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3. Avdoralimab (Anti-C5aR1 mAb) Versus Placebo in Patients With Severe COVID-19: Results From a Randomized Controlled Trial (FOR COVID Elimination [FORCE])*

Author

Carvelli, Julien, Meziani, Ferhat, Dellamonica, Jean, Cordier, Pierre-Yves, Allardet-Servent, Jerome, Fraisse, Megan, Velly, Lionel, Barbar, Saber Davide, Lehingue, Samuel, Guervilly, Christophe, Desgrouas, Maxime, Camou, Fabrice, Piperoglou, Christelle, Vely, Frederic, Demaria, Olivier, Karakunnel, Joyson, Fares, Joanna, Batista, Luciana, Rotolo, Federico, Viotti, Julien, Boyer-Chammard, Agnes, Lacombe, Karine, Le Dault, Erwan, Carles, Michel, Schleinitz, Nicolas, Vivier, Eric, Schleinitz, Nicolas, Carvelli, Julien, Gainnier, Marc, Bourenne, Jérémy, Bichon, Amandine, Le Saux, Audrey, Bouzana, Fouad, Tilmont, Antoine, Cauchois, Emi, Coularet, Charlotte, Bruder, Nicolas, Velly, Lionel, Ebbo, Mikael, Veit, Véronique, Jean, Estelle, Simeone, Pierre, Blasco, Valéry, Vely, Frédéric, Piperoglou, Christelle, Coutard, Bruno, Pastorino, Boris, Villaroel, Maria Saba, Garrido-Pradalie, Emilie, Amichi, Kahéna, Larosa, Aurélie, Blondelon, Aurélie, Inal, Imane, Amichi, Kahéna, Dhorne, Jean, Durieux, Frédérique, Brunet, Julie, Cohen, Anita, Deluca, Bénédicte, Malkoun, Richard, Dellamonica, Jean, Buscot, Matthieu, Saccheri, Clément, Carles, Michel, Demonchy, Elisa, Cua, Eric, Chirio, David, Courjon, Johan, Risso, Karine, Rigault, Marie-Christine, Gazoppi, Loïc, Salas, Virginie, Bouskila, Nadège, Touitou, Irit, Breaud, Sophie, Boughdiri, Nihed, Marrane, Guillaume, Meziani, Ferhat, Merdji, Hamid, Helms, Julie, Monier, Alexandra, Demiselle, Julien, Jandeaux, Louise-Marie, Studer, Antoine, Allam, Hayat, Thiebaut, Léonie, Hutt-Clauss, Anne, Le Dault, Erwan, Cordier, Pierre-Yves, Savini, Hélène, Clerc, Axelle, Spadoni, Sophie, Javelle, Emilie, Clerc, Axelle, Chouaki-Benmansour, Nassima, Le Garlantezec, Patrick, Le Tohic, Sarah, Allardet-Servent, Jérôme, Benarous, Lucas, Madjarian, Corinne, Aouadenne-Mesbah, Assia, Rognon, Amélie, Fraisse, Megan, Plantefeve, Gaétan, Benrezzak, Nasro, Dubief, Emeline, Chauvel, Olivia, Jamet, Charlotte, Davide Barbar, Saber, Ambert, Audrey, Lloret, Sophie, Elotmani, Loubna, Dubois, Grégory, Meyrieux, Séverine, Barthelemi, Laurie, Lehingue, Samuel, Poulet, Antoine, Bezirganyan, Kristina, Asselate, Belkacem, Provitolo, Vincent, Lacombe, Karine, Bollens, Diane, Letaillandier, Cyrielle, Tran, Christian, Sebire, Manuela, Lamarque, Julie, Deguenel-Nguyen, Anne, Desgrouas, Maxime, Jacquier, Sophie, Muller, Grégoire, Bretagnol, Anne, Mathonnet, Armelle, Benzekri, Dalila, Barbier, François, Mai-Anh, Nay, Runge, Isabelle, Kamel, Toufik, Muller, Lucie, Tellec, Sophie, Guervilly, Christophe, Papazian, Laurent, Forel, Jean-Marie, Sanz, Céline, Pinglis, Camille, Valera, Sabine, Colombini, Nathalie, Camou, Fabrice, Mourissoux, Gaelle, Guisset, Olivier, Issa, Nahéma, Pedenon-Peyrichout, Delphine, Delaune, Jean, Langlade, Claire, Pedeboscq, Stéphane, Lescure, Xavier, Isernia, Valentina, Bachelard, Antoine, Fleurot, Odile, Le Gac, Sylvie, Da Conceicao, Olivia, Julia, Zelie, Chalal, Lynda, Oualit, Lynda, Kramer, Laura, Le Grand, Jennifer, Poissy, Julien, Nseir, Saadalla, Mariller, Laure, Delcoutre, Claire, Brice, Sylvie, Lelievre, Jean-Daniel, Gallien, Sébastien, Cotellon, Christine, Vindrios, William, Melica, Giovanna, Natella, Pierre-André, Bourhis, Marion, Thiemele, Alaki, De Nailly, Delphine Lefebvre, Malvy, Denis, Desclaux, Arnaud, Ducours, Mailys, Perreau, Pauline, Boyer, Alexandre, Clouzeau, Benjamin, Bui, Hoang-Nam, Bourgoin, Nicolas, Kabala, Anna, Ghezzoul, Bellabes, Servant, Vincent, and Djabarouti, Sarah

Published
2022
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6. Saúde do Trabalhador

