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2. CONTRIBUTORS

Author

Abahuje, Egide, primary, Abrahim, Orit, additional, Adetifa, Ifedayo M.O., additional, Ajjampur, Sitara S.R., additional, Alexander, Suceena, additional, PhD, Chiara Altare,, additional, Alves, Fabiana, additional, Andrianaivoarimanana, Voahangy, additional, Angelakis, Emmanouil, additional, Aronson, Jeffrey K., additional, Atukorala, Inoshi G., additional, Baily, Guy, additional, Baker, Stephen, additional, Barrett, Alan D.T., additional, Basnyat, Buddha, additional, Bastawrous, Andrew, additional, Bates, Imelda, additional, Bausch, Daniel G., additional, Baxter, Cheryl, additional, Beare, Nicholas A.V., additional, Beeching, Nick J., additional, Bekker, Linda-Gail, additional, Berlin, Anita, additional, FRS, Zulfiqar A. Bhutta, additional, Bloom, David E., additional, Blumberg, Lucille, additional, Boelaert, Marleen, additional, Brett-Major, David, additional, Brooker, Simon J., additional, Brouwer, Matthijs C., additional, Brunetti, Enrico, additional, Bull, Susan, additional, Bundy, Donald A.P., additional, Burri, Christian, additional, Bustinduy, Amaya L., additional, Caillet, Céline, additional, Chai, Jong Yil, additional, Chang, Thashi, additional, Chappuis, François, additional, Chibi, Buyisile, additional, Chiodini, Peter L., additional, Chowdhury, Rajiv, additional, Chowdhury, Sudipta Dhar, additional, Clemens, John D., additional, Cooke, Graham S., additional, Cotton, Mark F., additional, Currie, Bart J., additional, Cusack, Tomas-Paul, additional, Dance, David A.B., additional, Davis, Emily H., additional, Day, Nicholas P.J., additional, Deen, Jacqueline, additional, Dondorp, Arjen M., additional, Dünser, Martin W., additional, Eitzen, Edward, additional, Chebib, Hassan El, additional, Enria, Delia, additional, Faust, Christina, additional, Fekadu, Abebaw, additional, Fink, Günther, additional, Fischer, Peter U., additional, Fletcher, Tom, additional, Franco-Paredes, Carlos, additional, French, Neil, additional, Frumkin, Howard, additional, Garcia, Hector H., additional, Gerada, Alessandro, additional, Glass, Roger I., additional, Gordon, Stephen B., additional, Gottstein, Bruno, additional, Goyal, Alpesh, additional, Grey, Jonathan, additional, Gupta, Yashdeep, additional, Haines, Andy, additional, Hampson, Katie, additional, Hanlon, Charlotte, additional, Harrison, Mark, additional, Haswell, Melissa R., additional, Hawkesworth, Sophie, additional, Hay, Roderick J., additional, Heckmann, Jeannine M., additional, Heimesaat, Markus M., additional, Henao-Martínez, Andrés F., additional, Hien, Tran Tinh, additional, Hoerauf, Achim, additional, Irfan, Omar, additional, PhD, Euzebiusz Jamrozik, additional, Jobe, Modou, additional, John, George T., additional, Jones, Nick K., additional, Jones, Malcolm K., additional, Junghanss, Thomas, additional, Kaewkes, Sasithorn, additional, Karim, Quarraisha Abdool, additional, Keiser, Jennifer, additional, Kelly, Paul, additional, Khan, Amira M., additional, King, Charles H., additional, Kishore, Sandeep P., additional, Lang, Trudie, additional, Le, Thuy, additional, Liesenfeld, Oliver, additional, Lockwood, Diana N.J., additional, Mabey, David C.W., additional, Madkour, M. Monir, additional, Manesh, Abi, additional, Masekela, Refiloe, additional, Mäser, Pascal, additional, Mayaud, Philippe, additional, Mbanya, Dora, additional, McCarthy, James S., additional, McCartney, Daniel J., additional, McGready, Rose, additional, McKee, Martin, additional, Mc, Namara, Paul S., additional, Meara, John G., additional, Meintjes, Graeme, additional, Merson, Laura, additional, Mola, Glen, additional, Morassutti, Alessandra L., additional, Morris-Jones, Rachael, additional, Mortimer, Kevin J., additional, Muliyil, Divya Elizabeth, additional, Mumcuoglu, Kosta Y., additional, Munoz, Flor M., additional, Murphy, Adrianna, additional, Mutabingwa, Theonest, additional, Nawa, Yukifumi, additional, Newton, Paul N., additional, Nightingale, Sam, additional, Nokes, D. James, additional, Nosten, François H., additional, O’Hea, Jennifer, additional, Olliaro, Piero, additional, Ong, Jason J., additional, Oommen, Anu Mary, additional, Parashar, Umesh D., additional, Paris, Daniel H., additional, Parker, Michael, additional, Pluschke, Gerd, additional, Preidis, Geoffrey A., additional, Prentice, Andrew M., additional, Quail, Geoffrey, additional, Quinn, Thomas C., additional, Rabie, Helena, additional, Rajashekharaiah, Harsha, additional, Rajerison, Minoarisoa, additional, Ranganathan, Kannan, additional, Raoult, Didier, additional, Rassi,, Anis, additional, Ravi, Vasanthapuram, additional, Reddy, K. Srinath, additional, Rees, Claire, additional, Reynolds, Steven J., additional, Richter, Joachim, additional, Rijken, Marcus J., additional, Riviello, Robert, additional, Robinson, Janet, additional, Salazar, Juan C., additional, Schultz, Marcus J., additional, Schwarz, Dan, additional, Sendagire, Ibrahim, additional, Sharma, Savitri, additional, Shawon, Shajedur Rahman, additional, Singh, Bhagteshwar, additional, Sithithaworn, Paiboon, additional, Siwila, Joyce, additional, Solomon, Tom, additional, Spiegel, Paul, additional, Sridhar, Devi, additional, Sripa, Banchob, additional, Srour, M. Leila, additional, Stojković, Marija, additional, Strader, Christopher, additional, Suárez, Jose A., additional, Sundar, Shyam, additional, Tamarozzi, Francesca, additional, Tandon, Nikhil, additional, Tate, Jacqueline E., additional, Thachil, Jecko, additional, Thomson, Madeleine C., additional, Thwaites, Guy, additional, Thwaites, C. Louise, additional, van Daalen, Kim R., additional, Beek, Diederik van de, additional, van Doorn, H. Rogier, additional, Vega-Lopez, Francisco, additional, von Seidlein, MD, PhD, Lorenz, additional, Wakeham, Katie, additional, Walker, Stephen L., additional, Wallace, Ryan M., additional, Ward, Honorine, additional, Warrell, David A., additional, Weber, Tim Frederik, additional, Weil, Gary J., additional, White, Nicholas J., additional, White, MB Ch, B, Graham B., additional, Wong, Vanessa, additional, Wood, Robin, additional, Wood, Georgina, additional, Wyllie, Sarah, additional, Yacoub, Sophie, additional, Yen, Lam Minh, additional, Young, Paul R., additional, and Zafren, Ken, additional

