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1. Influence of age and self-stigmatization on social eating and drinking issues in French outpatients living with and beyond head and neck cancer: a mixed-method study

Author

Beauplet, Bérengère, Francois, Bianca, Bastit, Vianney, Lequesne, Justine, Rambeau, Audrey, Basti, Samira, Gery, Bernard, Larnaudie, Audrey, Lasne-Cardon, Audrey, Roussel, Lise-Marie, Veresezan, Ovidiu, Jean, Clément Petit, Chatelier, Anne, Ambroise, Beatrice, Veyssiere, Alexis, Bellefqih, Sara, Thureau, Sébastien, Levitchi, Mihai, Obongo-Anga, Franchel Raïs, Babin, Emmanuel, Dornan, Mark, Mange, Jessica, and Humbert, Maxime

Published
2024
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4. ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies

Author

Perréard, Marion, Florent, Romane, Divoux, Jordane, Grellard, Jean-Michel, Lequesne, Justine, Briand, Mélanie, Clarisse, Bénédicte, Rousseau, Nathalie, Lebreton, Esther, Dubois, Brice, Harter, Valentin, Lasne-Cardon, Audrey, Drouet, Julien, Johnson, Alisson, Le Page, Anne-Laure, Bazille, Céline, Jeanne, Corinne, Figeac, Martin, Goardon, Nicolas, Vaur, Dominique, Micault, Emmanuel, Humbert, Maxime, Thariat, Juliette, Babin, Emmanuel, Poulain, Laurent, Weiswald, Louis-Bastien, and Bastit, Vianney

Published
2023
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5. Survival outcomes, prognostic factors, and effect of adjuvant radiotherapy and prophylactic neck dissection in salivary acinic cell carcinoma: A prospective multicenter REFCOR study of 187 patients

Author

Chatelet, Florian, Ferrand, François Régis, Atallah, Sarah, Thariat, Juliette, Mouawad, François, Fakhry, Nicolas, Malard, Olivier, Even, Caroline, de Monès, Erwan, Uro-Coste, Emmanuelle, Benzerdjeb, Nazim, Hans, Stéphane, Testelin, Sylvie, Mauvais, Olivier, Evrard, Diane, Bastit, Vianney, Salas, Sébastien, Espitalier, Florent, Classe, Marion, Digue, Laurence, Doré, Mélanie, Wong, Stéphanie, Dupin, Charles, Nguyen, France, Bettoni, Jeremie, Lapierre, Ariane, Colin, Emilien, Philouze, Pierre, Vergez, Sébastien, Baujat, Bertrand, Herman, Philippe, and Verillaud, Benjamin

Published
2023
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6. Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19)

