Search

A triangular prism cage 2 with benzene triimide (BTI) as the base and 2,7-naphthalene dimethylene as the supporting pillars was designed and synthesized efficiently. The two parallel BTI planes con...

Asphalt emulsion is a common material used for pavement base course stabilization, and cement is usually added as an active filler to improve the stability of asphalt emulsion mixtures further. However, using cement in these mixes has several drawbacks, including high material costs and environmental issues. On the other hand, asphaltenes is a waste by-product derived from the processing of Alberta oil-sands bitumen that could be used for the same purpose. This investigation compares the impact of cement and asphaltenes as additives to asphalt emulsion-stabilized layers. To compare the performance properties, cement- and asphaltenes-modified mixtures are prepared at different concentrations. The performance properties of the modified mixtures are investigated by conducting a series of tests including Marshall stability, indirect tensile strength, IDEAL-CT, and tensile strength ratio. In addition, to evaluate low-temperature cracking resistance of the mixtures, indirect tensile strength test is conducted at 0 °C and –10 °C.

Summary The integration of the growth of the brain and the cranial base suggests that each system may influence the other, notably during the first three years of life, although this influence has never been proven to be exclusive. The aim of our work was to analyse the dynamics of normal growth on the one hand, and the development and ontogenetic allometry of the cranial base in the infant on the other hand. Material and method A total of 32 infants (17 males/15 femeles) having been included in the unexpected infant death french protocol were analyzed. Three-dimensional reconstructions of the cranial base were performed from CT scans. The technique combined manual segmentation of regions of interest, contour extraction and surface reconstruction. Nineteen landmarks were positioned on each of the bone surfaces. Results No correlation was observed between sex assigned at birth and shape, weight, crown-heel length, or head circumference. Principal component analysis showed that 85.5% of the variance observed on the first component was secondary to growth. After Procrustes superimposition, 25% of the shape variance observed was explained by the first principal component. It showed anteroposterior lengthening of the cranial base. In addition, the height, width and length of the posterior fossa increased and the relative position of the basion was displaced inferiorly and anteriorly with flexion of the sphenoid angle. Negative allometry was also observed. Conclusion Our study, carried out in a rigorously selected population of infants, presents a fundamental approach to ontogeny through study of shape, growth and ontogenetic allometry.

BACKGROUNDPatients undergoing emergency high-risk abdominal surgery potentially suffer from both systemic dehydration and hypovolaemia. Data on the prevalence and clinical impact of electrolyte disturbances in this patient group, specifically the potential differences in patients with intestinal obstruction (IO) versus perforated viscus (PV) is lacking. METHODSIn this retrospective single center cohort study, adult patients undergoing emergency high-risk abdominal surgery in a standardized perioperative pathway were included. Electrolyte and arterial blood gas analysis were measured prior to and just after surgery. Prevalence and clinical impact of electrolyte disturbances were assessed. RESULTSA total of 354 patients were included in the study. Acid-base and electrolyte disturbances had a high incidence in both groups with preoperative alkalemia dominating preoperatively, significantly more prevalent in IO (45 vs.32%, pp= 0.006 and OR 6.86 (1.71, 32.2) p= 0.009 respectively. Hypochloremic patients presented with reduced long-term survival as compared with the normo- and hyperchloremic patients, with postoperative hypochloremia having the most pronounced association (p

A series of novel amide and Schiffs base functionalized novel pyrido[1,2-a] pyrimidin- 4-one derivatives was prepared starting from 6-(thiophen-2-yl)/phenyl-4-(trifluoromethyl) pyridin- 2-amine 1a and 1b. These compounds on reacting with EMME afford compounds 2a and 2b, followed by cyclization to afford compounds 3a and 3b. Treatment of compounds 3a and 3b with hydrazine hydrate gave compounds 4a and 4b, which further reacted with different substituted aromatic aldehydes to give Schiff’s base derivatives 5a-j. In another way, compounds 3a, 3b by reacting with aliphatic amines give amide derivatives 6a-f. All the compounds, 5a-j and 6a-f, were screened against four human cancer cell lines (HeLa, COLO205, Hep G2, and MCF 7). Among all the derivatives, compounds 5c, 5e, 6a, and 6b showed promising anticancer activity.

