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1. Case report: Anti-CARPVIII autoantibody-associated mixed dementia

Author

Niels Hansen, Bianca Teegen, Sina Hirschel, Jens Wiltfang, Björn H. Schott, Berend Malchow, and Bartels Claudia

Subjects
anti-CARPVIII autoantibody, dementia, psychiatry, autoimmunity, mixed dementia, Psychiatry, RC435-571
Abstract

BackgroundAnti-carbonic anhydrase-related protein VIII (CARPVIII) is reported to be associated with paraneoplastic cerebellar degeneration. Our case extends the spectrum of anti-CARPVIII-associated disease to severe cognitive impairment.MethodsWe present the case of a 75-year-old woman who presented to our Department of Psychiatry and Psychotherapy with a dementia syndrome. The diagnostic approach included magnetic resonance imaging (MRI), cerebrospinal fluid analysis (CSF) analysis involving autoantibody determination, and neuropsychological examination.ResultsNeuropsychological examination revealed severe cognitive impairment meeting the criteria for dementia. MRI showed evidence of moderate cerebral microangiopathy. CSF analysis revealed mild pleocytosis, and serum analysis revealed anti-CARPVIII autoantibodies. Based on the dementia syndrome entailing signs of CNS inflammation such as pleocytosis and the repeated detection of anti-CARPVIII autoantibodies in serum, we diagnosed autoimmune dementia as a component of mixed dementia with additional vascular dementia components.ConclusionOur finding adds severe cognitive impairment to the spectrum of anti-CARPVIII-associated disease. However, detecting anti-CARPVIII antibodies may also be an incidental finding in conjunction with typical mixed dementia. Further studies are needed to evaluate the relevance of these clinical findings.

Published
2023
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2. Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia

Author

Malo Gaubert, Andrea Dell’Orco, Catharina Lange, Antoine Garnier-Crussard, Isabella Zimmermann, Martin Dyrba, Marco Duering, Gabriel Ziegler, Oliver Peters, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Emrah Düzel, Frank Jessen, Miranka Wirth, for the DELCODE study group, Amthauer Holger, Cetindag Arda Can, Cosma Nicoleta Carmen, Diesing Dominik, Ehrlich Marie, Fenski Frederike, Freiesleben Silka Dawn, Fuentes Manuel, Hauser Dietmar, Hujer Nicole, Incesoy Enise Irem, Kainz Christian, Lange Catharina, Lindner Katja, Megges Herlind, Peters Oliver, Preis Lukas, Altenstein Slawek, Lohse Andrea, Franke Christiana, Priller Josef, Spruth Eike, Villar Munoz Irene, Barkhoff Miriam, Boecker Henning, Brosseron Frederic, Daamen Marcel, Engels Tanja, Faber Jennifer, Fließbach Klaus, Frommann Ingo, Grobe-Einsler Marcus, Hennes Guido, Herrmann Gabi, Jost Lorraine, Kalbhen Pascal, Kimmich Okka, Kobeleva Xenia, Kofler Barbara, McCormick Cornelia, Miebach Lisa, Miklitz Carolin, Müller Anna, Oender Demet, Polcher Alexandra, Purrer Veronika, Röske Sandra, Schneider Christine, Schneider Anja, Spottke Annika, Vogt Ina, Wagner Michael, wolfsgruber Steffen, Yilmaz Sagik, Bartels Claudia, Dechent Peter, Hansen Niels, Hassoun Lina, Hirschel Sina, Nuhn Sabine, Pfahlert Ilona, Rausch Lena, Schott Björn, Timäus Charles, Werner Christine, Wiltfang Jens, Zabel Lioba, Zech Heike, Bader Abdelmajid, Baldermann Juan Carlos, Dölle Britta, Drzezga Alexander, Escher Claus, Ghiasi Nasim Roshan, Hardenacke Katja, Jessen Frank, Lützerath Hannah, Maier Franziska, Marquardt Benjamin, Martikke Anja, Meiberth Dix, Petzler Snjezana, Rostamzadeh Ayda, Sannemann Lena, Schild Ann-Katrin, Sorgalla Susanne, Stockter Simone, Thelen Manuela, Tscheuschler Maike, Uhle Franziska, Zeyen Philip, Bittner Daniel, Cardenas-Blanco Arturo, Dobisch Laura, Düzel Emrah, Grieger-Klose Doreen, Hartmann Deike, Metzger Coraline, Nestor Peter, Ruß Christin, Schulze Franziska, Speck Oliver, Yakupov Renat, Ziegler Gabriel, Brauneis Christine, Bürger Katharina, Catak Cihan, Coloma Andrews Lisa, Dichgans Martin, Dörr Angelika, Ertl-Wagner Birgit, Frimmer Daniela, Huber Brigitte, Janowitz Daniel, Kreuzer Max, Markov Eva, Müller Claudia, Rominger Axel, Schmid (ehemals Spreider) Jennifer, Seegerer Anna, Stephan Julia, Zollver Adelgunde, Burow Lena, de Jonge Sylvia, Falkai Peter, Garcia Angarita Natalie, Görlitz Thomas, Gürsel Selim Üstün, Horvath Ildiko, Kurz Carolin, Meisenzahl-Lechner Eva, Perneczky Robert, Utecht Julia, Dyrba Martin, Janecek-Meyer Heike, Kilimann Ingo, Lappe Chris, Lau Esther, Pfaff Henrike, Raum Heike, Sabik Petr, Schmidt Monika, Schulz Heike, Schwarzenboeck Sarah, Teipel Stefan, Weber Marc-Andre, Buchmann Martina, Heger Tanja, Hinderer Petra, Kuder-Buletta Elke, Laske Christoph, Munk Matthias, Mychajliw Christian, Soekadar Surjo, sulzer Patricia, and Trunk Theresia

Subjects
white matter hyperintensities segmentation, evaluation, FLAIR, deep learning, aging, Alzheimer’s disease, Psychiatry, RC435-571
Abstract