Author

Moulin, Solenne, Leleu, Olivier, Leparree, Sylvie, Goasdoue, Henri, Piprot, Christine, Tourneur, Gerald, Bayart, Vincent, Lignier, Delphine, Lachaier, Emma, Khamari, Marwa, Coutte, Alexandre, Siembida, Nicolas, Houessinon, Aline, Regimbeau, Jean Marc, Chauffert, Bruno, Moreira, Aurélie, Hautefeuille, Vincent, Hee, Christine, Boone, Mathieu, Bihan, Céline, Chive, Emilie, Poulet-Potriquier, Stéphane, Fahem, Rachida, Luet, Dominique, Roquin, Guillaume, Vitellius, Carole, Cornet-Trichereau, Nathanaëlle, Caroli-Bosc, François-Xavier, Thirot-Bidault, Anne, Ropert, Stanislas, Gachet - Masson, Julie, Dehais, Mélanie, L'helgoualc'h, Gwen-Ael, Ali-Mahamadou, Ibrahim, Talfi, Safia, Belmont, Laure, Kilendo, Dieudonné, Benrezzak, Nasro, Dubief, Emeline, Conroy, Guillaume, Delique, Laurence, Basso, Maud, Pons, Isabelle, Salignon, Karine, Villing, Anne-Laure, Mougenot, Emmanuelle, Porebski, Cassandra, Guiatni, Asma, Cloarec, Nicolas, Mineur, Laurent, Bouchaud, Marie, David, Céleste, Peytier, Annie, Greletty, Thomas, Audemar, Franck, Vignes, Emanuelle, Minne, Floriane, Goldzak, Guillaume, Huysman, Fabienne, Hocine, Fayçal, Lakkis, Zaher, Mansi, Laura, Meynard, Guillaume, Almotlak, Hamadi, Klajer, Elodie, Sun, Xu-Shan, Wasselin, Julie, Catala, Pascale, Mazuy, Claire, Vandamme, Hélène, Prevost, Jean-Briac, Fadin, Aurélie, Basson, Laurent, Huguet, Jean-Baptiste, Dos Santos, Emmanuelle, Jany, Bérangère, Saad, Alain, Goutorbe, Frédéric, Oziol, Eric, Ramdani, Mohamed, Kadiri, Ouafae, Garbay, Delphine, Huet, Clotilde, Giroux Leprieur, Etienne, Teng, Wen, Monvoisin, Justine, Arnaud Coffin, Patrick, Roux, Sylvie, Orfeuvre, Hubert, Chagros, Mélanie, Pillon, Didier, Rassoul, Agathe, Poureau, Pierre Guillaume, Novello, Cécile, Ducray, François, Trouba, Cécile, Bastit, Vianney, Babin, Emmanuel, Thariat, Juliette, Leon, Vincent, Courtecuisse, Anne-Catherine, Vambre, Julie, Tack, Vincent, Desauw, Christophe, Meniai, Fatima, Peres, Christina, Esparcieux, Aurélie, Perrier, Hervé, Doux, Nathalie, Kaphan, Régis, Roques, Bertrand, Rebischung, Christine, Mille, Dominique, Fernandes, Gaëlle, Abdelli, Naceur, Jousset, Natacha, Combe, Pierre, Jonveaux, Eric, Dumont, Patrick, Kanaan, Marc, Berthelot Gras, Corinne, Panis, Valérie, Kaluzinski, Laure, Venant-Valery, Marjolène, Lam, You-Heng, Vallee, Laura, Riviere, Frédéric, Durand, Muriel, Benghadid, Dihya, Villeneuve, Emilie, Hentic Dhome, Olivia, Laurent, Lucie, Bounouar, Zedjiga, De Mestier, Louis, Dubois, Jacqueline, Eyriey, Magali, Moreau, Lionel, Ahle, Guido, Baihas, Dib, Aldabbagh, Kaïs, Degriffolet, Dominique, Sebbagh, Virginie, Seghezzi, Jean-Christophe, Lozach-Brugirard, Marion, Mandrou, Julie, Mavier, Loubna, Hennetier, Florence, Wagner, Jean-Philippe, Carola, Elisabeth, Chandirakumaran, Karthiga, Loutski, Sandrine, Cojean-Zelek, Isabelle, Bouras, Amina, Lacour, Sandrine, Froura, Fahem, Ben Nadji, Hadjer, Cattelain, Sophie, Darloy, Franck, Jolimoy Boilleau, Geneviève, Maissiat, Cyrielle, Darut-Jouve, Ariane, Lorgis, Véronique, Charifi-Alaoui, Ikram, Ghiringhelli, François, Drouillard, Antoine, Chaix, Marie, Manfredi, Sylvain, Lepage, Côme, Gagnaire, Alice, Latournerie, Marianne, jourdan, Sofia, Perrot, Nora, folia, Mireille, Minello, Anne, Jouve, Jean-Louis, Fery, Marielle, Landau, Alain, Evrard, Diane, Valenza, Bruno, Paitel, Jean-François, Chablais, Laetitia, Kreitmann, Thomas, Lancry-Lecomte, Laurence, Monard, Adrien, Faugeras, Eve, Boucheret, Paul, Glommeau, Cécile, Tchikladze, Christine, Garnier Tixidre, Claire, Long, Jérôme, Zaidi, Manel, Delabarre, Véronique, Meyzenc, Juliette, Ferrand, Loïc, Moro-Sibilot, Denis, Bouheret, Paul, Leyronnas, Cécile, Herve, Camille, Thoor, Audrey, Jacquet, Emanuelle, Roth, Gaël, Madapathage-Senanyake, Videsheka, Chupeau, Peggy, Bieber, Elsa, Rosso, Maud, Lepage, Isabelle, Priou, Frank, Laly, Margot, Aprelon, Sylvie, Sobolak, Natacha, Homokos, Helen, Pointreau, Yoann, Watelle, Fabienne, Pham-Becker, Alice, Lauridant, Géraldine, Turpin, Anthony, Dujardin, Charlotte, Lenglin, Etienne, Nienguet Tsota, Aimée, Dominguez, Sophie, Forestier, Alexandra, Nouvel, Franck, Lerooy, Justine, Ratajczak, Céline, Romano, Olivier, Brzyski, Dorothéee, Barriere, Aurélien, Genet, Dominique, Tisse, Julien, Zasadny, Xavier, Grelet, Adeline, Hennion-Imbault, Amélie, Haustraete, Eglantine, Louafi, Samy, Awad, Manal, Zekri, Younes, Cheneau, Caroline, Leissen, Nolwen, Egreteau, Joëlle, Breant, Alexandra, Sarabi, Matthieu, Labonne, Stéphanie, Forestier, Julien, Leclercq, Céline, Prunier-Bossion, Florence, Ray Coquard, Isabelle, Guillet, Marielle, Theillaumas, Aurélie, Prome, Emilie, Walter, Thomas, Philouze, Pierre, Lawo, Melody, De Talhouet, Solène, Beuvelot, Johanne, Molin, Yann, Bellecoste Martin, Marie, Saussereau, Maud, Agnelli, Lauren, Fakhry, Nicolas, Laplace, Christophe, Norguet Monnereau, Emmanuelle, Boucard, Céline, Djenad, Kahina, Fontaine, Catherine, Seitz, Jean-François, Dahan, Laétitia, Sigrand, Julie, Duluc, Muriel, Locher, Christophe, Fleury, Marjory, Brou Marie, Ange, Berkane, Ramdane, Poupblanc, Séverine, Auby, Dominique, Petran, Daniela, Texereau, Patrick, Guerineau, Elodie, Andre, Morgan, Mahjoubi, Linda, Sarrazin, Fanny, Jeanson, Sonia, Gschwend, Anthony, Birr, Virginie, Debieuvre, Didier, Fore, Mathieu, Noirclerc, Monique, Dahou, Sihem, Spaeth, Dominique, Lambotin, Mélanie, Lelu, Thomas, Linot, Benjamin, Hugon, Nathalie, Rousseau, Dominique, Castanie, Hélène, Lenne, Carole, Lortholary, Alain, Cessot, Anatole, Merzoug, Messaouda, Naudin, Cécile, Vannetzel, Jean-Michel, Aziz, Ghina, Hadj Arab, Yacine, Pernes, Stéphanie, Roche-Lachaise, Isabelle, Fiteni, Frédéric, Yahiaoui, Hadjer, Marel Lopez, Gwendoline, Oddoz, Jeanne, Peira, Fabienne, Michel, Olivier, Meunier, Jérôme, Ouahrani, Brahim, Roger, Antoine, Branco, Sonia, Nguyen, Van, Gisselbrecht, Mathilde, Hammad, Ghania, Mordant, Pierre, Stroksztejn, Magda, Pocard, Marc, Nlo Meyengue, Luc, Aparicio, Thomas, Sacco, Emmanuelle, Simon Anne, Sophie, Fabre-Guillevin, Elizabeth, Wislez, Marie, Slim, Marine, Zaanan, Aziz, Cadranel, Jacques, Pluvy, Johan, Ursu, Rénata, Geraldo, Amyrath, Lihi, Rime, Vo, Maryline, Brouk, Zohra, Colle, Raphaël, Bennamoun, Mostefa, Lacan, Fabrice, Louvet, Christophe, Mebarki, Soraya, Veyri, Marianne, Paillaud, Elena, Lucas, Christelle, Dubreuil, Olivier, Lyamani, Jamila, Idbaih, Ahmed, Agguini, Hanane, Soularue, Emilie, Canellas, Anthony, Zalcman, Gérard, Jourdaine, Clément, Verillaud, Benjamin, Herzine, Hakima, Raymond, Eric, Mathiot, Nathalie, Palmieri, Lola Jade, Epanya, Christian, Taieb, Julien, Bertrand, Eliane, Goujon, Gaël, Namour, Céline, Gazeau, Benoit, Zafirova, Biljana, Mirghani, Haitham, Belin, Catherine, Belkhir, Kahina, Gharib, Myriam, Vozy, Aurore, Amrane, Karim, Spano, Jean-Philippe, Wassermann, Johanna, Feuvret, Loic, Bachet, Jean-Baptiste, Philonenko, Sara, Guillot, Laetitia, Zabbe, Marion, Gibiat, Stéphanie, Baylot, Camille, Jouinot, Aude, Leduc, Nicolas, Vieillot, Sabine, James, Laurie, Ducerf, Camille, Blanc, Jean-Frédéric, Falandry Leger, Claire, Wautot, Virginie, Chauvenet, Marion, Vincent, Aude, Tougeron, David, Goulvent, Sandrine, Suc, Etienne, Laurenty, Anne-Pascale, Marquis, Eric, Bonnaire, Margaux, Dewolf, Maxime, Brenet, Esteban, Billard, Delphine, Litre, Claude-Fabien, Dumazet, Antoine, Botsen, Damien, Vazel, Marion, Carlier, Claire, Bonnerave, David, Marchand-Crety, Charles, Bouche, Olivier, Fosse, Patricia, Sefrioui, David, Michel, Pierre, Watson, Sarah, Neuzillet, Cindy, Torche, Fatah, Muron, Thierry, Natur, Stéphane, Desgrippes, Romain, Bihel, Véronique, Ferrand, François-Régis, Leiterer, Caroline, Lavole, Julie, Moquet, Claire, Pressoir, Nathalie, Dziukala, Catherine, Ligeza Poisson, Catherine, Naji, Abdelhalim, Williet, Nicolas, Phelip, Jean-Marc, Di Palma, Fabrice, Kherrour Mehdi, Amina, Langrand-Escure, Julien, Fournel, Pierre, Pigne, Grégoire, Saban-Roche, Léa, Magne, Nicolas, Vassal, Cécile, Jacquin, Jean-Philippe, Ramirez, Carole, Vallard, Alexis, Collard, Olivier, Rivoirard, Romain, Graber, Ivan, Trager Maury, Stéphanie, Duboisset, Elodie, Ayllon Ugarte, Jorge, Rami, Dalilia, Saler, Christine, Reinbolt, Manon, Le Fevre, Clara, Ben Abdelghani, Meher, Dourthe, Louis-Marie, Perruisseau-Carrier, Joffrey, Nguimpi-Tambou, Marlène, Barret, Flavie, Di Stefano Anna, Luisa, Balthazard, Annie, Mabro, May, Vassord-Dang, Camille, Le Marchand, Mathilde, Vergniol, Julien, Pripon, Iulia, Daemaegdt, Axelle, Latry, Vanessa, Larrieu, Muna, Landry, Gaëlle, Touihri Maximin, Laetitia, Del Piano, Francesco, Barlet, Agnès, Vernisse, Mylène, Lafond, Sophie, Genin, Charline, Sibertin-Blanc, Camille, Chabrillac, Emilien, Gregoire, Caroline, Vergez, Sébastien, Panouille, Quentin, Guimbaud, Rosine, Richa, Floriane, Lebellec, Loïc, Gounin, Sophie, Buiret, Guillaume, Baudin, Marine, Hamon, Hervé, Deshorgue, Anne-Claire, Barrascout, Eduardo, Legrand, Stéphanie, Houlze, Morgane, Cambula, Linda, Lopez, Anthony, Fouquet, Guillaume, Touabi, Kahina, GermaIn, Adeline, Godbert, Benoit, Voivret, Florence, Perrin, Julie, Da Silva, Rosa, Bernichon, Emilie, Lièvre, Astrid, Ray-Coquard, Isabelle, Le Malicot, Karine, Paoletti, Xavier, Bouché, Olivier, Aldabbagh, Kais, Colle, Raphael, Hardy-Bessard, Anne-Claire, Colomba, Emeline, Bourhis, Jean, Gorphe, Philippe, Ursu, Renata, and Di Stefano, Anna Luisa

