17 results on '"Battistutta, D."'
Search Results
2. 485 Symptom prevalence and temporal clustering of symptoms in people living with chronic hepatitis C infection
- Author
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Lang, C.A., Battistutta, D., Garrett, L.E., Cooksley, W.G.E., Dunne, M.P., and Macdonald, G.A.
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- 2004
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3. Evaluation of an intervention to promote protective infant feeding practices to prevent childhood obesity: outcomes of the NOURISH RCT at 14 months of age and 6 months post the first of two intervention modules.
- Author
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Daniels, L A, Mallan, K M, Battistutta, D, Nicholson, J M, Perry, R, and Magarey, A
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PUBLIC health , *PREVENTION of childhood obesity , *HEALTH outcome assessment , *RANDOMIZED controlled trials , *BREASTFEEDING , *WEIGHT gain in pregnancy - Abstract
Objective:To evaluate a universal obesity prevention intervention, which commenced at infant age 4-6 months, using outcome data assessed 6 months after completion of the first of two intervention modules and 9 months from baseline.Design:Randomised controlled trial of a community-based early feeding intervention.Subjects and methods:Six hundred and ninety-eight first-time mothers (mean age 30±5 years) with healthy term infants (51% male) aged 4.3±1.0 months at baseline. Mothers and infants were randomly allocated to self-directed access to usual care or to attend two group education modules, each delivered over 3 months, that provided anticipatory guidance on early feeding practices. Outcome data reported here were assessed at infant age 13.7±1.3 months. Anthropometrics were expressed as z-scores (WHO reference). Rapid weight gain was defined as change in weight-for-age z-score (WAZ) of >+0.67. Maternal feeding practices were assessed via self-administered questionnaire.Results:There were no differences according to group allocation on key maternal and infant characteristics. At follow-up (n=598 (86%)), the control group infants had higher BMI-for-age z-score (BMIZ) (0.42±0.85 vs 0.23±0.93, P=0.009) and were more likely to show rapid weight gain from baseline to follow-up (odds ratio (OR)=1.5, confidence interval (CI) 95%=1.1-2.1, P=0.014). Mothers in the control group were more likely to report using non-responsive feeding practices that fail to respond to infant satiety cues such as encouraging eating by using food as a reward (15% vs 4%, P=0.001) or using games (67% vs 29%, P<0.001).Conclusions:These results provide early evidence that anticipatory guidance targeting the 'when, what and how' of solid feeding can be effective in changing maternal feeding practices and, at least in the short term, reducing anthropometric indicators of childhood obesity risk. Analyses of outcomes at later ages are required to determine if these promising effects can be sustained. [ABSTRACT FROM AUTHOR]
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- 2012
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4. Identification of cancer-related symptom clusters: an empirical comparison of exploratory factor analysis methods.
- Author
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Skerman HM, Yates PM, and Battistutta D
- Abstract
CONTEXT: Symptom clusters, important for symptom management strategies, have been determined empirically by various analytical methods. Guidance to select methods from the options available in standard statistical packages is limited. OBJECTIVES: To compare alternative common factor analysis (FA) extraction methods appropriate to the data, to assess whether or not they determine similar symptom clusters, and to propose analytical approaches that are useful in this clinical context. METHODS: Within one month of commencing chemotherapy, outpatients from oncology and hematology clinics (n = 202) reported their symptom experience on a modified Rotterdam Symptom Checklist. Symptom distress levels in the past week were rated on a scale of one (not at all) to four (very much). In a secondary data analysis of 42 symptoms, the associations between symptoms and factors were determined using alternative common FA methods: principal axis factoring, unweighted least squares, image factor analysis, and alpha factor analysis (AFA). Symptom inclusion in a cluster was based on the interpretation of pattern and structure coefficients, and importantly, clinical relevance of the grouping. RESULTS: Five symptom clusters were commonly identified across methods: musculoskeletal discomforts/lethargy, oral discomforts, upper gastrointestinal discomforts, vasomotor symptoms, and gastrointestinal toxicities. In AFA, three additional clusters were lethargy, somatic symptoms, and treatment-related symptom clusters. CONCLUSION: The most parsimonious solution resulted from principal axis factoring, but for large numbers of symptoms, AFA may be superior by identifying symptom clusters more useful for symptom management. Interpreting complex symptom relationships may lead to the investigation of pathophysiological mechanisms and intervention opportunities. Future studies should include psychological and cognitive symptoms. [ABSTRACT FROM AUTHOR]
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- 2012
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5. Cancer-related symptom clusters for symptom management in outpatients after commencing adjuvant chemotherapy, at 6 months, and 12 months.
