Search

Your search keyword '"Bartsch, Yannic C."' showing total 143 results
Start Over Author "Bartsch, Yannic C."
143 results on '"Bartsch, Yannic C."'

2. Standardised quantitative assays for anti-SARS-CoV-2 immune response used in vaccine clinical trials by the CEPI Centralized Laboratory Network: a qualification analysis

Author

Zala, Vijay, De Almeida, Ana Paula, Fassoulas, Helen, Agrawal, Tanvi, Singh, Janmejay, Roy, Anjan Kumar, Berndsen, Saskia, de Mooij, Marina, Buitendijk, Hester, Stalpers, Coen, Jarju, Modou, Battistella, Filippo, Jeeninga, Rienk, Duijsings, Danny, Razzano, Ilaria, Molesti, Eleonora, Mazzini, Livia, Boccuto, Adele, Holder, Angela, Mee, Edward, Hurley, Matthew, Padley, Jennifer, Rose, Nicola, Gorman, Trina, Vila-Belda, Jose, James, Hannah, Carless, Jerome, Manak, Mark, Gagnon, Luc, Phay-Tran, Steven, Levesque-Damphousse, Philipa, Fabie, Aymeric, Daugan, Matthieu, Khan, Sarwat Tahsin, Proud, Pamela, Hussey, Bethan, Knott, Daniel, Charlton, Sue, Hallis, Bassam, Medigeshi, Guruprasad R, Garg, Neha, Anantharaj, Anbalagan, Raqib, Rubhana, Sarker, Protim, Alam, Mohammad Mamun, Rahman, Mustafizur, Murreddu, Marta, Balgobind, Angela, Hofman, Rick, Grappi, Silvia, Coluccio, Rosa, Calandro, Pierpaolo, Montomoli, Emanuele, Mattiuzzo, Giada, Prior, Sandra, Le Duff, Yann, Page, Mark, Mitchell, Jane, Schwartz, Lauren M, Bartsch, Yannic C, Azizi, Ali, and Bernasconi, Valentina

Published
2024
Full Text
View/download PDF

5. Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

Author

Yonker, Lael M., Swank, Zoe, Bartsch, Yannic C., Burns, Madeleine D., Kane, Abigail, Boribong, Brittany P., Davis, Jameson P., Loiselle, Maggie, Novak, Tanya, Senussi, Yasmeen, Cheng, Chi-An, Burgess, Eleanor, Edlow, Andrea G., Chou, Janet, Dionne, Audrey, Balaguru, Duraisamy, Lahoud-Rahme, Manuella, Arditi, Moshe, Julg, Boris, Randolph, Adrienne G., Alter, Galit, Fasano, Alessio, and Walt, David R.

Published
2023
Full Text
View/download PDF

8. IgG Fc N-Glycosylation Translates MHCII Haplotype into Autoimmune Skin Disease

Author

Clauder, Ann-Katrin, Kordowski, Anna, Bartsch, Yannic C., Köhl, Gabriele, Lilienthal, Gina-Maria, Almeida, Larissa N., Lindemann, Timo, Petry, Janina, Rau, Christina N., Gramalla-Schmitz, Anna, Dühring, Lara, Elbracht, Claudia, Kenno, Samyr, Tillmann, Jenny, Wuhrer, Manfred, Ludwig, Ralf J., Ibrahim, Saleh M., Bieber, Katja, Köhl, Jörg, Ehlers, Marc, and Manz, Rudolf Armin

Published
2021
Full Text
View/download PDF

9. Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

Author

Kaneko, Naoki, Kuo, Hsiao-Hsuan, Boucau, Julie, Farmer, Jocelyn R., Allard-Chamard, Hugues, Mahajan, Vinay S., Piechocka-Trocha, Alicja, Lefteri, Kristina, Osborn, Matthew, Bals, Julia, Bartsch, Yannic C., Bonheur, Nathalie, Caradonna, Timothy M., Chevalier, Josh, Chowdhury, Fatema, Diefenbach, Thomas J., Einkauf, Kevin, Fallon, Jon, Feldman, Jared, Finn, Kelsey K., Garcia-Broncano, Pilar, Hartana, Ciputra Adijaya, Hauser, Blake M., Jiang, Chenyang, Kaplonek, Paulina, Karpell, Marshall, Koscher, Eric C., Lian, Xiaodong, Liu, Hang, Liu, Jinqing, Ly, Ngoc L., Michell, Ashlin R., Rassadkina, Yelizaveta, Seiger, Kyra, Sessa, Libera, Shin, Sally, Singh, Nishant, Sun, Weiwei, Sun, Xiaoming, Ticheli, Hannah J., Waring, Michael T., Zhu, Alex L., Alter, Galit, Li, Jonathan Z., Lingwood, Daniel, Schmidt, Aaron G., Lichterfeld, Mathias, Walker, Bruce D., Yu, Xu G., Padera, Robert F., Jr., and Pillai, Shiv

Published
2020
Full Text
View/download PDF

10. Humoral signatures of protective and pathological SARS-CoV-2 infection in children

Author

Bartsch, Yannic C., Wang, Chuangqi, Zohar, Tomer, Fischinger, Stephanie, Atyeo, Caroline, Burke, John S., and Kang, Jaewon

