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1. Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Author

Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Spinello, Antinori, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, de Jongh, Willem A., Salanti, Ali, Theander, Thor G., McCall, Matthew B.B., Esen, Meral, Van Coillie, Julie, Pongracz, Tamas, Šuštić, Tonći, Wang, Wenjun, Nouta, Jan, Le Gars, Mathieu, Keijzer, Sofie, Linty, Federica, Cristianawati, Olvi, Keijser, Jim B.D., Visser, Remco, Smit, Merel J., Sander, Adam, Schmidt, David E., Steenhuis, Maurice, Rispens, Theo, Nielsen, Morten A., Mordmüller, Benjamin G., Ellen van der Schoot, C., Roozendaal, Ramon, Wuhrer, Manfred, and Vidarsson, Gestur

Published
2023
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2. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

Author

Antinori, Spinello, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Van Coillie, Julie, Pongracz, Tamas, Rahmöller, Johann, Chen, Hung-Jen, Geyer, Chiara Elisabeth, Buhre, Jana Sophia, Šuštić, Tonći, van Osch, Thijs Luc Junior, Steenhuis, Maurice, Hoepel, Willianne, Wang, Wenjun, Lixenfeld, Anne Sophie, Nouta, Jan, Keijzer, Sofie, Linty, Federica, Visser, Remco, Larsen, Mads Delbo, Martin, Emily Lara, Künsting, Inga, Lehrian, Selina, von Kopylow, Vera, Kern, Carsten, Lunding, Hanna Bele, de Winther, Menno, Rispens, Theo, Graf, Tobias, Slim, Marleen Adriana, Minnaar, René Peter, Bomers, Marije Kristianne, Sikkens, Jonne Jochum, van der Schoot, C. Ellen, den Dunnen, Jeroen, Wuhrer, Manfred, Ehlers, Marc, and Vidarsson, Gestur

Published
2023
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3. Mortality among Italians and immigrants with COVID-19 hospitalised in Milan, Italy: data from the Luigi Sacco Hospital registry

Author

Giacomelli, Andrea, Ridolfo, Anna Lisa, Bonazzetti, Cecilia, Oreni, Letizia, Conti, Federico, Pezzati, Laura, Siano, Matteo, Bassoli, Cinzia, Casalini, Giacomo, Schiuma, Marco, Covizzi, Alice, Passerini, Matteo, Piscaglia, Marco, Borgonovo, Fabio, Galbiati, Claudia, Colombo, Riccardo, Catena, Emanuele, Rizzardini, Giuliano, Milazzo, Laura, Galli, Massimo, Brucato, Antonio, and Antinori, Spinello

Published
2022
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4. Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy

Author

Morena, Valentina, Milazzo, Laura, Oreni, Letizia, Bestetti, Giovanna, Fossali, Tommaso, Bassoli, Cinzia, Torre, Alessandro, Cossu, Maria Vittoria, Minari, Caterina, Ballone, Elisabetta, Perotti, Andrea, Mileto, Davide, Niero, Fosca, Merli, Stefania, Foschi, Antonella, Vimercati, Stefania, Rizzardini, Giuliano, Sollima, Salvatore, Bradanini, Lucia, Galimberti, Laura, Colombo, Riccardo, Micheli, Valeria, Negri, Cristina, Ridolfo, Anna Lisa, Meroni, Luca, Galli, Massimo, Antinori, Spinello, and Corbellino, Mario

Published
2020
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5. Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Author

Van Coillie, Julie, primary, Pongracz, Tamas, additional, Šuštić, Tonći, additional, Wang, Wenjun, additional, Nouta, Jan, additional, Le Gars, Mathieu, additional, Keijzer, Sofie, additional, Linty, Federica, additional, Cristianawati, Olvi, additional, Keijser, Jim B.D., additional, Visser, Remco, additional, van Vught, Lonneke A., additional, Slim, Marleen A., additional, van Mourik, Niels, additional, Smit, Merel J., additional, Sander, Adam, additional, Schmidt, David E., additional, Steenhuis, Maurice, additional, Rispens, Theo, additional, Nielsen, Morten A., additional, Mordmüller, Benjamin G., additional, Vlaar, Alexander P.J., additional, Ellen van der Schoot, C., additional, Roozendaal, Ramon, additional, Wuhrer, Manfred, additional, Vidarsson, Gestur, additional, Appelman, Brent, additional, van de Beek, Diederik, additional, Bomers, Marije K., additional, de Brabander, Justin, additional, Brouwer, Matthijs C., additional, Buis, David T.P., additional, Chekrouni, Nora, additional, van Gils, Marit J., additional, de Jong, Menno D., additional, Lavell, Ayesha H.A., additional, Olie, Sabine E., additional, Peters, Edgar J.G., additional, Reijnders, Tom D.Y., additional, Schinkel, Michiel, additional, Schuurman, Alex R., additional, Sikkens, Jonne J., additional, Smulders, Yvo M., additional, Wiersinga, Joost W., additional, Spinello, Antinori, additional, Bassoli, Cinzia, additional, Bestetti, Giovanna, additional, Corbellino, Mario, additional, Covizzi, Alice, additional, Lupo, Angelica, additional, Milazzo, Laura, additional, Schiuma, Marco, additional, Torre, Alessandro, additional, de Jongh, Willem A., additional, Salanti, Ali, additional, Theander, Thor G., additional, McCall, Matthew B.B., additional, and Esen, Meral, additional