Author

Casseb, Ana Carolina Salim, primary, Casseb, Ana Júlia Salim, additional, Casseb, Ana Letícia Salim, additional, Monteiro, Tiago Araújo, additional, Mesquita, Amanda Holanda de, additional, Oliveira, Pedro Fernandez Fernandes de, additional, Hoyo, Gabriel Trevisan Del, additional, Hoyo, Luisa Trevisan Del, additional, Fernandes, Márcia A, additional, Araújo, Sabrina do Socorro Marques de, additional, Feitosa, Lucíola Galvão Gondim Corrêa, additional, Oliveira, Ana Lívia Castelo Branco de, additional, Tapety, Fabrício Ibiapina, additional, Moura, Luana Kelle Batista, additional, Santos, Letícia Viana dos, additional, Fernandes, Márcia Astrês, additional, Silva, Jaira dos Santos, additional, Oliveira, Adélia Dalva da Silva, additional, MARTINS, MARIA DO CARMO DE CARVALHO E, additional, Alves, Allana Victória Pereira, additional, Cavalcante, Alícia Tenório, additional, Borborema, Andrezza Maria Souza Viana Barreto, additional, Almeida, Ana Beatriz Dantas de, additional, Sousa, Daniela Heitzmann Amaral Valentim de, additional, Oliveira, Gabriel Dias, additional, Silva, Islânia Pacheco da, additional, Macedo, Júlia Tenório Lossio de, additional, Medeiros, Maria Eduarda Moreira Fonsêca, additional, Pereira, Maria Eduarda Coutinho da Franca, additional, Roque, Maria Luiza Teixeira de Carvalho, additional, Teixeira Filho, Paulo Dália, additional, Teixeira, Beatriz Sotéro Oliveira, additional, Sales, Renata Vitoria de Fraça, additional, Moraes, Sabryna Meira Carvalho de, additional, Pereira, Sibely Coelho Urbano, additional, Moura, Maria Lucia Costa de, additional, Azevedo, Suely Lopes de, additional, Alves, Nágila Silva, additional, Silva, Aline Alves da, additional, Homem, Dayla Soeiro, additional, Silva, João Felipe Tinto, additional, CARVALHO, IGOR DE OLIVEIRA, additional, Pereira, Kaliny V dos Santos Alves, additional, Viana, Rycila Thaiana Lima, additional, Mesquita, Nerley P, additional, Portela, Evandro Raimundo Madeira, additional, Oliveira, Maria Bianca de Sousa, additional, Aguiar, Yamane Freire de, additional, Sales Júnior, Romulo de Oliveira, additional, Santos, Carmem Letícia dos, additional, Santos, Maria Doracy dos, additional, Ramiro, Bruna Farias, additional, Machado, Gabriela Luciana, additional, Moreira, Lyslian J A, additional, Brayner, Analine Domingos Rezende, additional, Paes, Annalice Pinheiro, additional, Figueiredo, Camila Oliveira de, additional, Cruz, Elizabeth Fechine, additional, Siqueira, Gabriel Teles de Souza, additional, Torres, Juliana Viana, additional, Lima, Laura de Souza, additional, Nunes, Luana Lócio, additional, Montenegro, Marina Ataide, additional, Golçalves, Monna Myrelle Figueirêdo, additional, Costa, Rayhanna Queiroz de Oliveira, additional, Oliveira, Erick Michell Bezerra, additional, Luz, Aline Cristina Ribeiro da, additional, Ramos, Francisco Iago Sousa, additional, Moura, Manoel Augusto de, additional, Silva, Antônio Izaquiel Campos da, additional, Silva, Roberta Taizar Bezerra, additional, Matos, Rubenilson Luna, additional, Silva, Josienne Araújo da, additional, Pereira, Alan Borba, additional, Marques, Adryanne Larysse F. Rios, additional, Conceição, Domingas Marlyene Silva, additional, Ribeiro, Hernandys, additional, Pereira, Kaliny Vieira dos S. Alves, additional, Santana, Andressa Lorena de Sousa, additional, Oliveira, Angélica Ribeiro do Nascimento, additional, Oliveira, Brian Araujo, additional, Sousa, Francisco Wagner dos Santos, additional, Carvalho, Igor de Oliveira, additional, Sousa, Jaíres Emanuele Nunes de, additional, Oliveira, Jayne Meneses de, additional, Silva, Lucia Emanuele de Sousa, additional, Sousa, Maria Rosa de Lima, additional, Lima, Nadiela F da S, additional, Mesquita, Nerley Pacheco, additional, Almeida, Rayane Oliveira, additional, Carvalho, Rômulo Rangel Leal de, additional, Santos, Beatriz Ferreira dos, additional, Santos, Estéfany Maria Vitória dos, additional, Araújo, Tercília Costa de, additional, Feitosa, Taylinne Santana, additional, Souza, Andressa Maria Silva, additional, Brito, Denise Patrícia Melo de, additional, Conceição, Pedro Wilson Ramos da, additional, Santos, Luiz Henrique Araújo dos, additional, Soares, Sâmia Karina Lima, additional, Sousa Neto, José Gomes de, additional, Sousa, Ulaidia Betânia da Silva, additional, Vieira, Bianca Rodrigues da Silva, additional, Silva, Fabio Cruz da, additional, Silva, José Igor Pereira, additional, Araújo, Zaira Arthemisa Mesquita, additional, Florindo, Natália Monteiro Villela, additional, Florindo, Henrique Donizetti Bianchi, additional, Florindo, Carlos Henrique Bianchi, additional, Seliger, Beatriz Preto Almirall, additional, Vieira, Cláudia Maria da Silva, additional, Alencar, Nadyelle Elias Santos, additional, Carvalho, Mateus Barros Frota de, additional, Costa, Mara J M, additional, Cruz, Ana Luiza de Castro, additional, Silva, Eilane Emanuelle Rodrigues da, additional, Silva, Maria Carolyne Jacauna Oliveira, additional, Sousa, Lara Jennifer da Silva, additional, Fernandes, Letícia Thayane Rodrigues, additional, Mendonça, Déborah Sampaio, additional, Melo, Leonardo Pontes de, additional, Lima, Aline Magalhães de, additional, Ferreira, Ana Beatriz de Oliveira, additional, Queiroz, Géssica Soares, additional, ABREU, KAREN BEATRIZ OLIVEIRA DE, additional, Sousa, Ismaília de Lima, additional, Oliveira, Luciana Karine de Abreu, additional, Cruz, Mateus Ibiapina Vaz de Sousa, additional, Abreu, Karen Beatriz Oliveira de, additional, Costa, Luana Celina da, additional, Vitorino, Jozadake Petry Fausto, additional, Sousa, Caio Pereira de, additional, Araújo, Francisca Giovana Andrade de, additional, Caribé, Valdelice Juliane Alves, additional, Augusto, Pedro Lucas da Fonseca, additional, Lima, Amanda Maria Teixeira Barbosa, additional, Freitas, Karoline Marques da Silva, additional, Sousa, Maria Michele de Resende, additional, Paulo, Sabrina Amorim, additional, Policarpo, Ludymilla Dorneles, additional, Valente, Simoni Suely Chaves, additional, Silva, Regina Lucia dos Reis e, additional, Gabriel, Géssica Vieira de Sousa, additional, Santos, Thaís Oliveira da Silva, additional, Sousa, Geyslla Milleny Kelly Krause de, additional, Carvalho, Kelvisson Rodrigues de, additional, Silva, Ana Carolina de Paula Moura e, additional, Melo, Ana Carolina Gomide Baeta, additional, Sant-Ana, Giovany Martins da Costa, additional, Faria, Gustavo Ribeiro de Petribu, additional, Duarte, Lara Maia, additional, Bueno, Larissa Fernanda Silva, additional, Almeida, Paulo Henrique Figueiredo, additional, Teixeira, Tacyane Neiva Vasconcelos, additional, Gois, Ana Laura, additional, Thomaz, Clara Martins Azevedo Eyer, additional, Ohana, Giovanna Gontijo Alves de Sousa, additional, Silva, Gabriel Sesana da, additional, Belo, Lara Nunes, additional, Milanese, Letícia Luz, additional, Rodrigues, Sávio Soares, additional, MONTEIRO, Júlya de Araujo Silva, additional, PEREIRA, Gicélia Lombardo, additional, PINTO, Cássio Baptista, additional, Guimarães, Clarissa Coelho Vieira, additional, AGUIAR, Beatriz Gerbassi Costa, additional, Souza, Marcella Ribeiro de, additional, Quintiliano, João Augusto Cegarra, additional, Carvalho, Julia Maria Salgado, additional, Leal, Roberta Kayane Silva, additional, Dantas, Rosa Amélia, additional, Costa, Ivy Letícia Brandião, additional, Oliveira, Bárbara Martins Mello de, additional, Costa, Henrique Brandião, additional, Salomão, Vitória Barreto, additional, Cesconetto, Juliana, additional, Nascimento, Maria Luiza Machado do, additional, Morais, Maria Clara M, additional, Xavier, João Vitor Almeida, additional, Martins, Thaynara Guimarães, additional, Neves, Vitória Carvalho, additional, Caldeira Filho, Maurício Lacerda, additional, Nesi, Telma Diniz Bemfica, additional, Heimbecher, Catia Terezinha, additional, Borges, Beatriz E, additional, Campelo, Gabryelly Stephany da Silva, additional, Silva, Denise de Carvalho, additional, Torres, Suellen Caroline Ribeiro, additional, Cavalcante, Lucas Emanoel Matos, additional, Amorim, Jardell Saldanha de, additional, Coêlho, Pammela Gabryelle Pereira, additional, Sousa, Ingrid dos Santos, additional, Sousa, Ana Luíza dos Santos, additional, Costa, Leonardo Freire, additional, Ferreira, Lísia Maria Monteiro, additional, Santos, Jacqueline da Silva, additional, Larivoir, Christina Otaviano Pinto, additional, Alves, Marcelo da Silva, additional, Vieira, Yasmin, additional, Grah, Vitor Matias, additional, Reis, Kalyston Carlos Pereira dos, additional, Bueno, Amanda Soldera de Oliveira, additional, Meneses, Ana Carolina Damázio de, additional, Limberger, Fabiana Gregório, additional, Oliveira, Angélica Silvério, additional, Teodoro, Pietra Thomazini, additional, Sampaio, Ana Luiza Spiassi, additional, Muller, Jéssika Silva, additional, Prado Neto, Maurício, additional, Silva, Ayrthon Lucena da, additional, Bárbara, Débora de Souza, additional, Moreira, Claúdia Maria Dias, additional, Moreira, Victor Hugo Tetilla, additional, Silva, Luan Nilton da, additional, Melo, Maria Carolina Alves Monteiro de, additional, Mahon, Juliana Florêncio, additional, Oliveira, Milena Aguiar Alencar de, additional, Morais, Rafael X B de, additional, Albuquerque, Ana Carolina Magalhães Vasconcelos de, additional, Pacas, Clarissa Machado, additional, Tavares, João F C J, additional, Xavier, Jônatas da Costa, additional, Machado, Maria Carolina Teixeira, additional, Laranjeira, Maria Luiza Florêncio, additional, Lima, Alice Dias Ribeiro de Andrade, additional, Martins, Cintia Medeiros, additional, Assis, Thamires Alcântara Bezerra de, additional, Medeiros, Angela Cristina Rapela, additional, Lago, Pamela Nery do, additional, Andrade, Maria Ivanilde de, additional, Batista, Luciana Moreira, additional, Vieira, Erlon Carlos, additional, Abreu Junior, Ronaldo Antônio de, additional, Carvalho, Andreia Aparecida Martins de, additional, Silva, Edma Nogueira da, additional, Scotton, Veridiana de Oliveira Ursi, additional, Silva, Anderson Fernandes da, additional, Silva, Fabiana Nascimento, additional, Lopes, Samara Oliveira, additional, Fernandes, Marcelo Dangllys Duarte, additional, Santos, Emanoel Rodrigo de Melo Dos, additional, Seixas, Glauber Marcelo Dantas, additional, Costa, Manuela Amaral Almeida, additional, Silva, Amanda Raimundo da, additional, Furbringer, Ariane, additional, Maiochi, Eduarda, additional, Maes, Giulia Veronica Garcia, additional, Bellini, Isabelle, additional, Pinto, Julia Massotti, additional, Bueno, Vitória, additional, Lima, Rita de Cássia Gabrielli Souza, additional, SOUZA, PHELIPE S, additional, Dias, Ana Luiza Vieira, additional, Rocha, Álvaro Sepúlveda Carvalho, additional, Almeida, Daniella Farias, additional, Chaves, Fernanda Raquel Costa, additional, Sousa, Gabriela da Costa, additional, NASCIMENTO, GLÍCIA CARDOSO, additional, Alelaf, Larah Maria Antunes da Silva, additional, Sousa, Luiza Carolinda de, additional, Macedo, Thayná Xavier, additional, Costa, Vitor Hugo da Cunha, additional, Gonçalves, Monna Myrelle Figueirêdo, additional, Luz, Aline Cristina Ribeito, additional, Luz, Aline Cristina Ribeiro, additional, Bezerra, Hernandys Ribeiro, additional, Brito, Denise Patricia de Melo, additional, Santos, Vanessa Freitas dos, additional, and Bezerra, Thais Reis, additional

