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2. Early Onset Intrahepatic Cholangiocarcinoma: Clinical Characteristics, Oncological Outcomes, and Genomic/Transcriptomic Features

Author

Tsilimigras, Diamantis I., Han, Xu, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Chaucy, François, Koerkamp, Bas Groot, Endo, Itaru, Sasaki, Kazunari, Aucejo, Federico, Zhang, Xu-Feng, Zhu, Hua, and Pawlik, Timothy M.

Published
2024
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3. Benchmarks in Liver Resection for Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, Endo, Yutaka, Catalano, Giovanni, Ruzzenente, Andrea, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, Kitago, Minoru, and Pawlik, Timothy M.

Published
2024
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7. Development and Validation of a Machine-Learning Model to Predict Early Recurrence of Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, Lima, Henrique A., Moazzam, Zorays, Endo, Yutaka, Yang, Jason, Ruzzenente, Andrea, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, Kitago, Minoru, and Pawlik, Timothy M.

Published
2023
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8. The complication-overall survival (CompOS) risk tool predicts risk of a severe postoperative complications relative to long-term survival among patients with primary liver cancer

Author

Endo, Yutaka, Tsilimigras, Diamantis I., Woldesenbet, Selamawit, Marques, Hugo P., Cauchy, François, Weiss, Matthew, Bauer, Todd W., Poultsides, George A., Maithel, Shishir K., Kitago, Minoru, Alexandrescu, Sorin, Martel, Guillaume, Guglielmi, Alfredo, Pulitano, Carlo, Gleisner, Ana, Hugh, Tom, Aldrighetti, Luca, Shen, Feng, Koerkamp, Bas G., Endo, Itaru, and Pawlik, Timothy M.

Published
2024
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9. Predictors and Prognostic Significance of Postoperative Complications for Patients with Intrahepatic Cholangiocarcinoma

Author

Endo, Yutaka, Moazzam, Zorays, Woldesenbet, Selamawit, Araujo Lima, Henrique, Alaimo, Laura, Munir, Muhammad Musaab, Shaikh, Chanza F., Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Kitago, Minoru, Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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10. Higher Tumor Burden Status Dictates the Impact of Surgical Margin Status on Overall Survival in Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma

Author

Endo, Yutaka, Sasaki, Kazunari, Moazzam, Zorays, Lima, Henrique A., Alaimo, Laura, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Kitago, Minoru, Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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11. The Application of Artificial Intelligence to Investigate Long-Term Outcomes and Assess Optimal Margin Width in Hepatectomy for Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, Moazzam, Zorays, Endo, Yutaka, Lima, Henrique A., Butey, Swatika P., Ruzzenente, Andrea, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, Kitago, Minoru, Kim, Alex, Ejaz, Aslam, Beane, Joal, Cloyd, Jordan, and Pawlik, Timothy M.

Published
2023
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12. Albumin-Bilirubin Grade and Tumor Burden Score Predict Outcomes Among Patients with Intrahepatic Cholangiocarcinoma After Hepatic Resection: a Multi-Institutional Analysis

Author

Munir, Muhammad Musaab, Endo, Yutaka, Lima, Henrique A., Alaimo, Laura, Moazzam, Zorays, Shaikh, Chanza, Poultsides, George A., Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Kitago, Minoru, Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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13. Lymph Node Examination and Patterns of Nodal Metastasis Among Patients with Left- Versus Right-Sided Intrahepatic Cholangiocarcinoma After Major Curative-Intent Resection

Author

Zhang, Xu-Feng, Xue, Feng, Weiss, Matthew, Popescu, Irinel, Marques, Hugo P., Aldrighetti, Luca, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Cauchy, François, Martel, Guillaume, Koerkamp, B. Groot, Itaru, Endo, Lv, Yi, and Pawlik, Timothy M.