Subjects
Epidemics -- Demographic aspects -- Genetic aspects -- Complications and side effects, Biological sciences, Health
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience largely asymptomatic disease, with rare reports of multisystem inflammatory syndrome in children (MIS-C). Identifying immune mechanisms that result in these disparate clinical phenotypes in children could provide critical insights into coronavirus disease 2019 (COVID-19) pathogenesis. Using systems serology, in this study we observed in 25 children with acute mild COVID-19 a functional phagocyte and complement-activating IgG response to SARS-CoV-2, similar to the acute responses generated in adults with mild disease. Conversely, IgA and neutrophil responses were significantly expanded in adults with severe disease. Moreover, weeks after the resolution of SARS-CoV-2 infection, children who develop MIS-C maintained highly inflammatory monocyte-activating SARS-CoV-2 IgG antibodies, distinguishable from acute disease in children but with antibody levels similar to those in convalescent adults. Collectively, these data provide unique insights into the potential mechanisms of IgG and IgA that might underlie differential disease severity as well as unexpected complications in children infected with SARS-CoV-2. A study of multisystem inflammatory syndrome in children (MIS-C) shows maintenance of elevated levels of monocyte-activating pathogen-specific IgG not seen in children infected with SARS-CoV-2 who do not develop MIS-C., Author(s): Yannic C. Bartsch [sup.1] , Chuangqi Wang [sup.2] , Tomer Zohar [sup.1] [sup.2] , Stephanie Fischinger [sup.1] , Caroline Atyeo [sup.1] , John S. Burke [sup.1] , Jaewon Kang [...]

Published
2021
Full Text
View/download PDF

11. IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants

Author

Bartsch, Yannic C., Eschweiler, Simon, Leliavski, Alexei, Lunding, Hanna B., Wagt, Sander, Petry, Janina, Lilienthal, Gina-Maria, Rahmöller, Johann, de Haan, Noortje, Hölscher, Alexandra, Erapaneedi, Raghu, Giannou, Anastasios D., Aly, Lilian, Sato, Ryota, de Neef, Louise A., Winkler, André, Braumann, Dominique, Hobusch, Juliane, Kuhnigk, Kyra, Krémer, Vanessa, Steinhaus, Moritz, Blanchard, Véronique, Gemoll, Timo, Habermann, Jens K., Collin, Mattias, Salinas, Gabriela, Manz, Rudolf A., Fukuyama, Hidehiro, Korn, Thomas, Waisman, Ari, Yogev, Nir, Huber, Samuel, Rabe, Björn, Rose-John, Stefan, Busch, Hauke, Berberich-Siebelt, Friederike, Hölscher, Christoph, Wuhrer, Manfred, and Ehlers, Marc

Published
2020
Full Text
View/download PDF

12. Standardised quantitative assays for anti-SARS-CoV-2 immune response used in vaccine clinical trials by the CEPI Centralized Laboratory Network: a qualification analysis

Author

Manak, Mark, primary, Gagnon, Luc, additional, Phay-Tran, Steven, additional, Levesque-Damphousse, Philipa, additional, Fabie, Aymeric, additional, Daugan, Matthieu, additional, Khan, Sarwat Tahsin, additional, Proud, Pamela, additional, Hussey, Bethan, additional, Knott, Daniel, additional, Charlton, Sue, additional, Hallis, Bassam, additional, Medigeshi, Guruprasad K, additional, Garg, Neha, additional, Anantharaj, Anbalagan, additional, Raqib, Rubhana, additional, Sarker, Protim, additional, Alam, Mohammad Mamun, additional, Rahman, Mustafizur, additional, Murreddu, Marta, additional, Balgobind, Angela, additional, Hofman, Rick, additional, Grappi, Silvia, additional, Coluccio, Rosa, additional, Calandro, Pierpaolo, additional, Montomoli, Emanuele, additional, Mattiuzzo, Giada, additional, Prior, Sandra, additional, Le Duff, Yann, additional, Page, Mark, additional, Mitchell, Jane, additional, Schwartz, Lauren M, additional, Bartsch, Yannic C, additional, Azizi, Ali, additional, Bernasconi, Valentina, additional, Zala, Vijay, additional, De Almeida, Ana Paula, additional, Fassoulas, Helen, additional, Agrawal, Tanvi, additional, Singh, Janmejay, additional, Roy, Anjan Kumar, additional, Berndsen, Saskia, additional, de Mooij, Marina, additional, Buitendijk, Hester, additional, Stalpers, Coen, additional, Jarju, Modou, additional, Battistella, Filippo, additional, Jeeninga, Rienk, additional, Duijsings, Danny, additional, Razzano, Ilaria, additional, Molesti, Eleonora, additional, Mazzini, Livia, additional, Boccuto, Adele, additional, Holder, Angela, additional, Mee, Edward, additional, Hurley, Matthew, additional, Padley, Jennifer, additional, Rose, Nicola, additional, Gorman, Trina, additional, Vila-Belda, Jose, additional, James, Hannah, additional, and Carless, Jerome, additional

Published
2024
Full Text
View/download PDF

13. Discrete SARS-CoV-2 antibody titers track with functional humoral stability

Author

Bartsch, Yannic C., Fischinger, Stephanie, Siddiqui, Sameed M., Chen, Zhilin, Yu, Jingyou, Gebre, Makda, Atyeo, Caroline, Gorman, Matthew J., Zhu, Alex Lee, Kang, Jaewon, Burke, John S., Slein, Matthew, Gluck, Matthew J., Beger, Samuel, Hu, Yiyuan, Rhee, Justin, Petersen, Eric, Mormann, Benjamin, Aubin, Michael de St, Hasdianda, Mohammad A., Jambaulikar, Guruprasad, Boyer, Edward W., Sabeti, Pardis C., Barouch, Dan H., Julg, Boris D., Musk, Elon R., Menon, Anil S., Lauffenburger, Douglas A., Nilles, Eric J., and Alter, Galit

