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1. Plaque assessment by coronary CT angiography may predict cardiac events in high risk and very high risk diabetic patients: A long-term follow-up study

Author: Andreini, D, Conte, E, Mushtaq, S, Magatelli, M, Traversari, F, Gigante, C, Belmonte, M, Gaudenzi-Asinelli, M, Annoni, A, Formenti, A, Mancini, M, Guglielmo, M, Baggiano, A, Melotti, E, Muscogiuri, G, Rondinelli, M, Pontone, G, Bartorelli, A, Pepi, M, Genovese, S, Andreini D, Conte E, Mushtaq S, Magatelli M, Traversari F, Gigante C, Belmonte M, Gaudenzi-Asinelli M, Annoni A, Formenti A, Mancini ME, Guglielmo M, Baggiano A, Melotti E, Muscogiuri G, Rondinelli M, Pontone G, Bartorelli AL, Pepi M, Genovese S., Andreini, D, Conte, E, Mushtaq, S, Magatelli, M, Traversari, F, Gigante, C, Belmonte, M, Gaudenzi-Asinelli, M, Annoni, A, Formenti, A, Mancini, M, Guglielmo, M, Baggiano, A, Melotti, E, Muscogiuri, G, Rondinelli, M, Pontone, G, Bartorelli, A, Pepi, M, Genovese, S, Andreini D, Conte E, Mushtaq S, Magatelli M, Traversari F, Gigante C, Belmonte M, Gaudenzi-Asinelli M, Annoni A, Formenti A, Mancini ME, Guglielmo M, Baggiano A, Melotti E, Muscogiuri G, Rondinelli M, Pontone G, Bartorelli AL, Pepi M, and Genovese S.
Abstract: Background and aims: The aim of the present study is to evaluate whether advanced coronary atherosclerosis analysis by CCTA may improve prognostic stratification among diabetic patients at high cardiovascular risk (CV risk). Methods and results: The study population consisted of 265 consecutive diabetic patients at high CV risk who underwent CCTA for suspected CAD between January 2011 and December 2016. For every patients both traditional and advanced, qualitative and quantitative coronary plaque analysis were performed. The occurrence of cardiac death, ACS, and non-urgent revascularization were recorded at follow-up. Among the 265 patients enrolled, 21 were lost to follow-up, whereas 244 (92%) had a complete follow-up (mean 45 ± 22 months) and were classified at high (n = 67) or very high cardiovascular risk (n = 177), according to ESC Guidelines. A total of 63 events were recorded (3 Cardiac Death, 3 NSTEMI, 8 unstable angina, 36 late non-urgent revascularization and 13 non-cardiac death) in 57 different patients. Elevated fibro-fatty plaque volume was the only predictor of events over age, gender and traditional risk factor when ACS and MACE were considered as end-points [HR (95% CI) 6.01 (1.65–21.87), p = 0.006 and 3.46 (2.00–5.97); p < 0.001]. Conclusion: The present study confirms the prognostic role of advance coronary atherosclerosis evaluation beyond risk factors and stenosis severity, even in diabetics. Despite the very high cardiovascular risk of study population, a not negligible portion (23%) of patients exhibited totally normal coronaries.
Published: 2022

2. European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic : part 1: epidemiology, pathophysiology, and diagnosis The Task Force for the management of COVID-19 of the European Society of Cardiology

Author: Baigent, C, Windecker, S, Andreini, D, Arbelo, E, Barbato, E, Bartorelli, AL, Baumbach, A, Behr, ER, Berti, S, Bueno, H, Capodanno, D, Cappato, R, Chieffo, A, Collet, JP, Cuisset, T, de Simone, G, Delgado, V, Dendale, P, Dudek, D, Edvardsen, T, Elvan, A, Gonzalez-Juanatey, JR, Gori, M, Grobbee, D, Guzik, TJ, Halvorsen, S, Haude, M, Heidbuchel, H, Hindricks, G, Ibanez, B, Karam, N, Katus, H, Klok, FA, Konstantinides, SV, Landmesser, U, Leclercq, C, Leonardi, S, Lettino, M, Marenzi, G, Mauri, J, Metra, M, Morici, N, Mueller, C, Petronio, AS, Polovina, MM, Potpara, T, Praz, F, Prendergast, B, Prescott, E, Price, S, Pruszczyk, P, Rodriguez-Leor, O, Roffi, M, Romaguera, R, Rosenkranz, S, Sarkozy, A, Scherrenberg, M, Seferovic, P, Senni, M, Spera, FR, Stefanini, G, Thiele, H, Tomasoni, D, Torracca, L, Touyz, RM, Wilde, AA, Williams, B, and Task Force for the management of COVID-19 of the European Society of Cardiology
Subjects: Myocarditis, Myocardial injury, Non-invasive imaging, ACE2, COVID-19, Human medicine, Arrhythmias, Cardiogenic shock, Biomarkers
Abstract: Aims Since its emergence in early 2020, the novel severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019 (COVID-19) has reached pandemic levels, and there have been repeated outbreaks across the globe. The aim of this two-part series is to provide practical knowledge and guidance to aid clinicians in the diagnosis and management of cardiovascular disease (CVD) in association with COVID-19. Methods and results A narrative literature review of the available evidence has been performed, and the resulting information has been organized into two parts. The first, reported here, focuses on the epidemiology, pathophysiology, and diagnosis of cardiovascular (CV) conditions that may be manifest in patients with COVID-19. The second part, which will follow in a later edition of the journal, addresses the topics of care pathways, treatment, and follow-up of CV conditions in patients with COVID-19. Conclusion This comprehensive review is not a formal guideline but rather a document that provides a summary of current knowledge and guidance to practicing clinicians managing patients with CVD and COVID-19. The recommendations are mainly the result of observations and personal experience from healthcare providers. Therefore, the information provided here may be subject to change with increasing knowledge, evidence from prospective studies, and changes in the pandemic. Likewise, the guidance provided in the document should not interfere with recommendations provided by local and national healthcare authorities. [GRAPHICS] .
Published: 2022

3. Site vs. core laboratory variability in computed tomographic angiography-derived SYNTAX scores in the SYNTAX III trial

Author: Katagiri Y, Andreini D, Miyazaki Y, Takahashi K, Komiyama H, Mushtaq S, Sonck J, Schoors D, Maisano F, Kaufman PA, Leal I, Lindeboom W, Piek JJ, Wykrzykowska JJ, Morel MA, Bartorelli AL, Onuma Y, Serruys PW, Katagiri, Y, Andreini, D, Miyazaki, Y, Takahashi, K, Komiyama, H, Mushtaq, S, Sonck, J, Schoors, D, Maisano, F, Kaufman, Pa, Leal, I, Lindeboom, W, Piek, Jj, Wykrzykowska, Jj, Morel, Ma, Bartorelli, Al, Onuma, Y, and Serruys, Pw
Published: 2020

4. MODERATED POSTER SESSION: Imaging in interventional cardiology: Wednesday 3 December 2014, 09: 00–16: 00Location: Moderated Poster area

Author: Muratori, M, Fusini, L, Gripari, P, Tamborini, G, Ghulam Ali, S, Salvi, L, Bartorelli, AL, Agrifoglio, M, Alamanni, F, and Pepi, M
Published: 2014

5. Poster session Thursday 12 December - AM: 12/12/2013, 08: 30–12: 30Location: Poster area

Author: Maffessanti, F, Gripari, P, Tamborini, G, Muratori, M, Fusini, L, Ferrari, C, Caiani, EG, Alamanni, F, Bartorelli, AL, and Pepi, M
Published: 2013

6. Poster session Wednesday 11 December all day display: 11/12/2013, 09: 30–16: 00Location: Poster area

Author: Gripari, P, Maffessanti, F, Tamborini, G, Muratori, M, Fusini, L, Vignati, C, Bartorelli, AL, Alamanni, F, Agostoni, PG, and Pepi, M
Published: 2013

7. Sequential Strategy Including FFR CT Plus Stress-CTP Impacts on Management of Patients with Stable Chest Pain: The Stress-CTP RIPCORD Study

Author: Baggiano, A, Fusini, L, Del Torto, A, Vivona, P, Guglielmo, M, Muscogiuri, G, Soldi, M, Martini, C, Fraschini, E, Rabbat, M, Baessato, F, Cicala, G, Danza, M, Cavaliere, A, Loffreno, A, Palmisano, V, Ricci, F, Rizzon, G, Tonet, E, Viani, G, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, M, Fabbiocchi, F, Montorsi, P, Trabattoni, D, Rossi, A, Fazzari, F, Gaibazzi, N, Andreini, D, Assanelli, E, Bartorelli, A, Pepi, M, Guaricci, A, Pontone, G, Baggiano A, Fusini L, Del Torto A, Vivona P, Guglielmo M, Muscogiuri G, Soldi M, Martini C, Fraschini E, Rabbat MG, Baessato F, Cicala G, Danza ML, Cavaliere A, Loffreno A, Palmisano V, Ricci F, Rizzon G, Tonet E, Viani GM, Mushtaq S, Conte E, Annoni AD, Formenti A, Mancini ME, Fabbiocchi F, Montorsi P, Trabattoni D, Rossi A, Fazzari F, Gaibazzi N, Andreini D, Assanelli EM, Bartorelli AL, Pepi M, Guaricci AI, Pontone G, Baggiano, A, Fusini, L, Del Torto, A, Vivona, P, Guglielmo, M, Muscogiuri, G, Soldi, M, Martini, C, Fraschini, E, Rabbat, M, Baessato, F, Cicala, G, Danza, M, Cavaliere, A, Loffreno, A, Palmisano, V, Ricci, F, Rizzon, G, Tonet, E, Viani, G, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, M, Fabbiocchi, F, Montorsi, P, Trabattoni, D, Rossi, A, Fazzari, F, Gaibazzi, N, Andreini, D, Assanelli, E, Bartorelli, A, Pepi, M, Guaricci, A, Pontone, G, Baggiano A, Fusini L, Del Torto A, Vivona P, Guglielmo M, Muscogiuri G, Soldi M, Martini C, Fraschini E, Rabbat MG, Baessato F, Cicala G, Danza ML, Cavaliere A, Loffreno A, Palmisano V, Ricci F, Rizzon G, Tonet E, Viani GM, Mushtaq S, Conte E, Annoni AD, Formenti A, Mancini ME, Fabbiocchi F, Montorsi P, Trabattoni D, Rossi A, Fazzari F, Gaibazzi N, Andreini D, Assanelli EM, Bartorelli AL, Pepi M, Guaricci AI, and Pontone G
Abstract: Stress computed tomography perfusion (Stress-CTP) and computed tomography-derived fractional flow reserve (FFRCT) are functional techniques that can be added to coronary computed tomography angiography (cCTA) to improve the management of patients with suspected coronary artery disease (CAD). This retrospective analysis from the PERFECTION study aims to assess the impact of their availability on the management of patients with suspected CAD scheduled for invasive coronary angiography (ICA) and invasive FFR. The management plan was defined as optimal medical therapy (OMT) or revascularization and was recorded for the following strategies: cCTA alone, cCTA+FFRCT, cCTA+Stress-CTP and cCTA+FFRCT+Stress-CTP. In 291 prospectively enrolled patients, cCTA+FFRCT, cCTA+Stress-CTP and cCTA+FFRCT+Stress-CTP showed a similar rate of reclassification of cCTA findings when FFRCT and Stress-CTP were added to cCTA. cCTA, cCTA+FFRCT, cCTA+Stress-CTP and cCTA+FFRCT+Stress-CTP showed a rate of agreement versus the final therapeutic decision of 63%, 71%, 89%, 84% (cCTA+Stress-CTP and cCTA+FFRCT+Stress-CTP vs cCTA and cCTA+FFRCT: p < 0.01), respectively, and a rate of agreement in terms of the vessels to be revascularized of 57%, 64%, 74%, 71% (cCTA+Stress-CTP and cCTA+FFRCT+Stress-CTP vs cCTA and cCTA+FFRCT: p < 0.01), respectively, with an effective radiation dose (ED) of 2.9 ± 1.3 mSv, 2.9 ± 1.3 mSv, 5.9 ± 2.7 mSv, and 3.1 ± 2.1 mSv. The addition of FFRCT and Stress-CTP improved therapeutic decision-making compared to cCTA alone, and a sequential strategy with cCTA+FFRCT+Stress-CTP represents the best compromise in terms of clinical impact and radiation exposure.
Published: 2020

8. Interpretability of Coronary CT Angiography Performed With a Novel Whole-Heart Coverage High-Definition CT Scanner in 300 Consecutive Patients With Coronary Artery Bypass Grafts

Author: Mushtaq, S, Conte, E, Pontone, G, Pompilio, G, Guglielmo, M, Annoni, A, Baggiano, A, Formenti, A, Mancini, M, Muscogiuri, G, Nicoli, F, Giannitto, C, Magatelli, M, Tanzilli, A, Consiglio, E, Fiorentini, C, Bartorelli, A, Pirillo, S, Pepi, M, Andreini, D, Mushtaq S, Conte E, Pontone G, Pompilio G, Guglielmo M, Annoni A, Baggiano A, Formenti A, Mancini ME, Muscogiuri G, Nicoli F, Giannitto C, Magatelli M, Tanzilli A, Consiglio E, Fiorentini C, Bartorelli AL, Pirillo SP, Pepi M, Andreini D, Mushtaq, S, Conte, E, Pontone, G, Pompilio, G, Guglielmo, M, Annoni, A, Baggiano, A, Formenti, A, Mancini, M, Muscogiuri, G, Nicoli, F, Giannitto, C, Magatelli, M, Tanzilli, A, Consiglio, E, Fiorentini, C, Bartorelli, A, Pirillo, S, Pepi, M, Andreini, D, Mushtaq S, Conte E, Pontone G, Pompilio G, Guglielmo M, Annoni A, Baggiano A, Formenti A, Mancini ME, Muscogiuri G, Nicoli F, Giannitto C, Magatelli M, Tanzilli A, Consiglio E, Fiorentini C, Bartorelli AL, Pirillo SP, Pepi M, and Andreini D
Abstract: Aims: Coronary CT angiography (CCTA) is an accurate non-invasive tool for the evaluation of coronary artery bypass graft (CABG). However, inability to sustain a long breath-hold, high heart rate (HR) and atrial fibrillation may affect image quality. Moreover, radiation exposure is still a matter of some concern. A scanner combining 0.23-mm spatial resolution, new iterative reconstruction and fast gantry rotation time has been recently introduced in the clinical field. The aims of our study were to evaluate interpretability, radiation exposure and diagnostic accuracy of CCTA performed with the latest generation of cardiac-CT scanners compared to invasive coronary angiography (ICA) in the assessment of bypass grafts, and non-grafted and post-anastomotic native coronary arteries. Methods and results: We prospectively enrolled 300 patients undergoing clinically indicated CCTA with a 16-cm z-axis coverage, 256-detector rows, and 0.28-sec gantry rotation time scanner. Coronary artery and graft interpretability, image quality and effective dose (ED) were assessed in all patients and diagnostic accuracy was evaluated in a subgroup of 100 patients who underwent ICA. Mean HR during the scan was 69.6 ± 10.8. Sinus rhythm was present in 118 patients with HR < 75 bpm and in 112 patients with HR ≥ 75 bpm, while 70 patients had atrial fibrillation. CABG interpretability was 100%. Compared to ICA, CCTA was able to correctly detecting occlusions or significant stenoses of all CABG segments. Overall interpretability of native coronary segments was 95.6%. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of coronary arteries were 98.3%, 97.4%, 93.1%, 99.3% and 96.5%, respectively. The diagnostic accuracy in a patient based analysis was 95.2%. Mean ED was 3.14 ± 1.7 mSv. Conclusions: The novel whole-heart coverage CT scanner allows to evaluating CABG and native coronary arteries with excellent interpretability and low radiation exposure even
Published: 2020

9. CT Perfusion Versus Coronary CT Angiography in Patients With Suspected In-Stent Restenosis or CAD Progression

Author: Andreini, D, Mushtaq, S, Pontone, G, Conte, E, Collet, C, Sonck, J, D'Errico, A, Di Odoardo, L, Guglielmo, M, Baggiano, A, Trabattoni, D, Ravagnani, P, Montorsi, P, Teruzzi, G, Olivares, P, Fabbiocchi, F, De Martini, S, Calligaris, G, Annoni, A, Mancini, M, Formenti, A, Magatelli, M, Consiglio, E, Muscogiuri, G, Lombardi, F, Fiorentini, C, Bartorelli, A, Pepi, M, De Martini S, Mancini, ME, Bartorelli, AL, Andreini, D, Mushtaq, S, Pontone, G, Conte, E, Collet, C, Sonck, J, D'Errico, A, Di Odoardo, L, Guglielmo, M, Baggiano, A, Trabattoni, D, Ravagnani, P, Montorsi, P, Teruzzi, G, Olivares, P, Fabbiocchi, F, De Martini, S, Calligaris, G, Annoni, A, Mancini, M, Formenti, A, Magatelli, M, Consiglio, E, Muscogiuri, G, Lombardi, F, Fiorentini, C, Bartorelli, A, Pepi, M, De Martini S, Mancini, ME, and Bartorelli, AL
Abstract: Objectives: The goal of this study was to assess the diagnostic performance of coronary computed tomography angiography (CTA) alone, adenosine-stress myocardial perfusion assessed by computed tomography (CTP) alone, and coronary CTA + CTP by using a 16-cm Z-axis coverage scanner versus invasive coronary angiography (ICA) and fractional flow reserve (FFR) as the clinical standard. Background: Diagnostic performance of coronary CTA for in-stent restenosis detection is still challenging. Recently, CTP showed additional diagnostic power over coronary CTA in patients with suspected coronary artery disease. However, few data are available on CTP performance in patients with previous stent implantation. Methods: Consecutive stable patients with previous coronary stenting referred for ICA were enrolled. All patients underwent stress myocardial CTP and rest CTP + coronary CTA. Invasive FFR was performed during ICA when clinically indicated. The diagnostic rate and diagnostic accuracy of coronary CTA, CTP, and coronary CTA + CTP were evaluated in stent-, territory-, and patient-based analyses. Results: In the 150 enrolled patients (132 men; mean age 65.1 ± 9.1 years), the CTP diagnostic rate was significantly higher than that of coronary CTA in all analyses (territory based [96.7% vs. 91.1%; p < 0.0001] and patient based [96% vs. 68%; p < 0.0001]). When ICA was used as gold standard, CTP diagnostic accuracy was significantly higher than that of coronary CTA in all analyses (territory based [92.1% vs. 85.5%, p < 0.03] and patient based [86.7% vs. 76.7%, p < 0.03]). The concordant coronary CTA + CTP assessment exhibited the highest diagnostic accuracy values versus ICA (95.8% in the territory-based analysis). The diagnostic accuracy of CTP was significantly higher than that of coronary CTA (75% vs. 30.5%; p < 0.001). The radiation exposure of coronary CTA + CTP was 4.15 ± 1.5 mSv. Conclusions: In patients with coronary stents, CTP significantly improved the diagn
Published: 2020

10. The usefulness of cardiac CT integrated with FFRCT for planning myocardial revascularization in complex coronary artery disease: A lesson from SYNTAX studies

Author: Andreini, D, Mushtaq, S, Conte, E, Mei, M, Nicoli, F, Melotti, E, Pompilio, G, Pepi, M, Bartorelli, AL, Onuma, Yoshinobu, Serruys, PWJC (Patrick), Andreini, D, Mushtaq, S, Conte, E, Mei, M, Nicoli, F, Melotti, E, Pompilio, G, Pepi, M, Bartorelli, AL, Onuma, Yoshinobu, and Serruys, PWJC (Patrick)
Published: 2020

11. Resources and outcome impact of routine availability of computed tomography perfusion

Author: Baggiano, A, primary, Del Torto, A, additional, Fusini, L, additional, Guglielmo, M, additional, Muscogiuri, G, additional, Andreini, D, additional, Mushtaq, S, additional, Conte, E, additional, Annoni, AD, additional, Formenti, A, additional, Mancini, ME, additional, Guaricci, AI, additional, Bartorelli, AL, additional, Pepi, M, additional, and Pontone, G, additional
Published: 2021
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12. Prosthesis-patient mismatch after aortic valve in valve procedure: incidence, predictors and clinical outcomes

Author: Fusini, L, primary, Muratori, M, additional, Ghulam Ali, S, additional, Gripari, P, additional, Cefalu", C, additional, Junod, D, additional, Fabbiocchi, F, additional, Roberto, M, additional, Trabattoni, P, additional, Agrifoglio, M, additional, Bartorelli, AL, additional, Alamanni, F, additional, Pepi, M, additional, and Tamborini, G, additional
Published: 2021
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13. Association Between Haptoglobin Phenotype and Microvascular Obstruction in Patients With ST-Segment Elevation Myocardial Infarction

Author: Pontone G, Andreini D, Guaricci AI, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Fazzari F, Berzovini C, Pasquini A, Mushtaq S, Conte E, Cosentino N, Rabbat MG, Marenzi G, Bartorelli AL, Pepi M, Tremoli E, Banfi C., Pontone, G, Andreini, D, Guaricci, A, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Fazzari, F, Berzovini, C, Pasquini, A, Mushtaq, S, Conte, E, Cosentino, N, Rabbat, M, Marenzi, G, Bartorelli, A, Pepi, M, Tremoli, E, and Banfi, C
Subjects: myocardial infarction, microvascular obstruction, cardiac magnetic resonance, haptoglobin
Abstract: Objectives: This study aimed to evaluate the correlation between different haptoglobin (Hp)phenotypes and myocardial infarction characteristics as detected by cardiac magnetic resonance (CMR)in consecutive patients after ST-segment elevation myocardial infarction (STEMI). Background: Hp is a plasma protein that prevents iron-mediated oxidative tissue damage. CMR has emerged as the gold standard technique to detect left ventricular ejection fraction (LVEF), extent of scar with late gadolinium enhancement (LGE)technique, microvascular obstruction (MVO), and myocardial hemorrhage (MH)in patients with STEMI treated by primary percutaneous coronary intervention (pPCI). Methods: A total of 145 consecutive STEMI patients (mean age 62.2 ± 10.3 years; 78% men)were prospectively enrolled and underwent Hp phenotyping and CMR assessment within 1 week after STEMI. Results: CMR showed an area at risk (AAR)involving 26.6 ± 19.1% of left ventricular (LV)mass with a late LGE extent of 15.2 ± 13.1% of LV mass. MVO and MH occurred in 38 (26%)and 12 (8%)patients, respectively. Hp phenotypes 1-1, 2-1, 2-2 were observed in 15 (10%), 62 (43%), and 68 (47%), respectively. Multivariable analysis demonstrated that body mass index, Hp2-2, diabetes, and peak troponin I were independent predictors of MVO with Hp2-2 associated with the highest odds ratio (OR)(OR: 5.5 [95% confidence interval [CI]: 2.1 to 14.3; p < 0.001]). Hp2-2 significantly predicted both the presence (area under the curve [AUC]: 0.63 [95% CI: 0.53 to 0.72; p = 0.008])and extent of MVO (AUC: 0.63 [95% CI: 0.54 to 0.72; p = 0.007]). Conclusions: Hp phenotype is an independent predictor of MVO. Therefore, Hp phenotyping could be used for risk stratification and may be useful in assessing new therapies to reduce myocardial reperfusion injury in patients with STEMI.
Published: 2019

