., Harrison, Daisy, Hart, Thomas C., Hartnell, Birgit, Hassan, Shadin, Haughney, John, Hawkins, Sophia, Hay, Jodie, Head, Ian, Henry, John, Hermosin Herrera, Macarena, Hettle, David B., Hill, Jennifer, Hodges, Gina, Horne, Elizea, Hou, Mimi M., Houlihan, Catherine, Howe, Elizabeth, Howell, Nicola, Humphreys, Jonathan, Humphries, Holly E., Hurley, Katrina, Huson, Claire, Hyder-Wright, Angela, Hyams, Catherine, Ikram, Sabina, Ishwarbhai, Alka, Ivan, Monica, Iveson, Poppy, Iyer, Vidyashankara, Jackson, Frederic, De Jager, Jeanne, Jaumdally, Shameem, Jeffers, Helen, Jesudason, Natasha, Jones, Bryony, Jones, Kathryn, Jones, Elizabeth, Jones, Christopher, Jorge, Marianna Rocha, Jose, Aylin, Joshi, Amar, Júnior, Eduardo A.M.S., Kadziola, Joanne, Kailath, Reshma, Kana, Faeeza, Karampatsas, Konstantinos, Kasanyinga, Mwila, Keen, Jade, Kelly, Elizabeth J., Kelly, Dearbhla M., Kelly, Debbie, Kelly, Sarah, Kerr, David, Kfouri, Renato de Ávila, Khan, Liaquat, Khozoee, Baktash, Kidd, Sarah, Killen, Annabel, Kinch, Jasmin, Kinch, Patrick, King, Lloyd D.W., King, Thomas B., Kingham, Lucy, Klenerman, Paul, Knapper, Francesca, Knight, Julian C., Knott, Daniel, Koleva, Stanislava, Lang, Matilda, Lang, Gail, Larkworthy, Colin W., Larwood, Jessica P.J., Law, Rebecca, Lazarus, Erica M., Leach, Amanda, Lees, Emily A., Lemm, Nana-Marie, Lessa, Alvaro, Leung, Stephanie, Li, Yuanyuan, Lias, Amelia M., Liatsikos, Kostas, Linder, Aline, Lipworth, Samuel, Liu, Shuchang, Liu, Xinxue, Lloyd, Adam, Lloyd, Stephanie, Loew, Lisa, Lopez Ramon, Raquel, Lora, Leandro, Lowthorpe, Vicki, Luz, Kleber, MacDonald, Jonathan C., MacGregor, Gordon, Madhavan, Meera, Mainwaring, David O., Makambwa, Edson, Makinson, Rebecca, Malahleha, Mookho, Malamatsho, Ross, Mallett, Garry, Mansatta, Kushal, Maoko, Takalani, Mapetla, Katlego, Marchevsky, Natalie G., Marinou, Spyridoula, Marlow, Emma, Marques, Gabriela N., Marriott, Paula, Marshall, Richard P., Marshall, Julia L., Martins, Flávia J., Masenya, Masebole, Masilela, Mduduzi, Masters, Shauna K., Mathew, Moncy, Matlebjane, Hosea, Matshidiso, Kedidimetse, Mazur, Olga, Mazzella, Andrea, McCaughan, Hugh, McEwan, Joanne, McGlashan, Joanna, McInroy, Lorna, McIntyre, Zoe, McLenaghan, Daniela, McRobert, Nicky, McSwiggan, Steve, Megson, Clare, Mehdipour, Savviz, Meijs, Wilma, Mendonça, Renata N.Á., Mentzer, Alexander J., Mirtorabi, Neginsadat, Mitton, Celia, Mnyakeni, Sibusiso, Moghaddas, Fiona, Molapo, Kgaogelo, Moloi, Mapule, Moore, Maria, Moraes-Pinto, M. Isabel, Moran, Marni, Morey, Ella, Morgans, Róisín, Morris, Susan, Morris, Sheila, Morris, Helen C., Morselli, Franca, Morshead, Gertraud, Morter, Richard, Mottal, Lynelle, Moultrie, Andrew, Moya, Nathifa, Mpelembue, Mushiya, Msomi, Sibekezelo, Mugodi, Yvonne, Mukhopadhyay, Ekta, Muller, Jilly, Munro, Alasdair, Munro, Claire, Murphy, Sarah, Mweu, Philomena, Myasaki, Celia Hatsuko, Naik, Gurudutt, Naker, Kush, Nastouli, Eleni, Nazir, Abida, Ndlovu, Bongani, Neffa, Fabio, Njenga, Cecilia, Noal, Helena, Noé, Andrés, Novaes, Gabrielle, Nugent, Fay L., Nunes, Géssika, O'Brien, Katie, O'Connor, Daniel, Odam, Miranda, Oelofse, Suzette, Oguti, Blanche, Olchawski, Victoria, Oldfield, Neil J., Oliveira, Marianne G., Oliveira, Catarina, Oosthuizen, Angela, O'Reilly, Paula, Osborne, Piper, Owen, David R.J., Owen, Lydia, Owens, Daniel, Owino, Nelly, Pacurar, Mihaela, Paiva, Brenda V.B., Palhares, Edna M.F., Palmer, Susan, Parkinson, Sivapriyai, Parracho, Helena M.R.T., Parsons, Karen, Patel, Dipak, Patel, Bhumika, Patel, Faeezah, Patel, Kelly, Patrick-Smith, Maia, Payne, Ruth O., Peng, Yanchun, Penn, Elizabeth J., Pennington, Anna, Peralta Alvarez, Marco Polo, Perring, James, Perry, Nicola, Perumal, Rubeshan, Petkar, Sahir, Philip, Tricia, Phillips, Daniel J., Phillips, Jennifer, Phohu, Mary Kgomotso, Pickup, Lorinda, Pieterse, Sonja, Piper, Jo, Pipini, Dimitra, Plank, Mary, Du Plessis, Joan, Pollard, Samuel, Pooley, Jennifer, Pooran, Anil, Poulton, Ian, Powers, Claire, Presa, Fernando B., Price, David A., Price, Vivien, Primeira, Marcelo, Proud, Pamela C., Provstgaard-Morys, Samuel, Pueschel, Sophie, Pulido, David, Quaid, Sheena, Rabara, Ria, Radford, Alexandra, Radia, Kajal, Rajapaska, Durga, Rajeswaran, Thurkka, Ramos, Alberto San Francisco, Ramos Lopez, Fernando, Rampling, Tommy, Rand, Jade, Ratcliffe, Helen, Rawlinson, Tom, Rea, David, Rees, Byron, Reiné, Jesús, Resuello-Dauti, Mila, Reyes Pabon, Emilia, Ribiero, Carla M., Ricamara, Marivic, Richter, Alex, Ritchie, Neil, Ritchie, Adam J., Robbins, Alexander J., Roberts, Hannah, Robinson, Ryan E., Robinson, Hannah, Rocchetti, Talita T., Rocha, Beatriz Pinho, Roche, Sophie, Rollier, Christine, Rose, Louisa, Ross Russell, Amy L., Rossouw, Lindie, Royal, Simon, Rudiansyah, Indra, Ruiz, Sarah, Saich, Stephen, Sala, Claudia, Sale, Jessica, Salman, Ahmed M., Salvador, Natalia, Salvador, Stephannie, Sampaio, Milla, Samson, Annette D., Sanchez-Gonzalez, Amada, Sanders, Helen, Sanders, Katherine, Santos, Erika, Santos Guerra, Mayara F.S., Satti, Iman, Saunders, Jack E., Saunders, Caroline, Sayed, Aakifah, Schim van der Loeff, Ina, Schmid, Annina B., Schofield, Ella, Screaton, Gavin, Seddiqi, Samiullah, Segireddy, Rameswara R., Senger, Roberta, Serrano, Sonia, Shah, Rajiv, Shaik, Imam, Sharpe, Hannah E., Sharrocks, Katherine, Shaw, Robert, Shea, Adam, Shepherd, Amy, Shepherd, James G., Shiham, Farah, Sidhom, Emad, Silk, Sarah E., da Silva Moraes, Antonio Carlos, Silva-Junior, Gilberto, Silva-Reyes, Laura, Silveira, Anderson D., Silveira, Mariana B.V., Sinha, Jaisi, Skelly, Donal T., Smith, Daniel C., Smith, Nick, Smith, Holly E., Smith, David J., Smith, Catherine C., Soares, Airanuédida, Soares, Tiago, Solórzano, Carla, Sorio, Guilherme L., Sorley, Kim, Sosa-Rodriguez, Tiffany, Souza, Cinthia M.C.D.L., Souza, Bruno S.D.F., Souza, Alessandra R., Spencer, Alexandra J., Spina, Fernanda, Spoors, Louise, Stafford, Lizzie, Stamford, Imogen, Starinskij, Igor, Stein, Ricardo, Steven, Jill, Stockdale, Lisa, Stockwell, Lisa V., Strickland, Louise H., Stuart, Arabella C., Sturdy, Ann, Sutton, Natalina, Szigeti, Anna, Tahiri-Alaoui, Abdessamad, Tanner, Rachel, Taoushanis, Carol, Tarr, Alexander W., Taylor, Keja, Taylor, Ursula, Taylor, Iona Jennifer, Taylor, Justin, te Water Naude, Rebecca, Themistocleous, Yrene, Themistocleous, Andreas, Thomas, Merin, Thomas, Kelly, Thomas, Tonia