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36 results on '"Bassim, Carol"'

11. Infectious diseases, comorbidities and outcomes in hospitalized people who inject drugs (PWID) infections in persons who inject drugs

Author

Lim, Jacqueline, primary, Pavalagantharajah, Sureka, additional, Verschoor, Chris P, additional, Lentz, Eric, additional, Loeb, Mark, additional, Levine, Mitchell, additional, Smieja, Marek, additional, Mbuagbaw, Lawrence, additional, Kalina, Dale, additional, Tarride, Jean-Eric, additional, O’Shea, Tim, additional, Cvetkovic, Anna, additional, van Gaalen, Sarah, additional, Findlater, Aidan Reid, additional, Lennox, Robin, additional, Bassim, Carol, additional, Lokker, Cynthia, additional, and Alvarez, Elizabeth, additional

Published
2022
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12. National Institutes of Health Chronic Graft-versus-Host Disease Staging in Severely Affected Patients: Organ and Global Scoring Correlate with Established Indicators of Disease Severity and Prognosis

Author

Baird, Kristin, Steinberg, Seth M., Grkovic, Lana, Pulanic, Drazen, Cowen, Edward W., Mitchell, Sandra A., Williams, Kirsten M., Datiles, Manuel B., Bishop, Rachel, Bassim, Carol W., Mays, Jacqueline W., Edwards, Dean, Cole, Kristen, Avila, Daniele N., Taylor, Tiffany, Urban, Amanda, Joe, Galen O., Comis, Leora E., Berger, Ann, Stratton, Pamela, Zhang, Dan, Shelhamer, James H., Gea-Banacloche, Juan C., Sportes, Claude, Fowler, Daniel H., Gress, Ronald E., and Pavletic, Steven Z.

Published
2013
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13. Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral chronic graft-versus-host disease

Author

Costa-da-Silva, Ana Caroline, primary, Aure, Marit H., additional, Dodge, Joshua, additional, Martin, Daniel, additional, Dhamala, Susan, additional, Cho, Monica, additional, Rose, Jeremy J., additional, Bassim, Carol W., additional, Ambatipudi, Kiran, additional, Hakim, Frances T., additional, Pavletic, Steven Z., additional, and Mays, Jacqueline W., additional

Published
2022
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16. Reliability and Minimal Detectable Change Values for Performance-Based Measures of Physical Functioning in the Canadian Longitudinal Study on Aging

Author

Beauchamp, Marla K, primary, Hao, Qiukui, additional, Kuspinar, Ayse, additional, D’Amore, Cassandra, additional, Scime, Giulia, additional, Ma, Jinhui, additional, Mayhew, Alexandra, additional, Bassim, Carol, additional, Wolfson, Christina, additional, Kirkland, Susan, additional, Griffith, Lauren, additional, and Raina, Parminder, additional

Published
2021
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19. Salivary ZG16B Expression Loss Marks Onset of Oral Chronic Graft-Versus-Host Disease and Exocrine Gland Dysfunction

Author

Costa-da-Silva, Ana Caroline, primary, Aure, Marit H., additional, Dodge, Joshua, additional, Martin, Daniel, additional, Dhamala, Susan, additional, Cho, Monica, additional, Rose, Jeremy J., additional, Bassim, Carol W., additional, Ambatipudi, Kiran, additional, Hakim, Frances T., additional, Pavletic, Steven Z., additional, and Mays, Jacqueline W., additional

Published
2021
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24. Salivary Zymogen Granule Protein 16B Drops at Onset of Chronic Graft-Versus-Host Disease: A Possible Salivary Biomarker for Oral Chronic Graft-Versus-Host Disease

Author

da Silva, Ana Caroline Costa, primary, Dodge, Joshua, additional, Dhamala, Susan, additional, Do, Kim T., additional, Cho, Monica, additional, Rose, Jeremy J., additional, Bassim, Carol W., additional, Ambatipudi, Srinivaskiran, additional, Swatkoski, Stephen, additional, Gucek, Marjan, additional, Hakim, Fran T., additional, Pavletic, Steven Z., additional, and Mays, Jacqueline W., additional

Published
2019
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25. Self‐reported oral health at baseline of the Canadian Longitudinal Study on Aging.

Author

Bassim, Carol W., MacEntee, Michael I., Nazmul, Sohel, Bedard, Chloe, Liu, Siying, Ma, Jinhui, Griffith, Lauren E., and Raina, Parminder

Subjects
*AGE distribution, *AGING, *CHRONIC diseases, *COMPARATIVE studies, *DENTAL care, *HEALTH attitudes, *HEALTH status indicators, *INCOME, *LONGITUDINAL method, *ORAL hygiene, *SELF-evaluation, *SEX distribution, *SMOKING, *TOOTH loss, *MULTIPLE regression analysis, *RESIDENTIAL patterns, *SOCIOECONOMIC factors, *DISEASE prevalence, *ODDS ratio
Abstract