Published
2020
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8. Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Author

Atallah, Sarah, Moya-Plana, Antoine, Malard, Olivier, Poissonnet, Gilles, Fakhry, Nicolas, Bettoni, Jérémie, Gallet, Patrice, Ransy, Pierre, Vergez, Sebastien, De Gabory, Ludovic, Evrard, Diane, Lesnik, Maria, Philouze, Pierre, Bertolus, Chloé, Schultz, Philippe, Morinière, Sylvain, Bastit, Vianney, Righini, Christian A., Mirghani, Haitham, Jegoux, Franck, Mauvais, Olivier, Biau, Julian, Dufour, Xavier, Bon-Mardion, Nicolas, Brenet, Esteban, Verillaud, Benjamin, and Baujat, Bertrand

Published
2020
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9. First-line F18-choline PET/CT Versus Tc99m-sestaMIBI SPECT/CT in the surgical management of primary hyperparathyroidism: a diagnostic randomized phase III trial

Author

Quak, Elske, primary, Lasne-Cardon, Audrey, additional, Cavarec, Marie-Beatrice, additional, Lireux, Barbara, additional, Bastit, Vianney, additional, Roudaut, Nathalie, additional, Salaun, Pierre-Yves, additional, Keromnes, Nathalie, additional, Potard, Gael, additional, Vaduva, Patricia, additional, Esvant, Annabelle, additional, Jegoux, Franck, additional, De, Crouy-Chanel Olivier, additional, Devillers, Anne, additional, Guery, Clemence, additional, Christy, Francois, additional, Grellard, Jean-Michel, additional, Bardet, Stephane, additional, and Clarisse, Benedicte, additional

Published
2024
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11. F18-Choline PET/CT or MIBI SPECT/CT in the Surgical Management of Primary Hyperparathyroidism: A Diagnostic Randomized Clinical Trial.

Author

Quak, Elske, Lasne-Cardon, Audrey, Cavarec, Marie, Lireux, Barbara, Bastit, Vianney, Roudaut, Nathalie, Salaun, Pierre-Yves, Keromnes, Nathalie, Potard, Gaël, Vaduva, Patricia, Esvant, Annabelle, Jegoux, Franck, de Crouy-Chanel, Olivier, Devillers, Anne, Guery, Clémence, Lasnon, Charline, Ciappuccini, Renaud, Legrand, Bérénice, Estienne, Adrien, and Christy, François

Published
2024
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12. Head and neck cancer patients under radiotherapy undergoing skin application of hydrogel dressing or hyaluronic acid: results from a prospective, randomized study

Author

Perréard, Marion, primary, Heutte, Natacha, additional, Clarisse, Bénédicte, additional, Humbert, Maxime, additional, Leconte, Alexandra, additional, Géry, Bernard, additional, Boisserie, Thomas, additional, Dadoun, Nathalie, additional, Martin, Laurent, additional, Blanchard, David, additional, Babin, Emmanuel, additional, and Bastit, Vianney, additional

Published
2023
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13. Management of 80 sinonasal undifferentiated carcinomas. Retrospective multicentre study of the French Network of Rare Head and Neck Cancers (REFCOR)

Author

Pouvreau, Pierre, primary, Coelho, Julien, additional, Rumeau, Cécile, additional, Malard, Olivier, additional, Garrel, Renaud, additional, Michel, Justin, additional, Righini, Christian, additional, Vergez, Sebastien, additional, Baudouin, Robin, additional, Bastit, Vianney, additional, Marie, Jean-Paul, additional, Villepelet, Aude, additional, Moya-Plana, Antoine, additional, Philouze, Pierre, additional, Saroul, Nicolas, additional, Digue, Laurence, additional, Daste, Amaury, additional, Renard, Sophie, additional, Moriniere, Sylvain, additional, Carsuzaa, Florent, additional, Verillaud, Benjamin, additional, Poissonnet, Gilles, additional, Schultz, Philippe, additional, Brenet, Esteban, additional, Mouawad, François, additional, Thariat, Juliette, additional, Vulquin, Noémie, additional, Castain, Claire, additional, de Gabory, Ludovic, additional, and Dupin, Charles, additional

Published
2023
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14. FRI689 First-line F18-choline PET/CT Versus Tc99m-sestaMIBI SPECT/CT In The Surgical Management Of Primary Hyperparathyroidism: The Multicentre APACH2 Phase III Trial

Author

Quak, Elske, primary, Lasne-Cardon, Audrey, additional, Cavarec, Marie-Béatrice, additional, Lireux, Barbara, additional, Bastit, Vianney, additional, Roudaut, Nathalie, additional, Salaun, Pierre-Yves, additional, Keromnes, Nathalie, additional, Potard, Gael, additional, Vaduva, Patricia, additional, Esvant, Annabelle, additional, Jegoux, Franck, additional, Crouy-Chanel, Olivier, additional, Devillers, Anne, additional, Guery, Clémence, additional, Lasnon, Charline, additional, Ciappuccini, Renaud, additional, Dauda, Mohammed Sali, additional, Legrand, Bérénice, additional, Estienne, Adrien, additional, Grellard, Jean-Michel, additional, Bardet, Stephane, additional, and Clarisse, Benedicte, additional

Published
2023
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16. Treatment strategy in laryngeal chondrosarcoma: a multicenter study of 43 cases

Author

Schleich, Marianne, primary, Laccourreye, Laurent, additional, Marianowski, Remi, additional, Dufour, Xavier, additional, Babin, Emmanuel, additional, Bastit, Vianney, additional, Marie, Jean Paul, additional, Badoual, Cécile, additional, Philouze, Pierre, additional, Espitalier, Florent, additional, Du Bouexic De Pinieux, Gonzague, additional, and Moriniere, Sylvain, additional

Published
2023
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17. From precise surgery to precision surgery: The multiple dimensions of therapeutic precision for head and neck cancer

Author

Galmiche, Antoine, primary, Saidak, Zuzana, additional, Babin, Emmanuel, additional, Brenet, Esteban, additional, Davrou, Julien, additional, Fournier, Isabelle, additional, Devauchelle, Bernard, additional, Testelin, Sylvie, additional, Dakpe, Stephanie, additional, Pellet, Adrien, additional, Thariat, Juliette, additional, Bastit, Vianney, additional, Clatot, Florian, additional, Saintigny, Pierre, additional, Bouaoud, Jebrane, additional, and Foy, Jean-Philippe, additional

Published
2023
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18. Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases

Author

Dahan, Laurie Saloner, primary, Giorgi, Roch, additional, Vergez, Sébastien, additional, Le Taillandier de Gabory, Ludovic, additional, Costes-Martineau, Valérie, additional, Herman, Philippe, additional, Poissonnet, Gilles, additional, Mauvais, Olivier, additional, Malard, Olivier, additional, Garrel, Renaud, additional, Uro-Coste, Emmanuelle, additional, Barry, Béatrix, additional, Bach, Christine, additional, Chevalier, Dominique, additional, Mouawad, Francois, additional, Merol, Jean-Claude, additional, Bastit, Vianney, additional, Thariat, Juliette, additional, Gilain, Laurent, additional, Dufour, Xavier, additional, Righini, Christian-Adrien, additional, Moya-Plana, Antoine, additional, Even, Caroline, additional, Radulesco, Thomas, additional, Michel, Justin, additional, Baujat, Bertrand, additional, Fakhry, Nicolas, additional, Albert, S., additional, Andry, G., additional, Babin, E., additional, Bach, C., additional, Badet, J.-M., additional, Badoual, C., additional, Baglin, A.C., additional, Banal, A., additional, Barry, B., additional, Baudin, E., additional, Baujat, B., additional, Bensadoun, R.J., additional, Bertolus, C., additional, Bessède, J.-P., additional, Blanchard, D., additional, Borel, C., additional, Bozorg-Grayeli, A., additional, Breheret, R., additional, Breton, P., additional, Brugel, L., additional, Calais, G., additional, Casiraghi, O., additional, Cassagnau, E., additional, Castillo, L., additional, Ceruse, P., additional, Chabolle, F., additional, Chevalier, D., additional, Chobaut, J.C., additional, Choussy, O., additional, Cosmidis, A., additional, Coste, A., additional, Costes, V., additional, Crampette, L., additional, Darrouzet, V., additional, Demez, P., additional, Dessi, P., additional, Devauchelle, B., additional, Dolivet, G., additional, Dubrulle, F., additional, Duflo, S., additional, Dufour, X., additional, Faivre, S., additional, Fakhry, N., additional, Ferron, C., additional, Floret, F., additional, de Gabory, L., additional, Garrel, R., additional, Geoffrois, L., additional, Gilain, L., additional, Giovanni, A., additional, Girod, A., additional, Guerrier, B., additional, Hans, S., additional, Herman, P., additional, Hofman, P., additional, Housset, M., additional, Jankowski, R., additional, Jegoux, F., additional, Juliéron, M., additional, Kaminsky, M.-C., additional, Kolb, F., additional, St Guily, J. Lacau, additional, Laccoureye, L., additional, Lallemant, B., additional, Lang, P., additional, Lartigau, E., additional, Lavieille, J.-P., additional, Lefevre, M., additional, Leroy, X., additional, Malard, O., additional, Massip, F., additional, Mauvais, O., additional, Merol, J.-C., additional, Michel, J., additional, Mom, T., additional, Morinière, S., additional, de Monès, E., additional, Moulin, G., additional, Noel, G., additional, Poissonnet, G., additional, Prades, J.-M., additional, Radulesco, T., additional, de Raucourt, D., additional, Reyt, E., additional, Righini, C., additional, Robin, Y. Marie, additional, Rolland, F., additional, Ruhin, B., additional, Sarroul, N., additional, Schultz, P., additional, Serrano, E., additional, Sterkers, O., additional, Strunski, V., additional, Sudaka, A., additional, Tassart, M., additional, Testelin, S., additional, Thariat, J., additional, Timochenko, A., additional, Toussaint, B., additional, Coste, E. Uro, additional, Valette, G., additional, Van den Abbeele, T., additional, Varoquaux, A., additional, Veillon, F., additional, Vergez, S., additional, and Wassef, M., additional

Published
2021
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19. 18F-Fluorocholine Positron Emission Tomography/Computed Tomography is a Highly Sensitive but Poorly Specific Tool for Identifying Malignancy in Thyroid Nodules with Indeterminate Cytology: The Chocolate Study

Author

Ciappuccini, Renaud, primary, Licaj, Idlir, additional, Lasne-Cardon, Audrey, additional, Babin, Emmanuel, additional, de Raucourt, Dominique, additional, Blanchard, David, additional, Bastit, Vianney, additional, Saguet-Rysanek, Virginie, additional, Lequesne, Justine, additional, Peyronnet, Damien, additional, Grellard, Jean-Michel, additional, Clarisse, Bénédicte, additional, and Bardet, Stéphane, additional

Published
2021
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20. Equivalence Randomized Trial to Compare Treatment on the Basis of Sentinel Node Biopsy Versus Neck Node Dissection in Operable T1-T2N0 Oral and Oropharyngeal Cancer

Author

Garrel, Renaud, primary, Poissonnet, Gilles, additional, Moyà Plana, Antoine, additional, Fakhry, Nicolas, additional, Dolivet, Gilles, additional, Lallemant, Benjamin, additional, Sarini, Jérôme, additional, Vergez, Sebastien, additional, Guelfucci, Bruno, additional, Choussy, Olivier, additional, Bastit, Vianney, additional, Richard, Fanny, additional, Costes, Valérie, additional, Landais, Paul, additional, Perriard, Françoise, additional, Daures, Jean Pierre, additional, de Verbizier, Delphine, additional, Favier, Valentin, additional, and de Boutray, Marie, additional

Published
2020
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21. Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19)

