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1,016 results on '"Baulieu, Etienne-Emile"'

2. A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo.

Author

Lesport, Emilie, Commeau, Lucie, Genet, Mélanie, Baulieu, Etienne-Emile, Tawk, Marcel, and Giustiniani, Julien

Subjects
AUTOPHAGY, AXONAL transport, TAUOPATHIES, MUTANT proteins, TAU proteins
Abstract

The failure of the autophagy-lysosomal pathway to clear the pathogenic forms of Tau exacerbates the pathogenesis of tauopathies. We have previously shown that the immunophilin FKBP52 interacts both physically and functionally with Tau, and that a decrease in FKBP52 protein levels is associated with Tau deposition in affected human brains. We have also shown that FKBP52 is physiologically present within the lysosomal system in healthy human neurons and that a decrease in FKBP52 expression alters perinuclear lysosomal positioning and Tau clearance during Tau-induced proteotoxic stress in vitro. In this study, we generate a zebrafish fkbp4 loss of function mutant and show that axonal retrograde trafficking of Lamp1 vesicles is altered in this mutant. Moreover, using our transgenic HuC::mCherry-EGFP-LC3 line, we demonstrate that the autophagic flux is impaired in fkbp4 mutant embryos, suggesting a role for Fkbp52 in the maturation of autophagic vesicles. Alterations in both axonal transport and autophagic flux are more evident in heterozygous rather than homozygous fkbp4 mutants. Finally, taking advantage of the previously described A152T-Tau transgenic fish, we show that the clearance of pathogenic A152T-Tau mutant proteins is slower in fkbp4+/- mutants in comparison to fkbp4+/+ larvae. Altogether, these results indicate that Fkbp52 is required for the normal trafficking and maturation of lysosomes and autophagic vacuoles along axons, and that its decrease is sufficient to hinder the clearance of pathogenic Tau in vivo. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis

Author

Shackleford, Ghjuvan’Ghjacumu, Sampathkumar, Nirmal Kumar, Hichor, Mehdi, Weill, Laure, Meffre, Delphine, Juricek, Ludmila, Laurendeau, Ingrid, Chevallier, Aline, Ortonne, Nicolas, Larousserie, Frédérique, Herbin, Marc, Bièche, Ivan, Coumoul, Xavier, Beraneck, Mathieu, Baulieu, Etienne-Emile, Charbonnier, Frédéric, Pasmant, Eric, and Massaad, Charbel

Published
2018

10. Role for Glyoxalase I in Alzheimer's Disease

Author

Chen, Feng, Wollmer, M. Axel, Hoerndli, Frederic, Münch, Gerald, Kuhla, Björn, Rogaev, Evgeny I., Tsolaki, Magdalini, Papassotiropoulos, Andreas, Götz, Jürgen, and Baulieu, Etienne-Emile

Published
2004

18. Dehydroepiandrosterone (DHEA), DHEA Sulfate, and Aging: Contribution of the DHEAge Study to a Sociobiomedical Issue

Author

Baulieu, Etienne-Emile, Thomas, Guy, Legrain, Sylvie, Lahlou, Najiba, Roger, Marc, Debuire, Brigitte, Faucounau, Veronique, Girard, Laurence, Hervy, Marie-Pierre, Latour, Florence, Leaud, Marie-Celine, Mokrane, Amina, Pitti-Ferrandi, Helene, Trivalle, Christophe, de Lacharriere, Olivier, Nouveau, Stephanie, Rakoto-Arison, Brigitte, Souberbielle, Jean-Claude, Raison, Jocelyne, Le Bouc, Yves, Raynaud, Agathe, Girerd, Xavier, and Forette, Francoise

Published
2000

43. Lithium enhances remyelination of peripheral nerves

Author

Makoukji, Joelle, Belle, Martin, Meffre, Delphine, Stassart, Ruth, Grenier, Julien, Shackleford, Ghjuvan'Ghjacumu, Fledrich, Robert, Fonte, Cosima, Branchu, Julien, Goulard, Marie, de Waele, Catherine, Charbonnier, Frédéric, Sereda, Michael W., Baulieu, Etienne-Emile, Schumacher, Michael, Bernard, Sophie, and Massaad, Charbel

Published
2012

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