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1. Sialylated Fetuin-A as a candidate predictive biomarker for successful grass pollen allergen immunotherapy

Author

Caillot, Noémie, Bouley, Julien, Jain, Karine, Mariano, Sandrine, Luce, Sonia, Horiot, Stéphane, Airouche, Sabi, Beuraud, Chloé, Beauvallet, Christian, Devillier, Philippe, Chollet-Martin, Sylvie, Kellenberger, Christine, Mascarell, Laurent, Chabre, Henri, Batard, Thierry, Nony, Emmanuel, Lombardi, Vincent, Baron-Bodo, Véronique, and Moingeon, Philippe

Published
2017
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4. Data from Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies

Author

Preillon, Julie, primary, Cuende, Julia, primary, Rabolli, Virginie, primary, Garnero, Lucile, primary, Mercier, Marjorie, primary, Wald, Noémie, primary, Pappalardo, Angela, primary, Denies, Sofie, primary, Jamart, Diane, primary, Michaux, Anne-Catherine, primary, Pirson, Romain, primary, Pitard, Vincent, primary, Bagot, Martine, primary, Prasad, Shruthi, primary, Houthuys, Erica, primary, Brouwer, Margreet, primary, Marillier, Reece, primary, Lambolez, Florence, primary, Marchante, Joäo R., primary, Nyawouame, Florence, primary, Carter, Mathew J., primary, Baron-Bodo, Véronique, primary, Marie-Cardine, Anne, primary, Cragg, Mark, primary, Déchanet-Merville, Julie, primary, Driessens, Gregory, primary, and Hoofd, Catherine, primary

Published
2023
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5. Supp Figures from Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies

Author

Preillon, Julie, primary, Cuende, Julia, primary, Rabolli, Virginie, primary, Garnero, Lucile, primary, Mercier, Marjorie, primary, Wald, Noémie, primary, Pappalardo, Angela, primary, Denies, Sofie, primary, Jamart, Diane, primary, Michaux, Anne-Catherine, primary, Pirson, Romain, primary, Pitard, Vincent, primary, Bagot, Martine, primary, Prasad, Shruthi, primary, Houthuys, Erica, primary, Brouwer, Margreet, primary, Marillier, Reece, primary, Lambolez, Florence, primary, Marchante, Joäo R., primary, Nyawouame, Florence, primary, Carter, Mathew J., primary, Baron-Bodo, Véronique, primary, Marie-Cardine, Anne, primary, Cragg, Mark, primary, Déchanet-Merville, Julie, primary, Driessens, Gregory, primary, and Hoofd, Catherine, primary

Published
2023
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6. Supplementary Data from Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies

Author

Preillon, Julie, primary, Cuende, Julia, primary, Rabolli, Virginie, primary, Garnero, Lucile, primary, Mercier, Marjorie, primary, Wald, Noémie, primary, Pappalardo, Angela, primary, Denies, Sofie, primary, Jamart, Diane, primary, Michaux, Anne-Catherine, primary, Pirson, Romain, primary, Pitard, Vincent, primary, Bagot, Martine, primary, Prasad, Shruthi, primary, Houthuys, Erica, primary, Brouwer, Margreet, primary, Marillier, Reece, primary, Lambolez, Florence, primary, Marchante, Joäo R., primary, Nyawouame, Florence, primary, Carter, Mathew J., primary, Baron-Bodo, Véronique, primary, Marie-Cardine, Anne, primary, Cragg, Mark, primary, Déchanet-Merville, Julie, primary, Driessens, Gregory, primary, and Hoofd, Catherine, primary

Published
2023
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12. Vaccination of melanoma patients using dendritic cells loaded with an allogeneic tumor cell lysate

Author

Salcedo, Margarita, Bercovici, Nadège, Taylor, Rachel, Vereecken, Pierre, Massicard, Séverine, Duriau, Dominique, Vernel-Pauillac, Frédérique, Boyer, Aurélie, Baron-Bodo, Véronique, Mallard, Eric, Bartholeyns, Jacques, Goxe, Béatrice, Latour, Nathalie, Leroy, Sophie, Prigent, Didier, Martiat, Philippe, Sales, François, Laporte, Marianne, Bruyns, Catherine, Romet-Lemonne, Jean-Loup, Abastado, Jean-Pierre, Lehmann, Frédéric, and Velu, Thierry

