8 results on '"Basude M"'
Search Results
2. Venous Supercharging Relieves Venous Congestion and Salvages Gastric Conduit Post-esophagectomy.
- Author
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Yellinedi R, Nuvvula R, Basude M, Kvvn R, Vashisht Y, and Nusrath S
- Abstract
The purpose of this study was to evaluate the effectiveness of incorporating additional venous anastomoses (venous super charging) in improving gastric conduit congestion and preventing complications such as conduit loss and anastomotic leakage following esophagectomy. We included two consecutive patients, one undergoing esophagectomy and the other undergoing laryngo-pharyngo-esophagectomy. Additional venous anastomoses were performed to alleviate venous congestion at the oral end of the gastric conduit. The perfusion assessment of the anastomosis was evaluated using indocyanine green fluorescence angiography (ICG FA) by Stryker's SPY PHI device. Both patients experienced anastomotic leakage, with one having a grade 2 leak and the other a grade 1 leak. Fortunately, conservative measures proved successful in managing these complications and there was no conduit loss. The incorporation of additional venous anastomoses effectively relieves venous congestion in the gastric conduit after esophagectomy and prevent conduit loss, indicating its potential in improving patient outcomes., Competing Interests: Competing InterestsThe authors declare no competing interests., (© The Author(s), under exclusive licence to Indian Association of Surgical Oncology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
- Published
- 2024
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3. Microvascular reconstruction in salvaging the gastric conduit post-esophagectomy after iatrogenic right gastroepiploic vessel injury.
- Author
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Yellinedi R, Nuvvula R, Basude M, Raju KVVN, Vashisht Y, and Nusrath S
- Abstract
The preservation of the right gastroepiploic vessels is essential to ensure proper perfusion of the gastric conduit following esophagectomy. The loss of these vessels can lead to conduit ischemia or necrosis, resulting in significant postoperative complications. Traditional approaches such as colonic or jejunal interposition require extensive surgery and multiple anastomoses. In this report, we present our successful experience of salvaging the gastric tube through microvascular reconstruction following iatrogenic injury to the right gastroepiploic vessels in two cases. The first case involved re-anastomosis of the right gastroepiploic vein, while the second case required reconstruction of both the artery and vein during esophagectomy in a single setting. The procedures were performed by an experienced surgical team using microvascular techniques. Both patients had uneventful postoperative courses without any anastomotic leakage or major complications. Adequate perfusion of the salvaged gastric tube was confirmed intraoperatively using indocyanine green fluorescence perfusion imaging. In conclusion, immediate microvascular reconstruction offers a viable solution by restoring perfusion of the gastric tube in cases of right gastroepiploic vessel injury during esophagectomy., Competing Interests: Competing interestsThe authors declare no financial or non-financial interests that are directly or indirectly related to the work submitted for publication., (© Indian Association of Cardiovascular-Thoracic Surgeons 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
- Published
- 2024
- Full Text
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4. Current status of indocyanine green fluorescent angiography in assessing perfusion of gastric conduit and oesophago-gastric anastomosis.
- Author
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Nusrath S, Kalluru P, Shukla S, Dharanikota A, Basude M, Jonnada P, Abualjadayel M, Alabbad S, Mir TA, Broering DC, Raju K, Rao TS, and Vashist YK
- Subjects
- Humans, Angiography adverse effects, Anastomotic Leak diagnostic imaging, Anastomotic Leak etiology, Anastomosis, Surgical adverse effects, Anastomosis, Surgical methods, Esophagectomy adverse effects, Esophagectomy methods, Perfusion, Indocyanine Green, Coloring Agents
- Abstract
Anastomotic leak (AL) remains a significant complication after esophagectomy. Indocyanine green fluorescent angiography (ICG-FA) is a promising and safe technique for assessing gastric conduit (GC) perfusion intraoperatively. It provides detailed visualization of tissue perfusion and has demonstrated usefulness in oesophageal surgery. GC perfusion analysis by ICG-FA is crucial in constructing the conduit and selecting the anastomotic site and enables surgeons to make necessary adjustments during surgery to potentially reduce ALs. However, anastomotic integrity involves multiple factors, and ICG-FA must be combined with optimization of patient and procedural factors to decrease AL rates. This review summarizes ICG-FA's current applications in assessing esophago-gastric anastomosis perfusion, including qualitative and quantitative analysis and different imaging systems. It also explores how fluorescent imaging could decrease ALs and aid clinicians in utilizing ICG-FA to improve esophagectomy outcomes., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
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5. Factors associated with pathologic complete response following neoadjuvant chemoradiation and esophagectomy for carcinoma of esophagus and gastroesophageal junction.
