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1,462 results on '"Baumgärtner W"'

6. Could hamsters be a model for respiratory post-acute sequelae of SARS-CoV-2?

Author

Heydemann, L., primary, Ciurkiewicz, M., additional, Störk, T., additional, Hülskötter, K., additional, Gregor, K.M., additional, Michaely, L.M., additional, Reineking, W., additional, Schreiner, T., additional, Volz, A., additional, von Köckritz-Blickwede, M., additional, Tuchel, T., additional, Meyer zu Natrup, C., additional, Schünemann, L.M., additional, Clever, S., additional, Baumgärtner, W., additional, and Armando, F., additional

Published
2024
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8. CK8+ alveolar intermediate differentiation cells are features of alveolar regeneration in SARS-CoV-2 infected hamsters

Author

Armando, F, additional, Heydemann, L, additional, Beythien, G, additional, Becker, K, additional, Schughart, K, additional, Stanelle-Bertram, S, additional, Schaumburg, B, additional, Mounogou-Kouassi, N, additional, Beck, S, additional, Zickler, M, additional, Kühnel, M, additional, Gabriel, G, additional, Beineke, A, additional, Baumgärtner, W, additional, and Ciurkiewicz, M, additional

Published
2023
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9. Immunisierung mit MVA-Vektorimpfstoffen schützt K18-hACE2 Mäuse vor SARS- CoV-2 vermittelten, pathologischen Veränderungen im ZNS

Author

Rosiak, M., additional, Hülskötter, K., additional, Beythien, G., additional, Allnoch, L., additional, Becker, K., additional, Clever, S., additional, Schünemann, L., additional, Meyer zu Natrup, C., additional, Tscherne, A., additional, Limpinsel, L., additional, Tuchel, T., additional, Sutter, G., additional, Volz, A., additional, Baumgärtner, W., additional, and Ciurkiewicz, M., additional

Published
2023
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15. The attenuated Rift Valley fever virus strain clone 13 induces encephalitis in type 1 interferon competent mice

Author

Michaely, L.M., primary, Schuwerk, L., additional, Allnoch, L., additional, Schön, K., additional, Waltl, I., additional, Larsen, P.K., additional, Pavlou, A., additional, Prajeeth, C.K., additional, Rimmelzwaan, G.F., additional, Becker, S.C., additional, Kalinke, U., additional, Baumgärtner, W., additional, and Gerhauser, I., additional

Published
2023
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16. Detection of double-stranded RNA intermediates of four major SARS-CoV-2 variants in formalin-fixed paraffin-embedded lung tissue of Syrian golden hamsters using monoclonal antibodies

Author

Beythien, G., primary, Roi, M. de le, additional, Armando, F., additional, Allnoch, L., additional, Heydemann, L., additional, Rosiak, M., additional, Becker, S., additional, Kaiser, F.K., additional, Gonzalez-Hernandez, M., additional, Lamers, M.M., additional, Haagmans, B.L., additional, Guilfoyle, K., additional, van Amerongen, G., additional, Ciurkiewicz, M., additional, Osterhaus, A.D.M.E., additional, and Baumgärtner, W., additional

Published
2023
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17. Retinal pathology in COVID-19: will animal models help us?

Author

Gregor, K.M., primary, Ciurkiewicz, M., additional, Rosiak, M., additional, Volz, A., additional, Allnoch, L., additional, Clever, S., additional, Zu Natrup, C. Meyer, additional, Schünemann, L.M., additional, Armando, F., additional, Gerhauser, I., additional, Becker, K., additional, Beythien, G., additional, Gabriel, G., additional, Schulz, C., additional, von Köckritz-Blickwede, M., additional, and Baumgärtner, W., additional

Published
2023
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18. SARS-CoV-2 (B1.1.529) Omicron variant: what has changed in the nose?

