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1. The Role of Hyperdense Basilar Artery Sign in Predicting Outcome of Acute Basilar Artery Occlusion within Twelve Hours of Onset

Author

Liu, Xinfeng, Wang, Guoping, Nogueira, Raul G., Qureshi, Adnan I., Baxter, Blaise W., Xu, Gelin, Yan, Xiaoyan, Gao, Feng, Jiao, Liqun, Qun, Sen, Wang, Zi, Chen, Juan, Ye, Ruidong, Zhang, Yongwei, Wu, Cangjun, Li, Rui, Fang, Chuanqing, Deng, Kexue, Yuan, Shuya, Zheng, Menglong, Chen, Hongbing, Zhang, Guang, Bao, Wei, Han, Hongxing, Yuan, Guangxiong, Wen, Changming, Zhou, Peiyang, Chen, Wenhuo, Zeng, Guoyong, Xu, Hui, Li, Yuwen, Ma, Zhengfei, Yu, Chuanqing, Su, Junfeng, Zhou, Zhiming, Chen, Zhongjun, Liao, Geng, Sun, Yaxuan, Ren, Youquan, Zhang, Hui, Chen, Jie, Yue, Xincan, Ma, Xiuyao, Xiao, GuoDong, Wang, Li, Liu, Rui, Yang, Weimin, Liu, Wenhua, Liu, Yong, Guo, Fuqiang, Cai, Xueli, Yin, Bo, Li, Jinglun, Fang, Pu, Shen, Chunyun, Ni, Chuyuan, Wang, Hui, Liu, Liang, Li, Kai, Cui, Tao, Wang, Hao, Gao, Jun, Yi, Tingyu, Wang, Youmeng, Wang, Tao, Shi, Xueying, Cao, Zhihua, Long, Chen, Chen, Li, Zhang, Chi, Zhai, Gichao, Zhang, Xia, Liang, Xiushan, Li, Qingsong, Meng, Yuhan, Tao, Jianbo, Zhu, Zhenzhu, Cheng, Yuedong, Zhang, Meng, Zhou, Tong, Wang, Jing, Zhang, Yali, Hu, Xiaohui, Tao, Chunrong, Yin, Yamei, Liu, Huanhuan, Tan, Xianhong, Hou, Siyang, Xie, Sanpin, Huo, Longwen, Zhu, Yuyou, Gong, Daokai, and Hu, Wei

Published
2024
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2. The WOVEN trial: Wingspan One-year Vascular Events and Neurologic Outcomes

Author

Alexander, Michael J, Zauner, Alois, Gupta, Rishi, Alshekhlee, Amer, Fraser, Justin F, Toth, Gabor, Given, Curtis, Mackenzie, Larami, Kott, Brian, Hassan, Ameer E, Shownkeen, Harish, Baxter, Blaise W, Callison, R Charles, and Yu, Wengui

Subjects
Neurosciences, Clinical Research, Brain Disorders, Clinical Trials and Supportive Activities, Stroke, Aged, Cohort Studies, Constriction, Pathologic, Female, Follow-Up Studies, Humans, Intracranial Arteriosclerosis, Male, Middle Aged, Mortality, Nervous System Diseases, Stents, Treatment Outcome, stent, stenosis, atherosclerosis, intervention, stroke
Abstract

BackgroundPrior studies evaluating the Wingspan stent for treatment of symptomatic intracranial atherosclerotic disease have included patients with a spectrum of both on-label and off-label indications for the stent. The WEAVE trial assessed 152 patients stented with the Wingspan stent strictly by its current on-label indication and found a 2.6% periprocedural stroke and death rate.ObjectiveThis WOVEN study assesses the 1-year follow-up from this cohort.MethodsTwelve of the original 24 sites enrolling patients in the WEAVE trial performed follow-up chart review and imaging analysis up to 1 year after stenting. Assessment of delayed stroke and death was made in 129 patients, as well as vascular imaging follow-up to assess for in-stent re-stenosis.ResultsIn the 1-year follow-up period, seven patients had a stroke (six minor, one major). Subsequent to the periprocedural period, no deaths were recorded in the cohort. Including the four patients who had periprocedural events in the WEAVE study, there were 11 strokes or deaths of the 129 patients (8.5%) at the 1-year follow-up.ConclusionsThe WOVEN study provides the 1-year follow-up on a cohort of 129 patients who were stented according to the current on-label use. It provides a more homogeneous patient group for analysis than prior studies, and demonstrates a relatively low 8.5% 1-year stroke and death rate in stented patients.

Published
2021

3. The Tandem Occlusion

Author

Chung, Charlotte Y., Jiang, Liwei, Hui, Ferdinand K., Baxter, Blaise William, Hui, Ferdinand K., editor, Spiotta, Alejandro M., editor, Alexander, Michael J., editor, Hanel, Ricardo A., editor, and Baxter, Blaise William, editor

Published
2021
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4. WEAVE Trial

Author

Alexander, Michael J, Zauner, Alois, Chaloupka, John C, Baxter, Blaise, Callison, Richard C, Gupta, Rishi, Song, Shlee S, Yu, Wengui, Feng, Lei, Bonovich, David, Toth, Gabor, Kott, Brian, Veznedaroglu, Erol, Ringer, Andrew, Meyers, Philip, Agola, John, Ghodke, Basavaraj, Alhajeri, Abdulnasser, Fraser, Justin, Given, Curtis, de Valle, Eric Lopez, Shah, Qaisar, Nesbit, Gary, Hassan, Ameer, Grobelny, Thomas, Fessler, Richard, and Shownkeen, Harish

Subjects
Brain Disorders, Clinical Trials and Supportive Activities, Cardiovascular, Clinical Research, Stroke, Neurosciences, Atherosclerosis, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Aged, Angioplasty, Female, Humans, Intracranial Arteriosclerosis, Intraoperative Complications, Male, Middle Aged, Prospective Studies, Stents, Treatment Outcome, angioplasty, antiplatelet therapy, atherosclerosis, patient selection, stents, WEAVE Trial Sites and Interventionalists, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and Purpose- The WEAVE trial (Wingspan Stent System Post Market Surveillance) is a postmarket surveillance trial mandated by the Food and Drug Administration to assess the periprocedural safety of the Wingspan Stent system in the treatment of symptomatic intracranial atherosclerotic disease. Methods- A total of 152 consecutive patients who met the Food and Drug Administration on-label usage criteria were enrolled at 24 hospitals and underwent angioplasty and stenting with the Wingspan stent. On-label criteria included age 22 to 80 years, symptomatic intracranial atherosclerotic stenosis of 70% to 99%, baseline modified Rankin Scale score ≤3, ≥2 strokes in the vascular territory of the stenotic lesion with at least 1 stroke while on medical therapy, and stenting of the lesion ≥8 days after the last stroke. The primary analysis assessed the periprocedural stroke, bleed, and death rate within 72 hours of the procedure with adjudication by a core study Stroke Neurologist. Results- The trial was stopped early after interim analysis of 152 consecutive patients demonstrated a lower than expected 2.6% (4/152 patients) periprocedural stroke, bleed, and death rate. This was lower than the 4% periprocedural primary event safety benchmark set for the interim analysis in the study. A total of 97.4% (148/152) patients were event-free at 72 hours, 1.3% (2/152) had nonfatal strokes, and 1.3% (2/152) of patients died. Conclusions- With experienced interventionalists, and proper patient selection following the on-label usage guidelines, the use of the Wingspan stent for intracranial atherosclerotic disease demonstrated a low periprocedural complication rate and excellent safety profile. This is the largest on-label, multicenter, prospective trial of the Wingspan stent system to date with the lowest reported complication rate. Clinical Trial Registration- URL: https://www.clinicaltrials.gov . Unique identifier: NCT02034058.