Published
2006
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13. Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies

Author

Preillon, Julie, primary, Cuende, Julia, additional, Rabolli, Virginie, additional, Garnero, Lucile, additional, Mercier, Marjorie, additional, Wald, Noémie, additional, Pappalardo, Angela, additional, Denies, Sofie, additional, Jamart, Diane, additional, Michaux, Anne-Catherine, additional, Pirson, Romain, additional, Pitard, Vincent, additional, Bagot, Martine, additional, Prasad, Shruthi, additional, Houthuys, Erica, additional, Brouwer, Margreet, additional, Marillier, Reece, additional, Lambolez, Florence, additional, Marchante, Joäo R., additional, Nyawouame, Florence, additional, Carter, Mathew J., additional, Baron-Bodo, Véronique, additional, Marie-Cardine, Anne, additional, Cragg, Mark, additional, Déchanet-Merville, Julie, additional, Driessens, Gregory, additional, and Hoofd, Catherine, additional

Published
2021
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14. Effector and regulatory dendritic cells display distinct patterns of miRNA expression

Author

Lombardi, Vincent, Luce, Sonia, Moussu, Hélène, Morizur, Lise, Gueguen, Claire, Neukirch, Catherine, Chollet‐Martin, Sylvie, Mascarell, Laurent, Aubier, Michel, Baron‐Bodo, Véronique, and Moingeon, Philippe

Subjects
MicroRNAs, Th2 Cells, Gene Expression Regulation, Humans, Cell Differentiation, Dendritic Cells, Th1 Cells, Rhinitis, Allergic, Allergic rhinitis, Original Research, miRNA, Conjunctivitis, Allergic
Abstract

Introduction MicroRNAs (miRNAs) contribute to the regulation of dendritic cell (DC) polarization, thereby influencing the balance of adaptive immune responses. Herein, we studied the expression of miRNAs in polarized DCs and analyzed whether expression of these miRNAs could be associated with allergic rhinitis and allergen immunotherapy (AIT) outcome. Method Using specific culture conditions, we differentiated immature human monocyte‐derived DCs into DC1, DC2, and DCreg subsets (supporting the differentiation of TH1, TH2 or regulatory T cells, respectively). Profiling of miRNA expression was performed in these DC subpopulations using microarrays. Levels of miRNAs specific for polarized DCs were then evaluated in a cohort of 58 patients with allergic rhinitis and 25 non‐allergic controls, as well as in samples from 30 subjects treated with sublingual grass pollen tablets or placebo for four months. Results We successfully identified 16 miRNAs differentially regulated between immature DCs, DC1, DC2, and DCreg cells. In allergic rhinoconjunctivitis patients, the expression of two of those miRNAs (miR‐132 and miR‐155), was down‐regulated compared to non‐allergic individuals. However, the levels of these miRNAs were not significantly modified following four months of grass pollen immunotherapy. Conclusions Studying polarized DCs and clinical samples from subjects with or without allergic rhinoconjunctivitis, we demonstrated that the expression of two miRNAs linked to effector DCs (i.e., DC1 and/or DC2 cells), was reduced in the blood of patients with allergic rhinoconjunctivitis. Nevertheless, these miRNAs did not represent relevant biomarkers to predict or follow‐up AIT efficacy.

Published
2017

18. CCR 10 + ILC 2s with ILC 1‐like properties exhibit a protective function in severe allergic asthma

Author

Beuraud, Chloé, primary, Lombardi, Vincent, additional, Luce, Sonia, additional, Horiot, Stéphane, additional, Naline, Emmanuel, additional, Neukirch, Catherine, additional, Airouche, Sabi, additional, Perchet, Thibaut, additional, Golub, Rachel, additional, Devillier, Philippe, additional, Chollet‐Martin, Sylvie, additional, Baron‐Bodo, Véronique, additional, Nony, Emmanuel, additional, Aubier, Michel, additional, Mascarell, Laurent, additional, and Moingeon, Philippe, additional

Published
2018
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22. IL‐10 mRNA levels in whole blood cells correlate with house dust mite allergen immunotherapy efficacy.

