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1. Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)

Author

Olsson, Ann, Bouaoun, Liacine, Schuz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jockel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernandez-Tardon, Guillermo, Zaridze, David, Field, John K., Lissowska, Jolanta, Swiatkowska, Beata, McLaughlin, John R., Demers, Paul A., Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pandics, Tamas, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Bruning, Thomas, Vlaanderen, Jelle, and Peters, Susan

Subjects
Statistics, Risk factors, Health aspects, Environmental aspects, Lung cancer -- Statistics -- Risk factors -- Environmental aspects, Carcinogens -- Statistics -- Health aspects -- Environmental aspects, Occupational exposure -- Statistics, Cocarcinogens -- Statistics -- Health aspects -- Environmental aspects, Occupational health and safety -- Statistics
Abstract

Introduction Occupational carcinogens represent a significant threat on worker's health, and exposed workers may be (simultaneously) exposed to more than one carcinogen. The European CAREX project estimated that 23% of [...], Background: While much research has been done to identify individual workplace lung carcinogens, little is known about joint effects on risk when workers are exposed to multiple agents. Objectives: We investigated the pairwise joint effects of occupational exposures to asbestos, respirable crystalline silica, metals (i.e., nickel, chromium-VI), and polycyclic aromatic hydrocarbons (PAH) on lung cancer risk, overall and by major histologic subtype, while accounting for cigarette smoking. Methods: In the international 14-center SYNERGY project, occupational exposures were assigned to 16,901 lung cancer cases and 20,965 control subjects using a quantitative job-exposure matrix (SYN-JEM). Odds ratios (ORs) and 95% confidence intervals (CIs) were computed for ever vs. never exposure using logistic regression models stratified by sex and adjusted for study center, age, and smoking habits. Joint effects among pairs of agents were assessed on multiplicative and additive scales, the latter by calculating the relative excess risk due to interaction (RERI). Results: All pairwise joint effects of lung carcinogens in men were associated with an increased risk of lung cancer. However, asbestos/metals and metals/PAH resulted in less than additive effects; while the chromium-VI/silica pair showed marginally synergistic effect in relation to adenocarcinoma (RERI: 0.24; CI: 0.02, 0.46; p = 0.05). In women, several pairwise joint effects were observed for small cell lung cancer including exposure to PAH/silica (OR = 5.12; CI: 1.77, 8.48), and to asbestos/silica (OR = 4.32; CI: 1.35, 7.29), where exposure to PAH/silica resulted in a synergistic effect (RERI: 3.45; CI: 0.10, 6.8). Discussion: Small or no deviation from additive or multiplicative effects was observed, but co-exposure to the selected lung carcinogens resulted generally in higher risk than exposure to individual agents, highlighting the importance to reduce and control exposure to carcinogens in workplaces and the general environment. https://doi.org/10.1289/EHP13380

Published
2024
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3. Socioeconomic Status, Smoking, and Lung Cancer: Mediation and Bias Analysis in the SYNERGY Study.

Author

Hovanec, Jan, Kendzia, Benjamin, Olsson, Ann, Schüz, Joachim, Kromhout, Hans, Vermeulen, Roel, Peters, Susan, Gustavsson, Per, Migliore, Enrica, Radoi, Loredana, Barul, Christine, Consonni, Dario, Caporaso, Neil E., Landi, Maria Teresa, Field, John K., Karrasch, Stefan, Wichmann, Heinz-Erich, Siemiatycki, Jack, Parent, Marie-Elise, and Richiardi, Lorenzo