Published
2019

5. WEAVE Trial: Final Results in 152 On-Label Patients.

Author

Alexander, Michael J, Zauner, Alois, Chaloupka, John C, Baxter, Blaise, Callison, Richard C, Gupta, Rishi, Song, Shlee S, Yu, Wengui, and WEAVE Trial Sites and Interventionalists

Subjects
WEAVE Trial Sites and Interventionalists, Humans, Intracranial Arteriosclerosis, Intraoperative Complications, Treatment Outcome, Angioplasty, Prospective Studies, Stents, Aged, Middle Aged, Female, Male, angioplasty, antiplatelet therapy, atherosclerosis, patient selection, stents, Neurology & Neurosurgery, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurosciences
Abstract

Background and Purpose- The WEAVE trial (Wingspan Stent System Post Market Surveillance) is a postmarket surveillance trial mandated by the Food and Drug Administration to assess the periprocedural safety of the Wingspan Stent system in the treatment of symptomatic intracranial atherosclerotic disease. Methods- A total of 152 consecutive patients who met the Food and Drug Administration on-label usage criteria were enrolled at 24 hospitals and underwent angioplasty and stenting with the Wingspan stent. On-label criteria included age 22 to 80 years, symptomatic intracranial atherosclerotic stenosis of 70% to 99%, baseline modified Rankin Scale score ≤3, ≥2 strokes in the vascular territory of the stenotic lesion with at least 1 stroke while on medical therapy, and stenting of the lesion ≥8 days after the last stroke. The primary analysis assessed the periprocedural stroke, bleed, and death rate within 72 hours of the procedure with adjudication by a core study Stroke Neurologist. Results- The trial was stopped early after interim analysis of 152 consecutive patients demonstrated a lower than expected 2.6% (4/152 patients) periprocedural stroke, bleed, and death rate. This was lower than the 4% periprocedural primary event safety benchmark set for the interim analysis in the study. A total of 97.4% (148/152) patients were event-free at 72 hours, 1.3% (2/152) had nonfatal strokes, and 1.3% (2/152) of patients died. Conclusions- With experienced interventionalists, and proper patient selection following the on-label usage guidelines, the use of the Wingspan stent for intracranial atherosclerotic disease demonstrated a low periprocedural complication rate and excellent safety profile. This is the largest on-label, multicenter, prospective trial of the Wingspan stent system to date with the lowest reported complication rate. Clinical Trial Registration- URL: https://www.clinicaltrials.gov . Unique identifier: NCT02034058.

Published
2019

6. Trevo 2000: Results of a Large Real-World Registry for Stent Retriever for Acute Ischemic Stroke.

Author

Binning, Mandy, Bartolini, Bruno, Baxter, Blaise, Budzik, Ronald, English, Joey, Gupta, Rishi, Hedayat, Hirad, Krajina, Antonin, Liebeskind, David, Nogueira, Raul, Shields, Ryan, and Veznedaroglu, Erol

Subjects
endovascular treatment, stroke, ischemic, thrombectomy, Aged, Aged, 80 and over, Brain Ischemia, Databases, Factual, Disability Evaluation, Endovascular Procedures, Female, Humans, Male, Middle Aged, Prospective Studies, Prosthesis Design, Recovery of Function, Registries, Risk Factors, Stents, Stroke, Thrombectomy, Time Factors, Treatment Outcome
Abstract

Background Recent randomized controlled trials show benefit of thrombectomy for large vessel occlusion in stroke. Real-world data aid in assessing reproducibility of outcomes outside of clinical trials. The Trevo Retriever Registry is a multicenter, international, prospective study designed to assess outcomes in a large cohort of patients. Methods and Results The Trevo Registry is a prospective database of patients with large vessel occlusion treated with the Trevo device as the first device. The primary end point is revascularization based on modified Thrombolysis in Cerebral Infarction score and secondary end points include 90-day modified Rankin Scale, 90-day mortality, neurological deterioration at 24 hours, and device/procedure related adverse events. Year 2008 patients were enrolled at 76 centers in 12 countries. Median admission National Institutes of Health Stroke Scale was 16 (interquartile range, 11-20). Occlusion sites were internal carotid artery (17.8%), middle cerebral artery (73.5%), posterior circulation (7.1%), and distal vascular locations (1.6%). A modified Thrombolysis in Cerebral Infarction 2b or 3 was achieved in 92.8% (95% CI, 91.6, 93.9) of procedures, with 55.3% (95% CI, 53.1, 57.5) of patients achieving modified Rankin Scale ≤2 at 3 months. Patients meeting revised 2015 American Heart Association criteria for thrombectomy had a 59.7% (95% CI , 56.0; 63.4) modified Rankin Scale 0 to 2 at 3 months, whereas 51.4% treated outside of American Heart Association criteria had modified Rankin Scale 0 to 2. 51.4% (95% CI , 49.6, 55.4). Symptomatic intracranial hemorrhage rate was 1.7% (95% CI , 1.2, 2.4). Conclusions The Trevo Retriever Registry represents real-world data with stent retriever. The registry demonstrates similar reperfusion rates and outcomes in the community compared with rigorous centrally adjudicated clinical trials. Future subgroup analysis of this cohort will assist in identifying areas of future research. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique identifier: NCT 02040259.

Published
2018

7. Interhospital Transfer Before Thrombectomy Is Associated With Delayed Treatment and Worse Outcome in the STRATIS Registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke)

Author

Froehler, Michael T, Saver, Jeffrey L, Zaidat, Osama O, Jahan, Reza, Aziz-Sultan, Mohammad Ali, Klucznik, Richard P, Haussen, Diogo C, Hellinger, Frank R, Yavagal, Dileep R, Yao, Tom L, Liebeskind, David S, Jadhav, Ashutosh P, Gupta, Rishi, Hassan, Ameer E, Martin, Coleman O, Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G, Gandhi, Ravi H, Peterson, Eric C, Dashti, Shervin R, Given, Curtis A, Mehta, Brijesh P, Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H, Kvamme, Peter, Grobelny, Thomas J, Hussain, Muhammad S, Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J, Ecker, Robert D, Schirmer, Clemens M, Sauvageau, Eric, Abou-Chebl, Alex, Derdeyn, Colin P, Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H, Dumont, Travis M, Alhajeri, Abdulnasser, Taqi, M Asif, Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S, Chitale, Rohan, Deshaies, Eric M, Robinson, David H, Kallmes, David F, Baxter, Blaise W, Jumaa, Mouhammad A, Sunenshine, Peter, Majjhoo, Aniel, English, Joey D, Suzuki, Shuichi, Fessler, Richard D, Almandoz, Josser E Delgado, Martin, Jerry C, and Mueller-Kronast, Nils H

Subjects
Stroke, Clinical Research, Brain Disorders, Endovascular Procedures, Hospitals, Humans, Ischemia, Patient Transfer, Prospective Studies, Registries, Survival Analysis, Thrombectomy, Time Factors, Treatment Outcome, emergency medical services, endovascular treatment, ischemic stroke, stent retriever, systems of care, STRATIS Investigators, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundEndovascular treatment with mechanical thrombectomy (MT) is beneficial for patients with acute stroke suffering a large-vessel occlusion, although treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared with direct presentation.MethodsSTRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter, observational, single-arm study of real-world MT for acute stroke because of anterior-circulation large-vessel occlusion performed at 55 sites over 2 years, including 1000 patients with severe stroke and treated within 8 hours. Patients underwent MT with or without intravenous tissue plasminogen activator and were admitted to endovascular-capable centers via either interhospital transfer or direct presentation. The primary clinical outcome was functional independence (modified Rankin Score 0-2) at 90 days. We assessed (1) real-world time metrics of stroke care delivery, (2) outcome differences between direct and transfer patients undergoing MT, and (3) the potential impact of local hospital bypass.ResultsA total of 984 patients were analyzed. Median onset-to-revascularization time was 202.0 minutes for direct versus 311.5 minutes for transfer patients (P