Author

Guéguen, Claire, Luce, Sonia, Lombardi, Vincent, Baron‐Bodo, Véronique, Moingeon, Philippe, and Mascarell, Laurent

Subjects
HOUSE dust mites, BLOOD cells, MESSENGER RNA, ALLERGENS, ALLERGIC conjunctivitis, ALLERGIC rhinitis
Abstract

IL-10 mRNA levels in whole blood cells correlate with house dust mite allergen immunotherapy efficacy With this need in mind, we undertook a gene expression analysis on whole blood cells obtained from a sub-group of 152 Japanese patients included in a double-blind placebo-controlled clinical HDM AIT study (S-524101)[2] to search for predictive biomarker candidates. Confirmation that I IL-10 i gene expression levels in whole blood represent a candidate biomarker for predicting HDM AIT efficacy is currently ongoing in larger cohorts of patients receiving HDM AIT. [Extracted from the article]

Published
2019
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23. CCR10+ILC2s with ILC1‐like properties exhibit a protective function in severe allergic asthma.

Author

Beuraud, Chloé, Lombardi, Vincent, Luce, Sonia, Horiot, Stéphane, Naline, Emmanuel, Neukirch, Catherine, Airouche, Sabi, Perchet, Thibaut, Golub, Rachel, Devillier, Philippe, Chollet‐Martin, Sylvie, Baron‐Bodo, Véronique, Nony, Emmanuel, Aubier, Michel, Mascarell, Laurent, and Moingeon, Philippe

Subjects
ASTHMA, FLOW cytometry, LUNGS, ASTHMATICS
Abstract

Background: We previously showed that patients with severe allergic asthma have high numbers of circulating ILC2s expressing CCR10. Method: Herein, CCR10+ILC2s were further analyzed in the blood of healthy individuals or patients with allergic and non−allergic asthma. Characteristics of human CCR10+ and CCR10−ILC2s were assessed by flow cytometry as well as single‐cell multiplex RT‐qPCR. The role of CCR10+ILC2s in asthma pathophysiology was studied in allergen‐treated mice. Results: When compared to healthy controls, CCR10+ILC2s are enriched in the blood of both allergic and non‐allergic severe asthmatic patients, and these cells are recruited to the lungs. Plasma concentrations of the CCR10 ligand CCL27 are significantly increased in severe asthmatics when compared to non‐asthmatic patients. CCR10+ILC2s secrete little TH2 cytokines, but exhibit ILC1‐like properties, including a capacity to produce IFN‐γ. Also, single‐cell analysis reveals that the CCR10+ILC2 subset is enriched in cells expressing amphiregulin. CCR10+ILC2 depletion, as well as blocking of IFN‐γ activity, exacerbates airway hyperreactivity in allergen‐challenged mice, providing evidence for a protective role of these cells in allergic inflammation. Conclusions: Frequencies of circulating CCR10+ILC2s and CCL27 plasma concentrations represent candidate markers of asthma severity. The characterization of CCR10+ILC2s in human samples and in mouse asthma models suggests that these cells downregulate allergic inflammation through IFN‐γ production. [ABSTRACT FROM AUTHOR]

Published
2019
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24. 6th International Symposium on Molecular Allergology (ISMA)

