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32 results on '"Bartolacci, Caterina"'

2. Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Author

Bartolacci, Caterina, Andreani, Cristina, Vale, Gonçalo, Berto, Stefano, Melegari, Margherita, Crouch, Anna Colleen, Baluya, Dodge L., Kemble, George, Hodges, Kurt, Starrett, Jacqueline, Politi, Katerina, Starnes, Sandra L., Lorenzini, Daniele, Raso, Maria Gabriela, Solis Soto, Luisa M., Behrens, Carmen, Kadara, Humam, Gao, Boning, Wistuba, Ignacio I., Minna, John D., McDonald, Jeffrey G., and Scaglioni, Pier Paolo

Published
2022
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3. Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Author

Bartolacci, Caterina, Andreani, Cristina, Vale, Gonçalo, Berto, Stefano, Melegari, Margherita, Crouch, Anna Colleen, Baluya, Dodge L., Kemble, George, Hodges, Kurt, Starrett, Jacqueline, Politi, Katerina, Starnes, Sandra L., Lorenzini, Daniele, Raso, Maria Gabriela, Solis Soto, Luisa M., Behrens, Carmen, Kadara, Humam, Gao, Boning, Wistuba, Ignacio I., Minna, John D., McDonald, Jeffrey G., and Scaglioni, Pier Paolo

Published
2022
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4. Anticancer Activity of Imidazolyl Gold(I/III) Compounds in Non-Small Cell Lung Cancer Cell Lines.

Author

Galassi, Rossana, Sargentoni, Nicola, Renzi, Sofia, Luciani, Lorenzo, Bartolacci, Caterina, Pattabhi, Prasad, Andreani, Cristina, and Pucciarelli, Stefania

Subjects
NON-small-cell lung carcinoma, CANCER cell growth, TETRAHYDROFOLATE dehydrogenase, GOLD compounds, LUNG cancer
Abstract

Lung cancer is a leading cause of cancer-related death worldwide that needs updated therapies to contrast both the serious side effects and the occurrence of drug resistance. A panel of non-small cell lung cancer (NSCLC) cells were herein employed as cancer models. Eight structurally related gold(I) and gold(III) complexes with NHC and halides or triphenylphosphane ligands were investigated as lung cancer cell growth inhibitors. As expected, gold compounds with PPh3 were found to be more cytotoxic than homoleptic [(NHC)2-Au(I)]X or heteroleptic NHC-Au(I)X or NHC-Au(III)X3 complexes. Mixed ligand gold(I) compounds exhibiting the linear NHC-AuPPh3 (compound 7) or the trigonal NHC-Au(Cl)PPh3 (compound 8) arrangements at the central metal were found to be the best lung cancer cytotoxic compounds. Analysis of the TrxR residual activity of the treated cells revealed that these compounds efficiently inhibit the most accredited molecular target for gold compounds, the TrxR, with compound 8 reaching more than 80% activity reduction in lung cells. Some of the current cancer lung therapy protocols consist of specific lung cancer cell cytotoxic agents combined with antifolate drugs; interestingly, the herein gold compounds are both TrxR and antifolate inhibitors. The human DHFR was inhibited with IC50 ranging between 10–21 µM, depending on substrate concentrations, proceeding by a likely allosteric mechanism only for compound 8. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma

Author

Czyzyk-Krzeska, Maria, primary, Bischoff, Megan E, additional, Shamsaei, Behrouz, additional, Yang, Juechen, additional, Secic, Dina, additional, Vemuri, Bhargav, additional, Reisz, Julie A, additional, D'Alessandro, Angelo, additional, Bartolacci, Caterina, additional, Adamczyk, Rafal, additional, Schmidt, Lucas, additional, Wang, Jiang, additional, Martines, Amelia, additional, Biesiada, Jacek, additional, Vest, Katherine E, additional, Scaglioni, Pier Paolo, additional, Plas, David R, additional, Patra, Krushna C, additional, Gulati, Shuchi, additional, Figueroa, Julio Landero, additional, Meller, Jarek, additional, and Cunningham, J. Tom, additional

Published
2024
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8. Data from Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Author