Published
2021
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7. GERENCIAMENTO DE CONFLITO: INTERFACE ENFERMEIRO E SUA EQUIPE EM UNIDADE DE INTERNAÇÃO HOSPITALAR

Author

Nobre, Valdjane Nogueira Noleto, primary, Lago, Pamela Nery do, additional, Batista, Luciana Moreira, additional, Scarcella, Maria Fernanda Silveira, additional, Seixas, Glauber Marcelo Dantas, additional, Lopes, Samara Oliveira, additional, Costa, Manuela Amaral Almeida, additional, Fróes, Aline Francielly Rezende, additional, Oliveira, Adriano Ferreira de, additional, Silva, Milenny Andreotti e, additional, Anjos, Jéssica de Oliveira dos, additional, and Santos, Milena Vaz Sampaio, additional

Published
2021
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8. SISTEMA DE SAÚDE NORTE-AMERICANO: TRAJETÓRIA HISTÓRIA E OS DESAFIOS PARA O PRESENTE E O FUTURO

Author

Lago, Pamela Nery do, primary, Vieira, Erlon Carlos, additional, Silva, Flávia Cristina Duarte, additional, Batista, Luciana Moreira, additional, Reis, Luciene Maria dos, additional, Silva, Marlene Simões e, additional, Benedito, Regina de Oliveira, additional, Vasconcelos, Andréa Paula Dourado, additional, Marques, Irismar Emília de Moura, additional, Kanashiro, Liane Medeiros, additional, Silva, Lilian Maria Santos, additional, and Costa, Manuela Amaral Almeida, additional

Published
2021
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9. GESTÃO FINANCEIRA HOSPITALAR: OPORTUNIZANDO MELHORIAS

Author

Lago, Pamela Nery do, primary, Corrêa, Camila Ferreira, additional, Silva, Flávia Cristina Duarte, additional, Sipoli, Ira Caroline de Carvalho, additional, Batista, Luciana Moreira, additional, Silva, Marlene Simões e, additional, Cutrim, Diego Leite, additional, Teixeira, Diélig, additional, Seixas, Glauber Marcelo Dantas, additional, Neves, Odaléa Larissa dos Santos, additional, Vera, Samuel Oliveira da, additional, and Souza, Susi dos Santos Barreto de, additional

Published
2021
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10. A INOVAÇÃO COMO IMPORTANTE FERRAMENTA PARA A TOMADA DE DECISÃO ORGANIZACIONAL

Author

Lago, Pamela Nery do, primary, Corrêa, Camila Ferreira, additional, Silva, Denise Karla de Abreu, additional, Silva, Flávia Cristina Duarte, additional, Sipoli, Ira Caroline de Carvalho, additional, Batista, Luciana Moreira, additional, Silva, Marlene Simões e, additional, Cutrim, Diego Leite, additional, Teixeira, Diélig, additional, Albuquerque, Gisela Pereira Xavier, additional, Seixas, Glauber Marcelo Dantas, additional, and Souza, Susi dos Santos Barreto de, additional

Published
2021
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12. GESTÃO DA DIVERSIDADE E AS NOVAS TECNOLOGIAS: UM CENÁRIO DESAFIADOR

Author

Lago, Pamela Nery do, primary, Silva, Flávia Cristina Duarte, additional, Batista, Luciana Moreira, additional, Reis, Luciene Maria dos, additional, Silva, Marlene Simões e, additional, Scarcella, Maria Fernanda Silveira, additional, Benedito, Regina de Oliveira, additional, Nobre, Valdjane Nogueira Noleto, additional, Fróes, Aline Francielly Rezende, additional, Kanashiro, Liane Medeiros, additional, Cruz, Marta Luiza da, additional, and Anaisse, Samanntha Lara da Silva Torres, additional

Published
2021
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14. DESAFIOS ORGANIZACIONAIS: O PAPEL DA GESTÃO EM UM CENÁRIO DE CONSTANTES MUDANÇAS

Author

Lago, Pamela Nery do, primary, Sipoli, Ira Caroline de Carvalho, additional, Batista, Luciana Moreira, additional, Reis, Luciene Maria dos, additional, Silva, Marlene Simões e, additional, Scarcella, Maria Fernanda Silveira, additional, Benedito, Regina de Oliveira, additional, Nobre, Valdjane Nogueira Noleto, additional, Fróes, Aline Francielly Rezende, additional, Kanashiro, Liane Medeiros, additional, Cruz, Marta Luiza da, additional, and Anaisse, Samanntha Lara da Silva Torres, additional

Published
2020
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15. O COMPORTAMENTO HUMANO E SEUS IMPACTOS ORGANIZACIONAIS

Author

Lago, Pamela Nery do, primary, Sipoli, Ira Caroline de Carvalho, additional, Batista, Luciana Moreira, additional, Reis, Luciene Maria dos, additional, Silva, Marlene Simões e, additional, Scarcella, Maria Fernanda Silveira, additional, Benedito, Regina de Oliveira, additional, Nobre, Valdjane Nogueira Noleto, additional, Fróes, Aline Francielly Rezende, additional, Kanashiro, Liane Medeiros, additional, Cruz, Marta Luiza da, additional, and Anaisse, Samanntha Lara da Silva Torres, additional

Published
2020
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19. Large-cell transformation is an independent poor prognostic factor in Sézary syndrome: analysis of 117 cases

Author

Bontoux, Christophe, primary, de Masson, Adèle, additional, Thonnart, Nicolas, additional, Ram-Wolff, Caroline, additional, Caraguel, Flavien, additional, Batista, Luciana, additional, Carpentier, Sabrina, additional, Moins-Teisserenc, Hélène, additional, Rivet, Jacqueline, additional, Vignon-Pennamen, Marie-Dominique, additional, Marie-Cardine, Anne, additional, Bagot, Martine, additional, and Battistella, Maxime, additional

Published
2022
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20. Antitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant

Author

Demaria, Olivier, primary, Gauthier, Laurent, additional, Vetizou, Marie, additional, Blanchard Alvarez, Audrey, additional, Vagne, Constance, additional, Habif, Guillaume, additional, Batista, Luciana, additional, Baron, William, additional, Belaïd, Nourhène, additional, Girard-Madoux, Mathilde, additional, Cesari, Cedric, additional, Caratini, Melody, additional, Bosco, Frédéric, additional, Benac, Olivier, additional, Lopez, Julie, additional, Fenis, Aurore, additional, Galluso, Justine, additional, Trichard, Sylvia, additional, Carrette, Barbara, additional, Carrette, Florent, additional, Maguer, Aurélie, additional, Jaubert, Solène, additional, Sansaloni, Audrey, additional, Letay-Drouet, Robin, additional, Kosthowa, Camille, additional, Lovera, Naouel, additional, Dujardin, Arnaud, additional, Chanuc, Fabien, additional, Le Van, Mélanie, additional, Bokobza, Sivan, additional, Jarmuzynski, Nicolas, additional, Fos, Camille, additional, Gourdin, Nicolas, additional, Remark, Romain, additional, Lechevallier, Eric, additional, Fakhry, Nicolas, additional, Salas, Sébastien, additional, Deville, Jean-Laurent, additional, Le Grand, Roger, additional, Bonnafous, Cécile, additional, Vollmy, Lukas, additional, Represa, Agnès, additional, Carpentier, Sabrina, additional, Rossi, Benjamin, additional, Morel, Ariane, additional, Cornen, Stéphanie, additional, Perrot, Ivan, additional, Morel, Yannis, additional, and Vivier, Eric, additional

Published
2022
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21. Oral Health and Nutritional Status of Semi-Institutionalized Persons with Mental Retardation in Brazil

Author

Batista, Luciana Rodrigues Vieira, Moreira, Emilia Addison Machado, Rauen, Michelle Soares, Corso, Arlete Catarina Tittoni, and Fiates, Giovanna Medeiros Rataichesck

Abstract

Association between oral health status and nutritional status was investigated in 200 semi-institutionalized persons with mental retardation aged 5-53 years, 45.5% female, in the cities of Florianopolis and Sao Jose, province of Santa Catarina, Brazil. In this cross-sectional study, clinical-odontological examination revealed a high percentage of individuals (68%) with heavily compromised dentition. The index of decayed, missing and filled deciduous and permanent teeth, which increased from 2.85 plus or minus 2.87 in children to 20.5 plus or minus 6.86 units in adults, was used to classify the individuals' oral health status. Anthropometric evaluation revealed the prevalence of suboptimal nutritional status in 52% of children and adolescents [22% underweight, 30% at risk of overweight or overweight], and in 60% of adults [7% underweight, 53% overweight or obese]. Significant association was found between unsatisfactory oral health status and overweight in children (chi[superscript 2] = 4.627; p = 0.031). Findings evidenced the existence of a relationship between oral health status and nutritional status in persons with mental retardation. (Contains 3 tables.)

