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1. Pharmacological Properties of Four Plant Species of the Genus Anabasis, Amaranthaceae

Author

Zhanybek Shegebayev, Aknur Turgumbayeva, Ubaidilla Datkhayev, Kairat Zhakipbekov, Assem Kalykova, Elmira Kartbayeva, Ahmet Beyatli, Kuanysh Tastambek, Gulmira Altynbayeva, Bassymbek Dilbarkhanov, Aiman Akhelova, Rabiga Anarbayeva, and Kulpan Orynbassarova

Subjects
Anabasis, Amaranthaceae, traditional use, pharmacological properties, antioxidant, Organic chemistry, QD241-441
Abstract

The genus Anabasis is a member of the family Amaranthaceae (former name: Chenopodiaceae) and includes approximately 102 genera and 1400 species. The genus Anabasis is one of the most significant families in salt marshes, semi-deserts, and other harsh environments. They are also renowned for their abundance in bioactive compounds, including sesquiterpenes, diterpenes, triterpenes, saponins, phenolic acids, flavonoids, and betalain pigments. Since ancient times, these plants have been used to treat various diseases of the gastrointestinal tract, diabetes, hypertension, and cardiovascular diseases and are used as an antirheumatic and diuretic. At the same time, the genus Anabasis is very rich in biologically active secondary metabolites that exhibit great pharmacological properties such as antioxidant, antibacterial, antiangiogenic, antiulcer, hypoglycemic, hepatoprotective, antidiabetic, etc. All of the listed pharmacological activities have been studied in practice by scientists from different countries and are presented in this review article to familiarize the entire scientific community with the results of these studies, as well as to explore the possibilities of using four plant species of the genus Anabasis as medicinal raw materials and developing medicines based on them.

Published
2023
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2. Periodontal status and bone metabolism in women in reproductive and postmenopausal periods

Author

Iryna Suprunovych, Iryna Mazur, Volodymyr Novoshytskyy, Bassymbek Dilbarkhanov, Xeniya Kuracha, and Kairat Zhakipbekov

Subjects
Adult, Aging, Endocrinology, Diabetes and Metabolism, Osteoporosis, Osteocalcin, Alveolar Bone Loss, Physiology, Mandible, Bone tissue, Bone remodeling, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, N-terminal telopeptide, medicine, Maxilla, Humans, Molecular Biology, Dental alveolus, Aged, Periodontitis, 030219 obstetrics & reproductive medicine, biology, business.industry, 030206 dentistry, General Medicine, Middle Aged, medicine.disease, Chronic periodontitis, Postmenopause, medicine.anatomical_structure, biology.protein, Female, Bone Remodeling, Collagen, business, Biomarkers
Abstract

Objectives Chronic periodontitis is one of the most common diseases in the world. Periodontitis occurs more frequently in postmenopausal women due to hormonal changes and in patients with osteoporosis. Thus, the aim of our study was to compare levels of alveolar bone loss of mandible and maxilla and bone tissue remodeling markers in women of reproductive and postmenopausal periods. Methods Fifty-nine women aged 25–68 years were enrolled in a cross-sectional study and divided into two groups. Group I consisted of 42 women of reproductive age and Group II included 17 women in their postmenopausal period. The level of alveolar bone loss of mandible and maxilla was assessed using dental panoramic radiography, and the level of bone remodeling markers (Beta C-terminal telopeptide of type I collagen [β-CTx] and osteocalcin) was obtained in both groups. Results Women in the postmenopausal period have higher level of alveolar bone loss in mandible and maxilla than women of reproductive age. The level of ß-CTx and osteocalcin was significantly higher in Group II, compared to Group I (p=0.002 and p=0.005, respectively). Conclusions In postmenopausal women, on the background of significantly higher bone remodeling, an increase of alveolar bone loss of mandible and maxilla was observed.

Published
2020

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