Author

Ciurkiewicz, M., primary, Armando, F., additional, Beythien, G., additional, Allnoch, L., additional, Heydemann, L., additional, Rosiak, M., additional, Becker, S., additional, Kaiser, F.K., additional, Gonzalez-Hernandez, M., additional, Lamers, M.M., additional, Haagmans, B.L., additional, Guilfoyle, K., additional, van Amerongen, G., additional, Osterhaus, A.D.M.E., additional, and Baumgärtner, W., additional

Published
2023
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19. Investigation on epithelial to mesenchymal transition (EMT) of EcPV-2 positive equine vulvar squamous cell carcinoma: a spontaneous model for human genital carcinomas

Author

Armando, F., primary, De Paolis, L., additional, Mecocci, S., additional, Puff, C., additional, Baumgärtner, W., additional, Ciurkiewicz, M., additional, De Ciucis, C.G., additional, Corradi, A., additional, Ghelardi, A., additional, Cappelli, K., additional, Passeri, B., additional, and Razzuoli, E., additional

Published
2023
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24. Porcine Forebrain Vacuolization Associated with Wasting in Pigs: A Novel Pathological Outcome Associated with Vitamin–Mineral Deficiency?

Author

Ruiz-Riera, E., Vidal, E., Canturri, A., Lehmbecker, A., Cuvertoret, M., Lopez-Figueroa, C., Baumgärtner, W., Domingo, M., and Segalés, J.

Subjects
PROSENCEPHALON, GROWTH disorders, CEREBELLAR nuclei, SWINE, ELECTRON detection, THALAMIC nuclei, MYELIN sheath
Abstract

Simple Summary: The term wasting is a clinical name describing a physical condition characterized by growth retardation, usually of multifactorial origin. The present study describes an apparently new condition of pigs characterized clinically by wasting and pathologically by vacuolization of the brain. During 2016–2018, animals from eight farms were weaned in good body condition, and after 1–2 weeks, they started losing weight. To investigate potential causes of this condition, apparently sick and healthy pigs from each herd of eight affected farms were studied by means of histopathology, transmission electron microscopy and detection of usual infectious agents. Histopathologically, the most consistent lesion was neuropil vacuolization of the prosencephalon, mainly located in the thalamic nuclei and in the transition between the white and grey matter of the neocortex. Electron microscopy of some of these sick animals showed preserved axons, with dilated myelin sheaths (interpreted as edema of myelin sheath). The literature suggests this lesion type is linked to congenital or metabolic (toxic/deficiency) scenarios. The present case was probably a vitamin/mineral deficiency since supplementation with nutritional complexes solved the problem. The term wasting refers to a clinical sign used to describe a physical condition characterized by growth retardation, usually of multifactorial origin. The objective of the present study was to describe for the first time a pathological process characterized by forebrain neuropil vacuolization in pigs showing wasting without conspicuous neurological signs. To characterize the lesions pathologically, affected and non-affected pigs from eight of these farms were investigated. Histologically, the most consistent lesion was neuropil vacuolization of the prosencephalon, mainly located in the thalamic nuclei and in the transition between the white and grey matter of the neocortex (40/56 in sick and 4/30 in healthy pigs). In the most severe cases, the vacuolation also involved the midbrain, cerebellar nuclei and, to a lesser extent, the medulla oblongata. Vacuolization of the forebrain was associated with pigs experiencing marked emaciation and growth retardation. Although the specific cause of the present case remained unknown, the preventive use of multivitamin and mineral complexes in drinking water ameliorated the condition, strongly suggesting a metabolic origin of the observed condition. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Investigation into diseases in free-ranging ring-necked pheasants (Phasianus colchicus) in northwestern Germany during population decline with special reference to infectious pathogens

Author

Curland, N., Gethöffer, F., van Neer, A., Ziegler, L., Heffels-Redmann, U., Lierz, M., Baumgärtner, W., Wohlsein, P., Völker, I., Lapp, S., Bello, A., Pfankuche, V. M., Braune, S., Runge, M., Moss, A., Rautenschlein, S., Jung, A., Teske, L., Strube, C., Schulz, J., Bodewes, R., Osterhaus, A. D. M. E., and Siebert, U.