Abstract

Background: Increased lung cancer risks for low socioeconomic status (SES) groups are only partially attributable to smoking habits. Little effort has been made to investigate the persistent risks related to low SES by quantification of potential biases. Methods: Based on 12 case–control studies, including 18 centers of the international SYNERGY project (16,550 cases, 20,147 controls), we estimated controlled direct effects (CDE) of SES on lung cancer via multiple logistic regression, adjusted for age, study center, and smoking habits and stratified by sex. We conducted mediation analysis by inverse odds ratio weighting to estimate natural direct effects and natural indirect effects via smoking habits. We considered misclassification of smoking status, selection bias, and unmeasured mediator–outcome confounding by genetic risk, both separately and by multiple quantitative bias analyses, using bootstrap to create 95% simulation intervals (SI). Results: Mediation analysis of lung cancer risks for SES estimated mean proportions of 43% in men and 33% in women attributable to smoking. Bias analyses decreased the direct effects of SES on lung cancer, with selection bias showing the strongest reduction in lung cancer risk in the multiple bias analysis. Lung cancer risks remained increased for lower SES groups, with higher risks in men (fourth vs. first [highest] SES quartile: CDE, 1.50 [SI, 1.32, 1.69]) than women (CDE: 1.20 [SI: 1.01, 1.45]). Natural direct effects were similar to CDE, particularly in men. Conclusions: Bias adjustment lowered direct lung cancer risk estimates of lower SES groups. However, risks for low SES remained elevated, likely attributable to occupational hazards or other environmental exposures. [ABSTRACT FROM AUTHOR]

Published
2025
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4. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships

Author

Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Abstract

OBJECTIVES: The quantitative job-exposure matrix SYN-JEM consists of various dimensions: job-specific estimates, region-specific estimates, and prior expert ratings of jobs by the semi-quantitative DOM-JEM. We analyzed the effect of different JEM dimensions on the exposure-response relationships between occupational silica exposure and lung cancer risk to investigate how these variations influence estimates of exposure by a quantitative JEM and associated health endpoints.METHODS: Using SYN-JEM, and alternative SYN-JEM specifications with varying dimensions included, cumulative silica exposure estimates were assigned to 16 901 lung cancer cases and 20 965 controls pooled from 14 international community-based case-control studies. Exposure-response relationships based on SYN-JEM and alternative SYN-JEM specifications were analyzed using regression analyses (by quartiles and log-transformed continuous silica exposure) and generalized additive models (GAM), adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk.RESULTS: SYN-JEM and alternative specifications generated overall elevated and similar lung cancer odds ratios ranging from 1.13 (1st quartile) to 1.50 (4th quartile). In the categorical and log-linear analyses SYN-JEM with all dimensions included yielded the best model fit, and exclusion of job-specific estimates from SYN-JEM yielded the poorest model fit. Additionally, GAM showed the poorest model fit when excluding job-specific estimates.CONCLUSION: The established exposure-response relationship between occupational silica exposure and lung cancer was marginally influenced by varying the dimensions of SYN-JEM. Optimized modelling of exposure-response relationships will be obtained when incorporating all relevant dimensions, namely prior rating, job, time, and region. Quantitative job-specific estimates appeared to be the most prominent dimens

Published
2024

5. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Author

Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, and Vermeulen, Roel

Abstract

Rationale: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. Objectives: We aimed to examine the relationship between occupational benzene exposure and lung cancer. Methods: Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes. Measurements and Main Results: Analyses included 28,048 subjects (12,329 cases, 15,719 control subjects). Lung cancer odds ratios ranged from 1.12 (95% confidence interval, 1.03–1.22) to 1.32 (95% confidence interval, 1.18–1.48) (Ptrend = 0.002) for groups with the lowest and highest cumulative occupational exposures, respectively, compared with unexposed subjects. We observed an increasing trend of lung cancer with longer duration of exposure (Ptrend , 0.001) and a decreasing trend with longer time since last exposure (Ptrend = 0.02). These effects were seen for all lung cancer subtypes, regardless of smoking status, and were not influenced by specific occupational groups, exposures, or studies. Conclusions: We found consistent and robust associations between different dimensions of occupational benzene exposure and lung cancer after adjusting for smoking and main occupational lung carcinogens. These associations were observed across different subgroups, including nonsmokers. Our findings support the hypothesis that occupational benzene exposure increases the risk of developing lung cancer. Consequently, there is a need to revisit published epidemiological and molecular data on the pulmonary carcinogenicity of benzene.