Published
2023
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7. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

Author

Van Coillie, Julie, primary, Pongracz, Tamas, additional, Rahmöller, Johann, additional, Chen, Hung-Jen, additional, Geyer, Chiara Elisabeth, additional, van Vught, Lonneke A., additional, Buhre, Jana Sophia, additional, Šuštić, Tonći, additional, van Osch, Thijs Luc Junior, additional, Steenhuis, Maurice, additional, Hoepel, Willianne, additional, Wang, Wenjun, additional, Lixenfeld, Anne Sophie, additional, Nouta, Jan, additional, Keijzer, Sofie, additional, Linty, Federica, additional, Visser, Remco, additional, Larsen, Mads Delbo, additional, Martin, Emily Lara, additional, Künsting, Inga, additional, Lehrian, Selina, additional, von Kopylow, Vera, additional, Kern, Carsten, additional, Lunding, Hanna Bele, additional, de Winther, Menno, additional, van Mourik, Niels, additional, Rispens, Theo, additional, Graf, Tobias, additional, Slim, Marleen Adriana, additional, Minnaar, René Peter, additional, Bomers, Marije Kristianne, additional, Sikkens, Jonne Jochum, additional, Vlaar, Alexander P.J., additional, van der Schoot, C. Ellen, additional, den Dunnen, Jeroen, additional, Wuhrer, Manfred, additional, Ehlers, Marc, additional, Vidarsson, Gestur, additional, Antinori, Spinello, additional, Bassoli, Cinzia, additional, Bestetti, Giovanna, additional, Corbellino, Mario, additional, Covizzi, Alice, additional, Lupo, Angelica, additional, Milazzo, Laura, additional, Schiuma, Marco, additional, Torre, Alessandro, additional, Appelman, Brent, additional, van de Beek, Diederik, additional, Bomers, Marije K., additional, de Brabander, Justin, additional, Brouwer, Matthijs C., additional, Buis, David T.P., additional, Chekrouni, Nora, additional, van Gils, Marit J., additional, de Jong, Menno D., additional, Lavell, Ayesha H.A., additional, Olie, Sabine E., additional, Peters, Edgar J.G., additional, Reijnders, Tom D.Y., additional, Schinkel, Michiel, additional, Schuurman, Alex R., additional, Sikkens, Jonne J., additional, Slim, Marleen A., additional, Smulders, Yvo M., additional, and Wiersinga, Joost W., additional

Published
2023
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8. Rapid lateral-flow immunochromatographic tests to assess anti N/S IgG seropositivity after BNT162b2 vaccine: A cross-sectional study

Author

Pezzati, Laura, primary, Giacomelli, Andrea, additional, Mileto, Davide, additional, Conti, Federico, additional, Gagliardi, Gloria, additional, Rizzo, Alberto, additional, Milazzo, Laura, additional, Schiuma, Marco, additional, Covizzi, Alice, additional, Siano, Matteo, additional, Bassoli, Cinzia, additional, Passerini, Matteo, additional, Piscaglia, Marco, additional, Torre, Alessandro, additional, Oreni, Letizia, additional, Rizzardini, Giuliano, additional, Galli, Massimo, additional, Ridolfo, Anna Lisa, additional, and Antinori, Spinello, additional

Published
2021
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10. High Mortality Rate Among Latin American Immigrants With Covid-19 Hospitalised in Milan, Italy: Data From the Luigi Sacco Hospital Registry

