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6. Infertility treatment and postpartum mental illness: a population-based cohort study.

Author

Dayan, N, Velez, MP, Vigod, S, Pudwell, J, Djerboua, M, Fell, DB, Basso, O, Nguyen, TV, Joseph, KS, Ray, JG, Dayan, N, Velez, MP, Vigod, S, Pudwell, J, Djerboua, M, Fell, DB, Basso, O, Nguyen, TV, Joseph, KS, and Ray, JG

Abstract

BACKGROUND: Subfertility and infertility treatment can be stressful experiences, but it is unknown whether each predisposes to postpartum mental illness. We sought to evaluate associations between subfertility or infertility treatment and postpartum mental illness. METHODS: We conducted a population-based cohort study of individuals without pre-existing mental illness who gave birth in Ontario, Canada, from 2006 to 2014, stratified by fertility exposure: subfertility without infertility treatment; noninvasive infertility treatment (intrauterine insemination); invasive infertility treatment (in vitro fertilization); and no reproductive assistance. The primary outcome was mental illness occurring 365 days or sooner after birth (defined as ≥ 2 outpatient visits, an emergency department visit or a hospital admission with a mood, anxiety, psychotic, or substance use disorder, self-harm event or other mental illness). We used multivariable Poisson regression with robust error variance to assess associations between fertility exposure and postpartum mental illness. RESULTS: The study cohort comprised 786 064 births (mean age 30.42 yr, standard deviation 5.30 yr), including 78 283 with subfertility without treatment, 9178 with noninvasive infertility treatment, 9633 with invasive infertility treatment and 688 970 without reproductive assistance. Postpartum mental illness occurred in 60.8 per 1000 births among individuals without reproductive assistance. Relative to individuals without reproductive assistance, those with subfertility had a higher adjusted relative risk of postpartum mental illness (1.14, 95% confidence interval 1.10-1.17), which was similar in noninvasive and invasive infertility treatment groups. INTERPRETATION: Subfertility or infertility treatment conferred a slightly higher risk of postpartum mental illness compared with no reproductive assistance. Further research should elucidate whether the stress of infertility, its treatment or physician selection c

Published
2022

20. Maternal stress before and during pregnancy and subsequent infertility in daughters:a nationwide population-based cohort study

Author

Plana-Ripoll, O, Li, J, Kesmodel, U S, Olsen, J., Parner, E, Basso, O, Plana-Ripoll, O, Li, J, Kesmodel, U S, Olsen, J., Parner, E, and Basso, O

Abstract

STUDY QUESTION: Is maternal stress following the death of a close relative before or during pregnancy associated with the risk of infertility in daughters?SUMMARY ANSWER: Compared with unexposed women, women whose mothers had experienced bereavement stress during, or in the year before, pregnancy had a similar risk of infertility overall, but those exposed to maternal bereavement during the first trimester had a higher risk of infertility.WHAT IS KNOWN ALREADY: Animal studies have shown that prenatal maternal stress results in reduced offspring fertility. In humans, there is evidence that girls who have been prenatally exposed to stress have a more masculine behaviour and a slight delay in having their first child.STUDY DESIGN, SIZE AND DURATION: This population-based cohort study, included 660 099 females born in Denmark between 1 January 1973 and 31 December 1993 to mothers of Danish origin and with at least one living relative in the exposure window, and followed the women through 31 December 2011.PARTICIPANTS/MATERIALS, SETTING, METHODS: Overall, 13 334 women (2.0%) were considered prenatally exposed to stress because their mother had lost a spouse/partner, a child, a parent, or a sibling during pregnancy or in the year before conception. Infertility was defined as any record of infertility treatment or diagnosis of female infertility. We considered the date of onset as the date of the first appearance of any such record. The association between exposure and outcome was examined using hazard ratios (HR) with 95% confidence intervals (CI).MAIN RESULTS AND THE ROLE OF CHANCE: Based on our definition, 40 052 (6.5%) women were infertile in the follow-up period (median age at the end of follow-up: 26.7 years, maximum age: 39 years). Overall, prenatal exposure to maternal stress was not associated with risk of infertility (adjusted HR = 1.04 [CI: 0.95-1.14]). However, women prenatally exposed during the first trimester had a highe

Published
2016

23. Causal inference in studies of preterm babies: a simulation study.

Author

Snowden, J. M. and Basso, O.