Published
2024

6. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships

Author

Planetary Health & Exposoom, Cancer, Circulatory Health, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Lissowska, Jolanta, Swiatkowska, Beata, Field, John K., McLaughlin, John R., Demers, Paul A., Pandics, Tamas, Forastiere, Franc Esco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, Planetary Health & Exposoom, Cancer, Circulatory Health, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E., Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Lissowska, Jolanta, Swiatkowska, Beata, Field, John K., McLaughlin, John R., Demers, Paul A., Pandics, Tamas, Forastiere, Franc Esco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Published
2024

7. Lung Cancer Risks Associated with Occupational Exposure to Pairs of Five Lung Carcinogens: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Olsson, Ann, Bouaoun, Liacine, Schüz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, Vlaanderen, Jelle, Peters, Susan, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Olsson, Ann, Bouaoun, Liacine, Schüz, Joachim, Vermeulen, Roel, Behrens, Thomas, Ge, Calvin, Kromhout, Hans, Siemiatycki, Jack, Gustavsson, Per, Boffetta, Paolo, Kendzia, Benjamin, Radoi, Loredana, Barul, Christine, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Pándics, Tamás, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Straif, Kurt, Brüning, Thomas, Vlaanderen, Jelle, and Peters, Susan

Published
2024

8. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, Vermeulen, Roel, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Wan, Wenxin, Peters, Susan, Portengen, Lützen, Olsson, Ann, Schüz, Joachim, Ahrens, Wolfgang, Schejbalova, Miriam, Boffetta, Paolo, Behrens, Thomas, Brüning, Thomas, Kendzia, Benjamin, Consonni, Dario, Demers, Paul A, Fabiánová, Eleonóra, Fernández-Tardón, Guillermo, Field, John K, Forastiere, Francesco, Foretova, Lenka, Guénel, Pascal, Gustavsson, Per, Jöckel, Karl-Heinz, Karrasch, Stefan, Landi, Maria Teresa, Lissowska, Jolanta, Barul, Christine, Mates, Dana, McLaughlin, John R, Merletti, Franco, Migliore, Enrica, Richiardi, Lorenzo, Pándics, Tamás, Pohlabeln, Hermann, Siemiatycki, Jack, Świątkowska, Beata, Wichmann, Heinz-Erich, Zaridze, David, Ge, Calvin, Straif, Kurt, Kromhout, Hans, and Vermeulen, Roel

Published
2024

9. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships

Author

IRAS OH Epidemiology Chemical Agents, Institute for Risk Assesment Sciences, IRAS – One Health Chemical, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, Peters, Susan, IRAS OH Epidemiology Chemical Agents, Institute for Risk Assesment Sciences, IRAS – One Health Chemical, Ohlander, Johan, Kromhout, Hans, Vermeulen, Roel, Portengen, Lützen, Kendzia, Benjamin, Savary, Barbara, Cavallo, Domenico, Cattaneo, Andrea, Migliori, Enrica, Richiardi, Lorenzo, Plato, Nils, Wichmann, Heinz-Erich, Karrasch, Stefan, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Siemiatycki, Jack, Gustavsson, Per, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Fernández-Tardón, Guillermo, Zaridze, David, Jolanta Lissowska, Jolanta Lissowska, Beata Swiatkowska, Beata Swiatkowska, John K Field, John K Field, McLaughlin, John R, Demers, Paul A, Pandics, Tamas, Forastiere, Francesco, Fabianova, Eleonora, Schejbalova, Miriam, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Barul, Christine, Brüning, Thomas, Behrens, Thomas, Straif, Kurt, Schüz, Joachim, Olsson, Ann, and Peters, Susan

Published
2024

13. Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure–response relationships

Author

Ohlander, Johan, primary, Kromhout, Hans, additional, Vermeulen, Roel, additional, Portengen, Lützen, additional, Kendzia, Benjamin, additional, Savary, Barbara, additional, Cavallo, Domenico, additional, Cattaneo, Andrea, additional, Migliori, Enrica, additional, Richiardi, Lorenzo, additional, Plato, Nils, additional, Wichmann, Heinz-Erich, additional, Karrasch, Stefan, additional, Consonni, Dario, additional, Landi, Maria Teresa, additional, Caporaso, Neil E, additional, Siemiatycki, Jack, additional, Gustavsson, Per, additional, Jöckel, Karl-Heinz, additional, Ahrens, Wolfgang, additional, Pohlabeln, Hermann, additional, Fernández-Tardón, Guillermo, additional, Zaridze, David, additional, Jolanta Lissowska, Jolanta Lissowska, additional, Beata Swiatkowska, Beata Swiatkowska, additional, John K Field, John K Field, additional, McLaughlin, John R, additional, Demers, Paul A, additional, Pandics, Tamas, additional, Forastiere, Francesco, additional, Fabianova, Eleonora, additional, Schejbalova, Miriam, additional, Foretova, Lenka, additional, Janout, Vladimir, additional, Mates, Dana, additional, Barul, Christine, additional, Brüning, Thomas, additional, Behrens, Thomas, additional, Straif, Kurt, additional, Schüz, Joachim, additional, Olsson, Ann, additional, and Peters, Susan, additional