Author

Lièvre, Astrid, primary, Turpin, Anthony, additional, Ray-Coquard, Isabelle, additional, Le Malicot, Karine, additional, Thariat, Juliette, additional, Ahle, Guido, additional, Neuzillet, Cindy, additional, Paoletti, Xavier, additional, Bouché, Olivier, additional, Aldabbagh, Kais, additional, Michel, Pierre, additional, Debieuvre, Didier, additional, Canellas, Anthony, additional, Wislez, Marie, additional, Laurent, Lucie, additional, Mabro, May, additional, Colle, Raphael, additional, Hardy-Bessard, Anne-Claire, additional, Mansi, Laura, additional, Colomba, Emeline, additional, Bourhis, Jean, additional, Gorphe, Philippe, additional, Pointreau, Yoann, additional, Idbaih, Ahmed, additional, Ursu, Renata, additional, Di Stefano, Anna Luisa, additional, Zalcman, Gérard, additional, Aparicio, Thomas, additional, Moulin, Solenne, additional, Leleu, Olivier, additional, Leparree, Sylvie, additional, Goasdoue, Henri, additional, Piprot, Christine, additional, Tourneur, Gerald, additional, Bayart, Vincent, additional, Lignier, Delphine, additional, Lachaier, Emma, additional, Khamari, Marwa, additional, Coutte, Alexandre, additional, Siembida, Nicolas, additional, Houessinon, Aline, additional, Regimbeau, Jean Marc, additional, Chauffert, Bruno, additional, Moreira, Aurélie, additional, Hautefeuille, Vincent, additional, Hee, Christine, additional, Boone, Mathieu, additional, Bihan, Céline, additional, Chive, Emilie, additional, Poulet-Potriquier, Stéphane, additional, Fahem, Rachida, additional, Luet, Dominique, additional, Roquin, Guillaume, additional, Vitellius, Carole, additional, Cornet-Trichereau, Nathanaëlle, additional, Caroli-Bosc, François-Xavier, additional, Thirot-Bidault, Anne, additional, Ropert, Stanislas, additional, Gachet - Masson, Julie, additional, Dehais, Mélanie, additional, L'helgoualc'h, Gwen-Ael, additional, Ali-Mahamadou, Ibrahim, additional, Talfi, Safia, additional, Belmont, Laure, additional, Kilendo, Dieudonné, additional, Benrezzak, Nasro, additional, Dubief, Emeline, additional, Conroy, Guillaume, additional, Delique, Laurence, additional, Basso, Maud, additional, Pons, Isabelle, additional, Salignon, Karine, additional, Villing, Anne-Laure, additional, Mougenot, Emmanuelle, additional, Porebski, Cassandra, additional, Guiatni, Asma, additional, Cloarec, Nicolas, additional, Mineur, Laurent, additional, Bouchaud, Marie, additional, David, Céleste, additional, Peytier, Annie, additional, Greletty, Thomas, additional, Audemar, Franck, additional, Vignes, Emanuelle, additional, Minne, Floriane, additional, Goldzak, Guillaume, additional, Huysman, Fabienne, additional, Hocine, Fayçal, additional, Lakkis, Zaher, additional, Meynard, Guillaume, additional, Almotlak, Hamadi, additional, Klajer, Elodie, additional, Sun, Xu-Shan, additional, Wasselin, Julie, additional, Catala, Pascale, additional, Mazuy, Claire, additional, Vandamme, Hélène, additional, Prevost, Jean-Briac, additional, Fadin, Aurélie, additional, Basson, Laurent, additional, Huguet, Jean-Baptiste, additional, Dos Santos, Emmanuelle, additional, Jany, Bérangère, additional, Saad, Alain, additional, Goutorbe, Frédéric, additional, Oziol, Eric, additional, Ramdani, Mohamed, additional, Kadiri, Ouafae, additional, Garbay, Delphine, additional, Huet, Clotilde, additional, Giroux Leprieur, Etienne, additional, Teng, Wen, additional, Monvoisin, Justine, additional, Arnaud Coffin, Patrick, additional, Roux, Sylvie, additional, Orfeuvre, Hubert, additional, Chagros, Mélanie, additional, Pillon, Didier, additional, Rassoul, Agathe, additional, Poureau, Pierre Guillaume, additional, Novello, Cécile, additional, Ducray, François, additional, Trouba, Cécile, additional, Bastit, Vianney, additional, Babin, Emmanuel, additional, Leon, Vincent, additional, Courtecuisse, Anne-Catherine, additional, Vambre, Julie, additional, Tack, Vincent, additional, Desauw, Christophe, additional, Meniai, Fatima, additional, Peres, Christina, additional, Esparcieux, Aurélie, additional, Perrier, Hervé, additional, Doux, Nathalie, additional, Kaphan, Régis, additional, Roques, Bertrand, additional, Rebischung, Christine, additional, Mille, Dominique, additional, Fernandes, Gaëlle, additional, Abdelli, Naceur, additional, Jousset, Natacha, additional, Combe, Pierre, additional, Jonveaux, Eric, additional, Dumont, Patrick, additional, Kanaan, Marc, additional, Berthelot Gras, Corinne, additional, Panis, Valérie, additional, Kaluzinski, Laure, additional, Venant-Valery, Marjolène, additional, Lam, You-Heng, additional, Vallee, Laura, additional, Riviere, Frédéric, additional, Durand, Muriel, additional, Benghadid, Dihya, additional, Villeneuve, Emilie, additional, Hentic Dhome, Olivia, additional, Bounouar, Zedjiga, additional, De Mestier, Louis, additional, Dubois, Jacqueline, additional, Eyriey, Magali, additional, Moreau, Lionel, additional, Baihas, Dib, additional, Aldabbagh, Kaïs, additional, Degriffolet, Dominique, additional, Sebbagh, Virginie, additional, Seghezzi, Jean-Christophe, additional, Lozach-Brugirard, Marion, additional, Mandrou, Julie, additional, Mavier, Loubna, additional, Hennetier, Florence, additional, Wagner, Jean-Philippe, additional, Carola, Elisabeth, additional, Chandirakumaran, Karthiga, additional, Loutski, Sandrine, additional, Cojean-Zelek, Isabelle, additional, Bouras, Amina, additional, Lacour, Sandrine, additional, Froura, Fahem, additional, Ben Nadji, Hadjer, additional, Cattelain, Sophie, additional, Darloy, Franck, additional, Jolimoy Boilleau, Geneviève, additional, Maissiat, Cyrielle, additional, Darut-Jouve, Ariane, additional, Lorgis, Véronique, additional, Charifi-Alaoui, Ikram, additional, Ghiringhelli, François, additional, Drouillard, Antoine, additional, Chaix, Marie, additional, Manfredi, Sylvain, additional, Lepage, Côme, additional, Gagnaire, Alice, additional, Latournerie, Marianne, additional, jourdan, Sofia, additional, Perrot, Nora, additional, folia, Mireille, additional, Minello, Anne, additional, Jouve, Jean-Louis, additional, Fery, Marielle, additional, Landau, Alain, additional, Evrard, Diane, additional, Valenza, Bruno, additional, Paitel, Jean-François, additional, Chablais, Laetitia, additional, Kreitmann, Thomas, additional, Lancry-Lecomte, Laurence, additional, Monard, Adrien, additional, Faugeras, Eve, additional, Boucheret, Paul, additional, Glommeau, Cécile, additional, Tchikladze, Christine, additional, Garnier Tixidre, Claire, additional, Long, Jérôme, additional, Zaidi, Manel, additional, Delabarre, Véronique, additional, Meyzenc, Juliette, additional, Ferrand, Loïc, additional, Moro-Sibilot, Denis, additional, Bouheret, Paul, additional, Leyronnas, Cécile, additional, Herve, Camille, additional, Thoor, Audrey, additional, Jacquet, Emanuelle, additional, Roth, Gaël, additional, Madapathage-Senanyake, Videsheka, additional, Chupeau, Peggy, additional, Bieber, Elsa, additional, Rosso, Maud, additional, Lepage, Isabelle, additional, Priou, Frank, additional, Laly, Margot, additional, Aprelon, Sylvie, additional, Sobolak, Natacha, additional, Homokos, Helen, additional, Watelle, Fabienne, additional, Pham-Becker, Alice, additional, Lauridant, Géraldine, additional, Dujardin, Charlotte, additional, Lenglin, Etienne, additional, Nienguet Tsota, Aimée, additional, Dominguez, Sophie, additional, Forestier, Alexandra, additional, Nouvel, Franck, additional, Lerooy, Justine, additional, Ratajczak, Céline, additional, Romano, Olivier, additional, Brzyski, Dorothéee, additional, Barriere, Aurélien, additional, Genet, Dominique, additional, Tisse, Julien, additional, Zasadny, Xavier, additional, Grelet, Adeline, additional, Hennion-Imbault, Amélie, additional, Haustraete, Eglantine, additional, Louafi, Samy, additional, Awad, Manal, additional, Zekri, Younes, additional, Cheneau, Caroline, additional, Leissen, Nolwen, additional, Egreteau, Joëlle, additional, Breant, Alexandra, additional, Sarabi, Matthieu, additional, Labonne, Stéphanie, additional, Forestier, Julien, additional, Leclercq, Céline, additional, Prunier-Bossion, Florence, additional, Ray Coquard, Isabelle, additional, Guillet, Marielle, additional, Theillaumas, Aurélie, additional, Prome, Emilie, additional, Walter, Thomas, additional, Philouze, Pierre, additional, Lawo, Melody, additional, De Talhouet, Solène, additional, Beuvelot, Johanne, additional, Molin, Yann, additional, Bellecoste Martin, Marie, additional, Saussereau, Maud, additional, Agnelli, Lauren, additional, Fakhry, Nicolas, additional, Laplace, Christophe, additional, Norguet Monnereau, Emmanuelle, additional, Boucard, Céline, additional, Djenad, Kahina, additional, Fontaine, Catherine, additional, Seitz, Jean-François, additional, Dahan, Laétitia, additional, Sigrand, Julie, additional, Duluc, Muriel, additional, Locher, Christophe, additional, Fleury, Marjory, additional, Brou Marie, Ange, additional, Berkane, Ramdane, additional, Poupblanc, Séverine, additional, Auby, Dominique, additional, Petran, Daniela, additional, Texereau, Patrick, additional, Guerineau, Elodie, additional, Andre, Morgan, additional, Mahjoubi, Linda, additional, Sarrazin, Fanny, additional, Jeanson, Sonia, additional, Gschwend, Anthony, additional, Birr, Virginie, additional, Fore, Mathieu, additional, Noirclerc, Monique, additional, Dahou, Sihem, additional, Spaeth, Dominique, additional, Lambotin, Mélanie, additional, Lelu, Thomas, additional, Linot, Benjamin, additional, Hugon, Nathalie, additional, Rousseau, Dominique, additional, Castanie, Hélène, additional, Lenne, Carole, additional, Lortholary, Alain, additional, Cessot, Anatole, additional, Merzoug, Messaouda, additional, Naudin, Cécile, additional, Vannetzel, Jean-Michel, additional, Aziz, Ghina, additional, Hadj Arab, Yacine, additional, Pernes, Stéphanie, additional, Roche-Lachaise, Isabelle, additional, Fiteni, Frédéric, additional, Yahiaoui, Hadjer, additional, Marel Lopez, Gwendoline, additional, Oddoz, Jeanne, additional, Peira, Fabienne, additional, Michel, Olivier, additional, Meunier, Jérôme, additional, Ouahrani, Brahim, additional, Roger, Antoine, additional, Branco, Sonia, additional, Nguyen, Van, additional, Gisselbrecht, Mathilde, additional, Hammad, Ghania, additional, Mordant, Pierre, additional, Stroksztejn, Magda, additional, Pocard, Marc, additional, Nlo Meyengue, Luc, additional, Sacco, Emmanuelle, additional, Simon Anne, Sophie, additional, Fabre-Guillevin, Elizabeth, additional, Slim, Marine, additional, Zaanan, Aziz, additional, Cadranel, Jacques, additional, Pluvy, Johan, additional, Ursu, Rénata, additional, Geraldo, Amyrath, additional, Lihi, Rime, additional, Vo, Maryline, additional, Brouk, Zohra, additional, Colle, Raphaël, additional, Bennamoun, Mostefa, additional, Lacan, Fabrice, additional, Louvet, Christophe, additional, Mebarki, Soraya, additional, Veyri, Marianne, additional, Paillaud, Elena, additional, Lucas, Christelle, additional, Dubreuil, Olivier, additional, Lyamani, Jamila, additional, Agguini, Hanane, additional, Soularue, Emilie, additional, Jourdaine, Clément, additional, Verillaud, Benjamin, additional, Herzine, Hakima, additional, Raymond, Eric, additional, Mathiot, Nathalie, additional, Palmieri, Lola Jade, additional, Epanya, Christian, additional, Taieb, Julien, additional, Bertrand, Eliane, additional, Goujon, Gaël, additional, Namour, Céline, additional, Gazeau, Benoit, additional, Zafirova, Biljana, additional, Mirghani, Haitham, additional, Belin, Catherine, additional, Belkhir, Kahina, additional, Gharib, Myriam, additional, Vozy, Aurore, additional, Amrane, Karim, additional, Spano, Jean-Philippe, additional, Wassermann, Johanna, additional, Feuvret, Loic, additional, Bachet, Jean-Baptiste, additional, Philonenko, Sara, additional, Guillot, Laetitia, additional, Zabbe, Marion, additional, Gibiat, Stéphanie, additional, Baylot, Camille, additional, Jouinot, Aude, additional, Leduc, Nicolas, additional, Vieillot, Sabine, additional, James, Laurie, additional, Ducerf, Camille, additional, Blanc, Jean-Frédéric, additional, Falandry Leger, Claire, additional, Wautot, Virginie, additional, Chauvenet, Marion, additional, Vincent, Aude, additional, Tougeron, David, additional, Goulvent, Sandrine, additional, Suc, Etienne, additional, Laurenty, Anne-Pascale, additional, Marquis, Eric, additional, Bonnaire, Margaux, additional, Dewolf, Maxime, additional, Brenet, Esteban, additional, Billard, Delphine, additional, Litre, Claude-Fabien, additional, Dumazet, Antoine, additional, Botsen, Damien, additional, Vazel, Marion, additional, Carlier, Claire, additional, Bonnerave, David, additional, Marchand-Crety, Charles, additional, Bouche, Olivier, additional, Fosse, Patricia, additional, Sefrioui, David, additional, Watson, Sarah, additional, Torche, Fatah, additional, Muron, Thierry, additional, Natur, Stéphane, additional, Desgrippes, Romain, additional, Bihel, Véronique, additional, Ferrand, François-Régis, additional, Leiterer, Caroline, additional, Lavole, Julie, additional, Moquet, Claire, additional, Pressoir, Nathalie, additional, Dziukala, Catherine, additional, Ligeza Poisson, Catherine, additional, Naji, Abdelhalim, additional, Williet, Nicolas, additional, Phelip, Jean-Marc, additional, Di Palma, Fabrice, additional, Kherrour Mehdi, Amina, additional, Langrand-Escure, Julien, additional, Fournel, Pierre, additional, Pigne, Grégoire, additional, Saban-Roche, Léa, additional, Magne, Nicolas, additional, Vassal, Cécile, additional, Jacquin, Jean-Philippe, additional, Ramirez, Carole, additional, Vallard, Alexis, additional, Collard, Olivier, additional, Rivoirard, Romain, additional, Graber, Ivan, additional, Trager Maury, Stéphanie, additional, Duboisset, Elodie, additional, Ayllon Ugarte, Jorge, additional, Rami, Dalilia, additional, Saler, Christine, additional, Reinbolt, Manon, additional, Le Fevre, Clara, additional, Ben Abdelghani, Meher, additional, Dourthe, Louis-Marie, additional, Perruisseau-Carrier, Joffrey, additional, Nguimpi-Tambou, Marlène, additional, Barret, Flavie, additional, Di Stefano Anna, Luisa, additional, Balthazard, Annie, additional, Vassord-Dang, Camille, additional, Le Marchand, Mathilde, additional, Vergniol, Julien, additional, Pripon, Iulia, additional, Daemaegdt, Axelle, additional, Latry, Vanessa, additional, Larrieu, Muna, additional, Landry, Gaëlle, additional, Touihri Maximin, Laetitia, additional, Del Piano, Francesco, additional, Barlet, Agnès, additional, Vernisse, Mylène, additional, Lafond, Sophie, additional, Genin, Charline, additional, Sibertin-Blanc, Camille, additional, Chabrillac, Emilien, additional, Gregoire, Caroline, additional, Vergez, Sébastien, additional, Panouille, Quentin, additional, Guimbaud, Rosine, additional, Richa, Floriane, additional, Lebellec, Loïc, additional, Gounin, Sophie, additional, Buiret, Guillaume, additional, Baudin, Marine, additional, Hamon, Hervé, additional, Deshorgue, Anne-Claire, additional, Barrascout, Eduardo, additional, Legrand, Stéphanie, additional, Houlze, Morgane, additional, Cambula, Linda, additional, Lopez, Anthony, additional, Fouquet, Guillaume, additional, Touabi, Kahina, additional, GermaIn, Adeline, additional, Godbert, Benoit, additional, Voivret, Florence, additional, Perrin, Julie, additional, Da Silva, Rosa, additional, and Bernichon, Emilie, additional