BackgroundWhite matter hyperintensities (WMH), a biomarker of small vessel disease, are often found in Alzheimer’s disease (AD) and their advanced detection and quantification can be beneficial for research and clinical applications. To investigate WMH in large-scale multicenter studies on cognitive impairment and AD, appropriate automated WMH segmentation algorithms are required. This study aimed to compare the performance of segmentation tools and provide information on their application in multicenter research.MethodsWe used a pseudo-randomly selected dataset (n = 50) from the DZNE-multicenter observational Longitudinal Cognitive Impairment and Dementia Study (DELCODE) that included 3D fluid-attenuated inversion recovery (FLAIR) images from participants across the cognitive continuum. Performances of top-rated algorithms for automated WMH segmentation [Brain Intensity Abnormality Classification Algorithm (BIANCA), lesion segmentation toolbox (LST), lesion growth algorithm (LGA), LST lesion prediction algorithm (LPA), pgs, and sysu_media] were compared to manual reference segmentation (RS).ResultsAcross tools, segmentation performance was moderate for global WMH volume and number of detected lesions. After retraining on a DELCODE subset, the deep learning algorithm sysu_media showed the highest performances with an average Dice’s coefficient of 0.702 (±0.109 SD) for volume and a mean F1-score of 0.642 (±0.109 SD) for the number of lesions. The intra-class correlation was excellent for all algorithms (>0.9) but BIANCA (0.835). Performance improved with high WMH burden and varied across brain regions.ConclusionTo conclude, the deep learning algorithm, when retrained, performed well in the multicenter context. Nevertheless, the performance was close to traditional methods. We provide methodological recommendations for future studies using automated WMH segmentation to quantify and assess WMH along the continuum of cognitive impairment and AD dementia.

Published
2023
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3. Case report: Amnestic mild cognitive impairment in multiple domains associated with neurofascin 186 autoantibodies: Case series with follow-up and review

Author

Niels Hansen, Anne Sagebiel, Kristin Rentzsch, Sina Hirschel, Jens Wiltfang, Björn H. Schott, and Bartels Claudia

Subjects
autoantibody, autoimmunity, cognition, neurofascin 186 antibody, mild cognitive impairment, Psychiatry, RC435-571
Abstract

BackgroundNeurofascin 186 autoantibodies are known to occur with a diseased peripheral nervous system. Recently, also additional central nervous system (CNS) involvement has been reported in conjunction with neurofascin 186 autoantibodies. Our case enlarges the spectrum of neurofascin 186 antibody-related disease to include mild cognitive impairment (MCI).MethodsWe report here a case after having examined the patient files retrospectively, including diagnostics such as blood and cerebrospinal fluid (CSF) analysis involving the determination of neural autoantibodies, brain magnetic resonance imaging (MRI), brain fluorodesoxyglucose positron emission tomography (FDG-PET), and extensive neuropsychological testing.ResultsWe report on two patients with MCI. Brain MRI showed cerebral microangiopathy in both patients, but brain FDG-PET demonstrated pathology in the right prefrontal cortex, in the right inferior parietal cortex, and in both lateral occipital cortices in one patient. Neurofascin 186 antibodies were detected in serum in both patients, and neurofascin 186 autoantibodies were also detected in the CSF of one of these patients. At follow-up six month later, neurofascin 186 autoantibodies disappeared in one patient while persisting in the other.ConclusionWe report on two individuals presenting MCI associated with neurofascin 186 antibodies, thus expanding the potential spectrum of neurofascin 186-associated disease. This report supports the recommendation to consider also neurofascin 186 autoantibodies in not just peripheral nerve disease, but also in disorders involving CNS autoimmunity. More studies are needed to clarify the lack of association between neurofascin 186 autoantibodies and cognitive decline.

Published
2023
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5. Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study

Author

Menze, Inga, Bernal, Jose, Kaya, Pinar, Aki, Çağla, Pfister, Malte, Geisendörfer, Jonas, Yakupov, Renat, Coello, Roberto Duarte, Valdés-Hernández, Maria d. C., Heneka, Michael T., Brosseron, Frederic, Schmid, Matthias C., Glanz, Wenzel, Incesoy, Enise I., Butryn, Michaela, Rostamzadeh, Ayda, Meiberth, Dix, Peters, Oliver, Preis, Lukas, Lammerding, Dominik, Gref, Daria, Priller, Josef, Spruth, Eike J., Altenstein, Slawek, Lohse, Andrea, Hetzer, Stefan, Schneider, Anja, Fliessbach, Klaus, Kimmich, Okka, Vogt, Ina R., Wiltfang, Jens, Bartels, Claudia, Schott, Björn H., Hansen, Niels, Dechent, Peter, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Goerss, Doreen, Laske, Christoph, Munk, Matthias H., Sanzenbacher, Carolin, Hinderer, Petra, Scheffler, Klaus, Spottke, Annika, Roy-Kluth, Nina, Lüsebrink, Falk, Neumann, Katja, Wardlaw, Joanna, Jessen, Frank, Schreiber, Stefanie, Düzel, Emrah, and Ziegler, Gabriel

Published
2024
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6. Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition

Author

Hayek, Dayana, Ziegler, Gabriel, Kleineidam, Luca, Brosseron, Frederic, Nemali, Aditya, Vockert, Niklas, Ravichandran, Kishore A., Betts, Matthew J., Peters, Oliver, Schneider, Luisa-Sophie, Wang, Xiao, Priller, Josef, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Bartels, Claudia, Rostamzadeh, Ayda, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Kilimann, Ingo, Laske, Christoph, Mengel, David, Synofzik, Matthis, Munk, Matthias H., Spottke, Annika, Roy, Nina, Roeske, Sandra, Kuhn, Elizabeth, Ramirez, Alfredo, Dobisch, Laura, Schmid, Matthias, Berger, Moritz, Wolfsgruber, Steffen, Yakupov, Renat, Hetzer, Stefan, Dechent, Peter, Ewers, Michael, Scheffler, Klaus, Schott, Björn H., Schreiber, Stefanie, Orellana, Adelina, de Rojas, Itziar, Marquié, Marta, Boada, Mercè, Sotolongo, Oscar, González, Pablo García, Puerta, Raquel, Düzel, Emrah, Jessen, Frank, Wagner, Michael, Ruiz, Augustín, Heneka, Michael T., and Maass, Anne