Published
2024
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15. Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies

Author

Wan, Wenxin, primary, Peters, Susan, additional, Portengen, Lützen, additional, Olsson, Ann, additional, Schüz, Joachim, additional, Ahrens, Wolfgang, additional, Schejbalova, Miriam, additional, Boffetta, Paolo, additional, Behrens, Thomas, additional, Brüning, Thomas, additional, Kendzia, Benjamin, additional, Consonni, Dario, additional, Demers, Paul A, additional, Fabiánová, Eleonóra, additional, Fernández-Tardón, Guillermo, additional, Field, John K., additional, Forastiere, Francesco, additional, Foretova, Lenka, additional, Guénel, Pascal, additional, Gustavsson, Per, additional, Jöckel, Karl-Heinz, additional, Karrasch, Stefan, additional, Landi, Maria Teresa, additional, Lissowska, Jolanta, additional, Barul, Christine, additional, Mates, Dana, additional, McLaughlin, John R., additional, Merletti, Franco, additional, Migliore, Enrica, additional, Richiardi, Lorenzo, additional, Pándics, Tamás, additional, Pohlabeln, Hermann, additional, Siemiatycki, Jack, additional, Świątkowska, Beata, additional, Wichmann, Heinz-Erich, additional, Zaridze, David, additional, Ge, Calvin, additional, Straif, Kurt, additional, Kromhout, Hans, additional, and Vermeulen, Roel, additional

Published
2023
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29. Additional file 1: of Head and neck cancer and occupational exposure to leather dust: results from the ICARE study, a French case-control study

Author

Radoï, Loredana, Fatoumata Sylla, Matrat, Mireille, Barul, Christine, Menvielle, Gwenn, Delafosse, Patricia, Stßcker, Isabelle, and DanièLe Luce

Subjects
technology, industry, and agriculture, otorhinolaryngologic diseases, complex mixtures
Abstract

Table S1. Formula and weight for calculating the cumulative exposure index (CEI) to leather dust. Table S2. Odds ratios for head and neck cancer associated with occupational exposure to leather dust, stratified by sex. Table S3. Odds ratios for head and neck cancer associated with occupational exposure to leather dust, stratified by tobacco smoking status. Table S4. Odds ratios for head and neck cancer associated with occupational exposure to leather dust, stratified by alcohol drinking status. (DOCX 60 kb)

Published
2019
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30. Welding and the risk of head and neck cancer: the ICARE study

Author

Barul, Christine, primary, Matrat, Mireille, additional, Auguste, Aviane, additional, Dugas, Julien, additional, Radoï, Loredana, additional, Menvielle, Gwenn, additional, Févotte, Joëlle, additional, Guizard, Anne-Valérie, additional, Stücker, Isabelle, additional, and Luce, Danièle, additional

Published
2020
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32. Additional file 2: of Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

Author

Barul, Christine, Carton, Matthieu, Radoï, Loredana, Menvielle, Gwenn, Pilorget, Corinne, Bara, Simona, Stßcker, Isabelle, and DanièLe Luce

Subjects
body regions, nervous system, fungi, complex mixtures
Abstract

Spearman correlation coefficients between cumulative exposures to petroleum-based and oxygenated solvents. (PDF 193 kb)

Published
2018
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34. Additional file 4: of Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

Author

Barul, Christine, Carton, Matthieu, Radoï, Loredana, Menvielle, Gwenn, Pilorget, Corinne, Bara, Simona, Stßcker, Isabelle, and DanièLe Luce