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Skerman HM, Yates PM, Battistutta D, Skerman, Helen M, Yates, Patsy M, and Battistutta, Diana
- Abstract
Goals Of Work: The aim of this secondary data analysis was to investigate symptom clusters over time for symptom management of a patient group after commencing adjuvant chemotherapy.Materials and Methods: A prospective longitudinal study of 219 cancer outpatients conducted within 1 month of commencing chemotherapy (T1), 6 months (T2), and 12 months (T3) later. Patients' distress levels were assessed for 42 physical symptoms on a clinician-modified Rotterdam Symptom Checklist. Symptom clusters were identified in exploratory factor analyses at each time. Symptom inclusion in clusters was determined from structure coefficients. Symptoms could be associated with multiple clusters. Stability over time was determined from symptom cluster composition and the proportion of symptoms in the initial symptom clusters replicated at later times.Main Results: Fatigue and daytime sleepiness were the most prevalent distressing symptoms over time. The median number of concurrent distressing symptoms approximated 7, over time. Five consistent clusters were identified at T1, T2, and T3. An additional two clusters were identified at 12 months, possibly due to less variation in distress levels. Weakness and fatigue were each associated with two, four, and five symptom clusters at T1, T2, and T3, respectively, potentially suggesting different causal mechanisms.Conclusion: Stability is a necessary attribute of symptom clusters, but definitional clarification is required. We propose that a core set of concurrent symptoms identifies each symptom cluster, signifying a common cause. Additional related symptoms may be included over time. Further longitudinal investigation is required to identify symptom clusters and the underlying causes. [ABSTRACT FROM AUTHOR]- Published
- 2012
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6. Case-Control Study of Early Childhood Caries in Australia.
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Seow, W. K., Clifford, H., Battistutta, D., Morawska, A., and Holcombe, T.
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JUVENILE diseases , *PEDIATRICS , *DENTAL caries , *DENTAL pathology - Abstract
The aim of this case-control study of 617 children was to investigate early childhood caries (ECC) risk indicators in a non-fluoridated region in Australia. ECC cases were recruited from childcare facilities, public hospitals and private specialist clinics to source children from different socioeconomic backgrounds. Non-ECC controls were recruited from the same childcare facilities. A multinomial logistic modelling approach was used for statistical analysis. The results showed that a large percentage of children tested positive for Streptococcus mutans if their mothers also tested positive. A common risk indicator found in ECC children from childcare facilities and public hospitals was visible plaque (OR 4.1, 95% CI 1.0–15.9, and OR 8.7, 95% CI 2.3–32.9, respectively). Compared to ECC-free controls, the risk indicators specific to childcare cases were enamel hypoplasia (OR 4.2, 95% CI 1.0–18.3), difficulty in cleaning child’s teeth (OR 6.6, 95% CI 2.2–19.8), presence of S. mutans (OR 4.8, 95% CI 0.7–32.6), sweetened drinks (OR 4.0, 95% CI 1.2–13.6) and maternal anxiety (OR 5.1, 95% CI 1.1–25.0). Risk indicators specific to public hospital cases were S. mutans presence in child (OR 7.7, 95% CI 1.3–44.6) or mother (OR 8.1, 95% CI 0.9–72.4), ethnicity (OR 5.6, 95% CI 1.4–22.1), and access of mother to pension or health care card (OR 20.5, 95% CI 3.5–119.9). By contrast, a history of chronic ear infections was found to be protective for ECC in childcare children (OR 0.28, 95% CI 0.09–0.82). The biological, socioeconomic and maternal risk indicators demonstrated in the present study can be employed in models of ECC that can be usefully applied for future longitudinal studies. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2009
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7. Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas.
