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18 results on '"Barták, Barbara K."'

3. Patterns of Somatic Variants in Colorectal Adenoma and Carcinoma Tissue and Matched Plasma Samples from the Hungarian Oncogenome Program

Author

Kalmár, Alexandra, primary, Galamb, Orsolya, additional, Szabó, Gitta, additional, Pipek, Orsolya, additional, Medgyes-Horváth, Anna, additional, Barták, Barbara K., additional, Nagy, Zsófia B., additional, Szigeti, Krisztina A., additional, Zsigrai, Sára, additional, Csabai, István, additional, Igaz, Péter, additional, Molnár, Béla, additional, and Takács, István, additional

Published
2023
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4. Methodological and Biological Factors Influencing Global DNA Methylation Results Measured by LINE-1 Pyrosequencing Assay in Colorectal Tissue and Liquid Biopsy Samples

Author

Szigeti, Krisztina A, primary, Barták, Barbara K, additional, Nagy, Zsófia B, additional, Zsigrai, Sára, additional, Papp, Márton, additional, Márkus, Eszter, additional, Igaz, Peter, additional, Takács, István, additional, Molnár, Béla, additional, and Kalmár, Alexandra, additional

Published
2022
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6. Folic Acid Treatment Directly Influences the Genetic and Epigenetic Regulation along with the Associated Cellular Maintenance Processes of HT-29 and SW480 Colorectal Cancer Cell Lines

Author

Zsigrai, Sára, primary, Kalmár, Alexandra, additional, Barták, Barbara K., additional, Nagy, Zsófia B., additional, Szigeti, Krisztina A., additional, Valcz, Gábor, additional, Kothalawala, William, additional, Dankó, Titanilla, additional, Sebestyén, Anna, additional, Barna, Gábor, additional, Pipek, Orsolya, additional, Csabai, István, additional, Tulassay, Zsolt, additional, Igaz, Péter, additional, Takács, István, additional, and Molnár, Béla, additional

Published
2022
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7. Additional file 1 of Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content

Author

Szigeti, Krisztina A., Kalmár, Alexandra, Galamb, Orsolya, Valcz, Gábor, Barták, Barbara K., Nagy, Zsófia B., Zsigrai, Sára, Felletár, Ildikó, V. Patai, Árpád, Micsik, Tamás, Papp, Márton, Márkus, Eszter, Tulassay, Zsolt, Igaz, Peter, Takács, István, and Molnár, Béla

Abstract

Additional file 1. Summary of LINE-1 methylation levels, clinicopathological and demographic data of the investigated patients

Published
2022
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8. Abstract 164: Alteration of DNA methylation, DNA repair and epithelial-mesenchymal transition in colorectal cancer cell lines by S-adenosylmethionine treatment

Author

Zsigrai, Sára, primary, Kalmár, Alexandra, additional, Szigeti, Krisztina Andrea, additional, Nagy, Zsófia Brigitta, additional, Barták, Barbara K., additional, Valcz, Gábor, additional, Galamb, Orsolya, additional, Dankó, Titanilla, additional, Tulassay, Zsolt, additional, Igaz, Péter, additional, and Molnár, Béla, additional

Published
2020
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9. Abstract 155: Global DNA hypomethylation can be caused by decreased methyl-donor content in tissue and liquid biopsy samples in colorectal cancer progression

Author

Szigeti, Krisztina A., primary, Galamb, Orsolya, additional, Kalmár, Alexandra, additional, Valcz, Gábor, additional, Zsigrai, Sára, additional, Barták, Barbara K., additional, Nagy, Zsófia B., additional, Tulassay, Zsolt, additional, Igaz, Péter, additional, and Molnár, Béla, additional

Published
2020
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10. S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression

Author

Zsigrai, Sára, primary, Kalmár, Alexandra, additional, Nagy, Zsófia B., additional, Barták, Barbara K., additional, Valcz, Gábor, additional, Szigeti, Krisztina A., additional, Galamb, Orsolya, additional, Dankó, Titanilla, additional, Sebestyén, Anna, additional, Barna, Gábor, additional, Szabó, Vanessza, additional, Pipek, Orsolya, additional, Medgyes-Horváth, Anna, additional, Csabai, István, additional, Tulassay, Zsolt, additional, Igaz, Péter, additional, Takács, István, additional, and Molnár, Béla, additional

Published
2020
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14. Sa1901 Bacterial DNA and Methylated Host DNA Sequences in Plasma Samples of Healthy and Colorectal Cancer Patients: A Whole-Metagenome Analysis