Published
2024
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8. Exploring the ATN classification system using brain morphology

Author

Heinzinger, Nils, Maass, Anne, Berron, David, Yakupov, Renat, Peters, Oliver, Fiebach, Jochen, Villringer, Kersten, Preis, Lukas, Priller, Josef, Spruth, Eike Jacob, Altenstein, Slawek, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Bartels, Claudia, Jessen, Frank, Maier, Franziska, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Teipel, Stefan, Killimann, Ingo, Göerß, Doreen, Laske, Christoph, Munk, Matthias H., Spottke, Annika, Roy, Nina, Heneka, Michael T., Brosseron, Frederic, Dobisch, Laura, Ewers, Michael, Dechent, Peter, Haynes, John Dylan, Scheffler, Klaus, Wolfsgruber, Steffen, Kleineidam, Luca, Schmid, Matthias, Berger, Moritz, Düzel, Emrah, and Ziegler, Gabriel

Published
2023
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9. Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia

Author

Ruiz-Rizzo, Adriana L., Finke, Kathrin, Damoiseaux, Jessica S., Bartels, Claudia, Buerger, Katharina, Cosma, Nicoleta Carmen, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Glanz, Wenzel, Goerss, Doreen, Hetzer, Stefan, Incesoy, Enise I., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, van Lent, Debora Melo, Munk, Matthias H.J., Peters, Oliver, Priller, Josef, Ramirez, Alfredo, Rostamzadeh, Ayda, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan, Wagner, Michael, Wiltfang, Jens, Yakupov, Renat, Jessen, Frank, Duezel, Emrah, Perneczky, Robert, and Rauchmann, Boris-Stephan

Published
2024
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10. Practice effects in healthy adults: A longitudinal study on frequent repetitive cognitive testing

Author

Ackermann Verena, Wiedl Anne, Wegrzyn Martin, Bartels Claudia, and Ehrenreich Hannelore

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Cognitive deterioration is a core symptom of many neuropsychiatric disorders and target of increasing significance for novel treatment strategies. Hence, its reliable capture in long-term follow-up studies is prerequisite for recording the natural course of diseases and for estimating potential benefits of therapeutic interventions. Since repeated neuropsychological testing is required for respective longitudinal study designs, occurrence, time pattern and magnitude of practice effects on cognition have to be understood first under healthy good-performance conditions to enable design optimization and result interpretation in disease trials. Methods Healthy adults (N = 36; 47.3 ± 12.0 years; mean IQ 127.0 ± 14.1; 58% males) completed 7 testing sessions, distributed asymmetrically from high to low frequency, over 1 year (baseline, weeks 2-3, 6, 9, months 3, 6, 12). The neuropsychological test battery covered 6 major cognitive domains by several well-established tests each. Results Most tests exhibited a similar pattern upon repetition: (1) Clinically relevant practice effects during high-frequency testing until month 3 (Cohen's d 0.36-1.19), most pronounced early on, and (2) a performance plateau thereafter upon low-frequency testing. Few tests were non-susceptible to practice or limited by ceiling effects. Influence of confounding variables (age, IQ, personality) was minor. Conclusions Practice effects are prominent particularly in the early phase of high-frequency repetitive cognitive testing of healthy well-performing subjects. An optimal combination and timing of tests, as extractable from this study, will aid in controlling their impact. Moreover, normative data for serial testing may now be collected to assess normal learning curves as important comparative readout of pathological cognitive processes.

Published
2010
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11. Linking early-life bilingualism and cognitive advantage in older adulthood

Author

Ballarini, Tommaso, Kuhn, Elizabeth, Röske, Sandra, Altenstein, Slawek, Bartels, Claudia, Buchholz, Friederike, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Gabelin, Tatjana, Glanz, Wenzel, Görß, Doreen, Haynes, John Dylan, Incesoy, Enise I., Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, Kobeleva, Xenia, Laske, Christoph, Lohse, Andrea, Maier, Franziska, Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Priller, Josef, Rauchmann, Boris-Stephan, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Schott, Björn H., Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Düzel, Emrah, Jessen, Frank, and Wagner, Michael

Published
2023
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12. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease

Author

Ersoezlue, Ersin, Rauchmann, Boris-Stephan, Schneider-Axmann, Thomas, Wagner, Michael, Ballarini, Tommaso, Tato, Maia, Utecht, Julia, Kurz, Carolin, Papazov, Boris, Guersel, Selim, Burow, Lena, Koller, Gabriele, Stöcklein, Sophia, Keeser, Daniel, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cetindag, Arda C., Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Haynes, John D., Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Maier, Franziska, Metzger, Coraline D., Munk, Matthias H., Peters, Oliver, Preis, Lukas, Priller, Josef, Ramirez, Alfredo, Roeske, Sandra, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Wiltfang, Jens, Wolfsgruber, Steffen, Yakupov, Renat, Duezel, Emrah, Jessen, Frank, and Perneczky, Robert

Published
2023
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13. Medium-term and peri-lockdown course of psychosocial burden during the ongoing COVID-19 pandemic: a longitudinal study on patients with pre-existing mental disorders

Author

Bartels, Claudia, Hessmann, Philipp, Schmidt, Ulrike, Vogelgsang, Jonathan, Ruhleder, Mirjana, Kratzenberg, Alexander, Treptow, Marit, Reh-Bergen, Thorgund, Abdel-Hamid, Mona, Heß, Luisa, Meiser, Miriam, Signerski-Krieger, Jörg, Radenbach, Katrin, Trost, Sarah, Schott, Björn H., Wiltfang, Jens, Wolff-Menzler, Claus, and Belz, Michael

Published
2022
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14. Machine Learning-Based Perivascular Space Volumetry in Alzheimer Disease.