Subjects
*PREMATURE labor, *SIMULATION methods & models, *COHORT analysis, *NEONATAL death, *GESTATIONAL age, *GENETICS, *COMPUTER simulation, *PREMATURE infants, *PREMATURE infant diseases, *INFANT mortality, *LONGITUDINAL method, *PREECLAMPSIA, *RESEARCH funding, *HEALTH self-care, *SELF-evaluation, *ODDS ratio
Abstract

Objective: Using a simple simulation, we illustrate why associations estimated from studies restricted to preterm births cannot be interpreted causally.Design, Setting and Population: Data simulation involving a hypothetical cohort of fetuses who may be healthy or have one or more of four pathological factors (termed A through D, increasing in severity) with known effects on gestational length and risk of mortality. We focus on babies born at ≤32 weeks of gestation.Methods: We visually represent the simulated population and compare the association between A (which may represent pre-eclampsia) and neonatal death. We then repeat the exercise with D (standing in for chorioamnionitis) as the exposure of interest.Main Outcome Measures: Odds ratios of neonatal death in the simulated data.Results: In most weeks, and for both A and D, the calculated odds ratios are substantially biased and underestimate the true risk of neonatal death associated with each pathology. For example, factor A has a true causal odds ratio of 1.50, yet it appears protective among births ≤32 weeks (estimated crude odds ratio 0.39; gestational age-adjusted odds ratio 0.71).Conclusions: Among very preterm births, virtually all babies are born with pathologies that increase the risk of adverse outcomes. Hence, babies exposed to one factor (e.g. pre-eclampsia) are compared with babies who have a mix of other pathologies. Such selection bias affects studies carried out among very preterm births (e.g. where pre-eclampsia appears to reduce risk of adverse neonatal outcomes).Tweetable Abstract: Selection bias affects studies of preterm births, complicating interpretation. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Sandler Environ Health Perspect: pesticide exposure and hypertensive disorders during pregnancy

Author

Saldana, T.M., Basso O., and Baird, D.D.

Subjects
Risk factors, Health aspects, Pesticides -- Health aspects, Agricultural pollution -- Risk factors, Pregnant women -- Health aspects, Gestational hypertension -- Risk factors, Hypertension in pregnancy -- Risk factors
Abstract

BACKGROUND: Hypertensive disorders of pregnancy, including pregnancy-induced hypertension (PIH) and preeclampsia (PE), complicate 2-8% of pregnancies. Few studies have examined environmental risk factors in relation to these conditions. OBJECTIVES: Our [...]

Published
2009

25. Understanding the impact of culture on firm's entrepreneurial orientation and behaviour: a conceptual framework

Author

Fayolle, A., Basso, O., Bouchard, V., Management, entrepreneuriat, innovation, Centre d'études et de recherches appliquées à la gestion (CERAG), Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF), and Lucatello, Coralie

Subjects
a conceptual framework, Understanding the impact of culture on firm's entrepreneurial orientation and behaviour, [SHS.GESTION]Humanities and Social Sciences/Business administration, [SHS.GESTION] Humanities and Social Sciences/Business administration
Published
2011

27. Corporate Entrepreneurship: Challenges and New Perspectives

Author

Fayolle, A., Basso, O., Bouchard, V., Management, entrepreneuriat, innovation, Centre d'études et de recherches appliquées à la gestion (CERAG), Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF), and Lucatello, Coralie

Subjects
Challenges and New Perspectives, [SHS.GESTION]Humanities and Social Sciences/Business administration, [SHS.GESTION] Humanities and Social Sciences/Business administration, Corporate Entrepreneurship
Published
2010

30. Allergic rhinitis and asthma comorbidity in a survey of young adults in Italy

Author

Bugiani, M., Carosso, A., Migliore, E., Piccioni, P., Corsico, A., Olivieri, M., Ferrari, M., Pirina, P., Marinoni, R. de Marco on behalf of ISAYA: Principal researchers: A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Colato, S., Moscato, G., Perfetti, L., Alesina, R., Basso, O., Berrayah, L., Brusotti, R., Fanfulla, F., Moi, P., Frati, C., Karytinos, P., Arossa, W., Caria, E., Castiglioni, G., Romano, Canzio, Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, P., Bono, Roberto, Gigli, G., Giraudo, A., Brussino, M. C., Bucca, Caterina, Rolla, Giovanni, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Sulotto, F., de Marco, R., Verlato, G., Accordini, S., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Biasin, C., Campello, C., Rossi, F., Cannistra`, A., Cenci, B., Destefani, E., Girotto, M., Lampronti, G., Martini, C., Tardivo, S., Villani, A., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., P. Natale, M. Grosa, Tacconi, A., Frontero, P., and Salomoni, A.