Objectives: To compare the prevalence of poor self‐reported oral health (SROH) and dental service‐use in a representative sample of Canadian residents, and to identify associations between SROH and psychosocial determinants of health at baseline of the Canadian Longitudinal Study on Aging. Methods: Data from baseline interviews from 2010 to 2015 involving 93% of 51 388 adults (n = 47 761) were weighted to compare the prevalence of oral health characteristics adjusted for age, sex, socioeconomics, general health and residence. SROH was assessed as 'excellent', 'very good', 'good', 'fair' or 'poor', and dichotomized as 'fair/poor' and 'good/very good/excellent'. Multivariable logistic regression was used to assess the association of fair/poor oral health with psychosocial determinants of health. Results: Most participants reported 'good/very good/excellent' oral health (92.5%), natural teeth (92.0%) and dental service‐use in the previous year (79.6%), yet over 10% had discomfort when eating. Reports of 'fair/poor' oral health were significantly more frequent among participants who had dental concerns, had low socioeconomic status, smoked tobacco or reported poor general health. Dental service‐use and tooth loss differed by province. The odds of poor/fair SROH were high (odds ratio ≥1.5) among participants who avoided foods, did not use dental services frequently, had low incomes, smoked tobacco, were depressed, felt unhealthy or had multiple chronic conditions, but by neither sex or age. There were no interprovincial differences. Conclusions: Most Canadian residents feel in good oral health and use dental services. Oral health inequality is evident between different socioeconomic groups and between healthy and unhealthy people. SROH is strongly associated with socioeconomic and general health status but not with place of residence. However, there were substantial differences in reports of tooth loss and dental service‐use across provinces. [ABSTRACT FROM AUTHOR]

Published
2020
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27. A Randomized Phase 2 Placebo Controlled Trial of Clobetasol Rinse for Treatment of Oral Chronic Graft-Versus-Host Disease

Author

Mays, Jacqueline W., primary, Curtis, Lauren M., additional, Bassim, Carol, additional, Steinberg, Seth M., additional, Venzon, David, additional, Rose, Jeremy J., additional, Cho, Monica, additional, Kanakry, Christopher G., additional, Yazdanie, Fahd, additional, Avila, Daniele, additional, Baird, Kristin, additional, Hsu, Jennifer, additional, Masuch, Licia, additional, Grimes, George, additional, Starling, Judith, additional, Fowler, Daniel H., additional, Gress, Ronald E., additional, Hakim, Fran T., additional, and Pavletic, Steven Z., additional

Published
2016
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29. National Institutes of Health (NIH) Chronic GVHD Staging in Severely Affected Patients: Organ and Global Scoring Correlate with Established Indicators of Disease Severity and Prognosis

Author

Baird, Kristin, Steinberg, Seth M., Grković, Lana, Pulanić, Dražen, Cowen, Edward W., Mitchell, Sandra A., Williams, Kirsten M., Datiles, Manuel B., Bishop, Rachel, Bassim, Carol W., Mays, Jacqueline W., Edwards, D., Cole K., Avila, Daniele N., Taylor, Tiffani T., Urban, A., Joe, Galen O., Comis, Leora E., Berger, A., Stratton, Pamela, Zhang, Dan, Shelhamer, J.H., Gea-Banacloche, Juan C., Sportes, C., Fowler, Daniel H., Gress, Ronald E., and Pavletić, Steven Živko

Subjects
National Institutes of Health, Chronic graft-versus-host disease, Consensus Criteria, Lung dysfunction, Sclerotic skin, Stem cell transplant
Abstract

Between 2004 and 2010, 189 adult patients were enrolled on the National Cancer Institute's cross-sectional chronic graft-versus-host disease (cGVHD) natural history study. Patients were evaluated by multiple disease scales and outcome measures, including the 2005 National Institutes of Health (NIH) Consensus Project cGVHD severity scores. The purpose of this study was to assess the validity of the NIH scoring variables as determinants of disease severity in severely affected patients in efforts to standardize clinician evaluation and staging of cGVHD. Out of 189 patients enrolled, 125 met the criteria for severe cGVHD on the NIH global score, 62 of whom had moderate disease, with a median of 4 (range, 1-8) involved organs. Clinician-assigned average NIH organ score and the corresponding organ scores assigned by subspecialists were highly correlated (r = 0.64). NIH global severity scores showed significant associations with nearly all functional and quality of life outcome measures, including the Lee Symptom Scale, Short Form-36 Physical Component Scale, 2-minute walk, grip strength, range of motion, and Human Activity Profile. Joint/fascia, skin, and lung involvement affected function and quality of life most significantly and showed the greatest correlation with outcome measures. The final Cox model with factors jointly predictive for survival included the time from cGVHD diagnosis (>49 versus ≤49 months, hazard ratio [HR] = 0.23 ; P = .0011), absolute eosinophil count at the time of NIH evaluation (0-0.5 versus >0.5 cells/μL, HR = 3.95 ; P = .0006), and NIH lung score (3 versus 0-2, HR = 11.02 ; P < .0001). These results demonstrate that NIH organs and global severity scores are reliable measures of cGVHD disease burden. The strong association with subspecialist evaluation suggests that NIH organ and global severity scores are appropriate for clinical and research assessments, and may serve as a surrogate for more complex subspecialist examinations. In this population of severely affected patients, NIH lung score is the strongest predictor of poor overall survival, both alone and after adjustment for other important factors.