M., Thombrayil, Asha, Thompson, Fawziyah, Thompson, Amber, Thompson, Kevin, Thompson, Ameeka, Thomson, Julia, Thornton-Jones, Viv, Tighe, Patrick J., Tinoco, Lygia Accioly, Tiongson, Gerlynn, Tladinyane, Bonolo, Tomasicchio, Michele, Tomic, Adriana, Tonks, Susan, Towner, James, Tran, Nguyen, Tree, Julia, Trillana, Gerry, Trinham, Charlotte, Trivett, Rose, Truby, Adam, Tsheko, Betty Lebogang, Turabi, Aadil, Turner, Richard, Turner, Cheryl, Ulaszewska, Marta, Underwood, Benjamin R., Varughese, Rachel, Verbart, Dennis, Verheul, Marije, Vichos, Iason, Vieira, Taiane, Waddington, Claire S., Walker, Laura, Wallis, Erica, Wand, Matthew, Warbick, Deborah, Wardell, Theresa, Warimwe, George, Warren, Sarah C., Watkins, Bridget, Watson, Ekaterina, Webb, Stewart, Webb-Bridges, Alice, Webster, Angela, Welch, Jessica, Wells, Jeanette, West, Alison, White, Caroline, White, Rachel, Williams, Paul, Williams, Rachel L., Winslow, Rebecca, Woodyer, Mark, Worth, Andrew T., Wright, Danny, Wroblewska, Marzena, Yao, Andy, Zimmer, Rafael, Zizi, Dalila, Zuidewind, Peter, Voysey, Merryn, Clemens, Sue Ann Costa, Madhi, Shabir A, Weckx, Lily Y, Folegatti, Pedro M, Aley, Parvinder K, Angus, Brian, Baillie, Vicky L, Barnabas, Shaun L, Bhorat, Qasim E, Bibi, Sagida, Briner, Carmen, Cicconi, Paola, Collins, Andrea M, Colin-Jones, Rachel, Cutland, Clare L, Darton, Thomas C, Dheda, Keertan, Duncan, Christopher J A, Emary, Katherine R W, Ewer, Katie J, Fairlie, Lee, Faust, Saul N, Ferreira, Daniela M, Finn, Adam, Goodman, Anna L, Green, Catherine M, Green, Christopher A, Heath, Paul T, Hill, Catherine, Hill, Helen, Hirsch, Ian, Hodgson, Susanne H C, Izu, Alane, Jackson, Susan, Jenkin, Daniel, Joe, Carina C D, Kerridge, Simon, Koen, Anthonet, Kwatra, Gaurav, Lazarus, Rajeka, Lawrie, Alison M, Lelliott, Alice, Libri, Vincenzo, Lillie, Patrick J, Mallory, Raburn, Mendes, Ana V A, Milan, Eveline P, Minassian, Angela M, McGregor, Alastair, Morrison, Hazel, Mujadidi, Yama F, Nana, Anusha, O’Reilly, Peter J, Padayachee, Sherman D, Pittella, Ana, Plested, Emma, Pollock, Katrina M, Ramasamy, Maheshi N, Rhead, Sarah, Schwarzbold, Alexandre V, Singh, Nisha, Smith, Andrew, Song, Rinn, Snape, Matthew D, Sprinz, Eduardo, Sutherland, Rebecca K, Tarrant, Richard, Thomson, Emma C, Török, M Estée, Toshner, Mark, Turner, David P J, Vekemans, Johan, Villafana, Tonya L, Watson, Marion E E, Williams, Christopher J, Douglas, Alexander D, Hill, Adrian V S, Lambe, Teresa, Gilbert, Sarah C, and Pollard, Andrew J
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- 2021
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11. Early Proteomic and Innate Immunity Profiles: A Footprint of Increased Mortality Risk In Infants Living with Hiv From Three African Countries
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Morrocchi, Elena, primary, Pascucci, Giuseppe Rubens, additional, Cotugno, Nicola, additional, Pighi, Chiara, additional, Domínguez-Rodríguez, Sara, additional, Petrara, Maria Raffaella, additional, Tagarro, Alfredo, additional, Kuhn, Louise, additional, Cotton, Mark F., additional, Otwombe, Kennedy, additional, Lain, Maria Grazia, additional, Vaz, Paula, additional, Barnabas, Shaun L., additional, Spyer, Moira J., additional, Lopez Varela, Elisa, additional, Fernandez-Luis, Sheila, additional, Nhampossa, Tacilta, additional, Maiga, Almoustapha Issiaka, additional, Dolo, Oumar, additional, De Rossi, Anita, additional, Rojo, Pablo, additional, Giaquinto, Carlo, additional, Lichterfeld, Matthias, additional, Violari, Avy, additional, Smit, Theresa, additional, Behuhuma, Osee, additional, Klein, Nigel, additional, De Armas, Lesley, additional, Pahwa, Savita, additional, Rossi, Paolo, additional, Palma, Paolo, additional, and Consortium, EPIICAL, additional
- Published
- 2024
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12. Testing the regulatory framework in South Africa – a single-blind randomized pilot trial of commercial probiotic supplementation to standard therapy in women with bacterial vaginosis
- Author
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Happel, Anna-Ursula, Singh, Ravesh, Mitchev, Nireshni, Mlisana, Koleka, Jaspan, Heather B., Barnabas, Shaun L., and Passmore, Jo-Ann S.
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- 2020
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13. Inflammatory and antimicrobial properties differ between vaginal Lactobacillus isolates from South African women with non-optimal versus optimal microbiota
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Manhanzva, Monalisa T., Abrahams, Andrea G., Gamieldien, Hoyam, Froissart, Remy, Jaspan, Heather, Jaumdally, Shameem Z., Barnabas, Shaun L., Dabee, Smritee, Bekker, Linda G., Gray, Glenda, Passmore, Jo-Ann S., and Masson, Lindi
- Published
- 2020
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14. Potential for Maternally Administered Vaccine for Infant Group B Streptococcus
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Madhi, Shabir A., primary, Anderson, Annaliesa S., additional, Absalon, Judith, additional, Radley, David, additional, Simon, Raphael, additional, Jongihlati, Babalwa, additional, Strehlau, Renate, additional, van Niekerk, Anika M., additional, Izu, Alane, additional, Naidoo, Niree, additional, Kwatra, Gaurav, additional, Ramsamy, Yogandree, additional, Said, Mohamed, additional, Jones, Stephanie, additional, Jose, Lisa, additional, Fairlie, Lee, additional, Barnabas, Shaun L., additional, Newton, Ryan, additional, Munson, Samantha, additional, Jefferies, Zahra, additional, Pavliakova, Danka, additional, Silmon de Monerri, Natalie C., additional, Gomme, Emily, additional, Perez, John L., additional, Scott, Daniel A., additional, Gruber, William C., additional, and Jansen, Kathrin U., additional
- Published
- 2023
- Full Text
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15. Female genital tract inflammation, HIV co-infection and persistent mucosal Human Papillomavirus (HPV) infections
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Kriek, Jean-Mari, Jaumdally, Shameem Z., Masson, Lindi, Little, Francesca, Mbulawa, Zizipho, Gumbi, Pamela P., Barnabas, Shaun L., Moodley, Jennifer, Denny, Lynette, Coetzee, David, Williamson, Anna-Lise, and Passmore, Jo-Ann S.