Published
2005

33. Is the prevalence of adult asthma and allergic rhinitis still increasing? Results of an Italian study

Author

Verlato, G, Corsico, A, Villani, S, Cerveri, I, Migliore, E, Accordini, S, Carolei, A, Piccioni, P, Bugiani, M, Lo Cascio, V, Marinoni, A, Poli, A, Ecrhs, de Marco R., Marinoni, ISAYA group Principal researchers: A., Carolei, A., Montomoli, C., Villani, S., Comelli, M., Ponzio, M., Grassi, M., Rezzani, C., Casali, L., Cerveri, I., Zoia, M. C., Corsico, A., Colato, S., Moscato, G., Perfetti, L., Alesina, R., Basso, O., Berrayah, L., Brusotti, R., Fanfulla, F., Moi, P., Frati, C., Karytinos, P., Bugiani, M., Piccioni, P., Carosso, A., Arossa, W., Caria, E., Castiglioni, G., Migliore, E., Romano, C., Fabbro, D., Ciccone, G., Magnani, C., Dalmasso, Paola, Bono, Roberto, Gigli, G., Giraudo, A., Brussino, Luisa, Bucca, Caterina, Rolla, Giovanni, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Sulotto, F., de Marco, R., Verlato, G., Accordini, S., Zanolin, M. E., Locatelli, F., Cazzoletti, L., Pattaro, C., Sartori, S., Poli, A., Dorigo, N., Cantarelli, S., Ciresola, D., Lo Cascio, V., Olivieri, M., Ferrari, M., Biasin, C., Campello, C., Rossi, F., Cannistrà, A., Cenci, B., Destefani, E., Girotto, M., Lampronti, G., Martini, C., Tardivo, S., Villani, A., Lauriola, P., Danielli, G., Sesti, D., Ghigli, E., Natale, P., Grosa, M., Tacconi, A., Frontero, P., and Salomoni, A.

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Allergy, Rhinitis, Allergic, Perennial, temporal trend, Immunology, Logistic regression, asthma, allergic rhinitis, temporal trend, epidemiology, Epidemiology, Prevalence, Immunology and Allergy, Medicine, Humans, Non-response bias, Young adult, Asthma, Response rate (survey), allergic rhinitis, business.industry, Rhinitis, Allergic, Seasonal, Odds ratio, asthma, medicine.disease, Italy, Female, epidemiology, business
Abstract

The prevalence of asthma and allergic rhinitis has increased worldwide during the 1970s and 1980s.This study was aimed at evaluating whether the increasing trend in prevalence persisted during the 1990s in the young adult Italian population.In 1998 to 2000 a screening questionnaire was sent by mail to a general population sample aged 20 to 44 years; nonresponders were contacted again first by mail and then by phone, achieving a final response rate of 78.1% (6876 of 8800). Prevalence estimates, adjusted to correct for nonresponse bias, were compared with those recorded in Italy in 1991 to 1993 during the European Community Respiratory Health Survey, when response rate had been slightly higher (87.6%). Temporal variations in symptom prevalence were analyzed by a logistic regression model, controlling for sex, age, site of residence (urban vs suburban areas), season of response, response rate, and type of contact (mail vs phone).The prevalence of asthma attacks did not vary significantly from 1991 to 1993 (3.6%) to 1998 to 2000 (3.2%) (P =.188). The prevalence of asthma-like symptoms (wheezing, chest tightness, shortness of breath) tended to decrease in the age classes of 32.5 to 45 years, while increasing in the youngest age class (20 to 26 years). A clear-cut increase from 15.4% to 18.3% was observed for the prevalence of allergic rhinitis (P.001), whereas the proportion of people under antiasthmatic treatment increased in suburban areas but not in urban areas (interaction time-site of residence, P.001).Asthma prevalence has not increased during the last decade in Italy. The persistence of an increasing trend in allergic rhinitis prevalence deserves attention.