14. Stress Computed Tomography Perfusion Versus Fractional Flow Reserve CT Derived in Suspected Coronary Artery Disease: The PERFECTION Study

Author: Pontone G, Baggiano A, Andreini D, Guaricci AI, Guglielmo M, Muscogiuri G, Fusini L, Fazzari F, Mushtaq S, Conte E, Calligaris G, De Martini S, Ferrari C, Galli S, Grancini L, Ravagnani P, Teruzzi G, Trabattoni D, Fabbiocchi F, Lualdi A, Montorsi P, Rabbat MG, Bartorelli AL, Pepi M, Pontone, G, Baggiano, A, Andreini, D, Guaricci, A, Guglielmo, M, Muscogiuri, G, Fusini, L, Fazzari, F, Mushtaq, S, Conte, E, Calligaris, G, De Martini, S, Ferrari, C, Galli, S, Grancini, L, Ravagnani, P, Teruzzi, G, Trabattoni, D, Fabbiocchi, F, Lualdi, A, Montorsi, P, Rabbat, M, Bartorelli, A, and Pepi, M
Subjects: accuracy, computed tomography, fractional flow reserve, coronary artery disease, perfusion
Abstract: Objectives: This study sought to compare the diagnostic accuracy of coronary computed tomography angiography (cCTA) with that of cCTA+fractional flow reserve derived from cCTA datasets (FFRCT) and that of cCTA+static stress-computed tomography perfusion (stress-CTP) in detecting functionally significant coronary artery lesions using invasive coronary angiography (ICA) plus invasive FFR as the reference standard. Background: FFRCT and static stress-CTP are new techniques that combine anatomy and functional evaluation to improve assessment of coronary artery disease (CAD) using cCTA. Methods: A total of 147 consecutive symptomatic patients scheduled for clinically indicated ICA+invasive FFR were evaluated with cCTA, FFRCT, and stress-CTP. Results: Vessel-based and patient-based sensitivity, specificity, and negative predictive values, and positive predictive values, and accuracy rates of cCTA were 99%, 76%, 100%, 61%, 82%, and 95%, 54%, 94%, 63%, 73%, respectively. cCTA+FFRCT showed vessel-based and patient-based sensitivity, specificity, and negative predictive values, and positive predictive values and accuracy rates of 88%, 94%, 95%, 84%, 92%, and 90%, 85%, 92%, 83%, 87%, respectively. Finally, cCTA+stress-CTP showed vessel-based and patient-based sensitivity, specificity, and negative predictive values, and positive predictive values and accuracy rates of 92%, 95%, 97%, 87%, 94% and 98%, 87%, 99%, 86%, 92%, respectively. Both FFRCT and stress-CTP significantly improved specificity and positive predictive values compared to those of cCTA alone. The area under the curve to detect flow-limiting stenoses of cCTA, cCTA+FFRCT, and cCTA+CTP were 0.89, 0.93, 0.92, and 0.90, 0.94, and 0.93 in a vessel-based and patient-based model, respectively, with significant additional values for both cCTA+FFRCT and cCTA+CTP versus cCTA alone (p < 0.001) but no differences between cCTA+FFRCT versus cCTA+CTP. Conclusions: FFRCT and stress-CTP in addition to cCTA are valid and comparable tools to evaluate the functional relevance of CAD.
Published: 2019

15. Three-year clinical outcomes of patients treated with everolimus-eluting bioresorbable vascular scaffolds: Final results of the ABSORB EXTEND trial

Author: Costa, JR, Abizaid, A, Whitbourn, R, Serruys, PWJC (Patrick), Jepson, N, Steinwender, C, Stuteville, M, Ediebah, D, Sudhir, K, Bartorelli, AL, and Cardiology
Published: 2019

16. Stress Computed Tomography Perfusion Versus Fractional Flow Reserve CT Derived in Suspected Coronary Artery Disease: The PERFECTION Study

Author: Pontone, G, Baggiano, A, Andreini, D, Guaricci, A, Guglielmo, M, Muscogiuri, G, Fusini, L, Fazzari, F, Mushtaq, S, Conte, E, Calligaris, G, De Martini, S, Ferrari, C, Galli, S, Grancini, L, Ravagnani, P, Teruzzi, G, Trabattoni, D, Fabbiocchi, F, Lualdi, A, Montorsi, P, Rabbat, M, Bartorelli, A, Pepi, M, Pontone G, Baggiano A, Andreini D, Guaricci AI, Guglielmo M, Muscogiuri G, Fusini L, Fazzari F, Mushtaq S, Conte E, Calligaris G, De Martini S, Ferrari C, Galli S, Grancini L, Ravagnani P, Teruzzi G, Trabattoni D, Fabbiocchi F, Lualdi A, Montorsi P, Rabbat MG, Bartorelli AL, Pepi M, Pontone, G, Baggiano, A, Andreini, D, Guaricci, A, Guglielmo, M, Muscogiuri, G, Fusini, L, Fazzari, F, Mushtaq, S, Conte, E, Calligaris, G, De Martini, S, Ferrari, C, Galli, S, Grancini, L, Ravagnani, P, Teruzzi, G, Trabattoni, D, Fabbiocchi, F, Lualdi, A, Montorsi, P, Rabbat, M, Bartorelli, A, Pepi, M, Pontone G, Baggiano A, Andreini D, Guaricci AI, Guglielmo M, Muscogiuri G, Fusini L, Fazzari F, Mushtaq S, Conte E, Calligaris G, De Martini S, Ferrari C, Galli S, Grancini L, Ravagnani P, Teruzzi G, Trabattoni D, Fabbiocchi F, Lualdi A, Montorsi P, Rabbat MG, Bartorelli AL, and Pepi M
Abstract: Objectives: This study sought to compare the diagnostic accuracy of coronary computed tomography angiography (cCTA) with that of cCTA+fractional flow reserve derived from cCTA datasets (FFRCT) and that of cCTA+static stress-computed tomography perfusion (stress-CTP) in detecting functionally significant coronary artery lesions using invasive coronary angiography (ICA) plus invasive FFR as the reference standard. Background: FFRCT and static stress-CTP are new techniques that combine anatomy and functional evaluation to improve assessment of coronary artery disease (CAD) using cCTA. Methods: A total of 147 consecutive symptomatic patients scheduled for clinically indicated ICA+invasive FFR were evaluated with cCTA, FFRCT, and stress-CTP. Results: Vessel-based and patient-based sensitivity, specificity, and negative predictive values, and positive predictive values, and accuracy rates of cCTA were 99%, 76%, 100%, 61%, 82%, and 95%, 54%, 94%, 63%, 73%, respectively. cCTA+FFRCT showed vessel-based and patient-based sensitivity, specificity, and negative predictive values, and positive predictive values and accuracy rates of 88%, 94%, 95%, 84%, 92%, and 90%, 85%, 92%, 83%, 87%, respectively. Finally, cCTA+stress-CTP showed vessel-based and patient-based sensitivity, specificity, and negative predictive values, and positive predictive values and accuracy rates of 92%, 95%, 97%, 87%, 94% and 98%, 87%, 99%, 86%, 92%, respectively. Both FFRCT and stress-CTP significantly improved specificity and positive predictive values compared to those of cCTA alone. The area under the curve to detect flow-limiting stenoses of cCTA, cCTA+FFRCT, and cCTA+CTP were 0.89, 0.93, 0.92, and 0.90, 0.94, and 0.93 in a vessel-based and patient-based model, respectively, with significant additional values for both cCTA+FFRCT and cCTA+CTP versus cCTA alone (p < 0.001) but no differences between cCTA+FFRCT versus cCTA+CTP. Conclusions: FFRCT and stress-CTP in addition to cCTA are valid and compara
Published: 2019

17. Association Between Haptoglobin Phenotype and Microvascular Obstruction in Patients With ST-Segment Elevation Myocardial Infarction

Author: Pontone, G, Andreini, D, Guaricci, A, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Fazzari, F, Berzovini, C, Pasquini, A, Mushtaq, S, Conte, E, Cosentino, N, Rabbat, M, Marenzi, G, Bartorelli, A, Pepi, M, Tremoli, E, Banfi, C, Pontone G, Andreini D, Guaricci AI, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Fazzari F, Berzovini C, Pasquini A, Mushtaq S, Conte E, Cosentino N, Rabbat MG, Marenzi G, Bartorelli AL, Pepi M, Tremoli E, Banfi C., Pontone, G, Andreini, D, Guaricci, A, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Fazzari, F, Berzovini, C, Pasquini, A, Mushtaq, S, Conte, E, Cosentino, N, Rabbat, M, Marenzi, G, Bartorelli, A, Pepi, M, Tremoli, E, Banfi, C, Pontone G, Andreini D, Guaricci AI, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Fazzari F, Berzovini C, Pasquini A, Mushtaq S, Conte E, Cosentino N, Rabbat MG, Marenzi G, Bartorelli AL, Pepi M, Tremoli E, and Banfi C.
Abstract: Objectives: This study aimed to evaluate the correlation between different haptoglobin (Hp)phenotypes and myocardial infarction characteristics as detected by cardiac magnetic resonance (CMR)in consecutive patients after ST-segment elevation myocardial infarction (STEMI). Background: Hp is a plasma protein that prevents iron-mediated oxidative tissue damage. CMR has emerged as the gold standard technique to detect left ventricular ejection fraction (LVEF), extent of scar with late gadolinium enhancement (LGE)technique, microvascular obstruction (MVO), and myocardial hemorrhage (MH)in patients with STEMI treated by primary percutaneous coronary intervention (pPCI). Methods: A total of 145 consecutive STEMI patients (mean age 62.2 ± 10.3 years; 78% men)were prospectively enrolled and underwent Hp phenotyping and CMR assessment within 1 week after STEMI. Results: CMR showed an area at risk (AAR)involving 26.6 ± 19.1% of left ventricular (LV)mass with a late LGE extent of 15.2 ± 13.1% of LV mass. MVO and MH occurred in 38 (26%)and 12 (8%)patients, respectively. Hp phenotypes 1-1, 2-1, 2-2 were observed in 15 (10%), 62 (43%), and 68 (47%), respectively. Multivariable analysis demonstrated that body mass index, Hp2-2, diabetes, and peak troponin I were independent predictors of MVO with Hp2-2 associated with the highest odds ratio (OR)(OR: 5.5 [95% confidence interval [CI]: 2.1 to 14.3; p < 0.001]). Hp2-2 significantly predicted both the presence (area under the curve [AUC]: 0.63 [95% CI: 0.53 to 0.72; p = 0.008])and extent of MVO (AUC: 0.63 [95% CI: 0.54 to 0.72; p = 0.007]). Conclusions: Hp phenotype is an independent predictor of MVO. Therefore, Hp phenotyping could be used for risk stratification and may be useful in assessing new therapies to reduce myocardial reperfusion injury in patients with STEMI.
Published: 2019

18. Three-year clinical outcomes of patients treated with everolimus-eluting bioresorbable vascular scaffolds: Final results of the ABSORB EXTEND trial

Author: Ribamar Costa, J, Abizaid, A, Whitbourn, R, Serruys, PW, Jepson, N, Steinwender, C, Stuteville, M, Ediebah, D, Sudhir, K, Bartorelli, AL, Ribamar Costa, J, Abizaid, A, Whitbourn, R, Serruys, PW, Jepson, N, Steinwender, C, Stuteville, M, Ediebah, D, Sudhir, K, and Bartorelli, AL
Abstract: BACKGROUND: There is still limited data on the very long term clinical outcomes after ABSORB BRS in daily practice. We sought to evaluate the 3 year-performance of the Absorb bioresorbable vascular scaffolds for the treatment of low/moderate complexity patients enrolled in the ABSORB EXTEND trial. METHODS: ABSORB EXTEND is a prospective, single-arm, open-label clinical study in which 812 patients were enrolled at 56 sites. This study allowed the treatment of lesions ≤28 mm in length and reference vessel diameter of 2.0-3.8 mm (as assessed by on-line QCA). To determine the independent predictors of MACE, a multivariable logistic regression model was built using a stepwise (forward/backward) procedure. RESULTS: Average population age was 61 years and 26.5% had diabetes. Most patients had single target lesion (92.4%). Adequate scaffold deployment (PSP) was achieved in 14.2% of the cases. At three years, the composite endpoints of MACE and ischemia-driven target vessel failure were 9.2% and 10.6%, respectively. The cumulative rate of ARC definite/probable thrombosis was 2.2%, with 1.2% of the cases occurring after the 1st year. Independent predictors of MACE were hypertension and the need for "bail out" stent. CONCLUSION: At three-year follow-up, the use of ABSORB in low/moderate complex PCI was associated with low and acceptable rates of major adverse clinical events, despite the infrequent use of the recommended contemporary scaffold deployment technique. However, scaffold thrombosis rate was higher than reported with current generation of metallic DES. The study is registered on clinicaltrials.gov (unique identifier NCT01023789).
Published: 2019

19. Low-Dose Coronary CT Angiography in Patients with Atrial Fibrillation: Comparison of Image Quality and Radiation Exposure with Two Different Approaches

Author: Mushtaq, S, Pontone, G, Conte, E, Guglielmo, M, Consiglio, E, Magatelli, M, Oliveira, M, Muscogiuri, G, Annoni, A, Baggiano, A, Formenti, A, Mancini, M, Di Odoardo, L, Melotti, E, Fiorentini, C, Bartorelli, A, Pepi, M, Andreini, D, Mushtaq S, Pontone G, Conte E, Guglielmo M, Consiglio E, Magatelli M, Oliveira M, Muscogiuri G, Annoni A, Baggiano A, Formenti A, Mancini ME, Di Odoardo L, Melotti E, Fiorentini C, Bartorelli AL, Pepi M, Andreini D., Mushtaq, S, Pontone, G, Conte, E, Guglielmo, M, Consiglio, E, Magatelli, M, Oliveira, M, Muscogiuri, G, Annoni, A, Baggiano, A, Formenti, A, Mancini, M, Di Odoardo, L, Melotti, E, Fiorentini, C, Bartorelli, A, Pepi, M, Andreini, D, Mushtaq S, Pontone G, Conte E, Guglielmo M, Consiglio E, Magatelli M, Oliveira M, Muscogiuri G, Annoni A, Baggiano A, Formenti A, Mancini ME, Di Odoardo L, Melotti E, Fiorentini C, Bartorelli AL, Pepi M, and Andreini D.
Abstract: Rationale and Objectives: To evaluate image quality, coronary interpretability and radiation exposure of coronary CT angiography (CCTA)performed in patients with atrial fibrillation (AF)with the latest scanner generation, comparing two different technical approaches. A new scanner that combines a 0.23 mm spatial resolution, a new generation of iterative reconstruction, fast gantry rotation time and the intracycle motion-correction algorithm to improve the temporal resolution was recently introduced in the clinical field. Materials and Methods: We enrolled 105 consecutive patients with chronic AF who performed CCTA with a whole-heart coverage high-definition CT scanner (16-cm z-axis coverage with 256 detector rows, 0.28 s gantry rotation time). Five of them were excluded for impaired renal function. Patients were randomized between a double acquisition protocol (50 patients, group 1)or a single acquisition protocol (50 patients, group 2). The image quality, coronary segment interpretability and effective dose (ED)of CCTA were assessed. Results: The mean HR during the scan was 85.6±21 bpm in group 1 vs. 83.7±23 bpm in Group 2, respectively (p < ns). In group 2, overall image quality was high and comparable with that of group 1 (Likert scale =3.2 ± 1.4 vs. 3.3 ± 1.2, p = ns, in group 1 and 2, respectively). Coronary interpretability was high and similar between the two groups (97.5% and 97.1% in group 1 and 2, p = ns, respectively). Mean ED was significantly higher in group 1 than in group 2 (5.3 ± 1.8 mSv vs. 2.7 ± 0.7 mSv, p < 0.001). Conclusion: The novel whole-heart coverage CT scanner allows to perform CCTA with a single-acquisition protocol with high image quality and low radiation exposure in AF patients.
Published: 2019

20. Diagnostic accuracy of coronary CT angiography performed in 100 consecutive patients with coronary stents using a whole-organ high-definition CT scanner

Author: Andreini, D, Pontone, G, Mushtaq, S, Conte, E, Guglielmo, M, Mancini, M, Annoni, A, Baggiano, A, Formenti, A, Montorsi, P, Magatelli, M, Di Odoardo, L, Melotti, E, Resta, M, Muscogiuri, G, Fiorentini, C, Bartorelli, A, Pepi, M, Andreini D, Pontone G, Mushtaq S, Conte E, Guglielmo M, Mancini ME, Annoni A, Baggiano A, Formenti A, Montorsi P, Magatelli M, Di Odoardo L, Melotti E, Resta M, Muscogiuri G, Fiorentini C, Bartorelli AL, Pepi M., Andreini, D, Pontone, G, Mushtaq, S, Conte, E, Guglielmo, M, Mancini, M, Annoni, A, Baggiano, A, Formenti, A, Montorsi, P, Magatelli, M, Di Odoardo, L, Melotti, E, Resta, M, Muscogiuri, G, Fiorentini, C, Bartorelli, A, Pepi, M, Andreini D, Pontone G, Mushtaq S, Conte E, Guglielmo M, Mancini ME, Annoni A, Baggiano A, Formenti A, Montorsi P, Magatelli M, Di Odoardo L, Melotti E, Resta M, Muscogiuri G, Fiorentini C, Bartorelli AL, and Pepi M.
Abstract: Aims: To evaluate image quality, interpretability, diagnostic accuracy and radiation exposure of coronary CT angiography (CCTA) performed with a new scanner equipped with 0.23-mm spatial resolution, new generation iterative reconstruction, 0.28-second gantry rotation time and intra-cycle motion-correction algorithm in consecutive patients with coronary stents, including those with high heart rate (HR) and atrial fibrillation (AF). Materials and methods: We enrolled 100 consecutive patients (85 males, mean age 65 ± 10 years) with previous coronary stent implantation scheduled for clinically indicated non-emergent invasive coronary angiography (ICA). Image quality, coronary interpretability and diagnostic accuracy vs. ICA were evaluated and the effective dose (ED) was recorded. Results: Mean HR during the scan was 67 ± 13 bpm. Twenty-six patients had >65 bpm HR during scanning and 13 patients had AF. Overall, image quality was high (Likert = 3.2 ± 0.9). Stent interpretability was 95.8% (184/192 stents). Among 192 stented segments, CCTA correctly identified 22 out of 24 with >50% in-stent restenosis (ISR) (sensitivity 92%). In a stent-based analysis, specificity, positive and negative predictive values and diagnostic accuracy for ISR detection were 91%, 99%, 60% and 91%, respectively. In a patient-based analysis, CCTA diagnostic accuracy was 85%. Overall, mean ED of CCTA was 2.4 ± 1.2 mSv. Conclusions: A whole-organ CT scanner was able to evaluate coronary stents with good diagnostic performance and low radiation exposure, also in presence of unfavorable HR and heart rhythm. Translational aspect: The present study is the first to evaluate the CCTA capability of detecting in-stent restenosis in consecutive patients, including those with high HR and AF, using a recent scanner generation that combines improved spatial and temporal resolution with wide coverage. Using the whole-organ high-definition CT scanner we obtained high quality images of coronary stents with g
Published: 2019