Published
2009
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23. Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

Author

Carvelli, Julien, Demaria, Olivier, Vély, Frédéric, Batista, Luciana, Chouaki Benmansour, Nassima, Fares, Joanna, Carpentier, Sabrina, Thibult, Marie-Laure, Morel, Ariane, Remark, Romain, André, Pascale, Represa, Agnès, Piperoglou, Christelle, Assante Miranda, Laura, Baron, William, Belaid, Nourhène, Caillet, Clarisse, Caraguel, Flavien, Carrette, Barbara, Carrette, Florent, Chanuc, Fabien, Courtois, Rachel, Fenis, Aurore, Giordano, Marilyn, Girard-Madoux, Mathilde, Giraudon-Paoli, Marc, Gourdin, Nicolas, Grondin, Gwendoline, Guillot, Franceline, Habif, Guillaume, Jaubert, Solène, Lopez, Julie, Le Van, Mélanie, Lovera, Naouel, Mansuy, Marine, Bonnet, Elodie, Sansaloni, Audrey, Reboul, Annick, Mitry, Emmanuel, Nekkar-Constant, Camille, Péri, Valentine, Ricaut, Paul, Simon, Léa, Vallier, Jean-Baptiste, Vétizou, Marie, Zerbib, Robert, Ugolini, Sophie, Etiennot, Marion, Galluso, Justine, Lyonnet, Luc, Forel, Jean-Marie, Papazian, Laurent, Velly, Lionel, André, Baptiste, Briantais, Antoine, Faucher, Benoit, Jean, Estelle, Seguier, Julie, Veit, Veronique, Harlé, Jean-Robert, Pastorino, Boris, Delteil, Clémence, Daniel, Laurent, Boudsocq, Jean-Paul, Clerc, Axelle, Delmond, Emmanuel, Vidal, Pierre-Olivier, Savini, Hélène, Coutard, Bruno, Cordier, Pierre Yves, Le Dault, Erwan, Guervilly, Christophe, Simeone, Pierre, Gainnier, Marc, Morel, Yannis, Ebbo, Mikael, Schleinitz, Nicolas, and Vivier, Eric

Subjects
0301 basic medicine, Acute Lung Injury, Complement C5a, Inflammation, Complement factor I, Lung injury, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Animals, Humans, Myeloid Cells, Lung, Receptor, Anaphylatoxin C5a, Respiratory Distress Syndrome, CD11b Antigen, Multidisciplinary, medicine.diagnostic_test, SARS-CoV-2, business.industry, COVID-19, respiratory system, Pathophysiology, 3. Good health, Complement system, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Female, medicine.symptom, Cytokine Release Syndrome, business, Bronchoalveolar Lavage Fluid
Abstract

Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role in the initiation and maintenance of several inflammatory responses by recruiting and activating neutrophils and monocytes1. Here we provide a longitudinal analysis of immune responses, including phenotypic analyses of immune cells and assessments of the soluble factors that are present in the blood and bronchoalveolar lavage fluid of patients at various stages of COVID-19 severity, including those who were paucisymptomatic or had pneumonia or acute respiratory distress syndrome. The levels of soluble C5a were increased in proportion to the severity of COVID-19 and high expression levels of C5aR1 receptors were found in blood and pulmonary myeloid cells, which supports a role for the C5a-C5aR1 axis in the pathophysiology of acute respiratory distress syndrome. Anti-C5aR1 therapeutic monoclonal antibodies prevented the C5a-mediated recruitment and activation of human myeloid cells, and inhibited acute lung injury in human C5aR1 knock-in mice. These results suggest that blockade of the C5a-C5aR1 axis could be used to limit the infiltration of myeloid cells in damaged organs and prevent the excessive lung inflammation and endothelialitis that are associated with acute respiratory distress syndrome in patients with COVID-19.

Published
2020
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25. Erradicação do trabalho infantil nos fluxos migratórios do Mercosul: desafios e perspectivas = Eradication of child labor in Mercosur migratory flows: challenges and perspectives = Erradicación del trabajo infantil en el Mercosur flujos migratorios: desafíos y perspectivas

Author

Arakaki, Ingrid Luize Bonadiman, Batista, Luciana da Silva Vilela, and Félix, Ynes da Silva

Abstract

Submitted by phemiran@stj.jus.br (phemiran@stj.jus.br) on 2022-08-05T19:56:58Z No. of bitstreams: 2 7.erradicacao_trabalho_infantil_arakaki.pdf: 332461 bytes, checksum: 330e3e53978ea255a46f6355f3507ba3 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on 2022-08-08T17:31:46Z (GMT) No. of bitstreams: 2 7.erradicacao_trabalho_infantil_arakaki.pdf: 332461 bytes, checksum: 330e3e53978ea255a46f6355f3507ba3 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Made available in DSpace on 2022-08-08T17:31:46Z (GMT). No. of bitstreams: 2 7.erradicacao_trabalho_infantil_arakaki.pdf: 332461 bytes, checksum: 330e3e53978ea255a46f6355f3507ba3 (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Previous issue date: 2022 DOI: https://doi.org/10.30612/ videre.v14i19.14896

Published
2022

26. Avdoralimab (anti-C5aR1 mAb) Versus Placebo in Patients With Severe COVID-19: Results From a Randomized Controlled Trial (FORCE)

Author

Carvelli, Julien, primary, Meziani, Ferhat, additional, Dellamonica, Jean, additional, Cordier, Pierre-Yves, additional, Allardet-Servent, Jerome, additional, Fraisse, Megan, additional, Velly, Lionel, additional, Barbar, Saber, additional, Lehingue, Samuel, additional, Guervilly, Christophe, additional, Desgrouas, Maxime, additional, Camou, Fabrice, additional, Piperoglou, Christelle, additional, Vely, Frederic, additional, Zerbib, Robert, additional, Mitry, Emmanuel, additional, Karakunnel, Joyson, additional, Fares, Joanna, additional, Batista, Luciana, additional, Rotolo, Federico, additional, Viotti, Julien, additional, Boyer-Chammard, Agnès, additional, Carpentier, Sabrina, additional, Demaria, Olivier, additional, Lacombe, Karine, additional, Le Dault, Erwan, additional, Chouaki-Benmansour, Nassima, additional, Carles, michel, additional, Schleinitz, Nicolas, additional, Vivier, Eric, additional, and Group, The Force Study, additional

Published
2022
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27. Decentralization and Humanization of Public Health Services

Author

e Silva, Marlene Simões, primary, do Lago, Pamela Nery, additional, Pinto, Carolina Costa, additional, Mendes, Renata Castro, additional, Lisboa, Luciana de Morais, additional, Rodrigues, Ronaldo Gomes, additional, Pereira, Ana Paula Caetano, additional, Batista, Luciana Moreira, additional, Nascimento, Andréia Elias da Cruz, additional, Freitas, Pablo Raphael de, additional, Santos, Merilaine Isabel dos, additional, Santos, Carla Renata dos, additional, Costa, Karine Letícia de Araújo, additional, Paula, Marília Antônia de, additional, Saturnino, Danielle Cristina de Oliveira Silva, additional, Carvalho, Liene de Fátima, additional, Menezes, Nicolle Silva de, additional, Miranda, Flávia Lima, additional, Penna, Aline Borges, additional, Duarte, Maria Emília Lúcio, additional, e Silva, Raquel Resende Cabral de Castro, additional, Araújo, Mariângela Ferraz Rodrigues, additional, Amorim, Hirlla Karla de, additional, Franzoi, Kiwisunny Galvão, additional, Braga, Fabiana Ribeiro da Silva, additional, Araújo, Ana Paula Ferreira Marques de, additional, Amorim, Hilma Keylla de, additional, Ventura, Luzimare de Matos Avelino, additional, Silva, Darlan dos Santos Damásio, additional, Golfetto, Juliane Guerra, additional, Nascimento, Leticia do, additional, Fernandes, Marcelo Dangllys Duarte, additional, Guimarães, Rafaela Bezerra Gama, additional, Andrade, Maria Ivanilde de, additional, Silva, Leonardo Oliveira, additional, Silva, Michelly Angelina Lazzari da, additional, Oliveira, Diva Maria de, additional, Anaisse, Samanntha Lara da Silva Torres, additional, Alexandre, Juliana Grazielle Lobato, additional, Bortoluzi, Eugênio Barros, additional, Costa, Fernando Henrique da Silva, additional, Oliveira, Luciana Latorre Galves, additional, Jesus, Walter Guimarães de, additional, Albuquerque, Gisela Pereira Xavier, additional, Rodrigues, Siomara Jesuina de Abreu, additional, Freitas, Cijara Leonice de, additional, Silva, Raiane Almeida, additional, Campos, Andressa Caline Inácio Natalino, additional, Campos, Eliseu da Costa, additional, Barboza, Edmilson Escalante, additional, Kanashiro, Liane Medeiros, additional, and Costa, Tatiana Alves, additional