Published
2018
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27. Infektion des zentralen Nervensystems mit aviärem Influenza-A-Virus des Subtyps H5N8 in Seehunden (Phoca vitulina) an der deutschen Nordseeküste

Author

Lombardo, MS, additional, de le Roi, M, additional, Postel, A, additional, King, J, additional, Kaiser, FranziskaK, additional, Kennedy, J, additional, Reineking, W, additional, Harder, T, additional, Pohlmann, A, additional, Gerlach, T, additional, Rimmelzwaan, G, additional, Rohner, S, additional, Striewe, LC, additional, Gross, S, additional, Schick, LA, additional, Klink, JC, additional, Kramer, K, additional, Osterhaus, ADME, additional, Beer, M, additional, Siebert, U, additional, Becher, P, additional, and Baumgärtner, W, additional

Published
2022
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42. Investigations on SARS-CoV-2 Susceptibility of Domestic and Wild Animals Using Primary Cell Culture Models Derived from the Upper and Lower Respiratory Tract

Author

Färber, I., Krüger, J., Rocha, C., Armando, F., Köckritz-Blickwede, M. von, Pöhlmann, S., Braun, Armin, Baumgärtner, W., Runft, S., Krüger, N., and Publica

Subjects
animals, CTSL, SARS-CoV-2, tissue explants, primary cell cultures, ACE2, air-liquid interface, zoonosis, respiratory tract, TMPRSS2
Abstract

Several animal species are susceptible to SARS-CoV-2 infection, as documented by case reports and serological and in vivo infection studies. However, the susceptibility of many animal species remains unknown. Furthermore, the expression patterns of SARS-CoV-2 entry factors, such as the receptor angiotensin-converting enzyme 2 (ACE2), as well as transmembrane protease serine subtype 2 (TMPRSS2) and cathepsin L (CTSL), cellular proteases involved in SARS-CoV-2 spike protein activation, are largely unexplored in most species. Here, we generated primary cell cultures from the respiratory tract of domestic and wildlife animals to assess their susceptibility to SARS-CoV-2 infection. Additionally, the presence of ACE2, TMPRSS2 and CTSL within respiratory tract compartments was investigated in a range of animals, some with unknown susceptibility to SARS-CoV-2. Productive viral replication was observed in the nasal mucosa explants and precision-cut lung slices from dogs and hamsters, whereas culture models from ferrets and multiple ungulate species were non-permissive to infection. Overall, whereas TMPRSS2 and CTSL were equally expressed in the respiratory tract, the expression levels of ACE2 were more variable, suggesting that a restricted availability of ACE2 may contribute to reduced susceptibility. Summarized, the experimental infection of primary respiratory tract cell cultures, as well as an analysis of entry-factor distribution, enable screening for SARS-CoV-2 animal reservoirs.

Published
2022

43. SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of Hamsters

Author

Schreiner, T., Allnoch, L., Beythien, G., Marek, K., Becker, K., Schaudien, Dirk, Stanelle-Bertram, S., Schaumburg, B., Kouassi, N.M., Beck, S., Zickler, M., Gabriel, G., Baumgärtner, W., Armando, F., Ciurkiewicz, M., and Publica

Subjects
histology, golden Syrian hamster, SARS-CoV-2, immunohistochemistry, transmission electron microscopy, cilia, COVID-19, trachea, scanning electron microscopy, respiratory epithelium
Abstract

Similar to many other respiratory viruses, SARS-CoV-2 targets the ciliated cells of the respiratory epithelium and compromises mucociliary clearance, thereby facilitating spread to the lungs and paving the way for secondary infections. A detailed understanding of mechanism involved in ciliary loss and subsequent regeneration is crucial to assess the possible long-term consequences of COVID-19. The aim of this study was to characterize the sequence of histological and ultrastructural changes observed in the ciliated epithelium during and after SARS-CoV-2 infection in the golden Syrian hamster model. We show that acute infection induces a severe, transient loss of cilia, which is, at least in part, caused by cilia internalization. Internalized cilia colocalize with membrane invaginations, facilitating virus entry into the cell. Infection also results in a progressive decline in cells expressing the regulator of ciliogenesis FOXJ1, which persists beyond virus clearance and the termination of inflammatory changes. Ciliary loss triggers the mobilization of p73+ and CK14+ basal cells, which ceases after regeneration of the cilia. Although ciliation is restored after two weeks despite the lack of FOXJ1, an increased frequency of cilia with ultrastructural alterations indicative of secondary ciliary dyskinesia is observed. In summary, the work provides new insights into SARS-CoV-2 pathogenesis and expands our understanding of virally induced damage to defense mechanisms in the conducting airways.

Published
2022

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