Human pluripotent stem cells (hPSCs) have great potential for disease modeling, drug discovery, and regenerative medicine as they can differentiate into many different functional cell types via directed differentiation. However, the application of disease modeling is limited due to a time-consuming and labor-intensive process of introducing known pathogenic mutations into hPSCs. Base editing is a newly developed technology that enables the facile introduction of point mutations into specific loci within the genome of living cells without unwanted genome injured. We describe an optimized stepwise protocol to introduce disease-specific mutations of long QT syndrome (LQTs) into hPSCs. We highlight technical issues, especially those associated with introducing a point mutation to obtain isogenic hPSCs without inserting any resistance cassette and reproducible cardiomyocyte differentiation. Based on the protocol, we succeeded in getting hPSCs carrying LQTs pathogenic mutation with excellent efficiency (31.7% of heterozygous clones, 9.1% of homozygous clones) in less than 20 days. In addition, we also provide protocols to analyze electrophysiological of hPSC-derived cardiomyocytes using multi-electrode arrays. This protocol is also applicable to introduce other disease-specific mutations into hPSCs. Graphical abstract

Backgroundː Endodontic Sealers come in direct contact with periapical tissue through the apical foramen and lateral canals, influencing the postoperative pain and periapical healing. The aim of the present study was to evaluate and compare postoperative pain and periapical healing after root canal treatment using different base endodontic sealers.Methodsː Primary root canal treatment was initiated in 63 patients diagnosed with necrotic pulp and apical periodontitis, followed by which the endodontic sealers used for obturation were selected based on the random allocation of the participants to the following groups; Tubli-Seal, AH Plus and BioRoot RCS. Postoperative pain was recorded by using 100 mm visual analog scale at 24 h, 48 h, 72 h and 7 d after obturation. Digital periapical radiographic evaluation was done to assess rate of periapical healing at baseline, 1, 3 and 6 months. Statistical analysis was done using Kruskal Wallis test and one-way ANOVA and p-value of less than 0.05 was considered as significance level.Resultsː Significant reduction was seen in the size of periapical lesions in all the study groups at 3 and 6 months (p ˂ 0.05). The mean difference in the size of periapical lesions for BioRoot RCS was 4.05, 10.22, for AH Plus was 2 3.86, 9.80 and Tubli-Seal were 6.27, 13.41 at 3 months and 6 months respectively. The mean pain scores at 24 h for Tubli-Seal, AH Plus, BioRoot RCS were 17.94 ± 11.35, 11.57 ± 11.18 and 4.73 ± 7.72. At 48 h were 5.26 ± 9.04, 1.57 ± 3.74 and 1.57 ± 3.74 respectively. The mean pain score at 72 h for Tubli-Seal was 2.63 ± 7.33 whereas none of the patients had reported pain in AH Plus and BioRoot RCS group. None of the patients had pain 7 d after treatment.Conclusionsː BioRoot RCS showed less postoperative pain compared to AH Plus and Tubli-Seal. BioRoot RCS showed better periapical healing compared to AH Plus and Tubliseal at 3- and 6-months interval respectively.Trial Registration: Registration of this trial was done prospectively in Clinical trials registry – India (CTRI) with registration number (CTRI/2018/10/015919) dated 08/10/2018.

The method of stump closure is controversial in complicated patients, especially with appendix base necrosis or perforation.To evaluate the efficacy and safety of partial cecum resection technique with an endostapler in patients with appendix base necrosis or perforation.Thirty-six patients who underwent laparoscopic partial cecum resection due to appendix base necrosis or perforation between 2015 and 2020 were retrospectively analyzed. In acute complicated appendicitis with appendiceal base necrosis or perforation, it was performed by laparoscopic partial cecum resection using an endostapler within a safe surgical margin. Demographic characteristics, duration of operation, days of hospital stay, and intra- and post-operative complications were evaluated.The mean age of the patients is 42.72 ±16.69, female/male ratio was 19/17 (52.8%/47.2%). No intraoperative complications developed. Mean operative time and hospital stay were 104.75 ±34.96, 4.58 ±2.82 days, respectively. Post-operative complications developed in 5 (13.7%) patients. One of them was wound infection (2.7%), 2 of them were ileus (5.5%) and 2 patients had an intraabdominal abscess (5.5%). Stapler line leak was not observed in any of the patients.The use of an endostapler in laparoscopic appendectomy is a safe and effective technique in cases where appendix base necrosis, appendix perforation or severe inflammation affects the base of the cecum.