Author

Deike, Katerina, Decker, Andreas, Scheyhing, Paul, Harten, Julia, Zimmermann, Nadine, Paech, Daniel, Peters, Oliver, Freiesleben, Silka D., Schneider, Luisa-Sophie, Preis, Lukas, Priller, Josef, Spruth, Eike, Altenstein, Slawek, Lohse, Andrea, Fliessbach, Klaus, Kimmich, Okka, Wiltfang, Jens, Bartels, Claudia, Hansen, Niels, and Jessen, Frank

Published
2024
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16. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease

Author

Franzmeier, Nicolai, Düzel, Emrah, Jessen, Frank, Buerger, Katharina, Levin, Johannes, Duering, Marco, Dichgans, Martin, Haass, Christian, Suárez-Calvet, Marc, Fagan, Anne M, Paumier, Katrina, Benzinger, Tammie, Masters, Colin L, Morris, John C, Perneczky, Robert, Janowitz, Daniel, Catak, Cihan, Wolfsgruber, Steffen, Wagner, Michael, Teipel, Stefan, Kilimann, Ingo, Ramirez, Alfredo, Rossor, Martin, Jucker, Mathias, Chhatwal, Jasmeer, Spottke, Annika, Boecker, Henning, Brosseron, Frederic, Falkai, Peter, Fliessbach, Klaus, Heneka, Michael T, Laske, Christoph, Nestor, Peter, Peters, Oliver, Fuentes, Manuel, Menne, Felix, Priller, Josef, Spruth, Eike J, Franke, Christiana, Schneider, Anja, Kofler, Barbara, Westerteicher, Christine, Speck, Oliver, Wiltfang, Jens, Bartels, Claudia, Caballero, Miguel Ángel Araque, Metzger, Coraline, Bittner, Daniel, Weiner, Michael, Lee, Jae-Hong, Salloway, Stephen, Danek, Adrian, Goate, Alison, Schofield, Peter R, Bateman, Randall J, and Ewers, Michael

Subjects
Clinical Trials and Supportive Activities, Brain Disorders, Aging, Basic Behavioral and Social Science, Dementia, Neurosciences, Behavioral and Social Science, Acquired Cognitive Impairment, Clinical Research, Alzheimer's Disease, Neurodegenerative, Biomedical Imaging, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aetiology, 2.1 Biological and endogenous factors, Neurological, Adult, Alzheimer Disease, Amyloid beta-Protein Precursor, Brain Mapping, Cognitive Dysfunction, Female, Frontal Lobe, Functional Laterality, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Middle Aged, Mutation, Nerve Net, Presenilin-1, Presenilin-2, Alzheimer's disease, cognitive reserve, resting state connectivity, memory, dementia biomarkers, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may support higher reserve capacity, i.e. relatively high cognitive performance at a given level of Alzheimer's pathology. Higher functional MRI-assessed functional connectivity of a hub in the left frontal cortex is a core candidate brain mechanism underlying reserve as it is associated with education (i.e. a protective factor often associated with higher reserve) and attenuated cognitive impairment in prodromal Alzheimer's disease. However, no study has yet assessed whether such hub connectivity of the left frontal cortex supports reserve throughout the evolution of pathological brain changes in Alzheimer's disease, including the presymptomatic stage when cognitive decline is subtle. To address this research gap, we obtained cross-sectional resting state functional MRI in 74 participants with autosomal dominant Alzheimer's disease, 55 controls from the Dominantly Inherited Alzheimer's Network and 75 amyloid-positive elderly participants, as well as 41 amyloid-negative cognitively normal elderly subjects from the German Center of Neurodegenerative Diseases multicentre study on biomarkers in sporadic Alzheimer's disease. For each participant, global left frontal cortex connectivity was computed as the average resting state functional connectivity between the left frontal cortex (seed) and each voxel in the grey matter. As a marker of disease stage, we applied estimated years from symptom onset in autosomal dominantly inherited Alzheimer's disease and cerebrospinal fluid tau levels in sporadic Alzheimer's disease cases. In both autosomal dominant and sporadic Alzheimer's disease patients, higher levels of left frontal cortex connectivity were correlated with greater education. For autosomal dominant Alzheimer's disease, a significant left frontal cortex connectivity × estimated years of onset interaction was found, indicating slower decline of memory and global cognition at higher levels of connectivity. Similarly, in sporadic amyloid-positive elderly subjects, the effect of tau on cognition was attenuated at higher levels of left frontal cortex connectivity. Polynomial regression analysis showed that the trajectory of cognitive decline was shifted towards a later stage of Alzheimer's disease in patients with higher levels of left frontal cortex connectivity. Together, our findings suggest that higher resilience against the development of cognitive impairment throughout the early stages of Alzheimer's disease is at least partially attributable to higher left frontal cortex-hub connectivity.