Published
2017

9. The Role of Hyperdense Basilar Artery Sign in Predicting Outcome of Acute Basilar Artery Occlusion within Twelve Hours of Onset

Author

Hu, Xiaohui, primary, Su, Junfeng, additional, Chen, Li, additional, Li, Rui, additional, Tao, Chunrong, additional, Yin, Yamei, additional, Liu, Huanhuan, additional, Tan, Xianhong, additional, Hou, Siyang, additional, Xie, Sanpin, additional, Huo, Longwen, additional, Zhu, Yuyou, additional, Gong, Daokai, additional, Hu, Wei, additional, Liu, Xinfeng, additional, Wang, Guoping, additional, Nogueira, Raul G., additional, Qureshi, Adnan I., additional, Baxter, Blaise W., additional, Xu, Gelin, additional, Yan, Xiaoyan, additional, Gao, Feng, additional, Jiao, Liqun, additional, Qun, Sen, additional, Wang, Zi, additional, Chen, Juan, additional, Ye, Ruidong, additional, Zhang, Yongwei, additional, Wu, Cangjun, additional, Fang, Chuanqing, additional, Deng, Kexue, additional, Yuan, Shuya, additional, Zheng, Menglong, additional, Chen, Hongbing, additional, Zhang, Guang, additional, Bao, Wei, additional, Han, Hongxing, additional, Yuan, Guangxiong, additional, Wen, Changming, additional, Zhou, Peiyang, additional, Chen, Wenhuo, additional, Zeng, Guoyong, additional, Xu, Hui, additional, Li, Yuwen, additional, Ma, Zhengfei, additional, Yu, Chuanqing, additional, Zhou, Zhiming, additional, Chen, Zhongjun, additional, Liao, Geng, additional, Sun, Yaxuan, additional, Ren, Youquan, additional, Zhang, Hui, additional, Chen, Jie, additional, Yue, Xincan, additional, Ma, Xiuyao, additional, Xiao, GuoDong, additional, Wang, Li, additional, Liu, Rui, additional, Yang, Weimin, additional, Liu, Wenhua, additional, Liu, Yong, additional, Guo, Fuqiang, additional, Cai, Xueli, additional, Yin, Bo, additional, Li, Jinglun, additional, Fang, Pu, additional, Shen, Chunyun, additional, Ni, Chuyuan, additional, Wang, Hui, additional, Liu, Liang, additional, Li, Kai, additional, Cui, Tao, additional, Wang, Hao, additional, Gao, Jun, additional, Yi, Tingyu, additional, Wang, Youmeng, additional, Wang, Tao, additional, Shi, Xueying, additional, Cao, Zhihua, additional, Long, Chen, additional, Zhang, Chi, additional, Zhai, Gichao, additional, Zhang, Xia, additional, Liang, Xiushan, additional, Li, Qingsong, additional, Meng, Yuhan, additional, Tao, Jianbo, additional, Zhu, Zhenzhu, additional, Cheng, Yuedong, additional, Zhang, Meng, additional, Zhou, Tong, additional, Wang, Jing, additional, and Zhang, Yali, additional

Published
2024
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10. Rapid learning curve for Solitaire FR stent retriever therapy: evidence from roll-in and randomised patients in the SWIFT trial

Author

Sheth, Sunil A, Jahan, Reza, Levy, Elad I, Jovin, Tudor G, Baxter, Blaise, Nogueira, Raul G, Clark, Wayne, Budzik, Ronald, Zaidat, Osama O, and Saver, Jeffrey L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Bioengineering, Clinical Trials and Supportive Activities, Stroke, Neurosciences, Brain Disorders, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aged, Aged, 80 and over, Brain Ischemia, Female, Humans, Learning Curve, Male, Middle Aged, Prospective Studies, Stents, Survival Rate, Thrombectomy, SWIFT Trialists, Angiography, Intervention, Technique, Clinical sciences
Abstract

BackgroundIn light of recent positive trial data for endovascular therapy in acute ischemic stroke (AIS), stent retriever use by practitioners without prior experience with these devices may become more common.ObjectiveTo assess the safety and efficacy of thrombectomy for AIS using Solitaire for patients treated in the roll-in period of the Solitaire With the Intention For Thrombectomy (SWIFT) trial, which represented the first clinical use of the device for these interventionalists.MethodsProspectively collected demographic, clinical, and angiographic data on patients treated in the initial roll-in and subsequent randomized phases of the SWIFT study were collected and analyzed. Key statistical analyses were validated by an independent external statistician.ResultsPatients in the roll-in period achieved equivalently high rates of reperfusion (55%) compared with those treated with the device in the randomized phase (61%). Rates of adverse events were comparable (13% vs. 9%). Rates of good neurological outcome were equivalent between the roll-in and randomized patients treated with Solitaire (63% vs. 58%). Including the roll-in patients strengthened the conclusions of the study, that reperfusion rates without symptomatic hemorrhage with Solitaire were greater than with Merci (59% vs. 24%, p

Published
2016

11. Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale

Author

Chaisinanunkul, Napasri, Adeoye, Opeolu, Lewis, Roger J, Grotta, James C, Broderick, Joseph, Jovin, Tudor G, Nogueira, Raul G, Elm, Jordan J, Graves, Todd, Berry, Scott, Lees, Kennedy R, Barreto, Andrew D, Saver, Jeffrey L, Furlan, Anthony, Baxter, Blaise, Lutsep, Helmi L, Ribo, Marc, Jansen, Olav, Gupta, Rishi, and Pereira, Vitor Mendes

Subjects
Epidemiology, Health Sciences, Brain Disorders, Clinical Trials and Supportive Activities, Neurosciences, Stroke, Cerebrovascular, Clinical Research, Good Health and Well Being, Clinical Trials as Topic, Humans, Patient-Centered Care, Severity of Illness Index, Treatment Outcome, blood pressure, stroke, stroke management, thrombolysis, DAWN Trial and MOST Trial Steering Committees, Additional contributors from DAWN Trial Steering Committee, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

Background and purposeAlthough the modified Rankin Scale (mRS) is the most commonly used primary end point in acute stroke trials, its power is limited when analyzed in dichotomized fashion and its indication of effect size challenging to interpret when analyzed ordinally. Weighting the 7 Rankin levels by utilities may improve scale interpretability while preserving statistical power.MethodsA utility-weighted mRS (UW-mRS) was derived by averaging values from time-tradeoff (patient centered) and person-tradeoff (clinician centered) studies. The UW-mRS, standard ordinal mRS, and dichotomized mRS were applied to 11 trials or meta-analyses of acute stroke treatments, including lytic, endovascular reperfusion, blood pressure moderation, and hemicraniectomy interventions.ResultsUtility values were 1.0 for mRS level 0; 0.91 for mRS level 1; 0.76 for mRS level 2; 0.65 for mRS level 3; 0.33 for mRS level 4; 0 for mRS level 5; and 0 for mRS level 6. For trials with unidirectional treatment effects, the UW-mRS paralleled the ordinal mRS and outperformed dichotomous mRS analyses. Both the UW-mRS and the ordinal mRS were statistically significant in 6 of 8 unidirectional effect trials, whereas dichotomous analyses were statistically significant in 2 to 4 of 8. In bidirectional effect trials, both the UW-mRS and ordinal tests captured the divergent treatment effects by showing neutral results, whereas some dichotomized analyses showed positive results. Mean utility differences in trials with statistically significant positive results ranged from 0.026 to 0.249.ConclusionsA UW-mRS performs similar to the standard ordinal mRS in detecting treatment effects in actual stroke trials and ensures the quantitative outcome is a valid reflection of patient-centered benefits.

