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295 results on '"Basile, Umberto"'

4. Hypovitaminosis D and Leukocytosis to Predict Cardiovascular Abnormalities in Children with Kawasaki Disease: Insights from a Single-Center Retrospective Observational Cohort Study

Author

Rigante, Donato, primary, De Rosa, Gabriella, additional, Delogu, Angelica Bibiana, additional, Rotunno, Giulia, additional, Cianci, Rossella, additional, Di Pangrazio, Claudia, additional, Sodero, Giorgio, additional, Basile, Umberto, additional, and Candelli, Marcello, additional

Published
2024
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5. Spotlight on Syndecan 1 Role in Systemic Autoimmune Rheumatic Diseases: Main Actor or Guest Appearance?

Author

Carnazzo, Valeria, primary, Gulli, Francesca, additional, Basile, Valerio, additional, Di Santo, Riccardo, additional, Niccolini, Benedetta, additional, Redi, Serena, additional, Vinante, Ilaria, additional, Napodano, Cecilia, additional, Pocino, Krizia, additional, Rapaccini, Gian Ludovico, additional, Marino, Mariapaola, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2024
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6. Antenna-enhanced mid-infrared detection of extracellular vesicles derived from human cancer cell cultures

Author

Temperini, Maria Eleonora, Di Giacinto, Flavio, Romanò, Sabrina, Di Santo, Riccardo, Augello, Alberto, Polito, Raffaella, Baldassarre, Leonetta, Giliberti, Valeria, Papi, Massimiliano, Basile, Umberto, Niccolini, Benedetta, Krasnowska, Ewa K., Serafino, Annalucia, De Spirito, Marco, Di Gaspare, Alessandra, Ortolani, Michele, and Ciasca, Gabriele

Published
2022
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8. Salivary biomarkers in COVID-19 patients: the rabbit out of the hat!

Author

Napodano, Cecilia, primary, Callà, Cinzia Anna, additional, Fiorito, Antonella, additional, Marino, Mariapaola, additional, Taddei, Eleonora, additional, Cesare, Tiziana Di, additional, Passali, Giulio Cesare, additional, Santo, Riccardo Di, additional, Fantoni, Massimo, additional, Urbani, Andrea, additional, Paludetti, Gaetano, additional, Rapaccini, Gian Ludovico, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2024
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9. Serum Neurofilament and Free Light Chain Levels in Patients Undergoing Treatment for Chronic Inflammatory Demyelinating Polyneuropathy

Author

Luigetti, Marco, primary, Primiano, Guido, additional, Basile, Valerio, additional, Vitali, Francesca, additional, Pignalosa, Stefano, additional, Romano, Angela, additional, Sabino, Andrea, additional, Marino, Mariapaola, additional, Di Santo, Riccardo, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional

Published
2024
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10. Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study

Author

Gigante, Antonietta, primary, Cianci, Rosario, additional, Villa, Annalisa, additional, Pellicano, Chiara, additional, Giannakakis, Konstantinos, additional, Rosato, Edoardo, additional, Spinelli, Francesca Romana, additional, Basile, Umberto, additional, Racco, Cosimo, additional, Di Virgilio, Elena Maria, additional, Cerbelli, Bruna, additional, and Conti, Fabrizio, additional

Published
2024
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13. Indicazioni per l'armonizzazione del referto dell'elettroforesi delle sieroproteine e della tipizzazione delle componenti monoclonali.

Author

Savoia, Marcella, Michetti, Laura, Cigliana, Giovanni, Turra, Fiorella, Debbia, Daria, Visconti, Valeria, Altinier, Sara, Gelsumini, Silvia, Basile, Umberto, Natali, Patrizia, Pieri, Massimo, Cataldo, Ivana, Mussap, Michele, Graziani, Maria Stella, and Palladini, Giovanni

