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7. 2021 Asia-Pacific Graves’ Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves’ Disease

Author

Parameswaran, Rajeev, de Jong, Mechteld Christine, Kit, James Lee Wai, Sek, Kathleen, Nam, Tran Quang, Thang, Tran Viet, Khue, Nguyen Thy, Aye, Than Than, Tun, Phone Myint, Cole, Timothy, Miller, Julie A., Villa, Michael, Khiewvan, Benjapa, Sirinvaravong, Sirinart, Sin, Yong Lit, Muhammad, Rohaizak, Jap, Tjin Shing, Agrawal, Amit, Rajput, Rajesh, Fernando, Ranil, Sumanatilleke, Manilka, Suastika, Ketut, Shong, Young Kee, Lang, Brian, Bartalena, Luigi, and Yang, Samantha Peiling

Published
2023
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19. Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO): a randomised, observer-masked, multicentre trial

Author

Ayvaz, Göksun, Baldeschi, Lelio, Boborides, Kostas, Boschi, Antonella, Brix, Thomas H, Clarke, Lucy, Dayan, Colin, Daumerie, Chantal, Dickinson, A Jane, Fichter, Nicole, Hegedüs, Laszlo, Konuk, Onur, Krassas, Gerassimos E, Lane, Carol, Lazarus, John, Morris, Dan S, Mourits, Maarten., Nardi, Marco, Neoh, Chris, Orgiazzi, Jacques, Pearce, Simon H S, von Arx, Georg, Zarkovic, Milos, Kahaly, George J, Riedl, Michaela, König, Jochem, Pitz, Susanne, Ponto, Katharina, Diana, Tanja, Kampmann, Elena, Kolbe, Elisa, Eckstein, Anja, Moeller, Lars C, Führer, Dagmar, Salvi, Mario, Curro, Nicola, Campi, Irene, Covelli, Danila, Leo, Marenza, Marinò, Michele, Menconi, Francesca, Marcocci, Claudio, Bartalena, Luigi, Perros, Petros, and Wiersinga, Wilmar M

Published
2018
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27. Immunomodulatory role of vitamin D and selenium supplementation in newly diagnosed Graves’ disease patients during methimazole treatment

Author

Gallo, Daniela, primary, Bruno, Antonino, additional, Gallazzi, Matteo, additional, Cattaneo, Simona Antonia Maria, additional, Veronesi, Giovanni, additional, Genoni, Angelo, additional, Tanda, Maria Laura, additional, Bartalena, Luigi, additional, Passi, Alberto, additional, Piantanida, Eliana, additional, and Mortara, Lorenzo, additional

Published
2023
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29. Contributors

Author

Ahmann, Andrew J., Aiello, Lloyd Paul, Akamizu, Takashi, Aleksic, Sandra, Alexander, Erik K., Allen, Rebecca H., Anawalt, Bradley D., Anderson, Mark S., Apovian, Caroline M., Arbeláez, Ana María, Arosemena, Marilyn, Atkinson, Mark A., Auchus, Richard J., Babayev, Elnur, Barker, Jennifer M., Bartalena, Luigi, Bartke, Andrzej, Battelino, Tadej, Berga, Sarah L., Berli, Jens U., Bhadada, Sanjay K., Bhan, Arti, Bhasin, Shalender, Bidlingmaier, Martin, Bilezikian, John P., Binkley, Neil, Black, Dennis M., Boulton, Andrew JM, Brown, Todd T., Brownlee, Michael, Bulun, Serdar E., Bushinsky, David A., Casanueva, Felipe F., Chait, Alan, Chan, Yee-Ming, Christ-Crain, Mirjam, Cohen, Ronald, Dattani, Mehul T., Davis, Susan R., de Herder, Wouter W., de Paula, Francisco J.A., DiVall, Sara A., Dovc, Klemen, El-Khairi, Ranna, Feelders, Richard, Feldman, Eva L., Feldt-Rasmussen, Ulla, Ferrannini, Ele, Ferris, Heather A., Flück Pandey, Christa E., Galderisi, Alfonso, Ghigo, Ezio, Gillard, Pieter, Ginsberg, Henry N., Giustina, Andrea, Goldfine, Allison B., Goltzman, David, Gottlieb, Peter A., Gunst, Jan, Hafida, Samar, Hannema, Sabine E., Hayes, Frances J., Haymart, Megan R., Hickey, Martha, Hirschhorn, Joel, Ho, Ken K.Y., Hofland, Johannes, Hollenberg, Anthony, Huguenin, Annabelle, Jacobs, An, Jee, Youn Hee, Jonklaas, Jacqueline, Kahn, C. Ronald, Kaiser, Ursula, Karsenty, Gerard, Katugampola, Harshini, Kaunitz, Andrew M., Kopp, Peter A., Lamberts, Steven W.J., Lanfranco, Fabio, Lechan, Ronald M., Majithia, Amit R., Mannstadt, Michael, Mari, Andrea, Matsumoto, Alvin M., Matthieu, Chantal, Melmed, Shlomo, Miller, Paul D., Milman, Sofiya, Moeller, Lars C., Naylor, Rochelle N., Newey, Paul J., O’Neill, Brian T., Papadakis, Georgios E., Pattison, David A., Philipson, Louis H., Pitteloud, Nelly, Radovick, Sally, Rao, Ajay D., Rao, Sudhaker D., Rickels, Michael R., Riddle, Matthew C., Rosen, Clifford J., Rosen, Evan D., Rosenthal, Stephen M., Rossing, Peter, Rui, Liangyou, Salama, Mahmoud, Salguero, Maria V., Salvatore, Domenico, Silva, Paolo Sandico, Sattar, Naveed, Schoenmakers, Nadia, Sherr, Jennifer L., Sluss, Patrick M., Stanley, Takara, Strasburger, Christian J., Sun, Jennifer K., Takahashi, Yutaka, Tangpricha, Vin, Thakker, Rajesh V., Thompson, Christopher J., Van den Berghe, Greet, Verbalis, Joseph G., Walch, Abby, Walker, Marcella D., Waters, Thaddeus P., Wiersinga, Wilmar, Wirth, Lori J., Witztum, Joseph L., Woodruff, Teresa K., Young, William F., Jr., and Zeiger, Martha A.