Published
2015

12. Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke: From the American Association of Neurological Surgeons (AANS), American Society of Neuroradiology (ASNR), Cardiovascular and Interventional Radiology Society of Europe (CIRSE), Canadian Interventional Radiology Association (CIRA), Congress of Neurological Surgeons (CNS), European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), European Stroke Organization (ESO), Society for Cardiovascular Angiography and Interventions (SCAI), Society of Interventional Radiology (SIR), Society of NeuroInterventional Surgery (SNIS), and World Stroke Organization (WSO)

Author

Sacks, David, Baxter, Blaise, Campbell, Bruce C.V., Carpenter, Jeffrey S., Cognard, Christophe, Dippel, Diederik, Eesa, Muneer, Fischer, Urs, Hausegger, Klaus, Hirsch, Joshua A., Hussain, Muhammad Shazam, Jansen, Olav, Jayaraman, Mahesh V., Khalessi, Alexander A., Kluck, Bryan W., Lavine, Sean, Meyers, Philip M., Ramee, Stephen, Rüfenacht, Daniel A., Schirmer, Clemens M., and Vorwerk, Dierk

Published
2018
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15. Factors Associated With the Decision-Making on Endovascular Thrombectomy for the Management of Acute Ischemic Stroke

Author

Saposnik, Gustavo, Menon, Bijoy K., Kashani, Nima, Wilson, Alexis T., Yoshimura, Shinichi, Campbell, Bruce C.V., Baxter, Blaise, Rabinstein, Alejandro, Turjman, Francis, Fischer, Urs, Ospel, Johanna M., Mitchell, Peter J., Sylaja, Pillai N., Cherian, Mathew, Kim, Byungmoon, Heo, Ji-Hoe, Podlasek, Anna, Almekhlafi, Mohammed, Foss, Mona M., Demchuk, Andrew M., Hill, Michael D., and Goyal, Mayank

Published
2019
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16. Impact of Balloon Guide Catheter Use on Clinical and Angiographic Outcomes in the STRATIS Stroke Thrombectomy Registry

Author

Zaidat, Osama O., Mueller-Kronast, Nils H., Hassan, Ameer E., Haussen, Diogo C., Jadhav, Ashutosh P., Froehler, Michael T., Jahan, Reza, Ali Aziz-Sultan, Mohammad, Klucznik, Richard P., Saver, Jeffrey L., Hellinger, Frank R., Jr, Yavagal, Dileep R., Yao, Tom L., Gupta, Rishi, Martin, Coleman O., Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G., Gandhi, Ravi H., Peterson, Eric C., Dashti, Shervin, Given, Curtis A., II, Mehta, Brijesh P., Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H., Kvamme, Peter, Grobelny, Thomas J., Hussain, Muhammad Shazam, Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J., Ecker, Robert D., Schirmer, Clemens M., Sauvageau, Eric, Chebl, Alex Bou, Derdeyn, Colin P., Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H., Dumont, Travis M., Alhajeri, Abdulnasser, Taqi, Muhammad A., Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S., Chitale, Rohan, Deshaies, Eric M., Robinson, David, Kallmes, David F., Baxter, Blaise W., Jumaa, Mouhammed, Sunenshine, Peter, Majjhoo, Aniel, English, Joey D., Suzuki, Shuichi, Fessler, Richard D., Delgado-Almandoz, Josser, Martin, Jerry C., and Liebeskind, David S.

Published
2019
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17. Delayed Functional Independence After Neurothrombectomy (DEFIANT) score: analysis of the Trevo Retriever Registry.

Author

Jadhav, Ashutosh P., Desai, Shashvat M., Gupta, Rishi, Baxter, Blaise W., Bartolini, Bruno, Krajina, Antonin, English, Joey D., Nogueira, Raul G., Liebeskind, David S., Veznedaroglu, Erol, and Budzik, Ronald F.

Subjects
STROKE, FUNCTIONAL status, AGE distribution, ACQUISITION of data, RESEARCH funding, ENDOVASCULAR surgery, HEMORRHAGE
Abstract

Background Chronological heterogeneity in neurological improvement after endovascular thrombectomy (EVT) for large vessel occlusion (LVO) stroke is commonly observed in clinical practice. Understanding the temporal progression of functional independence after EVT, especially delayed functional independence in patients who do not improve early, is essential for prognostication and rehabilitation. We aim to determine the incidence of early functional independence (EFI) and delayed functional independence (DFI), identify associated predictors after EVT, and develop the Delayed Functional Independence After Neurothrombectomy (DEFIANT) score. Methods Demographic, clinical, radiological, treatment, and procedural information were analyzed from the Trevo Registry (patients undergoing EVT due to anterior LVO using the Trevo stent retriever). Incidence and predictors of EFI (modified Rankin Scale (mRS) score 0-2 at discharge) and DFI (mRS score 0-2 at 90 days in non-EFI patients) were analyzed. Results A total of 1623 patients met study criteria. EFI was observed in 45% (730) of patients. Among surviving non-EFI patients (884), DFI was observed in 35% (308). Younger age (p=0.003), lower discharge National Institutes of Health Stroke Scale (NIHSS) score (p<0.0001), and absence of any hemorrhage (p=0.021) were independent predictors of DFI. After age 60, the probability of DFI declines significantly with 5 year age increments (approximately 7% decline for every 5 years; p(DFI)= 1.3559-0.0699, p for slope=0.001). The DEFIANT score is available online (https://bit.ly/ 3KZRVq5). Conclusion Approximately 45% of patients experience EFI. About one-third of non-early improvers experience DFI. Younger age, lower discharge NIHSS score, and absence of any hemorrhage were independent predictors of DFI among non-early improvers. [ABSTRACT FROM AUTHOR]

Published
2023
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18. A Decade of Improvement in Door‐to‐Puncture Times for Mechanical Thrombectomy But Ongoing Stagnation in Prehospital Care

Author

Sun, Chung‐Huan, primary, Zaidat, Osama O., additional, Castonguay, Alicia C., additional, Veznedaroglu, Erol, additional, Budzik, Ronald F., additional, English, Joey, additional, Baxter, Blaise, additional, Nogueira, Raul G., additional, Krajina, Antonín, additional, Bartolini, Bruno, additional, Liebeskind, David S., additional, Smith, Wade, additional, Koenig, Matt, additional, Jenkins, Paul, additional, and Gupta, Rishi, additional

Published
2023
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19. Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion

Author

Tao, Chunrong, primary, Nogueira, Raul G., additional, Zhu, Yuyou, additional, Sun, Jun, additional, Han, Hongxing, additional, Yuan, Guangxiong, additional, Wen, Changming, additional, Zhou, Peiyang, additional, Chen, Wenhuo, additional, Zeng, Guoyong, additional, Li, Yuwen, additional, Ma, Zhengfei, additional, Yu, Chuanqing, additional, Su, Junfeng, additional, Zhou, Zhiming, additional, Chen, Zhongjun, additional, Liao, Geng, additional, Sun, Yaxuan, additional, Ren, Youquan, additional, Zhang, Hui, additional, Chen, Jie, additional, Yue, Xincan, additional, Xiao, Guodong, additional, Wang, Li, additional, Liu, Rui, additional, Liu, Wenhua, additional, Liu, Yong, additional, Zhang, Chao, additional, Liu, Tianlong, additional, Song, Jianlong, additional, Li, Rui, additional, Xu, Pengfei, additional, Yin, Yamei, additional, Wang, Guoping, additional, Baxter, Blaise, additional, Qureshi, Adnan I., additional, Liu, Xinfeng, additional, and Hu, Wei, additional

Published
2022
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20. Delayed Functional Independence After Neurothrombectomy (DEFIANT) score: analysis of the Trevo Retriever Registry

