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6. Changes in Methadone Regulation During COVID-19

Author

Adams, Zoe M., primary, El-Sabawi, Taleed, additional, Coe, William H., additional, Batchelor, Hannah, additional, Wyatt, Janan, additional, Gandhi, Mona, additional, Santana, Ida, additional, and Jordan, Ayana, additional

Published
2023
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14. Structural Adaptations to Methadone Maintenance Treatment and Take-Home Dosing for Opioid Use Disorder in the Era of COVID-19

Author

Suen, Leslie W, Coe, William H, Wyatt, Janan P, Adams, Zoe M, Gandhi, Mona, Batchelor, Hannah M, Castellanos, Stacy, Joshi, Neena, Satterwhite, Shannon, Pérez-Rodríguez, Rafael, Rodríguez-Guerra, Esther, Albizu-Garcia, Carmen E, Knight, Kelly R, and Jordan, Ayana

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Good Health and Well Being, COVID-19, Humans, Methadone, Opiate Substitution Treatment, Opioid-Related Disorders, Medical and Health Sciences, Public Health, Biomedical and clinical sciences, Health sciences
Published
2022

15. Past experience shapes the neural circuits recruited for future learning

Author

Sharpe, Melissa J, Batchelor, Hannah M, Mueller, Lauren E, Gardner, Matthew PH, and Schoenbaum, Geoffrey

Subjects
Neurosciences, Behavioral and Social Science, Mental Health, Underpinning research, 1.2 Psychological and socioeconomic processes, Mental health, Animals, Conditioning, Classical, Cues, Fear, Female, GABAergic Neurons, Hypothalamic Area, Lateral, Learning, Male, Neural Pathways, Rats, Rats, Long-Evans, Rats, Transgenic, Reward, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Experimental research controls for past experience, yet prior experience influences how we learn. Here, we tested whether we could recruit a neural population that usually encodes rewards to encode aversive events. Specifically, we found that GABAergic neurons in the lateral hypothalamus (LH) were not involved in learning about fear in naïve rats. However, if these rats had prior experience with rewards, LH GABAergic neurons became important for learning about fear. Interestingly, inhibition of these neurons paradoxically enhanced learning about neutral sensory information, regardless of prior experience, suggesting that LH GABAergic neurons normally oppose learning about irrelevant information. These experiments suggest that prior experience shapes the neural circuits recruited for future learning in a highly specific manner, reopening the neural boundaries we have drawn for learning of particular types of information from work in naïve subjects.

Published
2021

23. Neurotensin Receptor-1 Identifies a Subset of Ventral Tegmental Dopamine Neurons that Coordinates Energy Balance.

Author

Woodworth, Hillary L, Batchelor, Hannah M, Beekly, Bethany G, Bugescu, Raluca, Brown, Juliette A, Kurt, Gizem, Fuller, Patrick M, and Leinninger, Gina M

Subjects
Ventral Tegmental Area, Animals, Mice, Receptors, Neurotensin, Energy Metabolism, Male, Dopaminergic Neurons, body weight, dopamine, feeding, locomotor activity, mesolimbic, metabolism, neurotensin receptor, nucleus accumbens, obesity, Nutrition, Prevention, Behavioral and Social Science, Basic Behavioral and Social Science, Obesity, Neurosciences, Good Health and Well Being, Biochemistry and Cell Biology, Medical Physiology
Abstract

Dopamine (DA) neurons in the ventral tegmental area (VTA) are heterogeneous and differentially regulate ingestive and locomotor behaviors that affect energy balance. Identification of which VTA DA neurons mediate behaviors that limit weight gain has been hindered, however, by the lack of molecular markers to distinguish VTA DA populations. Here, we identified a specific subset of VTA DA neurons that express neurotensin receptor-1 (NtsR1) and preferentially comprise mesolimbic, but not mesocortical, DA neurons. Genetically targeted ablation of VTA NtsR1 neurons uncouples motivated feeding and physical activity, biasing behavior toward energy expenditure and protecting mice from age-related and diet-induced weight gain. VTA NtsR1 neurons thus represent a molecularly defined subset of DA neurons that are essential for the coordination of energy balance. Modulation of VTA NtsR1 neurons may therefore be useful to promote behaviors that prevent the development of obesity.