Published
2020
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22. Management of cN0 low‐grade mucoepidermoid carcinomas of salivary glands: Prospective multicentre study of 152 cases of the French Network of Rare Head and Neck Tumors (REFCOR)

Author

Saloner Dahan, Laurie, primary, Giorgi, Roch, additional, Garrel, Renaud, additional, Le Taillandier de Gabory, Ludovic, additional, Costes‐Martineau, Valérie, additional, Herman, Philippe, additional, Poissonnet, Gilles, additional, Mauvais, Olivier, additional, Malard, Olivier, additional, Vergez, Sébastien, additional, Uro‐Coste, Emmanuelle, additional, Barry, Béatrix, additional, Bach, Christine, additional, Chevalier, Dominique, additional, Mouawad, Francois, additional, Merol, Jean‐Claude, additional, Bastit, Vianney, additional, Thariat, Juliette, additional, Gilain, Laurent, additional, Dufour, Xavier, additional, Righini, Christian‐Adrien, additional, Dessi, Patrick, additional, Michel, Justin, additional, Radulesco, Thomas, additional, Even, Caroline, additional, Baujat, Bertrand, additional, and Fakhry, Nicolas, additional

Published
2020
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23. International assessment of interobserver reproducibility of flap delineation in head and neck carcinoma.

Author

Beddok, Arnaud, Guzene, Leslie, Coutte, Alexandre, Thomson, David, Yom, Sue S., Calugaru, Valentin, Blais, Eivind, Gilliot, Olivier, Racadot, Séverine, Pointreau, Yoann, Corry, June, Jensen, Kenneth, Porceddu, Sandro, Khalladi, Nazim, Bastit, Vianney, Lasne-Cardon, Audrey, Marcy, Pierre-Yves, Carsuzaa, Florent, Nioche, Christophe, and Bourhis, Jean

Subjects
CANCER radiotherapy, SURGICAL flaps, HEAD & neck cancer, HEALTH outcome assessment, INTER-observer reliability, PECTORALIS muscle, COMPARATIVE studies, DESCRIPTIVE statistics, STATISTICAL correlation, RADIOTHERAPY
Abstract

Background: Several reports have suggested that radiotherapy after reconstructive surgery for head and neck cancer (HNC), could have deleterious effects on the flaps with respect to functional outcomes. To predict and prevent toxicities, flap delineation should be accurate and reproducible. The objective of the present study was to evaluate the interobserver variability of frequent types of flaps used in HNC, based on the recent GORTEC atlas. Materials and methods: Each member of an international working group (WG) consisting of 14 experts delineated the flaps on a CT set from six patients. Each patient had one of the five most commonly used flaps in HNC: a regional pedicled pectoralis major myocutaneous flap, a local pedicled rotational soft tissue facial artery musculo-mucosal (FAMM) (2 patients), a fasciocutaneous radial forearm free flap, a soft tissue anterolateral thigh (ALT) free flap, or a fibular free flap. The WG's contours were compared to a reference contour, validated by a surgeon and a radiologist specializing in HNC. Contours were considered as reproducible if the median Dice Similarity Coefficient (DSC) was > 0.7. Results: The median volumes of the six flaps delineated by the WG were close to the reference contour value, with approximately 50 cc for the pectoral, fibula, and ALT flaps, 20 cc for the radial forearm, and up to 10 cc for the FAMM. The volumetric ratio was thus close to the optimal value of 100% for all flaps. The median DSC obtained by the WG compared to the reference for the pectoralis flap, the FAMM, the radial forearm flap, ALT flap, and the fibular flap were 0.82, 0.40, 0.76, 0.81, and 0.76, respectively. Conclusions: This study showed that the delineation of four main flaps used for HNC was reproducible. The delineation of the FAMM, however, requires close cooperation between radiologist, surgeon and radiation oncologist because of the poor visibility of this flap on CT and its small size. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Factors associated with non-completion of radiation therapy (RT) or radiochemotherapy (RTCT) in head and neck squamous cell carcinoma (HNSCC): A prospective study.