21. Dual antiplatelet therapy duration after coronary stenting in clinical practice: results of an EAPCI survey

Author: Valgimigli, M, Costa, F, Byrne, R, Haude, M, Baumbach, A, Windecker, S, Aaroe, J, Aasa, M, Abdel-Salam, Am, Alaarag, Af, Accardi, R, Adel, A, Alcazar De La Torre, E, Alejos, R, Alfonso Jimenez, V, Alhashimi, Hmm, Aljeboury, A, Almeida De Sousa, J, Almusawi, A, Alshaikha, M, Altaf, S, Altahmody, Kea, Alvarez Contreras, Lr, Amarasena, N, Amoroso, G, Anderson, R, Ando, G, Andrade, J, Andreou, Ay, Angulo, J, Antonio, T, Aprigliano, G, Aquilina, M, Arafa, Seo, Aramberry, L, Arampatzis, Ca, Araujo, Jj, Asher, E, Ates, I, Athanasias, D, Auer, J, Auffret, V, Ayala, Fj, Baba, C, Baglioni, P, Bagur, R, Balam-Ortiz, E, Balducelli, M, Bam Pas, G, Barbash, Im, Barbosa, Ahp, Barbosa, R, Barnay, P, Barroso, L, Basti, A, Bax, M, Bayet, G, Beijk, Ma, Beltran, R, Berenguer Jofresa, A, Berroth, R, Berti, S, Berumen Dominguez, Le, Bhasin, A, Bhaya, M, Bianco, M, Biasco, L, Bikicki, M, Bonarjee, Vvs, Bonechi, F, Borges Santos, M, Boshev, M, Bouferrouk, A, Bounartzidi, M, Bousoula, E, Brie, D, Brtko, M, Brugaletta, S, Brull, Dj, Buchter, B, Buendia, R, Burzotta, F, Butz, T, Buzzetti, F, Bychowiec, B, Cadeddu, M, Campanile, A, Carneiro, Jg, Carrilho-Ferreira, P, Carrillo Guevara, Je, Carter, Aj, Casal-Heredia, H, Castiglioni, B, Castro Fabiano, L, Cavalcante Silva, R, Cavalcanti De Oliveira, D, Cavalcanti, Rc, Cavazza, C, Centemero, Mp, Chabane, Hk, Chamie, D, Chatzis, D, Chaves, Aj, Cheng, S, Chinchilla, H, Ciabatti, N, Cirillo, P, Citaku, H, Claeys, Mj, Clifford, C, Coceani, M, Coggiola, J, Cohen, Dj, Conway, Dsg, Cornelis, K, Coroleu, Sf, Corral, Jm, Cortese, B, Coskun, U, Costa, Ra, Coste, P, Coufal, Z, Cox, S, Cozma, A, Crean, P, Crenshaw, Mh, Cristian, U, Cruz-Alvarado, Je, Cuculi, F, Cuenza, L, Cyrne Carvalho, H, D'Ascenzo, F, D'Urbano, M, Damonte, A, Dan Florin, F, Dana, A, Dangoisse, V, De Backer, O, De Cock, D, De Vita, M, Debski, A, Delgado, A, Devadathan, S, Dhamrait, S, Di Lorenzo, E, Di Serafino, D, Diego-Nieto, A, Dievart, F, Diez, Jl, Dimitriadis, K, Dina, C, Doerner, O, Donahue, M, Donis, J, Drieghe, B, Drissi, Mf, Du Fretay, H, Dziewierz, A, Echavarria-Pinto, M, Echeverria Romero, Rg, Economou, F, Eftychiou, C, Egdell, R, El Hosieny, A, El Meguid, K, Elabbassi, W, Elesgerli, S, Elghetany, H, Elizondo, Jc, Elkahlout, A, Elrowiny, R, Elserafy, As, Emam, A, Emara, A, Emmanouil, P, Ercilla, J, Erglis, A, Eslam Taha, E, Esmaeil, S, Esposito, G, Ettori, F, Eugenio, N, Everaert, B, Ezquerra Aguilar, W, Falu, R, Farag, E, Farjalla, J, Feldman, L, Feldman, M, Felice, H, Fernandez-Nofrerias, E, Fernandez-Rodriguez, D, Ferranti, F, Ferreira, Q, Ferrone, M, Fleischmann, C, Flessas, D, Formigli, D, Fozilov, H, Fraccaro, C, Freitas, Jo, Fresco, C, Fridrich, V, Furmaniuk, J, Gagnor, A, Galasso, G, Galeazzi, Gl, Galli, S, Galvez Villacorta, V, Gandolfo, C, Garcia, E, Garcia-Blas, S, Garducci, S, Garg, S, Garro, N, Gatto, L, Georgiou, Mg, Ghanem, I, Ghose, T, Giacchi, G, Giang, Pt, Giesler, T, Giovino, M, Girardi, P, Girasis, C, Giunio, L, Giustino, G, Glatthor, C, Glogar, Hd, Golledge, P, Gomez Moreno, J, Gomez Recio, M, Gommeaux, A, Grantalis, G, Greco, F, Grundeken, Mj, Grunert, S, Gudmundsdottir, I, Guenoun, M, Guerios, E, Gupta, R, Gupta, S, Gutierrez, C, Hafeez, I, Halvorsen, S, Hamed Hussein, Ga, Hammoudeh, A, Hansen, Pr, Harb, S, Hawas, Jm, Hayrapetyan, H, Heintzen, Mp, Hengstenberg, C, Herity, N, Hernandez, F, Heyse, A, Hicham, D, Hildick-Smith, D, Hill, J, Hillani, A, Hiltrop, N, Hiramori, A, Hobson, Ar, Homan, Dj, Hooda, A, Ielasi, A, Ierna, S, Iftikhar, Ak, Ilic, I, Imai, Y, Imperadore, F, Indolfi, C, Iorga, V, Ipek, E, Ito, S, Jacksch, R, Jae-Sik, J, James, S, Jamshidi, P, Jerbi, J, Jimenez Quevedo, P, Jimenez-Navarro, M, Jimenez-Santos, M, Jin, Qh, Joksas, V, Jovic, D, Junejo, S, Kallel, R, Kamal, A, Kamiya, H, Kannan, D, Kantaria, M, Kapetanopoulos, A, Kara Ali, B, Karjalainen, Pp, Karthikeyan, Vj, Kato, R, Katsikis, A, Kefer, J, Keta, D, Ketteler, T, Khan, M, Kharlamov, A, Kinani, A, Kinani, T, Kinnaird, T, Kislo, A, Kiviniemi, T, Kleiban, A, Kluck, B, Kocayigit, I, Kokis, A, Komiyama, N, Konstantinos, L, Kordalis, A, Kozak, M, Krecki, R, Kristensen, Sd, Krizanic, F, Krsticevic, L, Kuex, H, Kukreja, N, Kulic, M, Kulikovskikh, Yv, Kulkarni, P, Kumar, N, Kumar Soni, A, Kuzmenko, E, L'Allier, Pl, Langner, O, Lapin, O, Lauer, B, Leclercq, F, Leibundgut, G, Leon Aliz, E, Leon, C, Leon, K, Leoncini, M, Leone, Am, Leroux, L, Lesiak, M, Letilovic, T, Lev, E, Linares Vicente, Ja, Lindsay, S, Loh, Ph, Loncar, G, Loo, B, Lopez, Mb, Lopez-Cuellar, J, Lozano, I, Luigia, P, Lunde, K, Lyczywek, M, Macdougall, D, Mafrici, A, Magni, V, Magro, M, Mainar, V, Makarovic, Z, Malik, N, Maly, M, Mansour, S, Marenco, Re, Maresta, A, Marinho, Ge, Marino, Rl, Marinucci, L, Martins, Hc, Martins, J, Mashayekhi, K, Masood, A, Maurer, E, Mavrogianni, Ad, Mazurek, T, Medina, A, Mehilli, J, Mellwig, Kp, Mendez, M, Mendiz, Oa, Meneses, A, Mercado, La, Mereuta, A, Mezzapelle, G, Milanovic, N, Mohamed, Sm, Mohanad, A, Mohanty, A, Moorthy, N, Morales, Fj, More, R, Moreno Samos, Jc, Moreno-Martinez, Fl, Moscato, F, Mossmann, M, Mrevlje, B, Muller-Eichelberg, A, Musumeci, G, Nadir Khan, M, Najim, S, Nakamura, S, Nakao, F, Naveri, H, Negus, B, Nerla, R, Nguyen, Ht, Niess, Gs, Nikas, Dn, Niroomand, F, Niva, J, Nogueira, Jw, Nombela-Franco, L, Notrica, M, Nouri, B, Nugue, O, Nunes, Gl, Ober, M, Ochoa, J, J. H., O, Ojeda, S, Oktay Tureli, H, Olowe, Y, Oluseun, A, Opolski, G, Ornelas, Ce, Otasevic, P, Ozturk, A, Padilla, F, Pagny, Jy, Paolantonio, D, Papaioannou, Gi, Parodi, G, Patil, Sn, Pavei, A, Pavia, A, Pavlidis, A, Pell, A, Percoco, Gf, Pernasetti, Lv, Pescoller, F, Petropoulakis, P, Piatti, L, Picardi, E, Pieroni, Dm, Pina, J, Pinheiro, Lf, Pinto, Fj, Pipa, Jl, Piroth, Z, Pisano, F, Podbregar, M, Polak, G, Polimeni, A, Postadzhiyan, A, Postu, M, Poulimenos, Le, Pow Chon Long, F, Poyet, R, Pradhan, A, Predescu, Lm, Prida, Xe, Saad, A, Prog, R, Pulikal, Dga, Qiangzhong, Pi, Radu, Md, Rajendran, D, Ram Anil Raj, Mr, Ramazzotti, V, Rapacciuolo, A, Ratib, K, Raungaard, B, Raviola, E, Reppas, E, Reyes, Ja, Rezek, M, Riess, Gj, Rifaie, O, Rigattieri, S, Rissanen, T, Ristic, Ad, Rittger, H, Roberts, J, Rodriguez Saavedra, A, Roik, M, Roshan Rao, K, Routledge, H, Rubboli, A, Rudolph, T, Rudzitis, A, Ruiters, A, Ruiz Ros, Ja, Ruiz-Garcia, J, Ruiz-Nodar, Jm, Sabate, M, Sabnis, G, Sabouret, P, Sacra, C, Saghatelyan, M, Sahin, M, Said, S, Salachas, Aj, Salas Llamas, Jp, Salih, A, Sanchez, Od, Sanchez-Gila, J, Sanchez-Perez, I, Santarelli, A, Sardovski, Sarenac, D, Sarma, J, Sarno, G, Savonitto, S, Sayied Abdullah, A, Schafer, A, Scherillo, M, Schneider, H, Schuhlen, H, Sciahbasi, A, Seca, L, Sedlon, P, Semenka, J, Serra, La, Sesana, M, Sethi, A, Sgueglia, Ga, Shaheen, S, Shahri, H, Sheiban, I, Shyu, Kg, Silva, Cef, Sionis, D, Siqueira, Da, Siqueira, Mj, Smits, P, Sobhy, M, Sokolov, M, Soliman, S, Somani, An, Sridhar, G, Stakos, D, Stasek, J, Stefanini, G, Steigen, Tk, Stewart, Stipal, R, Stochino, Ml, Stoel, Mg, Subla, Rm, Suliman, A, Summaria, F, Stoyanov, N, Syed, Aa, Tanaka, Y, Tashani, A, Tauzin, S, Tawade, N, Tawfik, M, Tayeh, O, Terzic, I, Testa, L, Thevan, B, Thiam, M, Tiecco, F, Tierala, I, Tilea, I, Tilsted, Hh, Tomasik, Ar, Tonev, I, Torres Bosco, A, Tousek, P, Townend, J, Tran Ngoc, T, Triantafyllou, K, Tsigkas, G, Tsioufis, C, Turri, M, Tyligadis, G, Ugo, F, 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C., Mantyla, P., Mariano, E., Marsit, N., Mcdonough, T. J., Medda, M., Mejia Viana, S., Merigo Azpir, C. A., Mitreski, S., Moreno, R., Moreu, J., Muehler, M., Muir, D., Munoz Molina, R., Musilli, N., Myc, J., Nadra, I., Nagy, C. D., Narayanan, A., Neugebauer, P., Nguyen, M., Nick, H., Nicolino, A., Obradovic, S. D., Paizis, I., Panagiotis, P., Park, S. D., Park, S. J., Pasquetto, G., Patel, D., Paunovic, D., Pedon, L., Pereira Machado, F., Pershukov, H., Petrou, E., Pinton, F. A., Preti, G., Puri, R., Pyxaras, S. A., Quintanilla, J., Rhouati, A., Ribeiro De Oliveira, I., Rivetti, L., Rodriguez, A. E., Rotevatn, S., Rubartelli, P., Sachdeva, R., Sanchez-Perez, H., Sangiorgi, G., Santoro, G. M., Saporito, F., Scappaticci, M., Schmermund, A., Schmidt, J. E., Schmitz, T., Schneider, T. I., Schuchlenz, H., Sepulveda Varela, P., Shaw, E., Silva Marques, J., Skalidis, E., Slhessarenko, J., Spaulding, C., Stankovic, G., Suwannasom, P., Synetos, A., Szuster, E., Taha, S., Tavano, D., Tebet, M., Thury, A., Toutouzas, K., Triantafyllis, A. S., Tsikaderis, D., Tumscitz, C., Tzanogiorgis, I., Udovichenko, A., Ulrike, N., Unikas, R., Valerio, M. G., Van Mieghem, C., Vandendriessche, T., Vavlukis, M., Vigna, C., Vilar, J. V., Vizzari, G., Voudris, V., Wafa, S., Wagner, D. R., Wichter, T., Wiedemann, S., Williams, P. D., Woody, W., Yding, A., Zachow, G., and Webster, M.
Subjects: Male, medicine.medical_specialty, Time Factors, Percutaneous, Time Factor, Psychological intervention, Alternative medicine, MEDLINE, Practice Patterns, Drug Administration Schedule, acute coronary syndrome, Settore MED/11, Percutaneous Coronary Intervention, Pharmacotherapy, Drug Therapy, Physicians, Surveys and Questionnaires, drug-eluting stent, Humans, Surveys and Questionnaire, Medicine, Practice Patterns, Physicians', health care economics and organizations, clopidogrel, dual antiplatelet therapy (DAPT), stable coronary artery disease, Drug Therapy, Combination, Evidence-Based Medicine, Health Care Surveys, Platelet Aggregation Inhibitors, Practice Guidelines as Topic, Practice Patterns, Physicians, Treatment Outcome, Stents, business.industry, Platelet Aggregation Inhibitor, Coronary stenting, Evidence-based medicine, Middle Aged, Surgery, Clinical trial, Health Care Survey, Combination, Emergency medicine, Female, Cardiology and Cardiovascular Medicine, business, Human
Abstract: AIMS Our aim was to report on a survey initiated by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) concerning opinion on the evidence relating to dual antiplatelet therapy (DAPT) duration after coronary stenting. METHODS AND RESULTS Results from three randomised clinical trials were scheduled to be presented at the American Heart Association Scientific Sessions 2014 (AHA 2014). A web-based survey was distributed to all individuals registered in the EuroIntervention mailing list (n=15,200) both before and after AHA 2014. A total of 1,134 physicians responded to the first (i.e., before AHA 2014) and 542 to the second (i.e., after AHA 2014) survey. The majority of respondents interpreted trial results consistent with a substantial equipoise regarding the benefits and risks of an extended versus a standard DAPT strategy. Two respondents out of ten believed extended DAPT should be implemented in selected patients. After AHA 2014, 46.1% of participants expressed uncertainty about the available evidence on DAPT duration, and 40.0% the need for clinical guidance. CONCLUSIONS This EAPCI survey highlights considerable uncertainty within the medical community with regard to the optimal duration of DAPT after coronary stenting in the light of recent reported trial results. Updated recommendations for practising physicians to guide treatment decisions in routine clinical practice should be provided by international societies.
Published: 2015
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22. Quantitative vs. qualitative evaluation of static stress computed tomography perfusion to detect haemodynamically significant coronary artery disease

Author: Pontone, G, Andreini, D, Guaricci, A, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Soldi, M, Fazzari, F, Berzovini, C, Pasquini, A, Ciancarella, P, Mushtaq, S, Conte, E, Calligaris, G, De Martini, S, Ferrari, C, Galli, S, Grancini, L, Ravagnani, P, Teruzzi, G, Trabattoni, D, Fabbiocchi, F, Lualdi, A, Montorsi, P, Rabbat, M, Bartorelli, A, Pepi, M, Pontone G, Andreini D, Guaricci AI, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Soldi M, Fazzari F, Berzovini C, Pasquini A, Ciancarella P, Mushtaq S, Conte E, Calligaris G, De Martini S, Ferrari C, Galli S, Grancini L, Ravagnani P, Teruzzi G, Trabattoni D, Fabbiocchi F, Lualdi A, Montorsi P, Rabbat MG, Bartorelli AL, Pepi M., Pontone, G, Andreini, D, Guaricci, A, Guglielmo, M, Baggiano, A, Muscogiuri, G, Fusini, L, Soldi, M, Fazzari, F, Berzovini, C, Pasquini, A, Ciancarella, P, Mushtaq, S, Conte, E, Calligaris, G, De Martini, S, Ferrari, C, Galli, S, Grancini, L, Ravagnani, P, Teruzzi, G, Trabattoni, D, Fabbiocchi, F, Lualdi, A, Montorsi, P, Rabbat, M, Bartorelli, A, Pepi, M, Pontone G, Andreini D, Guaricci AI, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Soldi M, Fazzari F, Berzovini C, Pasquini A, Ciancarella P, Mushtaq S, Conte E, Calligaris G, De Martini S, Ferrari C, Galli S, Grancini L, Ravagnani P, Teruzzi G, Trabattoni D, Fabbiocchi F, Lualdi A, Montorsi P, Rabbat MG, Bartorelli AL, and Pepi M.
Abstract: Aims To compare the diagnostic accuracy of stress computed tomography myocardial perfusion (CTP) for the detection of significant coronary artery disease with visual approach vs. quantitative analysis with transmural perfusion ratio (TPR) in consecutive symptomatic patients scheduled for invasive coronary angiography (ICA) plus invasive fractional flow reserve (FFR). Methods and results Eighty-eight consecutive symptomatic patients underwent rest coronary computed tomography angiography (cCTA) followed by static stress-CTP. Diagnostic accuracy of cCTA + stress-CTP with visual evaluation and with TPR measurement was calculated and compared with ICA and invasive FFR. Addition of stress-CTP with qualitative evaluation to rest-cCTA showed sensitivity, specificity, negative and positive predictive values, and accuracy at a vessel and patient level of 92%, 92%, 97%, 82%, 92% and 98%, 80%, 97%, 82%, 89%, respectively indicating a significant improvement of specificity, positive predictive value, and accuracy values vs. rest-cCTA in both models. Similarly, addition of stress-CTP with TPR evaluation to rest-cCTA showed sensitivity, specificity, negative and positive predictive values, and accuracy at a vessel and patient level of 84%, 90%, 93%, 76%, 88% and 91%, 71%, 89%, 75%, 81%, respectively indicating a significant improvement of specificity, positive predictive value values vs. rest-cCTA only in a vessel-based model and of positive predictive value in a patient-based model. When cCTA + stress-CTP with qualitative evaluation was compared with cCTA + stress-CTP with TPR estimation, no differences were found in terms of diagnostic performance. Conclusion The addition of stress-CTP with visual evaluation to cCTA imaging has similar diagnostic performance when compared with the quantitative analysis of myocardial perfusion based on TPR measurement.
Published: 2018

23. Rationale and design of advantage (additional diagnostic value of CT perfusion over coronary CT angiography in stented patients with suspected in-stent restenosis or coronary artery disease progression) prospective study

Author: Andreini, D, Mushtaq, S, Pontone, G, Conte, E, Sonck, J, Collet, C, Guglielmo, M, Baggiano, A, Trabattoni, D, Galli, S, Montorsi, P, Ferrari, C, Fabbiocchi, F, De Martini, S, Annoni, A, Mancini, M, Formenti, A, Magatelli, M, Resta, M, Consiglio, E, Muscogiuri, G, Fiorentini, C, Bartorelli, A, Pepi, M, Andreini D, Mushtaq S, Pontone G, Conte E, Sonck J, Collet C, Guglielmo M, Baggiano A, Trabattoni D, Galli S, Montorsi P, Ferrari C, Fabbiocchi F, De Martini S, Annoni A, Mancini ME, Formenti A, Magatelli M, Resta M, Consiglio E, Muscogiuri G, Fiorentini C, Bartorelli AL, Pepi M., Andreini, D, Mushtaq, S, Pontone, G, Conte, E, Sonck, J, Collet, C, Guglielmo, M, Baggiano, A, Trabattoni, D, Galli, S, Montorsi, P, Ferrari, C, Fabbiocchi, F, De Martini, S, Annoni, A, Mancini, M, Formenti, A, Magatelli, M, Resta, M, Consiglio, E, Muscogiuri, G, Fiorentini, C, Bartorelli, A, Pepi, M, Andreini D, Mushtaq S, Pontone G, Conte E, Sonck J, Collet C, Guglielmo M, Baggiano A, Trabattoni D, Galli S, Montorsi P, Ferrari C, Fabbiocchi F, De Martini S, Annoni A, Mancini ME, Formenti A, Magatelli M, Resta M, Consiglio E, Muscogiuri G, Fiorentini C, Bartorelli AL, and Pepi M.
Abstract: Background: Recent studies demonstrated a significant improvement in the diagnostic performance of coronary CT angiography (CCTA) for the evaluation of in-stent restenosis (ISR). However, coronary stent assessment is still challenging, especially because of beam-hardening artifacts due to metallic stent struts and high atherosclerotic burden of non-stented segments. Adenosine-stress myocardial perfusion assessed by CT (CTP) recently demonstrated to be a feasible and accurate tool for evaluating the functional significance of coronary stenoses in patients with suspected coronary artery disease (CAD). Yet, scarce data are available on the performance of CTP in patients with previous stent implantation. Aim of the study: We aim to assess the diagnostic performance of CCTA alone, CTP alone and CCTA plus CTP performed with a new scanner generation using quantitative invasive coronary angiography (ICA) and invasive fractional flow reserve (FFR) as standard of reference. Methods: We will enroll 300 consecutive patients with previous stent implantation, referred for non-emergent and clinically indicated invasive coronary angiography (ICA) due to suspected ISR or progression of CAD in native coronary segments. All patients will be subjected to stress myocardial CTP and a rest CCTA. The first 150 subjects will undergo static CTP scan, while the following 150 patients will undergo dynamic CTP scan. Measurement of invasive FFR will be performed during ICA when clinically indicated. Results: The primary study end points will be: 1) assessment of the diagnostic performance (diagnostic rate, sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy) of CCTA, CTP, combined CCTA-CTP and concordant CCTA-CTP vs. ICA as standard of reference in a territory-based and patient-based analysis; 2) assessment of sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of CCTA, CTP, combined CCTA-CTP an
Published: 2018

24. Two-year clinical outcomes of patients treated with overlapping absorb scaffolds: An analysis of the ABSORB EXTEND single-arm study

Author: Ribamar Costa, J, Abizaid, A, Bartorelli, AL, Whitbourn, R, Serruys, PW, Smits, PC, Ribamar Costa, J, Abizaid, A, Bartorelli, AL, Whitbourn, R, Serruys, PW, and Smits, PC
Abstract: BACKGROUND: Preclinical data showed that overlapping (OVP) scaffolds might result in delayed healing and strut coverage compared to nonOVP scaffold segments. Furthermore, OVP in patients could result in increased periprocedure myocardial infarction (MI) rate secondary to side branch occlusion; however, little is known whether this may have an impact on long-term clinical outcomes. METHODS: ABSORB EXTEND is a prospective, single-arm, open-label clinical study in which 812 patients were enrolled at 56 sites. In this study, we compared the immediate and 2-year clinical outcomes of patients with OVP scaffolds (n = 115) to those of patients with nonOVP scaffolds (n = 697). The primary objective was the comparison of major adverse cardiac event (MACE) (cardiac death, MI and ischemic-driven target lesion revascularization [TLR]) and scaffold thrombosis (ST) rates up to 2 years. RESULTS: Baseline clinical and angiographic characteristics were comparable between cohorts except for longer lesions in the OVP patients as expected (16.7 ± 7.3 vs. 11.6 ± 4.4 mm, P < 0.0001), higher lesion complexity (B2) and numerically smaller vessel size. In-hospital, there was a marked increase in MACE in the OVP cohort (7.0 vs. 0.9%, P = 0.002), exclusively driven by a higher rate of periprocedure MI (7.0 vs. 0.9%, P = 0.002). Long-term MACE did not significantly differ between groups (10.4% in the OVP cohort vs. 6.6% in the no-OVP group, P = 0.1) with comparable rates of cardiac death (0.9 vs. 1.2%, P = 1.0) and ischemia-driven TLR (1.7 vs. 2.5%, P = 1.0). Cumulative incidence of MI was higher in the OVP cohort (7.8 vs. 3.0%, P = 0.02). Of note, the rate of MI between hospital discharge and 2-year follow-up was lower in the OVP cohort (0.8 vs. 2.1%, P = 0.04). Cumulative incidence of definite/probable ST was relatively low and comparable between groups (1.8 vs. 1.5%, P = 0.7). CONCLUSIONS: In this low-to-moderate complex population treated with the ABSORB scaffold the OVP group showed a high
Published: 2018

25. Impact of a New Adaptive Statistical Iterative Reconstruction (ASIR)-V Algorithm on Image Quality in Coronary Computed Tomography Angiography

Author: Pontone, G, Muscogiuri, G, Andreini, D, Guaricci, A, Guglielmo, M, Baggiano, A, Fazzari, F, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, E, Verdecchia, M, Campari, A, Martini, C, Gatti, M, Fusini, L, Bonfanti, L, Consiglio, E, Rabbat, M, Bartorelli, A, Pepi, M, Pontone G, Muscogiuri G, Andreini D, Guaricci AI, Guglielmo M, Baggiano A, Fazzari F, Mushtaq S, Conte E, Annoni A, Formenti A, Mancini E, Verdecchia M, Campari A, Martini C, Gatti M, Fusini L, Bonfanti L, Consiglio E, Rabbat MG, Bartorelli AL, Pepi M., Pontone, G, Muscogiuri, G, Andreini, D, Guaricci, A, Guglielmo, M, Baggiano, A, Fazzari, F, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, E, Verdecchia, M, Campari, A, Martini, C, Gatti, M, Fusini, L, Bonfanti, L, Consiglio, E, Rabbat, M, Bartorelli, A, Pepi, M, Pontone G, Muscogiuri G, Andreini D, Guaricci AI, Guglielmo M, Baggiano A, Fazzari F, Mushtaq S, Conte E, Annoni A, Formenti A, Mancini E, Verdecchia M, Campari A, Martini C, Gatti M, Fusini L, Bonfanti L, Consiglio E, Rabbat MG, Bartorelli AL, and Pepi M.
Abstract: Rationale and objectives: A new postprocessing algorithm named adaptive statistical iterative reconstruction (ASIR)-V has been recently introduced. The aim of this article was to analyze the impact of ASIR-V algorithm on signal, noise, and image quality of coronary computed tomography angiography. Materials and Methods: Fifty consecutive patients underwent clinically indicated coronary computed tomography angiography (Revolution CT; GE Healthcare, Milwaukee, WI). Images were reconstructed using filtered back projection and ASIR-V 0%, and a combination of filtered back projection and ASIR-V 20%–80% and ASIR-V 100%. Image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were calculated for left main coronary artery (LM), left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA) and were compared between the different postprocessing algorithms used. Similarly a four-point Likert image quality score of coronary segments was graded for each dataset and compared. A cutoff value of P <.05 was considered statistically significant. Results: Compared to ASIR-V 0%, ASIR-V 100% demonstrated a significant reduction of image noise in all coronaries (P <.01). Compared to ASIR-V 0%, SNR was significantly higher with ASIR-V 60% in LM (P <.01), LAD (P <.05), LCX (P <.05), and RCA (P <.01). Compared to ASIR-V 0%, CNR for ASIR-V ≥60% was significantly improved in LM (P <.01), LAD (P <.05), and RCA (P <.01), whereas LCX demonstrated a significant improvement with ASIR-V ≥80%. ASIR-V 60% had significantly better Likert image quality scores compared to ASIR-V 0% in segment-, vessel-, and patient-based analyses (P <.01). Conclusions: Reconstruction with ASIR-V 60% provides the optimal balance between image noise, SNR, CNR, and image quality.
Published: 2018