Published
2024
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6. Dispersal patterns and influence of air travel during the global expansion of SARS-CoV-2 variants of concern

Author

Tegally, Houriiyah, Wilkinson, Eduan, Tsui, Joseph L.- H., Moir, Monika, Martin, Darren, Brito, Anderson Fernandes, Giovanetti, Marta, Khan, Kamran, Huber, Carmen, Bogoch, Isaac I., San, James Emmanuel, Poongavanan, Jenicca, Xavier, Joicymara S., Candido, Darlan da S., Romero, Filipe, Baxter, Cheryl, Pybus, Oliver G., Lessells, Richard J., Faria, Nuno R., Kraemer, Moritz U.G., and de Oliveira, Tulio

Published
2023
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7. Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa

Author

Tegally, Houriiyah, Moir, Monika, Everatt, Josie, Giovanetti, Marta, Scheepers, Cathrine, Wilkinson, Eduan, Subramoney, Kathleen, Makatini, Zinhle, Moyo, Sikhulile, Amoako, Daniel G., Baxter, Cheryl, Althaus, Christian L., Anyaneji, Ugochukwu J., Kekana, Dikeledi, Viana, Raquel, Giandhari, Jennifer, Lessells, Richard J., Maponga, Tongai, Maruapula, Dorcas, Choga, Wonderful, Matshaba, Mogomotsi, Mbulawa, Mpaphi B., Msomi, Nokukhanya, Naidoo, Yeshnee, Pillay, Sureshnee, Sanko, Tomasz Janusz, San, James E., Scott, Lesley, Singh, Lavanya, Magini, Nonkululeko A., Smith-Lawrence, Pamela, Stevens, Wendy, Dor, Graeme, Tshiabuila, Derek, Wolter, Nicole, Preiser, Wolfgang, Treurnicht, Florette K., Venter, Marietjie, Chiloane, Georginah, McIntyre, Caitlyn, O’Toole, Aine, Ruis, Christopher, Peacock, Thomas P., Roemer, Cornelius, Kosakovsky Pond, Sergei L., Williamson, Carolyn, Pybus, Oliver G., Bhiman, Jinal N., Glass, Allison, Martin, Darren P., Jackson, Ben, Rambaut, Andrew, Laguda-Akingba, Oluwakemi, Gaseitsiwe, Simani, von Gottberg, Anne, and de Oliveira, Tulio

Published
2022
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11. An Oxford Nanopore Technology-Based Hepatitis B Virus Sequencing Protocol Suitable For Genomic Surveillance Within Clinical Diagnostic Settings.