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- 2016
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16. Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants
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Kampmann, Beate, primary, Madhi, Shabir A., additional, Munjal, Iona, additional, Simões, Eric A.F., additional, Pahud, Barbara A., additional, Llapur, Conrado, additional, Baker, Jeffrey, additional, Pérez Marc, Gonzalo, additional, Radley, David, additional, Shittu, Emma, additional, Glanternik, Julia, additional, Snaggs, Hasra, additional, Baber, James, additional, Zachariah, Philip, additional, Barnabas, Shaun L., additional, Fausett, Merlin, additional, Adam, Tyler, additional, Perreras, Nicole, additional, Van Houten, Marlies A., additional, Kantele, Anu, additional, Huang, Li-Min, additional, Bont, Louis J., additional, Otsuki, Takeo, additional, Vargas, Sergio L., additional, Gullam, Joanna, additional, Tapiero, Bruce, additional, Stein, Renato T., additional, Polack, Fernando P., additional, Zar, Heather J., additional, Staerke, Nina B., additional, Duron Padilla, María, additional, Richmond, Peter C., additional, Koury, Kenneth, additional, Schneider, Katherine, additional, Kalinina, Elena V., additional, Cooper, David, additional, Jansen, Kathrin U., additional, Anderson, Annaliesa S., additional, Swanson, Kena A., additional, Gruber, William C., additional, and Gurtman, Alejandra, additional
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- 2023
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17. Associations of HIV and iron status with gut microbiota composition, gut inflammation and gut integrity in South African school‐age children: a two‐way factorial case–control study
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Goosen, Charlene, primary, Proost, Sebastian, additional, Baumgartner, Jeannine, additional, Mallick, Kashish, additional, Tito, Raul Y., additional, Barnabas, Shaun L., additional, Cotton, Mark F., additional, Zimmermann, Michael B., additional, Raes, Jeroen, additional, and Blaauw, Renée, additional
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- 2023
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18. Efficacy of Primary Series AZD1222 (ChAdOx1 nCoV-19) Vaccination Against SARS-CoV-2 Variants of Concern: Final Analysis of a Randomized, Placebo-controlled, Phase 1b/2 Study in South African Adults (COV005)
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Koen, Anthonet L., primary, Izu, Alane, additional, Baillie, Vicky, additional, Kwatra, Gaurav, additional, Cutland, Clare L., additional, Fairlie, Lee, additional, Padayachee, Sherman D., additional, Dheda, Keertan, additional, Barnabas, Shaun L., additional, Ebrahim Bhorat, Qasim, additional, Briner, Carmen, additional, Ahmed, Khatija, additional, Bhikha, Sutika, additional, Bhiman, Jinal N., additional, du Plessis, Jeanine, additional, Esmail, Aliasgar, additional, Horne, Elizea, additional, Hwa, Shi-Hsia, additional, Oommen-Jose, Aylin, additional, Lambe, Teresa, additional, Laubscher, Matt, additional, Malahleha, Mookho, additional, Benade, Gabriella, additional, McKenzie, Shakeel, additional, Oelofse, Suzette, additional, Patel, Faeezah, additional, Pillay, Sureshnee, additional, Rhead, Sarah, additional, Rodel, Hylton, additional, Taoushanis, Carol, additional, Tegally, Houriiyah, additional, Thombrayil, Asha, additional, Villafana, Tonya L., additional, Gilbert, Sarah, additional, Pollard, Andrew J., additional, and Madhi, Shabir A., additional
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- 2023
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19. High Mortality Following Early Initiation of Antiretroviral Therapy in Infants Living with HIV from Three African Countries
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Tagarro, Alfredo, primary, Domínguez-Rodríguez, Sara, additional, Cotton, Mark F., additional, Otwombe, Kennedy, additional, Klein, Nigel, additional, Lain, Maria Grazia, additional, Nhampossa, Tacilta, additional, Maiga, Almoustapha Issiaka, additional, Barnabas, Shaun L., additional, Vaz, Paula, additional, Violari, Avy, additional, Fernandez-Luis, Sheila, additional, Behuhuma, Osee, additional, Estevao, Ligia, additional, Sillah, Mariam, additional, Lopez Varela, Elisa, additional, Naniche, Denise, additional, Janse-Van-Rensburg, Anita, additional, Liberty, Afaaf, additional, Ramsagar, Nastassja, additional, Smit, Theresa, additional, Makhari, Senamile, additional, Ismael, Nalia, additional, Giaquinto, Carlo, additional, Rossi, Paolo, additional, Kuhn, Louise, additional, Palma, Paolo, additional, Spyer, Moira J., additional, Lichterfeld, Matthias, additional, Nastouli, Eleni, additional, Gianuzzi, Viviana, additional, Ballesteros, Álvaro, additional, Cotugno, Nicola, additional, Morrocchi, Elena, additional, Oletto, Andrea, additional, Tata Traoré, Fatoumata, additional, Dobbels, Els, additional, Akhalwaya, Yasmeen, additional, Ording-Jespersen, Gregory, additional, Foster, Caroline, additional, Rabie, Helena, additional, Amuge, Pauline, additional, Brehin, Camille, additional, Pahwa, Savita, additional, Coulibaly, Yacouba Aba, additional, Rojo, Pablo, additional, and Consortium, EPIICAL, additional
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- 2023
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20. Altered phenotype and function of NK cells infiltrating Human Papillomavirus (HPV)-associated genital warts during HIV infection
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Bere, Alfred, Tayib, Shahila, Kriek, Jean-Mari, Masson, Lindi, Jaumdally, Shameem Z., Barnabas, Shaun L., Carr, William H., Allan, Bruce, Williamson, Anna-Lise, Denny, Lynette, and Passmore, Jo-Ann S.
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- 2014
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21. Antimicrobial and inflammatory properties of South African clinical Lactobacillus isolates and vaginal probiotics
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Chetwin, Emily, Manhanzva, Monalisa T., Abrahams, Andrea G., Froissart, Remy, Gamieldien, Hoyam, Jaspan, Heather, Jaumdally, Shameem Z., Barnabas, Shaun L., Dabee, Smritee, Happel, Anna-Ursula, Bowers, Desiree, Davids, Lester, Passmore, Jo-Ann S., and Masson, Lindi
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- 2019
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22. Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection
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Balle, Christina, Lennard, Katie, Dabee, Smritee, Barnabas, Shaun L., Jaumdally, Shameem Z., Gasper, Melanie A., Maseko, Venessa, Mbulawa, Zizipho Z. A., Williamson, Anna-Lise, Bekker, Linda-Gail, Lewis, David A., Passmore, Jo-Ann S., and Jaspan, Heather B.