- Author
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MacLennan R, Macrae F, Bain C, Battistutta D, Chapuis P, Gratten H, Lambert J, Newland RC, Ngu M, Russell A, Ward M, Wahlqvist ML, Australian Polyp Prevention Project, MacLennan, R, Macrae, F, Bain, C, Battistutta, D, Chapuis, P, Gratten, H, and Lambert, J
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Background: Epidemiologic evidence of associations between the high intake of fat and low intake of dietary fiber, beta carotene, and other dietary constituents and the risk of colorectal neoplasia has been inconsistent and has not provided a sufficient basis for recommendations concerning the dietary prevention of large-bowel cancer in humans.Purpose: We conducted a clinical trial to assess the effects on the incidence of adenomas of reducing dietary fat to 25% of total calories and supplementing the diet with 25 g of wheat bran daily and a capsule of beta carotene (20 mg daily).Methods: We performed a randomized, partially double-blinded, placebo-controlled factorial trial in which half the patients were assigned to each intervention, resulting in seven intervention groups and one control group. Eligibility criteria included histologic confirmation of at least one colorectal adenoma and confidence expressed by the colonoscopist that all polyps had been removed. Dietary changes were individually initiated and monitored by dietitians and research nurses. At surveillance colonoscopy, the size and location of all polyps were recorded, and their histology was later centrally reviewed. Among 424 patients who were randomly assigned in the trial, 13 were found to be ineligible upon histologic review. Among the remaining 411, complete outcome data were collected from 390 at 24 months and from 306 at 48 months. All P values are from two-sided tests of statistical significance.Results: There was no statistically significant prevention of total new adenomas with any of the interventions. We found a statistically non-significant reduced risk of large adenomas (> or = 10 mm) with the low-fat intervention: At 24 months, the odds ratio (OR) adjusted for potential confounders = 0.4 and 95% confidence interval (CI) = 0.1-1.1; at 48 months, OR = 0.3 and 95% CI = 0.1-1.0. Less and statistically nonsignificant reductions in the risk of large adenomas were found with wheat bran: At 24 months, OR = 0.8 and 95% CI = 0.3-2.2; at 48 months, OR = 0.8 and 95% CI = 0.3-2.5. Patients on the combined intervention of low fat and added wheat bran had zero large adenomas at both 24 and 48 months, a statistically significant finding (P = .03).Conclusions: Because only small numbers of patients were studied, our finding that the combination of fat reduction and a supplement of wheat bran reduced the incidence of large adenomas in this randomized, controlled trial must be treated with caution. The results do suggest, however, that these interventions may reduce the transition from smaller to larger adenomas, a step that may critically define those adenomas most likely to progress to malignancy. [ABSTRACT FROM AUTHOR]- Published
- 1995
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8. Upper-body morbidity following breast cancer treatment is common, may persist longer-term and adversely influences quality of life.
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Hayes SC, Rye S, Battistutta D, Disipio T, Newman B, Hayes, Sandra C, Rye, Sheree, Battistutta, Diana, DiSipio, Tracey, and Newman, Beth
- Abstract
Background: Impairments in upper-body function (UBF) are common following breast cancer. However, the relationship between arm morbidity and quality of life (QoL) remains unclear. This investigation uses longitudinal data to describe UBF in a population-based sample of women with breast cancer and examines its relationship with QoL.Methods: Australian women (n=287) with unilateral breast cancer were assessed at three-monthly intervals, from six- to 18-months post-surgery (PS). Strength, endurance and flexibility were used to assess objective UBF, while the Disability of the Arm, Shoulder and Hand questionnaire and the Functional Assessment of Cancer Therapy-Breast questionnaire were used to assess self-reported UBF and QoL, respectively.Results: Although mean UBF improved over time, up to 41% of women revealed declines in UBF between six- and 18-months PS. Older age, lower socioeconomic position, treatment on the dominant side, mastectomy, more extensive lymph node removal and having lymphoedema each increased odds of declines in UBF by at least two-fold (p<0.05). Lower baseline and declines in perceived UBF between six- and 18-months PS were each associated with poorer QoL at 18-months PS (p<0.05).Conclusions: Significant upper-body morbidity is experienced by many following breast cancer treatment, persisting longer term, and adversely influencing the QoL of breast cancer survivors. [ABSTRACT FROM AUTHOR]- Published
- 2010
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9. The NOURISH randomised control trial: positive feeding practices and food preferences in early childhood - a primary prevention program for childhood obesity.