Published
2018

19. Symptomatic Clusters Related to Amyloid Positivity in Cognitively Unimpaired Individuals.

Author

Sannemann, Lena, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Glanz, Wenzel, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, Lammerding, Dominik, Laske, Christoph, Munk, Matthias H.J., Perneczky, Robert, Peters, Oliver, Priller, Josef, Rauchmann, Boris-Stephan, and Rostamzadeh, Ayda

Subjects
*AMYLOID, *ALZHEIMER'S disease, *COGNITIVE interviewing, *CEREBROSPINAL fluid, *COGNITION disorders
Abstract

Background: The NIA-AA Research Framework on Alzheimer's disease (AD) proposes a transitional stage (stage 2) characterized by subtle cognitive decline, subjective cognitive decline (SCD) and mild neurobehavioral symptoms (NPS). Objective: To identify participant clusters based on stage 2 features and assess their association with amyloid positivity in cognitively unimpaired individuals. Methods: We included baseline data of N = 338 cognitively unimpaired participants from the DELCODE cohort with data on cerebrospinal fluid biomarkers for AD. Classification into the AD continuum (i.e., amyloid positivity, A+) was based on Aβ42/40 status. Neuropsychological test data were used to assess subtle objective cognitive dysfunction (OBJ), the subjective cognitive decline interview (SCD-I) was used to detect SCD, and the Neuropsychiatric Inventory Questionnaire (NPI-Q) was used to assess NPS. A two-step cluster analysis was carried out and differences in AD biomarkers between clusters were analyzed. Results: We identified three distinct participant clusters based on presented symptoms. The highest rate of A+ participants (47.6%) was found in a cluster characterized by both OBJ and SCD. A cluster of participants that presented with SCD and NPS (A+:26.6%) and a cluster of participants with overall few symptoms (A+:19.7%) showed amyloid positivity in a range that was not higher than the expected A+ rate for the age group. Across the full sample, participants with a combination of SCD and OBJ in the memory domain showed a lower Aβ42/ptau181 ratio compared to those with neither SCD nor OBJ. Conclusions: The cluster characterized by participants with OBJ and concomitant SCD was enriched for amyloid pathology. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease

Author

Franzmeier, Nicolai, Ren, Jinyi, Damm, Alexander, Monté-Rubio, Gemma, Boada, Mercè, Ruiz, Agustín, Ramirez, Alfredo, Jessen, Frank, Düzel, Emrah, Rodríguez Gómez, Octavio, Benzinger, Tammie, Goate, Alison, Karch, Celeste M., Fagan, Anne M., McDade, Eric, Buerger, Katharina, Levin, Johannes, Duering, Marco, Dichgans, Martin, Suárez-Calvet, Marc, Haass, Christian, Gordon, Brian A., Lim, Yen Ying, Masters, Colin L., Janowitz, Daniel, Catak, Cihan, Wolfsgruber, Steffen, Wagner, Michael, Milz, Esther, Moreno-Grau, Sonia, Teipel, Stefan, Grothe, Michel J, Kilimann, Ingo, Rossor, Martin, Fox, Nick, Laske, Christoph, Chhatwal, Jasmeer, Falkai, Peter, Perneczky, Robert, Lee, Jae-Hong, Spottke, Annika, Boecker, Henning, Brosseron, Frederic, Fliessbach, Klaus, Heneka, Michael T., Nestor, Peter, Peters, Oliver, Fuentes, Manuel, Menne, Felix, Priller, Josef, Spruth, Eike J., Franke, Christiana, Schneider, Anja, Westerteicher, Christine, Speck, Oliver, Wiltfang, Jens, Bartels, Claudia, Araque Caballero, Miguel Ángel, Metzger, Coraline, Bittner, Daniel, Salloway, Stephen, Danek, Adrian, Hassenstab, Jason, Yakushev, Igor, Schofield, Peter R., Morris, John C., Bateman, Randall J., and Ewers, Michael

Published
2021
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22. Early Detection of Alzheimer’s Disease using microRNAs

Author

Heuvelman, Marco, primary, Horos, Rastislav, additional, Sikosek, Tobias, additional, Tikk, Kaja, additional, Rajakumar, Timothy, additional, Cummings, Jeffrey L., additional, Hansen, Niels, additional, Bartels, Claudia, additional, Oberstein, Timo Jan, additional, Hausner, Lucrezia, additional, Wiltfang, Jens, additional, Frölich, Lutz, additional, and Steinkraus, Bruno R, additional

Published
2023
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23. Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment

Author

Bainbridge, Wilma A., Berron, David, Schütze, Hartmut, Cardenas-Blanco, Arturo, Metzger, Coraline, Dobisch, Laura, Bittner, Daniel, Glanz, Wenzel, Spottke, Annika, Rudolph, Janna, Brosseron, Frederic, Buerger, Katharina, Janowitz, Daniel, Fliessbach, Klaus, Heneka, Michael, Laske, Christoph, Buchmann, Martina, Peters, Oliver, Diesing, Dominik, Li, Siyao, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Schneider, Anja, Kofler, Barbara, Teipel, Stefan, Kilimann, Ingo, Wiltfang, Jens, Bartels, Claudia, Wolfsgruber, Steffen, Wagner, Michael, Jessen, Frank, Baker, Chris I., and Düzel, Emrah

Published
2019
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24. Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer’s disease from bioptic olfactory mucosa

Author

Pellkofer, Hannah, Ihler, Friedrich, Weiss, Bernhard G., Trothe, Janina, Kadavath, Harindranath, Chongtham, Monika, Kunadt, Marcel, Riedel, Dietmar, Lornsen, Finn, Wilken, Petra, Bartels, Claudia, Hirschel, Sina, Russo, Sebastian G., Stransky, Elke, Trojan, Lutz, Schmidt, Boris, Mandelkow, Eckhardt, Zweckstetter, Markus, Canis, Martin, and Schneider, Anja

Published
2019
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25. A microRNA signature that correlates with cognition and is a target against cognitive decline