Author

Hilger, Christiane, primary, Swiontek, Kyra, additional, Fischer, Jörg, additional, Hentges, François, additional, Lehners, Christiane, additional, Morisset, Martine, additional, Eberlein, Bernadette, additional, Biedermann, Tilo, additional, Ollert, Markus, additional, Wildner, Sabrina, additional, Stemeseder, Teresa, additional, Freier, Regina, additional, Briza, Peter, additional, Lang, Roland, additional, Batanero, Eva, additional, Villalba, Mayte, additional, Lidholm, Jonas, additional, Hawranek, Thomas, additional, Ferreira, Fatima, additional, Brandstetter, Hans, additional, Gadermaier, Gabriele, additional, Moingeon, Philippe, additional, Groeme, Rachel, additional, Bouley, Julien, additional, Bordas, Véronique, additional, Le Mignon, Maxime, additional, Bussières, Laetitia, additional, Lautrette, Aurélie, additional, Mascarell, Laurent, additional, Lombardi, Vincent, additional, Baron-Bodo, Véronique, additional, Chabre, Henri, additional, Batard, Thierry, additional, Nony, Emmanuel, additional, De Amicis, Karine Marafigo, additional, Watanabe, Alexandra Sayuri, additional, Figo, Daniele Danella, additional, Dos Santos-Pinto, José Roberto Aparecido, additional, Palma, Mario Sergio, additional, Castro, Fabio Fernandes Morato, additional, Kalil, Jorge, additional, Wohlschlager, Therese, additional, Ferreira-Briza, Fatima, additional, Santos, Keity Souza, additional, Faber, Margaretha, additional, Van Gasse, Athina, additional, Sabato, Vito, additional, Hagendorens, Margo M., additional, Bridts, Chris H., additional, De Clerck, Luc S., additional, Perales, Araceli Diaz, additional, Ebo, Didier, additional, Zavadakova, Petra, additional, Buchwalder, Aurélie, additional, Rebeaud, Fabien, additional, Märki, Iwan, additional, Gepp, Barbara, additional, Lengger, Nina, additional, Möbs, Christian, additional, Pfützner, Wolfgang, additional, Radauer, Christian, additional, Bohle, Barbara, additional, Galvao, Clovis Eduardo, additional, Santos-Pinto, Jose Roberto Aparecido, additional, Schwager, Christian, additional, Kull, Skadi, additional, Schocker, Frauke, additional, Behrends, Jochen, additional, Becker, Wolf-Meinhard, additional, Jappe, Uta, additional, Mastrorilli, Carla, additional, Tripodi, Salvatore, additional, Caffarelli, Carlo, additional, Asero, Riccardo, additional, Dondi, Arianna, additional, Ricci, Giampaolo, additional, Dascola, Carlotta Povesi, additional, Calamelli, Elisabetta, additional, Di Rienzo Businco, Andrea, additional, Bianchi, Annamaria, additional, Frediani, Tullio, additional, Verga, Carmen, additional, Iacono, Iride Dello, additional, Peroni, Diego, additional, Pingitore, Giuseppe, additional, Bernardini, Roberto, additional, Matricardi, Paolo Maria, additional, Hofer, Heidi, additional, Asam, Claudia, additional, Hauser, Michael, additional, Himly, Martin, additional, Ebner, Christof, additional, Lemoine, Pierrick, additional, Jain, Karine, additional, Abiteboul, Kathy, additional, Arvidsson, Monica, additional, Rak, Sabina, additional, Mota, Inês, additional, Garcia, Filipe Benito, additional, Gaspar, Angela, additional, Arêde, Cristina, additional, Piedade, Susana, additional, Sampaio, Graça, additional, Pires, Graça, additional, Borrego, Luís Miguel, additional, Santa-Marta, Cristina, additional, Morais-Almeida, Mário, additional, Popescu, Florin-Dan, additional, Vieru, Mariana, additional, Secureanu, Florin-Adrian, additional, Fernandes, Rosa Anita Rodrigues, additional, Carrapatoso, Isabel, additional, Gomes, Raquel, additional, Pereira, Celso, additional, Todo-Bom, Ana, additional, De