Published
2022
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28. The difficulties of implementing palliative care

Author

Araújo, Mariângela Ferraz Rodrigues, primary, Santos, Ana Paula Saldanha, additional, Amorim, Andressa Jordânia Alves de, additional, Walder, Francielly Aparecida Lemos, additional, Pisani, Ivan Paioletti, additional, Gouvea, Thalyta Eduarda de Menezes, additional, Oliveira, Bruna Rafaela Gomes de Sousa, additional, Lago, Pamela Nery do, additional, Freitas, Simone Aparecida de Souza, additional, Batista, Luciana Moreira, additional, Saturnino, Danielle Cristina de Oliveira Silva, additional, Lisboa, Luciana de Morais, additional, Fernandes, Aline da Silva, additional, Oliveira, Diva Maria de, additional, Pinto, Carolina Costa, additional, Rezende, Elessandra Antônia Santos de, additional, Menezes, Nicolle Silva de, additional, Pereira, Ana Paula Caetano, additional, Rodrigues, Ronaldo Gomes, additional, Padovani, Fabíola Fontes, additional, Costa, Laiana Otto da, additional, Silva, Raquel Resende Cabral de Castro e, additional, Ninditi, Ângelo Aparecido, additional, Pinho, João Eduardo, additional, Duarte, Maria Emília Lúcio, additional, Silva, Darlan dos Santos Damásio, additional, Golfetto, Juliane Guerra, additional, Nascimento, Leticia do, additional, Sales, Rita de Cássia Almeida, additional, Franzoi, Kiwisunny Galvão, additional, Amorim, Hirlla Karla de, additional, Fontes, Kelly Monte Santo, additional, Guimarães, Rafaela Bezerra Gama, additional, Silva, Fabiana Nascimento, additional, Fernandes, Marcelo Dangllys Duarte, additional, Silva, Lisyanne Pinheiro Costa, additional, Amorim, Hilma Keylla de, additional, Silva, Tatiana Lamounier, additional, Silva, Leonardo Oliveira, additional, Silva, Michelly Angelina Lazzari da, additional, Silva, Edma Nogueira da, additional, Cruz, Ana Patrícia da, additional, Costa, Tatiana Alves, additional, Silva, Raiane Almeida, additional, Santos, Ana Luiza Loiola, additional, Alexandre, Juliana Grazielle Lobato, additional, Costa, Fernando Henrique da Silva, additional, Bortoluzi, Eugênio Barros, additional, Andrade, Maria Ivanilde de, additional, Lazzari, Daniel da Silva Costa, additional, Alonso, Claudiomiro da Silva, additional, Silva, Daniele Estéfany de Souza Pires, additional, and Quintela, Andrea de Sousa, additional

Published
2022
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30. 851 Harnessing innate immunity in cancer therapies: the example of natural killer cell engagers

Author

Demaria, Olivier, primary, Vivier, Eric, additional, Vetizou, Marie, additional, Alvarez, Audrey Blanchard, additional, Habif, Guillaume, additional, Bonnafous, Cécile, additional, Bokobza, Sivan, additional, Represa, Agnès, additional, Rossi, Benjamin, additional, Batista, Luciana, additional, Vagne, Constance, additional, Carpentier, Sabrina, additional, Cornen, Stéphanie, additional, Morel, Ariane, additional, Perrot, Ivan, additional, Morel, Yannis, additional, and Gauthier, Laurent, additional

Published
2021
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32. Nursing dialogues during the pandemic: reflections, challenges and perspectives for teaching-service integration

Author

Spagnol, Carla Aparecida, Pereira, Karolinna Diniz, Castro, Verônica Pedersane Nunes de, Figueiredo, Letícia Gonçalves, Borges, Karine Karoline de Souza, and Batista, Luciana Moreira

Subjects
Nursing course, Enfermagem, Serviços de Saúde, Curso de Enfermería, Nursing, Serviços de Integração Docente-Assistencial, Health services, Coronavírus, Coronavirus, Teaching Care Integration Services, Servicios de Integración Docente Asistencial, Enfermería, Servicios de salud, Curso de Enfermagem
Abstract

Resumo Objetivo abordar, de forma crítica e reflexiva, desafios e perspectivas da prática profissional da enfermagem, da formação e da integração ensino-serviço no cenário da pandemia da Covid-19. Método as atividades práticas de uma disciplina, que aborda a gestão do Sistema Único de Saúde, foram suspensas durante a pandemia. Diante desse fato, constituiu-se um grupo para discutir a prática profissional, assegurando a integração ensino-serviço. A partir dos diálogos e dos textos produzidos elaborou-se essa reflexão, tendo como referencial teórico a Análise Institucional. Resultados alguns analisadores revelaram desafios como a influência e o difícil acesso às tecnologias digitais no ensino e no processo de trabalho, além do medo e da insegurança vivenciados pelas autoras. O grupo analisou suas implicações, compartilhando sentimentos e angústias, sem perder de vista as mudanças necessárias nos processos de trabalho. Conclusão e implicações para a prática a Análise Institucional contribuiu para realizar este estudo “à quente”, nesse contexto de pandemia, trazendo à tona questionamentos e contradições vivenciadas nos serviços de saúde e na universidade, fortalecendo a integração ensino-serviço. Mas, mediante o recorte de tempo, práticas e cenários este estudo traz limitações quanto aos impactos para o ensino e para a assistência prestada, possibilitando a realização de outras pesquisas. Resumen Objetivo abordar de manera crítica y reflexiva, los desafíos y perspectivas de la práctica profesional de enfermería, de la formación y la integración enseñanza-servicio en el escenario de la pandemia Covid-19. Método las actividades prácticas de una disciplina, que aborda la gestión del Sistema Único de Salud, fueron suspendidas durante la pandemia. Ante este hecho, se formó un grupo para discutir la práctica profesional, asegurando la integración entre enseñanza y servicio. A partir de los diálogos y textos producidos, se elaboró esta reflexión, teniendo como marco teórico el Análisis Institucional. Resultados algunos analizadores revelaron desafíos como la influencia y el difícil acceso a las tecnologías digitales en la enseñanza y en el proceso de trabajo, además del miedo y la inseguridad vivenciados por las autoras. El grupo analizó sus implicaciones, compartiendo sentimientos y ansiedades, sin perder de vista los cambios necesarios en los procesos de trabajo. Conclusión e implicaciones para la práctica El Análisis Institucional contribuyó a realizar este estudio “en caliente”, en este contexto de pandemia, planteando interrogantes y contradicciones vividas en los servicios de salud y en la universidad, fortaleciendo la integración enseñanza -servicio. Pero, a través del recorte de tiempo, prácticas y escenarios, este estudio trae limitaciones en cuanto a los impactos para la enseñanza y la asistencia brindada, permitiendo la realización de otras investigaciones. Abstract Objective critically and reflexively address challenges and perspectives of professional nursing practice, training, and teaching-service integration in the context of the Covid-19 pandemic. Method the practical activities of a discipline that addresses the management of the Unified Health System were suspended during the pandemic. In view of this fact, a group was formed to discuss the professional practice, ensuring the teaching-service integration. From the dialogues and texts produced, this reflection was elaborated, using Institutional Analysis as a theoretical framework. Results some analyzers revealed challenges such as the influence and difficult access to digital technologies in teaching and in the work process, as well as the fear and insecurity experienced by the authors. The group analyzed their implications, sharing feelings and anguish, without losing sight of the necessary changes in the work processes. Conclusion and implications for the practice the Institutional Analysis contributed to carry out this study “in the heat of the moment”, in this pandemic context, bringing to light questions and contradictions experienced in health services and in the university, strengthening the teaching-service integration. But, due to the cut-off of time, practices and scenarios, this study has limitations regarding the impacts on teaching and the care provided, making it possible to carry out other research.