Published
2025
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30. Immunomodulatory role of vitamin D and selenium supplementation in newly diagnosed Graves' disease patients during methimazole treatment

Author

Gallo, Daniela, Bruno, Antonino, Gallazzi, Matteo, Cattaneo, Simona Antonia Maria, Veronesi, Giovanni, Genoni, Angelo, Tanda, Maria Laura, Bartalena, Luigi, Passi, Alberto, Piantanida, Eliana, and Mortara, Lorenzo

Subjects
Graves‘ disease, T regulatory cells (T reg), Endocrinology, Diabetes and Metabolism, natural killer (NK) cell, selenium, vitamin D
Abstract

IntroductionMethimazole (MMI) represents the conventional therapeutic agent for Graves’ disease (GD) hyperthyroidism, but MMI efficacy is limited since it marginally affects the underlying autoimmune process. In a previous study, we randomly assigned 42 newly diagnosed GD patients with insufficient vitamin D (VitD) and selenium (Se) levels to treatment with MMI alone (standard) or combined with selenomethionine and cholecalciferol (intervention) and observed a prompter resolution of hyperthyroidism in the intervention group.MethodsIn the present study, we aimed to explore changes in peripheral T regulatory (Treg) and circulating natural killer (NK) cell frequency, circulating NK cell subset distribution and function, during treatment.ResultsAt baseline, circulating total CD3-CD56+NK cells and CD56bright NK cells were significantly higher in GD patients than in healthy controls (HC) (15.7 ± 9.6% vs 9.9 ± 5.6%, p=0.001; 12.2 ± 10.3% vs 7.3 ± 4.1%, p=0.02, respectively); no differences emerged in Treg cell frequency. Frequencies of total NK cells and CD56bright NK cells expressing the activation marker CD69 were significantly higher in GD patients than in HC, while total NK cells and CD56dim NK cells expressing CD161 (inhibitory receptor) were significantly lower. When co-cultured with the K562 target cell, NK cells from GD patients had a significantly lower degranulation ability compared to HC (pbright NK cells: -6.5%, CI 95% -10.1; -3 vs -0.9%, CI 95% -4.4; 2%, p=0.03). Compared to baseline, CD69+ NK cells significantly decreased, while degranulation ability slightly improved, although no differences emerged between the two treatment groups. Compared to baseline, Treg cell frequency increased exclusively in the intervention group (+1.1%, CI 95% 0.4; 1.7%).DiscussionThis pilot study suggested that VitD and Se supplementation, in GD patients receiving MMI treatment, modulates Treg and NK cell frequency, favoring a more pronounced reduction of NK cells and the increase of Treg cells, compared to MMI alone. Even if further studies are needed, it is possible to speculate that this immunomodulatory action might have facilitated the prompter and better control of hyperthyroidism in the supplemented group observed in the previous study.