Author

Tshiabuila, Derek, primary, Choga, Wonderful, additional, San, James Emmanuel, additional, Maponga, Tongai, additional, Preiser, Wolfgang, additional, van Zyl, Gert, additional, Moir, Monika, additional, van Wyk, Stephanie, additional, Giandhari, Jennifer, additional, Pillay, Sureshnee, additional, Anyaneji, Uguchukwu Jacob, additional, Lessells, Richard, additional, Naidoo, Yeshnee, additional, Sanko, Tomasz Janusz, additional, Wilkinson, Eduan, additional, Tegally, Houriiyah, additional, Baxter, Cheryl, additional, Martin, Darren, additional, and de Oliveira, Tulio, additional

Published
2024
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15. An emerging clade of Chikungunya West African genotype discovered in real-time during 2023 outbreak in Senegal

Author

Padane, Abdou, primary, Tegally, Houriiyah, additional, Ramphal, Yajna, additional, Ndiaye, Seyni, additional, Sarr, Mariema, additional, Diop, Mame Matar, additional, Diedhiou, Cyrille Kouligueul, additional, Mboup, Aminata, additional, Diouf, Ndeye Dieyna, additional, Souare, Abdoulaye, additional, Diagne, Ndeye Diabou, additional, Aza-Gnandji, Marilyne, additional, Dabo, Ndeye Astou, additional, Dia, Yacine Amet, additional, Diaw, Ndeye Aminata, additional, Leye, Nafissatou, additional, Diaw, Papa Alassane, additional, Ambroise, Ambroise, additional, Cisse, Badara, additional, Diallo, Abdoulaye Samba, additional, Diop, Ousmane, additional, Diallo, Abdoul Aziz, additional, Ndoye, Souado, additional, Sanko, Tomasz J, additional, Baxter, Cheryl, additional, Wilkinson, Eduan, additional, James, San Emmanuel, additional, Tshiabuila, Derek, additional, Naidoo, Yeshnee, additional, Pillay, Sureshnee, additional, Lessells, Richard, additional, Cisse, Khady, additional, Leye, Ababacar, additional, Mbaye, Ababacar, additional, Kania, Dramane, additional, Traore, Isidore, additional, Kagone, Sampawende Therese, additional, Tinto, Bachirou, additional, Ouedraogo, Abdoul-Salam, additional, Lourenco, Jose, additional, Giovanetti, Marta, additional, Giandhari, Jennifer, additional, de Oliveira, Tulio, additional, and Mboup, Souleymane, additional

Published
2023
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17. Insights into SARS‐CoV‐2 in Angola during the COVID‐19 peak: Molecular epidemiology and genome surveillance

Author

Francisco, Ngiambudulu M., primary, van Wyk, Stephanie, additional, Moir, Monika, additional, San, James Emmanuel, additional, Sebastião, Cruz S., additional, Tegally, Houriiyah, additional, Xavier, Joicymara, additional, Maharaj, Akhil, additional, Neto, Zoraima, additional, Afonso, Pedro, additional, Jandondo, Domingos, additional, Paixão, Joana, additional, Miranda, Julio, additional, David, Kumbelembe, additional, Inglês, Luzia, additional, Pereira, Amilton, additional, Paulo, Agostinho, additional, Carralero, Raisa Rivas, additional, Freitas, Helga Reis, additional, Mufinda, Franco, additional, Lutucuta, Silvia, additional, Ghafari, Mahan, additional, Giovanetti, Marta, additional, Giandhari, Jennifer, additional, Pillay, Sureshnee, additional, Naidoo, Yeshnee, additional, Singh, Lavanya, additional, Tshiabuila, Derek, additional, Martin, Darren Patrick, additional, Chabuka, Lucious, additional, Choga, Wonderful, additional, Wanjohi, Dorcas, additional, Mwangi, Sarah, additional, Pillay, Yusasha, additional, Kebede, Yenew, additional, Shumba, Edwin, additional, Ondoa, Pascale, additional, Baxter, Cheryl, additional, Wilkinson, Eduan, additional, Tessema, Sofonias Kifle, additional, Katzourakis, Aris, additional, Lessells, Richard, additional, de Oliveira, Tulio, additional, and Morais, Joana, additional

Published
2023
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22. Integrated provision of topical pre-exposure prophylaxis in routine family planning services in South Africa: a non-inferiority randomized controlled trial

Author

Mansoor, Leila E., Yende-Zuma, Nonhlanhla, Baxter, Cheryl, Mngadi, Kathryn T., Dawood, Halima, Gengiah, Tanuja N., Samsunder, Natasha, Schwartz, Jill L., Doncel, Gustavo F., and Karim, Quarraisha Abdool

