631 results on '"Bartolini, Manuela"'
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2. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease
3. Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties
4. The novel SMYD3 inhibitor EM127 impairs DNA repair response to chemotherapy-induced DNA damage and reverses cancer chemoresistance
5. Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease
6. Microsampling and enantioselective liquid chromatography coupled to mass spectrometry for chiral bioanalysis of novel psychoactive substances
7. Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3
8. Targeting neuronal calcium channels and GSK3β for Alzheimer’s disease with naturally-inspired Diels-Alder adducts
9. Novel multifunctional tacrine–donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies
10. HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy–an in vitro exploration
11. From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
12. Association Between Albumin Alterations and Renal Function in Patients With Type 2 Diabetes Mellitus
13. Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality
14. Association between Albumin Alterations and Renal Function in Patients with Type 2 Diabetes Mellitus.
15. Advanced analytical methodologies in Alzheimer’s disease drug discovery
16. Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
17. A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
18. Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
19. Unveiling the molecular mechanisms underpinning biorecognition of early-glycated human serum albumin and receptor for advanced glycation end products
20. Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
21. Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3
22. Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
23. New insights into the altered binding capacity of pharmaceutical-grade human serum albumin: site-specific binding studies by induced circular dichroism spectroscopy
24. Immobilized enzyme-based analytical tools in the -omics era: Recent advances
25. Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening
26. Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018
27. Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response: quantitative vs. qualitative assessment
28. New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation
29. Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease
30. New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents
31. Structural and functional integrity of human serum albumin: Analytical approaches and clinical relevance in patients with liver cirrhosis
32. Towards automation in protein digestion: Development of a monolithic trypsin immobilized reactor for highly efficient on-line digestion and analysis
33. Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
34. Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease
35. Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease
36. Editorial: Analytical devices based on immobilized macromolecules for structural and activity/affinity studies in drug discovery
37. Inhibition of β-Amyloid Aggregation in Alzheimer’s Disease: The Key Role of (Pro)electrophilic Warheads
38. Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease
39. 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies
40. Preface
41. The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90
42. 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
43. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
44. HSA-Binding Prodrugs-Based Nanoparticles Endowed with Chemo and Photo-Toxicity against Breast Cancer
45. Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease
46. Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers
47. Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation
48. Application of the SMALP technology to the isolation of GPCRs from low-yielding cell lines
49. Corrigendum: HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy-an in vitro exploration.
50. Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238
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