- Author
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Nusrath S, Thammineedi SR, Raju KVVN, Patnaik SC, Saksena AR, Karthik J, Basude M, Kumar J P, Shukla S, Rao VB, Kumar C K, Gujjuru S, Tewani R, Rushdie T, Sudhir R, Smith LM, and Are C
- Subjects
- Humans, Esophagectomy, Neoadjuvant Therapy, Esophagogastric Junction pathology, Esophageal Neoplasms pathology, Carcinoma, Squamous Cell pathology
- Abstract
Background and Objectives: The aim of this study was to analyze factors associated with pathologic complete response (pCR) following neoadjuvant chemoradiation (NCRT) and esophagectomy for carcinoma of the esophagus (EC) and gastroesophageal junction (GEJ)., Methods: Patients with EC and GEJ tumors who received NCRT and underwent esophagectomy between January 2010 to March 2021 were included. Univariate and multivariate analyses were performed to evaluate the factors associated with pCR by comparing the patients who achieved pCR (pCR group) with those who did not achieve pCR (non-pCR group)., Results: A total of 321 patients were included in the study, with squamous cell carcinoma (SCC) accounting for the majority of cases (76%). One hundred and sixty (49.8%) patients had pCR. SCC histology and pretreatment radiographic node-negative status (cN0) were associated with pCR. Patients in the pCR group had significantly better overall and disease-free survival compared with patients in the non-pCR group., Conclusions: SCC histology and pretreatment radiographic node-negative status were associated with pCR. For patients with tumors of EC and GEJ who received NCRT and underwent esophagectomy, pCR was associated with improved prognosis compared with those not achieving pCR., (© 2022 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.)
- Published
- 2023
- Full Text
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6. Dermal metastases in oral cancer after curative treatment: a single institution cohort study.
- Author
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Chaitanya S A, Kumar A A, Dalakoti P, Basude M, Kumar S, Jonathan GT, Rao TS, Rao S LMCS, and Nemade H
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- Chemotherapy, Adjuvant, Cohort Studies, Humans, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Retrospective Studies, Head and Neck Neoplasms, Mouth Neoplasms pathology, Mouth Neoplasms surgery
- Abstract
Dermal metastasis (DM) is, by definition, the involvement of the skin by cancer cells that originate from cancer elsewhere in the body. The skin is considered a rare site of distant failure in head and neck cancer and DM is the bearer of a poor outcome. Literature about it is limited so this study was undertaken to analyse the factors associated with its incidence and outcomes. A prospectively maintained database on operated cases of oral cancer at a tertiary cancer centre was analysed, and patients who developed dermal metastases during follow up were evaluated. Factors that contributed to early DM and predicted survival after its development were studied. A total of 68 patients (2.8%) had DM as the first presentation of recurrence after a median disease-free period of five months. Early DM was significantly associated with skin involvement by the primary tumour at the time of presentation (p=0.06), extracapsular extension of nodes (p=0.004), and with those who required adjuvant chemotherapy in view of aggressive histology (p=0.021). Median (range) survival after the detection of DM was 97 (5-328) days (3.25 months). Surgical excision of isolated cases was associated with significantly increased survival after detection (p=0.05). Whenever it is feasible without too much morbidity, solitary DM should be excised., (Copyright © 2021 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
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7. Design, synthesis and biological evaluation of selective hybrid coumarin-thiazolidinedione aldose reductase-II inhibitors as potential antidiabetics.