Author

Giacomelli, Andrea, primary, Ridolfo, Anna Lisa, additional, Bonazzetti, Cecilia, additional, Oreni, Letizia, additional, Conti, Federico, additional, Pezzati, Laura, additional, Siano, Matteo, additional, Bassoli, Cinzia, additional, Casalini, Giacomo, additional, Schiuma, Marco, additional, Covizzi, Alice, additional, Passerini, Matteo, additional, Piscaglia, Marco, additional, Borgonovo, Fabio, additional, Galbiati, Claudia, additional, Colombo, Riccardo, additional, Catena, Emanuele, additional, Rizzardini, Giuliano, additional, Milazzo, Laura, additional, Galli, Massimo, additional, Brucato, Antonio, additional, and Antinori, Spinello, additional

Published
2021
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12. Early administration of lopinavir/ritonavir plus hydroxychloroquine does not alter the clinical course of SARS‐CoV‐2 infection: A retrospective cohort study

Author

Giacomelli, Andrea, primary, Pagani, Gabriele, additional, Ridolfo, Anna L., additional, Oreni, Letizia, additional, Conti, Federico, additional, Pezzati, Laura, additional, Bradanini, Lucia, additional, Casalini, Giacomo, additional, Bassoli, Cinzia, additional, Morena, Valentina, additional, Passerini, Simone, additional, Rizzardini, Giuliano, additional, Cogliati, Chiara, additional, Ceriani, Elisa, additional, Colombo, Riccardo, additional, Rusconi, Stefano, additional, Gervasoni, Cristina, additional, Cattaneo, Dario, additional, Antinori, Spinello, additional, and Galli, Massimo, additional

Published
2020
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14. Role of serum albumin and proteinuria in patients with SARS‐CoV‐2 pneumonia.

Author

Bassoli, Cinzia, Oreni, Letizia, Ballone, Elisabetta, Foschi, Antonella, Perotti, Andrea, Mainini, Annalisa, Casalini, Giacomo, Galimberti, Laura, Meroni, Luca, Antinori, Spinello, and Milazzo, Laura

Abstract

Background: Hypoalbuminemia is frequently observed in patients with SARS‐CoV‐2 infection although its underlying mechanism and relationship with the clinical outcome still need to be clarified. Methods: We retrospectively evaluated in patients with COVID‐19 hospitalised at the Fatebenefratelli‐Sacco Hospital in Milan, the prevalence of hypoalbuminemia, its association with the severity of COVID‐19, with the levels of C‐reactive protein, d‐dimer and interleukin‐6 and with clinical outcome over a follow‐up period of 30 days. Urinalysis was evaluated in a subgroup of patients. Results: Serum albumin levels <30 g/L were found in 105/207 (50.7%) patients at hospital admission. Overall, the median albumin value was 29.5 g/L (IQR 25‐32.8). A negative association was found between albumin levels and severity of COVID‐19 (P <.0001) and death (P =.003). An inverse correlation was observed between albumin and both C‐reactive protein and D‐dimer at hospital admission (r = −.487 and r = −.479, respectively; P <.0001). Finally, a positive correlation was found between albumin levels and eGFR (r =.137; P =.049). Proteinuria was observed in 75% of patients with available data and it did not differ between patients with hypoalbuminemia and those with albumin ≥30 g/L (81% and 67%, respectively; P =.09). Conclusion: In patients with COVID‐19, hypoalbuminemia is common and observed in quite an early stage of pulmonary disease. It is strictly associated with inflammation markers and clinical outcome. The common finding of proteinuria, even in the absence of creatinine increase, indicates protein loss as a possible biomarker of local and systemic inflammation worthwhile to evaluate disease severity in COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Early administration of lopinavir/ritonavir plus hydroxychloroquine does not alter the clinical course of SARS‐CoV‐2 infection: A retrospective cohort study.

Author

Giacomelli, Andrea, Pagani, Gabriele, Ridolfo, Anna L., Oreni, Letizia, Conti, Federico, Pezzati, Laura, Bradanini, Lucia, Casalini, Giacomo, Bassoli, Cinzia, Morena, Valentina, Passerini, Simone, Rizzardini, Giuliano, Cogliati, Chiara, Ceriani, Elisa, Colombo, Riccardo, Rusconi, Stefano, Gervasoni, Cristina, Cattaneo, Dario, Antinori, Spinello, and Galli, Massimo

Subjects
SARS-CoV-2, HYDROXYCHLOROQUINE, RITONAVIR, COVID-19, COHORT analysis
Abstract