Published
2021
Full Text
View/download PDF

14. Vaccine-induced antibody Fc-effector functions in humans immunized with a combination Ad26.RSV.preF/RSV preF protein vaccine

Author

Bartsch, Yannic C., primary, Cizmeci, Deniz, additional, Yuan, Dansu, additional, Mehta, Nickita, additional, Tolboom, Jeroen, additional, De Paepe, Els, additional, van Heesbeen, Roy, additional, Sadoff, Jerald, additional, Comeaux, Christy A., additional, Heijnen, Esther, additional, Callendret, Benoit, additional, Alter, Galit, additional, and Bastian, Arangassery Rosemary, additional

Published
2023
Full Text
View/download PDF

16. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

Author

Yonker, Lael M., Gilboa, Tal, Ogata, Alana F., Senussi, Yasmeen, Lazarovits, Roey, Boribong, Brittany P., Bartsch, Yannic C., Loiselle, Maggie, Rivas, Magali Noval, Porrit, Rebecca A., Lima, Rosiane, Davis, Jameson P., Farkas, Eva J., Burns, Madeleine D., Young, Nicola, Mahajan, Vinay S., Hajizadeh, Soroush, Lopez, Xcanda I. Herrera, Kreuzer, Johannes, Morris, Robert, Martinez, Enid E., Han, Isaac, Griswold, Kettner, Jr., Barry, Nicholas C., Thompson, David B., Church, George, Edlow, Andrea G., Haas, Wilhelm, Pillai, Shiv, Arditi, Moshe, Alter, Galit, Walt, David R., and Fasano, Alessio

Subjects
Gastrointestinal mucosa -- Health aspects -- Physiological aspects, Membrane proteins -- Health aspects -- Physiological aspects, Pediatric research, Health care industry
Abstract

BACKGROUND. Weeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in children (MIS-C). Gastrointestinal (GI) symptoms are common in patients with MIS-C, and a severe hyperinflammatory response ensues with potential for cardiac complications. The cause of MIS-C has not been identified to date. METHODS. Here, we analyzed biospecimens from 100 children: 19 with MIS-C, 26 with acute COVID-19, and 55 controls. Stools were assessed for SARS-CoV-2 by reverse transcription PCR (RT-PCR), and plasma was examined for markers of breakdown of mucosal barrier integrity, including zonulin. Ultrasensitive antigen detection was used to probe for SARS-CoV-2 antigenemia in plasma, and immune responses were characterized. As a proof of concept, we treated a patient with MIS-C with larazotide, a zonulin antagonist, and monitored the effect on antigenemia and the patient's clinical response. RESULTS. We showed that in children with MIS-C, a prolonged presence of SARS-CoV-2 in the GI tract led to the release of zonulin, a biomarker of intestinal permeability, with subsequent trafficking of SARS-CoV-2 antigens into the bloodstream, leading to hyperinflammation. The patient with MIS-C treated with larazotide had a coinciding decrease in plasma SARSCoV-2 spike antigen levels and inflammatory markers and a resultant clinical improvement above that achieved with currently available treatments. CONCLUSION. These mechanistic data on MIS-C pathogenesis provide insight into targets for diagnosing, treating, and preventing MIS-C, which are urgently needed for this increasingly common severe COVID-19-related disease in children., Introduction Most children who are acutely infected with SARS-CoV-2 develop mild upper respiratory symptoms or experience asymptomatic infection. Several days to weeks after resolution of the initial infection, some of [...]

Published
2021
Full Text
View/download PDF

17. Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Author

Vorobyev, Artem, Gupta, Yask, Sezin, Tanya, Koga, Hiroshi, Bartsch, Yannic C., Belheouane, Meriem, Künzel, Sven, Sina, Christian, Schilf, Paul, Körber-Ahrens, Heiko, Beltsiou, Foteini, Lara Ernst, Anna, Khil’chenko, Stanislav, Al-Aasam, Hassanin, Manz, Rudolf A., Diehl, Sandra, Steinhaus, Moritz, Jascholt, Joanna, Kouki, Phillip, Boehncke, Wolf-Henning, Mayadas, Tanya N., Zillikens, Detlef, Sadik, Christian D., Nishi, Hiroshi, Ehlers, Marc, Möller, Steffen, Bieber, Katja, Baines, John F., Ibrahim, Saleh M., and Ludwig, Ralf J.

Published
2019
Full Text
View/download PDF

18. Sialylation of IgE reduces FcεRIα interaction and mast cell and basophil activation in vitro and increases IgE half‐life in vivo

Author

Dühring, Lara, primary, Petry, Janina, additional, Lilienthal, Gina‐Maria, additional, Bartsch, Yannic C., additional, Kubiak, Marie, additional, Pfeufer, Clarissa, additional, Lehrian, Selina, additional, Buhre, Jana S., additional, Lunding, Hanna B., additional, Kern, Carsten, additional, Behrends, Jochen, additional, Walsemann, Theresa, additional, Gädert, Leonie, additional, Sommer, Charline, additional, Krüger, Lynn, additional, Blanchard, Véronique, additional, Dehmel, Susann, additional, Jappe, Uta, additional, Rahmöller, Johann, additional, and Ehlers, Marc, additional

Published
2023
Full Text
View/download PDF

19. Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children

Author

Boribong, Brittany P., primary, LaSalle, Thomas J., additional, Bartsch, Yannic C., additional, Ellett, Felix, additional, Loiselle, Maggie E., additional, Davis, Jameson P., additional, Gonye, Anna L.K., additional, Sykes, David B., additional, Hajizadeh, Soroush, additional, Kreuzer, Johannes, additional, Pillai, Shiv, additional, Haas, Wilhelm, additional, Edlow, Andrea G., additional, Fasano, Alessio, additional, Alter, Galit, additional, Irimia, Daniel, additional, Sade-Feldman, Moshe, additional, and Yonker, Lael M., additional