Abstract

The Italian Society of Clinical Biochemistry and Molecular Biology (SIBioC) has long promoted harmonizing activities, focusing on the laboratory reports to guarantee accuracy and comparability of the results. There is a wealth of guidelines on the clinical usefulness and diagnostic accuracy of serum protein electrophoresis (SPE), but only few provide specific recommendations for reporting and commenting the results. According to surveys and international multi-center studies, there is considerable variability between SPE reports among laboratories, which negatively impacts the management of patients with monoclonal gammopaties (MGs). This document issued by the SIBioC Study Group on Proteins, provides guidance on how to standardize and harmonize laboratory SPE reports, formulated on the basis on the available reference literature as well as on expert consensus. Each SPE report should be accompanied by a descriptive comment, mainly related to the management of samples with monoclonal components (detection, quantification and immunotyping). Examples of comments are provided. Special attention should be dedicated to samples showing a possible interference by therapeutic monoclonal antibodies (tmAb) currently used for the treatment of Multiple Myeloma (MM). Failure to detect interference due to tmAb can lead to further unnecessary diagnostic procedures or incorrect interpretations of the efficacy of treatment, such as the failure to detect a complete response to treatment in MM patients. Close collaboration between laboratory professionals and clinicians is therefore of paramount importance to provide correct information that will be useful in every step of the management of MGs patients. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Calprotectin: two sides of the same coin

Author

Carnazzo, Valeria, primary, Redi, Serena, additional, Basile, Valerio, additional, Natali, Patrizia, additional, Gulli, Francesca, additional, Equitani, Francesco, additional, Marino, Mariapaola, additional, and Basile, Umberto, additional

Published
2023
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18. Calprotectin: two sides of the same coin.

Author

Carnazzo, Valeria, Redi, Serena, Basile, Valerio, Natali, Patrizia, Gulli, Francesca, Equitani, Francesco, Marino, Mariapaola, and Basile, Umberto

Subjects
FECAL analysis, AUTOIMMUNE disease diagnosis, AUTOANTIBODIES, BIOMARKERS, INFLAMMATORY bowel diseases, CHRONIC diseases, AUTOIMMUNE diseases, PATIENT monitoring, NEUTROPHILS, CALCIUM-binding proteins, MONOCYTES
Abstract

Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in the course of inflammation. Today, the role of faecal CLP in chronic IBD is well known, but in recent years attention has shifted towards circulating CLP. In fact, this molecule can be measured in different biological fluids: blood, saliva and urine, using different analytic methods that are described in this review. Furthermore, different data confirm the relevant role of serum CLP in autoimmune diseases. In this review we will highlight the correlation between high levels of circulating CLP and specific autoantibodies of major autoimmune pathologies paving the way to the employment of CLP measurement as useful biomarker for monitoring outcome in different pathologies. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Serological and Molecular Characterization of Hepatitis C Virus-Related Cryoglobulinemic Vasculitis in Patients without Cryoprecipitate

Author

Napodano, Cecilia, primary, Ciasca, Gabriele, additional, Chiusolo, Patrizia, additional, Pocino, Krizia, additional, Gragnani, Laura, additional, Stefanile, Annunziata, additional, Gulli, Francesca, additional, Lorini, Serena, additional, Minnella, Gessica, additional, Fosso, Federica, additional, Di Santo, Riccardo, additional, Romanò, Sabrina, additional, Basile, Valerio, additional, De Stefano, Valerio, additional, Rapaccini, Gian Ludovico, additional, Zignego, Anna Linda, additional, Di Stasio, Enrico, additional, Marino, Mariapaola, additional, and Basile, Umberto, additional

Published
2023
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21. Free light chains: novel serum biomarkers for NASH stratification, an update

Author

Liguori, Antonio, primary, Basile, Umberto, additional, D’Ambrosio, Francesca, additional, Napodano, Cecilia, additional, Tomasello, Lidia, additional, Mancuso, Fabrizio, additional, Marrone, Giuseppe, additional, Biolato, Marco, additional, Rapaccini, Gianludovico, additional, Gasbarrini, Antonio, additional, Grieco, Antonio, additional, and Miele, Luca, additional

Published
2023
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23. Laboratory and Clinical Settings of Heavy/Light Chain (HLC) Assays in the Management of Monoclonal Gammopathies and Multiple Myeloma

Author

Napodano, Cecilia, primary, Ioannilli, Laura, additional, Basile, Valerio, additional, Gulli, Francesca, additional, Carnazzo, Valeria, additional, Pignalosa, Stefano, additional, Di Biase, Luigi, additional, Cavaleri, Erica, additional, Racco, Cosimo, additional, Equitani, Francesco, additional, Marino, Mariapaola, additional, and Basile, Umberto, additional

Published
2023
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24. Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients

Author

Pellicano, Chiara, primary, Colalillo, Amalia, additional, Cusano, Giuseppina, additional, Palladino, Andrea, additional, Pellegrini, Marica, additional, Callà, Cinzia Anna Maria, additional, Mazzuccato, Giorgia, additional, Carnazzo, Valeria, additional, Pignalosa, Stefano, additional, Di Biase, Luigi, additional, Marino, Mariapaola, additional, Basile, Umberto, additional, and Rosato, Edoardo, additional

Published
2023
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25. In Systemic Sclerosis Patients, Peripheral Blood CD21 low B Cells and Serum IL-4 and IL-21 Influence Joint Involvement.