- Author
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Daniels LA, Magarey A, Battistutta D, Nicholson JM, Farrell A, Davidson G, Cleghorn G, Daniels, Lynne A, Magarey, Anthea, Battistutta, Diana, Nicholson, Jan M, Farrell, Ann, Davidson, Geoffrey, and Cleghorn, Geoffrey
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PREVENTION of childhood obesity , *DIABETES , *STATISTICAL sampling , *SOCIAL support , *RANDOMIZED controlled trials , *TREATMENT effectiveness - Abstract
Background: Primary prevention of childhood overweight is an international priority. In Australia 20-25% of 2-8 year olds are already overweight. These children are at substantially increased the risk of becoming overweight adults, with attendant increased risk of morbidity and mortality. Early feeding practices determine infant exposure to food (type, amount, frequency) and include responses (eg coercion) to infant feeding behaviour (eg. food refusal). There is correlational evidence linking parenting style and early feeding practices to child eating behaviour and weight status. A focus on early feeding is consistent with the national focus on early childhood as the foundation for life-long health and well being. The NOURISH trial aims to implement and evaluate a community-based intervention to promote early feeding practices that will foster healthy food preferences and intake and preserve the innate capacity to self-regulate food intake in young children.Methods/design: This randomised controlled trial (RCT) aims to recruit 820 first-time mothers and their healthy term infants. A consecutive sample of eligible mothers will be approached postnatally at major maternity hospitals in Brisbane and Adelaide. Initial consent will be for re-contact for full enrolment when the infants are 4-7 months old. Individual mother- infant dyads will be randomised to usual care or the intervention. The intervention will provide anticipatory guidance via two modules of six fortnightly parent education and peer support group sessions, each followed by six months of regular maintenance contact. The modules will commence when the infants are aged 4-7 and 13-16 months to coincide with establishment of solid feeding, and autonomy and independence, respectively. Outcome measures will be assessed at baseline, with follow up at nine and 18 months. These will include infant intake (type and amount of foods), food preferences, feeding behaviour and growth and self-reported maternal feeding practices and parenting practices and efficacy. Covariates will include sociodemographics, infant feeding mode and temperament, maternal weight status and weight concern and child care exposure.Discussion: Despite the strong rationale to focus on parents' early feeding practices as a key determinant of child food preferences, intake and self-regulatory capacity, prospective longitudinal and intervention studies are rare. This trial will be amongst to provide Level II evidence regarding the impact of an intervention (commencing prior to age 12 months) on children's eating patterns and behaviours.Trial Registration: ACTRN12608000056392. [ABSTRACT FROM AUTHOR]- Published
- 2009
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10. A path analysis modeling the symptom experience of cancer patients commencing adjuvant treatment in ambulatory clinics.
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Skerman H, Yates P, and Battistutta D
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- 2007
11. Clinical accuracy of the MedGem indirect calorimeter for measuring resting energy expenditure in cancer patients.
- Author
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Reeves, M M, Capra, S, Bauer, J, Davies, P S W, and Battistutta, D
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- 2005
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12. Clinical accuracy of the MedGem™indirect calorimeter for measuring resting energy expenditure in cancer patients.
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Reeves, M. M., Capra, S., Bauer, J., Davies, P. S. W., and Battistutta, D.
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CANCER , *CANCER patients , *CALORIMETERS , *TEMPERATURE measuring instruments - Abstract
OBJECTIVE:: To compare, in patients with cancer and in healthy subjects, measured resting energy expenditure (REE) from traditional indirect calorimetry to a new portable device (MedGem™) and predicted REE. DESIGN:: Cross-sectional clinical validation study. SETTING:: Private radiation oncology centre, Brisbane, Australia. SUBJECTS:: Cancer patients (n=18) and healthy subjects (n=17) aged 37-86?y, with body mass indices ranging from 18 to 42?kg/m2. INTERVENTIONS:: Oxygen consumption (VO2) and REE were measured by VMax229 (VM) and MedGem (MG) indirect calorimeters in random order after a 12-h fast and 30-min rest. REE was also calculated from the MG without adjustment for nitrogen excretion (MGN) and estimated from Harris-Benedict prediction equations. Data were analysed using the Bland and Altman approach, based on a clinically acceptable difference between methods of 5%. RESULTS:: The mean bias (MGN-VM) was 10%and limits of agreement were-42 to 21%for cancer patients; mean bias-5%with limits of-45 to 35%for healthy subjects. Less than half of the cancer patients (n=7, 46.7%) and only a third (n=5, 33.3%) of healthy subjects had measured REE by MGN within clinically acceptable limits of VM. Predicted REE showed a mean bias (HB-VM) of-5%for cancer patients and 4%for healthy subjects, with limits of agreement of-30 to 20%and-27 to 34%, respectively. CONCLUSIONS:: Limits of agreement for the MG and Harris Benedict equations compared to traditional indirect calorimetry were similar but wide, indicating poor clinical accuracy for determining the REE of individual cancer patients and healthy subjects.European Journal of Clinical Nutrition (2005) 59, 603-610. doi:10.1038/sj.ejcn.1602114 Published online 2 March 2005 [ABSTRACT FROM AUTHOR]
- Published
- 2005
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13. Greene Climacteric Scale: norms in an Australian population in relation to age and menopausal status.
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Travers, C., O'Neill, S. M., King, R., Battistutta, D., and Khoo, S. K.