Published
2022
Full Text
View/download PDF

20. SARS-CoV-2 mRNA vaccination elicits robust antibody responses in children

Author

Bartsch, Yannic C., primary, St. Denis, Kerri J., additional, Kaplonek, Paulina, additional, Kang, Jaewon, additional, Lam, Evan C., additional, Burns, Madeleine D., additional, Farkas, Eva J., additional, Davis, Jameson P., additional, Boribong, Brittany P., additional, Edlow, Andrea G., additional, Fasano, Alessio, additional, Shreffler, Wayne G., additional, Zavadska, Dace, additional, Johnson, Marina, additional, Goldblatt, David, additional, Balazs, Alejandro B., additional, Yonker, Lael M, additional, and Alter, Galit, additional

Published
2022
Full Text
View/download PDF

21. Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

Author

Epp, Alexandra, Hobusch, Juliane, Bartsch, Yannic C., Petry, Janina, Lilienthal, Gina-Maria, Koeleman, Carolien A.M., Eschweiler, Simon, Möbs, Christian, Hall, Ashley, Morris, Suzanne C., Braumann, Dominique, Engellenner, Christine, Bitterling, Josephine, Rahmöller, Johann, Leliavski, Alexei, Thurmann, Robina, Collin, Mattias, Moremen, Kelley W., Strait, Richard T., Blanchard, Véronique, Petersen, Arnd, Gemoll, Timo, Habermann, Jens K., Petersen, Frank, Nandy, Andreas, Kahlert, Helga, Hertl, Michael, Wuhrer, Manfred, Pfützner, Wolfgang, Jappe, Uta, Finkelman, Fred D., and Ehlers, Marc

Published
2018
Full Text
View/download PDF

23. A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection

Author

Routhu, Nanda Kishore, primary, Gangadhara, Sailaja, additional, Lai, Lilin, additional, Davis-Gardner, Meredith E., additional, Floyd, Katharine, additional, Shiferaw, Ayalnesh, additional, Bartsch, Yannic C., additional, Fischinger, Stephanie, additional, Khoury, Georges, additional, Rahman, Sheikh Abdul, additional, Stampfer, Samuel David, additional, Schäfer, Alexandra, additional, Jean, Sherrie M., additional, Wallace, Chelsea, additional, Stammen, Rachelle L., additional, Wood, Jennifer, additional, Joyce, Cohen, additional, Nagy, Tamas, additional, Parsons, Matthew S., additional, Gralinski, Lisa, additional, Kozlowski, Pamela A., additional, Alter, Galit, additional, Suthar, Mehul S., additional, and Amara, Rama Rao, additional

Published
2022
Full Text
View/download PDF

25. Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines

Author

Bartsch, Yannic C., primary, Tong, Xin, additional, Kang, Jaewon, additional, Avendaño, María José, additional, Serrano, Eileen F., additional, García-Salum, Tamara, additional, Pardo-Roa, Catalina, additional, Riquelme, Arnoldo, additional, Cai, Yongfei, additional, Renzi, Isabella, additional, Stewart-Jones, Guillaume, additional, Chen, Bing, additional, Medina, Rafael A., additional, and Alter, Galit, additional

Published
2022
Full Text
View/download PDF

26. Differential Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Profiles After Allergic Reactions to Messenger RNA Coronavirus Disease 2019 Vaccine

Author

Maron, Jenny S, primary, Conroy, Michelle, additional, Naranbai, Vivek, additional, Samarakoon, Upeka, additional, Motazedi, Tina, additional, Farmer, Jocelyn R, additional, Freeman, Esther, additional, Banerji, Aleena, additional, Bartsch, Yannic C, additional, Gregory, David J, additional, Poznansky, Mark C, additional, Alter, Galit, additional, and Blumenthal, Kimberly G, additional

Published
2022
Full Text
View/download PDF

27. Durability and Cross-Reactivity of SARS-CoV-2 mRNA Vaccine in Adolescent Children

Author

Burns, Madeleine D., primary, Boribong, Brittany P., additional, Bartsch, Yannic C., additional, Loiselle, Maggie, additional, St. Denis, Kerri J., additional, Sheehan, Maegan L., additional, Chen, Jessica W., additional, Davis, Jameson P., additional, Lima, Rosiane, additional, Edlow, Andrea G., additional, Fasano, Alessio, additional, Balazs, Alejandro B., additional, Alter, Galit, additional, and Yonker, Lael M., additional

Published
2022
Full Text
View/download PDF

29. Serological Markers of SARS-CoV-2 Reinfection

Author

Siddiqui, Sameed M., primary, Bowman, Kathryn A., additional, Zhu, Alex L., additional, Fischinger, Stephanie, additional, Beger, Samuel, additional, Maron, Jenny S., additional, Bartsch, Yannic C., additional, Atyeo, Caroline, additional, Gorman, Matthew J., additional, Yanis, Ahmad, additional, Hultquist, Judd F., additional, Lorenzo-Redondo, Ramon, additional, Ozer, Egon A., additional, Simons, Lacy M., additional, Talj, Rana, additional, Rankin, Danielle A., additional, Chapman, Lindsay, additional, Meade, Kyle, additional, Steinhart, Jordan, additional, Mullane, Sean, additional, Siebert, Suzanne, additional, Streeck, Hendrik, additional, Sabeti, Pardis, additional, Halasa, Natasha, additional, Musk, Elon R., additional, Barouch, Dan H., additional, Menon, Anil S., additional, Nilles, Eric J., additional, Lauffenburger, Douglas A., additional, and Alter, Galit, additional