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- 2018
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23. Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysis of a randomised, phase 1b–2a trial
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Madhi, Shabir A, primary, Kwatra, Gaurav, additional, Richardson, Simone I, additional, Koen, Anthonet L, additional, Baillie, Vicky, additional, Cutland, Clare L, additional, Fairlie, Lee, additional, Padayachee, Sherman D, additional, Dheda, Keertan, additional, Barnabas, Shaun L, additional, Bhorat, Qasim Ebrahim, additional, Briner, Carmen, additional, Ahmed, Khatija, additional, Aley, Parvinder K, additional, Bhikha, Sutika, additional, Bhorat, A E, additional, Esmail, Aliasgar, additional, Horne, Elizea, additional, Kaldine, Haajira, additional, Mukendi, Christian K, additional, Madzorera, Vimbai Sharon, additional, Manamela, Nelia P, additional, Masilela, Mduduzi, additional, Hermanus, S Tandile, additional, Motlou, Thopisang, additional, Mzindle, Nonkululeko, additional, Oelofse, Suzette, additional, Patel, Faeezah, additional, Rhead, Sarah, additional, Rossouw, Lindie, additional, Taoushanis, Carol, additional, van Eck, Samuel, additional, Lambe, Teresa, additional, Gilbert, Sarah C, additional, Pollard, Andrew J, additional, Moore, Penny L, additional, and Izu, Alane, additional
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- 2022
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24. Single Dose Administration, And The Influence Of The Timing Of The Booster Dose On Immunogenicity and Efficacy Of ChAdOx1 nCoV-19 (AZD1222) Vaccine
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Voysey, Merryn, Costa Clemens, Sue Ann, Madhi, Shabir A, Weckx, Lily Yin, Folegatti, Pedro M, Aley, Parvinder K, Angus, Brian John, Baillie, Vicky, Barnabas, Shaun L, Bhorat, Qasim E, Bibi, Sagida, Briner, Carmen, Cicconi, Paola, Clutterbuck, Elizabeth, Collins, Andrea M, Cutland, Clare, Darton, Thomas, Dheda, Keertan, Douglas, Alexander D, Duncan, Christopher JA, Emary, Katherine RW, Ewer, Katie, Flaxman, Amy, Fairlie, Lee, Faust, Saul N, Feng, Shuo, Ferreira, Daniela M, Finn, Adam, Galiza, Eva, Goodman, Anna L, Green, Catherine M, Green, Christopher A, Greenland, Melanie, Hill, Catherine, Hill, Helen C, Hirsch, Ian, Izu, Alane, Jenkin, Daniel, Kerridge, Simon, Koen, Anthonet, Kwatra, Gaurav, Lazarus, Rajeka, Libri, Vincenzo, Lillie, Patrick J, Marchevsky, Natalie, Marshall, Richard P, Mendes, Ana Verena Almeida, Milan, Eveline P, Minassian, Angela M, McGregor, Alastair C, Farooq Mujadidi, Yama, Nana, Anusha, Payadachee, Sherman D, Phillips, Daniel J, Pittella, Ana, Plested, Emma, Pollock, Katrina M, Ramasamy, Maheshi N, Robinson, Hannah, Schwarzbold, Alexandre V, Smith, Andrew, Song, Rinn, Snape, Matthew D, Sprinz, Eduardo, Sutherland, Rebecca K, Thomson, Emma C, Török, Mili Estée, Toshner, Mark, Turner, David PJ, Vekemans, Johan, Villafana, Tonya L, White, Thomas, Williams, Christopher J, Hill, Adrian VS, Lambe, Teresa, Gilbert, Sarah C, Pollard, Andrew, and Group, Oxford COVID Vaccine Trial
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- 2022
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25. Efficacy of the AZD1222 (ChAdOx1 nCoV-19) COVID-19 Vaccine Against SARS-CoV-2 Variants of Concern
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Koen, Anthonet L., primary, Izu, Alane, additional, Baillie, Vicky, additional, Kwatra, Gaurav, additional, Cutland, Clare L., additional, Fairlie, Lee, additional, Padayachee, Sherman D., additional, Dheda, Keertan, additional, Barnabas, Shaun L., additional, Bhorat, Qasim Ebrahim, additional, Briner, Carmen, additional, Ahmed, Khatija, additional, Bhikha, Sutika, additional, Bhiman, Jinal N., additional, Plessis, Jeanine du, additional, Esmail, Aliasgar, additional, Horne, Elizea, additional, Hwa, Shi-Hsia, additional, Oommen-Jose, Aylin, additional, Lambe, Teresa, additional, Laubscher, Matt, additional, Malahleha, Mookho, additional, Benade, Gabriella, additional, McKenzie, Shakeel, additional, Oelofse, Suzette, additional, Patel, Faeezah, additional, Pillay, Sureshnee, additional, Rhead, Sarah, additional, Rodel, Hylton, additional, Taoushanis, Carol, additional, Tegally, Houriiyah, additional, Thombrayil, Asha, additional, Villafana, Tonya L., additional, Gilbert, Sarah, additional, Pollard, Andrew J., additional, and Madhi, Shabir A., additional
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- 2022
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26. Systems Analysis Reveals Contraceptive-Induced Alteration of Cervicovaginal Gene Expression in a Randomized Trial
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Balle, Christina, primary, Gupta, Prachi M., additional, Tharp, Gregory K., additional, Nelson, Sydney A., additional, Konstantinus, Iyaloo N., additional, Lennard, Katie, additional, Jaumdally, Shameem Z., additional, Happel, Anna-Ursula, additional, Barnabas, Shaun L., additional, Gill, Katherine, additional, Bekker, Linda-Gail, additional, Passmore, Jo-Ann S., additional, Jaspan, Heather B., additional, and Bosinger, Steven E., additional
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- 2022
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27. Anaemia, iron and vitamin A status among South African school-aged children living with and without HIV
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Goosen, Charlene, Baumgartner, Jeannine, Mikulic, Nadja, Barnabas, Shaun L., Cotton, Mark F., Zimmermann, Michael B., and Blaauw, Renée
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Background. Data on iron and vitamin A deficiency are scarce in school-aged children living with HIV (HIV+) compared with children without HIV (HIV-). Both deficiencies can contribute to anaemia., Objective. To assess anaemia, iron and vitamin A status in a sample of HIV+ and HIV- school-aged children in South Africa., Methods. In this comparative cross-sectional study, biomarkers for anaemia (haemoglobin), iron (plasma ferritin (PF), soluble transferrin receptor), vitamin A (retinol-binding protein (RBP)) and inflammatory status (C-reactive protein, alpha-1-acid glycoprotein) were measured in 8 - 13-year-old children from Cape Town living with (n=143) and without HIV (n=148). Measurements of PF and RBP were adjusted for inflammation using a regression-correction approach., Results. HIV+ children had higher prevalences of anaemia (29% v. 14%; odds ratio (OR) = 2.6; 95% confidence interval (CI) 1.4 - 4.9; p=0.002), iron-deficient erythropoiesis (20% v. 9%; OR=2.5; 95% CI 1.2 - 5.0; p=0.013) and iron deficiency anaemia (11% v. 4%; OR=2.9; 95% CI 1.1 - 7.7; p=0.035) than HIV- children. Marginal vitamin A deficiency was noted in 52% of HIV+ and 57% of HIV- children (p=0.711). Subclinical inflammation was more prevalent in HIV+ than HIV- children (p=0.012)., Conclusion. Anaemia, iron-deficient erythropoiesis and iron deficiency anaemia were more prevalent in HIV+ than HIV- children. Prevalence of marginal vitamin A deficiency was high in both groups. Efforts to improve micronutrient status and mitigate nutritional determinants of anaemia in HIV+ children from resource-limited settings should be prioritised., South African Journal of Child Health, 16 (2)
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28. Durability of ChAdOx1 nCoV-19 (AZD1222) Vaccine and Hybrid Humoral Immunity Against Variants Including Omicron BA.1 and BA.4 Six Months after Vaccination: A Randomised, Phase 1b/2a Trial
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Madhi, Shabir A., primary, Kwatra, Gaurav, additional, Welch, Richard, additional, Koen, Anthonet L., additional, Baillie, Vicky L., additional, Cutland, Clare, additional, Fairlie, Lee, additional, Padayachee, Sherman D., additional, Dheda, Keertan, additional, Barnabas, Shaun L., additional, Bhorat, Qasim Ebrahim, additional, Briner, Carmen, additional, Ahmed, Khatija, additional, Aley, Parvinder K., additional, Bhikha, Sutika, additional, Bhorat, As'ad Ebrahim, additional, Esmail, Aliasgar, additional, Horne, Elizea, additional, Kaldine, Haajira, additional, Mukendi, Christian K., additional, Madzorera, Vimbai Sharon, additional, Manamela, Nelia P., additional, Masilela, Mduduzi, additional, Hermanus, Tandile, additional, Motlou, Thopisang, additional, Mzindle, Nonkululeko, additional, Oelofse, Suzette, additional, Patel, Faeezah, additional, Rhead, Sarah, additional, Rossouw, Lindie, additional, Taoushanis, Carol, additional, van Eck, Samuel, additional, Lambe, Teresa, additional, Gilbert, Sarah C., additional, Pollard, Andrew J., additional, Moore, Penny L., additional, and Izu, Alane, additional
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- 2022
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29. Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant
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Madhi, Shabir A, Baillie, Vicky, Cutland, Clare L, Voysey, Merryn, Koen, Anthonet L, Fairlie, Lee, Padayachee, Sherman D, Dheda, Keertan, Barnabas, Shaun L, Bhorat, Qasim E, Briner, Carmen, Kwatra, Gaurav, Ahmed, Khatija, Aley, Parvinder, Bhikha, Sutika, Bhiman, Jinal N, Bhorat, As'ad E, du Plessis, Jeanine, Esmail, Aliasgar, Groenewald, Marisa, Horne, Elizea, Hwa, Shi-Hsia, Jose, Aylin, Lambe, Teresa, Laubscher, Matt, Malahleha, Mookho, Masenya, Masebole, Masilela, Mduduzi, McKenzie, Shakeel, Molapo, Kgaogelo, Moultrie, Andrew, Oelofse, Suzette, Patel, Faeezah, Pillay, Sureshnee, Rhead, Sarah, Rodel, Hylton, Rossouw, Lindie, Taoushanis, Carol, Tegally, Houriiyah, Thombrayil, Asha, van Eck, Samuel, Wibmer, Constantinos K, Durham, Nicholas M, Kelly, Elizabeth J, Villafana, Tonya L, Gilbert, Sarah, Pollard, Andrew J, de Oliveira, Tulio, Moore, Penny L, Sigal, Alex, Izu, Alane, NGS-SA Group, and Wits-VIDA COVID Group
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BACKGROUND: Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV-2 variants of concern, including the B.1.351 (501Y.V2) variant first identified in South Africa. METHODS: We conducted a multicenter, double-blind, randomized, controlled trial to assess the safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) in people not infected with the human immunodeficiency virus (HIV) in South Africa. Participants 18 to less than 65 years of age were assigned in a 1:1 ratio to receive two doses of vaccine containing 5×1010 viral particles or placebo (0.9% sodium chloride solution) 21 to 35 days apart. Serum samples obtained from 25 participants after the second dose were tested by pseudovirus and live-virus neutralization assays against the original D614G virus and the B.1.351 variant. The primary end points were safety and efficacy of the vaccine against laboratory-confirmed symptomatic coronavirus 2019 illness (Covid-19) more than 14 days after the second dose. RESULTS: Between June 24 and November 9, 2020, we enrolled 2026 HIV-negative adults (median age, 30 years); 1010 and 1011 participants received at least one dose of placebo or vaccine, respectively. Both the pseudovirus and the live-virus neutralization assays showed greater resistance to the B.1.351 variant in serum samples obtained from vaccine recipients than in samples from placebo recipients. In the primary end-point analysis, mild-to-moderate Covid-19 developed in 23 of 717 placebo recipients (3.2%) and in 19 of 750 vaccine recipients (2.5%), for an efficacy of 21.9% (95% confidence interval [CI], -49.9 to 59.8). Among the 42 participants with Covid-19, 39 cases (95.1% of 41 with sequencing data) were caused by the B.1.351 variant; vaccine efficacy against this variant, analyzed as a secondary end point, was 10.4% (95% CI, -76.8 to 54.8). The incidence of serious adverse events was balanced between the vaccine and placebo groups. CONCLUSIONS: A two-dose regimen of the ChAdOx1 nCoV-19 vaccine did not show protection against mild-to-moderate Covid-19 due to the B.1.351 variant. (Funded by the Bill and Melinda Gates Foundation and others; ClinicalTrials.gov number, NCT04444674; Pan African Clinical Trials Registry number, PACTR202006922165132).
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- 2021
30. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
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Voysey, Merryn, Costa Clemens, Sue Ann, Madhi, Shabir A, Weckx, Lily Y, Folegatti, Pedro M, Aley, Parvinder K, Angus, Brian, Baillie, Vicky L, Barnabas, Shaun L, Bhorat, Qasim E, Bibi, Sagida, Briner, Carmen, Cicconi, Paola, Clutterbuck, Elizabeth A, Collins, Andrea M, Cutland, Clare L, Darton, Thomas C, Dheda, Keertan, Dold, Christina, Duncan, Christopher JA, Emary, Katherine RW, Ewer, Katie J, Flaxman, Amy, Fairlie, Lee, Faust, Saul N, Feng, Shuo, Ferreira, Daniela M, Finn, Adam, Galiza, Eva, Goodman, Anna L, Green, Catherine M, Green, Christopher A, Greenland, Melanie, Hill, Catherine, Hill, Helen C, Hirsch, Ian, Izu, Alane, Jenkin, Daniel, Joe, Carina CD, Kerridge, Simon, Koen, Anthonet, Kwatra, Gaurav, Lazarus, Rajeka, Libri, Vincenzo, Lillie, Patrick J, Marchevsky, Natalie G, Marshall, Richard P, Mendes, Ana VA, Milan, Eveline P, Minassian, Angela M, McGregor, Alastair, Mujadidi, Yama F, Nana, Anusha, Padayachee, Sherman D, Phillips, Daniel J, Pittella, Ana, Plested, Emma, Pollock, Katrina M, Ramasamy, Maheshi N, Ritchie, Adam J, Robinson, Hannah, Schwarzbold, Alexandre V, Smith, Andrew, Song, Rinn, Snape, Matthew D, Sprinz, Eduardo, Sutherland, Rebecca K, Thomson, Emma C, Török, M Estée, Toshner, Mark, Turner, David PJ, Vekemans, Johan, Villafana, Tonya L, White, Thomas, Williams, Christopher J, Douglas, Alexander D, Hill, Adrian VS, Lambe, Teresa, Gilbert, Sarah C, Pollard, Andrew J, and Oxford COVID Vaccine Trial Group
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Background\ud The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks. The planned roll-out in the UK will involve vaccinating people in high-risk categories with their first dose immediately, and delivering the second dose 12 weeks later. Here, we provide both a further prespecified pooled analysis of trials of ChAdOx1 nCoV-19 and exploratory analyses of the impact on immunogenicity and efficacy of extending the interval between priming and booster doses. In addition, we show the immunogenicity and protection afforded by the first dose, before a booster dose has been offered.MethodsWe present data from three single-blind randomised controlled trials-one phase 1/2 study in the UK (COV001), one phase 2/3 study in the UK (COV002), and a phase 3 study in Brazil (COV003)-and one double-blind phase 1/2 study in South Africa (COV005). As previously described, individuals 18 years and older were randomly assigned 1:1 to receive two standard doses of ChAdOx1 nCoV-19 (5 × 1010 viral particles) or a control vaccine or saline placebo. In the UK trial, a subset of participants received a lower dose (2·2 × 1010 viral particles) of the ChAdOx1 nCoV-19 for the first dose. The primary outcome was virologically confirmed symptomatic COVID-19 disease, defined as a nucleic acid amplification test (NAAT)-positive swab combined with at least one qualifying symptom (fever ≥37·8°C, cough, shortness of breath, or anosmia or ageusia) more than 14 days after the second dose. Secondary efficacy analyses included cases occuring at least 22 days after the first dose. Antibody responses measured by immunoassay and by pseudovirus neutralisation were exploratory outcomes. All cases of COVID-19 with a NAAT-positive swab were adjudicated for inclusion in the analysis by a masked independent endpoint review committee. The primary analysis included all participants who were SARS-CoV-2 N protein seronegative at baseline, had had at least 14 days of follow-up after the second dose, and had no evidence of previous SARS-CoV-2 infection from NAAT swabs. Safety was assessed in all participants who received at least one dose. The four trials are registered at ISRCTN89951424 (COV003) and ClinicalTrials.gov, NCT04324606 (COV001), NCT04400838 (COV002), and NCT04444674 (COV005).FindingsBetween April 23 and Dec 6, 2020, 24 422 participants were recruited and vaccinated across the four studies, of whom 17 178 were included in the primary analysis (8597 receiving ChAdOx1 nCoV-19 and 8581 receiving control vaccine). The data cutoff for these analyses was Dec 7, 2020. 332 NAAT-positive infections met the primary endpoint of symptomatic infection more than 14 days after the second dose. Overall vaccine efficacy more than 14 days after the second dose was 66·7% (95% CI 57·4-74·0), with 84 (1·0%) cases in the 8597 participants in the ChAdOx1 nCoV-19 group and 248 (2·9%) in the 8581 participants in the control group. There were no hospital admissions for COVID-19 in the ChAdOx1 nCoV-19 group after the initial 21-day exclusion period, and 15 in the control group. 108 (0·9%) of 12 282 participants in the ChAdOx1 nCoV-19 group and 127 (1·1%) of 11 962 participants in the control group had serious adverse events. There were seven deaths considered unrelated to vaccination (two in the ChAdOx1 nCov-19 group and five in the control group), including one COVID-19-related death in one participant in the control group. Exploratory analyses showed that vaccine efficacy after a single standard dose of vaccine from day 22 to day 90 after vaccination was 76·0% (59·3-85·9). Our modelling analysis indicated that protection did not wane during this initial 3-month period. Similarly, antibody levels were maintained during this period with minimal waning by day 90 (geometric mean ratio [GMR] 0·66 [95% CI 0·59-0·74]). In the participants who received two standard doses, after the second dose, efficacy was higher in those with a longer prime-boost interval (vaccine efficacy 81·3% [95% CI 60·3-91·2] at ≥12 weeks) than in those with a short interval (vaccine efficacy 55·1% [33·0-69·9] at InterpretationThe results of this primary analysis of two doses of ChAdOx1 nCoV-19 were consistent with those seen in the interim analysis of the trials and confirm that the vaccine is efficacious, with results varying by dose interval in exploratory analyses. A 3-month dose interval might have advantages over a programme with a short dose interval for roll-out of a pandemic vaccine to protect the largest number of individuals in the population as early as possible when supplies are scarce, while also improving protection after receiving a second dose.FundingUK Research and Innovation, National Institutes of Health Research (NIHR), The Coalition for Epidemic Preparedness Innovations, the Bill & Melinda Gates Foundation, the Lemann Foundation, Rede D'Or, the Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca.