Published
2021

33. miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

Author

Mateescu, Bogdan, Batista, Luciana, Cardon, Melissa, Gruosso, Tina, de Feraudy, Yvan, Mariani, Odette, Nicolas, Andre, Meyniel, Jean-Philippe, Cottu, Paul, Sastre-Garau, Xavier, and Mechta-Grigoriou, Fatima

Subjects
Physiological aspects, Research, MicroRNA -- Research -- Physiological aspects, Ovarian tumors -- Research -- Physiological aspects, Oxidative stress -- Research -- Physiological aspects
Abstract

Epithelial ovarian cancer is the most lethal form of gynecologic malignancy. The clinical prognosis factors for this type of cancer are based on the state of the disease at diagnosis, [...], Although there is evidence that redox regulation has an essential role in malignancies, its impact on tumor prognosis remains unclear. Here we show crosstalk between oxidative stress and the miR-200 family of microRNAs that affects tumorigenesis and chemosensitivity. miR-141 and miR-200a target p38a and modulate the oxidative stress response. Enhanced expression of these microRNAs mimics p38a deficiency and increases tumor growth in mouse models, but it also improves the response to chemotherapeutic agents. High-grade human ovarian adenocarcinomas that accumulate miR-200a have low concentrations of p38α and an associated oxidative stress signature. The miR200a-dependent stress signature correlates with improved survival of patients in response to treatment. Therefore, the role of miR-200a in stress could be a predictive marker for clinical outcome in ovarian cancer. In addition, although oxidative stress promotes tumor growth, it also sensitizes tumors to treatment, which could account for the limited success of antioxidants in clinical trials.

Published
2011
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34. Diálogos da enfermagem durante a pandemia: reflexões, desafios e perspectivas para a integração ensino-serviço

Author

Spagnol,Carla Aparecida, Pereira,Karolinna Diniz, Castro,Verônica Pedersane Nunes de, Figueiredo,Letícia Gonçalves, Borges,Karine Karoline de Souza, and Batista,Luciana Moreira

Subjects
Coronavírus, Enfermagem, Serviços de Saúde, Serviços de Integração Docente-Assistencial, Curso de Enfermagem
Abstract

Resumo Objetivo abordar, de forma crítica e reflexiva, desafios e perspectivas da prática profissional da enfermagem, da formação e da integração ensino-serviço no cenário da pandemia da Covid-19. Método as atividades práticas de uma disciplina, que aborda a gestão do Sistema Único de Saúde, foram suspensas durante a pandemia. Diante desse fato, constituiu-se um grupo para discutir a prática profissional, assegurando a integração ensino-serviço. A partir dos diálogos e dos textos produzidos elaborou-se essa reflexão, tendo como referencial teórico a Análise Institucional. Resultados alguns analisadores revelaram desafios como a influência e o difícil acesso às tecnologias digitais no ensino e no processo de trabalho, além do medo e da insegurança vivenciados pelas autoras. O grupo analisou suas implicações, compartilhando sentimentos e angústias, sem perder de vista as mudanças necessárias nos processos de trabalho. Conclusão e implicações para a prática a Análise Institucional contribuiu para realizar este estudo “à quente”, nesse contexto de pandemia, trazendo à tona questionamentos e contradições vivenciadas nos serviços de saúde e na universidade, fortalecendo a integração ensino-serviço. Mas, mediante o recorte de tempo, práticas e cenários este estudo traz limitações quanto aos impactos para o ensino e para a assistência prestada, possibilitando a realização de outras pesquisas.

Published
2021

35. Unveiling the meaning attributed to nursing care at the perspective of person with cancer

Author

Martins, Wenderson Melo, primary, Oliveira, Joelia dos Santos, additional, de Matos, Maria Caroline Barros, additional, da Silva, Samara Barbosa, additional, Silva Souza, Rúbia Caroline, additional, Porfírio Mendes, Clarissa, additional, Albuquerque, Gisela Pereira Xavier, additional, Miranda, Sheila do Socorro dos Santos, additional, Ribeiro, Juliane Conceição Costa, additional, Leão Fayal, Yasmim, additional, Bender, Hermana Rayanne Lucas de Andrade, additional, da Silveira, Marcilene Souza, additional, Pinheiro, Gabriela Nunes, additional, da Silva, Maria Liduina Melo, additional, Pinto, Viviane, additional, Pereira, Eliane de Brito, additional, Mesquita Maia, Bruno, additional, Camboim, Bianca Blois Pinheiro, additional, Antunes, Suane Priscila dos Santos, additional, Andrade, Darllene Lucas de, additional, da Vera, Samuel Oliveira, additional, de Lima, Cláudia Rafaela Brandão, additional, da Silva, Camila Melo, additional, Lins, Marcio Almeida, additional, Santo, Leliane do Nascimento do Espírito, additional, Junior, Eimar Neri de Oliveira, additional, Favacho, Vanessa de Nazaré Mendes, additional, Almeida, Lucilena Estumano, additional, da Costa, Jamyle Guedes, additional, Seixas, Glauber Marcelo Dantas, additional, dos Santos, Emerson Glauber Abreu, additional, Carvalho, Izabel Silva, additional, Medeiros, Tania de Sousa Pinheiro, additional, e Silva, Marlene Simões, additional, Benedito, Regina de Oliveira, additional, Duarte Silva, Flávia Cristina, additional, Abreu Silva, Denise Karla de, additional, Maciel, Danielle Oliveira, additional, Batista, Luciana Moreira, additional, Borges, Renata Campos de Sousa, additional, Franco, Fabricia de Sousa, additional, Melo Matos, Everson Vando, additional, Amador, Emmily Oliveira, additional, de Lima, Enderson Vasconcelos, additional, da Silva, Edma Nogueira, additional, Rodrigues, Karina Raissa, additional, Franco, Alex Miranda, additional, Camacho, Elyade Nelly Pires Rocha, additional, Camacho, Fabio Feitosa, additional, Prestes, Raimunda de Fátima Carvalho, additional, Oliveira, Tatyellen Natasha da Costa, additional, Santos, Anderson Lineu Siqueta dos, additional, Figueira, Simone Aguiar da Silva, additional, Nogueira, Maicon de Araujo, additional, Freitas, Jofre Jacob da Silva, additional, and Moita Sá, Antonia Margareth, additional

Published
2021
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37. 483 Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis

Author

Demaria, Olivier, primary, Carvelli, Julien, additional, Benmansour, Nassima Chouaki, additional, Fares, Joanna, additional, Batista, Luciana, additional, Thibult, Marie-Laure, additional, Morel, Ariane, additional, Carpentier, Sabrina, additional, Remark, Romain, additional, Represa, Agnes, additional, Vely, Frederic, additional, Ebbo, Mikael, additional, Schleinitz, Nicolas, additional, Zerbib, Robert, additional, Morel, Yannis, additional, Vivier, Eric, additional, and Demaria, Olivier, additional

Published
2020
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38. Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer

Author

Marliot, Florence, primary, Chen, Xiaoyi, additional, Kirilovsky, Amos, additional, Sbarrato, Thomas, additional, El Sissy, Carine, additional, Batista, Luciana, additional, Van den Eynde, Marc, additional, Haicheur-Adjouri, Nacilla, additional, Anitei, Maria-Gabriela, additional, Musina, Ana-Maria, additional, Scripcariu, Viorel, additional, Lagorce-Pagès, Christine, additional, Hermitte, Fabienne, additional, Galon, Jérôme, additional, Fieschi, Jacques, additional, and Pagès, Franck, additional

Published
2020
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40. Wastewater reuse: a legal analysis of the possibilities and challenges for the agroindustrial sector of Sousa - PB

Author

BATISTA, Luciana Marques de Oliveira., VIEIRA, Allan Sarmento., MARACAJÁ, Patrício Borges., PEREIRA JUNIOR, Ednaldo Barbosa., and MARQUES, Jacyara Farias Souza.