Zn(OAc)2•2H2O-catalyzed one-pot multicomponent reaction of Betti bases using β- naphthol, aldehydes, and amines, under neat conditions in moderate to excellent yields (68- 96%) is reported in this study. This synthetic protocol offers several advantages, such as operational simplicity, shorter reaction period, high yields, and easy work-up procedures.

Previous studies in the field of acid-base and oxidative status in cows have mainly focused on the transition period (three weeks before and three weeks after calving). The aim of this study was to determine the differences in the parameters of acid- base and oxidative status and electrolyte balance in cows not only during the transition period, but also at other stages of the production cycle. Holstein-Friesian cows were divided into four numerically equal groups (n = 6): early lactating cows (9±2 days in milk - DIM), peak lactating cows (50±5 DIM), late lactating cows (170±10 DIM) and dry cows (10±1 days before calving). Venous blood samples were taken from the cows to analyze acid-base status, electrolyte concentrations and oxidative stress parameters, and to compare group means. Significantly higher pH was observed in early lactating cows than in late lactating cows. Sodium (Na+) concentration was significantly lower in early lactating and peak lactating cows compared to dry cows, while chloride (Cl-) concentration was also lower in late lactating cows compared to dry cows. Plasma glutathione peroxidase (GSH-Px) activity was higher in early lactating cows compared to peak lactating cows. Thus, the highest blood pH, lowest Na+ and Cl- concentrations and highest serum GSH-Px activity were observed in early lactating cows compared to other groups, indicating the highest metabolic and oxidative stress during this period. In conclusion, it would be useful to consider the inclusion of these parameters in standard health assessment procedures in intensive dairy production. Prethodna istraživanja na polju acidobaznog i oksidativnog statusa krava uglavnom su bila usredsređena na tranzicioni period (tri nedelje pre i tri nedelje nakon teljenja). Cilj ovog istraživanja bio je da se utvrde razlike u parametrima acidobaznog i oksidativnog statusa, kao i u balansu elektrolita, ne samo u tranzicionom periodu, nego i u ostalim fazama proizvodnog ciklusa krava. Krave holštajn-frizijske rase podeljene su u četiri jednake grupe (n=6): krave u ranoj laktaciji (9±2 dana laktacije – DL), krave u piku laktacije (50±5 DL), krave u kasnoj laktaciji (170±10 DL) i krave u zasušenju (10±1 dana pre očekivanog teljenja). Od ispitivanih krava prikupljeni su uzorci venske krvi za analizu acidobaznog i oksidativnog statusa i koncentraciju elektrolita. U ovom istraživanju zabeležena je značajno viša pH vrednost krvi kod krava u ranoj laktaciji nego kod krava u zasušenju. Koncentracija natrijuma (Na+) bila je značajno niža kod krava u ranoj laktaciji i piku laktacije u poređenju sa kravama u zasušenju, dok je koncentracija hlora (Cl- ) bila značajno niža i kod krava u kasnoj laktaciji u poređenju sa kravama u zasušenju. Aktivnost glutation peroksidaze (GSH-Px) bila je značajno viša kod krava u ranoj laktaciji u poređenju sa kravama u piku laktacije. Najviše pH vrednosti krvi, najniža koncentracija Na+ i Cl- i najviša aktivnost GSH-Px zabeleženi su kod krava u ranoj laktaciji, što ukazuje na najveći metabolički i oksidativni stres tokom ovog perioda. Imajući u vidu dobijene razlike bilo bi značajno razmotriti uvođenje parametara ispitivanih u ovom radu u standardne procedure za procenu zdravlja krava u intenzivnoj proizvodnji mleka.