Published
2023
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14. Long-Term Recurrence-Free and Overall Survival Differ Based on Common, Proliferative, and Inflammatory Subtypes After Resection of Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, Moazzam, Zorays, Endo, Yutaka, Lima, Henrique A., Ruzzenente, Andrea, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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15. Application of Hazard Function to Investigate Recurrence of Intrahepatic Cholangiocarcinoma After Curative-Intent Liver Resection: A Novel Approach to Characterize Recurrence

Author

Alaimo, Laura, Moazzam, Zorays, Brown, Zachary J., Endo, Yutaka, Ruzzenente, Andrea, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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16. An attempt to establish and apply global benchmarks for liver resection of malignant hepatic tumors

Author

Alaimo, Laura, Moazzam, Zorays, Lima, Henrique A., Endo, Yutaka, Ruzzenente, Andrea, Guglielmi, Alfredo, Ratti, Francesca, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Popescu, Irinel, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, Kitago, Minoru, Aucejo, Federico, Sasaki, Kazunari, Fields, Ryan C., Hugh, Tom, Lam, Vincent, and Pawlik, Timothy M.

Published
2023
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18. Supplementary Figure S8 from A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer

Author

Brown, Brooke A., primary, Myers, Paul J., primary, Adair, Sara J., primary, Pitarresi, Jason R., primary, Sah-Teli, Shiv K., primary, Campbell, Logan A., primary, Hart, William S., primary, Barbeau, Michelle C., primary, Leong, Kelsey, primary, Seyler, Nicholas, primary, Kane, William, primary, Lee, Kyoung Eun, primary, Stelow, Edward, primary, Jones, Marieke, primary, Simon, M. Celeste, primary, Koivunen, Peppi, primary, Bauer, Todd W., primary, Stanger, Ben Z., primary, and Lazzara, Matthew J., primary

Published
2024
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19. Data from A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer

Author

Brown, Brooke A., primary, Myers, Paul J., primary, Adair, Sara J., primary, Pitarresi, Jason R., primary, Sah-Teli, Shiv K., primary, Campbell, Logan A., primary, Hart, William S., primary, Barbeau, Michelle C., primary, Leong, Kelsey, primary, Seyler, Nicholas, primary, Kane, William, primary, Lee, Kyoung Eun, primary, Stelow, Edward, primary, Jones, Marieke, primary, Simon, M. Celeste, primary, Koivunen, Peppi, primary, Bauer, Todd W., primary, Stanger, Ben Z., primary, and Lazzara, Matthew J., primary

Published
2024
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20. Supplementary Data from A Histone Methylation–MAPK Signaling Axis Drives Durable Epithelial–Mesenchymal Transition in Hypoxic Pancreatic Cancer

Author

Brown, Brooke A., primary, Myers, Paul J., primary, Adair, Sara J., primary, Pitarresi, Jason R., primary, Sah-Teli, Shiv K., primary, Campbell, Logan A., primary, Hart, William S., primary, Barbeau, Michelle C., primary, Leong, Kelsey, primary, Seyler, Nicholas, primary, Kane, William, primary, Lee, Kyoung Eun, primary, Stelow, Edward, primary, Jones, Marieke, primary, Simon, M. Celeste, primary, Koivunen, Peppi, primary, Bauer, Todd W., primary, Stanger, Ben Z., primary, and Lazzara, Matthew J., primary

Published
2024
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22. The impact of tumor location on the value of lymphadenectomy for intrahepatic cholangiocarcinoma

Author

Endo, Yutaka, Moazzam, Zorays, Lima, Henrique A., Alaimo, Laura, Munir, Muhammad M., Shaikh, Chanza F., Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Kitago, Minoru, Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas G., Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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23. ASO Visual Abstract: The Application of Artificial Intelligence to Investigate Long-Term Outcomes and Assess Optimal Margin Width in Hepatectomy for Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, Moazzam, Zorays, Endo, Yutaka, Lima, Henrique A., Butey, Swatika P., Ruzzenente, Andrea, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, Kitago, Minoru, Kim, Alex, Ejaz, Aslam, Beane, Joal, Cloyd, Jordan, and Pawlik, Timothy M.

Published
2023
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24. ASO Visual Abstract: Development and Validation of a Machine Learning Model to Predict Early Recurrence of Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, Lima, Henrique A., Moazzam, Zorays, Endo, Yutaka, Yang, Jason, Ruzzenente, Andrea, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, Kitago, Minoru, and Pawlik, Timothy M.