Subjects
Engenharia Sanitária, Setor agroindustrial, Water reuse - legislation, Alternativa sustentável, Agroindustrial sector, Sustainable alternative, Effluents, Reúso de água - legislação, Efluentes
Abstract

Submitted by JOELMA NASCIMENTO (joelma_goldmann@hotmail.com) on 2019-07-11T12:12:29Z No. of bitstreams: 1 LUCIANA MARQUES DE OLIVEIRA BATISTA - ARTIGO - PPGSA - PROFISSIONAL 2019.pdf: 1087184 bytes, checksum: 1cb557cedd9f47d3d05b449c3f3f022b (MD5) Made available in DSpace on 2019-07-11T12:12:29Z (GMT). No. of bitstreams: 1 LUCIANA MARQUES DE OLIVEIRA BATISTA - ARTIGO - PPGSA - PROFISSIONAL 2019.pdf: 1087184 bytes, checksum: 1cb557cedd9f47d3d05b449c3f3f022b (MD5) Previous issue date: 2019-05-20 Este artigo trata de uma análise legal das possibilidades e desafios a respeito do reúso de água residual no setor agroindustrial de Sousa – PB, como alternativa sustentável para minimizar os impactos da crise hídrica. A respeito da temática dispõe a Lei nº 9.433/97 denominada de Política Nacional de Recursos Hídricos (PNRH), a Resolução de nº 54/2005 do Conselho Nacional de Recursos Hídricos (CNRH) e demais normas gerais. Nesse sentido, o objetivo é analisar a existência de regulamentação legal no âmbito local, para implantação do sistema de reúso de água residual nos empreendimentos agroindustriais acompanhada por incentivo social, econômico e ambiental. A pesquisa parte da hipótese de que, no Brasil, a legislação que trata de reúso de água é insuficiente para torná-lo medida acessível de uso racional e eficiente de água, porém, o município está autorizado nos moldes do art. 30, inciso I da Constituição Federal de 1988 (CF/88) para legislar sobre assuntos de interesse local, mediante lei especifica. Para tanto, a pesquisa tem cunho exploratório e dedutivo, além de ser descritiva. Os resultados mostram que a implantação da prática de reúso de água residual torna-se viável para o município, tendo em vista a competência do ente local prevista constitucionalmente. Some-se também as construções teóricas que destacam a viabilidade desse mecanismo, além de vários exemplos já implantados no Brasil e em outros países, como os Estados Unidos e Israel, além dessa prática ser considerada segundo relatório da UNESCO de 2017 como uma tendência global. This article deals with a legal analysis of the possibilities and challenges regarding residual water reuse in the Sousa – PB agroindustrial sector, as a sustainable alternative to minimize the impacts of the water crisis. Regarding this issue, Law No. 9,433 / 97 called the National Policy on Water Resources (PNRH), Resolution No. 54/2005 of the National Water Resources Council (CNRH) and other general standards. In this sense, the objective is to analyze the existence of legal regulations at the local level, to implement the wastewater reuse system in agroindustrial enterprises accompanied by social, economic and environmental incentive. The research starts from the hypothesis that, in Brazil, the legislation that deals with water reuse is insufficient to make it an accessible measure of rational and efficient use of water; however, the municipality authorized in the mold of art. 30, item I of the Federal Constitution of 1988 (CF / 88) to legislate on matters of local interest, by means of a specific law. For this, the research has an exploratory and deductive nature, besides being descriptive. The results show that the implementation of the practice of wastewater reuse becomes feasible for the municipality, considering the jurisdiction of the local entity envisaged constitutionally. There are also theoretical constructions that highlight the viability of this mechanism, in addition to several examples already implemented in Brazil and in other countries, such as the United States and Israel, besides this practice considered according to UNESCO's report of 2017 as a global trend.

Published
2019

41. Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer.

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, Marliot, Florence, Chen, Xiaoyi, Kirilovsky, Amos, Sbarrato, Thomas, El Sissy, Carine, Batista, Luciana, Van Den Eynde, Marc, Haicheur-Adjouri, Nacilla, Anitei, Maria-Gabriela, Musina, Ana-Maria, Scripcariu, Viorel, Lagorce-Pagès, Christine, Hermitte, Fabienne, Galon, Jérôme, Fieschi, Jacques, Pagès, Franck, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, Marliot, Florence, Chen, Xiaoyi, Kirilovsky, Amos, Sbarrato, Thomas, El Sissy, Carine, Batista, Luciana, Van Den Eynde, Marc, Haicheur-Adjouri, Nacilla, Anitei, Maria-Gabriela, Musina, Ana-Maria, Scripcariu, Viorel, Lagorce-Pagès, Christine, Hermitte, Fabienne, Galon, Jérôme, Fieschi, Jacques, and Pagès, Franck

Abstract

BACKGROUND: New and fully validated tests need to be brought into clinical practice to improve the estimation of recurrence risk in patients with colon cancer. The aim of this study was to assess the analytical performances of the Immunoscore (IS) and show its contribution to prognosis prediction. METHODS: Immunohistochemical staining of CD3+ and CD8+ T cells on adjacent sections of colon cancer tissues were quantified in the core of the tumor and its invasive margin with dedicated IS modules integrated into digital pathology software. Staining intensity across samples collected between 1989 and 2016 (n=595) was measured. The accuracy of the IS workflow was established by comparing optical and automatic counts. Analytical precision of the IS was evaluated within individual tumor block on distant sections and between eligible blocks. The IS interlaboratory reproducibility (n=100) and overall assay precision were assessed (n=3). Contribution of the IS to prediction of recurrence based on clinical and molecular parameters was determined (n=538). RESULTS: Optical and automatic counts for CD3+ or CD8+ were strongly correlated (r=0.94, p<0.001 and r=0.92, p<0.001, respectively). CD3 and CD8 staining intensities were not altered by the age of the tumor block over a period of 30 years. Neither the position of tested tissue sections within a tumor block nor the selection of the tissue blocks affected the IS. Reproducibility of the IS was not affected by multiple variables (eg, antibody lots, DAB revelation kits, immunohistochemistry automates and operators). Interassay repeatability of the IS was 100% and interlaboratory reproducibility between two testing centers was 93%. Finally, in a case series of patients with stage II-III colon cancer, the relative proportion of variance for time to recurrence was greatest for the IS (53% of prognostic variability) in a model that included IS, T-stage, microsatellite instability status and total number of lymph nodes. CONCLUSION: IS is

Published
2020

42. DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification.

Author

Decamps, Clémentine, Arnaud, Alexis, Petitprez, Florent, Ayadi, Mira, Baurès, Aurélia, Armenoult, Lucile, HADACA consortium, Alcala, N., Arnaud, A., Avila Cobos, F., Batista, Luciana, Batto, A.-F., Blum, Y., Chuffart, F., Cros, J., Decamps, C., Dirian, L., Doncevic, D., Durif, G., and Bahena Hernandez, S. Y.

Subjects
HETEROGENEITY, CANCER invasiveness, TRANSCRIPTOMES, DECONVOLUTION (Mathematics), MEDICAL sciences, SOURCE code
Abstract

Background: Quantification of tumor heterogeneity is essential to better understand cancer progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to assess the different cell populations from single-omic datasets as bulk transcriptome or methylome samples have been recently developed, including reference-based and reference-free methods. Improved methods using multi-omic datasets are yet to be developed in the future and the community would need systematic tools to perform a comparative evaluation of these algorithms on controlled data. Results: We present DECONbench, a standardized unbiased benchmarking resource, applied to the evaluation of computational methods quantifying cell-type heterogeneity in cancer. DECONbench includes gold standard simulated benchmark datasets, consisting of transcriptome and methylome profiles mimicking pancreatic adenocarcinoma molecular heterogeneity, and a set of baseline deconvolution methods (reference-free algorithms inferring cell-type proportions). DECONbench performs a systematic performance evaluation of each new methodological contribution and provides the possibility to publicly share source code and scoring. Conclusion: DECONbench allows continuous submission of new methods in a user-friendly fashion, each novel contribution being automatically compared to the reference baseline methods, which enables crowdsourced benchmarking. DECONbench is designed to serve as a reference platform for the benchmarking of deconvolution methods in the evaluation of cancer heterogeneity. We believe it will contribute to leverage the benchmarking practices in the biomedical and life science communities. DECONbench is hosted on the open source Codalab competition platform. It is freely available at: https://competitions.codalab.org/competitions/27453. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Tuberculosis and the under reporting of cases that evolved to death: Integrative Literature Review

Author

Martins, Ana Caroline Guedes Souza, primary, Ribeiro, Elidiane de Carvalho, additional, Oliveira, Jackline Leite de, additional, Sampaio, Antônia Roberta Mitre, additional, Balieiro, Rodrigo Batista, additional, Oliveira, Marcela Feitosa de, additional, Lima, Jhon Elis Cruz de, additional, Batista, Luciana Moreira, additional, Dias, Wesley Brandão, additional, Cardoso, Denise de Fátima Ferreira, additional, Bezerra, Ana Luisa Lemos, additional, Soares, Monike Karina Macedo, additional, Pinto, Izabela Moreira, additional, Silva, Eris Felipe Santos da, additional, Vale, Felipe Macedo, additional, Cagni, Hector Brenno da Silva, additional, Ribeiro, Larissa Maria Soares, additional, Pantoja, Alessandra Silva, additional, Lopes, Liandra Silva, additional, Paz, Márcia Geovanna Araújo, additional, Silva, Raisa Oksana Lídia Ellis Freire de Sena Garcia da, additional, Souza, Lauro Nascimento de, additional, Maués, Ana Júlia Góes, additional, Tavares, Iasmim Ianne Sousa, additional, Santos, Evelyn Rafaela de Almeida dos, additional, Silva, Rosália Cardoso da, additional, Farias, Ely dos Santos, additional, Lemos, Alda Lima, additional, Martins, Thamyres da Silva, additional, Reis, Daniele Lima dos Anjos, additional, Cunha, Taynnara de Oliveira do Espírito Santo, additional, Bezerra, Juliana de Oliveira, additional, Borges, Renata Campos de Sousa, additional, Caldato, Milena Coelho Fernandes, additional, Freire, Larissa Lima Figueira, additional, Baia, Lidiane de Nazaré Noronha Ferreira, additional, Rocha, Sabrina Macambira Guerra da, additional, Vasconcelos, Alex de Oliveira, additional, Barrêto, Alana de Oliveira, additional, Sá, Tayana Patrícia Santana Oliveira de, additional, Silva, Jordânia Guimarães, additional, Tavares, Tereza Cristina Abreu, additional, Santos, Simone Melo dos, additional, Silva, Luceme Martins, additional, Silva, Adriane Maria Bezerra da, additional, Neves, Thalyta Mayssa Paiva das, additional, Aviz, Paula Carolina Lima de, additional, Paes, Luciene dos Santos, additional, Mendes, Emanuelle Silva, additional, Barros, Kely da Silva, additional, Lago, Pamela Nery do, additional, Santos, Anderson Lineu Siqueira dos, additional, and Oliveira, Tatyellen Natasha da Costa, additional