Background:. Anogenital distance (AGD) in both humans and animals is a known reflection of fetal endocrine effect on genital virilization and the related abnormalities, including cryptorchidism and hypospadias. However, we introduce here and investigate scrotal base distance (SBD) as a sensitive genital anthropometric biomarker in human infants with cryptorchidism and hypospadias, which are considered early manifestations of testicular dysgenesis syndrome. We aim to assess SBD in patients with cryptorchidism or hypospadias against healthy subjects. Material and methods:. Patients with hypospadias (n = 61, age 17.4 ± 6.3 months) or cryptorchidism (n = 51, age 11.4 ± 4.8 months) were enrolled for assessment of SBD, AGD, and penile length; and compared with a cohort of 102 full-term healthy boys for standard ritual circumcision by measuring age-specific standard deviation scores. Results:. Patients having hypospadias had lower mean SBD, AGD, and penile length standard deviation scores than the control group (p

Application of base isolators undermines the drawback of earthquake to the structures. In recent decades, various base isolators have been applied, and several researchers have conducted research on the influence of base isolated structures. In this study, a rubber bearing with steel rings called RRB is designed and applied in 3 to 6- story steel and concrete structures, and the results are compared to fixed base and isolated base structures with lead rubber bearing (LRB). Isolators are first modeled in finite element software Abaqus, and hysteresis analysis is done, and effective stiffness and damping of each isolator is obtained. The average results for effective stiffness of the LRB is 110.88 (ton/m) and for the RRB is 82.48 (ton/m). The average damping for the LRB is 18.44%, and for the RRB is 47.02%. The analysis of structures is considered nonlinear time history and is done with the earthquake records of Kobe, Tabas and Manjil. The results of drift, acceleration and base shear are presented. The acceleration results of RRB isolated base structure show that 3, 4, 5 and 6-story buildings has a reduction by 42.16, 43.36, 51.83 and 57.16%. Moreover, the shear results of RRB isolated base structures comparing to the corresponding fixed base structure has had a reduction of 55.5, 47.16, 37.93 and 56.83 for 3, 4, 5 and 6-story structures. The results for drift indicate that utilization of the RRB leads to a decrease by 35.33, 50, 54.5% and 59.66 for 3, 4, 5 and 6-story structures, respectively.

Purpose To investigate the oncological outcomes of orbital malignant tumors invading the skull base. Methods A retrospective analysis was conducted on 16 patients with orbital malignant tumors invading the skull base. Eleven patients were treated with skull base surgery, four patients were treated with particle therapies, and one patient was treated with chemoradiotherapy (CRT) as initial treatment. Results The most frequent histological type was adenoid cystic carcinoma in seven patients, followed by squamous cell carcinoma in two patients. Local recurrence occurred in two of the six surgically treated patients who did not receive postoperative radiotherapy (RT) or CRT. One of them was successfully salvaged by RT, and the other died of disease. With a median follow‐up of 24 months, the 2‐year overall, local control, and disease‐free survival rates of all patients were 82.5%, 87.5%, and 59%, respectively. Conclusions Patients with positive surgical margins were at risk of local recurrence. Postoperative RT should be considered for all surgically treated patients. Level of Evidence: 4.

Purpose: Improvement of the differential diagnosis of fibrous dysplasia of the of the base of the skull on the basis of X-ray computed tomography data, taking into account clinical and medical data.Material and methods: The results of examination of 24 patients with lesions of the base of the skull were analyzed. Group 1: 15 patients with fibrous dysplasia, directed to examination with a diagnosis of osteoplastic metastases of the base of the skull. Group 2: 9 patients with metastases to the base of the skull. All patients underwent computer tomography and SPECT/CT.Results: Comparison of clinical and radiological symptoms in patients with metastatic lesions of the base of the skull (group 2) and patients with fibrous dysplasia of the base of the skull (group 1) allows us to state that errors in the differential diagnosis of bone metastases and fibrous dysplasia of the base of the skull in a number of cases are associated with a lack of awareness of radiologists.Conclusion: The presented data will help to improve the diagnosis of fibrous dysplasia of the base of the skull.

In this study, the use of shear strength ratio (SSR) in analysing asphalt mixture’s susceptibility to moisture was investigated and verified. Three surface and two base mixtures were considered for...