Published
2022
Full Text
View/download PDF

32. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

Author

Boribong, Brittany Phatana, primary, LaSalle, Thomas James, additional, Bartsch, Yannic C., additional, Ellett, Felix, additional, Loiselle, Maggie E., additional, Davis, Jameson P., additional, Gonye, Anna L. K., additional, Hajizadeh, Soroush, additional, Kreuzer, Johannes, additional, Pillai, Shiv, additional, Haas, Wilhelm, additional, Edlow, Andrea, additional, Fasano, Alessio, additional, Alter, Galit, additional, Irimia, Daniel, additional, Sade-Feldman, Moshe, additional, and Yonker, Lael M., additional

Published
2022
Full Text
View/download PDF

33. Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

Author

Boribong, Brittany P., primary, LaSalle, Thomas J., additional, Bartsch, Yannic C., additional, Ellett, Felix, additional, Loiselle, Maggie E., additional, Davis, Jameson P., additional, Gonye, Anna L. K., additional, Hajizadeh, Soroush, additional, Kreuzer, Johannes, additional, Pillai, Shiv, additional, Haas, Wilhelm, additional, Edlow, Andrea, additional, Fasano, Alessio, additional, Alter, Galit, additional, Irimia, Daniel, additional, Sade-Feldman, Moshe, additional, and Yonker, Lael M., additional

Published
2021
Full Text
View/download PDF

34. Epidemiological and Immunological Features of Obesity and SARS-CoV-2

Author

Nilles, Eric J., primary, Siddiqui, Sameed M., additional, Fischinger, Stephanie, additional, Bartsch, Yannic C., additional, de St. Aubin, Michael, additional, Zhou, Guohai, additional, Gluck, Matthew J., additional, Berger, Samuel, additional, Rhee, Justin, additional, Petersen, Eric, additional, Mormann, Benjamin, additional, Loesche, Michael, additional, Hu, Yiyuan, additional, Chen, Zhilin, additional, Yu, Jingyou, additional, Gebre, Makda, additional, Atyeo, Caroline, additional, Gorman, Matthew J., additional, Zhu, Alex Lee, additional, Burke, John, additional, Slein, Matthew, additional, Hasdianda, Mohammad A., additional, Jambaulikar, Guruprasad, additional, Boyer, Edward W., additional, Sabeti, Pardis C., additional, Barouch, Dan H., additional, Julg, Boris, additional, Kucharski, Adam J., additional, Musk, Elon R., additional, Lauffenburger, Douglas A., additional, Alter, Galit, additional, and Menon, Anil S., additional

Published
2021
Full Text
View/download PDF

35. Comprehensive antibody profiling of mRNA vaccination in children

Author

Bartsch, Yannic C, primary, St Denis, Kerri J, additional, Kaplonek, Paulina, additional, Kang, Jaewon, additional, Lam, Evan C., additional, Burns, Madeleine D, additional, Farkas, Eva J, additional, Davis, Jameson P, additional, Boribong, Brittany P, additional, Edlow, Andrea G, additional, Fasano, Alessio, additional, Shreffler, Wayne, additional, Zavadska, Dace, additional, Johnson, Marina, additional, Goldblatt, David, additional, Balazs, Alejandro B, additional, Yonker, Lael M, additional, and Alter, Galit, additional

Published
2021
Full Text
View/download PDF

37. Humoral signatures of protective and pathological SARS-CoV-2 infection in children

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Bartsch, Yannic C., Wang, Chuangqi, Zohar, Tomer, Fischinger, Stephanie, Atyeo, Caroline, Burke, John S., Kang, Jaewon, Edlow, Andrea G., Fasano, Alessio, Baden, Lindsey R., Nilles, Eric J., Woolley, Ann E., Karlson, Elizabeth W., Hopke, Alex R., Irimia, Daniel, Fischer, Eric S., Ryan, Edward T., Charles, Richelle C., Julg, Boris D., Lauffenburger, Douglas A, Yonker, Lael M., Alter, Galit, Massachusetts Institute of Technology. Department of Biological Engineering, Bartsch, Yannic C., Wang, Chuangqi, Zohar, Tomer, Fischinger, Stephanie, Atyeo, Caroline, Burke, John S., Kang, Jaewon, Edlow, Andrea G., Fasano, Alessio, Baden, Lindsey R., Nilles, Eric J., Woolley, Ann E., Karlson, Elizabeth W., Hopke, Alex R., Irimia, Daniel, Fischer, Eric S., Ryan, Edward T., Charles, Richelle C., Julg, Boris D., Lauffenburger, Douglas A, Yonker, Lael M., and Alter, Galit

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience largely asymptomatic disease, with rare reports of multisystem inflammatory syndrome in children (MIS-C). Identifying immune mechanisms that result in these disparate clinical phenotypes in children could provide critical insights into coronavirus disease 2019 (COVID-19) pathogenesis. Using systems serology, in this study we observed in 25 children with acute mild COVID-19 a functional phagocyte and complement-activating IgG response to SARS-CoV-2, similar to the acute responses generated in adults with mild disease. Conversely, IgA and neutrophil responses were significantly expanded in adults with severe disease. Moreover, weeks after the resolution of SARS-CoV-2 infection, children who develop MIS-C maintained highly inflammatory monocyte-activating SARS-CoV-2 IgG antibodies, distinguishable from acute disease in children but with antibody levels similar to those in convalescent adults. Collectively, these data provide unique insights into the potential mechanisms of IgG and IgA that might underlie differential disease severity as well as unexpected complications in children infected with SARS-CoV-2., National Institute for Allergy and Infectious Diseases (Grant U19 AI135995), NIH (Grants 3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, U19AI42790-01, CIVIC75N93019C00052, U01CA260476), Gates Foundation (Grant OPP1146996)