26. Diagnostic accuracy of simultaneous evaluation of coronary arteries and myocardial perfusion with single stress cardiac computed tomography acquisition compared to invasive coronary angiography plus invasive fractional flow reserve

Author: Pontone, G, Baggiano, A, Andreini, D, Guaricci, A, Guglielmo, M, Muscogiuri, G, Fusini, L, Soldi, M, Del Torto, A, Mushtaq, S, Conte, E, Calligaris, G, De Martini, S, Ferrari, C, Galli, S, Grancini, L, Olivares, P, Ravagnani, P, Teruzzi, G, Trabattoni, D, Fabbiocchi, F, Montorsi, P, Rabbat, M, Bartorelli, A, Pepi, M, Pontone G, Baggiano A, Andreini D, Guaricci AI, Guglielmo M, Muscogiuri G, Fusini L, Soldi M, Del Torto A, Mushtaq S, Conte E, Calligaris G, De Martini S, Ferrari C, Galli S, Grancini L, Olivares P, Ravagnani P, Teruzzi G, Trabattoni D, Fabbiocchi F, Montorsi P, Rabbat MG, Bartorelli AL, Pepi M., Pontone, G, Baggiano, A, Andreini, D, Guaricci, A, Guglielmo, M, Muscogiuri, G, Fusini, L, Soldi, M, Del Torto, A, Mushtaq, S, Conte, E, Calligaris, G, De Martini, S, Ferrari, C, Galli, S, Grancini, L, Olivares, P, Ravagnani, P, Teruzzi, G, Trabattoni, D, Fabbiocchi, F, Montorsi, P, Rabbat, M, Bartorelli, A, Pepi, M, Pontone G, Baggiano A, Andreini D, Guaricci AI, Guglielmo M, Muscogiuri G, Fusini L, Soldi M, Del Torto A, Mushtaq S, Conte E, Calligaris G, De Martini S, Ferrari C, Galli S, Grancini L, Olivares P, Ravagnani P, Teruzzi G, Trabattoni D, Fabbiocchi F, Montorsi P, Rabbat MG, Bartorelli AL, and Pepi M.
Abstract: Background: Coronary computed tomography angiography (cCTA) has limited diagnostic accuracy in patients with intermediate to high pre-test likelihood of coronary artery disease (CAD) that may have large amounts of coronary calcium. Stress computed tomography myocardial perfusion (CTP) has emerged as a valuable strategy, combining anatomical and functional assessment of CAD. Purpose of the study is to evaluate the diagnostic accuracy of combining coronary artery imaging and myocardial perfusion in a single stress dataset versus invasive coronary angiography (ICA) and invasive fractional flow reserve (FFR) as reference standard. Methods: One-hundred-thirty consecutive symptomatic patients (age: 65 ± 9 years; men: 70%) scheduled for clinically indicated ICA plus invasive FFR were prospectively enrolled. cCTA + CTP were simultaneously evaluated in a single stress-dataset by blinded readers and compared to ICA and invasive FFR findings. Results: CTP was successfully performed in all patients. The most common artifacts observed in the stress dataset for coronary artery imaging were blooming effect and motion effect related. Overall evaluability of coronary arteries by using cCTA stress dataset was 93%. In a vessel and patient-based model, stress cCTA + stress CTP showed sensitivity, specificity, negative predictive value, positive predictive value and diagnostic accuracy of 93%, 94%, 97%, 85%, 94%, and 98%, 86%, 98%, 85%, 92%, respectively. The overall effective dose (ED) of stress protocol acquisition alone was 2.5 ± 1.1 mSv. Conclusions: Simultaneous evaluation of coronary arteries and myocardial perfusion with single stress acquisition is feasible and it has diagnostic accuracy and low ED to identify functionally significant stenosis in patients with intermediate to high risk for CAD.
Published: 2018

27. Prognostic Stratification of Patients With ST-Segment-Elevation Myocardial Infarction (PROSPECT): A Cardiac Magnetic Resonance Study

Author: Pontone, G, Guaricci, A, Andreini, D, Ferro, G, Guglielmo, M, Baggiano, A, Fusini, L, Muscogiuri, G, Lorenzoni, V, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, M, Carità, P, Verdecchia, M, Pica, S, Fazzari, F, Cosentino, N, Marenzi, G, Rabbat, M, Agostoni, P, Bartorelli, A, Pepi, M, Masci, P, Pontone G, Guaricci AI, Andreini D, Ferro G, Guglielmo M, Baggiano A, Fusini L, Muscogiuri G, Lorenzoni V, Mushtaq S, Conte E, Annoni A, Formenti A, Mancini ME, Carità P, Verdecchia M, Pica S, Fazzari F, Cosentino N, Marenzi G, Rabbat MG, Agostoni P, Bartorelli AL, Pepi M, Masci PG., Pontone, G, Guaricci, A, Andreini, D, Ferro, G, Guglielmo, M, Baggiano, A, Fusini, L, Muscogiuri, G, Lorenzoni, V, Mushtaq, S, Conte, E, Annoni, A, Formenti, A, Mancini, M, Carità, P, Verdecchia, M, Pica, S, Fazzari, F, Cosentino, N, Marenzi, G, Rabbat, M, Agostoni, P, Bartorelli, A, Pepi, M, Masci, P, Pontone G, Guaricci AI, Andreini D, Ferro G, Guglielmo M, Baggiano A, Fusini L, Muscogiuri G, Lorenzoni V, Mushtaq S, Conte E, Annoni A, Formenti A, Mancini ME, Carità P, Verdecchia M, Pica S, Fazzari F, Cosentino N, Marenzi G, Rabbat MG, Agostoni P, Bartorelli AL, Pepi M, and Masci PG.
Abstract: Background-Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment-elevation myocardial infarction. We evaluated the additional prognostic benefit of a CMR score over standard prognostic stratification with global registry of acute coronary events (GRACE) score and transthoracic echocardiography LVEF measurement. Methods and Results-Two hundred nine consecutive patients with ST-segment-elevation myocardial infarction (age, 61.4±11.4 years; 162 men) underwent transthoracic echocardiography and CMR after succesful primary percutaneous coronary intervention. Major adverse cardiac events (MACE) were assessed at a mean follow-up of 2.5±1.2 years. MACE occurred in 24 (12%) patients who at baseline showed higher GRACE risk score (P<0.01), lower LVEF with both transthoracic echocardiography and CMR, lower myocardial salvage index, and higher per-patient myocardial hemorrhage and microvascular obstruction prevalence and amount as compared with patients without MACE (P<0.01). The best cut-off values of transthoracic echocardiography-LVEF, CMR-LVEF, myocardial salvage index, and microvascular obstruction to predict MACE were 46.7%, 37.5%, 0.4, and 2.6% of left ventricular mass, respectively. Accordingly, a weighted CMR score, including the following 4 variables (CMR-LVEF, myocardial salvage index, microvascular obstruction, and myocardial hemorrhage), with a maximum of 17 points was calculated and included in the multivariable analysis showing that only CMR score (hazard ratio, 1.867 per SD increase [1.311-2.658]; P<0.001) was independently associated with MACE with the highest net reclassification improvement as compared to GRACE score and transthoracic echocardiography-LVEF measurement. Conclusions-CMR score provides incremental prognostic stratification as compared with GRACE score and transthoracic echocardiogr
Published: 2017

28. Additional value of inflammatory biomarkers and carotid artery disease in prediction of significant coronary artery disease as assessed by coronary computed tomography angiography

Author: Guaricci, A, Pontone, G, Fusini, L, De Luca, M, Cafarelli, F, Guglielmo, M, Baggiano, A, Beltrama, V, Muscogiuri, G, Mushtaq, S, Conte, E, Guglielmi, G, Andreini, D, Brunetti, N, Di Biase, M, Bartorelli, A, Pepi, M, Guaricci AI, Pontone G, Fusini L, De Luca M, Cafarelli FP, Guglielmo M, Baggiano A, Beltrama V, Muscogiuri G, Mushtaq S, Conte E, Guglielmi G, Andreini D, Brunetti ND, Di Biase M, Bartorelli AL, Pepi M., Guaricci, A, Pontone, G, Fusini, L, De Luca, M, Cafarelli, F, Guglielmo, M, Baggiano, A, Beltrama, V, Muscogiuri, G, Mushtaq, S, Conte, E, Guglielmi, G, Andreini, D, Brunetti, N, Di Biase, M, Bartorelli, A, Pepi, M, Guaricci AI, Pontone G, Fusini L, De Luca M, Cafarelli FP, Guglielmo M, Baggiano A, Beltrama V, Muscogiuri G, Mushtaq S, Conte E, Guglielmi G, Andreini D, Brunetti ND, Di Biase M, Bartorelli AL, and Pepi M.
Abstract: Aims To evaluate the relationship between an incremental model including cardiovascular risk factors, carotid disease, and inflammatory biomarkers to predict the presence of obstructive coronary artery disease (CAD). Methods and results A total of 134 consecutive and asymptomatic intermediate-risk patients (mean age 61+9 years, 52% men) were enrolled. Each subject underwent circulating levels assessment of interleukin (IL)-2r, IL-6, IL-8, IL-10, high-sensitivity Creactive protein (hs-CRP) and carotid and coronary artery evaluation using carotid ultrasound and coronary computed tomography angiography (CCTA), respectively. Carotid disease was diagnosed in 71 (53%) patients. Obstructive and multi-vessel CAD were found in 50 (37%) and 18 (14%) patients, respectively. Patients in whom CCTA showed multi-vessel CAD had a higher rate of carotid disease (89 vs. 46%, P ? 0.001) and increased values of all interleukins when compared with patients without multi-vessel obstructive CAD. The univariate and multivariate analysis showed that male gender, diabetes, carotid disease, and IL-6 were independently associated with obstructive CAD. At receiver operating characteristic curve analysis, the multivariate model (including male gender, carotid disease, IL-6. 5.9 pg/mL, and diabetes) showed the highest area under the curve for prediction of obstructive CAD, multi-vessel CAD, and high-risk plaque defined as mixed and/or remodelled plaque when compared with all other models (P, 0.001). Conclusion Among asymptomatic intermediate-risk patients, the presence of increased IL6 levels in addition to traditional risk factors (male gender with diabetes) and carotid artery disease predicts higher rates of obstructive CAD and it could be of help to identify which subset of asymptomatic patients could be referred to CCTA for screening.
Published: 2017

29. Stent thrombosis and bleeding complications after implantation of sirolimus-eluting coronary stents in an unselected worldwide population: a report from the e-SELECT (Multi-Center Post-Market Surveillance) registry

Author: Urban, P, Abizaid, A, Banning, A, Bartorelli, AL, Baux, AC, Džavík, V, Ellis, S, Gao, R, Holmes, D, Jeong, MH, Legrand, V, Neumann, FJ, Nyakern, M, Spaulding, C, and Worthley, S
Subjects: coronary stent, stent thrombosis, drug-eluting stent, sirolimus-eluting stent, antithrombotic therapy, bleeding complication
Abstract: OBJECTIVES: The aim of this study was to ascertain the 1-year incidence of stent thrombosis (ST) and major bleeding (MB) in a large, unselected population treated with sirolimus-eluting stents (SES). BACKGROUND: Stent thrombosis and MB are major potential complications of drug-eluting stent implantation. Their relative incidence and predisposing factors among large populations treated worldwide are unclear. METHODS: The SES were implanted in 15,147 patients who were entered in a multinational registry. We analyzed the incidence of: 1) definite and probable ST as defined by the Academic Research Consortium; and 2) MB, with the STEEPLE (Safety and efficacy of Enoxaparin in PCI) definition, together with their relation to dual antiplatelet therapy (DAPT) and to 1-year clinical outcomes. RESULTS: The mean age of the sample was 62 ± 11 years, 30.4% were diabetic, 10% had a Charlson comorbidity index ≥3, and 44% presented with acute coronary syndrome or myocardial infarction. At 1 year, the reported compliance with DAPT as recommended by the European Society of Cardiology guidelines was 86.3%. Adverse event rates were: ST 1.0%, MB 1.0%, mortality 1.7%, myocardial infarction 1.9%, and target lesion revascularization 2.3%. Multivariate analysis identified 9 correlates of ST and 4 correlates of MB. Advanced age and a high Charlson index were associated with an increased risk of both ST and MB. After ST, the 7-day and 1-year all-cause mortality was 30% and 35%, respectively, versus 1.5% and 10% after MB. Only 2 of 13,749 patients (0.015%) experienced both MB and ST during the entire 1-year follow-up period. CONCLUSIONS: In this worldwide population treated with ≥1 SES, the reported compliance with DAPT was good, and the incidence of ST and MB was low. Stent thrombosis and MB very rarely occurred in the same patient. (The e-SELECT Registry: a Multicenter Post-Market Surveillance; NCT00438919).
Published: 2016

30. The sirolimus-eluting Cypher Select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis: insights from the e-SELECT (Multicenter Post-Market Surveillance) registry

Author: Abizaid, A, Costa, JR, Banning, A, Bartorelli, AL, Dzavik, V, Ellis, S, Gao, R, Holmes, DR, Jeong, MH, Legrand, V, Neumann, FJ, Nyakern, M, Orlick, A, Spaulding, C, Worthley, S, and Urban, PM
Subjects: sirolimus-eluting stent(s), target lesion revascularization, in-stent restenosis
Abstract: OBJECTIVES: This study sought to compare the 1-year safety and efficacy of Cypher Select or Cypher Select Plus (Cordis Corporation, Bridgewater, New Jersey) sirolimus-eluting stents (SES) with the treatment of bare-metal stents (BMS) and drug-eluting stent (DES) in-stent restenosis (ISR) in nonselected, real-world patients. BACKGROUND: There is paucity of consistent data on DES for the treatment of ISR, especially, DES ISR. METHODS: The e-SELECT (Multicenter Post-Market Surveillance) registry is a Web-based, multicenter and international registry encompassing virtually all subsets of patients and lesions treated with at least 1 SES during the period from 2006 to 2008. We enrolled in this pre-specified subanalysis all patients with at least 1 clinically relevant BMS or DES ISR treated with SES. Primary endpoint was major adverse cardiac events and stent thrombosis rate at 1 year. RESULTS: Of 15,147 patients enrolled, 1,590 (10.5%) presented at least 1 ISR (BMS group, n = 1,235, DES group, n = 355). Patients with DES ISR had higher incidence of diabetes (39.4% vs. 26.9%, p < 0.001), renal insufficiency (5.8% vs. 2.3%, p = 0.003), and prior coronary artery bypass graft (20.5% vs. 11.8%, p < 0.001). At 1 year, death (1.4% for BMS vs. 2.1% for DES, p = 0.3) and myocardial infarction (2.4% for BMS and 3.3% for DES, p = 0.3) rates were similar, whereas ischemia-driven target lesion revascularization and definite/probable late stent thrombosis were higher in patients with DES ISR (6.9% vs. 3.1%, p = 0.003, and 1.8% vs. 0.5%, p = 0.04, respectively). CONCLUSIONS: Use of SES for either BMS or DES ISR treatment is safe and associated with low target lesion revascularization recurrence and no apparent safety concern.
Published: 2016
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31. The STRATEGY Study (Stress Cardiac Magnetic Resonance Versus Computed Tomography Coronary Angiography for the Management of Symptomatic Revascularized Patients) Resources and Outcomes Impact

Author: Pontone, G, Andreini, D, Guaricci, A, Rota, C, Guglielmo, M, Mushtaq, S, Baggiano, A, Beltrama, V, Fusini, L, Solbiati, A, Segurini, C, Conte, E, Gripari, P, Annoni, A, Formenti, A, Petulla', M, Lombardi, F, Muscogiuri, G, Bartorelli, A, Pepi, M, Pontone G, Andreini D, Guaricci AI, Rota C, Guglielmo M, Mushtaq S, Baggiano A, Beltrama V, Fusini L, Solbiati A, Segurini C, Conte E, Gripari P, Annoni A, Formenti A, Petulla' M, Lombardi F, Muscogiuri G, Bartorelli AL, Pepi M., Pontone, G, Andreini, D, Guaricci, A, Rota, C, Guglielmo, M, Mushtaq, S, Baggiano, A, Beltrama, V, Fusini, L, Solbiati, A, Segurini, C, Conte, E, Gripari, P, Annoni, A, Formenti, A, Petulla', M, Lombardi, F, Muscogiuri, G, Bartorelli, A, Pepi, M, Pontone G, Andreini D, Guaricci AI, Rota C, Guglielmo M, Mushtaq S, Baggiano A, Beltrama V, Fusini L, Solbiati A, Segurini C, Conte E, Gripari P, Annoni A, Formenti A, Petulla' M, Lombardi F, Muscogiuri G, Bartorelli AL, and Pepi M.
Abstract: Background - Computed tomography coronary angiography (cTCA) and stress cardiac magnetic resonance (stress-CMR) are suitable tools for diagnosing obstructive coronary artery disease in symptomatic patients with previous history of revascularization. However, performance appraisal of noninvasive tests must take in account the consequent diagnostic testing, invasive procedures, clinical outcomes, radiation exposure, and cumulative costs rather than their diagnostic accuracy only. We aimed to compare an anatomic (cTCA) versus a functional (stress-CMR) strategy in symptomatic patients with previous myocardial revascularization procedures. Methods and Results - Six hundred patients with chest pain and previous revascularization included in a prospective observational registry and evaluated by clinically indicated cTCA (n=300, mean age 68.2±9.7 years, male 255) or stress-CMR (n=300, mean age 67.6±9.7 years, male 263) were enrolled and followed-up in terms of subsequent noninvasive tests, invasive coronary angiography, revascularization procedures, cumulative effective radiation dose, major adverse cardiac events, defined as a composite end point of nonfatal myocardial infarction and cardiac death, and medical costs. The mean follow-up for cTCA and stress-CMR groups was similar (773.6±345 versus 752.8±291 days; P=0.21). Compared with stress-CMR, cTCA was associated with a higher rate of subsequent noninvasive tests (28% versus 17%; P=0.0009), invasive coronary angiography (31% versus 20%; P=0.0009), and revascularization procedures (24% versus 16%; P=0.007). Stress-CMR strategy was associated with a significant reduction of radiation exposure and cumulative costs (59% and 24%, respectively; P<0.001). Finally, patients undergoing stress-CMR showed a lower rate of major adverse cardiac events (5% versus 10%; P<0.010) and cost-effectiveness ratio (119.98±250.92 versus 218.12±298.45 Euro/y; P<0.001). Conclusions - Compared with cTCA, stress-CMR is more cost-effective
Published: 2016

32. Prognostic Benefit of Cardiac Magnetic Resonance over Transthoracic Echocardiography for the Assessment of Ischemic and Nonischemic Dilated Cardiomyopathy Patients Referred for the Evaluation of Primary Prevention Implantable Cardioverter-Defibrillator Therapy

Author: Pontone, G, Guaricci, A, Andreini, D, Solbiati, A, Guglielmo, M, Mushtaq, S, Baggiano, A, Beltrama, V, Fusini, L, Rota, C, Segurini, C, Conte, E, Gripari, P, Dello Russo, A, Moltrasio, M, Tundo, F, Lombardi, F, Muscogiuri, G, Lorenzoni, V, Tondo, C, Agostoni, P, Bartorelli, A, Pepi, M, Pontone G, Guaricci AI, Andreini D, Solbiati A, Guglielmo M, Mushtaq S, Baggiano A, Beltrama V, Fusini L, Rota C, Segurini C, Conte E, Gripari P, Dello Russo A, Moltrasio M, Tundo F, Lombardi F, Muscogiuri G, Lorenzoni V, Tondo C, Agostoni P, Bartorelli AL, Pepi M., Pontone, G, Guaricci, A, Andreini, D, Solbiati, A, Guglielmo, M, Mushtaq, S, Baggiano, A, Beltrama, V, Fusini, L, Rota, C, Segurini, C, Conte, E, Gripari, P, Dello Russo, A, Moltrasio, M, Tundo, F, Lombardi, F, Muscogiuri, G, Lorenzoni, V, Tondo, C, Agostoni, P, Bartorelli, A, Pepi, M, Pontone G, Guaricci AI, Andreini D, Solbiati A, Guglielmo M, Mushtaq S, Baggiano A, Beltrama V, Fusini L, Rota C, Segurini C, Conte E, Gripari P, Dello Russo A, Moltrasio M, Tundo F, Lombardi F, Muscogiuri G, Lorenzoni V, Tondo C, Agostoni P, Bartorelli AL, and Pepi M.
Abstract: Background - The aim of this study was to determine the prognostic benefit of cardiac magnetic resonance (CMR) over transthoracic echocardiography (TTE) in ischemic cardiomyopathy and nonischemic dilated cardiomyopathy patients evaluated for primary prevention implantable cardioverter-defibrillator therapy. Methods and Results - We enrolled 409 consecutive ischemic and dilated cardiomyopathy patients (mean age: 64±12 years; 331 men). All patients underwent TTE and CMR, and left ventricle end-diastolic volume, left ventricle end-systolic volume, and left ventricle ejection fraction (LVEF) were evaluated. In addition, late gadolinium enhancement was also assessed. All patients were followed up for major adverse cardiac events (MACE) defined as a composite end point of long runs of nonsustained ventricular tachycardia, sustained ventricular tachycardia, aborted sudden cardiac death, or sudden cardiac death. The median follow-up was 545 days. CMR showed higher left ventricle end-diastolic volume (mean difference: 43±22.5 mL), higher left ventricle end-systolic volume (mean difference: 34±20.5 mL), and lower LVEF (mean difference: -4.9±10%) as compared to TTE (P<0.01). MACE occurred in 103 (25%) patients. Patients experiencing MACE showed higher left ventricle end-diastolic volume, higher left ventricle end-systolic volume, and lower LVEF with both imaging modalities and higher late gadolinium enhancement per-patient prevalence as compared to patients without MACE. At multivariable analysis, CMR-LVEF ≤35% (hazard ratio=2.18 [1.3-3.8]) and the presence of late gadolinium enhancement (hazard ratio=2.2 [1.4-3.6]) were independently associated with MACE (P<0.01). A model based on CMR-LVEF ≤35% or CMR-LVEF ≤35% plus late gadolinium enhancement detection showed a higher performance in the prediction of MACE as compared to TTE-LVEF resulting in net reclassification improvement of 0.468 (95% confidence interval, 0.283-0.654; P<0.001) and 0.413 (95% confidence interval
Published: 2016