Industrial waste is produced in large amounts annually; without proper planning, the waste might cause a serious threat to the environment. Hence, an industrial waste-based heterogeneous magnetic catalyst was synthesized using carbide lime waste (CLW) as raw material for biodiesel production via transesterification of palm oil. The catalyst was successfully synthesized by the one-step impregnation method and calcination at 600 °C. The synthesized catalyst, C-CLW/g-Fe2O3, was characterized by temperature-programmed desorption of carbon dioxide (CO2-TPD), scanning electron microscopy (SEM), electron dispersive X-ray spectroscopy (EDX), X-ray Diffraction (XRD), Brunauer-Emmett-Teller (BET), vibrating sample magnetometer (VSM), and Fourier transform infrared spectroscopy (FT-IR). The catalyst has a specific surface area of 18.54 m2/g and high basicity of 3,637.20 µmol/g. The catalytic performance shows that the optimum reaction conditions are 6 wt% catalyst loading, 12:1 methanol to oil molar ratio with the reaction time of 3 h at 60 °C to produce 90.5% biodiesel yield. The catalyst exhibits good catalytic activity and magnetism, indicating that the CLW can be a potential raw material for catalyst preparation and application in the biodiesel industry. Copyright © 2021 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).

Brick masonry does not exhibit much capacity to resist lateral loads and hence the masonry suffers heavy damage during earthquakes, which impart lateral loads to structures. In the Bhuj earthquake of Jan 26, 2001, that occurred in majority of masonry structures failed because they were built with un-reinforced brick masonry. The EBC code of practice for brick masonry, suggests the use of lintel band and roof band that introduce a rigid box-type behavior which will help the structure to improve its performance against seismic loads. But there are no Codal provisions for use of Rat-Trap bond masonry which has been found to possess good seismic resistance characteristics. Rat-Trap bond system consists of an array of headers and stretchers with bricks laid vertically on the edge to form a cavity within a set of two headers and two stretchers. In this investigation, an attempt has been made to study the behavior of un-reinforced Rat-Trap bond masonry of two categories viz., (i) with roof slab, and (ii) without roof slab. Shock-table tests on one-third scale masonry building models ( with and without roof slabs ) were carried out to study the behavior. The peak accelerations were recorded for each shock. The scaled bricks were obtained by cutting locally available bricks using special tools. The size of the masonry models was 2m x 1m x 1m. The amount of energy imparted during each shock was measured before total collapse both for Rat-Trap bond masonry models with and without roof slabs. The results of the tests revealed that the roof weight plays an important role in the design of Rat-Trap masonry systems subject to seismic loads.

Synthetic dyes in food can cause severe problems for health, so they need to be replaced by natural dyes. However, natural dyes are unstable, and encapsulation is one way to maintain the stability of natural dyes. This study was conducted to determine the best microencapsulation coating, storage stability, and color variations produced by butterfly pea, sappan wood, and turmeric extracts. The coating materials used were maltodextrin, carrageenan, and carboxy methyl cellulose (CMC) using the following formulations: 85% maltodextrin and 15% carrageenan (formula A) and 90% maltodextrin and 10% carrageenan (formula B) for coating butterfly pea and sappan wood extracts. Turmeric extracts were coating using 85% maltodextrin and 15% carrageenan (formula A) and 75% CMC and 25% starch (formula C). The encapsulation with maltodextrin (90%) and carrageenan (10%) was the best of encapsulation formula for butterfly pea and sappan wood extract. However, the encapsulation with maltodextrin (85%) and carrageenan (15%) was the best of encapsulation formula for turmeric extract. The green color was obtained from mixing butterfly pea and turmeric dyes in 1:4 ratio, purple from mixing butterfly pea and sappandyes in 1:8 ratio, and orange from mixing turmeric and sappan dyes in 1:2 ratio.

Objective: This research was conducted to examine the characteristics of the eugenol gel preparation in the Hydroxypropyl Methylcellulose (HPMC) gel base and to determine the profile of the release of eugenol from the HPMC gel base. Methods: Eugenol was made into gel preparations using HPMC base with concentrations of 3%, 5% and 7%. The evaluation included the tests of product characteristic and eugenol release. The product characteristic test included organoleptic examination (texture, color, and odor) and tests of spreadability, adhesion, and pH. The release test was carried out using cell diffusion and cellophane membranes. Results: All formulas met the pH requirements of topical products that were safe to use. The spreadability test is between 2.97-6.27 cm, adhesion test of products>4 s. The percentage of determination of eugenol content in the gel formula (F1 105.81%), (F2 93.28%) and (F3 98.87%). The cumulative amount of eugenol was F1 (2.563 mg/cm2), F2 (2.224 mg/cm2), and F3 (1.895 mg/cm2). Conclusion: The variation of HPMC as a gel base has effects on the adhesion, spreadability, and the eugenol gel release profile, where the greater the HPMC concentration, the smaller the spreadability, the greater the adhesion, and the lower the eugenol release profile. Based on the data obtained, the Formula 1 had a better release rate.