Published
2023

31. Goiter in Representational Art

Author

Trimarchi, Francesco, Martino, Enio, and Bartalena, Luigi

Subjects
Goiter-Representational, Art, Iodine,deficiency, Renaissance, Modern Art
Abstract

Goiter, defined as an enlargement of the thyroid gland, has been, since the origin of the human species, one of the most common non-communicable diseases. Because iodine is required for thyroid hormone synthesis, diffuse and/or nodular goiter, resulting from a persistent thyroid stimulation, represents the adaptive response to adverse environmental conditions, namely nutritional iodine deficiency. Endemic goiter, defined on a pure epidemiologic basis (i.e., a condition affecting more than 10% of the general population), was widely present in large parts of Europe and Mediterranean area as the predominant iodine deficiency disorder (IDD)., Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, Vol 110, No 2 (2022)

Published
2022
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40. Real-life Data on the Effect of Medical Therapy for Amiodarone-induced Thyrotoxicosis on CV Events and Hospitalizations.

Author

Cappellani, Daniele, Marconcini, Giulia, Manetti, Luca, Bartalena, Luigi, and Bogazzi, Fausto

Abstract

Context: Patients with amiodarone-induced thyrotoxicosis (AIT) often receive initial therapy for thyrotoxicosis in several different medical settings before admission to a referral center. Objective: This work aimed to determine whether first-line medical therapy (ie, therapies for thyrotoxicosis at first diagnosis of AIT) affects the outcome of AIT patients. Methods: A single-center historical-prospective cohort study was conducted on 313 AIT patients. Clinical and biochemical data were collected at first diagnosis, at a referral center, and during the course of AIT. Primary outcomes were cardiovascular (CV) events and hospitalizations. First-line therapies were considered appropriate when they included glucocorticoids for type 2 AIT and methimazole for type 1 AIT at the approved dose, either alone (optimal medical therapy, OMT) or in combination (right-dose combination therapy, RCT). Other therapies were considered not appropriate, including no therapy. Duration of exposure to thyrotoxicosis was the time from first diagnosis of AIT to its remission. Results: A total of 34.5% patients received appropriate therapies (28.1% OMT, 6.4% RCT), whereas the remaining (65.5%) received inappropriate therapies. CV events and hospitalizations were more frequent in patients who received inappropriate therapies (33.2% vs 4.5%, and 24.9% vs 6.5%, respectively; P<.0001 for both). Appropriate therapies reduced serum thyroid hormone concentrations (P=.018) from first diagnosis to referral, unlike the inappropriate therapies. The duration of exposure to thyrotoxicosis was longer in patients receiving inappropriate therapies and was a risk factor for arrhythmias (hazard ratio [HR] 1.004; P=.0008), major acute CV events (HR 1.004; P= .020), and hospitalizations (HR 1.006; P<.0001). Conclusion: The first medical therapy of AIT influences the exposure time to thyrotoxicosis and the occurrence of CV events and hospitalizations. [ABSTRACT FROM AUTHOR]

Published
2023
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46. 2021 Asia Pacific Graves’ Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves’ Disease

Author

Parameswaran, Rajeev, primary, de Jong, Mechteld C, additional, Kit, James Lee Wai, additional, Sek, Kathleen Sy, additional, Nam, Tran Quang, additional, Thang, Tran Viet, additional, Khue, Nguyen Thy, additional, Aye, Than Than, additional, Tun, Phone Myint, additional, Cole, Timothy, additional, Miller, Julie A, additional, Villa, Michael Lim, additional, Khiewvan, Benjapa, additional, Sirinvaravong, Sirinart, additional, Sin, Yong Li, additional, Muhammad, Rohaizak, additional, Jap, Tjin Shing, additional, Agrawal, Amit, additional, Rajput, Rajesh, additional, Fernando, Ranil, additional, Sumanatilleke, Manilka, additional, Suastika, Ketut, additional, Shong, Young Kee, additional, Lang, Brian, additional, Bartalena, Luigi, additional, and Yang, Samantha Peiling, additional

Published
2022
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47. Add-On Effect of Selenium and Vitamin D Combined Supplementation in Early Control of Graves’ Disease Hyperthyroidism During Methimazole Treatment

Author

Gallo, Daniela, primary, Mortara, Lorenzo, additional, Veronesi, Giovanni, additional, Cattaneo, Simona AM, additional, Genoni, Angelo, additional, Gallazzi, Matteo, additional, Peruzzo, Carlo, additional, Lasalvia, Paolo, additional, Moretto, Paola, additional, Bruno, Antonino, additional, Passi, Alberto, additional, Pini, Andrea, additional, Nauti, Andrea, additional, Lavizzari, Maria Antonietta, additional, Marinò, Michele, additional, Lanzolla, Giulia, additional, Tanda, Maria Laura, additional, Bartalena, Luigi, additional, and Piantanida, Eliana, additional

Published
2022
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