33. Outcomes in patients undergoing multivessel percutaneous coronary intervention using sirolimus-eluting stents: A report from the e-SELECT registry

Author: Cuculi, F, Banning, AP, Abizaid, A, Bartorelli, AL, Baux, AC, Džavík, V, Ellis, S, Gao, R, Holmes, D, Jeong, MH, Legrand, V, Neumann, FJ, Nyakern, M, Spaulding, C, Stoll, HP, Worthley, S, Urban, P, Chieffo, A, Naber, C, Jensen, LO, Sano, K, Srinivas, V., BARBATO, EMANUELE, Cuculi, F, Banning, Ap, Abizaid, A, Bartorelli, Al, Baux, Ac, Džavík, V, Ellis, S, Gao, R, Holmes, D, Jeong, Mh, Legrand, V, Neumann, Fj, Nyakern, M, Spaulding, C, Stoll, Hp, Worthley, S, Urban, P, Barbato, Emanuele, Chieffo, A, Naber, C, Jensen, Lo, Sano, K, and Srinivas, V.
Subjects: Registrie, Male, medicine.medical_treatment, Coronary, Infarction, Coronary Disease, heart disease, postoperative period, Coronary artery disease, coronary stent, Antibiotics, Sirolimu, Myocardial infarction, Registries, Angioplasty, Balloon, Coronary, Coronary Vessel, register, Antibiotics, Antineoplastic, diabetes mellitu, adult, article, Drug-Eluting Stents, Middle Aged, Antineoplastic, Coronary Vessels, surgical procedures, operative, female, Treatment Outcome, Drug-eluting stent, diabetes mellitus, Cardiology, Complex lesion, disease registry, treatment outcome, Aged, Cardiology and Cardiovascular Medicine, drug eluting stent, medicine.medical_specialty, heart infarction, prevalence, coronary artery dilatation, Internal medicine, Angioplasty, heart muscle revascularization, medicine, rapamycin, adult, Humans, controlled study, cardiovascular diseases, human, outcome assessment, Aged, Sirolimus, Sirolimus-eluting stent, business.industry, rapamycin, percutaneous coronary intervention, Percutaneous coronary intervention, medicine.disease, major clinical study, mortality, Surgery, Complex lesions, major adverse cardiac event, Conventional PCI, business, coronary artery disease, male, treatment outcome, Balloon, Female, Mace
Abstract: Aims: Performing percutaneous coronary intervention (PCI) to multiple coronary lesions during the same procedure has potential economic and social advantages. However comprehensive outcome data of real world practice in a large population is limited. We aimed to compare short- and long-term outcomes between patients with multi-vessel coronary artery disease who either underwent single- or multivessel PCI within the e-SELECT registry. Methods and results: The e-SELECT registry combines data collected at 320 medical centres in 56 countries where patients received CYPHER Select® or CYPHER Select® Plus sirolimus-eluting stent (SES). Rates of myocardial infarction and major adverse cardiac event (MACE) (defined as any death, myocardial infarction or target lesion revascularisation) were compared between patients undergoing single-vessel versus multivessel PCI. A total of 15,147 patients who satisfied the inclusion criteria were included in the e-SELECT registry. Two thousand two hundred and seventy-eight (2,278) subjects (15%) underwent multivessel PCI and 12,869 (85%) had single-vessel PCI. The mean age was higher in the multivessel PCI group (63 vs. 62 years, p
Published: 2011

34. Rapid Fire Abstract session: new insights in TAVI334Transcatheter heart valve underexpansion patterns335Echocardiography after TAVI with directflow medical prosthesis: small leaks and high gradients336Effects of transcatheter aortic valve implantation on left ventricular and atrial function evaluated by two and three-dimensional speckle tracking at eighteen-month follow-up337Impact of tricuspid regurgitation and right ventricular dysfunction on outcome of patients undergoing trans-catheter aortic valve replacement338Significant mitral regurgitation evolution in patients with severe aortic stenosis after transcatheter aortic valve implantation (TAVI): results and prognostic implications339An impact of pre- and postprocedural mitral regurgitation on mortality following TAVI340Immediate and one-year changes in systolic echocardiographic parameters after TAVI. Are there significant differences between patients with low and normal ejection fraction?341Long term echocardiographic follow-up (5-year) in transcatheter aortic valve implantation: morpho-functional changes of the implanted aortic valve: Table.

Author: Ren, B, primary, Sturmberger, T, primary, Ancona, R, primary, Schwartz, SL, primary, Del Val Martin, D, primary, Szymanski, P, primary, Islas, F, primary, Muratori, M, primary, Mcghie, J, additional, Van Weenen, S, additional, Rodriguez-Olivares, R, additional, Van Gils, L, additional, Geleijnse, ML, additional, De Jaegere, PPT, additional, Van Mieghem, NMDA, additional, Ebner, C, additional, Tkalec, W, additional, Eder, V, additional, Aichinger, J, additional, Comenale Pinto, S, additional, Caso, P, additional, Monteforte, I, additional, Coppola, MG, additional, Sellitto, V, additional, Macrino, M, additional, Ferro, A, additional, Calabro, R, additional, Rozenbaum, RZ, additional, Topilsky, Y, additional, Fraile Sanz, C, additional, Salido Tahoces, L, additional, Hernandez-Antolin, R, additional, Fernandez-Golfin, C, additional, Mestre Barcelo, JL, additional, Casas Rojo, E, additional, Zamorano Gomez, JL, additional, Hryniewiecki, T, additional, Jastrzebski, J, additional, Dabrowski, M, additional, Sorysz, D, additional, Kochman, J, additional, Kukulski, T, additional, Zembala, M, additional, Almeria, C, additional, Olmos, C, additional, Garcia, E, additional, Nombela, L, additional, Marcos-Alberca, P, additional, De Agustin, JA, additional, Mahia, P, additional, Macaya, C, additional, Perez De Isla, L, additional, Fusini, L, additional, Ghulam Ali, S, additional, Tamborini, G, additional, Gripari, P, additional, Salvi, L, additional, Bartorelli, AL, additional, Alamanni, F, additional, and Pepi, M, additional
Published: 2015
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35. Poster session 5The imaging examinationP1097Correlation between visual and quantitative assessment of left ventricle: intra- and inter-observer agreementP1099Incremental prognostic value of late gadolinium-enhanced by cardiac magnetic resonance in patients with heart failureAnatomy and physiology of the heart and great vesselsP1100Left ventricular geometry and diastolic performance in erectile dysfunction patients; a topic of differential arterial stiffness influenceAssessment of diameters, volumes and massP1101Impact of the percutaneous closure of atrial septal defect on the right heart "remodeling"P1102Left Ventricular Mass Indexation in Infants, Children and Adolescents: a Simplified Approach for the Identification of Left Ventricular Hypertrophy in Clinical PracticeP1103Impact of trabecules while quantifying cardiac magnetic resonance exams in patients with systemic right ventricleP1104Detection of subclinical atherosclerosis by carotid intima-media thickness: correlation with leukocytes telomere shorteningAssessments of haemodynamicsP1105Flow redirection towards the left ventricular outflow tract: vortex formation is not affected by variations in atrio-ventricular delayAssessment of systolic functionP1106Reproducibility and feasibility of cardiac MRI feature tracking in Fabry diseaseP1107Normal left ventricular strain values by two-dimensional strain echocardiography; result of normal (normal echocardiographic dimensions and functions in korean people) studyP1108Test-retest repeatability of global strain following st-elevation myocardial infarction - a comparison of tagging and feature trackingP1109Cardiotoxicity induced by tyrosine kinase inhibitors in patients with gastrointestinal stromal tumors (GIST)P1110Finite strain ellipses for the analysis of left ventricular principal strain directions using 3d speckle tracking echocardiographyP1111Antihypertensive therapy reduces time to peak longitudinal strainP1112Right ventricular systolic function as a marker of prognosis after inferior myocardial infarction - 5-year follow-upP1113Is artery pulmonary dilatation related with right but also early left ventricle dysfunction in pulmonary artery hypertension?P1114Right ventricular mechanics changes according to pressure overload increasing, a 2D-speckle tracking echocardiographic evaluationAssessment of diastolic functionP1115Paired comparison of left atrial strain from P-wave to P-wave and R-wave to R-waveP1116Diagnostic role of Tissue Doppler Imaging echocardiographic criteria in obese heart failure with preserved ejection fraction patientsP1117Evaluation of diastolic function of right ventricle in idiopathic pulmonary arterial hypertensionP1118Severity and predictors of diastolic dysfunction in a non-hypertensive non-ischemic cohort of Egyptian patients with documented systemic autoimmune disease; pilot reportP1119correlation between ST segment shift and cardiac diastolic function in patients with acute myocardial infarctionIschemic heart diseaseP1120Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)P1121Utility of transmural myocardial mechanic for early infarct size prediction after primary percutaneous coronary intervention in STEMI patientsP1122Progressive Improvements of the echocardiographic deformation parameters in ST Elevation Myocardial Infarction after five years follow-upP1123Long-term prognostic value of left ventricular dyssynchrony as assessed by cardiac magnetic resonance feature-tracking imaging after a first st-segment elevation myocardial infarctionP1124Differences in mitral annulus remodeling in acute anterior ST elevation and acute inferior ST elevation myocardial infarctionP1125Reduction of microvascular injury using a novel theragnostic ultrasound strategy: a first in men feasibility and safety studyP1126Impact of focused echocardiography in clinical decision of patient presented with st elevation myocardial infarction underwent primary angioplastyHeart valve DiseasesP1127Aortic valve area calculation in aortic stenosis: a comparison among conventional and 3D-transesophageal echocardiography and computed tomographyP1128Myocardial fibrosis and microRNA-21 expression in patients with severe aortic valve stenosis and preserved ejection fraction: a 2D speckle tracking echocardiography, tissutal and plasmatic studyP1129Quantification of calcium amount in a new experimental model: a comparison between calibrated integrated backscatter of ultrasound and computed tomographyP1130Altered diffusion capacity in aortic stenosis: role of the right heartP1131Osteoprotegerin predicts all-cause mortality in calcific aortic stenosis patients with preserved left ventricle ejection fraction in long term observationP1132Mitral regurgitation as a risk factor for pulmonary hypertension in patients with aortic stenosisP1133The relationship between the level of plasma B-type natriuretic peptide and mitral stenosisP1134Aortic regurgitation, left ventricle mechanics and vascular load: a single centre 2d derived-speckle tracking studyP1135Feasibility and reproducibility issues limit the usefulness of quantitative colour Doppler parameters in the assessment of chronic aortic and mitral regurgitation severityP1136Predictors of postoperative outcome in degenerative mitral regurgitationP1137Left ventricular mechanical dyssynchrony in patients with severe mitral regurgitation of rheumatic etiology; three dimensional echocardiography studyP1138Functional mitral regurgitation and left atrial dysfunction concur in determining pulmonary hypertension and functional status in subjects with left ventricular systolic dysfunctionP11393D echocardiography allows more effective quantitative assessment of the severity of functional tricuspid regurgitation than conventional 2D/Doppler echocardiographyP1140Prosthetic valve thrombosis: still a severe disease? 10-years experience in a university hospitalP1141Validity of echocardiography in the hospital course of patients with feverP1142Do baseline 3DTEE characteristics of mitral valve apparatus predict long term result in patients undergoing percutaneous valve repair for degenerative regurgitation?P1143Influence of baseline aortic regurgitation on mitral regurgitation change after transcatheter aortic valve replacement for aortic stenosisP1144Prevalence of echocardiography detected significant valvular regurge in subclinical rheumatic carditis in assiut childrenCardiomyopathiesP1145Can we early detect left ventricular systolic dysfunction in patients with Duchenne muscular dystrophy using global longitudinal strain assessment?P1146Prevalence of isolated papillary muscle hypertrophy in young competitive athletesP1147Troponin release after exercise in patients with hypertrophic cardiomyopathy: associations with clinical and mr imaging characteristicsP1148Atrial fibrillation in hypertrophic cardiomyopathy: can we score the risk?P1149Impact of hypertrophy on multiple layer longitudinal deformation in hypertrophy cardiomyopathy and cardiac amyloidosis compared to controlsP1150Functional evaluation in hypertrophic cardiomyopathy combining cardiopulmonary exercise testing combined with exercise-echocardiographyP1151Refinement of the old diagnostic criteria of left ventricular noncompaction cardiomyopathy (LVNC) based on cardiac magnetic resonance (CMR)P1152Differences of clinical characteristics and outcomes between acute myocarditis with preserved and reduced left ventricular systolic functionP1153Value of longitudinal strain for distinguishing left ventricular non-compaction from idiopathic dilated cardiomyopathyP1154Speed of recovery of left ventricular function is not related to the prognosis of Takotsubo cardiomyopathy. A Portuguese multicentre studyP1155Predictors of in-hospital left ventricular systolic function recovery after admission with takotsubo cardiomyopathy. Portuguese multicentre studyP1156Mid-ventricular takotsubo detected by initial echocardiogram associates with recurrence of takotsubo cardiomyopathy - a portuguese multicentre studySystemic diseases and other conditionsP1157Relations between left ventricle remodelling and expression of angiotensin 2 AT2R1 geneP1158Impact of renal denervation on long-term blood pressure variability and surrogate markers of target organ damage in individuals with drug-resistant arterial hypertensionP1159Greater improvement of coronary artery function, left ventricular deformation and twisting by IL12/23 compared to TNF-a inhibition in psoriasisP1160Advanced glycation end products play a role in adverse LV remodeling following MIP1161Incidence of subclinical myocardial dysfunction in patients with systemic sclerosis and normal left ventricular systolic and diastolic functionP1162Left atrial remodeling and dysfunction occur early in patients with systemic sclerosis and normal left ventricular functionP1163Intrinsic vortex formation : a unique performance indicatorP1164P-wave morphology is unaffected by training-induced biatrial dilatation: a prospective, longitudinal study in healthy athletesP1165Usefulness of transthoracic echocardiography in diagnosis of young patients with ischemic strokeP1166Primary cardiac lymphoma: role of echocardiography in the clinical managementP1167Abnormal echocardiographic findings in cancer patients before chemotherapyMasses, tumors and sources of embolismP1168Three-dimensional transesophageal echocardiography of the left atrial appendage reduces rate of postpone electrical cardioversionP1169Detection of ventricular thrombus by cmr after reperfused st-segment elevation myocardial infarction correlated with echocardiographyP1170Clinical and transthoracic echocardiographic predictors of left atrial appendage thrombus in patients with atrial fibrillationStress echocardiographyP1171Pharmacological stress echocardiography complications: a 4-year single center experienceP1172Myocardial functional and perfusion reserve in type I diabetesP1173Feasibility of incorporating 3D Dobutamine stress echocardiography into routine clinical practiceP1174Right ventricular isovolumic acceleration at rest and during exercise in children after heart transplantP1175Right ventricular systolic and diastolic response to exercise in children after heart transplant -a bicycle exercise studyP1176Determinants of functional capacity in heart failure patients with reduced ejection fractionP1177Handgrip stress echocardiography with emotional component compared to conventional isometric exercise in coronary artery disease diagnosisP1178The relationship between resting transthoracic echocardiography and exercise capacity in patients with paroxysmal atrial fibrillationP1179Correlation between NT-proBNP and selected echocardiography parameters at rest and after exercise in patients with functional ischemic mitral regurgitation qualified for cardiosurgical treatmentReal-time three-dimensional TEEP1180Vena contracta area for severity grading in functional and degenerative mitral regurgitation: A study based on transesophageal 3D colour Doppler in 419 patientsP1181Proximal flow convergence by 3D echocardiography in the evaluation of mitral valve area in rheumatic mitral stenosisP1182Quantification of valve dimensions by transesophageal 3D echocardiography in patients with functional and degenerative mitral regurgitationTissue Doppler and speckle trackingP1183Automatic calculation of left ventricular volume changes over a cardiac cycle from echocardiography images by nonlinear dimensionality reductionP1184Effect of the mitral valve repairs on the left ventricular blood flow formationP1185Quantification of left atrial strain using cardiovascular magnetic resonance. a comparison between hypertrophic cardiomyopathy and healthy controlsP1186The role of early systolic lengthening in patients with non-ST elevation acute coronary syndrome and its relation to syntax scoreP1187Different standard two dimensional strain methods to quantity left ventricular mechanicsP1188Atrial function and electrocardiography caracteristics in sportsmen with or without paroxysmal atrial fibrillationP1189Right ventricular outflow premature contractions induce regional left ventricular dysfunctionP1190Ultrasound guided venous access for pacemaker and defibrillators. Randomized TrialP1191Atrial function analysis correlates with symptoms and quality of life of heart failure patientsP1192The use of tissue doppler echocardiography in myocardial iron overload in patients with thalassaemia majorP1193Independent association between pulse pressure and left ventricular global longitudinal strainP1194Global and regional longitudinal strain identifies the presence of coronary artery disease in patients with suspected reduction of coronary flow reserve and absence of wall motion abnormalitiesP1195Prognostic value of invasive and noninvasive parameters of right ventricular function in patients with pulmonary arterial hypertension receiving specific vasodilator therapyP1196Myocardial deformation analysis to improve arrhythmic risk stratificationP1197Quantitative assessment of regional systolic and diastolic function parameters for detecting prior transient ischemia in normokinetic segmentsP1198Left atrial function in patients with corrected tetralogy of Fallot - a three-dimensional speckle-tracking echocardiographic studyP1199Left atrial ejection force correlates with left atrial strain and volume-based functional properties as assessed by three-dimensional speckle tracking echocardiographyP1200Acute angulation of the aortic arch late after the arterial switch operation for transposition of the great arteries: impact on cardiac mechanicsP1201Circumferential deformation of the ascending thoracic aorta in hypertensive patients by three-dimensional speckle tracking echocardiographyCardiac Magnetic ResonanceP1202The incremental value of cardiac magnetic resonance on diagnosis myocardial infarction and non-obstructed coronary arteriesP1204Reference ranges of global and regional myocardial T1 values derived from MOLLI and shMOLLI at 3TComputed Tomography & Nuclear CardiologyP1205Deformation of the left atrial appendage after percutaneous closure with the Amplatzer cardiac plugP1206Prognostic impact of non-obstructive coronary artery disease on coronary computed tomographic angiography: A single-center study

Author: Colunga Blanco, S, primary, Gonzalez Matos, C, primary, Angelis, A, primary, Dinis, P G, primary, Chinali, M, primary, Toth, A, primary, Andreassi, M G, primary, Rodriguez Munoz, D, primary, Reid, A B, primary, Park, JH, primary, Shetye, A, primary, Novo, G, primary, De Marchi, S F, primary, Cikes, M, primary, Smarz, K, primary, Illatopa, V, primary, Peluso, D, primary, Wellnhofer, E, primary, De La Rosa Riestra, A, primary, Sattarzadeh Badkoubeh, R, primary, Mandour Ali, M, primary, Azoz, A, primary, Pontone, G, primary, Krljanac, G, primary, Acar, R, primary, Nucifora, G, primary, Sirtautas, A, primary, Roos, S T, primary, Qasem, M S, primary, Marini, C, primary, Fabiani, I, primary, Gillis, K, primary, Bandera, F, primary, Borowiec, A, primary, Lim, YJ, primary, Chalbia, T E, primary, Santos, M, primary, Gao, S A, primary, Zilberszac, R, primary, Farrag, AAM, primary, Palmiero, G, primary, Aruta, P, primary, De Diego Soler, O, primary, Fasano, D, primary, Tamborini, G, primary, Ancona, F, primary, Raafat, D M, primary, Marchel, M, primary, De Gregorio, C, primary, Gommans, D H F, primary, Godinho, A R, primary, Mielczarek, M, primary, Kubik, M, primary, Cho, J Y, primary, Tarando, F, primary, Lourenco Marmelo, B F, primary, Reis, L, primary, Domingues, K, primary, Krestjyaninov, MV, primary, Mesquita, J, primary, Ikonomidis, I, primary, Ferferieva, V, primary, King, GJ, primary, D'ascenzi, F, primary, Ferrera Duran, C, primary, Sormani, P, primary, Gonzalez Fernandez, O, primary, Tereshina, O, primary, Cambronero Cortinas, E, primary, Kupczynska, K, primary, Carvalho, J F, primary, Shivalkar, B, primary, Aghamohammadzadeh, R, primary, Cifra, B, primary, Kuznetsov, VA, primary, Van Zalen, JJ, primary, Kochanowski, J, primary, Goebel, B, primary, Ladeiras-Lopes, R, primary, Karvandi, M, primary, Alonso Salinas, G, primary, Unkun, T, primary, Ranjbar, S, primary, Hubert, A, primary, Enescu, OA, primary, Liccardo, M, primary, Cameli, M, primary, Ako, E, primary, Lembo, M, primary, Goffredo, C, primary, Enache, R, primary, Wdowiak-Okrojek, K, primary, Nemes, A, primary, Di Salvo, G, primary, Capotosto, L, primary, Caravaca, P, primary, Maceira Gonzalez, A M, primary, Iriart, X, primary, Jug, B, primary, Garcia Campos, A, additional, Capin Sampedro, E, additional, Corros Vicente, C, additional, Martin Fernandez, M, additional, Leon Arguero, V, additional, Fidalgo Arguelles, A, additional, Velasco Alonso, E, additional, Lopez Iglesias, F, additional, De La Hera Galarza, JM, additional, Chaparro-Munoz, M, additional, Recio-Mayoral, A, additional, Vlachopoulos, C, additional, Ioakeimidis, N, additional, Felekos, I, additional, Abdelrasoul, M, additional, Aznaouridis, K, additional, Chrysohoou, C, additional, Rousakis, G, additional, Aggeli, K, additional, Tousoulis, D, additional, Faustino, AC, additional, Paiva, L, additional, Fernandes, A, additional, Costa, M, additional, Cachulo, MC, additional, Goncalves, L, additional, Emma, F, 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additional, Acar, R, additional, Bakal, RB, additional, Kaymaz, C, additional, Karvandi, M, additional, Galand, V, additional, Matelot, D, additional, Leclercq, C, additional, Carre, F, additional, Suran, BC, additional, Margulescu, AD, additional, Rimbas, RC, additional, Siliste, C, additional, Vinereanu, D, additional, Nocerino, P, additional, Urso, AC, additional, Borrino, A, additional, Carbone, C, additional, Follero, P, additional, Ciardiello, C, additional, Prato, L, additional, Salzano, G, additional, Marino, F, additional, Ruspetti, A, additional, Sparla, S, additional, Di Tommaso, C, additional, Loiacono, F, additional, D'ascenzi, F, additional, Porter, J, additional, Walker, M, additional, Lo Iudice, F, additional, Esposito, R, additional, Santoro, C, additional, Cocozza, S, additional, Izzo, R, additional, De Luca, N, additional, De Simone, G, additional, Trimarco, B, additional, Galderisi, M, additional, Gervasi, F, additional, Patti, G, additional, Mega, S, additional, 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Ropero, MJ, additional, Izquierdo Bajo, A, additional, Madrona, L, additional, Monmeneu, JV, additional, Igual, B, additional, Lopez Lereu, P, additional, Garcia, MP, additional, Selmi, W, additional, Jalal, Z, additional, Thambo, JB, additional, Kosuta, D, additional, and Fras, Z, additional
Published: 2015
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36. Acute procedural and six-month clinical outcome in patients treated with a dedicated bifurcation stent for left main stem disease: the TRYTON LM multicentre registry