The forewing base structure of the orthopteran suborder Ensifera, a group of insects well known for their sound-producing behavior, was examined by using light microscopy, confocal laser scanning microscopy, and µCT. We detected significant novel characters, such as functional changes in the tpm9 muscle from the flexor to the extensor of the forewing that are likely associated with the acquisition of sound-producing behavior using forewings. Phylogenetic analysis based on the characters selected from the forewing base structure showed that the character system contains a strong phylogenetic signal supporting the monophyly of Ensifera, Tettigonioidea and Grylloidea as well as the sister-group relationship between Grylloidea and Gryllotalpoidea, but no apomorphies to resolve the deep phylogeny among superfamilies could be determined from this character system.

Introduction. A disadvantage of the ancestral method (la méthode ancestrale), which is widely used in the production of sparkling wine, is that it is difficult to control fermentation. We aimed to identify the optimal yeast race for obtaining high-quality young sparkling wines with varietal aroma without yeast tones. Study objects and methods. Our study objects were base and young sparkling wines from Cabernet-Sauvignon prepared on various yeast races. Organic acids, sugars, and ethanol contents were determined by high performance liquid chromatography. Phenolic and coloring substances were measured by colorimetric method. Foaming properties were determined by air barbotage of a wine sample in a measuring cylinder; sparkling properties, by measuring the CO2 desorption rate; CO2 content, by volumetric method; viscosity, with a viscometer. Sensory evaluation was carried out according to standard methods. Results and discussion. The wines produced on the Odesskiy Chernyi-SD13 yeast race received the highest tasting scores of 7.82 and 9.05 points for base wine and young sparkling wines, respectively. They contained larger amounts of phenolic substances (1103 mg/dm3) and coloring agents (275 mg/dm3) and had higher color intensity (1.614). The panelists rated them highly on their complex varietal aroma and harmonious, velvety flavor, as well as their foaming and sparkling properties. This yeast race ensured intensive fermentation of sugars and a great amount of bound CO2 (up to 24.93%). Conclusion. The Odesskiy Chernyi-SD13 yeast race is optimal for making base and young sparkling wines by the bottle method. This technology can be used to produce high-quality sparkling wines in the crop year by large and small enterprises.

Copper matrix composites (CMC) are frequently used in the automotive, aerospace, construction, and electrical-electronics industries. Properties such as low density, improved fatigue strength, high hardness, and high specific strength are the factors that make copper matrix composites important. The development of these factors is important for the industrial use of copper matrix composites. SiCp doped metal matrix composites have better mechanical properties than pure alloys. It is also known that Ti, B powder particle additives improve the mechanical properties of the main matrix. In this study, Cu hybrid composites reinforced with Ti–B-SiCp powders, which were not produced before, were obtained and their microstructure, density, hardness, and wear behavior were investigated. Composite materials produced by powder metallurgy method were prepared at 2–8 wt. % mixing ratios. Then each material was sintered at temperatures of 950–100-1050 °C. Microstructural images showed homogenous distribution in the composite material. The highest relative density of 93% was obtained in the composite material with a 2% reinforcement rate at 1050 °C. It was found that the hardness increased with the increase of the reinforcement rate up to 6 wt.% and then decreased after that. It was observed that the specific wear rate increased with the increasing reinforcement ratio. In addition, the lowest friction coefficient and wear temperature occurred at a sintering temperature of 1050 °C. In this study, it was reported that the sinter temperature value of 1050 °C is the optimum temperature value in terms of the tribological and mechanical performance of the materials.