Subjects
body regions, nervous system, fungi
Abstract

Association between hypopharyngeal and laryngeal cancers and exposure to oxygenated solvents, with adjustment for socioeconomic status. (PDF 116 kb)

Published
2018
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35. Additional file 3: of Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

Author

Barul, Christine, Carton, Matthieu, Radoï, Loredana, Menvielle, Gwenn, Pilorget, Corinne, Bara, Simona, Stßcker, Isabelle, and DanièLe Luce

Subjects
body regions, nervous system, fungi, complex mixtures
Abstract

Association between hypopharyngeal and laryngeal cancers and exposure to petroleum-based solvents, with adjustment for socioeconomic status. (PDF 115 kb)

Published
2018
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36. Occupational Exposure to Solvants and Risk of Head and Neck Cancer

Author

Barul, Christine, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Paris Saclay (COmUE), Danièle Luce, STAR, ABES, and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Cancer des voies aéro-Digestives supérieures, Occupational exposures, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cavité buccale, Solvants, Solvents, Pharynx, [SDV.CAN]Life Sciences [q-bio]/Cancer, Larynx, Head and neck cancer, Expositions professionelles, Oral cavity
Abstract

Background : The role of occupational exposure to solvents in the risk of head and neck cancer has been suggested in some studies but has been few investigated, despite their widespread use in the workplace. Objective: The objective of this thesis was to examine the associations between occupational exposure to solvents and the risk of head and neck cancer. Methods: This work is based on data from the ICARE study, a large population-based case-control study conducted in France between 2001 and 2007. The analysis was restricted to men and included 1,857 cases of squamous cell carcinoma of the oral cavity, pharynx and larynx and 2,780 controls. Detailed occupational lifetime as well as alcohol and tobacco consumptions were collected by questionnaires. Exposure to solvents was assessed by job exposure matrices and included five chlorinated solvents (perchloroethylene, trichloroethylene, methylene chloride, chloroform, carbon tetrachloride), five petroleum-based solvents (benzene; gasoline; diesel, fuels and kerosene; special petroleum products; white spirits) and five oxygenated solvents (ketones and esters; alcohols; diethyl ether; ethylene glycol; tetrahydrofuran). Odds-ratios adjusted for smoking, alcohol drinking and other potential confounders and 95% confidence intervals were estimated with logistic models. Results: No significant association was found between occupational exposure to chlorinated, petroleum-based and oxygenated solvents and the risk of head and neck cancer overall. In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to perchloroethylene. Non-significantly elevated risks of hypopharyngeal cancer were found in men exposed to high cumulative levels of methylene chloride, white spirits and tetrahydrofuran. An association between exposure to tetrahydrofuran and oral cavity cancer was also suggested. No other clear association was found for the other solvents under study, for any cancer site. Conclusion: Although positive associations were observed for several solvents, overall the results do not suggest a substantial role of exposure to solvents in head and neck cancer risk., Contexte : Le rôle de l’exposition professionnelle aux solvants dans la survenue de cancers des voies aéro-digestives supérieures (VADS), suggéré dans quelques études, n’a été que peu examiné, malgré leur utilisation très répandue en milieu de travail. Objectif : L’objectif de cette thèse état d’évaluer les associations entre les expositions professionnelles aux solvants et le risque de cancer des VADS. Méthodes : Ce travail est basé sur les données de l’étude Icare, une large étude cas-témoins en population générale conduite en France entre 2001-2007. L’analyse a été restreinte aux hommes et a porté sur 1857 cas de carcinome épidermoïde de la cavité buccale, du pharynx et du larynx, et 2780 témoins. L’histoire professionnelle détaillée ainsi que les consommations de tabac et d’alcool ont été recueillies par questionnaire. Les expositions aux solvants ont été évaluées à l’aide de matrices emplois-expositions et incluaient cinq solvants chlorés (perchloroéthylène, trichloroéthylène, chlorure de méthylène, chloroforme, tétrachlorure de carbone), cinq solvants pétroliers (benzène ; essences carburant ; gazole, fiouls et kérosène ; essences spéciales ; white spirits) et cinq solvants oxygénés (cétones et esters ; alcools ; éther éthylique ; éthylène glycol ; tétrahydrofurane). Les odds-ratios ajustés sur les consommations de tabac et d’alcool et d’autres facteurs de confusion potentiels, et les intervalles de confiances à 95% ont été estimés par régression logistique. Résultats : Aucune association significative n’a été mise en évidence entre exposition professionnelle aux solvants chlorés, pétroliers et oxygénés étudiés et le risque de cancer de l’ensemble des VADS. Dans l’analyse par localisation, le risque de cancer du larynx augmentait significativement avec l’exposition cumulée au perchloroéthylène. Des risques élevés de cancer de l’hypopharynx, bien que non significatifs, étaient observés pour les hommes exposés à des niveaux élevés de chlorure de méthylène, de white spirits et de tétrahydrofurane. Une association entre exposition au tétrahydrofurane et cancer de la cavité buccale était également suggérée. Aucune association claire n’était observée pour les autres solvants, quelle que soit la localisation de cancer. Conclusion : Des associations positives ont été observées avec plusieurs solvants spécifiques. Toutefois, dans l’ensemble, nos résultats ne sont pas en faveur d’un rôle majeur de l’exposition aux solvants dans la survenue de cancer des VADS.