Author: Magro, M, Girasis, C, Bartorelli, Al, Tarantini, Giuseppe, Russo, F, Trabattoni, D, D'Amico, G, Galli, M, Gómez Juame, A, de Sousa Almeida, M, Simsek, C, Foley, D, Sonck, J, Lesiak, M, Kayaert, P, Serruys, Pw, van Geuns RJ, D'Amico, Gianpiero, Cardiology, and Radiology & Nuclear Medicine
Subjects: Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Myocardial Infarction, Coronary Artery Disease, Balloon, Coronary Angiography, Prosthesis Design, Predictive Value of Tests, medicine, Humans, In patient, Everolimus, Registries, Angioplasty, Balloon, Coronary, Left main stem disease, Aged, Retrospective Studies, Sirolimus, business.industry, Unstable angina, Stent, Cardiovascular Agents, Drug-Eluting Stents, Middle Aged, medicine.disease, Surgery, Europe, Treatment Outcome, Bypass surgery, Conventional PCI, Female, Stents, Radiology, Cardiology and Cardiovascular Medicine, business, Mace
Abstract: Aims: Tryton side branch (SB) reverse culotte stenting has been employed for the treatment of left main (LM) stem bifurcations in patients at high risk for bypass surgery. The aim of this study was to assess acute angiographic results and six-month clinical outcome after implantation of the Tryton stent in the LM. Methods and results: We studied 52 consecutive patients with LM disease treated in nine European centres. Angiographic and clinical data analysis was performed centrally. Fifty-one of 52 patients (age 68±11 yrs, 75% male, 42% unstable angina, SYNTAX score 20±8) were successfully treated with the Tryton stent. Medina class was 1,1,1 in 33 (63%), 1,0,1 in 7 (13%), 1,1,0 in 3 (6%), 0,1,1 in 8 (4%) and 0,0,1 in 1 (2%). The Tryton stent on a stepped balloon (diameter 3.5-2.5 mm) was used in 41/51 (80%) of cases. The mean main vessel stent diameter was 3.4±0.4 mm with an everolimus-eluting stent employed in 30/51 (59%) of cases. Final kissing balloon dilatation was performed in 48/51 (94%). Acute gain was 1.52±0.86 mm in the LM and 0.92±0.47 mm in the SB. The angiographic success rate was 100%; the procedural success rate reached 94%. Periprocedural MI occurred in three patients. At six-month follow-up, the TLR rate was 12%, MI 10% and cardiac death 2%. The hierarchical MACE rate at six months was 22%. No cases of definite stent thrombosis occurred. Conclusions: The use of the Tryton stent for treatment of LM bifurcation disease in combination with a conventional drug-eluting stent is feasible and achieves an optimal angiographic result. Safety of the procedure and six-month outcome are acceptable in this high-risk lesion PCI. Further safety and efficacy studies with long-term outcome assessment of this strategy are warranted.
Published: 2013

37. Marco Giorgio Marco Giorgio Circulating cytochrome c is a new candidate biomarker of reperfusion injury in ST-segment elevation acute myocardial infarction

Author: Marenzi, G, Giorgio, M, Trinei, M, Moltrasio, M, Ravagnani, P, D Cardinale D, Ciceri, F, Cavallero, A, Cipolla, Cm, and AL Bartorelli AL
Published: 2009

38. Angiographic findings of the multicenter randomized study with the sirolimus-eluting Bx velocity balloon-expandable stent (RAVEL): Sirolimus-eluting stents inhibit restenosis irrespective of the vessel size

Author: Regar, Evelyn, Serruys, PWJC (Patrick), Bode, C, Holubarsch, C, Guermonprez, JL, Wijns, W (William), Bartorelli, AL, Constantini, C, Degertekin, M, Tanabe, K, Disco, C, Wuelfert, E, Morice, MC, Regar, Evelyn, Serruys, PWJC (Patrick), Bode, C, Holubarsch, C, Guermonprez, JL, Wijns, W (William), Bartorelli, AL, Constantini, C, Degertekin, M, Tanabe, K, Disco, C, Wuelfert, E, and Morice, MC
Published: 2002

39. Assessment of myocardial perfusion and viability with technetium-99m methoxyisobutylisonitrile and thallium-201 rest redistribution in chronic coronary artery disease

Author: Rossetti, C, Landoni, C, Lucignani, G, Huang, G, Bartorelli, A, Guazzi, M, Margonato, A, Chierchia, S, Galli, L, Savi, A, Fazio, F, LANDONI, CLAUDIO, Bartorelli, AL, Guazzi, MD, FAZIO, FERRUCCIO, Rossetti, C, Landoni, C, Lucignani, G, Huang, G, Bartorelli, A, Guazzi, M, Margonato, A, Chierchia, S, Galli, L, Savi, A, Fazio, F, LANDONI, CLAUDIO, Bartorelli, AL, Guazzi, MD, and FAZIO, FERRUCCIO
Abstract: We compare thallium-201 rest redistribution and fluorine-18 fluorodeoxyglucose ([18F]FDG) for the assessment of myocardial viability within technetium-99m methoxyisobutylisonitrile (MIBI) perfusion defects in 27 patients with chronic stable coronary artery disease. The following studies were performed: (1) stress 99mTc-MIBI, (2) rest 99mTc-MIBI, (3) 201Tl rest-redistribution single-photon emission tomography, (4) [18F]FDG positron emission tomography. The left ventricle was devided into 11 segments on matched tomographic images. The segment with the highest activity at stress was taken as the reference (activity=100%). Perfusion defects at 99mTc-MIBI rest were classified as severe (activity<50%), moderate (activity 50%-60%) or mild (activity 60%-85%). Uptakes of [18F]FDG and rest-redistributed 201Tl were recognized as significant if they exceeded 50% of that in the reference segment. Among the 33 segments with severe 99mTc-MIBI rest perfusion defects, 21 had significant [18F]FDG and 10 significant rest-redistributed 201Tl uptake. As regards the 37 segments with moderate defects, [18F]FDG was present in 29 and 201Tl in 31, while of the 134 segments with mild defects, 128 showed [18F]FDG uptake, and 131, 201Tl uptake. In conclusion, there is an inverse relationship between the severity of 99mTc-MIBI perfusion defects and the uptake of rest-redistributed 201Tl and [18F]FDG. Both tracers are adequate markers of viability in mild and moderate defects; in severe defects 201Tl might underestimate the presence of viability as assessed by [18F]FDG.
Published: 1995

40. Aortic annulus area assessment by multidetector computed tomography for predicting paravalvular regurgitation in patients undergoing balloon-expandable transcatheter aortic valve implantation: a comparison with transthoracic and transesophageal...

Author: Pontone G, Andreini D, Bartorelli AL, Bertella E, Cortinovis S, Mushtaq S, Annoni A, Formenti A, Baggiano A, Conte E, Tamborini G, Muratori M, Gripari P, Bovis F, Veglia F, Foti C, Alamanni F, Ballerini G, Fiorentini C, and Pepi M
Abstract: Background: Transcatheter aortic valve implantation (TAVI) is a valid alternative to surgery in high-risk patients with severe aortic stenosis. Aortic annulus (AoA) sizing is crucial for TAVI success. The aim of the study was to compare AoA dimensions measured by multidetector computed tomography (MDCT) vs those obtained with transthoracic (TTE) and transesophageal echocardiography (TEE) for predicting paravalvular aortic regurgitation (PVR) after TAVI. Methods: Aortic annulus maximum diameter, minimum diameter, and area were assessed using MDCT and compared with TTE and TEE diameter and area for predicting PVR after TAVI in 151 patients (45 men, age 81.2 ± 6.4 years). Results: Aortic annulus maximum, minimum diameter, and area detected by MDCT were 25.04 ± 2.39 mm, 21.27 ± 2.10 mm, and 420.87 ± 76.10 mm(2), respectively. Aortic annulus diameter and area measured by TTE and TEE were 21.14 ± 1.94 mm and 353.82 ± 64.57 mm(2) and 22.04 ± 1.94 mm and 384.33 ± 67.30 mm(2), respectively. A good correlation was found between AoA diameters and area evaluated by MDCT vs TTE and TEE (0.61, 0.65, and 0.69 and 0.61, 0.65, and 0.70, respectively), with a mean difference of 3.90 ± 1.98 mm, 0.13 ± 1.67 mm, and 67.05 ± 55.87 mm(2) and 3.0 ± 2.0 mm, 0.77 ± 1.70 mm, and 36.54 ± 56.43 mm(2), respectively. Grade ≥2 PVR occurred in 46 patients and was related to male gender, higher body mass index, preprocedural aortic regurgitation, and lower mismatch between the nominal area of the implanted prosthesis and AoA area detected by MDCT. Conclusions: Mismatch between prosthesis area and AoA area detected by MDCT is a better predictor of PVR as compared with echocardiography mismatch. Specific MDCT-based sizing recommendations should be developed. [ABSTRACT FROM AUTHOR]
Published: 2012
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41. A new kaolin-based haemostatic bandage compared with manual compression for bleeding control after percutaneous coronary procedures.

Author: Trabattoni D, Montorsi P, Fabbiocchi F, Lualdi A, Gatto P, Bartorelli AL, Trabattoni, Daniela, Montorsi, Piero, Fabbiocchi, Franco, Lualdi, Alessandro, Gatto, Pamela, and Bartorelli, Antonio L
Abstract: Objective: Bleeding and vascular access site complications are an important cause of morbidity after percutaneous femoral procedures. New haemostatic dressings have been developed to control heavy bleeding. To evaluate the efficacy of a new kaolin-based haemostatic bandage for femoral artery closure after diagnostic or interventional procedures compared with manual compression.Methods: The first pilot European trial using this haemostatic bandage was performed at the in Milan, Italy. Two-hundred patients (71% male, mean age 66 ± 11 years) undergoing angiography or PCI via a femoral approach were randomised to the haemostatic bandage (n = 100) or manual compression (n = 100) following sheath removal. The mean active clotting time (ACT) at haemostasis was 146 ± 24 s (range 98-198 s). Haemostasis was achieved in 5.4 ± 1.5 min with the bandage vs 25 ± 15 min after manual compression, p < 0.001. No haemostasis failure occurred in either group. No differences in oozing, minor and major haematomas and pseudoaneurysms were observed. All patients ambulated at 4 h. Major bleeding, re-bleeding or haematoma did not occur after early (4 h after the procedure) ambulation following use of the bandage.Conclusions: The haemostatic bandage obtained prompt and significantly shorter haemostasis than controls. This novel haemostatic device allowed for early ambulation without clinical complications. [ABSTRACT FROM AUTHOR]
Published: 2011
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42. High diagnostic accuracy of prospective ECG-gating 64-slice computed tomography coronary angiography for the detection of in-stent restenosis: in-stent restenosis assessment by low-dose MDCT.

Author: Andreini D, Pontone G, Bartorelli AL, Mushtaq S, Trabattoni D, Bertella E, Cortinovis S, Annoni A, Formenti A, Ballerini G, Agostoni P, Fiorentini C, Pepi M, Andreini, Daniele, Pontone, Gianluca, Bartorelli, Antonio L, Mushtaq, Saima, Trabattoni, Daniela, Bertella, Erika, and Cortinovis, Sarah
Abstract: Objectives: The accuracy of computed tomography (CT) for assessment of coronary stents is as yet unproven and radiation exposure has been a concern. The aim of our study is to compare radiation dose and diagnostic performance of CT with prospective ECG-triggering versus retrospective ECG-triggering for the detection of in-stent restenosis (ISR).Methods: We enrolled 168 consecutive patients with suspected ISR, 83 studied using CT with prospective ECG-triggering (group 1) and 85 using retrospective ECG-triggering (group 2).Results: Prevalence of ISR according to catheter angiography was 24% in both groups. The overall evaluability was similar (93% in group 1 vs 95% in group 2). Artefact sub-analysis showed a significantly lower number of blooming and higher number of slice misalignment in group 1 vs group 2. In the stent-based analysis using only evaluable stents, specificity, positive predictive value and accuracy were significantly higher in group 1 (100%, 100% and 99%, respectively) than in group 2 (97%, 91% and 95%, respectively, p < 0.05). Group 1 was exposed to a lower radiation dose compared with group 2 (4.3 ± 1.4 mSv vs 18.5 ± 5.5 mSv, p < 00.1).Conclusions: CT with prospective ECG-triggering can improve diagnostic accuracy of non-invasive imaging of coronary stents with a significant reduction in radiation exposure. [ABSTRACT FROM AUTHOR]
Published: 2011
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43. Carotid stenting through the right brachial approach for left internal carotid artery stenosis and bovine aortic arch configuration.

Author: Montorsi P, Galli S, Ravagnani P, Ghulam Ali S, Trabattoni D, Fabbiocchi F, Lualdi A, Ballerini G, Andreini D, Pontone G, Annoni A, Bartorelli AL, Montorsi, Piero, Galli, Stefano, Ravagnani, Paolo, Ghulam Ali, Sarah, Trabattoni, Daniela, Fabbiocchi, Franco, Lualdi, Alessandro, and Ballerini, Giovanni
Abstract: Unfavorable complex anatomy or congenital anomalies of supra-aortic vessel take-off may increase carotid artery stenting (CAS) procedural difficulties and complications through the femoral route. We assessed the feasibility, safety, and efficacy of CAS through the right brachial approach in patients in whom left internal carotid artery stenosis and bovine aortic arch configuration were identified with computed tomography (CT) angiography. Bovine configuration of the aortic arch and left carotid artery stenosis were easily identified by CT angiography and successfully treated through the right brachial approach technique. [ABSTRACT FROM AUTHOR]
Published: 2009
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44. Randomized evaluation of polytetrafluoroethylene-covered stent in saphenous vein grafts: the Randomized Evaluation of polytetrafluoroethylene COVERed stent in Saphenous vein grafts (RECOVERS) Trial.

Author: Stankovic G, Colombo A, Presbitero P, van den Branden F, Inglese L, Cernigliaro C, Niccoli L, Bartorelli AL, Rubartelli P, Reifart N, Heyndrickx GR, Saunamäki K, Morice MC, Sgura FA, Di Mario C, and RECOVERS (Randomized Evaluation of polytetrafluoroethylene COVERed stent in Saphenous vein grafts) Investigators
Published: 2003

45. Rapid Fire Abstract session: new insights in TAVI

Author: Ren, B, Mcghie, J, Van Weenen, S, Rodriguez-Olivares, R, Van Gils, L, Geleijnse, ML, De Jaegere, PPT, Van Mieghem, NMDA, Sturmberger, T, Ebner, C, Tkalec, W, Eder, V, Aichinger, J, Ancona, R, Comenale Pinto, S, Caso, P, Monteforte, I, Coppola, MG, Sellitto, V, Macrino, M, Ferro, A, Calabro, R, Schwartz, SL, Rozenbaum, RZ, Topilsky, Y, Del Val Martin, D, Fraile Sanz, C, Salido Tahoces, L, Hernandez-Antolin, R, Fernandez-Golfin, C, Mestre Barcelo, JL, Casas Rojo, E, Zamorano Gomez, JL, Szymanski, P, Hryniewiecki, T, Jastrzebski, J, Dabrowski, M, Sorysz, D, Kochman, J, Kukulski, T, Zembala, M, Registry, POL-TAVI, Islas, F, Almeria, C, Olmos, C, Garcia, E, Nombela, L, Marcos-Alberca, P, De Agustin, JA, Mahia, P, Macaya, C, Perez De Isla, L, Muratori, M, Fusini, L, Ghulam Ali, S, Tamborini, G, Gripari, P, Salvi, L, Bartorelli, AL, Alamanni, F, and Pepi, M
Abstract: Background: The size of the transcatheter heart valves (THV) is overestimated up to 20% based on aortic annulus diameter measured using computed tomography (CT). However, the prosthesis may not be fully expanded during implantation. THV underexpansion might have detrimental clinical consequences. Purpose The aim of this study was to define the degree of underexpansion degree of different THVs after implantation, introduced as the shrinking index. Methods: In total we enrolled 114 patients (68 men, 79 ± 8 years old) who underwent transcatheter aortic valve implantation (TAVI) with the self-expanding CoreValve (n=28 patients), mechanically expanded Lotus valve (n= 37) or balloon expandable Edwards SAPIEN XT (n=18) and Edwards SAPIEN 3 (n= 31). The cover index of the THV was calculated as the percentage difference of the nominal prosthesis size and annulus diameter measured using CT. Intraprocedural transesophageal echocardiography (TEE) was performed to determine the size of the THV inflow after implantation. The shrinking index was calculated as the percentage of the difference between the inflow size by TEE and the nominal prosthesis size divided by prosthesis size. Results: Cover index per CT assessment before TAVI was 18 ± 7% for CoreValve, 2 ± 4% for Lotus, 9 ± 5% for Edwards SAPIEN and 4 ± 5% for Edwards SAPIEN 3 (ANOVA p < 0.001, Corevalve was significantly larger than the others). Compared with aortic annulus diameter measured using TEE in long axis view, the overestimation increased to 28 ± 9% for CoreValve, 12 ± 8% for Lotus, 18 ± 12% for Edwards SAPIEN and 12 ± 8% for Edwards SAPIEN 3 (ANOVA p < 0.001, Corevalve was significantly larger than the others). Conversely, the shrinking index after TAVI was -31 ± 6% for CoreValve, -20 ± 5% for Lotus, -22 ± 6% for SAPIEN XT and -19 ± 5% for SAPIEN 3 (ANOVA p < 0.001, Corevalve was significantly larger than the others). The interobserver variability (relative difference) of TEE in measuring the aortic annulus and prosthesis inflow was 6 ± 5% and 7 ± 5% respectively. Conclusion: The shrinking index determines the degree of THV underexpansion after TAVI and can be reliably measured with TEE. The self-expanding CoreValve tended to be under-expanded the most, indicated by the largest shrinking index, while the under-expansion degree was comparable between Lotus valve, SAPIEN XT and SAPIEN 3. The clinical implications of the shrinking index requires further study.
Published: 2015
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46. Poster session 5