SUMMARY The M= 8.1, 1 April 2014 Iquique earthquake, which broke part of the northern Chile seismic gap, was preceded by a strong foreshock sequence starting early January 2014. The reported analysis of the continuous records of the nearby GPS stations from the Integrated Plate Observatory Chile, North Chile array lead to contradictory results concerning the existence and location of slow slip events (SSEs) on the interplate contact. Resolving this controversy is an important issue, as although many SSEs are reported in subduction zones, only a few were found to be precursory to large earthquakes. Here we show that the records of a long base tiltmeter installed near Iquique, when corrected for coseismic steps, long-term drift, tidal signals and oceanic and atmospheric loading, show significant residual signals. These can be modelled with a sequence of four SSEs located close to Iquique. Their signature was already reported on some GPS stations, but their source was then characterized with a very low resolution in time and space, leading to contradicting models. With the tilt records, we can rule out the previously proposed models with a single large SSE closer to the main shock. Combining tilt with GPS records greatly improves the resolution of GPS alone, and one could locate their sources 100–180 km south–southeast to the main shock epicentre, with moment magnitudes between 5.8 and 6.2, at the edge of the main aftershock asperities. These moderate SSEs thus did not directly trigger the main shock, but contributed to trigger the main foreshock and the main aftershock. Only the sensitivity and resolution of the tiltmeter, added to the GPS records, allowed us to describe with unprecedented accuracy this precursory process as a cascade of cross-triggered, short-term aseismic slip events and earthquakes on the interplate contact. This three months of precursory activation appears to be the final acceleration burst of a weaker, longer term SSE which started mid-2013, already reported, with a moment release history which we could quantify. From the methodological point of view, our study takes advantage of an interesting complementarity of tilt and GPS measurements, due to their different dependence in distance to the source of strain, which turns out to be very efficient for resolving location and moment of strain sources, even when both instruments are close to each other. It finally demonstrates the efficient removal of sequences of small or even undetected coseismic steps from high resolution tilt record signal in order to retrieve the purely aseismic signal, a presently impossible task for high time resolution GPS records due to low signal to noise.

Purpose The boundary-layer analysis is required to reveal the fluid flow behavior in several industrial processes and enhance the products’ effectiveness. Therefore, this research aims to investigate the buoyancy or mixed convective stagnation-point flow (SPF) and heat transfer of a micropolar fluid filled with hybrid nanoparticles over a vertical plate. The nanoparticles silver (Ag) and titanium dioxide (TiO2) are scattered into various base fluids to form a new-fangled class of (Ag-TiO2/various base fluid) hybrid nanofluid along with different shape factors. Design/methodology/approach The self-similarity transformations are used to reformulate the leading requisite partial differential equations into renovated non-linear dimensionless ordinary differential equations. The numerical dual solutions are gained for the transmuted requisite equations with the help of the bvp4c built-in package in MATLAB software. The results are validated by comparing them with previously available published data for a particular case of the present study. Findings The impact of various pertaining parameters such as nanoparticle volume fraction, material parameter, shape factor and mixed convective on temperature, heat transfer, fluid motion, micro-rotation and drag force are visualized and scrutinized through tables and graphs. It is observed that dual or non-uniqueness outcomes are found for the case of buoyancy assisting flow, whereas the solution is unique in the buoyancy opposing flow case. Additionally, the fluid motion and micro-rotation profiles decelerate in the presence of nanoparticle volume fraction, while the temperature augments. Originality/value The mixed convective stagnation point flow conveying TiO2/Ag hybrid nanofluid with micropolar fluid with various shape factors is the significant originality of the current investigation where multiple outcomes are obtained for the assisting flow. The various base fluids such as glycerin, water and water–ethylene glycol (50%:50%) are considered in the present problem. The bifurcation values of the considered problem do not exist, probably because of various base fluids. To the best of the authors’ knowledge, this work is new and original which were not previously reported.

Aluminum alloys with electroplated coatings and copper plated in particular gained multiple applications. However, pre-zincate treatment often fails to provide the desired adhesion of the coating. We present the results of studying the effect of the electrolyte composition on the adhesion and other properties of the coating-base system. It is shown that an electrolyte with a reduced content of sulfuric and phosphoric acids can be used for anodizing and the oxide films formed during anodizing are stable in the usual copper-plating sulfuric acid electrolyte which eliminates contact exchange and increases adhesion. The use of a modern scratch-test method provides numerical determination of the values of adhesion of copper coatings. The adhesion value depends on the surface porosity of the oxide film and on the type of anodized alloys. The results can be used to improve the technology of applying copper coatings, both as an independent coating and as an underlayer in multilayer coatings.