Puca, Francesca, primary, Yu, Fei, primary, Bartolacci, Caterina, primary, Pettazzoni, Piergiorgio, primary, Carugo, Alessandro, primary, Huang-Hobbs, Emmet, primary, Liu, Jintan, primary, Zanca, Ciro, primary, Carbone, Federica, primary, Del Poggetto, Edoardo, primary, Gumin, Joy, primary, Dasgupta, Pushan, primary, Seth, Sahil, primary, Srinivasan, Sanjana, primary, Lang, Frederick F., primary, Sulman, Erik P., primary, Lorenzi, Philip L., primary, Tan, Lin, primary, Shan, Mengrou, primary, Tolstyka, Zachary P., primary, Kachman, Maureen, primary, Zhang, Li, primary, Gao, Sisi, primary, Deem, Angela K., primary, Genovese, Giannicola, primary, Scaglioni, Pier Paolo, primary, Lyssiotis, Costas A., primary, Viale, Andrea, primary, and Draetta, Giulio F., primary

Published
2023
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9. Video 1 from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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10. Supplementary S1 from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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11. Supplementary Figures from Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Author

Puca, Francesca, primary, Yu, Fei, primary, Bartolacci, Caterina, primary, Pettazzoni, Piergiorgio, primary, Carugo, Alessandro, primary, Huang-Hobbs, Emmet, primary, Liu, Jintan, primary, Zanca, Ciro, primary, Carbone, Federica, primary, Del Poggetto, Edoardo, primary, Gumin, Joy, primary, Dasgupta, Pushan, primary, Seth, Sahil, primary, Srinivasan, Sanjana, primary, Lang, Frederick F., primary, Sulman, Erik P., primary, Lorenzi, Philip L., primary, Tan, Lin, primary, Shan, Mengrou, primary, Tolstyka, Zachary P., primary, Kachman, Maureen, primary, Zhang, Li, primary, Gao, Sisi, primary, Deem, Angela K., primary, Genovese, Giannicola, primary, Scaglioni, Pier Paolo, primary, Lyssiotis, Costas A., primary, Viale, Andrea, primary, and Draetta, Giulio F., primary

Published
2023
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12. Supplementary Tables from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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13. Data from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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16. HER2-Displaying M13 Bacteriophages induce Therapeutic Immunity against Breast Cancer

Author

Wang, Junbiao, primary, Lamolinara, Alessia, additional, Conti, Laura, additional, Giangrossi, Mara, additional, Cui, Lishan, additional, Morelli, Maria Beatrice, additional, Amantini, Consuelo, additional, Falconi, Maurizio, additional, Bartolacci, Caterina, additional, Andreani, Cristina, additional, Orlando, Fiorenza, additional, Provinciali, Mauro, additional, Del Pizzo, Francesco Domenico, additional, Russo, Francesca, additional, Belletti, Barbara, additional, Riccardo, Federica, additional, Bolli, Elisabetta, additional, Quaglino, Elena, additional, Cavallo, Federica, additional, Amici, Augusto, additional, Iezzi, Manuela, additional, and Marchini, Cristina, additional

Published
2022
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20. Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Author

Puca, Francesca, primary, Yu, Fei, additional, Bartolacci, Caterina, additional, Pettazzoni, Piergiorgio, additional, Carugo, Alessandro, additional, Huang-Hobbs, Emmet, additional, Liu, Jintan, additional, Zanca, Ciro, additional, Carbone, Federica, additional, Del Poggetto, Edoardo, additional, Gumin, Joy, additional, Dasgupta, Pushan, additional, Seth, Sahil, additional, Srinivasan, Sanjana, additional, Lang, Frederick F., additional, Sulman, Erik P., additional, Lorenzi, Philip L., additional, Tan, Lin, additional, Shan, Mengrou, additional, Tolstyka, Zachary P., additional, Kachman, Maureen, additional, Zhang, Li, additional, Gao, Sisi, additional, Deem, Angela K., additional, Genovese, Giannicola, additional, Scaglioni, Pier Paolo, additional, Lyssiotis, Costas A., additional, Viale, Andrea, additional, and Draetta, Giulio F., additional

Published
2021
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21. Targetingde novolipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, additional, Vias Do Vale, Gonçalo, additional, Berto, Stefano, additional, Melegari, Margherita, additional, Crouch, Anna C., additional, Baluya, Dodge L., additional, Kemble, George, additional, Hodges, Kurt, additional, Starrett, Jacqueline, additional, Politi, Katerina, additional, Starnes, Sandra L., additional, Lorenzini, Daniele, additional, Raso, Maria Gabriela, additional, Soto, Luisa Solis, additional, Behrens, Carmen, additional, Kadara, Humam, additional, Gao, Boning, additional, Gerber, David, additional, Wistuba, Ignacio I., additional, Minna, John D., additional, McDonald, Jeffrey, additional, and Scaglioni, Pier Paolo, additional