Basoa, María Cecilia Martín Fernández, additional, Regio, Javier Barrios, additional, De Castro Cordova, Juan, additional, Ferreiro, Antón Fernández, additional, Tsilochristou, Olympia, additional, Perna, Serena, additional, Schwarz, Alina, additional, Rohrbach, Alexander, additional, Cappella, Antonio, additional, Hatzler, Laura, additional, Bauer, Carl-Peter, additional, Hoffmann, Ute, additional, Forster, Johannes, additional, Zepp, Fred, additional, Schuster, Antje, additional, D’amelio, Raffael, additional, Wahn, Ulrich, additional, Keil, Thomas, additional, Lau, Susanne, additional, Apoil, Pol André, additional, Mailhol, Claire, additional, Broué-Chabbert, Anne, additional, Juchet, Agnès, additional, Didier, Alain, additional, Carrer, Elodie, additional, Lanot, Thomas, additional, Blancher, Antoine, additional, Kurtaj, Almedina, additional, Hillebrand, Christoph, additional, Fichtinger, Gerda, additional, Danzer, Martin, additional, Gabriel, Christian, additional, Thalhamer, Theresa, additional, Scheiblhofer, Sandra, additional, Thalhamer, Josef, additional, Weiss, Richard, additional, Wolf, Martin, additional, Pichler, Ulrike, additional, Twaroch, Teresa, additional, Yokoi, Hidenori, additional, Takai, Toshiro, additional, Didierlaurent, Alain, additional, Mari, Adriano, additional, Behrendt, Heidrun, additional, Neubauer, Angela, additional, Stolz, Frank, additional, Ferreira, Fátima, additional, Wallner, Michael, additional, Carvalho, Sara, additional, Lourenço, Tatiana, additional, Cosme, Joana, additional, Duarte, Fátima Cabral, additional, Santos, Amélia Spínola, additional, Costa, Ana Célia, additional, Barbosa, Manuel Pereira, additional, Klinglmayr, Eva, additional, Schweidler, Bettina, additional, Lueftenegger, Lisa, additional, Moser, Stephanie, additional, Doppler, Patrick, additional, Oostingh, Gertie J., additional, Bathke, Arne, additional, Zumbach, Joerg, additional, Panzner, Petr, additional, Vachova, Martina, additional, Vlas, Tomas, additional, Maly, Marek, additional, Posa, Daniela, additional, Hofmaier, Stephanie, additional, Stock, Philippe, additional, Grabenhenrich, Linus, additional, Chen, Kuan-Wei, additional, Resch, Yvonne, additional, Vrtala, Susanne, additional, Valenta, Rudolf, additional, Abramidze, Tamar, additional, Lomidze, Nino, additional, Gotua, Maia, additional, Dapkeviciute, Austeja, additional, Einikyte, Ruta, additional, Norkuniene, Jolita, additional, Skrickiene, Laima, additional, Miskiniene, Asta, additional, Kvedariene, Violeta, additional, Schiener, Maximilian, additional, Moreno-Aguilar, Carmen, additional, Pietsch, Gunilla, additional, Intyre, Mareike Mc, additional, Schwarze, Lea, additional, Rußkamp, Dennis, additional, Spillner, Edzard, additional, Darsow, Ulf, additional, Schmidt-Weber, Carsten, additional, Blank, Simon, additional, Longé, Cyril, additional, Brazdova, Andrea, additional, Brunet, Jean-Louis, additional, Schwartz, Claire, additional, Girodet, Bruno, additional, Lavaud, François, additional, Birnbaum, Joelle, additional, Thi, Nhân Pham, additional, Duchateau, Magalie, additional, Chamot-Rooke, Julia, additional, Guilloux, Laurence, additional, Selva, Marie-Ange, additional, Couderc, Rémy, additional, Sénéchal, Hélène, additional, Sutra, Jean-Pierre, additional, Poncet, Pascal, additional, Augustin, Steffen, additional, Pump, Linda, additional, Wald, Martin, additional, Eichhorn, Thomas, additional, Fischer, Frank, additional, Willers, Christoph, additional, Miehe, Michaela, additional, Plum, Melanie, additional, Wolf, Sara, additional, Jabs, Frederic, additional, Raiber, Tim, additional, Bantleon, Frank, additional, Seismann, Henning, additional, Jakob, Thilo, additional, Apostolovic, Danijela, additional, Tran, Anh