Author

Islam, Md Rezaul, Kaurani, Lalit, Berulava, Tea, Heilbronner, Urs, Budde, Monika, Centeno, Tonatiuh Pena, Elerdashvili, Vakthang, Zafieriou, Maria‐Patapia, Benito, Eva, Sertel, Sinem M, Goldberg, Maria, Senner, Fanny, Kalman, Janos L, Burkhardt, Susanne, Oepen, Anne Sophie, Sakib, Mohammad Sadman, Kerimoglu, Cemil, Wirths, Oliver, Bickeböller, Heike, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cosma, Nicoleta‐Carmen, Fliessbach, Klaus, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Metzger, Coraline D, Munk, Matthias H, Perneczky, Robert, Peters, Oliver, Priller, Josef, Rauchmann, Boris S., Roy, Nina, Schneider, Anja, Spottke, Annika, Spruth, Eike J, Teipel, Stefan, Tscheuschler, Maike, Wagner, Michael, Wiltfang, Jens, Düzel, Emrah, Jessen, Frank, Rizzoli, Silvio O, Zimmermann, Wolfram‐Hubertus, Schulze, Thomas G, Falkai, Peter, Sananbenesi, Farahnaz, and Fischer, Andre

Published
2021
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27. Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline

Author

Stark, Melina, primary, Wolfsgruber, Steffen, additional, Kleineidam, Luca, additional, Frommann, Ingo, additional, Altenstein, Slawek, additional, Bartels, Claudia, additional, Brosseron, Frederic, additional, Buerger, Katharina, additional, Burow, Lena, additional, Butryn, Michaela, additional, Ewers, Michael, additional, Fliessbach, Klaus, additional, Gabelin, Tatjana, additional, Glanz, Wenzel, additional, Goerss, Doreen, additional, Gref, Daria, additional, Hansen, Niels, additional, Heneka, Michael T., additional, Hinderer, Petra, additional, Incesoy, Enise I, additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Kimmich, Okka, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Perneczky, Robert, additional, Peters, Oliver, additional, Preis, Lukas, additional, Priller, Josef, additional, Rauchmann, Boris-Stephan, additional, Rostamzadeh, Ayda, additional, Roy-Kluth, Nina, additional, Sanzenbacher, Carolin, additional, Schneider, Anja, additional, Schott, Björn H., additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, Vogt, Ina R, additional, Wiltfang, Jens, additional, Duzel, Emrah, additional, Jessen, Frank, additional, and Wagner, Michael, additional

Published
2023
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28. Perivascular space enlargement accelerates with hypertension, white matter hyperintensities, chronic inflammation, and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study

Author

Menze, Inga, primary, Bernal, Jose, additional, Kaya, Pinar, additional, Aki, Çağla, additional, Pfister, Malte, additional, Geisendörfer, Jonas, additional, Yakupov, Renat, additional, Heneka, Michael T., additional, Brosseron, Frederic, additional, Schmid, Matthias C., additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Butryn, Michaela, additional, Rostamzadeh, Ayda, additional, Meiberth, Dix, additional, Peters, Oliver, additional, Preis, Lukas, additional, Lammerding, Dominik, additional, Gref, Daria, additional, Priller, Josef, additional, Spruth, Eike J., additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Hetzer, Stefan, additional, Schneider, Anja, additional, Fliessbach, Klaus, additional, Kimmich, Okka, additional, Vogt, Ina R., additional, Wiltfang, Jens, additional, Bartels, Claudia, additional, Schott, Björn H., additional, Hansen, Niels, additional, Dechent, Peter, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Goerss, Doreen, additional, Laske, Christoph, additional, Munk, Matthias H., additional, Sanzenbacher, Carolin, additional, Hinderer, Petra, additional, Scheffler, Klaus, additional, Spottke, Annika, additional, Roy-Kluth, Nina, additional, Lüsebrink, Falk, additional, Neumann, Katja, additional, Jessen, Frank, additional, Schreiber, Stefanie, additional, Düzel, Emrah, additional, and Ziegler, Gabriel, additional

Published
2023
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31. CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Author

Düzel, Emrah, Berron, David, Schütze, Hartmut, Cardenas-Blanco, Arturo, Metzger, Coraline, Betts, Matthew, Ziegler, Gabriel, Chen, Yi, Dobisch, Laura, Bittner, Daniel, Glanz, Wenzel, Reuter, Martin, Spottke, Annika, Rudolph, Janna, Brosseron, Frederic, Buerger, Katharina, Janowitz, Daniel, Fliessbach, Klaus, Heneka, Michael, Laske, Christoph, Buchmann, Martina, Nestor, Peter, Peters, Oliver, Diesing, Dominik, Li, Siyao, Priller, Josef, Spruth, Eike Jakob, Altenstein, Slawek, Ramirez, Alfredo, Schneider, Anja, Kofler, Barbara, Speck, Oliver, Teipel, Stefan, Kilimann, Ingo, Dyrba, Martin, Wiltfang, Jens, Bartels, Claudia, Wolfsgruber, Steffen, Wagner, Michael, and Jessen, Frank

Published
2018
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32. Symptomatic clusters related to amyloid positivity in cognitively unimpaired individuals

Author

Sannemann, Lena, primary, Bartels, Claudia, additional, Brosseron, Frederic, additional, Buerger, Katharina, additional, Fliessbach, Klaus, additional, Freiesleben, Silka Dawn, additional, Frommann, Ingo, additional, Glanz, Wenzel, additional, Heneka, Michael T., additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Kleineidam, Luca, additional, Lammerding, Dominik, additional, Laske, Christoph, additional, Munk, Matthias H. J., additional, Perneczky, Robert, additional, Peters, Oliver, additional, Priller, Josef, additional, Rauchmann, Boris-Stephan, additional, Rostamzadeh, Ayda, additional, Roy-Kluth, Nina, additional, Schild, Ann-Katrin, additional, Schneider, Anja, additional, Schneider, Luisa-Sophie, additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, Wagner, Michael, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Duezel, Emrah, additional, and Jessen, Frank, additional

Published
2023
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35. Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease

Author

Billette, Ornella V, Ziegler, Gabriel, Dahmen, Philip, Dechent, Peter, Dobisch, Laura, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Göerß, Doreen, Haynes, John Dylan, Heneka, Michael T, Kilimann, Ingo, Aruci, Merita, Kimmich, Okka, Kleineidam, Luca, Laske, Christoph, Lohse, Andrea, Rostamzadeh, Ayda, Metzger, Coraline, Munk, Matthias H, Peters, Oliver, Preis, Lukas, Priller, Josef, Schütze, Hartmut, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Ramirez, Alfredo, Röske, Sandra, Roy, Nina, Teipel, Stefan, Wagner, Michael, Wiltfang, Jens, Kizilirmak, Jasmin M, Wolfsgruber, Steffen, Yakupov, Renat, Zeidman, Peter, Jessen, Frank, Schott, Björn, Düzel, Emrah, Maass, Anne, Group, DELCODE Study, Richter, Anni, Altenstein, Slawek, Bartels, Claudia, Brosseron, Frederic, and Cardenas-Blanco, Arturo

Subjects
Alzheimer Disease/diagnosis, Amyloid beta-Peptides, Cognitive Dysfunction/diagnostic imaging, diagnosis [Alzheimer Disease], diagnostic imaging [Cognitive Dysfunction], Magnetic Resonance Imaging, Temporal Lobe/diagnostic imaging, Temporal Lobe, Magnetic Resonance Imaging/methods, diagnostic imaging [Parietal Lobe], Parietal Lobe/diagnostic imaging, methods [Magnetic Resonance Imaging], diagnostic imaging [Temporal Lobe], Alzheimer Disease, Parietal Lobe, Humans, Cognitive Dysfunction, ddc:610, Neurology (clinical), Biomarkers
Abstract

Background and ObjectivesWe assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy.MethodsWe studied 499 participants aged 60–88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of β-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education.ResultsIn the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers.DiscussionNovelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.

Published
2022

37. A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease

Author

Rauchmann, Boris-Stephan, primary, Gross, Patrizia, additional, Ersoezlue, Ersin, additional, Wagner, Michael, additional, Tommaso, Ballarini, additional, Kurz, Carolin, additional, Tatò, Maia, additional, Utecht, Julia, additional, Papazov, Boris, additional, Guersel, Selim, additional, Totzke, Marie, additional, Trappmann, Lena, additional, Burow, Lena, additional, Koller, Gabriele, additional, Stöcklein, Sophia, additional, Keeser, Daniel, additional, Altenstein, Slawek, additional, Bartels, Claudia, additional, Buerger, Katharina, additional, Dechent, Peter, additional, Dobisch, Laura, additional, Ewers, Michael, additional, Fliessbach, Klaus, additional, Freiesleben, Silka Dawn, additional, Glanz, Wenzel, additional, Goeerss, Doreen, additional, Gref, Daria, additional, Haynes, John Dylan, additional, Janowitz, Daniel, additional, Kilimann, Ingo, additional, Kimmich, Okka, additional, Kleineidam, Luca, additional, Laske, Christoph, additional, Lohse, Andrea, additional, Maier, Franziska, additional, Metzger, Coraline D., additional, Munk, Matthias H., additional, Peters, Oliver, additional, Preis, Lukas, additional, Priller, Josef, additional, Roeske, Sandra, additional, Roy, Nina, additional, Sanzenbacher, Carolin, additional, Scheffler, Klaus, additional, Schneider, Anja, additional, Schott, Björn Hendrik, additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, van Lent, Debora Melo, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Yakupov, Renat, additional, Düzel, Emrah, additional, Jessen, Frank, additional, and Perneczky, Robert, additional

Published
2023
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38. 7 .Differentialdiagnostik

Author

Hamann, Gerhard F, primary, Dodel, Richard, additional, Otto, Markus, additional, Feneberg, Emily, additional, Anderl-Straub, Sarah, additional, Schneider, Anja, additional, and Bartels, Claudia, additional

Published
2018
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39. Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

Author

Miebach, Lisa, Wolfsgruber, Steffen, Polcher, Alexandra, Peters, Oliver, Menne, Felix, Luther, Katja, Incesoy, Enise, Priller, Josef, Spruth, Eike, Altenstein, Slawek, Buerger, Katharina, Catak, Cihan, Janowitz, Daniel, Perneczky, Robert, Utecht, Julia, Laske, Christoph, Buchmann, Martina, Schneider, Anja, Fliessbach, Klaus, Kalbhen, Pascal, Heneka, Michael T., Brosseron, Frederic, Spottke, Annika, Roy, Nina, Teipel, Stefan J., Kilimann, Ingo, Wiltfang, Jens, Bartels, Claudia, Düzel, Emrah, Dobisch, Laura, Metzger, Coraline, Meiberth, Dix, Ramirez, Alfredo, Jessen, Frank, and Wagner, Michael

Published
2019
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40. Long-term environmental enrichment is associated with better fornix microstructure in older adults.

Author

Klimecki, Olga M., Liebscher, Maxie, Gaubert, Malo, Hayek, Dayana, Zarucha, Alexis, Dyrba, Martin, Bartels, Claudia, Buerger, Katharina, Butryn, Michaela, Dechent, Peter, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Freiesleben, Silka Dawn, Glanz, Wenzel, Hetzer, Stefan, Janowitz, Daniel, Kilimann, Ingo, Kleineidam, Luca, and Laske, Christoph

Subjects
ALZHEIMER'S disease prevention, BRAIN physiology, LEISURE, STATISTICS, CONFIDENCE intervals, CROSS-sectional method, MAGNETIC resonance imaging, DESCRIPTIVE statistics, CHI-squared test, RESEARCH funding, DATA analysis software, COMPUTER-assisted image analysis (Medicine), DATA analysis, LONGITUDINAL method, OLD age
Abstract