Author

Jadhav, Ashutosh P, primary, Desai, Shashvat M, additional, Gupta, Rishi, additional, Baxter, Blaise W, additional, Bartolini, Bruno, additional, Krajina, Antonin, additional, English, Joey D, additional, Nogueira, Raul G, additional, Liebeskind, David S, additional, Veznedaroglu, Erol, additional, and Budzik, Ronald F, additional

Published
2022
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22. Computed Tomographic Perfusion Predicts Poor Outcomes in a Randomized Trial of Endovascular Therapy

Author

Wannamaker, Robert, Guinand, Taurian, Menon, Bijoy K., Demchuk, Andrew, Goyal, Mayank, Frei, Donald, Bharatha, Aditya, Jovin, Tudor G., Shankar, Jai, Krings, Timo, Baxter, Blaise, Holmstedt, Christine, Swartz, Richard, Dowlatshahi, Dar, Chan, Richard, Tampieri, Donatella, Choe, Hana, Burns, Paul, Gentile, Nina, Rempel, Jeremy, Shuaib, Ashfaq, Buck, Brian, Bivard, Andrew, Hill, Michael, and Butcher, Kenneth

Published
2018
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23. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

Author

Nogueira, Raul G., Jadhav, Ashutosh P., Haussen, Diogo C., Bonafe, Alain, Budzik, Ronald F., Bhuva, Parita, Yavagal, Dileep R., Ribo, Marc, Cognard, Christophe, Hanel, Ricardo A., Sila, Cathy A., Hassan, Ameer E., Millan, Monica, Levy, Elad I., Mitchell, Peter, Chen, Michael, English, Joey D., Shah, Qaisar A., Silver, Frank L., Pereira, Vitor M., Mehta, Brijesh P., Baxter, Blaise W., Abraham, Michael G., Cardona, Pedro, Veznedaroglu, Erol, Hellinger, Frank R., Feng, Lei, Kirmani, Jawad F., Lopes, Demetrius K., Jankowitz, Brian T., Frankel, Michael R., Costalat, Vincent, Vora, Nirav A., Yoo, Albert J., Malik, Amer M., Furlan, Anthony J., Rubiera, Marta, Aghaebrahim, Amin, Olivot, Jean-Marc, Tekle, Wondwossen G., Shields, Ryan, Graves, Todd, Lewis, Roger J., Smith, Wade S., Liebeskind, David S., Saver, Jeffrey L., and Jovin, Tudor G.

Published
2018
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24. A multicenter study of the safety and effectiveness of mechanical thrombectomy for patients with acute ischemic stroke not meeting top-tier evidence criteria

Author

Goyal, Nitin, Tsivgoulis, Georgios, Frei, Donald, Turk, Aquilla, Baxter, Blaise, Froehler, Michael T, Mocco, J, Vachhani, Jay, Hoit, Daniel, Elijovich, Lucas, Loy, David, Turner, Raymond D, Mascitelli, Justin, Espaillat, Kiersten, Alexandrov, Andrei V, Alexandrov, Anne W, and Arthur, Adam S

Published
2018
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25. Post-thrombectomy management of the ELVO patient: Guidelines from the Society of NeuroInterventional Surgery

Author

Leslie-Mazwi, Thabele, Chen, Michael, Yi, Julia, Starke, Robert M, Hussain, M Shazam, Meyers, Philip M, McTaggart, Ryan A, Pride, G Lee, Ansari, Sameer, Abruzzo, Todd, Albani, Barbara, Arthur, Adam S, Baxter, Blaise W, Bulsara, Ketan R, Delgado Almandoz, Josser E, Gandhi, Chirag D, Heck, Don, Hetts, Steven W, Klucznik, Richard P, Jayaraman, Mahesh V, Lee, Seon-Kyu, Mack, William J, Mocco, J, Prestigiacomo, Charles, Patsalides, Athos, Rasmussen, Peter, Sunenshine, Peter, Frei, Donald, and Fraser, Justin F

Published
2017
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26. Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke: Primary Results of the STRATIS Registry

Author

Mueller-Kronast, Nils H., Zaidat, Osama O., Froehler, Michael T., Jahan, Reza, Aziz-Sultan, Mohammad Ali, Klucznik, Richard P., Saver, Jeffrey L., Hellinger, Frank R., Jr, Yavagal, Dileep R., Yao, Tom L., Liebeskind, David S., Jadhav, Ashutosh P., Gupta, Rishi, Hassan, Ameer E., Martin, Coleman O., Bozorgchami, Hormozd, Kaushal, Ritesh, Nogueira, Raul G., Gandhi, Ravi H., Peterson, Eric C., Dashti, Shervin R., Given, Curtis A., II, Mehta, Brijesh P., Deshmukh, Vivek, Starkman, Sidney, Linfante, Italo, McPherson, Scott H., Kvamme, Peter, Grobelny, Thomas J., Hussain, Muhammad S., Thacker, Ike, Vora, Nirav, Chen, Peng Roc, Monteith, Stephen J., Ecker, Robert D., Schirmer, Clemens M., Sauvageau, Eric, Abou-Chebl, Alex, Derdeyn, Colin P., Maidan, Lucian, Badruddin, Aamir, Siddiqui, Adnan H., Dumont, Travis M., Alhajeri, Abdulnasser, Taqi, M. Asif, Asi, Khaled, Carpenter, Jeffrey, Boulos, Alan, Jindal, Gaurav, Puri, Ajit S., Chitale, Rohan, Deshaies, Eric M., Robinson, David H., Kallmes, David F., Baxter, Blaise W., Jumaa, Mouhammad A., Sunenshine, Peter, Majjhoo, Aniel, English, Joey D., Suzuki, Shuichi, Fessler, Richard D., Delgado Almandoz, Josser E., Martin, Jerry C., and Haussen, Diogo C.

Published
2017
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28. Initial hospital management of patients with emergent large vessel occlusion (ELVO): report of the standards and guidelines committee of the Society of NeuroInterventional Surgery

Author

McTaggart, Ryan A, Ansari, Sameer A, Goyal, Mayank, Abruzzo, Todd A, Albani, Barb, Arthur, Adam J, Alexander, Michael J, Albuquerque, Felipe C, Baxter, Blaise, Bulsara, Ketan R, Chen, Michael, Almandoz, Josser E Delgado, Fraser, Justin F, Frei, Donald, Gandhi, Chirag D, Heck, Don V, Hetts, Steven W, Hussain, M Shazam, Kelly, Michael, Klucznik, Richard, Lee, Seon-Kyu, Leslie-Mawzi, Thabele, Meyers, Philip M, Prestigiacomo, Charles J, Pride, G Lee, Patsalides, Athos, Starke, Robert M, Sunenshine, Peter, Rasmussen, Peter A, and Jayaraman, Mahesh V

Published
2017
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29. Infarct in a New Territory After Treatment Administration in the ESCAPE Randomized Controlled Trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times)

Author

Ganesh, Aravind, Al-Ajlan, Fahad S., Sabiq, Farahna, Assis, Zarina, Rempel, Jeremy L., Butcher, Kenneth, Thornton, John, Kelly, Peter, Roy, Daniel, Poppe, Alexandre Y., Jovin, Tudor G., Devlin, Thomas, Baxter, Blaise W., Krings, Timo, Casaubon, Leanne K., Frei, Donald F., Choe, Hana, Tampieri, Donatella, Teitelbaum, Jeanne, Lum, Cheemun, Mandzia, Jennifer, Phillips, Stephen J., Bang, Oh Young, Almekhlafi, Mohammed A., Coutts, Shelagh B., Barber, Philip A., Sajobi, Tolulope, Demchuk, Andrew M., Eesa, Muneer, Hill, Michael D., Goyal, Mayank, and Menon, Bijoy K.