Published
2017

37. Exposition professionnelle aux solvants et risque de cancer des voies aéro-digestives supérieures

Author

Barul, Christine, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Paris Saclay (COmUE), Danièle Luce, and STAR, ABES

Subjects
Cancer des voies aéro-Digestives supérieures, Occupational exposures, [SDV.CAN] Life Sciences [q-bio]/Cancer, Solvants, Cavité buccale, Solvents, Pharynx, [SDV.CAN]Life Sciences [q-bio]/Cancer, Larynx, Head and neck cancer, Expositions professionelles, Oral cavity
Abstract

Background : The role of occupational exposure to solvents in the risk of head and neck cancer has been suggested in some studies but has been few investigated, despite their widespread use in the workplace. Objective: The objective of this thesis was to examine the associations between occupational exposure to solvents and the risk of head and neck cancer. Methods: This work is based on data from the ICARE study, a large population-based case-control study conducted in France between 2001 and 2007. The analysis was restricted to men and included 1,857 cases of squamous cell carcinoma of the oral cavity, pharynx and larynx and 2,780 controls. Detailed occupational lifetime as well as alcohol and tobacco consumptions were collected by questionnaires. Exposure to solvents was assessed by job exposure matrices and included five chlorinated solvents (perchloroethylene, trichloroethylene, methylene chloride, chloroform, carbon tetrachloride), five petroleum-based solvents (benzene; gasoline; diesel, fuels and kerosene; special petroleum products; white spirits) and five oxygenated solvents (ketones and esters; alcohols; diethyl ether; ethylene glycol; tetrahydrofuran). Odds-ratios adjusted for smoking, alcohol drinking and other potential confounders and 95% confidence intervals were estimated with logistic models. Results: No significant association was found between occupational exposure to chlorinated, petroleum-based and oxygenated solvents and the risk of head and neck cancer overall. In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to perchloroethylene. Non-significantly elevated risks of hypopharyngeal cancer were found in men exposed to high cumulative levels of methylene chloride, white spirits and tetrahydrofuran. An association between exposure to tetrahydrofuran and oral cavity cancer was also suggested. No other clear association was found for the other solvents under study, for any cancer site. Conclusion: Although positive associations were observed for several solvents, overall the results do not suggest a substantial role of exposure to solvents in head and neck cancer risk., Contexte : Le rôle de l’exposition professionnelle aux solvants dans la survenue de cancers des voies aéro-digestives supérieures (VADS), suggéré dans quelques études, n’a été que peu examiné, malgré leur utilisation très répandue en milieu de travail. Objectif : L’objectif de cette thèse état d’évaluer les associations entre les expositions professionnelles aux solvants et le risque de cancer des VADS. Méthodes : Ce travail est basé sur les données de l’étude Icare, une large étude cas-témoins en population générale conduite en France entre 2001-2007. L’analyse a été restreinte aux hommes et a porté sur 1857 cas de carcinome épidermoïde de la cavité buccale, du pharynx et du larynx, et 2780 témoins. L’histoire professionnelle détaillée ainsi que les consommations de tabac et d’alcool ont été recueillies par questionnaire. Les expositions aux solvants ont été évaluées à l’aide de matrices emplois-expositions et incluaient cinq solvants chlorés (perchloroéthylène, trichloroéthylène, chlorure de méthylène, chloroforme, tétrachlorure de carbone), cinq solvants pétroliers (benzène ; essences carburant ; gazole, fiouls et kérosène ; essences spéciales ; white spirits) et cinq solvants oxygénés (cétones et esters ; alcools ; éther éthylique ; éthylène glycol ; tétrahydrofurane). Les odds-ratios ajustés sur les consommations de tabac et d’alcool et d’autres facteurs de confusion potentiels, et les intervalles de confiances à 95% ont été estimés par régression logistique. Résultats : Aucune association significative n’a été mise en évidence entre exposition professionnelle aux solvants chlorés, pétroliers et oxygénés étudiés et le risque de cancer de l’ensemble des VADS. Dans l’analyse par localisation, le risque de cancer du larynx augmentait significativement avec l’exposition cumulée au perchloroéthylène. Des risques élevés de cancer de l’hypopharynx, bien que non significatifs, étaient observés pour les hommes exposés à des niveaux élevés de chlorure de méthylène, de white spirits et de tétrahydrofurane. Une association entre exposition au tétrahydrofurane et cancer de la cavité buccale était également suggérée. Aucune association claire n’était observée pour les autres solvants, quelle que soit la localisation de cancer. Conclusion : Des associations positives ont été observées avec plusieurs solvants spécifiques. Toutefois, dans l’ensemble, nos résultats ne sont pas en faveur d’un rôle majeur de l’exposition aux solvants dans la survenue de cancer des VADS.