Published
2023
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25. Predictive risk-score model to select patients with intrahepatic cholangiocarcinoma for adjuvant chemotherapy

Author

Endo, Yutaka, Moazzam, Zorays, Alaimo, Laura, Lima, Henrique A., Munir, Muhammad M., Shaikh, Chanza F., Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Kitago, Minoru, Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas G., Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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28. Cancer-oocyte SAS1B protein is expressed at the cell surface of multiple solid tumors and targeted with antibody-drug conjugates

Author

Mandal, Arabinda, primary, Shetty, Jagathpala, additional, Tran, Christine A, additional, Olson, Walter C, additional, Mandal, Mriganka, additional, Ban, Bhupal, additional, Pires, Eusebio S, additional, Adair, Sara J, additional, Bauer, Todd W, additional, Slingluff, Craig L, additional, and Herr, John C, additional

Published
2024
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29. Supplementary Data 1 from PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer

Author

Ali, Lestat R., primary, Lenehan, Patrick J., primary, Cardot-Ruffino, Victoire, primary, Dias Costa, Andressa, primary, Katz, Matthew H.G., primary, Bauer, Todd W., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, Abrams, Thomas A., primary, Patel, Anuj, primary, Clancy, Thomas E., primary, Wang, Jiping, primary, Mancias, Joseph D., primary, Reilley, Matthew J., primary, Stucky, Chee-Chee H., primary, Bekaii-Saab, Tanios S., primary, Elias, Rawad, primary, Merchant, Nipun, primary, Slingluff, Craig L., primary, Rahma, Osama E., primary, and Dougan, Stephanie K., primary

Published
2024
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30. Arm B count matrices 4 from PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer

Author

Ali, Lestat R., primary, Lenehan, Patrick J., primary, Cardot-Ruffino, Victoire, primary, Dias Costa, Andressa, primary, Katz, Matthew H.G., primary, Bauer, Todd W., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, Abrams, Thomas A., primary, Patel, Anuj, primary, Clancy, Thomas E., primary, Wang, Jiping, primary, Mancias, Joseph D., primary, Reilley, Matthew J., primary, Stucky, Chee-Chee H., primary, Bekaii-Saab, Tanios S., primary, Elias, Rawad, primary, Merchant, Nipun, primary, Slingluff, Craig L., primary, Rahma, Osama E., primary, and Dougan, Stephanie K., primary

Published
2024
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31. Data from PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer

Author

Ali, Lestat R., primary, Lenehan, Patrick J., primary, Cardot-Ruffino, Victoire, primary, Dias Costa, Andressa, primary, Katz, Matthew H.G., primary, Bauer, Todd W., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, Abrams, Thomas A., primary, Patel, Anuj, primary, Clancy, Thomas E., primary, Wang, Jiping, primary, Mancias, Joseph D., primary, Reilley, Matthew J., primary, Stucky, Chee-Chee H., primary, Bekaii-Saab, Tanios S., primary, Elias, Rawad, primary, Merchant, Nipun, primary, Slingluff, Craig L., primary, Rahma, Osama E., primary, and Dougan, Stephanie K., primary

Published
2024
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32. Arm A count matrices 3 from PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer

Author

Ali, Lestat R., primary, Lenehan, Patrick J., primary, Cardot-Ruffino, Victoire, primary, Dias Costa, Andressa, primary, Katz, Matthew H.G., primary, Bauer, Todd W., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, Abrams, Thomas A., primary, Patel, Anuj, primary, Clancy, Thomas E., primary, Wang, Jiping, primary, Mancias, Joseph D., primary, Reilley, Matthew J., primary, Stucky, Chee-Chee H., primary, Bekaii-Saab, Tanios S., primary, Elias, Rawad, primary, Merchant, Nipun, primary, Slingluff, Craig L., primary, Rahma, Osama E., primary, and Dougan, Stephanie K., primary

Published
2024
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33. Table S1 from PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer

Author

Ali, Lestat R., primary, Lenehan, Patrick J., primary, Cardot-Ruffino, Victoire, primary, Dias Costa, Andressa, primary, Katz, Matthew H.G., primary, Bauer, Todd W., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, Abrams, Thomas A., primary, Patel, Anuj, primary, Clancy, Thomas E., primary, Wang, Jiping, primary, Mancias, Joseph D., primary, Reilley, Matthew J., primary, Stucky, Chee-Chee H., primary, Bekaii-Saab, Tanios S., primary, Elias, Rawad, primary, Merchant, Nipun, primary, Slingluff, Craig L., primary, Rahma, Osama E., primary, and Dougan, Stephanie K., primary