Subjects
PREP Inc. -- Product development, Clinical trials, Prophylaxis, Emtricitabine -- Product development, Health care industry -- Product development, Family planning services -- Product development, Software industry -- Product development, Tenofovir, Sexually transmitted disease prevention -- Product development, Family planning, Health care industry, Health
Abstract

Introduction: Tenofovir-containing oral pre-exposure prophylaxis (PrEP) is recommended for those at substantial risk as part of combination HIV prevention. However, there are limited data, beyond clinical trial settings, to guide the introduction of PrEP in healthcare services with adequate levels of adherence. Since young women in Africa are at high risk of HIV and likely to utilize family planning (FP) services, the feasibility, acceptability and effectiveness of integrating topical PrEP provision into routine FP services was assessed. Methods: This two-arm, randomized controlled, non-inferiority open-label extension trial was undertaken in urban and rura KwaZulu-Natal, South Africa. HIV-negative eligible women (n = 372) from the parent trial (Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004) were randomized to receive tenofovir gel either through intervention (FP clinics, n = 189) or control clinics (CAPRISA research clinics, n = 183). Non-inferiority was predefined as gel use in the intervention clinics would be no more than 20% lower than in the control clinics. Adherence, retention and HIV incidence rates were assessed. Results: Women were enrolled between November 2012 and October 2014, and followed up for 682.3 women-years (mean = 22 months). Baseline characteristics of women in intervention and control clinics were comparable and retention rates were 92.1% and 92.3% respectively. Women in intervention clinics and control clinics returned on average 5.2 (95% confidence interval (CI): 4.7 to 5.7) and 5.7 (CI: 5.2 to 6.2) used gel applicators per month respectively, with a mean difference of -0.47 (CI: -1.16 to 0.21). Per-protocol estimates were on average 5.5 (CI: 5.0 to 6.1) and 5.8 (CI: 5.3 to 6.3) respectively, with a mean difference of -0.25 (CI: -0.98 to 0.48), meeting the non-inferiority criteria. Adherence, based on proportion of reported sex acts covered by two gel doses, was 79.9% (CI: 76.7 to 83.2) in intervention compared with 73.9% (CI: 70.7 to 77.1) in control clinics; mean difference:6.0% (CI: 1.5 to 10.6) (p = 0.009). HIV incidence rates were 3.5 (CI: 1.8 to 6.0) and 3.6 (CI: 1.9 to 6.3) per 100 women-years in intervention and control clinics respectively. Both these incidence rates were lower than the age-standardized rate of 6.2 per 100 women-years (n = 444) in the placebo arm of the parent trial (p = 0.019). Conclusions: Provision of topical PrEP as part of an integrated FP service achieved higher adherence, and was as feasible, acceptable and effective in preventing HIV as provision through a research setting. This provides useful evidence for scale-up of oral PrEP in urban and rural high burden communities. Keywords: HIV prevention; pre-exposure prophylaxis (PrEP); tenofovir; adherence; integration into family planning services; implementation of PrEP scale-up, 1 | INTRODUCTION The Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004 trial [1] was the first to demonstrate that antiretroviral drugs used vaginally before and [...]

Published
2019
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25. The surge of mpox in Africa: a call for action

Author

Nachega, Jean B, Sam-Agudu, Nadia A, Ogoina, Dimie, Mbala-Kingebeni, Placide, Ntoumi, Francine, Nakouné, Emmanuel, Njouom, Richard, Lewis, Rosamund F, Gandhi, Monica, Rosenthal, Philip J, Rawat, Angeli, Wilson, Lindsay A, Kindrachuk, Jason, Liesenborghs, Laurens, Mills, Edward J, Preiser, Wolfgang, Rimoin, Anne W, Sullivan, Nancy J, Peeters, Martine, Delaporte, Eric, Baxter, Cheryl, Harrison, Lee, Hermans, Michel P, Mohr, Emma L, Gonsalves, Gregg, Ndembi, Nicaise, Zumla, Alimuddin, and Muyembe-Tamfum, Jean Jacques

Published
2024
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30. COVID-19 in Africa: Catalyzing change for sustainable development

Author

Abdool Karim, Salim S., Kelemu, Segenet, and Baxter, Cheryl

Subjects
Sustainable development -- Health aspects -- Management, Epidemics -- Control -- Social aspects -- Africa, Public health administration -- Evaluation, Company business management, Biological sciences
Abstract

Author(s): Salim S. Abdool Karim 1,2,*, Segenet Kelemu 3, Cheryl Baxter 1 Introduction The Coronavirus Disease 2019 (COVID-19) pandemic has dramatically changed everyone's lives, highlighting the fragility of systems providing [...]

Published
2021
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31. The genital tract and rectal microbiomes: their role in HIV susceptibility and prevention in women

Author

Karim, Salim S. Abdool, Baxter, Cheryl, Passmore, Jo-Ann S., McKinnon, Lyle R., and Williams, Brent L.