Published
2016
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30. sj-docx-1-wso-10.1177_17474930221077164 ��� Supplemental material for Endovascular treatment for acute basilar artery occlusion: A multicenter randomized controlled trial (ATTENTION)

Author

Tao, Chunrong, Li, Rui, Zhu, Yuyou, Qun, Sen, Xu, Pengfei, Wang, Li, Zhang, Chao, Liu, Tianlong, Song, Jianlong, Sun, Wen, Wang, Guoping, Baxter, Blaise, Qureshi, Adnan, Liu, Xinfeng, Nogueira, Raul G, and Hu, Wei

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930221077164 for Endovascular treatment for acute basilar artery occlusion: A multicenter randomized controlled trial (ATTENTION) by Chunrong Tao, Rui Li, Yuyou Zhu, Sen Qun, Pengfei Xu, Li Wang, Chao Zhang, Tianlong Liu, Jianlong Song, Wen Sun, Guoping Wang, Blaise Baxter, Adnan Qureshi, Xinfeng Liu, Raul G Nogueira and Wei Hu in International Journal of Stroke

Published
2022
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31. Endovascular treatment for acute basilar artery occlusion: A multicenter randomized controlled trial (ATTENTION)

Author

Tao, Chunrong, primary, Li, Rui, additional, Zhu, Yuyou, additional, Qun, Sen, additional, Xu, Pengfei, additional, Wang, Li, additional, Zhang, Chao, additional, Liu, Tianlong, additional, Song, Jianlong, additional, Sun, Wen, additional, Wang, Guoping, additional, Baxter, Blaise, additional, Qureshi, Adnan, additional, Liu, Xinfeng, additional, Nogueira, Raul G, additional, and Hu, Wei, additional

Published
2022
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32. Aspiration Thrombectomy After Intravenous Alteplase Versus Intravenous Alteplase Alone

Author

Mocco, J, Zaidat, Osama O., von Kummer, Rüdiger, Yoo, Albert J., Gupta, Rishi, Lopes, Demetrius, Frei, Don, Shownkeen, Harish, Budzik, Ron, Ajani, Zahra A., Grossman, Aaron, Altschul, Dorethea, McDougall, Cameron, Blake, Lindsey, Fitzsimmons, Brian-Fred, Yavagal, Dileep, Terry, John, Farkas, Jeffrey, Lee, Seon Kyu, Baxter, Blaise, Wiesmann, Martin, Knauth, Michael, Heck, Donald, Hussain, Syed, Chiu, David, Alexander, Michael J., Malisch, Timothy, Kirmani, Jawad, Miskolczi, Laszlo, and Khatri, Pooja

Published
2016
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33. Intra-Arterial Therapy and Post-Treatment Infarct Volumes: Insights From the ESCAPE Randomized Controlled Trial

Author

Al-Ajlan, Fahad S., Goyal, Mayank, Demchuk, Andrew M., Minhas, Priyanka, Sabiq, Farahna, Assis, Zarina, Willinsky, Robert, Montanera, Walter J., Rempel, Jeremy L., Shuaib, Ashfaq, Thornton, John, Williams, David, Roy, Daniel, Poppe, Alexandre Y., Jovin, Tudor G., Sapkota, Biggya L., Baxter, Blaise W., Krings, Timo, Silver, Frank L., Frei, Donald F., Fanale, Christopher, Tampieri, Donatella, Teitelbaum, Jeanne, Lum, Cheemun, Dowlatshahi, Dar, Shankar, Jai J., Barber, Philip A., Hill, Michael D., and Menon, Bijoy K.

Published
2016
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34. Clinical and Procedural Predictors of Outcomes From the Endovascular Treatment of Posterior Circulation Strokes

Author

Mokin, Maxim, Sonig, Ashish, Sivakanthan, Sananthan, Ren, Zeguang, Elijovich, Lucas, Arthur, Adam, Goyal, Nitin, Kan, Peter, Duckworth, Edward, Veznedaroglu, Erol, Binning, Mandy J., Liebman, Kenneth M., Rao, Vikas, Turner, Raymond D., IV, Turk, Aquilla S., Baxter, Blaise W., Dabus, Guilherme, Linfante, Italo, Snyder, Kenneth V., Levy, Elad I., and Siddiqui, Adnan H.

Published
2016
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35. Ischemic core and hypoperfusion volumes predict infarct size in SWIFT PRIME

Author

Albers, Gregory W., Goyal, Mayank, Jahan, Reza, Bonafe, Alain, Diener, Hans-Christoph, Levy, Elad I., Pereira, Vitor M., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., Baxter, Blaise W., Devlin, Thomas G., Lopes, Demetrius K., Reddy, Vivek K., de Rochemont, Richard du Mesnil, Singer, Oliver C., Bammer, Roland, and Saver, Jeffrey L.

Published
2016
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36. Abstract 1122‐000176: Incidence and Predictors of Delayed Functional Independence in the TREVO Retriever Registry

Author

Desai, Shashvat M, primary, Jadhav, Ashutosh P, additional, Gupta, Rishi, additional, Baxter, Blaise W, additional, Bartolini, Bruno, additional, Krajina, Antonin, additional, English, Joey, additional, Nogueira, Raul G, additional, Liebeskind, David S, additional, Veznedaroglu, Erol, additional, and Budzik, Ronald F, additional

Published
2021
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37. Intravenous alteplase has different effects on the efficacy of aspiration and stent retriever thrombectomy: analysis of the COMPASS trial

Author

Mokin, Maxim, primary, Waqas, Muhammad, additional, Fifi, Johanna T, additional, De Leacy, Reade, additional, Fiorella, David, additional, Levy, Elad I, additional, Snyder, Kenneth, additional, Hanel, Ricardo A, additional, Woodward, Keith, additional, Chaudry, Imran, additional, Rai, Ansaar T, additional, Frei, Donald, additional, Delgado Almandoz, Josser E, additional, Kelly, Michael, additional, Arthur, Adam S, additional, Baxter, Blaise W, additional, English, Joey, additional, Linfante, Italo, additional, Fargen, Kyle M, additional, Turk, Aquilla, additional, Mocco, J, additional, and Siddiqui, Adnan H, additional

Published
2021
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38. Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke

Author

Saver, Jeffrey L., Goyal, Mayank, Bonafe, Alain, Diener, Hans-Christoph, Levy, Elad I., Pereira, Vitor M., Albers, Gregory W., Cognard, Christophe, Cohen, David J., Hacke, Werner, Jansen, Olav, Jovin, Tudor G., Mattle, Heinrich P., Nogueira, Raul G., Siddiqui, Adnan H., Yavagal, Dileep R., Baxter, Blaise W., Devlin, Thomas G., Lopes, Demetrius K., Reddy, Vivek K., de Rochemont, Richard du Mesnil, Singer, Oliver C., and Jahan, Reza

Published
2015
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40. Embolectomy for stroke with emergent large vessel occlusion (ELVO): report of the Standards and Guidelines Committee of the Society of NeuroInterventional Surgery

Author

Jayaraman, Mahesh V, Hussain, M Shazam, Abruzzo, Todd, Albani, Barbara, Albuquerque, Felipe C, Alexander, Michael J, Ansari, Sameer A, Arthur, Adam S, Baxter, Blaise, Bulsara, Ketan R, Chen, Michael, Delgado-Almandoz, Josser A, Fraser, Justin F, Heck, Don V, Hetts, Steven W, Kelly, Michael, Lee, Seon-Kyu, Leslie-Mawzi, Thabele, McTaggart, Ryan A, Meyers, Philip M, Prestigiacomo, Charles, Pride, G Lee, Patsalides, Athos, Starke, Robert M, Tarr, Robert W, Frei, Don, and Rasmussen, Peter

Published
2015
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41. Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

Author

Goyal, Mayank, Demchuk, Andrew M., Menon, Bijoy K., Eesa, Muneer, Rempel, Jeremy L., Thornton, John, Roy, Daniel, Jovin, Tudor G., Willinsky, Robert A., Sapkota, Biggya L., Dowlatshahi, Dar, Frei, Donald F., Kamal, Noreen R., Montanera, Walter J., Poppe, Alexandre Y., Ryckborst, Karla J., Silver, Frank L., Shuaib, Ashfaq, Tampieri, Donatella, Williams, David, Bang, Oh Young, Baxter, Blaise W., Burns, Paul A., Choe, Hana, Heo, Ji-Hoe, Holmstedt, Christine A., Jankowitz, Brian, Kelly, Michael, Linares, Guillermo, Mandzia, Jennifer L., Shankar, Jai, Sohn, Sung-Il, Swartz, Richard H., Barber, Philip A., Coutts, Shelagh B., Smith, Eric E., Morrish, William F., Weill, Alain, Subramaniam, Suresh, Mitha, Alim P., Wong, John H., Lowerison, Mark W., Sajobi, Tolulope T., and Hill, Michael D.