Author

Clatot, Florian, primary, Lebret, Lucie, additional, Rigal, Olivier, additional, Lefebvre, Laureline, additional, Dandoy, Simon, additional, Cabourg, Marine, additional, Moldovan, Cristian, additional, Veresezan, Ovidiu, additional, Thery, Jean Christophe, additional, Petrau, Camille, additional, Lebreton, Mathilde, additional, Guérault, Fanny, additional, Ebran, Mélanie, additional, Gouley-Toutain, Céline, additional, Bon-Mardion, Nicolas, additional, Bastit, Vianney, additional, Di Fiore, Frédéric, additional, Dubray, Bernard M., additional, Lequesne, Justine, additional, and Thureau, Sébastien, additional

Published
2019
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25. 18F-Fluorocholine Positron Emission Tomography/Computed Tomography is a Highly Sensitive but Poorly Specific Tool for Identifying Malignancy in Thyroid Nodules with Indeterminate Cytology: The Chocolate Study.

Author

Ciappuccini, Renaud, Licaj, Idlir, Lasne-Cardon, Audrey, Babin, Emmanuel, de Raucourt, Dominique, Blanchard, David, Bastit, Vianney, Saguet-Rysanek, Virginie, Lequesne, Justine, Peyronnet, Damien, Grellard, Jean-Michel, Clarisse, Bénédicte, and Bardet, Stéphane

Subjects
POSITRON emission tomography computed tomography, COMPUTED tomography, THYROID nodules, CYTOLOGY, ACOUSTIC radiation force impulse imaging
Abstract

Background: Refining the risk of malignancy in patients presenting with thyroid nodules with indeterminate cytology (IC) is a critical challenge. We investigated the performances of 18F-fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) to predict malignancy. Methods: Between May 2016 and March 2019, 107 patients presenting with a thyroid nodule ≥15 mm with IC and eligible for surgery were included in this prospective study. Head-and-neck PET/CT acquisitions were performed 20 and 60 minutes after injection of 1.5 MBq/kg of FCH. PET/CT acquisition was scored positive when maximal standardized uptake value in the IC nodule was higher than in the thyroid background. Pathology was the gold standard for diagnosis. Results: At pathology, 19 (18%) nodules were malignant, 87 were benign, and one was a noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Sensitivity, specificity, accuracy, positive-predictive value (PPV), and negative-predictive value (NPV) of FCH PET/CT in detecting cancer or NIFTP were 90%, 50%, 55%, 29%, and 96% at 20 minutes and 85%, 49%, 67%, 28%, and 94% at 60 minutes, respectively. Higher specificity (58% vs. 33%, p = 0.01) was observed in nononcocytic (n = 72) than in oncocytic IC nodules (n = 35). The pre-PET/CT probability of cancer or NIFTP in Bethesda III–IV nodules was 11% and the post-PET/CT probability was 19% in PET-positives and 0% in PET-negatives. In retrospective analysis, 42% of surgeries would have been unnecessary after PET/CT and 81% before (p < 0.001), resulting in a hypothetical 48% reduction (95% confidence interval [32–64]). Conclusions: FCH PET/CT offers high NPV to reliably exclude cancer in PET-negative IC nodules, but suffers from low PPV, particularly in those with oncocytic cytology. ClinicalTrials.gov identifier: NCT02784223. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Benefit of cetuximab addition to a platinum–fluorouracil-based chemotherapy according to KRAS-LCS6 variant in an unselected population of recurrent and/or metastatic head and neck cancers

Author

Bastit, Vianney, primary, Bon-Mardion, Nicolas, additional, Picquenot, Jean-Michel, additional, Rainville, Vinciane, additional, Moldovan, Cristian, additional, François, Arnaud, additional, Loeb, Agnès, additional, Thureau, Sébastien, additional, Manu, Dorel, additional, Jardin, Fabrice, additional, Marie, Jean-Paul, additional, Di Fiore, Fréderic, additional, and Clatot, Florian, additional

Published
2018
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27. Effet de la mutation KRAS LCS6 variant sur la Sensibilité au Cetuximab en première ligne de chimiothérapie palliative dans les carcinomes épidermoïdes des VADS

Author

Bastit, Vianney, UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), and Florian Clatot

Subjects
KRAS 3'UTR polymorphism, Polymorphisme KRAS 3’UTR, EGFR, Carcinomes épidermoïdes des VADS, KRAS LCS6, rs61764370, Metastatic Head and Neck Carcinoma, Cetuximab, HNSCC, Chimiothérapie, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Métastatique
Abstract

KRAS LCS6 variant is a single nucleotid polymorphism in the 3’UTR of KRAS, (a Let7 microRNA binding site) and could induced an EGFR oncogenic dependance by loss of KRAS downregulation. It could thus involve a greater sensibily to EGFR-targeted therapy. The main objective is to evaluate the association between KRAS LCS6 variant and response to Cetuximab (Cx) in metastatic Head and Neck carcinoma. Methods : Patients treated by Platinum – 5FU +/- Cx in first line of palliative chemotherapy were included. KRAS LCS6 variant (rs61764370) was determined by pyrosequencing after DNA extraction on formalin-fixed paraffinembedded tissues. The overall (OS) and progression-free survival (PFS) was calculated by Kaplan-Meier method and compared by log-rank test. Results: 134 patients were included. 56% were treated with Cx. KRAS genotype could be determined in 110 patients. The prevalence of KRAS LCS6 was 25%. There was no survival difference between KRAS-variant and KRAS-wildtype in OS (HR IC95 0.9 [0.6 to 1.4]; p = 0.6) and PFS (HR 0.9 IC95 [0.6 to 1.4], p = 0.7). In the Cx+ group, presence of variation was not associated with response to treatment (HR = 0.9 [0.5 to 1.5]; p = 0.5). Over the whole population (n = 134), median PFS was 6.1 months [1.5 to 32.2] in Cx+ group and 4.4 months [1.6 to 26.5] in Cx- group (HR 0.68 CI95 [0.5 to 0.97], p = 0.02). Median OS was 11.1 months [1.6 to 38.6] in Cx+ group and 9.07 months [2.3 to 44.1] in Cx- group (HR 0.79 IC95 [ 0.6 to 1.1], p = 0.2). Conclusion: KRAS LCS6 variant does not seem to be predictive of response to Cetuximab in metastatic Head and Neck carcinoma. This polymorphism does not appear as a prognostic factor in this population. Furthermore, we confirmed the effectiveness of EXTREME protocol in an unselected population.; Une variation du gène KRAS (3’UTR KRAS Variant, LCS6) au niveau d’un site de fixation de micro-ARN Let-7 induirait une dépendance oncogénique vis-à-vis de l’EGFR par perte de la régulation négative de KRAS, impliquant une plus grande sensibilité aux anti-EGFR comme le Cetuximab (Cx). L’objectif principal est d’évaluer l’association entre la variation KRAS LCS6 et la réponse au Cetuximab dans les carcinomes épidermoïdes des VADS métastatiques. Méthodes : Les patients traités par au moins deux cures chimiothérapie en 1ère ligne palliative par Platine – 5FU +/- Cx de 2005 à 2014 étaient inclus. Le génotype KRAS LCS6 variant (rs61764370) était déterminé par pyroséquençage après extraction des ADN sur prélèvements paraffinés. Les survies globales (SG) et sans progression (SSP) était calculées par méthode de Kaplan Meier et comparés par test du log-rank. Résultats : 134 patients ont été inclus dont 56% traité par Cx. Le génotype KRAS a pu être déterminé chez 110 patients. La prévalence de KRAS LCS6 était de 25%. Il n’existait pas de différence de survie entre les groupes KRAS variant et KRAS Sauvage en SG (HR 0,9 IC95 [0,6 – 1,4] ; p=0,6) et en SSP (HR 0,9 IC95 [0,6 – 1,4] ; p=0,7). Chez les patients traités par Cx la présence de la variation n’était pas associée à la réponse au traitement (HR = 0.9 [0,5 – 1,5] ; p=0,5). Sur l’ensemble de population (n=134) la médiane de SSP était de 6,1 mois [1,5 – 32,2] dans le groupe Cx + et de 4,4 mois [1,6 – 26,5] dans le groupe Cx - (HR 0.68 IC95 [0,5 - 0,97], p=0,02). La médiane de SG était de 11,1 mois [1,6 – 38,6] dans le groupe Cx+ et de 9,07 mois [2,3 – 44,1] dans le groupe Cx- (HR 0,79 IC95 [0,6 – 1,1] ; p=0,2). Conclusion : La présence de la variation KRAS LCS6 ne semble pas prédictive de réponse au Cetuximab dans les carcinomes épidermoïdes de VADS métastatique. Ce polymorphisme n’apparaît pas comme facteur pronostic dans cette population. Par ailleurs, nous avons pu confirmer l’efficacité du protocole EXTREME dans une population non sélectionnée.