Published
2024
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34. TCR raw data 2 from PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-κB Signaling in Patients with Pancreatic Cancer

Author

Ali, Lestat R., primary, Lenehan, Patrick J., primary, Cardot-Ruffino, Victoire, primary, Dias Costa, Andressa, primary, Katz, Matthew H.G., primary, Bauer, Todd W., primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, Abrams, Thomas A., primary, Patel, Anuj, primary, Clancy, Thomas E., primary, Wang, Jiping, primary, Mancias, Joseph D., primary, Reilley, Matthew J., primary, Stucky, Chee-Chee H., primary, Bekaii-Saab, Tanios S., primary, Elias, Rawad, primary, Merchant, Nipun, primary, Slingluff, Craig L., primary, Rahma, Osama E., primary, and Dougan, Stephanie K., primary

Published
2024
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35. ASO Visual Abstract: Long-Term Recurrence-Free and Overall Survival Differ Based on Common, Proliferative, and Inflammatory Subtypes After Resection of Intrahepatic Cholangiocarcinoma

Author

Alaimo, Laura, Moazzam, Zorays, Endo, Yutaka, Lima, Henrique A., Ruzzenente, Andrea, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Cauchy, François, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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36. ASO Visual Abstract: Application of Hazard Function to Investigate Recurrence of Intrahepatic Cholangiocarcinoma After Curative-Intent Liver Resection: A Novel Approach to Characterize Recurrence

Author

Alaimo, Laura, Moazzam, Zorays, Brown, Zachary J., Endo, Yutaka, Ruzzenente, Andrea, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2023
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40. ASO Visual Abstract: Dynamic Prediction of Survival After Curative Resection of Intrahepatic Cholangiocarcinoma: A Landmarking-Based Analysis

Author

Spolverato, Gaya, Capelli, Giulia, Lorenzoni, Giulia, Gregori, Dario, He, Jin, Popescu, Irinel, Marques, Hugo P., Aldrighetti, Luca, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Soubrane, Oliver, Martel, Guillaume, Koerkamp, Bas Groot, Itaru, Endo, Lv, Yi, and Pawlik, Timothy M.

Published
2022
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41. Predicting risk of recurrence after resection of stage I intrahepatic cholangiocarcinoma

Author

Kawashima, Jun, primary, Sahara, Kota, additional, Shen, Feng, additional, Guglielmi, Alfredo, additional, Aldrighetti, Luca, additional, Weiss, Matthew, additional, Bauer, Todd W., additional, Alexandrescu, Sorin, additional, Poultsides, George A., additional, Maithel, Shishir K., additional, Marques, Hugo P., additional, Martel, Guillaume, additional, Pulitano, Carlo, additional, Cauchy, François, additional, Koerkamp, B. Groot, additional, Matsuyama, Ryusei, additional, Endo, Itaru, additional, and Pawlik, Timothy M., additional

Published
2024
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43. Predicting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma

Author

Tsilimigras, Diamantis I., Sahara, Kota, Paredes, Anghela Z., Moro, Amika, Mehta, Rittal, Moris, Dimitrios, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2021
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44. Tumor Burden Dictates Prognosis Among Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma: A Tool to Guide Post-Resection Adjuvant Chemotherapy?

Author

Tsilimigras, Diamantis I., Hyer, J. Madison, Paredes, Anghela Z., Moris, Dimitrios, Sahara, Kota, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Koerkamp, Bas Groot, Endo, Itaru, Sasaki, Kazunari, Aucejo, Federico, Zhang, Xu-Feng, and Pawlik, Timothy M.

Published
2021
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45. ASO Visual Abstract: Tumor Necrosis Impacts the Prognosis of Patients Undergoing Resection for T1 Intrahepatic Cholangiocarcinoma

Author

Tsilimigras, Diamantis I., Ejaz, Aslam, Cloyd, Jordan, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Groot Koerkamp, Bas, Endo, Itaru, and Pawlik, Timothy M.