Subjects
Highly active antiretroviral therapy, Microbiota (Symbiotic organisms), HIV -- Prevention, Reproductive health, Infection -- Prevention, Antiretroviral agents, Women, Health
Abstract

Introduction: Young women in sub-Saharan Africa are disproportionately affected by HIV, accounting for 25% of all new infections in 2017. Several behavioural and biologicall factors are known to impact a young woman's vulnerability for acquiring HIV. One key but lesser understood, biologicall factor impacting vulnerability is the vaginal microbiome. This review describes the vaginal microbiome and examines its alterations, its influence on HIV acquisition as well as the efficacy of HIV prevention technologies, the role of the rectal microbiome in HIV acquisition, advandes in technologies to study the microbiome and some future research directions. Discussion: Although the composition of each woman's vaginal microbiome is unique, a microbiome dominated by Lactobacillus species is generally associated with a 'healthy' vagina. Disturbandes in the vaginal microbiota, characterized by a shift from a low-diversity, Lactobacillus-dominant state to a high-diversity non-Lactobacillus-dominant state, have been shown to be associated with a range of adverse reproductive health outcomes, including increasing the risk of genital inflammation and HIV acquisition. Gardnerella vaginalis and Prevotella bivia have been shown to contribute to both HIV risk and genital inflammation. In addition to impacting HIV risk, the composition of the vaginal microbiome affects the vaginal concentrations of some antiretroviral drugs, particularly those administered intravaginally and thereby their efficacy as pre-exposure prophylaxis (PrEP) for HIV prevention. Although the role of rectal microbiota in HIV acquisition in women is less well understood, the composition of this compartment's microbiome, particularly the presence of species of bacteria from the Prevotellaceae family likely contribute to HIV acquisition. Advandes in technologies have facilitated the study of the genital microbiome's structure and function. While next-generation sequencing advanded knowledge of the diversity and complexity of the vaginal microbiome, the emerging field of metaproteomics, which provides important information on vaginal bacterial community structure, diversity and function, is further shedding light on functionality of the vaginal microbiome and its relationship with bacterial vaginosis (BV), as well as antiretroviral PrEP efficacy. Conclusions: A better understanding of the composition, structure and function of the microbiome is needed to identify opportunities to alter the vaginal microbiome and prevent BV and reduce the risk of HIV acquisition. Keywords: HIV prevention; women; vaginal microbiome; rectal microbiome; genital inflammation; tenofovir ge, 1 | INTRODUCTION With 37 million people living with human immunodeficiency virus (HIV) and 1.8 million new infections in 2017, HIV remains a significant global public health problem. Sub-Saharan Africa [...]

Published
2019
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34. Evaluation of miniaturized Illumina DNA preparation protocols for SARS-CoV-2 whole genome sequencing

Author

Pillay, Sureshnee, primary, San, James Emmanuel, additional, Tshiabuila, Derek, additional, Naidoo, Yeshnee, additional, Pillay, Yusasha, additional, Maharaj, Akhil, additional, Anyaneji, Ugochukwu J., additional, Wilkinson, Eduan, additional, Tegally, Houriiyah, additional, Lessells, Richard J., additional, Baxter, Cheryl, additional, de Oliveira, Tulio, additional, and Giandhari, Jennifer, additional

Published
2023
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35. Molecular Epidemiology and Diversity of SARS-CoV-2 in Ethiopia, 2020–2022

Author

Sisay, Abay, primary, Tshiabuila, Derek, additional, van Wyk, Stephanie, additional, Tesfaye, Abraham, additional, Mboowa, Gerald, additional, Oyola, Samuel O., additional, Tesema, Sofonias Kifle, additional, Baxter, Cheryl, additional, Martin, Darren, additional, Lessells, Richard, additional, Tegally, Houriiyah, additional, Moir, Monika, additional, Giandhari, Jennifer, additional, Pillay, Sureshnee, additional, Singh, Lavanya, additional, Ramphal, Yajna, additional, Maharaj, Arisha, additional, Pillay, Yusasha, additional, Maharaj, Akhil, additional, Naidoo, Yeshnee, additional, Ramphal, Upasana, additional, Chabuka, Lucious, additional, Wilkinson, Eduan, additional, de Oliveira, Tulio, additional, Desta, Adey Feleke, additional, and San, James E., additional

Published
2023
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36. Comparing SARS-CoV-2 sequencing methodologies during early phase detection of the Delta variant in South Africa

Author

Ramphal, Upasana, primary, Tshiabuila, Derek, additional, Ramphal, Yajna, additional, Giandhari, Jennifer, additional, Heerden, Carel van, additional, Baxter, Cheryl, additional, wyk, Stephanie van, additional, Maharaj, Arisha, additional, Pillay, Sureshnee, additional, Laguda-Akingba, Oluwakemi, additional, San, James Emmanuel, additional, Wilkinson, Eduan, additional, Lessells, Richard, additional, and de Oliveira, Tulio, additional