Author

Pellicano, Chiara, Colalillo, Amalia, Carnazzo, Valeria, Redi, Serena, Basile, Valerio, Marino, Mariapaola, Basile, Umberto, and Rosato, Edoardo

Subjects
B cells, SYSTEMIC scleroderma, LOGISTIC regression analysis
Abstract

Systemic sclerosis (SSc) patients have an increased frequency of CD21low B cells and of serum interleukin-4 (IL-4) and IL-21, each possible markers of joint involvement in inflammatory arthritis. The aim of this study was to investigate the possible influence of CD21low B cells, IL-4, and IL-21 on joint involvement in a cohort of 52 SSc patients. The DAS28-ESR was correlated with CD21low B cells (r = 0.452, p < 0.001), IL-4 (r = 0.478, p < 0.001), and IL-21 (r = 0.415, p < 0.001). SSc patients with a DAS28-ESR > 3.2 had more CD21low B cells (12.65% (IQR: 7.11–13.79) vs. 5.08% (IQR: 3.76–7.45), p < 0.01), higher IL-4 levels (132.98 pg/mL (IQR: 99.12–164.12) vs. 100.80 pg/mL (IQR: 62.78–121.13), p < 0.05), and higher IL-21 levels (200.77 pg/mL (IQR: 130.13–302.41) vs. 98.83 pg/mL (IQR: 35.70–231.55), p < 0.01) than patients with a DAS28-ESR ≤ 3.2. The logistic regression analysis models showed that the DAI (OR: 2.158 (95% CI: 1.120; 4.156), p < 0.05) and CD21low B cells (OR: 1.301 (95% CI: 1.099; 1.540), p < 0.01), the DAI (OR: 2.060 (95% CI: 1.082; 3.919), p < 0.05) and IL-4 level (OR: 1.026 (95% CI: 1.006; 1.045), p < 0.01), and the DAI (OR: 1.743 (95% CI: 1.022; 2.975), p < 0.05) and IL-21 level (OR: 1.006 (95% CI: 1.000; 1.011), p < 0.05) were independently associated with a DAS28-ESR > 3.2. An elevated CD21low B cell percentage, IL-4 level, and IL-21 level was associated with higher articular disease activity in patients, suggesting a possible role in the pathogenesis of SSc joint involvement. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Crioproteinemia: nuove frontiere per i clinici e il laboratorio.

Author

Natali, Patrizia, Debbia, Daria, Troiano, Teresa, Napodano, Cecilia, Spinella, Amelia, Amati, Gabriele, Filippini, Davide, Zani, Roberta, Alfano, Gaetano, Colaci, Elisabetta, Maccaferri, Monica, Galassi, Giuliana, Mazzoli, Marco, Ariatti, Alessandra, Basile, Umberto, Mascia, Maria Teresa, Palladini, Giovanni, Giuggioli, Dilia, and Sandri, Gilda

Abstract

Cryoproteinaemia is characterised by the presence of detectable proteins in both serum and plasma that precipitate at 4°C and dissolve at 37°C. Cryoglobulins are constituted by immunoglobulins and are detectable in both serum and plasma, whereas cryofibrinogen is detectable only in plasma. The importance of studying cryoproteinemia was the main theme of the meeting held in Modena in March 2023, entitled: Cryoglobulinemia. Laboratory and clinic, a fruitful collaboration for the correct management of a rare pathology - 4th edition, organised by the Italian Society of Clinical Biochemistry and Molecular Biology (SIBioC) and the Italian Association for the fight against Cryoglobulinaemia (ALCRI). The aim of this conference is to promote a dialogue between clinicians and laboratory professionals, highlighting the information that the clinician expects from the laboratory and the critical points that the laboratory faces when performing a test that is still predominantly performed manually. During the meeting, data from three laboratories were presented and compared, and a group of clinicians who deal with cryoproteinemia in different medical fields -- rheumatologists, nephrologists, haematologists, and neurologists -- contributed their experience in treating patients with cryoproteinemia. The collaboration between laboratory and clinic and the respective scientific societies (SIBioC and ALCRI) have made possible to draw a common line to guide both entities in their daily activity. The road seems long and complex, but a common system is emerging from this interaction, the fruits from which patient will benefit. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace

Author

Pocino, Krizia, primary, Stefanile, Annunziata, additional, Basile, Valerio, additional, Napodano, Cecilia, additional, D’Ambrosio, Francesca, additional, Di Santo, Riccardo, additional, Callà, Cinzia Anna Maria, additional, Gulli, Francesca, additional, Saporito, Raffaele, additional, Ciasca, Gabriele, additional, Equitani, Francesco, additional, Basile, Umberto, additional, and Marino, Mariapaola, additional

Published
2022
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29. Circulating and Salivary NGF and BDNF Levels in SARS-CoV-2 Infection: Potential Predictor Biomarkers of COVID-19 Disease—Preliminary Data

Author

Biamonte, Filippo, primary, Re, Agnese, additional, Balzamino, Bijorn Omar, additional, Ciasca, Gabriele, additional, Santucci, Daniela, additional, Napodano, Cecilia, additional, Nocca, Giuseppina, additional, Fiorita, Antonella, additional, Marino, Mariapaola, additional, Basile, Umberto, additional, Micera, Alessandra, additional, and Callà, Cinzia Anna Maria, additional

Published
2022
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30. PMON255 Inflammation and Oxidative Stress in Seminal Plasma: Role of Free Light Chains of Immunoglobulins and Antioxidants as Biomarkers in Male Infertility

Author

Bruno, Carmine, primary, Vergani, Edoardo, additional, Oliva, Alessandro, additional, Basile, Umberto, additional, Napodano, Cecilia, additional, Gulli, Francesca, additional, Silvestrini, Andrea, additional, Meucci, Elisabetta, additional, Orlando, Patrick, additional, Silvestri, Sonia, additional, Tiano, Luca, additional, and Mancini, Antonio, additional

Published
2022
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34. Sensing red blood cell nano-mechanics: Toward a novel blood biomarker for Alzheimer’s disease

Author

Nardini, Matteo, primary, Ciasca, Gabriele, additional, Lauria, Alessandra, additional, Rossi, Cristina, additional, Di Giacinto, Flavio, additional, Romanò, Sabrina, additional, Di Santo, Riccardo, additional, Papi, Massimiliano, additional, Palmieri, Valentina, additional, Perini, Giordano, additional, Basile, Umberto, additional, Alcaro, Francesca D., additional, Di Stasio, Enrico, additional, Bizzarro, Alessandra, additional, Masullo, Carlo, additional, and De Spirito, Marco, additional

Published
2022
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36. Different aspects of severe asthma in real life: Role of Staphylococcus aureus enterotoxins and correlation to comorbidities and disease severity

Author

Caruso, Cristiano, primary, Colantuono, Stefania, additional, Ciasca, Gabriele, additional, Basile, Umberto, additional, Di Santo, Riccardo, additional, Bagnasco, Diego, additional, Passalacqua, Giovanni, additional, Caminati, Marco, additional, Michele, Schiappoli, additional, Senna, Gianenrico, additional, Heffler, Enrico, additional, Canonica, G. Walter, additional, Crimi, Nunzio, additional, Intravaia, Rossella, additional, De Corso, Eugenio, additional, Firinu, Davide, additional, Gasbarrini, Antonio, additional, and Del Giacco, Stefano R., additional

Published
2022
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37. Free Light Chains as a potential biomarker of inflammation and fibrosis in non-alcoholic steatohepatitis

Author

Liguori, Antonio, primary, Basile, Umberto, additional, Napodano, Cecilia, additional, Tomasello, Lidia, additional, Mancuso, Fabrizio, additional, Di Gialleonardo, Luca, additional, Marrone, Giuseppe, additional, Biolato, Marco, additional, Gasbarrini, Antonio, additional, Rapaccini, Gian Ludovico, additional, Grieco, Antonio, additional, and Miele, Luca, additional

Published
2022
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39. Inflammation and Oxidative Stress in Seminal Plasma: Search for Biomarkers in Diagnostic Approach to Male Infertility

Author

Bruno, Carmine, primary, Basile, Umberto, additional, Vergani, Edoardo, additional, Napodano, Cecilia, additional, Oliva, Alessandro, additional, Gulli, Francesca, additional, Meucci, Elisabetta, additional, Silvestrini, Andrea, additional, Orlando, Patrick, additional, Silvestri, Sonia, additional, Tiano, Luca, additional, and Mancini, Antonio, additional

Published
2022
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40. B‐cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non‐Hodgkin's Lymphoma

Author

Gragnani, Laura, primary, Lorini, Serena, additional, Marri, Silvia, additional, Rattotti, Sara, additional, Madia, Francesco, additional, Zibellini, Silvia, additional, Monti, Monica, additional, Basile, Umberto, additional, Di Stasio, Enrico, additional, Libra, Massimo, additional, Arcaini, Luca, additional, and Zignego, Anna Linda, additional

Published
2022
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45. Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace.