Published
2017

25. Combining data on the bioavailability of midazolam and physiologically‐based pharmacokinetic modeling to investigate intestinal CYP3A4 ontogeny.

Author

Johnson, Trevor N., Batchelor, Hannah K., Goelen, Jan, Horniblow, Richard D., and Dinh, Jean

Subjects
*BIOAVAILABILITY, *CYTOCHROME P-450 CYP3A, *MIDAZOLAM, *DRUG bioavailability, *PHARMACOKINETICS, *INTESTINES, *ONTOGENY
Abstract

Pediatric physiologically‐based modeling in drug development has grown in the past decade and optimizing the underlying systems parameters is important in relation to overall performance. In this study, variation of clinical oral bioavailability of midazolam as a function of age is used to assess the underlying ontogeny models for intestinal CYP3A4. Data on midazolam bioavailability in adults and children and different ontogeny patterns for intestinal CYP3A4 were first collected from the literature. A pediatric PBPK model was then used to assess six different ontogeny models in predicting bioavailability from preterm neonates to adults. The average fold error ranged from 0.7 to 1.38, with the rank order of least to most biased model being No Ontogeny < Upreti = Johnson < Goelen < Chen < Kiss. The absolute average fold error ranged from 1.17 to 1.64 with the rank order of most to least precise being Johnson > Upreti > No Ontogeny > Goelen > Kiss > Chen. The optimal ontogeny model is difficult to discern when considering the possible influence of CYP3A5 and other population variability; however, this study suggests that from term neonates and older a faster onset Johnson model with a lower fraction at birth may be close to this. For inclusion in other PBPK models, independent verification will be needed to confirm these results. Further research is needed in this area both in terms of age‐related changes in midazolam and similar drug bioavailability and intestinal CYP3A4 ontogeny. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Colour of Medicines and Children’s Acceptability? A Systematic Literature Review of Children’s Perceptions about Colours of Oral Dosage Forms

Author

Alessandrini, Elisa, primary, Gonakova, Milena, additional, Batchelor, Hannah, additional, Gizurarson, Sveinbjorn, additional, Iurian, Sonia, additional, Klein, Sandra, additional, Schaufelberger, Daniel, additional, Turner, Roy, additional, Walsh, Jennifer, additional, and Tuleu, Catherine, additional

Published
2023
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33. Optimizing expert and patient input in pediatric trial design: Lessons learned and recommendations from a collaboration between conect4children and European Patient‐CEntric ClinicAl TRial PLatforms

Author

Dhaenens, Britt A. E., primary, Mahler, Fenna, additional, Batchelor, Hannah, additional, Dicks, Pamela, additional, Gaillard, Segolene, additional, Nafria, Begonya, additional, Kopp‐Schneider, Annette, additional, Ribeiro, Maria Alexandra, additional, Schwab, Matthias, additional, Sparber‐Sauer, Monika, additional, Leubner, Jonas, additional, de Wildt, Saskia N., additional, and Oostenbrink, Rianne, additional

Published
2023
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36. An investigation into the adhesion of alginate solutions in œsophageal tissue