В работе приведено численное моделирование пространственной задачи контактного взаимодействия ортотропных плит переменной жесткости с упругими основаниями. Используемая методика расчета пригодна в случае любых известных контактных моделей упругих оснований. В качестве примера приведены численные результаты для пространственно-неоднородных оснований типа упругих слоев постоянной и переменной толщины. Система интегро-дифференциальных уравнений, к которой сводится задача, решается численно, сочетанием методов конечных разностей типа сквозного счета и граничных элементов. Найдены прогибы, изгибающие моменты и распределения контактных давлений прямоугольной плиты переменной жесткости, полностью примыкающей к основанию. Приводится анализ влияния на напряженно-деформированное состояние плиты, изменения ортотропных свойств ее материала и степень неравномерной сжимаемости толщи грунта. Разработанная методика позволяет эффективно моделировать работу плитных фундаментных конструкций, когда необходим учет неоднородности грунтов сжимаемой толщи в пределах габарита зданий или сооружений. The paper presents a numerical simulation of the spatial problem of contact interaction of orthotropic slabs of variable stiffness with elastic foundations. The calculation technique used is suitable for any known contact models of elastic foundations. As an example, numerical results are given for spatially inhomogeneous foundations such as elastic layers of constant and variable thickness. The system of integrodifferential equations, to which the problem is reduced, is solved numerically by a combination of finite difference methods such as end-to-end counting and boundary elements. Deflections, bending moments and contact pressure distributions of a rectangular slab of variable stiffness, completely adjacent to the base, are found. An analysis of the influence on the stress-strain state of the slab of changes in the orthotropic properties of its material and the degree of uneven compressibility of the soil thickness is given. The developed technique makes it possible to effectively simulate the operation of slab foundation structures when it is necessary to take into account the heterogeneity of the soil of the compressible strata within the dimensions of buildings or structures.

In this work, we developed and validated a simple and selective method for the determination of titanium dioxide in double base solid (DB propellants). The method is based on complex formation of T...

Obtaining cheap and high-quality dry lubricant compositions based on local raw materials for stretching wires in the technology of obtaining small-sized wires from large-diameter wires. Dry lubricant obtained on the basis of local cheese is used for processing and drawing metals prepared from the following components: sodium soap, natriy sulphate Na2SO4 - 5.0-20.0; bura Na2B4O7·10H2O - 0.1-5.0 and talc. At present, the pilot-test work was carried out at a private company "DAVR METALL" in Namangan.

Clinical outcomes were reviewed in 30 patients treated by gamma knife radiosurgery for skull base meningiomas with carotid artery encasement (SKBM‐CAE). The overall clinical improvement rate after treatment was 46%. At a median imaging follow‐up of 49 months, tumor volumes were unchanged, were larger, and were smaller or had resolved in 70%, 23%, and 7% of cases, respectively. The crude survival rate at 10 years was 20% and the complication (new cranial nerve deficit not accompanied by imaging‐shown tumor growth) rate was 10%. SKBM‐CAE is amenable to being effectively and safely controlled with the application of gamma knife radiosurgery.

Information about the endonasal endoscopic approach (EEA) for the management of posttraumatic tension pneumocephalus (PTTP) remains scarce. Concomitant rhinoliquorrhea and posttraumatic hydrocephalus (PTH) can complicate the clinical course.The authors systematically reviewed pertinent articles published between 1961 and December 2020 and identified 6 patients with PTTP treated by EEA in 5 reports. Additionally, the authors share their institutional experience including a seventh patient, where an EEA resolved a recurrent PTTP without rhinoliquorrhea.Seven PTTP cases in which EEA was used as part of the treatment regime were included in this review. All cases presented with a defect in the anterior skull base, and 3 of them had concomitant rhinoliquorrhea. A transcranial approach was performed in 6/7 cases before EEA was considered to treat PTTP. In 4/7 cases, the PTTP resolved after the first intent; in 2/ 7 cases a second repair was necessary because of recurrent PTTP, 1 with and 1 without rhinoliquorrhea, and 1/7 case because of recurrent rhinoliquorrhea only. Overall, PTTP treated by EEA resolved with a mean radiological resolution time of 69 days (range 23-150 days), with no late recurrences. Only 1 patient developed a cerebrospinal fluid diversion infection probably related to a first incomplete EEA skull base defects repair. A permanent cerebrospinal fluid diversion was necessary in 3/7 cases.Endonasal endoscopic approach repair of air conduits is a safe and efficacious second-line approach after failed transcranial approaches for symptomatic PTTP. However, the strength of recommendation for EEA remains low until further evidence is presented.