Published
2013

31. Chronic Graft-Versus-Host Disease (cGVHD) Patients with Bronchiolitis Obliterans Syndrome (BOS) Have Worse Clinical Manifestations and Severity of cGVHD with More Impairment in Self-Assessed Physical and Mental Health than cGVHD Patients without BOS

Author

Grkovic, Lana, primary, Pulanic, Drazen, additional, Steinberg, Seth M., additional, Williams, Kirsten M., additional, Baird, Kristin, additional, Mitchell, Sandra A., additional, Cowen, Edward W., additional, Datiles, Manuel B., additional, Bassim, Carol W., additional, Galen, Joe, additional, Comis, Leora, additional, Avila, Daniele N., additional, Taylor, Tiffani N., additional, Zhang, Dan, additional, Cole, Kristen, additional, Fowler, Dan H., additional, Hakim, Frances T., additional, Gress, Ronald E., additional, and Pavletic, Steven Z., additional

Published
2012
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32. Denosumab treatment for fibrous dysplasia

Author

Boyce, Alison M, primary, Chong, William H, additional, Yao, Jack, additional, Gafni, Rachel I, additional, Kelly, Marilyn H, additional, Chamberlain, Christine E, additional, Bassim, Carol, additional, Cherman, Natasha, additional, Ellsworth, Michelle, additional, Kasa‐Vubu, Josephine Z, additional, Farley, Frances A, additional, Molinolo, Alfredo A, additional, Bhattacharyya, Nisan, additional, and Collins, Michael T, additional

Published
2012
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33. Dual antiangiogenic therapy using lenalidomide and bevacizumab with docetaxel and prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC).

Author

Adesunloye, Bamidele, primary, Huang, Xuan, additional, Ning, Yangmin M., additional, Madan, Ravi A., additional, Gulley, James L., additional, Beatson, Melony, additional, Kluetz, Paul Gustav, additional, Adelberg, David E., additional, Arlen, Philip M., additional, Parnes, Howard L., additional, Mulquin, Marcia, additional, Steinberg, Seth M., additional, Wright, John Joseph, additional, Trepel, Jane B., additional, Dawson, Nancy Ann, additional, Chen, Clara, additional, Bassim, Carol, additional, Apolo, Andrea Borghese, additional, Figg, William Douglas, additional, and Dahut, William L., additional

Published
2012
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34. Assessing the Validity of the NIH Response Criteria for Chronic Graft-Versus-Host Disease (cGVHD): Consensus Measures Correlate with Clinical Outcomes,

Author

Grkovic, Lana, primary, Mitchell, Sandra A., additional, Baird, Kristin, additional, Steinberg, Seth M., additional, Cowen, Edward W., additional, Williams, Kirsten M., additional, Datiles, Manuel B., additional, Aria, Dean, additional, Bassim, Carol, additional, Joe, Galen, additional, Comis, Leora, additional, Pulanic, Drazen, additional, Baruffaldi, Judy, additional, Zhang, Dan, additional, Sportes, Claude, additional, Salit, Rachel B., additional, Fowler, Dan H., additional, Hakim, Frances T., additional, Gress, Ronald E., additional, and Pavletic, Steven Z., additional

Published
2011
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36. Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral chronic graft-versus-host disease.

Author

Costa-da-Silva AC, Aure MH, Dodge J, Martin D, Dhamala S, Cho M, Rose JJ, Bassim CW, Ambatipudi K, Hakim FT, Pavletic SZ, and Mays JW

Abstract

Chronic graft-versus-host disease (cGVHD) targets include the oral mucosa and salivary glands after allogeneic hematopoietic stem cell transplant (HSCT). Without incisional biopsy, no diagnostic test exists to confirm oral cGVHD. Consequently, therapy is often withheld until severe manifestations develop. This proteomic study examined saliva and human salivary gland for a biomarker profile at first onset of oral cGVHD prior to initiation of topical steroid therapy. Whole saliva collected at onset of biopsy-proven oral GVHD was assessed using liquid chromatography-coupled tandem mass spectrometry with identification of 569 proteins, of which 77 significantly changed in abundance. ZG16B, a secretory lectin protein, was reduced 2-fold in oral cGVHD saliva (p <0.05), and significantly decreased in salivary gland secretory cells affected by cGVHD. Single-cell RNA-seq analysis of healthy MSG localized ZG16B expression to two discrete acinar cell populations. Reduced ZG16B expression may indicate specific cGVHD activity and possibly general salivary gland dysfunction., Competing Interests: No competing interests from the authors., (© 2021.)

Published
2021
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