Author

Pocino, Krizia, Stefanile, Annunziata, Basile, Valerio, Napodano, Cecilia, D'Ambrosio, Francesca, Di Santo, Riccardo, Callà, Cinzia Anna Maria, Gulli, Francesca, Saporito, Raffaele, Ciasca, Gabriele, Equitani, Francesco, Basile, Umberto, and Marino, Mariapaola

Subjects
HEPATOCELLULAR carcinoma, SOMATIC mutation, CYTOKINES, GROWTH factors, ANGIOPOIETINS
Abstract

Hepatocellular carcinoma (HCC) represents a worldwide health matter with a major care burden, high prevalence, and poor prognosis. Its pathogenesis mainly varies depending on the underlying etiological factors, although it develops from liver cirrhosis in the majority of cases. This review summarizes the role of the most interesting soluble factors as biomarkers for early diagnosis and as recommended targets for treatment in accordance with the new challenges in precision medicine. In the premalignant environment, inflammatory cells release a wide range of cytokines, chemokines, growth factors, prostaglandins, and proangiogenic factors, making the liver environment more suitable for hepatocyte tumor progression that starts from acquired genetic mutations. A complex interaction of pro-inflammatory (IL-6, TNF-α) and anti-inflammatory cytokines (TGF-α and -β), pro-angiogenic molecules (including the Angiopoietins, HGF, PECAM-1, HIF-1α, VEGF), different transcription factors (NF-kB, STAT-3), and their signaling pathways are involved in the development of HCC. Since cytokines are expressed and released during the different stages of HCC progression, their measurement, by different available methods, can provide in-depth information on the identification and management of HCC. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Different aspects of severe asthma in real life: Role of Staphylococcus aureus enterotoxins and correlation to comorbidities and disease severity.

Author

Caruso, Cristiano, Colantuono, Stefania, Ciasca, Gabriele, Basile, Umberto, Di Santo, Riccardo, Bagnasco, Diego, Passalacqua, Giovanni, Caminati, Marco, Michele, Schiappoli, Senna, Gianenrico, Heffler, Enrico, Canonica, G. Walter, Crimi, Nunzio, Intravaia, Rossella, De Corso, Eugenio, Firinu, Davide, Gasbarrini, Antonio, and Del Giacco, Stefano R.

Subjects
STAPHYLOCOCCUS aureus, ENTEROTOXINS, ASTHMA, FOOD poisoning, NASAL polyps, COMORBIDITY, ATOPY
Abstract

Background: Asthma, with several phenotypes and endotypes, is considered particularly suited for precision medicine. The identification of different non‐invasive biomarkers may facilitate diagnosis and treatment. Recently, Staphylococcus aureus and its enterotoxins (SE) have been found to have a role in inducing persistent type 2 airway inflammation in severe asthma, but also in such comorbidities as chronic rhinosinusitis with nasal polyposis (CRSwNP). Methods: The aim of this retrospective study was to evaluate the prevalence of SE‐IgE sensitization in a multicentric Italian cohort of severe asthmatic patients and correlate it with demographic and clinical characteristics. Results: A total of 249 patients were included in the analysis, out of which 25.3% were staphylococcal enterotoxin B (SEB)‐IgE positive. We found a meaningful association between SEB‐IgE and female gender, a positive association was also measured between CRS and CRSwNP. No significant association was found between SEB‐IgE sensitization and atopy, the occurrence of exacerbations and corticosteroid dosages. In the SEB‐IgE‐positive patient, blood eosinophil count does not appear to be correlated with the severity of the disease. Patients with SEB‐IgE sensitization are, on average, younger and with an earlier disease onset, thus confirming the possibility to consider SEB‐IgE sensitization as an independent risk factor for developing asthma. Conclusions: Our data confirm that the search for SE in the initial screening phase of these patients is helpful to better phenotype them, may predict the evolution of comorbidities and lead to a targeted therapeutic choice; in this point of view this represents a goal of precision medicine. [ABSTRACT FROM AUTHOR]

Published
2023
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