Author: Colunga Blanco, S, Garcia Campos, A, Capin Sampedro, E, Corros Vicente, C, Martin Fernandez, M, Leon Arguero, V, Fidalgo Arguelles, A, Velasco Alonso, E, Lopez Iglesias, F, De La Hera Galarza, JM, Gonzalez Matos, C, Chaparro-Munoz, M, Recio-Mayoral, A, Angelis, A, Vlachopoulos, C, Ioakeimidis, N, Felekos, I, Abdelrasoul, M, Aznaouridis, K, Chrysohoou, C, Rousakis, G, Aggeli, K, Tousoulis, D, Dinis, P G, Faustino, AC, Paiva, L, Fernandes, A, Costa, M, Cachulo, MC, Goncalves, L, Chinali, M, Emma, F, Rinelli, G, Esposito, C, Franceschini, A, Doyon, A, Raimondi, F, Schaefer, F, Pongiglione, G, Mateucci, MC, Toth, A, Vago, H, Juhasz, C, Janosa, C, Oprea, V, Balint, OH, Temesvari, A, Simor, T, Kadar, K, Merkely, B, Andreassi, M G, Bruno, R M, Borghini, A, Stea, F, Gargani, L, Mercuri, A, Sicari, R, Picano, E, Rodriguez Munoz, D, Lozano Granero, C, Carbonell San Roman, A, Moya Mur, JL, Fernandez-Golfin, C, Moreno Planas, J, Fernandez Santos, S, Casas Rojo, E, Hernandez-Madrid, A, Zamorano Gomez, JL, Reid, A B, Pearce, K, Gamlin, W, Miller, C, Schmitt, M, Park, JH, Seong, IW, Kim, KH, Kim, MJ, Jung, HO, Sohn, IS, Park, SM, Cho, GY, Choi, JO, Park, SW, study, NORMAL, Shetye, A, Nazir, SA, Khan, JN, Singh, A, Kanagala, P, Squire, I, Mccann, GP, Novo, G, Di Lisi, D, Meschisi, MC, Brunco, V, Badalamenti, G, Bronte, E, Russo, A, Novo, S, De Marchi, S F, Von Tscharner, M, Urheim, S, Aakhus, S, Seiler, C, Schmalholz, S, Cikes, M, Biering-Sorensen, T, Cheng, S, Oparil, S, Izzo, J, Pitt, B, Solomon, SD, Smarz, K, Zaborska, B, Jaxa-Chamiec, T, Tysarowski, M, Budaj, A, Illatopa, V, Cordova, F, Aguirre, O, Sanabria, S, Ortega, J, Peluso, D, Romeo, G, Perazzolo Marra, M, Tona, F, Famoso, G, Pigatto, E, Cozzi, F, Iliceto, S, Badano, LP, Wellnhofer, E, Kriatselis, C, Gerds-Li, JH, Kropf, M, Pieske, B, Graefe, M, De La Rosa Riestra, A, Martinez Santos, P, Batlle Lopez, E, Vilacosta, I, Sanchez Sauce, B, Espana Barrio, E, Jimenez Valtierra, J, Campuzano Ruiz, R, Alonso Bello, J, Martin Rios, MD, Sattarzadeh Badkoubeh, R, Farrashi, M, Abtahi, H, Sadeghi, H, Sadeghipour, P, Tavoosi, A, Mandour Ali, M, Abdel Rahman, TA, Mohamed, LA, Maghraby, HM, Kora, IM, Abdel Hameed, FR, Ali, MN, Azoz, A, Al Shehri, A, Youssef, A, Gad, A, Alsharqi, M, Alsaikhan, L, Pontone, G, Andreini, D, Rota, C, Guglielmo, M, Mushtaq, S, Baggiano, A, Beltrama, V, Solbiati, A, Guaricci, AI, Pepi, M, Krljanac, G, Trifunovic, D, Sobic Saranovic, D, Savic, L, Grozdic Milojevic, I, Asanin, M, Srdic, M, Petrovic, M, Zlaic, N, Mrdovic, I, Acar, R, Dogan, C, Izci, S, Gecmen, C, Unkun, T, Cap, M, Erdogan, E, Onal, C, Yilmaz, F, Ozdemir, N, Nucifora, G, Muser, D, Tioni, C, Zanuttini, D, Morocutti, G, Spedicato, L, Bernardi, G, Proclemer, A, Sirtautas, A, Pranevicius, R, Zapustas, N, Briedis, K, Valuckiene, Z, Jurkevicius, R, Roos, S T, Juffermans, LJM, Enait, V, Van Royen, N, Van Rossum, AC, Kamp, O, Qasem, M S, Khalaf, HASSEN, Hitham, SAKER, Osama, AS, Abazid, RAMI, Guall, RAHIM, Durdan, SHAFAT, Mohammed, ZYAD, Marini, C, Stella, S, Rosa, I, Ancona, F, Spartera, M, Italia, L, Latib, A, Colombo, A, Margonato, A, Agricola, E, Fabiani, I, Scatena, C, Mazzanti, C, Conte, L, Pugliese, N, Barletta, V, Bortolotti, U, Naccarato, AG, Di Bello, V, Gillis, K, Bala, G, Roosens, B, Hernot, S, Remory, I, Droogmans, S, Cosyns, B, Bandera, F, Generati, G, Labate, V, Donghi, V, Pellegrino, M, Carbone, F, Alfonzetti, E, Guazzi, M, Borowiec, A, Dabrowski, R, Kowalik, I, Firek, B, Chwyczko, T, Szwed, H, Lim, YJ, Kawamura, A, Kawano, S, Chalbia, T E, Zaroui, A, Ben Said, R, Ben Halima, M, Kheder, N, Farhati, A, Mourali, S, Mechmech, R, Santos, M, Leite, L, Martins, R, Baptista, R, Barbosa, A, Ribeiro, N, Oliveira, A, Castro, G, Pego, M, Gao, S A, Polte, C L, Lagerstrand, K, Johnsson, A A, Janulewicz, M, Bech-Hanssen, O, Zilberszac, R, Gabriel, H, Wisser, W, Maurer, G, Rosenhek, R, Farrag, AAM, El Aroussy, W, Abdel Ghany, M, Al Adeeb, K, Palmiero, G, Ascione, L, Carlomagno, G, Sordelli, C, Ferro, A, Ascione, R, Severino, S, Caso, P, Aruta, P, Muraru, D, Janei, C, Haertel Miglioranza, M, Cavalli, G, Romeo, G, Peluso, D, Cucchini, U, Iliceto, S, Badano, L, De Diego Soler, O, Armario Bel, X, Garcia-Garcia, C, Ferrer Sistach, E, Rueda Sobella, F, Oliveras Vila, T, Labata Salvador, C, Serra Flores, J, Lopez-Ayerbe, J, Bayes-Genis, A, Fasano, D, Conte, E, Gonella, A, Morena, L, Civelli, D, Losardo, L, Margaria, F, Riva, L, Tanga, M, Tamborini, G, Carminati, C, Muratori, M, Gripari, P, Ghulam Ali, S, Fusini, L, Vignati, C, Bartorelli, AL, Alamanni, F, Pepi, M, Ancona, F, Rosa, I, Stella, S, Marini, C, Spartera, M, Latib, A, Montorfano, M, Colombo, A, Margonato, A, Agricola, E, Raafat, D M, Ismaiel, A, Ali, N, Amry, S, Medicine, Faculty of, University, Assiut, Assiut, Egypt, Department, Pediatric, Marchel, M, Serafin, A, Kochanowski, J, Filipiak, KJ, Opolski, G, De Gregorio, C, Speranza, G, Ando', G, Magaudda, L, Gommans, D H F, Cramer, GE, Bakker, J, Michels, M, Dieker, HJ, Fouraux, MA, Marcelis, CLM, Timmermans, J, Brouwer, MA, Kofflard, MJM, Godinho, A R, Vasconcelos, M, Araujo, V, Almeida, P, Sousa, C, Macedo, F, Cardoso, JS, Maciel, MJ, Mielczarek, M, Voilliot, D, Huttin, O, Venner, C, Olivier, A, Villemin, T, Deballon, R, Manenti, V, Juilliere, Y, Selton-Suty, C, Bandera, F, Generati, G, Pellegrino, M, Labate, V, Carbone, F, Alfonzetti, E, Guazzi, M, Kubik, M, Dabrowska-Kugacka, A, Dorniak, K, Lewicka, E, Szalewska, D, Kutniewska-Kubik, M, Raczak, G, Cho, J Y, Kim, K H, Yoon, H J, Park, H J, Ahn, Y, Jeong, M H, Cho, J G, Park, J C, Kim, J H, Tarando, F, Galli, E, Habib, G, Schnell, F, Lederlin, M, Daubert, JC, Mabo, P, Donal, E, Lourenco Marmelo, B F, Faria, R, Magalhaes, P, Marques, N, Domingues, K, Lourenco, C, Almeida, AR, Teles, L, Picarra, B, Azevedo, O, SUNSHINE, Grupo, Reis, L, Lourenco, C, Oliveira, M, Magalhaes, P, Domingues, K, Marmelo, B, Almeida, A, Picarra, B, Faria, R, Marques, N, Sunshine, Domingues, K, Bento, D, Lourenco, C, Magalhaes, P, Cruz, I, Marmelo, B, Reis, L, Picarra, B, Faria, R, Azevedo, O, group, Sunshine, Krestjyaninov, MV, Gimaev, RH, Melnikova, MA, Olezov, NV, Ruzov, VI, Mesquita, J, Goncalves, P, Almeida, M S, Branco, P, Carvalho, M S, Dores, H, Gaspar, M A, Sousa, H, Andrade, M J, Mendes, M, Ikonomidis, I, Makavos, G, Varoudi, M, Papadavid, E, Andreadou, I, Gravanis, K, Liarakos, N, Pavlidis, G, Rigopoulos, D, Lekakis, J, Ferferieva, V, Deluyker, D, Bito, V, Peluso, D, Pigatto, E, Romeo, G, Muraru, D, Cozzi, F, Punzi, L, Iliceto, S, Badano, LP, Peluso, D, Pigatto, E, Romeo, G, Muraru, D, Cozzi, F, Iliceto, S, Badano, LP, King, GJ, Neilan, T, Coen, K, Gannon, S, Bennet, K, Clarke, JG, D'ascenzi, F, Solari, M, Cameli, M, Focardi, M, Corrado, D, Bonifazi, M, Henein, M, Mondillo, S, Ferrera Duran, C, Gomez-Escalonilla, C, De Agustin, A, Egido, J, Islas, F, Simal, P, Gomez De Diego, JJ, Luaces, M, Macaya, C, Perez De Isla, L, Sormani, P, Zancanella, M, Rusconi, C, Musca, F, Santambrogio, G, De Chiara, B, Vallerio, P, Cairoli, R, Giannattasio, G, Moreo, A, Gonzalez Fernandez, O, Alvarez Ortega, C, Mori Junco, R, Caro Codon, J, Meras Colunga, P, Ponz De Antonio, I, Lopez Fernandez, T, Valbuena Lopez, S, Moreno Yanguela, M, Lopez-Sendon, JL, Tereshina, O, Surkova, E, Cambronero Cortinas, E, Bonanad-Lozano, C, Lopez-Lereu, MP, Monmeneu-Menadas, JV, Gavara, J, De Dios, E, Paya-Chaume, A, Escribano-Alarcon, D, Chorro-Gasco, FJ, Bodi-Peris, V, Kupczynska, K, Michalski, BW, Miskowiec, D, Kasprzak, JD, Lipiec, P, Carvalho, J F, Morgado, G, Caldeira, D, Cruz, I, Joao, I, Almeida, A R, Lopes, L, Fazendas, P, Cotrim, C, Pereira, H, Shivalkar, B, De Block, C, Buys, D, Salgado, R, Vrints, C, Van Gaal, L, Aghamohammadzadeh, R, Mctear, C, Irwin, RB, Cifra, B, Dragulescu, A, Friedberg, M, Mertens, L, Cifra, B, Dragulescu, A, Friedberg, M, Mertens, L, Bandera, F, Carbone, F, Generati, G, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Kuznetsov, VA, Krinochkin, DV, Yaroslavskaya, EI, Zaharova, EH, Pushkarev, GS, Van Zalen, JJ, Sugihara, C, Patel, NR, Sulke, AN, Lloyd, GW, Kochanowski, J, Piatkowski, R, Scislo, P, Grabowski, M, Marchel, M, Opolski, G, Goebel, B, Roland, H, Hamadanchi, A, Otto, S, Jung, C, Lauten, A, Figulla, HC, Poerner, TC, Ladeiras-Lopes, R, Sampaio, F, Fonseca, P, Fontes-Carvalho, R, Pinho, M, Campos, AS, Castro, P, Fonseca, C, Ribeiro, J, Gama, V, Goebel, B, Heck, R, Hamdanchi, A, Otto, S, Jung, C, Lauten, A, Figulla, HR, Poerner, TC, Karvandi, M, Ranjbar, S, Ghaffaripour Jahromi, M, Karvandi, M, Ranjbar, S, Alonso Salinas, G, Hinojar, R, Fernandez Golfin, C, Esteban, A, Pascual-Izco, M, Garcia-Martin, A, Casas Rojo, E, Jimenez-Nacher, JJ, Zamorano, JL, Unkun, T, Gecmen, C, Cap, M, Izci, S, Erdogan, E, Onal, C, Acar, R, Bakal, RB, Kaymaz, C, Ozdemir, N, Ranjbar, S, Karvandi, M, Ghaffaripour Jahromi, M, Hubert, A, Galand, V, Schnell, F, Matelot, D, Martins, R, Leclercq, C, Carre, F, Enescu, OA, Suran, BC, Margulescu, AD, Rimbas, RC, Siliste, C, Vinereanu, D, Liccardo, M, Nocerino, P, Urso, AC, Borrino, A, Carbone, C, Follero, P, Ciardiello, C, Prato, L, Salzano, G, Cameli, M, Marino, F, Ruspetti, A, Sparla, S, Di Tommaso, C, Loiacono, F, Focardi, M, D'ascenzi, F, Henein, M, Mondillo, S, Ako, E, Porter, J, Walker, M, Lembo, M, Lo Iudice, F, Esposito, R, Santoro, C, Cocozza, S, Izzo, R, De Luca, N, De Simone, G, Trimarco, B, Galderisi, M, Goffredo, C, Gervasi, F, Patti, G, Mega, S, Bono, M, Di Sciascio, G, Enache, R, Buture, A, Badea, R, Platon, P, Ghiorghiu, I, Jurcut, R, Coman, IM, Popescu, BA, Ginghina, C, Novo, G, Lunetta, M, Spoto, MS, Lo Vi, AM, Pensabene, G, Meschisi, MC, Carita, P, Coppola, G, Novo, S, Assennato, P, Wdowiak-Okrojek, K, Shim, A, Wejner-Mik, P, Kasprzak, JD, Lipiec, P, Nemes, A, Havasi, K, Domsik, P, Kalapos, A, Forster, T, Nemes, A, Piros, GA, Domsik, P, Kalapos, A, Lengyel, C, Orosz, A, Forster, T, Di Salvo, G, Bulbul, Z, Issa, Z, Al Sehly, A, Pergola, V, Oufi, S, Capotosto, L, Conde, Y, Cimino, E, Rinaldi, E, Ashurov, R, Ricci, S, Pergolini, M, Vitarelli, A, Caravaca, P, Lujan Valencia, JE, Chaparro, M, Garcia-Guerrero, A, Cristo Ropero, MJ, Izquierdo Bajo, A, Madrona, L, Recio-Mayoral, A, Maceira Gonzalez, A M, Monmeneu, JV, Igual, B, Lopez Lereu, P, Garcia, MP, Iriart, X, Selmi, W, Jalal, Z, Thambo, JB, Jug, B, Kosuta, D, and Fras, Z
Abstract: Background: Handheld ultrasound devices allow for a bedside screening although quantitative parameters are not easily obtained. We aim to assess the reliability of visual qualitative evaluation of left ventricle (LV) compared with standard quantitative evaluation with 2D transthoracic echocardiography (TTE). Methods: Two cardiologists have reviewed 135 consecutive standard TTE examinations. Both observers visually assessed LV size, hypertrophy (LVH) and ejection fraction (EF). LV diameter, volume, wall thickness and EF (Teichholz and Simpson) were also measured by both observers. Visual and quantitative agreement and inter and intraobserver variability were calculated. Results: Image quality allowed for evaluation of 130 examinations. Visually assessed EF compared with Simpson had better consistency (Intraclass correlation coefficient [ICC] 0,91 IC95% 0,88-0,94) than with Teichholz (ICC 0,75 IC95% 0,66-0,82). We have also observed good interobserver agreement regarding visually assessed EF (ICC 0,81 IC95% 0,71-0,87) and Simpson EF (ICC 0,80 IC95% 0,70-0,89) as well as good intraobserver agreement (visual EF: ICC 0,81 IC95% 0,74-0,86; Simpson: ICC 0,89 IC95% 0,84-0,93). Regarding LVH we found moderate agreement between visual and quantitative assessment (weighted Kappa [wK] 0,44 (IC95% 0,32-0,56)), moderate interobserver agreement for quantitative assessment (ICC 0,59 IC95% 0,44-0,71) and poor interobserver agreement for visual assessment (wK 0,19 IC95% 0,08-0,30). Intraobserver variability regarding LVH visual estimation was moderate (wK 0,40 IC95% 0,29-0,52) and regarding LVH quantification was good (ICC 0,78 IC95% 0,70-0,84). LVH was visually overestimated in 25% of examinations. Regarding LV size, we found poor agreement between visual assessment and its quantification with end-diastolic diameter (wK 0,22 IC95% 0,06-0,39) and moderate agreement between visual assessment and end-systolic LV volume (wK 0,62 IC95% 0,47-0,77). Interobserver agreement regarding quantitative volume assessment was good (ICC 0,90 IC95% 0,85-0,94) and regarding visual assessment was moderate (wK 0,43 IC95% 0,26-0,70). We found good intraobserver variability of volume measurement (wK 0,64 IC95% 0,50-0,78) and of visual size assessment (ICC 0,96 IC95% 0,94-0,97). Conclusions: Visual LVEF assessment is consistent with quantitative assessment and should be regarded as a reliable parameter that can be obtained from bedside examination with a handheld device. Visual assessment of LV size and wall thickness is less reliable than its quantification and should be confirmed with standard measurements.
Published: 2015
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47. MODERATED POSTER SESSION: Imaging in interventional cardiology: Wednesday 3 December 2014, 09:00-16:00 * Location: Moderated Poster area

Author: Wang, YS, Gong, X, Su, YG, Cui, J, Shu, XH, Perge, P, Kovacs, A, Liptai, C, Apor, A, Nagy, KV, Geller, L, Szeplaki, G, Merkely, B, Goebel, B, Hamadanchi, A, Schmidt-Winter, C, Otto, S, Jung, C, Figulla, HR, Poerner, TC, Rotzak, R, Aharonovich, A, Geva, Y, Rozenman, Y, Capotosto, L, D'angeli, I, Azzano, A, Placanica, A, Mukred, K, Rinaldi, E, Ashurov, R, Tanzilli, G, Mangieri, E, Vitarelli, A, Lesevic, H, Karl, M, Rosner, S, Ott, I, Sonne, C, Borges, I P, Peixoto, ECS, Peixoto, RTS, Peixoto, RTS, Marcolla, VF, Citro, R, Baldi, C, Provenza, G, Di Maio, M, Silverio, A, Prota, C, Di Muro, M R, Bossone, E, Giudice, P, Piscione, F, Muratori, M, Fusini, L, Gripari, P, Tamborini, G, Ghulam Ali, S, Salvi, L, Bartorelli, AL, Agrifoglio, M, Alamanni, F, Pepi, M, Fusini, L, Tamborini, G, Muratori, M, Cefalu', C, Bottari, VE, Gripari, P, Ghulam Ali, S, Andreini, D, Pontone, G, and Pepi, M
Abstract: Objective: To assess left ventricular (LV) twist by three-dimensional speckle tracking imaging (3D-STI) in a pacing induced heart failure canine model with left bundle-branch block (LBBB) undergoing cardiac resynchronization therapy (CRT). Methods: After induction of left bundle branch block by radiofrequency ablation, rapid right ventricular pacing (RVP) at 200 beats/min was utilized in 22 adult beagle dogs for 6 weeks to induce heart failure. Then 15 dogs received CRT for 4 weeks and others were treated as control. Apical full-volume acquisition of the LV was obtained in conscious animals at baseline, the end of 6-week RVP and the end of 4-week CRT. Peak LV systolic twist (Ptw) and torsion (Ptor) along with peak apical and basal rotation were automatically calculated by Tom-Tec 4D LV Analysis 3.0 software to identify the ideal parameter in predicting treatment response of CRT. Results: After 4 weeks of CRT, LVEF increased [(31.97 ± 1.47) vs. (37.47 ± 3.60)%, p=0.002] and LVESV decreased [(24.13 ± 3.72) vs. (21.87 ± 3.15)ml, p=0.007] significantly in dogs with heart failure. By shortening the delay of basal rotation [(23.73 ± 9.98) vs. (17.87 ± 5.94)ms, p=0.009], CRT improved peak LV systolic twist [(6.88 ± 0.99) vs. (8.03 ± 0.63)°, p=0.008] and torsion [(1.21 ± 0.36) vs. (1.98 ± 0.39)°/cm, p=0.010] instead of peak apical [(5.97 ± 0.57) vs. (6.13 ± 0.61)°, p=0.103] and basal rotation [(2.08 ± 0.45) vs. (2.13 ± 0.46)°, p=0.469]. CRT treatment response, defined as improvement of LVESV≥15%, was observed in 9 dogs. Significant difference was found in Ptw [(7.43 ± 0.61) vs. (6.06 ± 0.89)°, p=0.016] and Ptor [(1.43 ± 0.45) vs. (0.67 ± 0.36)°/cm, p=0.042] between responders and nonresponders. The cut-off values derived from receiver-operating characteristic curve analysis were 6.73° for Ptw and 1.00°/cm for Ptor with satisfying sensitivity as 89% and 85%, specificity as 83% and 84%, respectively. Conclusions: CRT improved LV systolic twist and reversed LV remodeling by reconciling basal with apical rotation. Peak twist and torsion evaluated by 3D-STI demonstrated potential prediction value for treatment response of CRT.
Published: 2014
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48. Poster session Thursday 12 December - AM: 12/12/2013, 08:30-12:30 * Location: Poster area