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MENOPAUSE , *CLIMACTERIC , *HORMONE therapy , *MEDICAL personnel , *VASOMOTOR system , *MENTAL depression - Abstract
Objectives The aim of this study was two-fold: to assess climacteric symptoms and provide normative data for the Greene Climacteric Scale during the menopause transition, and to investigate the prevalence of climacteric symptoms in a representative sample of postmenopausal Australian women. Method A cohort of 500 premenopausal, perimenopausal and postmenopausal women aged 40–80 years participated in the Longitudinal Study of Ageing in Women (LAW study) at the Royal Brisbane and Women's Hospital, Brisbane, Australia. In year 1 of the study (2001), all participants completed the Greene Climacteric Scale and information regarding their menopausal status and the use of hormone therapy (HT) was obtained through a clinical interview with a qualified medical practitioner. Results The 50–59-year age group achieved the highest scores on the vasomotor and the depression scales in comparison to other age groups. Significant differences were also evident on the vasomotor and the depression scales on the basis of menopausal status, especially in perimenopausal women. Approximately 10% of women in the 60–79-year age group continued to experience vasomotor symptoms. Conclusion Vasomotor symptoms, as assessed by the Greene Climacteric Scale, are common during the menopause transition and remain elevated for some years in a minority of older postmenopausal women. The norms presented in this study are appropriate for use in an Australian population. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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14. EFFECTS OF A PROGRAM OF INTERVENTION ON PARENTAL DISTRESS FOLLOWING INFANT DEATH.
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Murray, Judith A., Terry, Deborah J., Vance, John C., Battistutta, D., and Connolly, Y.
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PSYCHOLOGICAL distress , *PSYCHOLOGY of parents , *INFANT death - Abstract
A longitudinal study of 144 parents (65 fathers, 79 mothers) was conducted to evaluate the effectiveness of a program of intervention in relieving the psychological distress of parents a ected by infant death. Participants were assessed in terms of their psychiatric disturbance, depression, anxiety, physical symptoms, dyadic adjustment, and coping strategies. The experimental group (n=84) was offered an intervention program comprising the use of specially designed resources and contact with a trained grief worker. A control group (n=60) was given routine community care. Parental reactions were assessed at four to six weeks postloss (prior to the implementation of the intervention program), at six months postloss, and at 15 months postloss. A series of multivariate analyses of variance revealed that the intervention was effective in reducing the distress of parents, particularly those assessed prior to the intervention as being at high-risk of developing mourning difficulties. Effects of the intervention were noted in terms of parents overall psychiatric disturbance, marital quality, and paternal coping strategies. [ABSTRACT FROM AUTHOR]
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- 2000
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15. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial.
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Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, Marks GC, Gaffney P, Battistutta D, Frost C, Lang C, and Russell A
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- 1999
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16. Predictors of bereavement outcome for family carers of cancer patients.
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Kelly B, Edwards P, Synott R, Neil C, Baillie R, and Battistutta D
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- 1999
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17. Predictors of bereavement outcome for family carers of cancer patients.
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Kelly, B., Edwards, P., Synott, R., Neil, C., Baillie, R., and Battistutta, D.
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CAREGIVERS , *BEREAVEMENT , *CANCER patients , *OPERANT behavior , *PALLIATIVE treatment , *PSYCHOMETRICS , *COMMUNITY health services - Abstract
Aims: The psychological outcome of family carers after bereavement is an important issue in evaluating palliative care services. Palliative care services have the potential to provide preventive psychosocial intervention to family carers prior to bereavement, but are faced with the need to identify those who may have greatest risk of adverse outcome. This prospective study examines predictors of psychological outcome for family carers of cancer patients following bereavement based on factors identified at referral to a palliative care agency. Methods: Cancer patients and their family carer were consecutively recruited and assessed on a range of clinical and psychological measures at referral to a palliative home care service in a metropolitan centre (Time 1). Carers were again assessed following the death of the patient, on average at 4 months post-bereavement (Time 2), using measures of bereavement symptoms and psychological morbidity. Results: 178 carers were assessed on both occasions. The chief predictors of carer psychological symptoms and severity of grief at follow-up were psychological symptom scores at the time of referral (Time 1). Factors also measured at Time 1 were significant predictors of symptoms and grief scores at Time 2: greater number of adverse life events, carer's coping responses, past bereavement and separation experiences, the relationship with the patient, and greater severity of patient's illness at the time of palliative care referral. Conclusions: The findings indicate clinical risk factors for adverse short-term bereavement outcome that can be identified in family carers during palliative care treatment, that have implications for identifying the psychological needs of carers, and that form a potential basis for interventions to enhance the psychological outcome for family carers. Copyright © 1999 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 1999
- Full Text
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