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- 2021
31. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
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Voysey, Merryn, Clemens, Sue Ann Costa, Madhi, Shabir A., Weckx, Lily Y., Folegatti, Pedro M., Aley, Parvinder K., Angus, Brian, Baillie, Vicky L., Barnabas, Shaun L., Bhorat, Qasim E., Bibi, Sagida, Briner, Carmen, Cicconi, Paola, Collins, Andrea M., Colin-Jones, Rachel, Cutland, Clare L., Darton, Thomas C., Dheda, Keertan, Duncan, Christopher J. A., Emary, Katherine R. W., Ewer, Katie J., Fairlie, Lee, Faust, Saul N., Feng, Shuo, Ferreira, Daniela M., Finn, Adam, Goodman, Anna L., Green, Catherine M., Green, Christopher A., Heath, Paul T., Hill, Catherine, Hill, Helen, Hirsch, Ian, Hodgson, Susanne H. C., Izu, Alane, Jackson, Susan, Jenkin, Daniel, Joe, Carina C. D., Kerridge, Simon, Koen, Anthonet, Kwatra, Gaurav, Lazarus, Rajeka, Lawrie, Alison M., Lelliott, Alice, Libri, Vincenzo, Lillie, Patrick J., Mallory, Raburn, Mendes, Ana V. A., Milan, Eveline P., Minassian, Angela M., McGregor, Alastair, Morrison, Hazel, Mujadidi, Yama F., Nana, Anusha, O'Reilly, Peter J., Padayachee, Sherman D., Pittella, Ana, Plested, Emma, Pollock, Katrina M., Ramasamy, Maheshi N., Rhead, Sarah, Schwarzbold, Alexandre V., Singh, Nisha, Smith, Andrew, Song, Rinn, Snape, Matthew D., Sprinz, Eduardo, Sutherland, Rebecca K., Tarrant, Richard, Thomson, Emma C., Török, Mark and Turner, Sorio, Guilherme L., Sorley, Kim, Sosa-Rodriguez, Tiffany, Souza, Cinthia M.C.D.L., Souza, Bruno S.D.F., Souza, Alessandra R., Spencer, Alexandra J., Spina, Fernanda, Spoors, Louise, Stafford, Lizzie, Stamford, Imogen, Starinskij, Igor, Stein, Ricardo, Steven, Jill, Stockdale, Lisa, Stockwell, Lisa V., Strickland, Louise H., Stuart, Arabella C., Sturdy, Ann, Sutton, Natalina, Szigeti, Anna, Tahiri-Alaoui, Abdessamad, Tanner, Rachel, Taoushanis, Carol, Tarr, Alexander W., Taylor, Keja, Taylor, Ursula, Taylor, Iona Jennifer, Taylor, Justin, te Water Naude, Rebecca, Themistocleous, Yrene, Themistocleous, Andreas, Thomas, Merin, Thomas, Kelly, Thomas, Tonia M., Thombrayil, Asha, Thompson, Fawziyah, Thompson, Amber, Thompson, Kevin, Thompson, Ameeka, Thomson, Julia, Thornton-Jones, Viv, Tighe, Patrick J., Tinoco, Lygia Accioly, Tiongson, Gerlynn, Tladinyane, Bonolo, Tomasicchio, Michele, Tomic, Adriana, Tonks, Susan, Tran, Nguyen, Tree, Julia, Trillana, Gerry, Trinham, Charlotte, Trivett, Rose, Truby, Adam, Tsheko, Betty Lebogang, Turabi, Aadil, Turner, Richard, Turner, Cheryl, Ulaszewska, Marta, Underwood, Benjamin R., Varughese, Rachel, Verbart, Dennis, Verheul, Marije, Vichos, Iason, Vieira, Taiane, Waddington, Claire S., Walker, Laura, Wallis, Erica, Wand, Matthew, Warbick, Deborah, Wardell, Theresa, Warimwe, George, Warren, Sarah C., Watkins, Bridget, Watson, Ekaterina, Webb, Stewart, Webb-Bridges, Alice, Webster, Angela, Welch, Jessica, Wells, Jeanette, West, Alison, White, Caroline, White, Rachel, Williams, Paul, Williams, Rachel L., Winslow, Rebecca, Woodyer, Mark, Worth, Andrew T., Wright, Danny, Wroblewska, Marzena, Yao, Andy, Zimmer, Rafael, Zizi, Dalila, and Zuidewind, Peter
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Background: \ud A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.\ud \ud Methods: \ud This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674.\ud \ud Findings: \ud Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation.\ud \ud Interpretation: \ud ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials.\ud \ud Funding: \ud UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D’Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca.