Published
2017

38. Additional file 1: Figure S1. of Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France

Author

Barul, Christine, Fayossé, Aurore, Carton, Matthieu, Pilorget, Corinne, Anne-Sophie Woronoff, Stücker, Isabelle, and Luce, Danièle

Subjects
polycyclic compounds
Abstract

Image plot for Spearman’s correlations coefficient among chlorinated solvents and asbestos’ CEI. Table S1. Associations between exposure to chlorinated solvents and head and neck cancer, without adjustment for asbestos exposure. Table S2. Association between head and neck cancer and exposure to chlorinated solvents, with adjustment for educational level. Table S3. Association between head and neck cancer and exposure to chlorinated solvents, with adjustment for occupational class. (PDF 263 KB)

Published
2017
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41. Mediterranean diet and preserved brain structural connectivity in older subjects

Author

Samieri, Cecilia, Pelletier, Amandine, Barul, Christine, Feart, Catherine, Helmer, Catherine, Bernard, Charlotte, Dartigues, Jean-Francois, Allard, Michele, Barberger-Gateau, Pascale, Catheline, Gwenaelle, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), CHU Bordeaux [Bordeaux], Epidemiologie-Biostatistique [Bordeaux], and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux Ségalen [Bordeaux 2]

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

44. P1-262: The mediterranean diet and preservation of brain connectivity in older subjects

Author

Samieri, Cécilia, primary, Pelletier, Amandine, additional, Barul, Christine, additional, Féart, Catherine, additional, Helmer, Catherine, additional, Bernard, Charlotte, additional, Périot, Olivier, additional, Dilharreguy, Bixente, additional, Dartigues, Jean-François, additional, Allard, Michèle, additional, Barberger-Gateau, Pascale, additional, and Catheline, Gwenaëlle, additional

Published
2015
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45. Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France.