Author: Abdovic, E, Abdovic, S, Hristova, K, Hristova, K, Katova, TZ, Katova, TZ, Gocheva, N, Gocheva, N, Pavlova, M, Pavlova, M, Gurzun, M M, Ionescu, A, Canpolat, U, Yorgun, H, Sunman, H, Sahiner, L, Kaya, EB, Ozer, N, Tokgozoglu, L, Kabakci, G, Aytemir, K, Oto, A, Gonella, A, Dascenzo, F, Casasso, F, Conte, E, Margaria, F, Grosso Marra, W, Frea, S, Morello, M, Bobbio, M, Gaita, F, Seo, HY, Lee, SP, Lee, JM, Yoon, YE, Park, E, Kim, HK, Park, SJ, Lee, H, Kim, YJ, Sohn, DW, Nemes, A, Domsik, P, Kalapos, A, Orosz, A, Lengyel, C, Forster, T, Enache, R, Muraru, D, Popescu, BA, Calin, A, Nastase, O, Botezatu, D, Purcarea, F, Rosca, M, Beladan, CC, Ginghina, C, Canpolat, U, Aytemir, K, Ozer, N, Yorgun, H, Sahiner, L, Kaya, EB, Oto, A, Trial, Turkish Atrial Fibrosis, Muraru, D, Piasentini, E, Mihaila, S, Padayattil Jose, S, Peluso, D, Ucci, L, Naso, P, Puma, L, Iliceto, S, Badano, LP, Cikes, M, Jakus, N, Sutherland, GR, Haemers, P, Dhooge, J, Claus, P, Yurdakul, S, Oner, FATMA, Direskeneli, HANER, Sahin, TAYLAN, Cengiz, BETUL, Ercan, G, Bozkurt, AYSEN, Aytekin, SAIDE, Osa Saez, A M, Rodriguez-Serrano, M, Lopez-Vilella, R, Buendia-Fuentes, F, Domingo-Valero, D, Quesada-Carmona, A, Miro-Palau, VE, Arnau-Vives, MA, Palencia-Perez, M, Rueda-Soriano, J, Lipczynska, M, Piotr Szymanski, PS, Anna Klisiewicz, AK, Lukasz Mazurkiewicz, LM, Piotr Hoffman, PH, Kim, KH, Cho, SK, Ahn, Y, Jeong, MH, Cho, JG, Park, JC, Chinali, M, Franceschini, A, Matteucci, MC, Doyon, A, Esposito, C, Del Pasqua, A, Rinelli, G, Schaefer, F, group, the 4C study, Kowalik, E, Klisiewicz, A, Rybicka, J, Szymanski, P, Biernacka, EK, Hoffman, P, Lee, S, Kim, W, Yun, H, Jung, L, Kim, E, Ko, J, Ruddox, V, Norum, IB, Edvardsen, T, Baekkevar, M, Otterstad, JE, Erdei, T, Edwards, J, Braim, D, Yousef, Z, Fraser, AG, Cardiff, Investigators, MEDIA, Melcher, A, Reiner, B, Hansen, A, Strandberg, LE, Caidahl, K, Wellnhofer, E, Kriatselis, C, Gerd-Li, H, Furundzija, V, Thnabalasingam, U, Fleck, E, Graefe, M, Park, YJ, Moon, JG, Ahn, TH, Baydar, O, Kadriye Kilickesmez, KK, Ugur Coskun, UC, Polat Canbolat, PC, Veysel Oktay, VO, Umit Yasar Sinan, US, Okay Abaci, OA, Cuneyt Kocas, CK, Sinan Uner, SU, Serdar Kucukoglu, SK, Ferferieva, V, Claus, P, Rademakers, F, Dhooge, J, Le, T T, Wong, P, Tee, N, Huang, F, Tan, RS, Altman, M, Logeart, D, Bergerot, C, Gellen, B, Pare, C, Gerard, S, Sirol, M, Vicaut, E, Mercadier, JJ, Derumeaux, G A, investigators, PREGICA, Park, T-H, Park, J-I, Shin, S-W, Yun, S-H, Lee, J-E, Makavos, G, Kouris, N, Keramida, K, Dagre, A, Ntarladimas, I, Kostopoulos, V, Damaskos, D, Olympios, CD, Leong, DP, Piers, SRD, Hoogslag, GE, Hoke, U, Thijssen, J, Ajmone Marsan, N, Schalij, MJ, Bax, JJ, Zeppenfeld, K, Delgado, V, Rio, P, Branco, L, Galrinho, A, Cacela, D, Abreu, J, Timoteo, A, Teixeira, P, Pereira-Da-Silva, T, Selas, M, Cruz Ferreira, R, Popa, B A, Zamfir, L, Novelli, E, Lanzillo, G, Karazanishvili, L, Musica, G, Stelian, E, Benea, D, Diena, M, Cerin, G, Fusini, L, Mirea, O, Tamborini, G, Muratori, M, Gripari, P, Ghulam Ali, S, Cefalu, C, Maffessanti, F, Andreini, D, Pepi, M, Mamdoo, F, Goncalves, A, Peters, F, Matioda, H, Govender, S, Dos Santos, C, Essop, MR, Kuznetsov, V A, Yaroslavskaya, E I, Pushkarev, G S, Krinochkin, D V, Kolunin, G V, Bennadji, A, Hascoet, S, Dulac, Y, Hadeed, K, Peyre, M, Ricco, L, Clement, L, Acar, P, Ding, WH, Zhao, Y, Lindqvist, P, Nilson, J, Winter, R, Holmgren, A, Ruck, A, Henein, MY, Illatopa, V, Cordova, F, Espinoza, D, Ortega, J, Cavalcante, JL, Patel, MT, Katz, W, Schindler, J, Crock, F, Khanna, MK, Khandhar, S, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Tokuda, H, Kawamura, A, Maekawa, Y, Hayashida, K, Fukuda, K, Le Tourneau, T, Kyndt, F, Lecointe, S, Duval, D, Rimbert, A, Merot, J, Trochu, JN, Probst, V, Le Marec, H, Schott, JJ, Veronesi, F, Addetia, K, Corsi, C, Lamberti, C, Lang, RM, Mor-Avi, V, Gjerdalen, G F, Hisdal, J, Solberg, EE, Andersen, TE, Radunovic, Z, Steine, K, Maffessanti, F, Gripari, P, Tamborini, G, Muratori, M, Fusini, L, Ferrari, C, Caiani, EG, Alamanni, F, Bartorelli, AL, Pepi, M, Dascenzi, F, Cameli, M, Iadanza, A, Lisi, M, Reccia, R, Curci, V, Sinicropi, G, Henein, M, Pierli, C, Mondillo, S, Rekhraj, S, Hoole, SP, Mcnab, DC, Densem, CG, Boyd, J, Parker, K, Shapiro, LM, Rana, BS, Kotrc, M, Vandendriessche, T, Bartunek, J, Claeys, MJ, Vanderheyden, M, Paelinck, B, De Bock, D, De Maeyer, C, Vrints, C, Penicka, M, Silveira, C, Albuquerque, ESA, Lamprea, DL, Larangeiras, VL, Moreira, CRPM, Victor Filho, MVF, Alencar, BMA, Silveira, AQMS, Castillo, JMDC, Zambon, E, Iorio, A, Carriere, C, Pantano, A, Barbati, G, Bobbo, M, Abate, E, Pinamonti, B, Di Lenarda, A, Sinagra, G, Salemi, V M C, Tavares, L, Ferreira Filho, JCA, Oliveira, AM, Pessoa, FG, Ramires, F, Fernandes, F, Mady, C, Cavarretta, E, Lotrionte, M, Abbate, A, Mezzaroma, E, De Marco, E, Peruzzi, M, Loperfido, F, Biondi-Zoccai, G, Frati, G, Palazzoni, G, Park, T-H, Lee, J-E, Lee, D-H, Park, J-S, Park, K, Kim, M-H, Kim, Y-D, Van T Sant, J, Gathier, WA, Leenders, GE, Meine, M, Doevendans, PA, Cramer, MJ, Poyhonen, P, Kivisto, S, Holmstrom, M, Hanninen, H, Schnell, F, Betancur, J, Daudin, M, Simon, A, Carre, F, Tavard, F, Hernandez, A, Garreau, M, Donal, E, Calore, C, Muraru, D, Badano, LP, Melacini, P, Mihaila, S, Denas, G, Naso, P, Casablanca, S, Santi, F, Iliceto, S, Aggeli, C, Venieri, E, Felekos, I, Anastasakis, A, Ritsatos, K, Kakiouzi, V, Kastellanos, S, Cutajar, I, Stefanadis, C, Palecek, T, Honzikova, J, Poupetova, H, Vlaskova, H, Kuchynka, P, Linhart, A, Elmasry, O, Mohamed, MH, Elguindy, WM, Bishara, PNI, Garcia-Gonzalez, P, Cozar-Santiago, P, Bochard-Villanueva, B, Fabregat-Andres, O, Cubillos-Arango, A, Valle-Munoz, A, Ferrer-Rebolleda, J, Paya-Serrano, R, Estornell-Erill, J, Ridocci-Soriano, F, Jensen, M, Havndrup, O, Christiansen, M, Andersen, PS, Axelsson, A, Kober, L, Bundgaard, H, Karapinar, H, Kaya, A, Uysal, EB, Guven, AS, Kucukdurmaz, Z, Oflaz, MB, Deveci, K, Sancakdar, E, Gul, I, Yilmaz, A, Tigen, M K, Karaahmet, T, Dundar, C, Yalcinsoy, M, Tasar, O, Bulut, M, Takir, M, Akkaya, E, Jedrzejewska, I, Braksator, W, Krol, W, Swiatowiec, A, Dluzniewski, M, Lipari, P, Bonapace, S, Zenari, L, Valbusa, F, Rossi, A, Lanzoni, L, Molon, G, Canali, G, Campopiano, E, Barbieri, E, Rueda Calle, E, Alfaro Rubio, F, Gomez Gonzalez, J, Gonzalez Santos, P, Cameli, M, Lisi, M, Focardi, M, Dascenzi, F, Solari, M, Galderisi, M, Mondillo, S, Pratali, L, Bruno, R M, Corciu, AI, Comassi, M, Passera, M, Gastaldelli, A, Mrakic-Sposta, S, Vezzoli, A, Picano, E, Perry, R, Penhall, A, De Pasquale, C, Selvanayagam, J, Joseph, M, Simova, I I, Katova, T M, Kostova, V, Hristova, K, Lalov, I, Dascenzi, F, Pelliccia, A, Natali, BM, Cameli, M, Alvino, F, Zorzi, A, Corrado, D, Bonifazi, M, Mondillo, S, Rees, E, Rakebrandt, F, Rees, DA, Halcox, JP, Fraser, AG, Odriscoll, J, Lau, N, Perez-Lopez, M, Sharma, R, Lichodziejewska, B, Goliszek, S, Kurnicka, K, Kostrubiec, M, Dzikowska Diduch, O, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Gheorghe, LL, Castillo Ortiz, J, Del Pozo Contreras, R, Calle Perez, G, Sancho Jaldon, M, Cabeza Lainez, P, Vazquez Garcia, R, Fernandez Garcia, P, Chueca Gonzalez, E, Arana Granados, R, Zhao, XX, Xu, XD, Bai, Y, Qin, YW, Leren, IS, Hasselberg, NE, Saberniak, J, Leren, TP, Edvardsen, T, Haugaa, KH, Daraban, A M, Sutherland, GR, Claus, P, Werner, B, Gewillig, M, Voigt, JU, Santoro, A, Ierano, P, De Stefano, F, Esposito, R, De Palma, D, Ippolito, R, Tufano, A, Galderisi, M, Costa, R, Fischer, C, Rodrigues, A, Monaco, C, Lira Filho, E, Vieira, M, Cordovil, A, Oliveira, E, Mohry, S, Gaudron, P, Niemann, M, Herrmann, S, Strotmann, J, Beer, M, Hu, K, Bijnens, B, Ertl, G, Weidemann, F, Baktir, AO, Sarli, B, Cicek, M, Karakas, MS, Saglam, H, Arinc, H, Akil, MA, Kaya, H, Ertas, F, Bilik, MZ, Yildiz, A, Oylumlu, M, Acet, H, Aydin, M, Yuksel, M, Alan, S, Odriscoll, J, Gravina, A, Di Fino, S, Thompson, M, Karthigelasingham, A, Ray, K, Sharma, R, De Chiara, B, Russo, CF, Alloni, M, Belli, O, Spano, F, Botta, L, Palmieri, B, Martinelli, L, Giannattasio, C, Moreo, A, Mateescu, AD, La Carrubba, S, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Ginghina, C, Popescu, BA, Nicolosi, GL, Antonini-Canterin, F, Malev, E, Omelchenko, M, Vasina, L, Luneva, E, Zemtsovsky, E, Cikes, M, Velagic, V, Gasparovic, H, Kopjar, T, Colak, Z, Hlupic, LJ, Biocina, B, Milicic, D, Tomaszewski, A, Kutarski, A, Poterala, M, Tomaszewski, M, Brzozowski, W, Kijima, Y, Akagi, T, Nakagawa, K, Ikeda, M, Watanabe, N, Ueoka, A, Takaya, Y, Oe, H, Toh, N, Ito, H, Bochard Villanueva, B, Paya-Serrano, R, Fabregat-Andres, O, Garcia-Gonzalez, P, Perez-Bosca, JL, Cubillos-Arango, A, Chacon-Hernandez, N, Higueras-Ortega, L, De La Espriella-Juan, R, Ridocci-Soriano, F, Noack, T, Mukherjee, C, Ionasec, RI, Voigt, I, Kiefer, P, Hoebartner, M, Misfeld, M, Mohr, F-W, Seeburger, J, Daraban, A M, Baltussen, L, Amzulescu, MS, Bogaert, J, Jassens, S, Voigt, JU, Duchateau, N, Giraldeau, G, Gabrielli, L, Penela, D, Evertz, R, Mont, L, Brugada, J, Berruezo, A, Bijnens, BH, Sitges, M, Yoshikawa, H, Suzuki, M, Hashimoto, G, Kusunose, Y, Otsuka, T, Nakamura, M, Sugi, K, Ruiz Ortiz, M, Mesa, D, Romo, E, Delgado, M, Seoane, T, Martin, M, Carrasco, F, Lopez Granados, A, Arizon, JM, Suarez De Lezo, J, Magalhaes, A, Cortez-Dias, N, Silva, D, Menezes, M, Saraiva, M, Santos, L, Costa, A, Costa, L, Nunes Diogo, A, Fiuza, M, Ren, B, De Groot-De Laat, LE, Mcghie, J, Vletter, WB, Geleijnse, ML, Toda, H, Oe, H, Osawa, K, Miyoshi, T, Ugawa, S, Toh, N, Nakamura, K, Kohno, K, Morita, H, Ito, H, El Ghannudi, S, Germain, P, Samet, H, Jeung, M, Roy, C, Gangi, A, Orii, M, Hirata, K, Yamano, T, Tanimoto, T, Ino, Y, Yamaguchi, T, Kubo, T, Imanishi, T, Akasaka, T, Sunbul, M, Kivrak, T, Oguz, M, Ozguven, S, Gungor, S, Dede, F, Turoglu, HT, Yildizeli, B, Mutlu, B, Mihaila, S, Muraru, D, Piasentini, E, Peluso, D, Cucchini, U, Casablanca, S, Naso, P, Iliceto, S, Vinereanu, D, Badano, LP, Rodriguez Munoz, DA, Moya Mur, JL, Becker Filho, D, Gonzalez, A, Casas Rojo, E, Garcia Martin, A, Recio Vazquez, M, Rincon, LM, Fernandez Golfin, C, Zamorano Gomez, JL, Ledakowicz-Polak, A, Polak, L, Zielinska, M, Kamiyama, T, Nakade, T, Nakamura, Y, Ando, T, Kirimura, M, Inoue, Y, Sasaki, O, Nishioka, T, Farouk, H, Sakr, B, Elchilali, K, Said, K, Sorour, K, Salah, H, Mahmoud, G, Casanova Rodriguez, C, Cano Carrizal, R, Iglesias Del Valle, D, Martin Penato Molina, A, Garcia Garcia, A, Prieto Moriche, E, Alvarez Rubio, J, De Juan Bagua, J, Tejero Romero, C, Plaza Perez, I, Korlou, P, Stefanidis, A, Mpikakis, N, Ikonomidis, I, Anastasiadis, S, Komninos, K, Nikoloudi, P, Margos, P, and Pentzeridis, P
Abstract: Purpose: Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. It is a disease of the elderly and it is common in patients (pts) with structural heart disease. Hypertension (HA), hypertensive heart disease (HHD), diabetes mellitus (DM), coronary artery disease (CAD), heart failure (HF), and valvular heart disease (VHD) are recognized predisposing factors to AF. Objectives: To echocardiographicly disclose the most common predisposing morbidities to AF in our population sample. Methods: From June 2000 to February 2013, 3755 consecutive pts with AF were studied during echocardiographic check-up. According to transthoracic echo, pts were divided in groups based on dominative underlying heart diseases. Electrocardiographically documented AF was subdivided in two groups: transitory and chronic. Transitory AF fulfilled criteria for paroxysmal or persistent AF. Chronic AF were cases of long-standing persistent or permanent AF. Results: The median age was 72 years, age range between 16 and 96 years. There were 51.4% of females. Chronic AF was observed in 68.3% pts. Distribution of underlying heart diseases is shown in figure. Lone AF was diagnosed in only 25 pts, mostly in younger males (median age 48 years, range 29–59, men 80%). Chronic AF was predominant in groups with advanced cardiac remodeling such as dilatative cardiomyopaty (DCM) and VHD, mostly in elderly. HA and DM were found in 75.4% and 18.8%, respectively. Almost 1/2 of pts with AF had HF and 59.2% had diastolic HF. Conclusion: Up to now, echocardiographic categorization of the predisposing factors to AF was not reported. Echocardiographic evaluation of patients with AF could facilitate in identification and well-timed treatment of predisposing comorbidites. Figure Etiological distribution of AF
Published: 2013
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49. Poster session Wednesday 11 December all day display: 11/12/2013, 09:30-16:00 * Location: Poster area

Author: Bertrand, PB, Grieten, L, Smeets, C, Verbrugge, FH, Mullens, W, Vrolix, M, Rivero-Ayerza, M, Verhaert, D, Vandervoort, P, Tong, L, Ramalli, A, Tortoli, P, Dhoge, J, Bajraktari, G, Lindqvist, P, Henein, MY, Obremska, M, Boratynska, MB, Kurcz, JK, Zysko, DZ, Baran, TB, Klinger, MK, Darahim, K, Mueller, H, Carballo, D, Popova, N, Vallee, J-P, Floria, M, Chistol, R, Tinica, G, Grecu, M, Rodriguez Serrano, M, Osa-Saez, A, Rueda-Soriano, J, Buendia-Fuentes, F, Domingo-Valero, D, Igual-Munoz, B, Alonso-Fernandez, P, Quesada-Carmona, A, Miro-Palau, V, Palencia-Perez, M, Bech-Hanssen, O, Polte, CL, Lagerstrand, K, Janulewicz, M, Gao, S, Erdogan, E, Akkaya, M, Bacaksiz, A, Tasal, A, Sonmez, O, Turfan, M, Kul, S, Vatankulu, MA, Uyarel, H, Goktekin, O, Mincu, RI, Magda, LS, Mihaila, S, Florescu, M, Mihalcea, D, Enescu, OE, Chiru, A, Popescu, B, Tiu, C, Vinereanu, D, 112/2011, Research grant, Broch, K, Kunszt, G, Massey, R, De Marchi, SF, Aakhus, S, Gullestad, L, Urheim, S, Yuan, L, Feng, JL, Jin, XY, Bombardini, T, Casartelli, M, Simon, D, Gaspari, MG, Procaccio, F, Hasselberg, NE, Haugaa, KH, Brunet, A, Kongsgaard, E, Donal, E, Edvardsen, T, Sahin, TAYLAN, Yurdakul, S, Cengiz, BETUL, Bozkurt, AYSEN, Aytekin, SAIDE, Cesana, F, Spano, F, Santambrogio, G, Alloni, M, Vallerio, P, Salvetti, M, Carerj, S, Gaibazzi, N, Rigo, F, Moreo, A, Group, APRES Collaborative, Wdowiak-Okrojek, K, Michalski, B, Kasprzak, JD, Shim, A, Lipiec, P, Generati, G, Pellegrino, M, Bandera, F, Donghi, V, Alfonzetti, E, Guazzi, M, Marcun, R, Stankovic, I, Farkas, J, Vlahovic-Stipac, A, Putnikovic, B, Kadivec, S, Kosnik, M, Neskovic, AN, Lainscak, M, Iliuta, L, Szymanski, P, Lipczynska, M, Klisiewicz, A, Sobieszczanska-Malek, M, Zielinski, T, Hoffman, P, Gjerdalen, G F, Hisdal, J, Solberg, EE, Andersen, TE, Radunovic, Z, Steine, K, Svanadze, A, Poteshkina, N, Krylova, N, Mogutova, P, Shim, A, Kasprzak, JD, Szymczyk, E, Wdowiak-Okrojek, K, Michalski, B, Stefanczyk, L, Lipiec, P, Benedek, T, Matei, C, Jako, B, Suciu, ZS, Benedek, I, Yaroshchuk, N A, Kochmasheva, V V, Dityatev, V P, Kerbikov, O B, Przewlocka-Kosmala, M, Orda, A, Karolko, B, Mysiak, A, Kosmala, W, Rechcinski, T, Wierzbowska-Drabik, K, Lipiec, P, Chmiela, M, Kasprzak, JD, Aziz, A, Hooper, J, Rayasamudra, S, Uppal, H, Asghar, O, Potluri, R, Zaroui, A, Mourali, MS, Rezine, Z, Mbarki, S, Jemaa, M, Aloui, H, Mechmeche, R, Farhati, A, Gripari, P, Maffessanti, F, Tamborini, G, Muratori, M, Fusini, L, Vignati, C, Bartorelli, AL, Alamanni, F, Agostoni, PG, Pepi, M, Ruiz Ortiz, M, Mesa, D, Delgado, M, Seoane, T, Carrasco, F, Martin, M, Mazuelos, F, Suarez De Lezo Herreros De Tejada, J, Romero, M, Suarez De Lezo, J, Brili, S, Stamatopoulos, I, Misailidou, M, Chrisochoou, C, Christoforatou, E, Stefanadis, C, Ruiz Ortiz, M, Mesa, D, Delgado, M, Martin, M, Seoane, T, Carrasco, F, Ojeda, S, Segura, J, Pan, M, Suarez De Lezo, J, Cammalleri, V, Ussia, GP, Muscoli, S, Marchei, M, Sergi, D, Mazzotta, E, Romeo, F, Igual Munoz, B, Bel 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Abstract: Purpose: With the advent of percutaneous transcatheter device closures in congenital heart defects and the emergence of percutaneous left atrial appendage closure, there is an increasingly important role for echocardiographic guidance and control of device position and function. Disc occluder devices frequently present as an unexplained ‘figure-of-8’ on echocardiography. The aim of this study was to clarify this ‘figure-of-8’ display and to relate its morphology to transducer position and device type. Methods: A mathematical model was developed to resemble disc occluder geometry and to allow a numerical simulation of the echocardiographic appearance. In addition, we developed an in vitro set-up for echocardiographic analysis of various disc occluders and various transducer positions. Results: In the mathematical model of an epitrochoid curve (closely resembling disc occluder geometry) a ‘figure-of-8’ display is obtained when emphasizing points with tangent vector perpendicular to the direction of ultrasound waves. Decreasing imaging depth results in a more asymmetric ‘figure-of-8’, with small upper part and wide lower part. Clinical and in vitro data are in close agreement with these results (Figure 1). Furthermore a ‘figure-of-8’ display is only obtained in a coronal imaging position, and is similar for different commercially available disc occluder types. Conclusions: The ‘figure-of-8’ display in the ultrasound image of a disc occluder is an imaging artifact due to the specific ‘epitrochoidal’ geometry of a deployed device and its interaction with ultrasound waves. The morphology of the ‘figure-of-8’ depends on transducer position, i.e. imaging depth, and is similar for different device types. Figure 1 Impact of imaging depth
Published: 2013
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50. Impact of Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography on Heart Team Treatment Decision-Making in Patients With Multivessel Coronary Artery Disease: Insights From the SYNTAX III REVOLUTION Trial

Author: Francesco Maisano, Marc Schönweiß, Ingrid Leal, Yosuke Miyazaki, Stefano De Martini, Marco Guglielmo, André Plass, Danny Schoors, Antonio L. Bartorelli, Thierry Folliguet, Daniele Andreini, Cristina Ferrari, Wietze Lindeboom, Saima Mushtaq, K Tanaka, G. Färber, Yuki Katagiri, Maurizio Roberto, Patrick W. Serruys, Rodrigo Modolo, Philipp A. Kaufmann, Yoshinobu Onuma, Jens Czapla, Xavier Orry, Laura Cavallotti, Paolo Olivares, Carlos Collet, Jeroen Sonck, Ioannis Diamantis, Pierre-Adrien Metzdorf, Giorgia Bonalumi, Radiology, Medical Imaging, Clinical sciences, Cardiology, Graduate School, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, ACS - Heart failure & arrhythmias, Andreini, D, Modolo, R, Katagiri, Y, Mushtaq, S, Sonck, J, Collet, C, De Martini, S, Roberto, M, Tanaka, K, Miyazaki, Y, Czapla, J, Schoors, D, Plass, A, Maisano, F, Kaufmann, P, Orry, X, Metzdorf, Pa, Folliguet, T, Farber, G, Diamantis, I, Schonweiss, M, Bonalumi, G, Guglielmo, M, Ferrari, C, Olivares, P, Cavallotti, L, Leal, I, Lindeboom, W, Onuma, Y, Serruys, Pw, Bartorelli, Al, and Investigators, Sir
Subjects: medicine.medical_specialty, Computed Tomography Angiography, medicine.medical_treatment, Clinical Decision-Making, Fractional flow reserve, 030204 cardiovascular system & hematology, Coronary Angiography, Severity of Illness Index, Decision Support Techniques, 030218 nuclear medicine & medical imaging, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, Heart team, Humans, Medicine, In patient, angiography, Coronary Artery Bypass, Patient Care Team, Syntax (programming languages), medicine.diagnostic_test, business.industry, Patient Selection, percutaneous coronary intervention, Coronary Stenosis, Coronary computed tomography angiography, Percutaneous coronary intervention, Prognosis, medicine.disease, Europe, Fractional Flow Reserve, Myocardial, Angiography, Cardiology, coronary computed tomography angiography, business, Cardiology and Cardiovascular Medicine, coronary artery disease, Decision-making
Abstract: Background: Fractional flow reserve (FFR) is a reliable tool for the functional assessment of coronary stenoses. FFR computed tomography (CT) derived (FFR CT ) has shown to be accurate, but its clinical usefulness in patients with complex coronary artery disease remains to be investigated. The present study sought to determine the impact of FFR CT on heart team’s treatment decision-making and selection of vessels for revascularization in patients with 3-vessel coronary artery disease. Methods: The trial was an international, multicenter study randomizing 2 heart teams to make a treatment decision between percutaneous coronary interventions and coronary artery bypass grafting using either coronary computed tomography angiography or conventional angiography. The heart teams received the FFR CT and had to make a treatment decision and planning integrating the functional component of the stenoses. Each heart team calculated the anatomic SYNTAX score, the noninvasive functional SYNTAX score and subsequently integrated the clinical information to compute the SYNTAX score III providing a treatment recommendation, that is, coronary artery bypass grafting, percutaneous coronary intervention, or equipoise coronary artery bypass grafting-percutaneous coronary intervention. The primary objective was to determine the proportion of patients in whom FFR CT changed the treatment decision and planning. Results: Overall, 223 patients were included. Coronary computed tomography angiography assessment was feasible in 99% of the patients and FFR CT analysis in 88%. FFR CT was available for 1030 lesions (mean FFR CT value 0.64±13). A treatment recommendation of coronary artery bypass grafting was made in 24% of the patients with coronary computed tomography angiography with FFR CT . The addition of FFR CT changed the treatment decision in 7% of the patients and modified selection of vessels for revascularization in 12%. With conventional angiography as reference, FFR CT assessment resulted in reclassification of 14% of patients from intermediate and high to low SYNTAX score tertile. Conclusions: In patients with 3-vessel coronary artery disease, a noninvasive physiology assessment using FFR CT changed heart team’s treatment decision-making and procedural planning in one-fifth of the patients. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02813473.
Published: 2019
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