Thu, additional, Sanchez-Vidaurre, Sara, additional, Velickovic, Tanja Cirkovic, additional, Starkhammar, Maria, additional, Hamsten, Carl, additional, Van Hage, Marianne, additional, Dubiela, Pawel, additional, Humeniuk, Piotr, additional, Pfeifer, Sabine, additional, Bublin, Merima, additional, Borowski, Tomasz, additional, Hoffmann-Sommergruber, Karin, additional, Verschuren, Martie C. M., additional, Bastiaan-Net, Shanna, additional, Depoortere, Defien, additional, Foetisch, Kay, additional, Scheurer, Stephan, additional, Wichers, Harry J, additional, Noij, Theo, additional, Van Uden, Nikki M.E., additional, Vandenberghe, Karel, additional, Wichers, Harry J., additional, Noij, Theo H. M., additional, Roulias, Anargyros, additional, Parigiani, Maria Alejandra, additional, Ahammer, Linda, additional, Grutsch, Sarina, additional, Tollinger, Martin, additional, Moya, Raquel, additional, López-Matas, Mª Angeles, additional, Reyes, Raquel, additional, Carnés, Jerónimo, additional, Larré, Colette, additional, Rogniaux, Hélène, additional, Lupi, Roberta, additional, Denery-Papini, Sandra, additional, Pablos, Isabel Maria, additional, Eichhorn, Stephanie, additional, Machado, Yoan, additional, Park, Jung-Won, additional, Arora, Naveen, additional, Vieths, Stefan, additional, Tanaka, Charlene, additional, Pineau, Florence, additional, Drouet, Martine, additional, Beaudouin, Etienne, additional, Altenbach, Susan, additional, Mameri, Hamza, additional, Brossard, Chantal, additional, Gaudin, Jean Charles, additional, Moneret-Vautrin, Denise Anne, additional, Paty, Evelyne, additional, Tranquet, Olivier, additional, Masci, Stefania, additional, Moneret-Vautrin, Denise-Anne, additional, Petersen, Arnd, additional, Böttger, Marisa, additional, Rennert, Sandra, additional, Krause, Susanne, additional, Ernst, Martin, additional, Gutsmann, Thomas, additional, Bauer, Johann, additional, Lindner, Buko, additional, Koppelman, Stef, additional, Jayasena, Shyamali, additional, Luykx, Dion, additional, Schepens, Erik, additional, De Jong, Govardus, additional, Isleib, Tom, additional, Nordlee, Julie, additional, Baumert, Joe, additional, Taylor, Steve, additional, Maleki, Soheila, additional, Palladino, Chiara, additional, Sirvent, Sofía, additional, Angelina, Alba, additional, Eiwegger, Thomas, additional, Palomares, Oscar, additional, Breiteneder, Heimo, additional, Claude, Mathilde, additional, Bouchaud, Grégory, additional, Bodinier, Marie, additional, Korte, Robin, additional, Bräcker, Julia, additional, Brockmeyer, Jens, additional, Satoh, Rie, additional, Teshima, Reiko, additional, Tscheppe, Angelika, additional, Palmberger, Dieter, additional, Grabherr, Reingard, additional, Raith, Marianne, additional, Sonnleitner, Linda, additional, Zach, Doris, additional, Woroszylo, Konrad, additional, Focke-Tejkl, Margit, additional, Wank, Herbert, additional, Graf, Thorsten, additional, Kuehn, Annette, additional, Swoboda, Ines, additional, Huber, Sara, additional, Gay-Crosier, Fabienne, additional, Polak, Dominika, additional, Nagl, Birgit, additional, Kitzmüller, Claudia, additional, Samadi, Nazanin, additional, Geyeregger, Rene, additional, Jahn-Schmid, Beatrice, additional, Gomez, Ariel, additional, Haka, Jaana, additional, Hattara, Liisa, additional, Heikkinen, Marika, additional, Niemi, Merja