Author

Barták, Barbara K., primary, Spisak, Sandor, additional, Ittzés, Péter, additional, Bodor, András, additional, Kondor, Dániel, additional, Vattay, Gábor, additional, Nagy, Zsofia B., additional, Kalmár, Alexandra, additional, Tulassay, Zsolt, additional, Csabai, István, additional, and Molnár, Béla, additional

Published
2014
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15. Complete genes may pass from food to human blood

Author

Spisák, Sándor, Solymosi, Norbert, Ittzés, Péter, Bodor, András, Kondor, Dániel, Vattay, Gábor, Barták, Barbara K, Sipos, Ferenc, Galamb, Orsolya, Tulassay, Zsolt, Szállási, Zoltán, Rasmussen, Simon, Sicheritz-Ponten, Thomas, Brunak, Søren, Molnár, Béla, Csabai, István, Spisák, Sándor, Solymosi, Norbert, Ittzés, Péter, Bodor, András, Kondor, Dániel, Vattay, Gábor, Barták, Barbara K, Sipos, Ferenc, Galamb, Orsolya, Tulassay, Zsolt, Szállási, Zoltán, Rasmussen, Simon, Sicheritz-Ponten, Thomas, Brunak, Søren, Molnár, Béla, and Csabai, István

Abstract

Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. The plant DNA concentration shows a surprisingly precise log-normal distribution in the plasma samples while non-plasma (cord blood) control sample was found to be free of plant DNA.

Published
2013

16. Complete Genes May Pass from Food to Human Blood

Author

Spisák, Sándor, primary, Solymosi, Norbert, additional, Ittzés, Péter, additional, Bodor, András, additional, Kondor, Dániel, additional, Vattay, Gábor, additional, Barták, Barbara K., additional, Sipos, Ferenc, additional, Galamb, Orsolya, additional, Tulassay, Zsolt, additional, Szállási, Zoltán, additional, Rasmussen, Simon, additional, Sicheritz-Ponten, Thomas, additional, Brunak, Søren, additional, Molnár, Béla, additional, and Csabai, István, additional

Published
2013
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17. Can long-read sequencing tackle the barriers, which the next-generation could not? A review.

Author

Szakállas N, Barták BK, Valcz G, Nagy ZB, Takács I, and Molnár B

Subjects
Humans, Computational Biology methods, Genomics methods, Sequence Analysis, DNA methods, High-Throughput Nucleotide Sequencing methods
Abstract

The large-scale heterogeneity of genetic diseases necessitated the deeper examination of nucleotide sequence alterations enhancing the discovery of new targeted drug attack points. The appearance of new sequencing techniques was essential to get more interpretable genomic data. In contrast to the previous short-reads, longer lengths can provide a better insight into the potential health threatening genetic abnormalities. Long-reads offer more accurate variant identification and genome assembly methods, indicating advances in nucleotide deflect-related studies. In this review, we introduce the historical background of sequencing technologies and show their benefits and limits, as well. Furthermore, we highlight the differences between short- and long-read approaches, including their unique advances and difficulties in methodologies and evaluation. Additionally, we provide a detailed description of the corresponding bioinformatics and the current applications., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Szakállas, Barták, Valcz, Nagy, Takács and Molnár.)

Published
2024
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18. A Detailed Overview About the Single-Cell Analyses of Solid Tumors Focusing on Colorectal Cancer.

Author

Kothalawala WJ, Barták BK, Nagy ZB, Zsigrai S, Szigeti KA, Valcz G, Takács I, Kalmár A, and Molnár B

Subjects
Humans, Tumor Microenvironment, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology, Single-Cell Analysis
Abstract

In recent years, the evolution of the molecular biological technical background led to the widespread application of single-cell sequencing, a versatile tool particularly useful in the investigation of tumor heterogeneity. Even 10 years ago the comprehensive characterization of colorectal cancers by The Cancer Genome Atlas was based on measurements of bulk samples. Nowadays, with single-cell approaches, tumor heterogeneity, the tumor microenvironment, and the interplay between tumor cells and their surroundings can be described in unprecedented detail. In this review article we aimed to emphasize the importance of single-cell analyses by presenting tumor heterogeneity and the limitations of conventional investigational approaches, followed by an overview of the whole single-cell analytic workflow from sample isolation to amplification, sequencing and bioinformatic analysis and a review of recent literature regarding the single-cell analysis of colorectal cancers., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Kothalawala, Barták, Nagy, Zsigrai, Szigeti, Valcz, Takács, Kalmár and Molnár.)

Published
2022
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