Published
2003

34. Prevalence and features of allergic rhinitis in Italy

Author

Olivieri, M., Verlato, G., Corsico, A., Lo Cascio, V., Bugiani, M., Marinoni, A., de Marco, R., for the Italian ECRHS group: *Members of the European Community Respiratory Health Survey, Italy, de Marco, 1. 9. 9. 1. –. 1. 9. 9. 3. Universita` di Verona: R., Campello, C., Rossi, F., Biasin, C., Cannistra`, A., Cenci, B., Destefani, E., Ferrari, M., Girotto, M., Lampronti, G., Martini, C., Poli, A., Tardivo, S., Villani, A., Marinoni, M. E. Z. a. n. o. l. i. n. Universita` di Pavia: A., Cerveri, I., Alesina, R., Basso, O., Berrayah, L., Brusotti, . R., Fanfulla, F., Bucca, Caterina, Romano, Canzio, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Rolla, Giovanni, Casali*, F. S. u. l. o. t. t. o. USSL77 Pavia: L., Frati, C., Karytinos, P., Bugiani, ASL4 Torino: M., Arossa, . W., Caria, E., Carosso, A., Castiglioni, G., and principal investigators, P. P. i. c. c. i. o. n. i.

Subjects
allergic rhinitis
Published
2002

35. Fertility preservation in female cancer patients.

Author

Demeestere, Isabelle, Basso, O, Moffa, Federica, Peccatori, Fedro Alessandro, Poirot, C., Shalom-Paz, E., Demeestere, Isabelle, Basso, O, Moffa, Federica, Peccatori, Fedro Alessandro, Poirot, C., and Shalom-Paz, E.

Abstract

Journal Article, FLWIN, info:eu-repo/semantics/published

Published
2012

37. Determinants of bronchial responsiveness in the European Community Respiratory Health Survey in Italy: evidence of an independent role of atopy, total serum IgE levels, and asthma symptoms

Author

DE MARCO, Roberto, LO CASCIO, Vincenzo, Campello, Cesare, Ferrari, Marcello, Biasin, C, Cannistra, A, Cenci, Beatrice, Destefani, E, Girotto, M, Lampronti, Guido, Martini, Claudio, Olivieri, Mario, Poli, Albino, Tardivo, Stefano, Verlato, Giuseppe, Villani, A, Zanolin, Maria Elisabetta, Marinoni, A, Cerveri, I, Alesina, R, Basso, O, Berrayah, L, Brusotti, R, Fanfulla, F, Moi, P, Zoia, Mc, Bucca, V, Romano, C, Aime, M, Cerutti, A, Chiampo, F, Gallo, W, Rola, G, Sulotto, F, Casali, L, Fratti, C, Karytinos, P, Bugiani, M, Arossa, W, Caria, E, Carosso, A, Castiglioni, G, and Piccioni, P.

Subjects
Adult, Hypersensitivity, Immediate, Male, bronchial hyperresponsiveness, Dose-Response Relationship, Drug, airway caliber, asthma epidemiology, IgE levels, skin test reactivity, Immunology, Immunoglobulin E, Asthma, Italy, Antibody Specificity, Risk Factors, Immunology and Allergy, Humans, Methacholine Compounds, Female, Bronchial Hyperreactivity, Skin Tests
Abstract

The aim of the analysis was to test whether total serum IgE levels, specific serum IgE levels, and asthma symptoms are independent predictors of bronchial hyperresponsiveness (BHR), after controlling for known risk factors or potential confounders. The study was carried out on a sample of 875 young adults, 20-44 years old, who took part in the European Community Respiratory Health Survey in Italy. The subjects underwent a dose-response methacholine challenge test. We also measured airway caliber as the baseline FEV1 in absolute terms and as percentage of forced vital capacity (FVC); skin wheal response to 11 common environmental allergens; and total and specific serum IgE levels to mites, molds, pets, and respiratory symptoms by means of a standardized questionnaire. Atopy (positive skin prick test and/or positive specific IgE assay), total IgE, asthma symptoms, airway caliber, and age appeared to be independent predictors of BHR. When all the other risk factors were taken into account, atopy and total IgE were associated with a threefold increase in BHR risk and thus emerged as the main determinants of BHR. The importance of symptom status as a determinant of BHR decreased remarkably after controlling for atopy and IgE: the odds ratio of current asthmatics to asymptomatic subjects decreased from 15.3 to 8.8. When controlling for symptoms and atopy, a family history of allergic diseases and early respiratory infections was not found to be associated with BHR. Both FEV1 and FEV1/FVC were strongly and inversely associated with BHR. When airway caliber was taken into account, older age was associated with decreased responsiveness, and the level of responsiveness did not differ significantly between males and females and between smokers and nonsmokers. The results from this analysis indicate that at any given age, irrespective of sex and smoking habits, total serum IgE, specific IgE, airway caliber, and asthma symptoms are the main independent factors influencing the occurrence of BHR in a young adult sample.