Published
2023
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39. SARS-CoV-2 Africa dashboard for real-time COVID-19 information

Author

Xavier, Joicymara S., primary, Moir, Monika, additional, Tegally, Houriiyah, additional, Sitharam, Nikita, additional, Abdool Karim, Wasim, additional, San, James E., additional, Linhares, Joana, additional, Wilkinson, Eduan, additional, Ascher, David B., additional, Baxter, Cheryl, additional, Pires, Douglas E. V., additional, and de Oliveira, Tulio, additional

Published
2022
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40. Global Expansion of SARS-CoV-2 Variants of Concern: Dispersal Patterns and Influence of Air Travel

Author

Tegally, Houriiyah, primary, Wilkinson, Eduan, additional, Martin, Darren, additional, Moir, Monika, additional, Brito, Anderson, additional, Giovanetti, Marta, additional, Khan, Kamran, additional, Huber, Carmen, additional, Bogoch, Isaac I., additional, San, James Emmanuel, additional, Tsui, Joseph L.-H., additional, Poongavanan, Jenicca, additional, Xavier, Joicymara S., additional, Candido, Darlan da S., additional, Romero, Filipe, additional, Baxter, Cheryl, additional, Pybus, Oliver G., additional, Lessells, Richard, additional, Faria, Nuno R., additional, Kraemer, Moritz U.G., additional, and de Oliveira, Tulio, additional

Published
2022
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41. Microbicides for Prevention of HIV Infection: Clinical Efficacy Trials

Author

Abdool Karim, Salim S., Baxter, Cheryl, Compans, Richard W, Series editor, Cooper, Max D., Series editor, Gleba, Yuri Y., Series editor, Honjo, Tasuku, Series editor, Oldstone, Michael B. A., Series editor, Vogt, Peter K., Series editor, Malissen, Bernard, Series editor, Aktories, Klaus, Series editor, Kawaoka, Yoshihiro, Series editor, Rappuoli, Rino, Series editor, Galan, Jorge E., Series editor, Ahmed, Rafi, Series editor, and Nuttall, Jeremy, editor

Published
2014
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43. Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus

Author

Happi, Christian, primary, Adetifa, Ifedayo, additional, Mbala, Placide, additional, Njouom, Richard, additional, Nakoune, Emmanuel, additional, Happi, Anise, additional, Ndodo, Nnaemeka, additional, Ayansola, Oyeronke, additional, Mboowa, Gerald, additional, Bedford, Trevor, additional, Neher, Richard A., additional, Roemer, Cornelius, additional, Hodcroft, Emma, additional, Tegally, Houriiyah, additional, O’Toole, Áine, additional, Rambaut, Andrew, additional, Pybus, Oliver, additional, Kraemer, Moritz U. G., additional, Wilkinson, Eduan, additional, Isidro, Joana, additional, Borges, Vítor, additional, Pinto, Miguel, additional, Gomes, João Paulo, additional, Freitas, Lucas, additional, Resende, Paola C., additional, Lee, Raphael T. C., additional, Maurer-Stroh, Sebastian, additional, Baxter, Cheryl, additional, Lessells, Richard, additional, Ogwell, Ahmed E., additional, Kebede, Yenew, additional, Tessema, Sofonias K., additional, and de Oliveira, Tulio, additional

Published
2022
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44. Genital Inflammation and the Risk of HIV Acquisition in Women

Author

Masson, Lindi, Passmore, Jo-Ann S., Liebenberg, Lenine J., Werner, Lise, Baxter, Cheryl, Arnold, Kelly B., Wiliamson, Carolyn, Little, Francesca, Mansoor, Leila E., Naranbhai, Vivek, Lauffenburger, Douglas A., Ronacher, Katharina, Walzi, Gerhard, Garrett, Nigel J., Williams, Brent L., Couto-Rodriguez, Mara, Hornig, Mady, Lipkin, W. Ian, Grobler, Anneke, Karim, Quarraisha Abdool, and Karim, Salim S. Abdool

Published
2015

45. Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monkeypox virus [perspective]

Author

Happi, Christian, Adetifa, Ifedayo, Mbala, Placide, Njouom, Richard, Nakoune, Emmanuel, Happi, Anise, Ndodo, Nnaemeka, Ayansola, Oyeronke, Mboowa, Gerald, Bedford, Trevor, Neher, Richard A, Roemer, Cornelius, Hodcroft, Emma, Tegally, Houriiyah, O'Toole, Áine, Rambaut, Andrew, Pybus, Oliver, Kraemer, Moritz U G, Wilkinson, Eduan, Isidro, Joana, Borges, Vítor, Pinto, Miguel, Gomes, João Paulo, Freitas, Lucas, Resende, Paola C, Lee, Raphael T C, Maurer-Stroh, Sebastian, Baxter, Cheryl, Lessells, Richard, Ogwell, Ahmed E, Kebede, Yenew, Tessema, Sofonias K, and de Oliveira, Tulio

Subjects
360 Social problems & social services, 610 Medicine & health
Abstract

We propose a novel, non-discriminatory classification of monkeypox virus. Together with the World Health Organization, we named three clades (I, IIa and IIb) in order of detection. Within IIb, the cause the current global outbreak, we identified multiple lineages (A.1, A.2, A.1.1 and B.1) to support real-time genomics surveillance.