H, additional, Rouvinen, Juha, additional, Saviranta, Petri, additional, Mattila, Pekka, additional, Takkinen, Kristiina, additional, Laukkanen, Marja-Leena, additional, Pablos, Isabel, additional, Kastner, Bianca, additional, Silar, Mira, additional, Selb, Julij, additional, Kogovsek, Rok, additional, Kosnik, Mitja, additional, Korosec, Peter, additional, Pestana, Leticia, additional, Melo, Alcinda Campos, additional, Mendes, Ana, additional, Pedro, Maria Elisa, additional, Santos, Maria Conceição Pereira, additional, Bienvenu, Françoise, additional, Goursaud, Claire, additional, Garnier, Lorna, additional, Jacquenet, Sandrine, additional, Degaud, Michaël, additional, Viel, Sébastien, additional, Barre, Annick, additional, Rougé, Pierre, additional, Bienvenu, Jacques, additional, Vitte, Joana, additional, Bensalah, Amel, additional, Cleach, Isabelle, additional, Mousseau, Laurent, additional, Agabriel, Chantal, additional, Liabeuf, Valérie, additional, Birnbaum, Joëlle, additional, Mège, Jean-Louis, additional, Gardner, James, additional, Gandhi, Minal, additional, Kariyawasam, Harsha, additional, Rotiroti, Giuseppina, additional, Regateiro, Frederico, additional, Faria, Emília, additional, Schmid, Johannes Martin, additional, Dahl, Ronald, additional, Hoffmann, Hans Juergen, additional, Pestana, Letícia, additional, Silva, Diana, additional, Vieira, Teresa, additional, Pereira, Ana Maria, additional, Moreira, André, additional, Delgado, Luís, additional, Prates, Sara, additional, Alves, Cátia, additional, Finelli, Elena, additional, Pinto, Paula Leiria, additional, Cardoso, Bárbara Kong, additional, Cruz, Cíntia, additional, Semedo, Filipa, additional, Tomaz, Elza, additional, Inácio, Filipe, additional, Maity, Santanu, additional, Baricevic-Jones, Ivona, additional, Marsh, Justin T., additional, Johnson, Phil E., additional, Balasundaram, Anuradha, additional, Hope, Anya-May, additional, Taekema, Aafke, additional, Simpson, Angela, additional, Semic-Jusufagic, Aida, additional, Clare Mills, E. N., additional, Nelly, Gourdon Dubois, additional, Laetitia, Sellam, additional, Bruno, Pereira, additional, Elodie, Michaud, additional, Khaled, Messaoudi, additional, Bertrand, Evrard, additional, Jean-Luc, Fauquert, additional, Goodman, Richard E., additional, Plata, Elena Rodríguez, additional, Amaral, Luis, additional, Bartolomé, Borja, additional, Coimbra, Alice, additional, Placido, Jose L, additional, Ganea, Carmen Saviana, additional, Costello, Carol Ann, additional, Sorensen, Martin, additional, Mills, Clare, additional, Rogers, Adrian, additional, Otherhals, Aage, additional, Kalic, Tanja, additional, Ellinger, Isabella, additional, Waltl, Eva, additional, Niederberger-Leppin, Verena, additional, Szczepankiewicz, Dawid, additional, Pruszynska-Oszmalek, Ewa, additional, Skrzypski, Marek, additional, Nowak, Krzysztof W., additional, Szczepankiewicz, Aleksandra, additional, Jang, Gwang-Cheon, additional, Markovic, Iva, additional, Borowski, Andreas, additional, Vetter, Tina, additional, Wohlmann, Andreas, additional, Kuepper, Michael, additional, Friedrich, Karlheinz, additional, Gracia, Ibon Eguiluz, additional, Bosco, Anthony, additional, Dollner, Ralph, additional, Melum, Guro Reinholt, additional, Jones, Anya C, additional, Lexberg, Maria, additional, Holt, Patrick G, additional, Bækkevold, Espen Sønderaal, additional, Jahnsen, Frode Lars, additional, Sobkowiak, Paulina, additional, Rachel, Marta, additional, Narozna, Beata, additional, Jenerowicz, Dorota, additional, Swiatowy, Witold, additional, Breborowicz, Anna, additional, Nestelbacher, Reinhard, additional, and Fukui, Hiroyuki, additional