Published
2020
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44. Influence of knowledge for organ and tissue donation for transplantation

Author

Carvalho, Felipe Aleixo de, primary, Costa, Leane dos Reis, additional, Antunes, Suane Priscila dos Santos, additional, Moraes, Clédia Maria Gomes, additional, Bender, Hermana Rayanne Lucas de Andrade, additional, Andrade, Darllene Lucas de, additional, Silva, Mayco Tadeu Vaz, additional, Sardinha, Rosenildo Maués, additional, Fernandes, Bruna Larissa Coelho, additional, Ribeiro, Letícia Lôide Pereira, additional, Cruz, Márcia Soraya Quaresma Vera, additional, Cerqueira, Liliane Souza Soares, additional, Lago, Pamela Nery do, additional, Reis, Luciene Maria dos, additional, Cardoso, Gabriela Cristina Vieira, additional, Santos, Maria Lúcia Costa dos, additional, Oliveira Junior, Eimar Neri de, additional, Lins, Marcio Almeida, additional, Lima, Paula Abitbol, additional, Soares, Rosinete Conceição Souza, additional, Santo, Leliane do Nascimento do Espírito, additional, Silva, Tatiane Peniche da, additional, Sousa, Giovanna Farias de, additional, Medeiros, Lauany Silva de, additional, Silva, Lorena Silva da, additional, Figueiredo Júnior, Adilson Mendes de, additional, Cardoso, Denise de Fátima Ferreira, additional, Silva, Adams Brunno, additional, Girard, Gleyce Pinto, additional, Maciel, Danielle Oliveira, additional, Borges, Renata Campos de Sousa, additional, Santos, Nilza Souza dos, additional, Mendonça, Elizangela Fonseca de, additional, Fortes, Flaviane dos Reis, additional, Brigida, Glaucilene Viana Santa, additional, Batista, Natália Ribeiro, additional, Sousa, Thais Santos de, additional, Batista, Luciana Moreira, additional, Carvalho, Alda Helena dos Santos, additional, Conceição, Dayhane Souza da, additional, Vera, Samuel Oliveira da, additional, Correia, Luziana Barros, additional, Ferreira, Gabriella Rodrigues, additional, Santos, Karine Honorato dos, additional, Silva, Rafaella, additional, Santos, Sávio Felipe Dias, additional, Nogueira, Maicon de Araujo, additional, and Sá, Antonia Margareth Moita, additional

Published
2020
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45. Nursing teaching in emergency care in a mass event: Experience report

Author

Borges, Renata Campos de Sousa, primary, Silva, Pollyane Aparecida Ferreira da, additional, Batista, Luciana Moreira, additional, Girard, Gleyce Pinto, additional, Lago, Pamela Nery do, additional, Marcena, Jaqueline Cardoso, additional, Vera, Samuel Oliveira da, additional, Maciel, Danielle Oliveira, additional, Lins, Marcio Almeida, additional, Netto, Lourival Freitas da Silva, additional, Favacho, Vanessa de Nazaré Mendes, additional, Almeida, Lucilena Estumano, additional, Oliveira Junior, Eimar Neri de, additional, Camacho, Elyade Nelly Pires Rocha, additional, Gonçalves, Danielle Rêgo, additional, Silva, Isabelle Dias da, additional, Souza, Larissa Carolina Dias de, additional, Carvalho, Izabel Silva, additional, Camacho, Fabio Feitosa, additional, Marinho, Thamyris Abreu, additional, Figueira, Simone Aguiar da Silva, additional, Nogueira, Maicon de Araujo, additional, Antunes, Suane Priscila dos Santos, additional, Fróes, Vinícius da Rocha, additional, Figueiredo Júnior, Adilson Mendes de, additional, Medeiros, Lauany Silva de, additional, Neves, Karolinne do Socorro Sousa, additional, Jesus, Haroldo Gonçalves de, additional, Cardoso, Heide da Silva, additional, Santos, Tailine da Silva, additional, Batista, Natália Ribeiro, additional, Nazaré, Gabrielle Reis de, additional, Sousa, Lucilene Lima, additional, Silva, Bruna Carolina da Trindade Monteiro da, additional, Caldas, Ana Carolina Lisboa, additional, Pinheiro, Mauro Sávio Sarmento, additional, Reis, Luciene Maria dos, additional, Silva, Denise Karla de Abreu, additional, Silva, Marlene Simões e, additional, Beata, Paulo Alaércio, additional, Freitas, Jofre Jacob da Silva, additional, Caldato, Milena Coelho Fernandes, additional, and Sá, Antonia Margareth Moita, additional

Published
2020
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48. Abstract 5529: PD-L1 and CD8 IHC dual assessment in NSCLC using the Halioseek® assay: A multicentric study

Author

Batista, Luciana, primary, Brandone, Nicolas, additional, Garcia, Stéphane, additional, Boumber, Yanis, additional, Dulaimi, Essel, additional, Tanière, Philippe, additional, Hofman, Paul, additional, Ilié, Marius, additional, Adam, Julien, additional, Galon, Jérôme, additional, Gerbon, Catherine, additional, and Fieschi, Jacques, additional

Published
2018
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50. Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through

Author

Batista, Luciana, Bourachot, Brigitte, Mateescu, Bogdan, Reyal, Fabien, Mechta-Grigoriou, Fatima, Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de recherche translationnelle, Institut Curie [Paris], L.B. was supported by fundings from the Ecole Polytechnique and the Institut Curie. The experimental work was also supported by grants from the Institut National de la Sante´ et de la Recherche Me´dicale (Inserm) and the Institut Curie. We also thank the Institut National du Cancer (INCa), the FRM and the Fondation ARC. Laboratory of F.M.-G. is labellized by the Ligue Nationale Contre le Cancer (LNCC). We are very grateful to the LNCC for providing support these last years., Mechta-Grigoriou, Fatima, and Département de Recherche Translationnelle

Subjects
Epigenomics, Ovarian Neoplasms, Transcription, Genetic, Science, [SDV]Life Sciences [q-bio], Protein Tyrosine Phosphatase, Non-Receptor Type 6, [SDV.CAN]Life Sciences [q-bio]/Cancer, Article, Cell Line, [SDV] Life Sciences [q-bio], Mice, MicroRNAs, [SDV.CAN] Life Sciences [q-bio]/Cancer, Gene Expression Regulation, Animals, Humans, DNA, Intergenic, Female, Signal Transduction
Abstract

The miR-200 family members have been implicated in stress responses and ovarian tumorigenesis. Here, we find that miR-200c/141 transcription is intimately linked to the transcription of the proximal upstream gene PTPN6 (SHP1) in all physiological conditions tested. PTPN6 and miR-200c/141 are transcriptionally co-regulated by two complementary mechanisms. First, a bypass of the regular PTPN6 polyadenylation signal allows the transcription of the downstream miR-200c/141. Second, the promoters of the PTPN6 and miR-200c/141 transcription units physically interact through a 3-dimensional DNA loop and exhibit similar epigenetic regulation. Our findings highlight that transcription of intergenic miRNAs is a novel outcome of transcriptional read-through and reveal a yet unexplored type of DNA loop associating two closely located promoters. These mechanisms have significant relevance in ovarian cancers and stress response, pathophysiological conditions in which miR-200c/141 exert key functions., The miR-141/200 familly of micro RNAs control oxidative stress and impact on ovarian tumorigenesis. Here the authors show that the transcription of miR-200c/141 is regulated through transcriptional read-through of the upstream gene PTPN6, and DNA looping linking the PTPN6 and miR-200c/141 promoters.

Published
2014
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