Author

Barul, Christine, Fayossé, Aurore, Carton, Matthieu, Pilorget, Corinne, Woronoff, Anne-Sophie, Stücker, Isabelle, Luce, Danièle, and ICARE study group

Subjects
*INDUSTRIAL toxicology, *CHLORINE compounds, *SOLVENTS, *SOLUTION (Chemistry), *CANCER in men, *HEAD tumors, *HYDROCARBONS, *NECK tumors, *OCCUPATIONAL diseases, *OCCUPATIONAL hazards, *ENVIRONMENTAL exposure, *DISEASE prevalence, *CASE-control method
Abstract

Background: Few epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk.Methods: We analyzed data from 4637 men (1857 cases and 2780 controls) included in a population-based case-control study, ICARE (France). Occupational exposure to five chlorinated solvents (perchloroethylene [PCE], trichloroethylene [TCE], methylene chloride [MC], chloroform [CF], and carbon tetrachloride [CT]) was assessed through job-exposure matrices. Odds ratios (ORs) and confidence intervals (95% CI) were estimated by unconditional logistic regression, adjusted for age, tobacco smoking, alcohol consumption, asbestos exposure, and other potential confounders.Results: We observed no association between chlorinated solvent exposure and head and neck cancer risk, despite a non-significant increase in risk among subjects who had the highest cumulative level of exposure to PCE, (OR = 1.81; 95% CI = 0.68 to 4.82). In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to PCE (p for trend = 0.04). The OR was 3.86 (95% CI = 1.30 to 11.48) for those exposed to the highest levels of PCE. A non-significant elevated risk of hypopharyngeal cancer was also observed in subjects exposed to the highest levels of MC (OR = 2.36; 95% CI = 0.98 to 5.85).Conclusion: Our findings provide evidence that high exposure to PCE increases the risk of laryngeal cancer, and suggest an association between exposure to MC and hypopharyngeal cancer. Exposure to other chlorinated solvents was not associated with the risk of head and neck cancer. [ABSTRACT FROM AUTHOR]

Published
2017
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47. Coffee and tea consumption and the risk of head and neck cancer: An updated pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Author

Nguyen, Timothy, Koric, Alzina, Chang, Chun‐Pin Esther, Barul, Christine, Radoi, Loredana, Serraino, Diego, Purdue, Mark P., Kelsey, Karl T., McClean, Michael D., Negri, Eva, Edefonti, Valeria, Moysich, Kirsten, Zhang, Zuo‐Feng, Morgenstern, Hal, Levi, Fabio, Vaughan, Thomas L., La Vecchia, Carlo, Garavello, Werner, Hayes, Richard B., and Benhamou, Simone

Subjects
*HEAD & neck cancer, *HYPOPHARYNGEAL cancer, *LARYNGEAL cancer, *COFFEE drinks, *EPIDEMIOLOGY of cancer
Abstract

Introduction Methods Results Conclusion The relations between coffee and tea consumption and head and neck cancer (HNC) incidence are unclear. With increasing global HNC burden, this study aims to examine the association between coffee, tea, and HNC.A pooled analysis of 9548 HNC cases and 15,783 controls from 14 individual‐level case‐control studies was conducted from the International Head and Neck Cancer Epidemiology consortium. Random‐effects logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for HNC and its subsites, adjusting for sociodemographic and lifestyle factors.Compared to non–coffee drinkers, drinking >4 cups of caffeinated coffee daily was inversely associated with HNC (OR, 0.83; 95% CI, 0.69–1.00), oral cavity (OR, 0.70; 95% CI, 0.55–0.89), and oropharyngeal cancers (OR, 0.78; 95% CI, 0.61‐0.99). Drinking 3–4 cups of caffeinated coffee was inversely associated with hypopharyngeal cancer (OR, 0.59; 95% CI, 0.39–0.91). Drinking decaffeinated coffee and drinking between >0 to <1 cup daily were inversely associated with oral cavity cancer (OR, 0.75; 95% CI, 0.64–0.87 and OR, 0.66; 95% CI, 0.54–0.81). Drinking tea was inversely associated with hypopharyngeal cancer (OR, 0.71; 95% CI, 0.59–0.87). Daily tea consumption of >0 to ≤1 cup was inversely associated with HNC (OR, 0.91; 95% CI, 0.84–0.98) and hypopharyngeal cancer (OR, 0.73; 95% CI, 0.59–0.91), but drinking >1 cup was associated with laryngeal cancer (OR, 1.38; 95% CI, 1.09–1.74).These findings support reduced HNC risk among coffee and tea drinkers. Future studies are needed to address geographical differences in types of coffee and tea to improve our understanding of the association of coffee and tea and global HNC risk. [ABSTRACT FROM AUTHOR]

Published
2024
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