Published
2015
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42. Healthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke

Author

Almekhlafi, Mohammed, Goyal, Mayank, Dippel, Diederik, Majoie, Charles, Campbell, Bruce, Muir, Keith, Demchuk, Andrew, Bracard, Serge, Guillemin, Francis, Jovin, Tudor, Mitchell, Peter, White, Philip, Hill, Michael, Brown, Scott, Saver, Jeffrey, Berkhemer, Olvert, Fransen, Puck, Beumer, Debbie, Van Den Berg, Lucie, Lingsma, Hester, Yoo, Albert, Schonewille, Wouter, Vos, Jan, Nederkoorn, Paul, Wermer, Marieke, Van Walderveen, Marianne, Staals, Julie, Hofmeijer, Jeannette, Van Oostayen, Jacques, Lycklama À Nijeholt, Geert, Boiten, Jelis, Brouwer, Patrick, Emmer, Bart, De Bruijn, Sebastiaan, Van Dijk, Lukas, Kappelle, L, Lo, Rob, Van Dijk, Ewoud, de Vries, Joost, De Kort, Paul, Van Rooij, Willem, Van Den Berg, Jan, Van Hasselt, Boudewijn, Aerden, Leo, Dallinga, René, Visser, Marieke, Bot, Joseph, Vroomen, Patrick, Eshghi, Omid, Schreuder, Tobien, Heijboer, Roel, Keizer, Koos, Tielbeek, Alexander, Den Hertog, Heleen, Gerrits, Dick, Van Den Berg-Vos, Renske, Karas, Giorgos, Steyerberg, Ewout, Flach, H, Marquering, Henk, Sprengers, Marieke, Jenniskens, Sjoerd, Beenen, Ludo, Van Den Berg, René, Koudstaal, Peter, Van Zwam, Wim, Roos, Yvo, van der Lugt, Aad, Van Oostenbrugge, Robert, Menon, Bijoy, Eesa, Muneer, Rempel, Jeremy, Thornton, John, Roy, Daniel, Willinsky, Robert, Sapkota, Biggya, Dowlatshahi, Dar, Frei, Donald, Kamal, Noreen, Montanera, Walter, Poppe, Alexandre, Ryckborst, Karla, Silver, Frank, Shuaib, Ashfaq, Tampieri, Donatella, Williams, David, Bang, Oh, Baxter, Blaise, Burns, Paul, Choe, Hana, Heo, Ji-Hoe, Holmstedt, Christine, Jankowitz, Brian, KELLY, Michael, Linares, Guillermo, Mandzia, Jennifer, Shankar, Jai, Sohn, Sung-Il, Swartz, Richard, Coutts, Shelagh, Smith, Eric, Morrish, William, Weill, Alain, Subramaniam, Suresh, Mitha, Alim, Wong, John, Lowerison, Mark, Sajobi, Tolulope, Bonafe, Alain, Diener, Hans, Levy, Elad, Pereira, Vitor, Albers, Gregory, Cognard, Christophe, Cohen, David, Hacke, Werner, Jansen, Olav, Mattle, Heinrich, Nogueira, Raul, Siddiqui, Adnan, Yavagal, Dileep, Devlin, Thomas, Lopes, Demetrius, Reddy, Vivek, du Mesnil de Rochemont, Richard, Singer, Oliver, Jahan, Reza, Kleinig, Timothy, Dewey, Helen, Churilov, Leonid, Yassi, Nawaf, Yan, Bernard, Dowling, Richard, Parsons, Mark, Oxley, Thomas, Wu, Teddy, Brooks, Mark, Simpson, Marion, Miteff, Ferdinand, Levi, Christopher, Krause, Martin, Harrington, Timothy, Faulder, Kenneth, Steinfort, Brendan, Priglinger, Miriam, Ang, Timothy, Scroop, Rebecca, Barber, Philip, McGuinness, Ben, Wijeratne, Tissa, Phan, Thanh, Chong, Winston, Chandra, Ronil, Bladin, Christopher, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Ma, Henry, Desmond, Patricia, Donnan, Geoffrey, Davis, Stephen, Chamorro, Angel, Cobo, Erik, De Miquel, María, Molina, Carlos, Rovira, Alex, San Román, Luis, Serena, Joaquín, Abilleira, Sonia, Ribó, Marc, Millán, Mònica, Urra, Xabier, Cardona, Pere, López-Cancio, Elena, Tomasello, Alejandro, Castaño, Carlos, Blasco, Jordi, Aja, Lucía, Dorado, Laura, Quesada, Helena, Rubiera, Marta, Hernandez-Pérez, María, von Kummer, Rüdiger, Gallofré, Miquel, Dávalos, Antoni, Ford, Gary, Messow, Claudia-Martina, Ford, Ian, Murray, Alicia, Clifton, Andrew, Brown, Martin, Madigan, Jeremy, Lenthall, Rob, Robertson, Fergus, Dixit, Anand, Cloud, Geoffrey, Wardlaw, Joanna, Freeman, Janet, Ducrocq, Xavier, Mas, Jean, Soudant, Marc, Oppenheim, Catherine, Moulin, Thierry, University of Calgary, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Radiology and Nuclear Medicine [Amsterdam], VU University Medical Center [Amsterdam], University of Melbourne, University of Glasgow, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), The Royal Melbourne Hospital, Newcastle University [Newcastle], Altair Development, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), and University of California-University of California

Subjects
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known. OBJECTIVE To assess the lifetime outcomes associated with speed of endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion (LVO). DATA SOURCES PubMed was searched for randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in patients with anterior circulation LVO within 12 hours of last known well time, and for which a peer-reviewed, complete primary results article was published by August 1, 2020.

Published
2021

43. Intravenous alteplase has different effects on the efficacy of aspiration and stent retriever thrombectomy: analysis of the COMPASS trial.