As it has been shown that lopinavir (LPV) and hydroxychloroquine (HCQ) have in vitro activity against coronaviruses, they were used to treat COVID‐19 during the first wave of the epidemic in Lombardy, Italy. To compare the rate of clinical improvement between those who started LPV/ritonavir (LPV/r)+HCQ within 5 days of symptom onset (early treatment, ET) and those who started later (delayed treatment, DT). This was a retrospective intent‐to‐treat analysis of the hospitalized patients who started LPV/r + HCQ between 21 February and 20 March 2020. The association between the timing of treatment and the probability of 30‐day mortality was assessed using univariable and multivariable logistic models. The study involved 172 patients: 43 (25%) in the ET and 129 (75%) in the DT group. The rate of clinical improvement increased over time to 73.3% on day 30, without any significant difference between the two groups (Gray's test P =.213). After adjusting for potentially relevant clinical variables, there was no significant association between the timing of the start of treatment and the probability of 30‐day mortality (adjusted odds ratio [aOR] ET vs DT = 1.45, 95% confidence interval 0.50‐4.19). Eight percent of the patients discontinued the treatment becausebecause of severe gastrointestinal disorders attributable to LPV/r. The timing of the start of LPV/r + HCQ treatment does not seem to affect the clinical course of hospitalized patients with COVID‐19. Together with the severe adverse events attributable to LPV/r, this raises concerns about the benefit of using this combination to treat COVID‐19. Highlights: Lopinavir/ritonavir (LPV/r) plus hydroxychloroquine (HCQ) have been repurposed to treat COVID‐19.We studied the combination of LPV/r plus HCQ in 172 hospitalised patients with COVID‐19.Early LPV/r plus HCQ treatment was not associated with a faster improvement in the patients clinical condition.Early LPV/r plus HCQ treatment did not reduce 30‐day mortality.Eight percent of the patients discontinued the treatment due to severe adverse events. [ABSTRACT FROM AUTHOR]

Published
2021
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16. THU0289 PERSISTENCE OF CIRCULATING CRYOGLOBULINS AND RELATED SYMPTOMS AFTER HEPATITIS C VIRUS ERADICATION IN PATIENTS WITH MIXED CRYOGLOBULIN SYNDROME

Author

Bassoli, Cinzia Roberta, primary, Oreni, Letizia, additional, Sollima, Salvatore, additional, Saccardo, Francesco, additional, Sebastiani, Marco, additional, Vacchi, Caterina, additional, Mazzaro, Cesare, additional, Zani, Roberta, additional, Ferri, Clodoveo, additional, Zignego, Anna Linda, additional, Monti, Giuseppe, additional, Brancaccio, Giuseppina, additional, Gentile, Ivan, additional, Masarone, Mario, additional, Gabiati, Claudia, additional, Pontali, Emanuele, additional, Castelnovo, Laura, additional, Messina, Vincenzo, additional, and Galli, Massimo, additional

Published
2019
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19. Legionellosis Complicated by Invasive Aspergillosis in a Patient With Rheumatoid Arthritis.

Author

Giacomelli A, Bassoli C, Corbellino M, Corona A, Colombo R, Borghi B, Rimoldi SG, Pagani C, Galli M, and Antinori S

Subjects
Humans, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid drug therapy, Aspergillosis complications, Legionellosis complications, Legionellosis diagnosis
Abstract

Competing Interests: The authors declare no conflict of interest.

Published
2021
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20. A case of crusted scabies with a delayed diagnosis and inadequate therapy.

Author

Bonazzetti C, Pagani G, Giacomelli A, Morena V, Bassoli C, Corbellino M, Bestetti G, Galimberti L, Grande R, and Antinori S

Subjects
Aged, 80 and over, Delayed Diagnosis, Diagnosis, Differential, Diagnostic Errors, Humans, Male, Medication Errors, Scabies diagnosis, Scabies drug therapy
Abstract

Crusted scabies is an infrequent disease caused by Sarcoptes scabiei that usually affects patients with underlying medical conditions leading to immunosuppression. Here, we present the case of an 81 years old man, diagnosed with crusted scabies who came to our attention after multiple misdiagnosis and incorrect and potentially detrimental treatment with steroids. He was admitted to our inpatients ward and treated with oral ivermectin plus local permethrin. The hospitalization was complicated by a secondary bacterial skin infection caused by methicillin-sensitive Staphylococcus aureus. Crusted scabies is commonly misdiagnosed in elderly and immunosuppressed people due to its unusual occurrence and atypical clinical presentation. It should be considered in the differential diagnosis of skin lesions associated with pruritus in patients with underling medical conditions leading to immunosuppression. A prompt diagnosis and treatment are warranted due to the potential secondary infections and subsequent related morbidity and mortality.

Published
2020

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