Published
2016
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27. Identification Of The Cysteine Protease Amb a x As A Novel Major Allergen From Short Ragweed Pollen (Ambrosia artemisiifolia)

Author

Moingeon, Philippe, primary, Bouley, Julien, additional, Le Mignon, Maxime, additional, Baron-Bodo, Véronique, additional, Bordas, Véronique, additional, Bussières, Laetitia, additional, Couret, Marie-Noëlle, additional, Lautrette, Aurélie, additional, Batard, Thierry, additional, Groeme, Rachel, additional, Chabre, Henri, additional, and Nony, Emmanuel, additional

Published
2014
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28. Molecular Differences in Major and Minor Allergens From US Grass Species Support the Association of Several Pollens for Specific Immunotherapy

Author

Batard, Thierry, primary, Chabre, Henri, additional, Baron-Bodo, Véronique, additional, Nony, Emmanuel, additional, Lautrette, Aurélie, additional, Couret, Marie-Noëlle, additional, Lemoine, Pierrick, additional, Berjont, Nathalie, additional, Hrabina, Maud, additional, Jain, Karine, additional, and Moingeon, Philippe, additional

Published
2013
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29. Recombinant Fusion Proteins Assembling Der p 1 and Der p 2 Allergens from Dermatophagoides pteronyssinus

Author

Bussières, Laetitia, primary, Bordas-Le Floch, Véronique, additional, Bulder, Ingrid, additional, Chabre, Henri, additional, Nony, Emmanuel, additional, Lautrette, Aurélie, additional, Berrouet, Christelle, additional, Nguefeu, Yvette, additional, Horiot, Stéphane, additional, Baron-Bodo, Véronique, additional, Van Overtvelt, Laurence, additional, De Conti, Anne Marie, additional, Schlegel, Anne, additional, Maguet, Nicolas, additional, Mouz, Nicolas, additional, Lemoine, Pierrick, additional, Batard, Thierry, additional, and Moingeon, Philippe, additional

Published
2010
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31. Vaccination of melanoma patients using dendritic cells loaded with an allogeneic tumor cell lysate

Author

Salcedo, Margarita, primary, Bercovici, Nadège, additional, Taylor, Rachel, additional, Vereecken, Pierre, additional, Massicard, Séverine, additional, Duriau, Dominique, additional, Vernel-Pauillac, Frédérique, additional, Boyer, Aurélie, additional, Baron-Bodo, Véronique, additional, Mallard, Eric, additional, Bartholeyns, Jacques, additional, Goxe, Béatrice, additional, Latour, Nathalie, additional, Leroy, Sophie, additional, Prigent, Didier, additional, Martiat, Philippe, additional, Sales, François, additional, Laporte, Marianne, additional, Bruyns, Catherine, additional, Romet-Lemonne, Jean-Loup, additional, Abastado, Jean-Pierre, additional, Lehmann, Frédéric, additional, and Velu, Thierry, additional

Published
2005
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32. Expression and Characterization of Natural-Like Recombinant Der p 2 for Sublingual Immunotherapy.

Author

Bordas-Le Floch, Véronique, Bussières, Laetitia, Airouche, Sabi, Lautrette, Aurélie, Bouley, Julien, Berjont, Nathalie, Horiot, Stéphane, Huet, Axelle, Jain, Karine, Lemoine, Pierrick, Chabre, Henri, Batard, Thierry, Mascarell, Laurent, Baron-Bodo, Véronique, Tourdot, Sophie, Nony, Emmanuel, and Moingeon, Philippe

Subjects
GENE expression, RECOMBINANT proteins, SUBLINGUAL gland, ALLERGIES, IMMUNOTHERAPY, ALLERGENS, PICHIA pastoris, YEAST extract, VACCINATION
Abstract

Background: Recombinant allergens with a native conformation represent an alternative to natural extracts for immunotherapy and diagnostic purposes. Methods: We produced the Der p 2 mite allergen in Pichia pastoris and Escherichia coli. After purification by cation exchange chromatography, recombinant molecules were compared to their natural counterpart based upon structural (disulfide bonds, secondary structure, thermal stability) and immunological properties (antibody reactivity, basophil and T cell activation, tolerance induction in a murine sublingual immunotherapy model). Results: The Der p 2.0101 isoform was confirmed to be prevalent in Dermatophagoides pteronyssinus extracts. It was then produced as a secreted molecule in P. pastoris or refolded from E. coli inclusion bodies. The yeast-expressed rDer p 2 molecule exhibits a natural-like disulfide bridge distribution and secondary structure, whereas the E. coli-derived rDer p 2 presents some heterogeneity in cysteine bonds and a lower stability following thermal stress. The two recombinant as well as natural Der p 2 molecules exhibit comparable IgE recognition and activate basophil and CD4+ T cells. Sublingual immunotherapy of nDer p 2- sensitized mice using either one of the rDer p 2 molecules efficiently decreases airway hyperresponsiveness as well as Th2 responses. Conclusions: Natural and recombinant Der p 2 molecules produced in P. pastoris and E. coli exhibit comparable immunological properties despite distinct structural features. Natural-like cysteine pairing is a critical parameter to identify stable, well-folded and homogenous proteins appropriate for immunotherapy and diagnostic purposes. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2012
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