Published
1998

38. Determinants of bronchial responsiveness in the European Community Respiratory Health Survey in Italy: evidence of an independent role of atopy, total serum IgE levels, and asthma symptoms

Author

de Mareo, European Community Respiratory Health Survey Italy University di Verona: R., Lo Cascio, V., Campello, C., Ferrari, M., Biasin, C., Cannistro, A., Cenci, B., Destefani, E., Girotto, M., Lampronti, G., Martini, C., Olivieri, M., Poli, A., Tardivo, S., Verlato, G., Villani, A., Zanolin, M. E., Marinoni, Universita di Pavia: A., Alesina, I. C. e. r. v. e. r. i. R., Basso, O., Zoia, L. B. e. r. r. a. y. a. h. R. B. r. u. s. o. t. t. i. F. F. a. n. f. u. l. l. a. P. M. o. i. M. C., Bucca, Caterina, Romano, Canzio, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Rolla, Giovanni, Casali, F. Sulotto: USSL 77 Pavia: L., Fratti, C., Bugiani, P. Karytinos: USSL 7 Torino: M., Arossa, W., Caria, E., Carosso, A., Castiglioni, G., and Piccioni, P.

Published
1998

39. Evaluation of methacholine dose-response curves by linear and exponential mathematical models: goodness-of-fit and validity of extrapolation

Author

Verlato, G., Cerveri, I., Villani, A., Pasquetto, M., Ferrari, M., Fanfulla, F., Zanolin, E., Rijcken, B., de Marco, R. de M. a. r. c. o. Università di Verona: R., Lo Cascio, V., Campello, C., Rossi, F., Biasin, C., Cannistrà, A., Cenci, B., Destefani, E., Girotto, M., Lampronti, G., Martini, C., Olivieri, M., Poli, A., Tardivo, S., Zanolin, M. E., Marinoni, Università di Pavia: A., Alesina, R., Basso, O., Berrayah, L., Brusotti, R., Moi, P., Zoia, M. C., Università di Torino, Bucca, Caterina, Romano, Canzio, Aime, M., Cerutti, A., Chiampo, F., Gallo, W., Rolla, Giovanni, Sulotto, F., Casali, USSL 77 Pavia: L., Frati, C., Karytinos, P., Bugiani, USSL 7 Torino: M., Arossa, W., Caria, E., Carosso, A., Castiglioni, G., and Piccioni, P.

Subjects
methacholine challenge, dose-response curve
Published
1996

42. Prevalence of asthma and asthma symptoms in a general population sample from northern Italy

Author

DE MARCO, Roberto, LO CASCIO, Vincenzo, Campello, Cesare, Rossi, F, Biasin, C, Cannistrà, A, Cenci, Beatrice, Destefani, E, Ferrari, Marcello, Girotto, M, Lampronti, Guido, Martini, Claudio, Olivieri, Mario, Poli, Albino, Tardivo, Stefano, Verlato, Giuseppe, Villani, A, Zanolin, Maria Elisabetta, Marinoni, A, Cerveri, I, Alesina, R, Basso, O, Berrayah, L, Brusotti, R, Fanfulla, F, Moi, P, Zoia, Mc, Bucca, C, Romano, C, Aime, M, Cerutti, A, Chiampo, F, Gallo, W, Rola, G, and Sulotto, F.

Subjects
asthma • asthma symptoms • epidemiology • prevalence
Published
1995

43. Prevalence of asthma and asthma symptoms in a general-population sample from northern italy

Author

Demarco, R, Locascio, V, Campello, C, Rossi, F, Biasin, C, Cannistra, A, Cenci, B, Destefani, E, Ferrari, M, Girotto, M, Lampronti, G, Martini, C, Olivieri, M, Poli, A, Tardivo, S, Verlato, G, Villani, A, Zanolin, Me, Marinoni, A, Cerveri, I, Alesina, R, Basso, O, Berrayah, L, Brusotti, R, Fanfulla, F, Moi, P, Zoia, Mc, Bucca, Caterina, Romano, Canzio, Aime, M, Cerutti, A, Chiampo, F, Gallo, W, Rola, G, Sulotto, F, Casali, L, Fratti, C, Karytinos, P, Bugiani, M, Arossa, W, Caria, E, Carosso, A, Castiglioni, G, Piccioni, P., and Rolla, Giovanni

Subjects
ASTHMA SYMPTOMS, ASTHMA, EPIDEMIOLOGY, PREVALENCE
Published
1995

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