Published
2022
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46. The systemic immune-inflammation index predicts prognosis in intrahepatic cholangiocarcinoma: an international multi-institutional analysis

Author

Tsilimigras, Diamantis I., Moris, Dimitrios, Mehta, Rittal, Paredes, Anghela Z., Sahara, Kota, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Koerkamp, Bas G., Endo, Itaru, and Pawlik, Timothy M.

Published
2020
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47. Dielectrophoretic enrichment of live chemo-resistant circulating-like pancreatic cancer cells from media of drug-treated adherent cultures of solid tumors.

Author

Rane, Aditya, Jarmoshti, Javad, Siddique, Abdullah-Bin, Adair, Sara, Torres-Castro, Karina, Honrado, Carlos, Bauer, Todd W., and Swami, Nathan S.

Subjects
CANCER cells, PANCREATIC cancer, CANCER cell culture, CELL size, EXTRACELLULAR matrix, SUPERVISED learning, PANCREATIC tumors
Abstract

Due to low numbers of circulating tumor cells (CTCs) in liquid biopsies, there is much interest in enrichment of alternative circulating-like mesenchymal cancer cell subpopulations from in vitro tumor cultures for utilization within molecular profiling and drug screening. Viable cancer cells that are released into the media of drug-treated adherent cancer cell cultures exhibit anoikis resistance or anchorage-independent survival away from their extracellular matrix with nutrient sources and waste sinks, which serves as a pre-requisite for metastasis. The enrichment of these cell subpopulations from tumor cultures can potentially serve as an in vitro source of circulating-like cancer cells with greater potential for scale-up in comparison with CTCs. However, these live circulating-like cancer cell subpopulations exhibit size overlaps with necrotic and apoptotic cells in the culture media, which makes it challenging to selectively enrich them, while maintaining them in their suspended state. We present optimization of a flowthrough high frequency (1 MHz) positive dielectrophoresis (pDEP) device with sequential 3D field non-uniformities that enables enrichment of the live chemo-resistant circulating cancer cell subpopulation from an in vitro culture of metastatic patient-derived pancreatic tumor cells. Central to this strategy is the utilization of single-cell impedance cytometry with gates set by supervised machine learning, to optimize the frequency for pDEP, so that live circulating cells are selected based on multiple biophysical metrics, including membrane physiology, cytoplasmic conductivity and cell size, which is not possible using deterministic lateral displacement that is solely based on cell size. Using typical drug-treated samples with low levels of live circulating cells (<3%), we present pDEP enrichment of the target subpopulation to ∼44% levels within 20 minutes, while rejecting >90% of dead cells. This strategy of utilizing single-cell impedance cytometry to guide the optimization of dielectrophoresis has implications for other complex biological samples. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Redefining Conditional Overall and Disease-Free Survival After Curative Resection for Intrahepatic Cholangiocarcinoma: a Multi-institutional, International Study of 1221 patients

Author

Hu, Liang-Shuo, Zhang, Xu-Feng, Weiss, Matthew, Popescu, Irinel, Marques, Hugo P., Aldrighetti, Luca, Maithel, Shishir K., Pulitano, Carlo, Bauer, Todd W., Shen, Feng, Poultsides, George A., Soubrane, Oliver, Martel, Guillaume, Koerkamp, B. Groot, Itaru, Endo, Lv, Yi, and Pawlik, Timothy M.

Published
2020
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49. A Novel Classification of Intrahepatic Cholangiocarcinoma Phenotypes Using Machine Learning Techniques: An International Multi-Institutional Analysis

Author

Tsilimigras, Diamantis I., Hyer, J. Madison, Paredes, Anghela Z., Diaz, Adrian, Moris, Dimitrios, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2020
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50. Development and Validation of a Laboratory Risk Score (LabScore) to Predict Outcomes after Resection for Intrahepatic Cholangiocarcinoma

Author

Paredes, Anghela Z., Moris, Dimitrios, Sahara, Kota, Bagante, Fabio, Guglielmi, Alfredo, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Marques, Hugo P., Pulitano, Carlo, Soubrane, Olivier, Cloyd, Jordan M., Ejaz, Aslam, Tsilimigras, Diamantis I., Mehta, Rittal, Aldrighetti, Luca, Poultsides, George A., Maithel, Shishir K., Martel, Guillaume, Shen, Feng, Koerkamp, Bas Groot, Endo, Itaru, and Pawlik, Timothy M.

Published
2020
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