Published
2021
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23. Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, additional, Curcio, Claudia, additional, Occhipinti, Sergio, additional, Massaccesi, Luca, additional, Giovarelli, Mirella, additional, Galeazzi, Roberta, additional, Iezzi, Manuela, additional, Tilio, Martina, additional, Gambini, Valentina, additional, Wang, Junbiao, additional, Marchini, Cristina, additional, and Amici, Augusto, additional

Published
2018
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31. Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells

Author

Francesco Cardarelli, Cristina Andreani, Valentina Gambini, Rocco Palermo, Sara Palchetti, Giulio Caracciolo, Carmine Di Rienzo, Luca Digiacomo, Daniela Pozzi, Giovanna Peruzzi, Caterina Bartolacci, Cristina Marchini, Isabella Screpanti, Heinz Amenitsch, Augusto Amici, Palchetti, Sara, Pozzi, Daniela, Marchini, Cristina, Amici, Augusto, Andreani, Cristina, Bartolacci, Caterina, Digiacomo, Luca, Gambini, Valentina, Cardarelli, Francesco, Di Rienzo, Carmine, Peruzzi, Giovanna, Amenitsch, Heinz, Palermo, Rocco, Screpanti, Isabella, and Caracciolo, Giulio

Subjects
0301 basic medicine, animal structures, viruses, Cell, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, 02 engineering and technology, Biology, Transfection, Jurkat cells, Cell transfection, Cell Line, 03 medical and health sciences, Dynamic light scattering, X-Ray Diffraction, Scattering, Small Angle, medicine, Animals, Humans, General Materials Science, Cationic liposome, Liposome, Hard-to-transfect cell, Animal, fungi, Transfection efficiency, DNA, Lipid, 021001 nanoscience & nanotechnology, Lipids, Cell biology, Lipoplexe, 030104 developmental biology, medicine.anatomical_structure, Cell culture, Lipofectamine, Cationic liposomes, Hard-to-transfect cells, Lipoplexes, Molecular Medicine, Materials Science (all), 3003, Liposomes, embryonic structures, 0210 nano-technology, Human
Abstract

To date, efficiency upon non-viral DNA delivery remains low and this implies the existence of unidentified transfection barriers. Here we explore the mechanisms of action of multicomponent (MC) cationic liposome/DNA complexes (lipoplexes) by a combination of reporter technologies, dynamic light scattering (DLS), synchrotron small angle X-ray scattering (SAXS), fluorescence activated cell sorting (FACS) analysis and laser scanning confocal microscopy (LSCM) in live cells. Lipofectamine - the gold standard among transfection reagents - was used as a reference. On the basis of our results, we suggest that an additional transfection barrier impairs transfection efficiency, that is: low lipoplex concentration at the cell surface. Based on the acquired knowledge we propose an optimized transfection protocol that allowed us to efficiently transfect DND41, JURKAT, MOLT3, P12-ICHIKAWA, ALL-SILL, TALL-1 human T-cell acute lymphoblastic leukemia (T-ALL) cell lines known to be difficult-to-transfect by using non-viral vectors and where LFN-based technologies fail to give satisfactory results.

Published
2017

32. Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma.

Author

Bischoff ME, Shamsaei B, Yang J, Secic D, Vemuri B, Reisz JA, D'Alessandro A, Bartolacci C, Adamczak R, Schmidt L, Wang J, Martines A, Venkat J, Toffessi Tcheuyap V, Biesiada J, Behrmann CA, Vest KE, Brugarolas J, Scaglioni PP, Plas DR, Patra KC, Gulati S, Landero Figueroa JA, Meller J, Cunningham JT, and Czyzyk-Krzeska MF

Abstract

Copper (Cu) is a cofactor of cytochrome c oxidase (CuCOX), indispensable for aerobic mitochondrial respiration. This study reveals that advanced clear cell renal cell carcinomas (ccRCCs) accumulate Cu, allocating it to CuCOX. Using a range of orthogonal approaches, including metabolomics, lipidomics, isotope-labeled glucose and glutamine flux analysis, and transcriptomics across tumor samples, cell lines, xenografts, and PDX models, combined with genetic and pharmacological interventions, we explored Cu's role in ccRCC. Elevated Cu levels stimulate CuCOX biogenesis, providing bioenergetic and biosynthetic benefits that promote tumor growth. This effect is complemented by glucose-dependent glutathione production, which facilitates detoxification and mitigates Cu-H2O2 toxicity. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics reveal increased oxidative metabolism, altered glutathione and Cu metabolism, and diminished HIF activity during ccRCC progression. Thus, Cu drives an integrated oncogenic remodeling of bioenergetics, biosynthesis, and redox homeostasis, fueling ccRCC growth, which can be targeted for new therapeutic approaches.

Published
2024
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