Published
2021

38. Epidemiological and Immunological Features of Obesity and SARS-CoV-2

Author

Nilles, Eric J., Siddiqui, Sameed M., Fischinger, Stephanie, Bartsch, Yannic C., de St. Aubin, Michael, Zhou, Guohai, Gluck, Matthew J., Berger, Samuel, Rhee, Justin, Petersen, Eric, Mormann, Benjamin, Loesche, Michael, Hu, Yiyuan, Chen, Zhilin, Yu, Jingyou, Gebre, Makda, Atyeo, Caroline, Gorman, Matthew J., Zhu, Alex Lee, Burke, John, Nilles, Eric J., Siddiqui, Sameed M., Fischinger, Stephanie, Bartsch, Yannic C., de St. Aubin, Michael, Zhou, Guohai, Gluck, Matthew J., Berger, Samuel, Rhee, Justin, Petersen, Eric, Mormann, Benjamin, Loesche, Michael, Hu, Yiyuan, Chen, Zhilin, Yu, Jingyou, Gebre, Makda, Atyeo, Caroline, Gorman, Matthew J., Zhu, Alex Lee, and Burke, John

Abstract

Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.

Published
2021

39. Discrete SARS-CoV-2 antibody titers track with functional humoral stability

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Bartsch, Yannic C., Fischinger, Stephanie, Siddiqui, Sameed M., Chen, Zhilin, Yu, Jingyou, Gebre, Makda, Atyeo, Caroline, Gorman, Matthew J., Zhu, Alex Lee, Kang, Jaewon, Burke, John S., Slein, Matthew, Gluck, Matthew J., Beger, Samuel, Hu, Yiyuan, Rhee, Justin, Petersen, Eric, Mormann, Benjamin, Aubin, Michael de St, Hasdianda, Mohammad A., Jambaulikar, Guruprasad, Boyer, Edward W., Sabeti, Pardis C., Barouch, Dan H., Julg, Boris D., Musk, Elon R., Menon, Anil S., Lauffenburger, Douglas A, Nilles, Eric J., Alter, Galit, Massachusetts Institute of Technology. Department of Biological Engineering, Bartsch, Yannic C., Fischinger, Stephanie, Siddiqui, Sameed M., Chen, Zhilin, Yu, Jingyou, Gebre, Makda, Atyeo, Caroline, Gorman, Matthew J., Zhu, Alex Lee, Kang, Jaewon, Burke, John S., Slein, Matthew, Gluck, Matthew J., Beger, Samuel, Hu, Yiyuan, Rhee, Justin, Petersen, Eric, Mormann, Benjamin, Aubin, Michael de St, Hasdianda, Mohammad A., Jambaulikar, Guruprasad, Boyer, Edward W., Sabeti, Pardis C., Barouch, Dan H., Julg, Boris D., Musk, Elon R., Menon, Anil S., Lauffenburger, Douglas A, Nilles, Eric J., and Alter, Galit

Abstract

Antibodies serve as biomarkers of infection, but if sustained can confer long-term immunity. Yet, for most clinically approved vaccines, binding antibody titers only serve as a surrogate of protection. Instead, the ability of vaccine induced antibodies to neutralize or mediate Fc-effector functions is mechanistically linked to protection. While evidence has begun to point to persisting antibody responses among SARS-CoV-2 infected individuals, cases of re-infection have begun to emerge, calling the protective nature of humoral immunity against this highly infectious pathogen into question. Using a community-based surveillance study, we aimed to define the relationship between titers and functional antibody activity to SARS-CoV-2 over time. Here we report significant heterogeneity, but limited decay, across antibody titers amongst 120 identified seroconverters, most of whom had asymptomatic infection. Notably, neutralization, Fc-function, and SARS-CoV-2 specific T cell responses were only observed in subjects that elicited RBD-specific antibody titers above a threshold. The findings point to a switch-like relationship between observed antibody titer and function, where a distinct threshold of activity—defined by the level of antibodies—is required to elicit vigorous humoral and cellular response. This response activity level may be essential for durable protection, potentially explaining why re-infections occur with SARS-CoV-2 and other common coronaviruses., NIH (Grants 3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, U19AI42790-01, 1U01CA260476 – 01, CIVIC75N93019C00052), Gates Foundation (Grants OPP1146996 and INV-001650), NASA (Contract NNX16AO69A), National Institute for Allergy and Infectious Disease (Grant U19 AI135995)

Published
2021

40. Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features

Author

Bartsch, Yannic C., primary, Loos, Carolin, additional, Rossignol, Evan, additional, Fajnzylber, Jesse M., additional, Yuan, Dansu, additional, Avihingsanon, Anchalee, additional, Ubolyam, Sasiwimol, additional, Jupimai, Thidarat, additional, Hirschel, Bernard, additional, Ananworanich, Jintanat, additional, Lauffenburger, Douglas A., additional, Li, Jonathan Z., additional, Alter, Galit, additional, and Julg, Boris, additional