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- 2021
32. Examining Associations of HIV and Iron Status with Nutritional and Inflammatory Status, Anemia, and Dietary Intake in South African Schoolchildren
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Goosen, Charlene, primary, Baumgartner, Jeannine, additional, Mikulic, Nadja, additional, Barnabas, Shaun L., additional, Cotton, Mark F., additional, Zimmermann, Michael B., additional, and Blaauw, Renée, additional
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- 2021
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33. Single Dose Administration, And The Influence Of The Timing Of The Booster Dose On Immunogenicity and Efficacy Of ChAdOx1 nCoV-19 (AZD1222) Vaccine
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Voysey, Merryn, primary, Costa Clemens, Sue Ann, additional, Madhi, Shabir A., additional, Weckx, Lily Yin, additional, Folegatti, Pedro M., additional, Aley, Parvinder K., additional, Angus, Brian John, additional, Baillie, Vicky, additional, Barnabas, Shaun L., additional, Bhorat, Qasim E., additional, Bibi, Sagida, additional, Briner, Carmen, additional, Cicconi, Paola, additional, Clutterbuck, Elizabeth, additional, Collins, Andrea M., additional, Cutland, Clare, additional, Darton, Thomas, additional, Dheda, Keertan, additional, Douglas, Alexander D., additional, Duncan, Christopher J. A., additional, Emary, Katherine R. W., additional, Ewer, Katie, additional, Flaxman, Amy, additional, Fairlie, Lee, additional, Faust, Saul N., additional, Feng, Shuo, additional, Ferreira, Daniela M., additional, Finn, Adam, additional, Galiza, Eva, additional, Goodman, Anna L., additional, Green, Catherine M., additional, Green, Christopher A., additional, Greenland, Melanie, additional, Hill, Catherine, additional, Hill, Helen C., additional, Hirsch, Ian, additional, Izu, Alane, additional, Jenkin, Daniel, additional, Kerridge, Simon, additional, Koen, Anthonet, additional, Kwatra, Gaurav, additional, Lazarus, Rajeka, additional, Libri, Vincenzo, additional, Lillie, Patrick J., additional, Marchevsky, Natalie G., additional, Marshall, Richard P., additional, Mendes, Ana Verena Almeida, additional, Milan, Eveline P., additional, Minassian, Angela M., additional, McGregor, Alastair C., additional, Farooq Mujadidi, Yama, additional, Nana, Anusha, additional, Payadachee, Sherman D., additional, Phillips, Daniel J., additional, Pittella, Ana, additional, Plested, Emma, additional, Pollock, Katrina M., additional, Ramasamy, Maheshi N., additional, Robinson, Hannah, additional, Schwarzbold, Alexandre V., additional, Smith, Andrew, additional, Song, Rinn, additional, Snape, Matthew D., additional, Sprinz, Eduardo, additional, Sutherland, Rebecca K., additional, Thomson, Emma C., additional, Torok, Mili, additional, Toshner, Mark, additional, Turner, David P. J., additional, Vekemans, Johan, additional, Villafana, Tonya L., additional, White, Thomas, additional, Williams, Christopher J., additional, Hill, Adrian V. S., additional, Lambe, Teresa, additional, Gilbert, Sarah C., additional, Pollard, Andrew, additional, and Group, Oxford COVID Vaccine Trial, additional
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34. Hormonal contraception and risk of STIs and bacterial vaginosis in South African adolescents: secondary analysis of a randomised trial
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Balle, Christina, primary, Gill, Katherine, additional, Konstantinus, Iyaloo N, additional, Jaumdally, Shameem Z, additional, Lennard, Katie, additional, Esra, Rachel, additional, Happel, Anna-Ursula, additional, Barnabas, Shaun L, additional, Gamieldien, Hoyam, additional, Pidwell, Tanya, additional, Maseko, Venessa, additional, Lesosky, Maia, additional, Myer, Landon, additional, Passmore, Jo-Ann S, additional, Bekker, Linda-Gail, additional, and Jaspan, Heather B, additional
- Published
- 2020
- Full Text
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35. Relationship between the Oral and Vaginal Microbiota of South African Adolescents with High Prevalence of Bacterial Vaginosis
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Balle, Christina, primary, Esra, Rachel, additional, Havyarimana, Enock, additional, Jaumdally, Shameem Z., additional, Lennard, Katie, additional, Konstantinus, Iyaloo N., additional, Barnabas, Shaun L., additional, Happel, Anna-Ursula, additional, Gill, Katherine, additional, Pidwell, Tanya, additional, Lingappa, Jairam R., additional, Gamieldien, Hoyam, additional, Bekker, Linda-Gail, additional, Passmore, Jo-Ann S., additional, and Jaspan, Heather B., additional
- Published
- 2020
- Full Text
- View/download PDF
36. Exploring potential of vaginal Lactobacillus isolates from South African women for enhancing treatment for bacterial vaginosis
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Happel, Anna-Ursula, primary, Kullin, Brian, additional, Gamieldien, Hoyam, additional, Wentzel, Nicole, additional, Zauchenberger, Chambrez Z., additional, Jaspan, Heather B., additional, Dabee, Smritee, additional, Barnabas, Shaun L., additional, Jaumdally, Shameem Z., additional, Dietrich, Janan, additional, Gray, Glenda, additional, Bekker, Linda-Gail, additional, Froissart, Remy, additional, and Passmore, Jo-Ann S., additional
- Published
- 2020
- Full Text
- View/download PDF
37. Results from the first South African Health Products Regulatory Authority-approved randomised trial evaluating supplementation of standard antibiotic therapy with a commercially available probiotic in South African women with bacterial vaginosis
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Happel, Anna-Ursula, primary, Singh, Ravesh, additional, Mitchev, Nireshni, additional, Mlisana, Koleka, additional, Jaspan, Heather B., additional, Barnabas, Shaun L., additional, and Passmore, Jo-Ann S., additional
- Published
- 2020
- Full Text
- View/download PDF
38. Additional file 1 of Testing the regulatory framework in South Africa – a single-blind randomized pilot trial of commercial probiotic supplementation to standard therapy in women with bacterial vaginosis
- Author
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Happel, Anna-Ursula, Ravesh Singh, Nireshni Mitchev, Koleka Mlisana, Jaspan, Heather B., Barnabas, Shaun L., and Jo-Ann S. Passmore
- Abstract
Additional file 1. Participant questionnaires. Questionnaires administered to the participants to capture data on demographics, women’s reproductive and sexual health, use and preference of study products.
- Published
- 2020
- Full Text
- View/download PDF
39. Geografiese ligging beïnvloed vaginale mikrobiese profiele in Suid-Afrikaanse vroue
- Author
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Lennard, Katie S, primary, Dabee, Smritee, additional, Barnabas, Shaun L, additional, Havyarimana, Enock, additional, Blakney, Anna, additional, Jaumdally, Shameem, additional, Botha, Gerrit, additional, Mkhize, Nonhlanhla, additional, Bekker, Linda-Gail, additional, Lewis, David, additional, Gray, Glenda, additional, Mulder, Nicola, additional, Passmore, Jo-Ann, additional, and Jaspan, Heather, additional
- Published
- 2019
- Full Text
- View/download PDF
40. Tuberculosis and HIV—An Update on the “Cursed Duet” in Children
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Fry, Samantha H.-L., primary, Barnabas, Shaun L., additional, and Cotton, Mark F., additional
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- 2019
- Full Text
- View/download PDF
41. Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection
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Dabee, Smritee, primary, Barnabas, Shaun L., additional, Lennard, Katie S., additional, Jaumdally, Shameem Z., additional, Gamieldien, Hoyam, additional, Balle, Christina, additional, Happel, Anna-Ursula, additional, Murugan, Brandon D., additional, Williamson, Anna-Lise, additional, Mkhize, Nonhlanhla, additional, Dietrich, Janan, additional, Lewis, David A., additional, Chiodi, Francesca, additional, Hope, Thomas J., additional, Shattock, Robin, additional, Gray, Glenda, additional, Bekker, Linda-Gail, additional, Jaspan, Heather B., additional, and Passmore, Jo-Ann S., additional
- Published
- 2019
- Full Text
- View/download PDF
42. Hormonal contraception and risk of STIs and bacterial vaginosis in South African adolescents: secondary analysis of a randomised trial.
- Author
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Balle, Christina, Gill, Katherine, Konstantinus, Iyaloo N., Jaumdally, Shameem Z., Lennard, Katie, Esra, Rachel, Happel, Anna-Ursula, Barnabas, Shaun L., Gamieldien, Hoyam, Pidwell, Tanya, Maseko, Venessa, Lesosky, Maia, Myer, Landon, Passmore, Jo-Ann S., Bekker, Linda-Gail, and Jaspan, Heather B.