Author

Mokin, Maxim, Waqas, Muhammad, Fifi, Johanna T., de De Leacy, Rea, Fiorella, David, Levy, Elad I., Snyder, Kenneth, Hanel, Ricardo A., Woodward, Keith, Chaudry, Imran, Rai, Ansaar T., Frei, Donald, Delgado Almandoz, Josser E., Kelly, Michael, Arthur, Adam S., Baxter, Blaise W., English, Joey, Linfante, Italo, Fargen, Kyle M., and Turk, Aquilla

Subjects
ARTERIAL occlusions, STATISTICS, INTRAVENOUS therapy, RESPIRATORY aspiration, MULTIVARIATE analysis, CEREBRAL infarction, SURGICAL stents, DECISION support systems, TREATMENT effectiveness, THROMBECTOMY, DESCRIPTIVE statistics, DATA analysis, DATA analysis software, TISSUE plasminogen activator
Abstract

Background There is conflicting evidence on the utility of intravenous (IV) alteplase in patients with emergent large vessel occlusion (ELVO) treated with mechanical thrombectomy (MT). Methods This was a post hoc analysis of the COMPASS: a trial of aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion. We compared clinical, procedural and angiographic outcomes of patients with and without prior IV alteplase administration. Results In the COMPASS trial, 235 patients had presented to the hospital within the first 4 hours of stroke symptom onset and were eligible for analysis. On univariate analysis, administration of IV alteplase prior to MT was found to be significantly associated with favorable outcomes (modified Rankin scale (mRS) 0--2 at 3 months; 55.6% vs 40.0% in the MT-only group, P=0.037). However, on multivariate analysis, only baseline (pre-stroke) mRS, admission National Institutes of Health Stroke Scale (NIHSS) score and age were identified as independent predictors of favorable outcomes at 3 months. We found higher final thrombolysis in cerebral infarction (TICI) 2b/3 rates in patients without the use of alteplase prior to the aspiration first approach (100.0% vs 87.9% in IV altepase +aspiration first MT, P=0.03). In the stent retriever first group, final TICI 2b/3 rates were identical in patients with and without IV alteplase administration (87.5% and 87.5%, P=1.0). Conclusions Prior administration of IV alteplase may adversely affect the efficacy of aspiration, but does not seem to influence the stent retriever first approach to MT in patients with anterior circulation ELVO. [ABSTRACT FROM AUTHOR]

Published
2022
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44. sj-pdf-2-wso-10.1177_17474930211005740 - Supplemental material for Clinical effectiveness of endovascular stroke treatment in the early and extended time windows

Author

Nogueira, Raul G, Haussen, Diogo C, Liebeskind, David S, Jovin, Tudor G, Rishi Gupta, Saver, Jeffrey L, Jadhav, Ashutosh P, Budzik, Ronald F, Baxter, Blaise, Krajina, Antonin, Bonafe, Alain, Malek, Ali, Narata, Ana Paula, Mohammaden, Mahmoud H, Yanchang Zhang, Morgan, Patricia, Minyi Ji, Bartolini, Bruno, English, Joey, Albers, Gregory W, Mlynash, Michael, Lansberg, Maarten G, Frankel, Michael R, Vitor M Pereira, and Veznedaroglu, Erol

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-2-wso-10.1177_17474930211005740 for Clinical effectiveness of endovascular stroke treatment in the early and extended time windows by Raul G Nogueira, Diogo C Haussen, David S Liebeskind, Tudor G Jovin, Rishi Gupta, Jeffrey L Saver, Ashutosh P Jadhav, Ronald F Budzik, Blaise Baxter, Antonin Krajina, Alain Bonafe, Ali Malek, Ana Paula Narata, Mahmoud H Mohammaden, Yanchang Zhang, Patricia Morgan, Minyi Ji, Bruno Bartolini, Joey English, Gregory W Albers, Michael Mlynash, Maarten G Lansberg, Michael R Frankel, Vitor M Pereira, Erol Veznedaroglu and for the Trevo Registry, SWIFT Prime, DEFUSE 3 and DAWN Trial Investigators in International Journal of Stroke

Published
2021
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45. sj-pdf-1-wso-10.1177_17474930211005740 - Supplemental material for Clinical effectiveness of endovascular stroke treatment in the early and extended time windows

Author

Nogueira, Raul G, Haussen, Diogo C, Liebeskind, David S, Jovin, Tudor G, Rishi Gupta, Saver, Jeffrey L, Jadhav, Ashutosh P, Budzik, Ronald F, Baxter, Blaise, Krajina, Antonin, Bonafe, Alain, Malek, Ali, Narata, Ana Paula, Mohammaden, Mahmoud H, Yanchang Zhang, Morgan, Patricia, Minyi Ji, Bartolini, Bruno, English, Joey, Albers, Gregory W, Mlynash, Michael, Lansberg, Maarten G, Frankel, Michael R, Vitor M Pereira, and Veznedaroglu, Erol

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-wso-10.1177_17474930211005740 for Clinical effectiveness of endovascular stroke treatment in the early and extended time windows by Raul G Nogueira, Diogo C Haussen, David S Liebeskind, Tudor G Jovin, Rishi Gupta, Jeffrey L Saver, Ashutosh P Jadhav, Ronald F Budzik, Blaise Baxter, Antonin Krajina, Alain Bonafe, Ali Malek, Ana Paula Narata, Mahmoud H Mohammaden, Yanchang Zhang, Patricia Morgan, Minyi Ji, Bruno Bartolini, Joey English, Gregory W Albers, Michael Mlynash, Maarten G Lansberg, Michael R Frankel, Vitor M Pereira, Erol Veznedaroglu and for the Trevo Registry, SWIFT Prime, DEFUSE 3 and DAWN Trial Investigators in International Journal of Stroke

Published
2021
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46. sj-pdf-1-wso-10.1177_17474930211006304 - Supplemental material for Influence of time to endovascular stroke treatment on outcomes in the early versus extended window paradigms

Author

Nogueira, Raul G, Jovin, Tudor G, Haussen, Diogo C, Rishi Gupta, Ashutov Jadhav, Budzik, Ronald F, Baxter, Blaise, Krajina, Antonin, Bonafe, Alain, Malek, Ali, Narata, Ana Paula, Shields, Ryan, Yanchang Zhang, Morgan, Patricia, Bartolini, Bruno, English, Joey, Mohammaden, Mahmoud, Frankel, Michael R, Liebeskind, David S, and Veznedaroglu, Erol

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-wso-10.1177_17474930211006304 for Influence of time to endovascular stroke treatment on outcomes in the early versus extended window paradigms by Raul G Nogueira, Tudor G Jovin, Diogo C Haussen, Rishi Gupta, Ashutov Jadhav, Ronald F Budzik, Blaise Baxter, Antonin Krajina, Alain Bonafe, Ali Malek, Ana Paula Narata, Ryan Shields, Yanchang Zhang, Patricia Morgan, Bruno Bartolini, Joey English, Mahmoud Mohammaden, Michael R Frankel, David S Liebeskind, Erol Veznedaroglu and for the Trevo Registry and DAWN Trial Investigators in International Journal of Stroke

Published
2021
Full Text
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49. Which Acute Ischemic Stroke Patients Are Fast Progressors?

Author

Ospel, Johanna M., primary, Hill, Michael D., additional, Kappelhof, Manon, additional, Demchuk, Andrew M., additional, Menon, Bijoy K., additional, Mayank, Arnuv, additional, Dowlatshahi, Dar, additional, Frei, Don, additional, Rempel, Jeremy L., additional, Baxter, Blaise, additional, and Goyal, Mayank, additional

Published
2021
Full Text
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50. Abstract P467: Clinical Effectiveness of Endovascular Stroke Treatment in the Early and Extended Time Windows

Author

Nogueira, Raul, primary, Haussen, Diogo C, additional, Liebeskind, David S, additional, Jovin, Tudor G, additional, Gupta, Rishi, additional, Saver, Jeffrey L, additional, Jadhav, Ashutosh, additional, Budzik, Ron, additional, Baxter, Blaise W, additional, Krajina, Antonin, additional, Bonafe, Alain, additional, Malek, Ali R, additional, Ana Paula, Narata, additional, Mohammaden, Mahmoud, additional, Zhang, Yanchang, additional, Morgan, Patricia, additional, Ji, Minyi, additional, Bartolini, Bruno, additional, English, Joey, additional, Albers, Gregory, additional, Mlynash, Michael, additional, Lansberg, Maarten G, additional, Michael, Frankel, additional, Pereira, Vitor, additional, and Veznedaroglu, Erol, additional

Published
2021
Full Text
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