Published
2021
Full Text
View/download PDF

41. Resilient Fc-Effector Functions Across SARS-CoV-2 Variants of Concern Following mRNA-1273 Vaccination

Author

Kaplonek, Paulina, primary, Fischinger, Stephanie, additional, Cizmeci, Deniz, additional, Bartsch, Yannic C., additional, Kang, Jaewon, additional, Burke, John S., additional, Shin, Sally A., additional, Dayal, Diana, additional, Martin, Patrick, additional, Mann, Colin, additional, Amanat, Fatima, additional, Julg, Boris, additional, Nilles, Eric J., additional, Musk, Elon R., additional, Menon, Anil S., additional, Krammer, Florian, additional, Saphire, Erica Ollmann, additional, Carfi, Andrea, additional, and Alter, Galit, additional

Published
2021
Full Text
View/download PDF

42. Epidemiological and immunological features of obesity and SARS-CoV-2

Author

Nilles, Eric J, primary, Siddiqui, Sameed M, additional, Fischinger, Stephanie, additional, Bartsch, Yannic C, additional, de Saint Aubin, Michael, additional, Zhou, Guohai, additional, Gluck, Matthew J, additional, Berger, Samuel, additional, Rhee, Justin, additional, Petersen, Eric, additional, Mormann, Benjamin, additional, Loesche, Michael, additional, Chen, Zhilin, additional, Yu, Jingyou, additional, Gebre, Makda, additional, Atyeo, Caroline, additional, Gorman, Matthew J, additional, Zhu, Alex Lee, additional, Burke, John, additional, Slein, Matthew, additional, Hasdianda, Mohammad A, additional, Jambaulikar, Guruprasad, additional, Boyer, Edward, additional, Sabeti, Pardis, additional, Barouch, Dan H, additional, Julg, Boris D, additional, Kucharski, Adam J, additional, Musk, Elon R, additional, Lauffenburger, Douglas A, additional, Alter, Galit, additional, and Menon, Anil S, additional

Published
2020
Full Text
View/download PDF

43. The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19

Author

Kaneko, Naoki, primary, Kuo, Hsiao-Hsuan, additional, Boucau, Julie, additional, Farmer, Jocelyn R., additional, Allard-Chamard, Hugues, additional, Mahajan, Vinay S., additional, Piechocka-Trocha, Alicja, additional, Lefteri, Kristina, additional, Osborn, Matt, additional, Bals, Julia, additional, Bartsch, Yannic C., additional, Bonheur, Nathalie, additional, Caradonna, Timothy M., additional, Chevalier, Josh, additional, Chowdhury, Fatema, additional, Diefenbach, Thomas J., additional, Einkauf, Kevin, additional, Fallon, Jon, additional, Feldman, Jared, additional, Finn, Kelsey K., additional, Garcia-Broncano, Pilar, additional, Hartana, Ciputra Adijaya, additional, Hauser, Blake M., additional, Jiang, Chenyang, additional, Kaplonek, Paulina, additional, Karpell, Marshall, additional, Koscher, Eric C., additional, Lian, Xiaodong, additional, Liu, Hang, additional, Liu, Jinqing, additional, Ly, Ngoc L., additional, Michell, Ashlin R., additional, Rassadkina, Yelizaveta, additional, Seiger, Kyra, additional, Sessa, Libera, additional, Shin, Sally, additional, Singh, Nishant, additional, Sun, Weiwei, additional, Sun, Xiaoming, additional, Ticheli, Hannah J., additional, Waring, Michael T., additional, Zhu, Alex L., additional, Li, Jonathan, additional, Lingwood, Daniel, additional, Schmidt, Aaron G., additional, Lichterfeld, Matthias, additional, Walker, Bruce D., additional, Yu, Xu, additional, Padera, Robert F., additional, Pillai, Shiv, additional, and Group, Massachusetts Consortium on Pathoge, additional

Published
2020
Full Text
View/download PDF

44. Sialylated autoantigen-reactive IgG antibodies attenuate disease development in mouse models of lupus nephritis and rheumatoid arthritis

Author

Rahmöller, Johann, Bartsch, Yannic C., Leliavski, Alexei, Lilienthal, Gina-Maria, Petry, Janina, and Ehlers, Marc

Abstract

Pro- and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; G0) IgG Abs in the serum of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients reflects severity of the diseases. In contrast, sialylated IgG Abs are responsible for anti-inflammatory effects of the intravenous immunoglobulin (IVIG; pooled human serum IgG from healthy donors), administered in high doses (2 g/kg) to treat autoimmune patients. However, whether low amounts of sialylated autoantigen-reactive IgG Abs can also inhibit autoimmune diseases has been hardly investigated. Here, we explored whether sialylated autoantigen-reactive IgG Abs can inhibit autoimmune pathology in two mouse models (Bartsch et al., Front. Immunol. 2018; 9:1183). We found that sialylated IgG autoantibodies fail to induce inflammation and lupus nephritis in a B cell receptor (BCR) transgenic lupus model, but instead are associated with lower frequencies of pathogenic Th1, Th17 and B cell responses. In accordance, the transfer of small amounts of immune complexes containing sialylated IgG Abs was sufficient to attenuate the development of nephritis. We further showed that administration of sialylated collagen type II (Col II)-specific IgG Abs attenuated the disease symptoms in a model of Col II-induced arthritis and reduced pathogenic Th17 cell and autoantigen-specific IgG Ab responses. We conclude that sialylated autoantigen-specific IgG Abs may represent a promising tool for treating pathogenic T and B cell immune responses in autoimmune diseases., Advances in RAB Research, Vol 1 No 1 (2018)