- Abstract
Objectives: Young women in sub-Saharan Africa are at high risk of STIs and unintended pregnancies, yet hormonal contraceptive (HC) use may affect STI risk. We compared the influence of three HCs on the incidence and prevalence of STIs and bacterial vaginosis (BV) in South African adolescents.Methods: One hundred and thirty adolescents between 15 and 19 years were randomised to the injectable norethisterone enanthate (Net-En), combined oral contraceptives (COC) (Triphasil or Nordette) or a combined contraceptive vaginal ring (CCVR; NuvaRing) for 16 weeks (clinicaltrials.gov/NCT02404038). Vaginal samples were collected at baseline and 16 weeks post contraceptive initiation for STI and BV testing.Results: In an intention-to-treat analysis, no significant differences in BV prevalence were found between study arms. The overall incidence of any STI at follow-up was high: 16.2% in the COC arm; 25.7% in the Net-En arm; and 37.1% in the CCVR arm. The incidence rate (IR) of any STI was similar between Net-En (IR 0.74 (95% CI 0.34 to 1.41)) and the oestrogen-containing contraceptives (IR 0.78 (95% CI 0.47 to 1.22)). A lower IR of Chlamydia trachomatis (incidence rate ratio (IRR) 0.68 (95% CI 0.19 to 1.99)) and Neisseria gonorrhoeae (IRR 0.25 (95% CI 0.01 to 1.35)) but a higher IR of Mycoplasma genitalium (IRR 16.0 (95% CI 2.96 to 400)), was observed in the Net-En arm compared with the oestrogen-containing contraceptives, although the overall incidence of M. genitalium was low (4.7%). In an exploratory analysis, the risk of any STI and N. gonorrhoeae was lower in the COC arm compared with CCVR. A per-protocol analysis yielded similar results.Conclusion: Our results suggest that use of Net-En may be associated with increased risk of M. genitalium compared with oestrogen-containing contraceptives but not with overall STI risk. COC use may decrease STI risk relative to CCVR. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
43. Microbial Composition Predicts Genital Tract Inflammation and Persistent Bacterial Vaginosis in South African Adolescent Females
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Lennard, Katie, primary, Dabee, Smritee, additional, Barnabas, Shaun L., additional, Havyarimana, Enock, additional, Blakney, Anna, additional, Jaumdally, Shameem Z., additional, Botha, Gerrit, additional, Mkhize, Nonhlanhla N., additional, Bekker, Linda-Gail, additional, Lewis, David A., additional, Gray, Glenda, additional, Mulder, Nicola, additional, Passmore, Jo-Ann S., additional, and Jaspan, Heather B., additional
- Published
- 2018
- Full Text
- View/download PDF
44. High rates of bacterial vaginosis and Chlamydia in a low-income, high-population-density community in Cape Town
- Author
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Lennard, Katie S., primary, Dabee, Smritee, additional, Barnabas, Shaun L., additional, Havyarimana, Enock, additional, Jaumdally, Shameem Z., additional, Botha, Gerrit, additional, Mkhize, Nonhlanhla N., additional, Bekker, Linda-Gail, additional, Gray, Glenda, additional, Mulder, Nicola, additional, Passmore, Jo-Ann, additional, and Jaspan, Heather B., additional
- Published
- 2017
- Full Text
- View/download PDF
45. Hoë voorkomskoers van bakteriële vaginose en Chlamydia in ’n lae-inkomste, hoë-bevolkingsdigtheid gemeenskap in Kaapstad
- Author
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Lennard, Katie S., primary, Dabee, Smritee, additional, Barnabas, Shaun L., additional, Havyarimana, Enock, additional, Jaumdally, Shameem Z., additional, Botha, Gerrit, additional, Mkhize, Nonhlanhla N., additional, Bekker, Linda-Gail, additional, Gray, Glenda, additional, Mulder, Nicola, additional, Passmore, Jo-Ann, additional, and Jaspan, Heather B., additional
- Published
- 2017
- Full Text
- View/download PDF
46. Probiotics for vaginal health in South Africa: what is on retailers’ shelves?
- Author
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Happel, Anna-Ursula, primary, Jaumdally, Shameem Z., additional, Pidwell, Tanya, additional, Cornelius, Tracy, additional, Jaspan, Heather B., additional, Froissart, Remy, additional, Barnabas, Shaun L., additional, and Passmore, Jo-Ann S., additional
- Published
- 2017
- Full Text
- View/download PDF
47. Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV.
- Author
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Barnabas, Shaun L., Dabee, Smritee, Passmore, Jo-Ann S., Jaspan, Heather B., Lewis, David A., Jaumdally, Shameem Z., Gamieldien, Hoyam, Masson, Lindi, Muller, Etienne, Maseko, Venessa D., Mkhize, Nonhlanhla, Mbulawa, Zizipho, Williamson, Anna-Lise, Gray, Clive M., Hope, Thomas J., Chiodi, Francesca, Dietrich, Janan, Gray, Glenda, Bekker, Linda-Gail, and Women’s Initiative in Sexual Health (WISH) study team
- Subjects
EPIDEMICS ,SEXUALLY transmitted diseases ,BACTERIAL vaginitis ,TEENAGE girls ,HIV infection risk factors ,HIV infection epidemiology ,HIV prevention ,EPIDEMIOLOGY of sexually transmitted diseases ,HIV seronegativity ,RESEARCH ,RESEARCH methodology ,EVALUATION research ,POVERTY areas ,COMPARATIVE studies ,DISEASE prevalence - Abstract
Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections (STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence HIV risk, behavioral risk factors and prevalence of STIs/BV were compared in HIV-seronegative adolescent females (n = 298; 16-22 years) from two South African communities (Soweto and Cape Town). STIs ( Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, herpes simplex virus (HSV)-1, HSV-2, Treponema pallidum, and Haemophilus ducreyi) were detected by multiplex polymerase chain reaction, human papillomavirus (HPV) by Roche Linear Array, and BV by Nugent scoring. Rates of BV (Nugent ≥7; 46.6%) and HPV (66.8%) were high in both communities. Prevalence of C. trachomatis and N. gonorrhoeae were >2-fold higher in Cape Town than Soweto (Chlamydia: 42% [62/149] versus 18% [26/148], p < 0.0001; gonorrhoea 11% [17/149] versus 5% [7/148], p = 0.05). Only 24% of adolescents with vaginal discharge-causing STIs or BV were symptomatic. In South African adolescents, clinical symptoms compatible with vaginal discharge syndrome had a sensitivity of 23% and specificity of 85% for the diagnosis of discharge-causing STI or BV. In a region with high HIV prevalence and incidence, >70% of young women with treatable conditions that could enhance HIV risk would have been missed because they lacked symptoms associated with syndromic management. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
48. Impact of Persistent Human Papillomavirus (HPV) Infections on Inflammatory Cytokine Levels in the Female Genital Tract: Implications for HIV Risk
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Kriek, Jean-Mari, primary, Jaumdally, Shameem Z., additional, Mbulawa, Zizipho, additional, Gumbi, Pamela P., additional, Masson, Lindi, additional, Barnabas, Shaun L., additional, Coetzee, David, additional, Williamson, Anna-Lise, additional, Little, Francesca, additional, and Passmore, Jo-Ann S., additional
- Published
- 2014
- Full Text
- View/download PDF
49. Immune Activation and HIV Target Cells in the Adolescent Female Genital Tract
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Dabee, Smritee, primary, Jaspan, Heather B., additional, Barnabas, Shaun L., additional, Jaumdally, Shameem Z., additional, Gamieldien, Hoyam, additional, Lewis, David, additional, Bennie, Thola, additional, Phuti, Angel, additional, Gray, Clive M., additional, Williamson, Anna-Lise, additional, Hope, Thomas J., additional, Chiodi, Francesca, additional, Shattock, Robin, additional, Passmore, Jo-Ann S., additional, and Bekker, Linda-Gail, additional
- Published
- 2014
- Full Text
- View/download PDF
50. High rates of bacterial vaginosis and Chlamydia in a low-income, high-population-density community in Cape Town.
- Author
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Dabee, Smritee, Barnabas, Shaun L., Havyarimana, Enock, Jaumdally, Shameem Z., Botha, Gerrit, Mkhize, Nonhlanhla N., Bekker, Linda-Gail, Gray, Glenda, Mulder, Nicola, Passmore, Jo-Ann, Jaspan, Heather B., and Lennard, Katie S.
- Abstract
Young South African women, from resource-poor communities, face several sexual and reproductive health challenges. Here we describe the vaginal microbiota and sexually transmitted infection (STI) prevalence of 102; 16-22-year-old, HIV-negative South African women from a low-income, highpopulation- density community in Cape Town (CPT). Vaginal microbiota were profiled using 16S rRNA amplicon sequencing; bacterial vaginosis (BV) status was established using Nugent scoring and STIs were determined by multiplex polymerase chain reaction. STIs were common, with 55% of women having at least one STI; 41% were infected with high-risk human papilloma virus (HPV) and a further 28% with low-risk HPV; 44% were infected with Chlamydia, 16% of whom had at least one additional STI. Similarly, BV rates were very high, with 55% of women classified as BV-positive (Nugent score -7), 7% as BV-intermediate (Nugent score 3-6) and 38% as BV-negative (Nugent 0-2). Group B Streptococcus (Streptococcus agalactiae), the leading cause of neonatal sepsis, was present in 25% of BV-positive women and 28% of BV-negative women, and was significantly more abundant among BV-negative women. Both Chlamydia infection and BV may adversely affect reproductive health and place these women at additional risk for HIV acquisition. The high abundance of Prevotella amnii, in particular, may increase HIV risk, given its inflammatory capacity. Laboratorybased testing for STIs (Chlamydia and Gonorrhoeae in particular) appear to be warranted in this community, together with further monitoring or treatment of BV. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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