Author

Batchelor, Hannah

Subjects
615.7
Abstract

Bioadhesive devices have been investigated within the pharmaceutical industry for the past twenty years as a technique to enhance drug bioavailability from localised delivery formulations. Bioadhesive entities have previously been targeted at many sites within the body. This study investigated the feasibility of a liquid bioadhesive system targeted at œsophageal tissue. Such a system has implications in the treatment of gastro-œsophageal reflux disease and also as a novel means of localised drug delivery. Gastro-œsophageal reflux occurs when the acidic contents of the gastric material damage the œsophageal epithelium during reflux episodes. An adhesive alginate layer may enhance the protective systems present within the oesophagus and limit the damage caused by refluxate. Alginates are currently utilised in the management of gastro-œsophageal reflux disease and have also previously been shown to possess bioadhesive potential. This study investigated the interaction between alginate solutions and œsophageal tissue using techniques that allowed assessment on both a macro and microscopic scale. The presence of mucin within the unstirred water layer resident on the œsophageal tissue surface was determined and quantified. The concentration of mucin within the layer was found to be 0.3 % w/v. Rheological studies investigated the interaction between alginate and mucin as well as interactions between alginate and physiologically relevant biological substrates. Rheological synergy is indicative of an adhesive interaction. Synergy was observed in mixed systems of alginate and components of the unstirred water layer. The physico-chemical properties of the alginate were not found to influence the extent of synergy observed. The extent and duration of alginate adhesion on œsophageal tissue was assessed using two techniques; a retention model and microscopy. The results showed that alginate can adhere to œsophageal tissue for periods of at least 60 minutes. The physico-chemical properties of the alginate were not found to influence the retention of the alginate dose.

Published
2001

38. Optimizing expert and patient input in pediatric trial design:Lessons learned and recommendations from a collaboration between conect4children and European Patient-CEntric ClinicAl TRial PLatforms

Author

Dhaenens, Britt A.E., Mahler, Fenna, Batchelor, Hannah, Dicks, Pamela, Gaillard, Segolene, Nafria, Begonya, Kopp-Schneider, Annette, Ribeiro, Maria Alexandra, Schwab, Matthias, Sparber-Sauer, Monika, Leubner, Jonas, de Wildt, Saskia N., Oostenbrink, Rianne, Dhaenens, Britt A.E., Mahler, Fenna, Batchelor, Hannah, Dicks, Pamela, Gaillard, Segolene, Nafria, Begonya, Kopp-Schneider, Annette, Ribeiro, Maria Alexandra, Schwab, Matthias, Sparber-Sauer, Monika, Leubner, Jonas, de Wildt, Saskia N., and Oostenbrink, Rianne

Abstract

Advice from multiple stakeholders is required to design the optimal pediatric clinical trial. We present recommendations for acquiring advice from trial experts and patients/caregivers, derived from advice meetings that were performed through a collaboration of the Collaborative Network for European Clinical Trials for Children (c4c) and the European Patient-CEntric ClinicAl TRial PLatforms (EU-PEARL). Three advice meetings were performed: (1) an advice meeting for clinical and methodology experts, (2) an advice meeting for patients/caregivers, and (3) a combined meeting with both experts and patients/caregivers. Trial experts were recruited from c4c database. Patients/caregivers were recruited through a patient organization. Participants were asked to provide input on a trial protocol, including endpoints, outcomes, and the assessment schedule. Ten experts, 10 patients, and 13 caregivers participated. The advice meetings resulted in modification of eligibility criteria and outcome measures. We have provided recommendations for the most effective meeting type per protocol topic. Topics with limited options for patient input were most efficiently discussed in expert advice meetings. Other topics benefit from patient/caregiver input, either through a combined meeting with experts or a patients/caregivers-only advice meeting. Some topics, such as endpoints and outcome measures, are suitable for all meeting types. Combined sessions profit from synergy between experts and patients/caregivers, balancing input on protocol scientific feasibility and acceptability. Both experts and patients/caregivers provided critical input on the presented protocol. The combined meeting was the most effective methodology for most protocol topics. The presented methodology can be used effectively to acquire expert and patient feedback.

Published
2023

44. Rectal Drug Delivery

Author

Batchelor, Hannah, Crommelin, Daan J. A., Editor-in-chief, Lipper, Robert A., Editor-in-chief, Bar-Shalom, Daniel, editor, and Rose, Klaus, editor

Published
2014
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