Published
2022

47. Mechanisms of sexually transmitted infection‐induced inflammation in women: implications for HIV risk

Author

Mwatelah, Ruth, Mckinnon, Lyle R., Baxter, Cheryl, Karim, Quarraisha Abdool, and Karim, Salim S Abdool

Subjects
Women -- Health aspects, Sexually transmitted diseases -- Complications and side effects, Inflammation -- Risk factors -- Causes of, Immune response -- Health aspects, HIV infection -- Risk factors, Health
Abstract

: Introduction: Globally, sexually transmitted infections (STI) affect >300 million people annually, and are a major cause of sexual and reproductive health complications in women. In this commentary, we describe how STIs interact with the immune and non‐immune cells, both within and below the cervicovaginal mucosal barrier, to cause inflammation, which in turn has been associated with increased HIV acquisition risk. Discussion: STIs have a major impact on the female genital mucosa, which is an important biological and physical barrier that forms the first line of defence against invading microorganisms such as HIV. Pattern recognition of STI pathogens, by receptors expressed either on the cell surface or inside the cell, typically triggers inflammation at the mucosal barrier. The types of mucosal responses vary by STI, and can be asymptomatic or culminate in the formation of discharge, ulcers and/or warts. While the aim of this response is to clear the invading microbes, in many cases these responses are either evaded or cause pathology that impairs barrier integrity and increases HIV access to target cells in the sub‐mucosa. In addition, innate responses to STIs can result in an increased number of immune cells, including those that are the primary targets of HIV, and may contribute to the association between STIs and increased susceptibility to HIV acquisition. Many of these cells are mediators of adaptive immunity, including tissue‐resident cells that may also display innate‐like functions. Bacterial vaginosis (BV) is another common cause of inflammation, and evidence for multiple interactions between BV, STIs and HIV suggest that susceptibility to these conditions should be considered in concert. Conclusions: STIs and other microbes can induce inflammation in the genital tract, perturbing the normal robust function of the mucosal barrier against HIV. While the impact of STIs on the mucosal immune system and HIV acquisition is often under‐appreciated, understanding their interactions of the infections with the immune responses play an important role in improving treatment and reducing the risk of HIV acquisition. The frequent sub‐clinical inflammation associated with STIs underscores the need for better STI diagnostics to reverse the immunological consequences of infection., Introduction There are over 50 types of viruses, bacteria and parasites that can be sexually transmitted, eight of which are most widely recognized as sexually transmitted infections (STIs). These include [...]

Published
2019
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50. The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