- Author
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Kumar Pasala V, Gudipudi G, Sankeshi V, Basude M, Gundla R, Singh Jadav S, Srinivas B, Yadaiah Goud E, and Nareshkumar D
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- Aldehyde Reductase metabolism, Animals, Cataract prevention & control, Coumarins chemical synthesis, Coumarins metabolism, Coumarins pharmacokinetics, Drug Design, Enzyme Inhibitors chemical synthesis, Enzyme Inhibitors metabolism, Enzyme Inhibitors pharmacokinetics, Hypoglycemic Agents chemical synthesis, Hypoglycemic Agents metabolism, Hypoglycemic Agents pharmacokinetics, Male, Molecular Docking Simulation, Molecular Structure, Protein Binding, Rats, Sprague-Dawley, Structure-Activity Relationship, Thiazolidinediones chemical synthesis, Thiazolidinediones metabolism, Thiazolidinediones pharmacokinetics, Rats, Aldehyde Reductase antagonists & inhibitors, Coumarins therapeutic use, Diabetes Mellitus, Experimental drug therapy, Enzyme Inhibitors therapeutic use, Hypoglycemic Agents therapeutic use, Thiazolidinediones therapeutic use
- Abstract
Thiazolidinediones (TZD), benzopyrans are the proven scaffolds for inhibiting Aldose reductase (ALR2) activity and their structural confluence with the retention of necessary fragments helped in designing a series of hybrid compounds 2-(5-cycloalkylidene-2,4-dioxothiazolidin-3-yl)-N-(2-oxo-2H-chromen-3-yl)acetamide (10a-n) for better ALR2 inhibition. The compounds were synthesized by treating substituted 3-(N-bromoacetyl amino)coumarins (9a-d) with potassium salt of 5-cyclo alkylidene-1,3-thiazolidine-2,4-diones (4a-d). The inhibition activity against ALR2 with IC
50 values range from 0.012 ± 0.001 to 0.056 ± 0.007 μM. N-[(6-Bromo-3-coumarinyl)-2-(5-cyclopentylidene-2,4-dioxothiazolidin-3-yl)] acetamide (10c) with cyclopentylidene group on one end and the 6-bromo group on the other end showed better inhibitory property (IC50 = 0.012 μM) and selectivity index (324.166) against the ALR2, a forty fold superiority over sorbinil, a better molecule over epalrestat and rest of the analogues exhibited a far superior response over sorbinil and slightly better as compared with epalrestat. It was further confirmed by the insilico studies that compound 10c showed best inhibition activity among the synthesized compounds with a high selectivity index against the ALR2. In invivo experiments, supplementation of compound 10c to STZ induced rats delayed the progression of cataract in a dose-dependent manner warranting its further development as a potential agent to treat thediabetic secondary complications especially cataract., (Copyright © 2021 Elsevier Inc. All rights reserved.)- Published
- 2021
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8. Increased recognition of Chryseobacterium species as an emerging cause of nosocomial urinary tract infection following introduction of matrix-assisted laser desorption/ionisation-time of flight for bacterial identification.
- Author
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Kaur H, Mohan B, Hallur V, Raj A, Basude M, Mavuduru RS, and Taneja N
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- Adult, Aged, Chryseobacterium classification, Cluster Analysis, Cross Infection diagnosis, Cross Infection microbiology, Female, Flavobacteriaceae Infections diagnosis, Flavobacteriaceae Infections microbiology, Humans, Male, Middle Aged, Molecular Diagnostic Techniques methods, Molecular Typing, Nephrostomy, Percutaneous, Polymerase Chain Reaction methods, Time Factors, Urinary Tract Infections diagnosis, Urinary Tract Infections microbiology, Urine microbiology, Bacteriological Techniques methods, Chryseobacterium isolation & purification, Cross Infection epidemiology, Diagnostic Tests, Routine methods, Flavobacteriaceae Infections epidemiology, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods, Urinary Tract Infections epidemiology
- Abstract
Chryseobacterium species are rarely reported as aetiological agents of nosocomial urinary tract infection. Here, we evaluated the clinical significance of 19 isolates of Chryseobacterium species (15 Chryseobacterium indologenes and 4 Chryseobacterium gleum; identified by matrix-assisted laser desorption/ionisation-time of flight [MALDI-TOF]) obtained from urine or percutaneous nephrostomy drainage of 16 patients with urological complaints. The strains possessed drug resistance to multiple antibiotics. 14 isolates showed the presence of carbapenemases. Both MALDI-TOF and repetitive sequence-based-polymerase chain reaction grouped them into three clusters (Kappa 1.000). They may colonise the urinary tract acting as a reservoir for dissemination of drug resistance within hospital environment.
- Published
- 2017
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