Background: Sustained environmental enrichment (EE) through a variety of leisure activities may decrease the risk of developing Alzheimer’s disease. This cross-sectional cohort study investigated the association between long-term EE in young adulthood through middle life and microstructure of fiber tracts associated with the memory system in older adults. Methods: N = 201 cognitively unimpaired participants (≥ 60 years of age) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) baseline cohort were included. Two groups of participants with higher (n = 104) or lower (n = 97) long-term EE were identified, using the self-reported frequency of diverse physical, intellectual, and social leisure activities between the ages 13 to 65. White matter (WM) microstructure was measured by fractional anisotropy (FA) and mean diffusivity (MD) in the fornix, uncinate fasciculus, and parahippocampal cingulum using diffusion tensor imaging. Long-term EE groups (lower/higher) were compared with adjustment for potential confounders, such as education, crystallized intelligence, and socio-economic status. Results: Reported participation in higher long-term EE was associated with greater fornix microstructure, as indicated by higher FA (standardized β = 0.117, p = 0.033) and lower MD (β = −0.147, p = 0.015). Greater fornix microstructure was indirectly associated (FA: unstandardized B = 0.619, p = 0.038; MD: B = −0.035, p = 0.026) with better memory function through higher long-term EE. No significant effects were found for the other WM tracts. Conclusion: Our findings suggest that sustained participation in a greater variety of leisure activities relates to preserved WM microstructure in the memory system in older adults. This could be facilitated by the multimodal stimulation associated with the engagement in a physically, intellectually, and socially enriched lifestyle. Longitudinal studies will be needed to support this assumption. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Apathy in patients with Alzheimer's disease is a cost‐driving factor

Author

Kruse, Christopher, primary, Maier, Franziska, additional, Spottke, Annika, additional, Bach, Jan‐Philipp, additional, Bartels, Claudia, additional, Buerger, Katharina, additional, Fellgiebel, Andreas, additional, Fliessbach, Klaus, additional, Frölich, Lutz, additional, Hausner, Lucrezia, additional, Hellmich, Martin, additional, Klöppel, Stefan, additional, Klostermann, Arne, additional, Kornhuber, Johannes, additional, Laske, Christoph, additional, Peters, Oliver, additional, Priller, Josef, additional, Richter‐Schmidinger, Tanja, additional, Schneider, Anja, additional, Shah‐Hosseini, Kija, additional, Teipel, Stefan, additional, von Arnim, Christine A. F., additional, Wiltfang, Jens, additional, van der Wurp, Hendrik, additional, Dodel, Richard, additional, and Jessen, Frank, additional

Published
2023
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43. Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve

Author

Kleineidam, Luca, primary, Wolfsgruber, Steffen, additional, Weyrauch, Anne-Sophie, additional, Zulka, Linn E., additional, Forstmeier, Simon, additional, Roeske, Sandra, additional, van den Bussche, Hendrik, additional, Kaduszkiewicz, Hanna, additional, Wiese, Birgitt, additional, Weyerer, Siegfried, additional, Werle, Jochen, additional, Fuchs, Angela, additional, Pentzek, Michael, additional, Brettschneider, Christian, additional, König, Hans-Helmut, additional, Weeg, Dagmar, additional, Bickel, Horst, additional, Luppa, Melanie, additional, Rodriguez, Francisca S., additional, Freiesleben, Silka Dawn, additional, Erdogan, Selin, additional, Unterfeld, Chantal, additional, Peters, Oliver, additional, Spruth, Eike J., additional, Altenstein, Slawek, additional, Lohse, Andrea, additional, Priller, Josef, additional, Fliessbach, Klaus, additional, Kobeleva, Xenia, additional, Schneider, Anja, additional, Bartels, Claudia, additional, Schott, Björn H., additional, Wiltfang, Jens, additional, Maier, Franziska, additional, Glanz, Wenzel, additional, Incesoy, Enise I., additional, Butryn, Michaela, additional, Düzel, Emrah, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Ewers, Michael, additional, Rauchmann, Boris-Stephan, additional, Perneczky, Robert, additional, Kilimann, Ingo, additional, Görß, Doreen, additional, Teipel, Stefan, additional, Laske, Christoph, additional, Munk, Matthias H. J., additional, Spottke, Annika, additional, Roy, Nina, additional, Brosseron, Frederic, additional, Heneka, Michael T., additional, Ramirez, Alfredo, additional, Yakupov, Renat, additional, Scherer, Martin, additional, Maier, Wolfgang, additional, Jessen, Frank, additional, Riedel-Heller, Steffi G., additional, and Wagner, Michael, additional

Published
2022
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45. A Cognitive Reserve Network That Moderates the Relationship Between Alzheimer’s Disease Pathology and Cognition

Author

Vockert, Niklas, primary, Schütze, Hartmut, additional, Richter, Anni, additional, Altenstein, Slawek, additional, Bartels, Claudia, additional, Brosseron, Frederic, additional, Cardenas‐Blanco, Arturo, additional, Dahmen, Philip, additional, Dechent, Peter, additional, Dobisch, Laura, additional, Fließbach, Klaus, additional, Freiesleben, Silka Dawn, additional, Glanz, Wenzel, additional, Goerss, Doreen, additional, Haynes, John‐Dylan, additional, Heneka, Michael T., additional, Kilimann, Ingo, additional, Kimmich, Okka, additional, Kleineidam, Luca, additional, Laske, Christoph, additional, Lohse, Andrea, additional, Metzger, Coraline D., additional, Munk, Matthias H. J., additional, Peters, Oliver, additional, Preis, Lukas, additional, Priller, Josef, additional, Ramirez, Alfredo, additional, Roeske, Sandra, additional, Rostamzadeh, Ayda, additional, Roy, Nina, additional, Scheffler, Klaus, additional, Schneider, Anja, additional, Spottke, Annika, additional, Spruth, Eike Jakob, additional, Teipel, Stefan, additional, Wagner, Michael, additional, Wiltfang, Jens, additional, Wolfsgruber, Steffen, additional, Yakupov, Renat, additional, Zeidman, Peter, additional, Jessen, Frank, additional, Schott, Björn H, additional, Duzel, Emrah, additional, Maass, Anne, additional, and Ziegler, Gabriel, additional

Published
2022
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