Published
2016

28. Malignant salivary gland tumors of the tongue: A multicenter REFCOR study.

Author

Poissonnet V, Uro-Coste E, Chabrillac E, Modesto A, Even C, Fakhry N, Garrel R, Malard O, Chatelet F, Dupin C, Jegoux F, Schultz P, Culié D, Baudouin R, Evrard D, Ransy P, Morinière S, Mirghani H, Mouawad F, Righini C, Duflo S, Marie JP, Jourdan-Soulier F, Atallah S, Brenet E, Bertolus C, Ceruse P, Ramin L, Dufour X, Nguyen DT, Bastit V, Segier B, and Vergez S

Subjects
Humans, Female, Male, Middle Aged, Retrospective Studies, Aged, Adult, Prognosis, Aged, 80 and over, Carcinoma, Mucoepidermoid pathology, Carcinoma, Mucoepidermoid therapy, Carcinoma, Adenoid Cystic therapy, Carcinoma, Adenoid Cystic pathology, Carcinoma, Adenoid Cystic mortality, Carcinoma, Adenoid Cystic diagnosis, Survival Rate, Adenocarcinoma pathology, Adenocarcinoma therapy, Adenocarcinoma diagnosis, Salivary Gland Neoplasms pathology, Salivary Gland Neoplasms therapy, Salivary Gland Neoplasms mortality, Salivary Gland Neoplasms diagnosis, Tongue Neoplasms pathology, Tongue Neoplasms therapy, Tongue Neoplasms mortality
Abstract

Salivary carcinomas of minor salivary glands are very infrequent tumors. When located in the tongue, the therapeutic strategy may comprise upfront surgery, which may be debilitating, and/or (chemo-)radiotherapy. The aim of this study was to identify the prognostic factors of salivary carcinomas of the tongue in a population-based cohort. This retrospective multicentric study, based on the "Réseau d'Expertise Français sur les Cancers ORL Rares" (REFCOR), included all the patients with a salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018. Dubious slides were reviewed by REFCOR expert pathologists to ensure diagnostic accuracy. Treatment was performed in accordance with national REFCOR recommendations. From 28 centers, 103 patients were included in this study. Median age at diagnosis was 63 years, and 60.2% were female. Tumors were adenoid cystic carcinomas (41.7%), mucoepidermoid carcinomas (30.1%), and other adenocarcinomas (28.2%). Primary treatment was surgical for 61.2% of them. Five-year overall survival (OS) and event-free survival (EFS) rates were 84.7% and 38.6%, respectively. In multivariable analysis, EFS was significantly worse in case of nonsurgical treatment, alcohol consumption, and glossotonsillar sulcus involvement. N-positive status was the only significant prognostic factor for OS in multivariable analysis. Salivary carcinomas of the tongue represent a heterogeneous group of rare tumors, with a high risk of recurrence. In this national cohort, surgery was associated with better EFS and N-status was the main independent prognostic factor for OS., (© 2024 UICC.)

Published
2025
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29. F18-Choline PET/CT or MIBI SPECT/CT in the Surgical Management of Primary Hyperparathyroidism: A Diagnostic Randomized Clinical Trial.

Author

Quak E, Lasne-Cardon A, Cavarec M, Lireux B, Bastit V, Roudaut N, Salaun PY, Keromnes N, Potard G, Vaduva P, Esvant A, Jegoux F, de Crouy-Chanel O, Devillers A, Guery C, Lasnon C, Ciappuccini R, Legrand B, Estienne A, Christy F, Grellard JM, Bardet S, and Clarisse B

Subjects
Humans, Female, Male, Middle Aged, Aged, Fluorine Radioisotopes, Parathyroid Neoplasms surgery, Parathyroid Neoplasms diagnostic imaging, Parathyroid Neoplasms complications, Adenoma surgery, Adenoma diagnostic imaging, Hyperparathyroidism, Primary surgery, Hyperparathyroidism, Primary diagnostic imaging, Hyperparathyroidism, Primary blood, Technetium Tc 99m Sestamibi, Positron Emission Tomography Computed Tomography methods, Parathyroidectomy methods, Choline, Radiopharmaceuticals
Abstract

Importance: Whether F18-choline (FCH) positron emission tomographic (PET)/computed tomographic (CT) scan can replace Tc99m-sestaMIBI (MIBI) single-photon emission (SPE)CT/CT as a first-line imaging technique for preoperative localization of parathyroid adenomas (PTA) in patients with primary hyperparathyroidism (PHPT) is unclear., Objective: To compare first-line FCH PET/CT vs MIBI SPECT/CT for optimal care in patients with PHPT needing parathyroidectomy and to compare the proportions of patients in whom the first-line imaging method resulted in successful minimally invasive parathyroidectomy (MIP) and normalization of calcemia 1 month after surgery., Design, Setting, and Participants: A French multicenter randomized open diagnostic intervention phase 3 trial was conducted. Patients were enrolled from November 2019 to May 2022 and participated up to 6 months after surgery. The study included adults with PHPT and an indication for surgical treatment. Patients with previous parathyroid surgery or multiple endocrine neoplasia type 1 (MEN1) were ineligible., Interventions: Patients were assigned in a 1:1 ratio to receive first-line FCH PET/CT (FCH1) or MIBI SPECT/CT (MIBI1). In the event of negative or inconclusive first-line imaging, they received second-line FCH PET/CT (FCH2) after MIBI1 or MIBI SPECT/CT (MIBI2) after FCH1. All patients underwent surgery under general anesthesia within 12 weeks following the last imaging. Clinical and biologic (serum calcemia and parathyroid hormone levels) assessments were performed 1 and 6 months after surgery., Main Outcomes and Measures: The primary outcome was a true-positive first-line imaging-guided MIP combined with uncorrected serum calcium levels of 2.55 mmol/l or less 1 month after surgery, corresponding to the local upper limit of normality., Results: Overall, 57 patients received FCH1 (n = 29) or MIBI1 (n = 28). The mean (SD) age of patients was 62.8 (12.5) years with 15 male (26%) and 42 female (74%) patients. Baseline patient characteristics were similar between groups. Normocalcemia at 1 month after positive first-line imaging-guided MIP was observed in 23 of 27 patients (85%) in the FCH1 group and 14 of 25 patients (56%) in the MIBI1 group. Sensitivity was 82% (95% CI, 62%-93%) and 63% (95% CI, 42%-80%) for FCH1 and MIBI1, respectively. Follow-up at 6 months with biochemical measures was available in 43 patients, confirming that all patients with normocalcemia at 1 month after surgery still had it at 6 months. No adverse events related to imaging and 4 adverse events related to surgery were reported., Conclusions: This randomized clinical trial found that first-line FCH PET/CT is a suitable and safe replacement for MIBI SPECT/CT. FCH PET/CT leads more patients with PHPT to correct imaging-guided MIP and normocalcemia than MIBI SPECT/CT thanks to its superior sensitivity., Trial Registration: ClinicalTrials.gov Identifier: NCT04040946.

Published
2024
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