Published
2018
Full Text
View/download PDF

46. Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis

Author

Bartsch, Yannic C., primary, Rahmöller, Johann, additional, Mertes, Maria M. M., additional, Eiglmeier, Susanne, additional, Lorenz, Felix K. M., additional, Stoehr, Alexander D., additional, Braumann, Dominique, additional, Lorenz, Alexandra K., additional, Winkler, André, additional, Lilienthal, Gina-Maria, additional, Petry, Janina, additional, Hobusch, Juliane, additional, Steinhaus, Moritz, additional, Hess, Constanze, additional, Holecska, Vivien, additional, Schoen, Carolin T., additional, Oefner, Carolin M., additional, Leliavski, Alexei, additional, Blanchard, Véronique, additional, and Ehlers, Marc, additional

Published
2018
Full Text
View/download PDF

48. A single glycan on IgE is indispensable for initiation of anaphylaxis

Author

Shade, Kai-Ting C., primary, Platzer, Barbara, additional, Washburn, Nathaniel, additional, Mani, Vinidhra, additional, Bartsch, Yannic C., additional, Conroy, Michelle, additional, Pagan, Jose D., additional, Bosques, Carlos, additional, Mempel, Thorsten R., additional, Fiebiger, Edda, additional, and Anthony, Robert M., additional

Published
2015
Full Text
View/download PDF

49. Anti-TNF therapy impairs both short- and long-term IgG responses after repeated vaccination.

Author

Buhre JS, Pongracz T, Geisen UM, Schubert M, Wang W, Nouta J, Obara M, Lehrian S, Rahmöller J, Petry J, Tran F, Schreiber S, Sümbül M, Berner D, Gerdes S, Schirmer J, Longardt AC, Hoff P, Kalinke U, Ludwig RJ, Bartsch YC, Hoyer BF, Wuhrer M, and Ehlers M

Abstract

Background: Recently, it has been questioned whether vaccination of patients with inflammatory (auto)immune diseases under anti-tumor necrosis factor (TNF) treatment leads to impaired vaccine-induced immune responses and protection against breakthrough infections. However, the effects of TNF blockade on short- and long-term immune responses after repeated vaccination remain unclear. Vaccination studies have shown that initial short-term IgG antibodies (Abs) carry highly galactosylated and sialylated Fc glycans, whilst long-term IgG Abs have low levels of galactosylation and sialylation and are most likely generated by long-lived plasma cells (PCs) derived primarily from the germinal center (GC) response. Thus, IgG Fc glycosylation patterns may be applicable to distinguish short- and long-term vaccine responses after repeated vaccination under the influence of anti-TNF treatment., Methods: We used COVID-19 vaccination as a model to investigate vaccine-induced IgG subclass levels and Fc glycosylation patterns, B cell subsets, and effector functions of short- and long-term Ab responses after up to three vaccinations in patients on anti-TNF or other immunosuppressive treatments and in healthy individuals. Using TriNetX, a global healthcare database, we determined the risk of SARS-CoV-2 breakthrough infections in vaccinated patients treated with anti-TNF or other immunosuppressive drugs., Results: Anti-TNF treatment reduced the long-term abundance of all anti-S IgG subclasses with low levels of galactosylation and sialylation. Re-activation of potential memory B cells initially generated highly galactosylated and sialylated IgG antibodies, which were progressively reduced after each booster dose in anti-TNF-treated patients, especially in the elderly. The reduced short- and long-term IgG (1) levels in anti-TNF-treated patients correlated with diminished functional activity and an increased risk for the development of COVID-19., Conclusions: The data suggest that anti-TNF treatment reduces both GC-dependent long-lived PCs and GC-dependent memory B cell-derived short-lived PCs, hence both the long- and short-term IgG subclass responses, respectively, after repeated vaccination. We propose that anti-TNF therapy, especially in the elderly, reduces the benefit of booster vaccination., (© 2024 The Author(s). Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Published
2024
Full Text
View/download PDF

50. Comprehensive antibody profiling of mRNA vaccination in children.

Author

Bartsch YC, St Denis KJ, Kaplonek P, Kang J, Lam EC, Burns MD, Farkas EJ, Davis JP, Boribong BP, Edlow AG, Fasano A, Shreffler W, Zavadska D, Johnson M, Goldblatt D, Balazs AB, Yonker LM, and Alter G

Abstract

While children have been largely spared from COVID-19 disease, the emergence of viral variants of concern (VOC) with increased transmissibility, combined with fluctuating mask mandates and school re-openings have led to increased infections and disease among children. Thus, there is an urgent need to roll out COVID-19 vaccines to children of all ages. However, whether children respond equivalently to adults to mRNA vaccines and whether dosing will elicit optimal immunity remains unclear. Given the recent announcement of incomplete immunity induced by the pediatric dose of the BNT162b2 vaccine in young children, here we aimed to deeply profile and compare the vaccine-induced humoral immune response in 6-11 year old children receiving the pediatric (50μg) or adult (100μg) dose of the mRNA-1273 vaccine compared to adults and naturally infected children or children that experienced multi inflammatory syndrome in children (MIS-C) for the first time. Children elicited an IgG dominant vaccine induced immune response, surpassing adults at a matched 100μg dose, but more variable immunity at a 50μg dose. Irrespective of titer, children generated antibodies with enhanced Fc-receptor binding capacity. Moreover, like adults, children generated cross-VOC humoral immunity, marked by a decline of omicron receptor binding domain-binding, but robustly preserved omicron Spike-receptor binding, with robustly preserved Fc-receptor binding capabilities, in a dose dependent manner. These data indicate that while both 50μg and 100μg of mRNA vaccination in children elicits robust cross-VOC antibody responses, 100ug of mRNA in children results in highly preserved omicron-specific functional humoral immunity., Competing Interests: Competing interests G.A. is a founder of Seromyx Systems, a company developing a platform technology that describes the antibody immune response. G.A.’s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies. All other authors have declared that no conflicts of interest exist.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results