Author

Tegally, Houriiyah, primary, San, James E., additional, Cotten, Matthew, additional, Tegomoh, Bryan, additional, Mboowa, Gerald, additional, Martin, Darren P., additional, Baxter, Cheryl, additional, Moir, Monika, additional, Lambisia, Arnold, additional, Diallo, Amadou, additional, Amoako, Daniel G., additional, Diagne, Moussa M., additional, Sisay, Abay, additional, Zekri, Abdel-Rahman N., additional, Barakat, Abdelhamid, additional, Gueye, Abdou Salam, additional, Sangare, Abdoul K., additional, Ouedraogo, Abdoul-Salam, additional, Sow, Abdourahmane, additional, Musa, Abdualmoniem O., additional, Sesay, Abdul K., additional, Lagare, Adamou, additional, Kemi, Adedotun-Sulaiman, additional, Abar, Aden Elmi, additional, Johnson, Adeniji A., additional, Fowotade, Adeola, additional, Olubusuyi, Adewumi M., additional, Oluwapelumi, Adeyemi O., additional, Amuri, Adrienne A., additional, Juru, Agnes, additional, Ramadan, Ahmad Mabrouk, additional, Kandeil, Ahmed, additional, Mostafa, Ahmed, additional, Rebai, Ahmed, additional, Sayed, Ahmed, additional, Kazeem, Akano, additional, Balde, Aladje, additional, Christoffels, Alan, additional, Trotter, Alexander J., additional, Campbell, Allan, additional, Keita, Alpha Kabinet, additional, Kone, Amadou, additional, Bouzid, Amal, additional, Souissi, Amal, additional, Agweyu, Ambrose, additional, Gutierrez, Ana V., additional, Page, Andrew J., additional, Yadouleton, Anges, additional, Vinze, Anika, additional, Happi, Anise N., additional, Chouikha, Anissa, additional, Iranzadeh, Arash, additional, Maharaj, Arisha, additional, Batchi-Bouyou, Armel Landry, additional, Ismail, Arshad, additional, Sylverken, Augustina, additional, Goba, Augustine, additional, Femi, Ayoade, additional, Sijuwola, Ayotunde Elijah, additional, Ibrahimi, Azeddine, additional, Marycelin, Baba, additional, Salako, Babatunde Lawal, additional, Oderinde, Bamidele S., additional, Bolajoko, Bankole, additional, Dhaala, Beatrice, additional, Herring, Belinda L., additional, Tsofa, Benjamin, additional, Mvula, Bernard, additional, Njanpop-Lafourcade, Berthe-Marie, additional, Marondera, Blessing T., additional, Khaireh, Bouh Abdi, additional, Kouriba, Bourema, additional, Adu, Bright, additional, Pool, Brigitte, additional, McInnis, Bronwyn, additional, Brook, Cara, additional, Williamson, Carolyn, additional, Anscombe, Catherine, additional, Pratt, Catherine B., additional, Scheepers, Cathrine, additional, Akoua-Koffi, Chantal G., additional, Agoti, Charles N., additional, Loucoubar, Cheikh, additional, Onwuamah, Chika Kingsley, additional, Ihekweazu, Chikwe, additional, Malaka, Christian Noël, additional, Peyrefitte, Christophe, additional, Omoruyi, Chukwuma Ewean, additional, Rafaï, Clotaire Donatien, additional, Morang’a, Collins M., additional, Nokes, D. James, additional, Lule, Daniel Bugembe, additional, Bridges, Daniel J., additional, Mukadi-Bamuleka, Daniel, additional, Park, Danny, additional, Baker, David, additional, Doolabh, Deelan, additional, Ssemwanga, Deogratius, additional, Tshiabuila, Derek, additional, Bassirou, Diarra, additional, Amuzu, Dominic S.Y., additional, Goedhals, Dominique, additional, Grant, Donald S., additional, Omuoyo, Donwilliams O., additional, Maruapula, Dorcas, additional, Wanjohi, Dorcas Waruguru, additional, Foster-Nyarko, Ebenezer, additional, Lusamaki, Eddy K., additional, Simulundu, Edgar, additional, Ong’era, Edidah M., additional, Ngabana, Edith N., additional, Abworo, Edward O., additional, Otieno, Edward, additional, Shumba, Edwin, additional, Barasa, Edwine, additional, Ahmed, El Bara, additional, Kampira, Elizabeth, additional, Fahime, Elmostafa El, additional, Lokilo, Emmanuel, additional, Mukantwari, Enatha, additional, Cyril, Erameh, additional, Philomena, Eromon, additional, Belarbi, Essia, additional, Simon-Loriere, Etienne, additional, Anoh, Etilé A., additional, Leendertz, Fabian, additional, Taweh, Fahn M., additional, Wasfi, Fares, additional, Abdelmoula, Fatma, additional, Takawira, Faustinos T., additional, Derrar, Fawzi, additional, Ajogbasile, Fehintola V, additional, Treurnicht, Florette, additional, Onikepe, Folarin, additional, Ntoumi, Francine, additional, Muyembe, Francisca M., additional, Ngiambudulu, Francisco, additional, Zongo Ragomzingba, Frank Edgard, additional, Dratibi, Fred Athanasius, additional, Iyanu, Fred-Akintunwa, additional, Mbunsu, Gabriel K., additional, Thilliez, Gaetan, additional, Kay, Gemma L., additional, Akpede, George O., additional, George, Uwem E., additional, van Zyl, Gert, additional, Awandare, Gordon A., additional, Schubert, Grit, additional, Maphalala, Gugu P., additional, Ranaivoson, Hafaliana C., additional, Lemriss, Hajar, additional, Omunakwe, Hannah E, additional, Onywera, Harris, additional, Abe, Haruka, additional, Karray, Hela, additional, Nansumba, Hellen, additional, Triki, Henda, additional, Adje Kadjo, Herve Albéric, additional, Elgahzaly, Hesham, additional, Gumbo, Hlanai, additional, mathieu, Hota, additional, Kavunga-Membo, Hugo, additional, Smeti, Ibtihel, additional, Olawoye, Idowu B., additional, Adetifa, Ifedayo, additional, Odia, Ikponmwosa, additional, Boubaker, Ilhem Boutiba-Ben, additional, Ssewanyana, Isaac, additional, Wurie, Isatta, additional, Konstantinus, Iyaloo S, additional, Afiwa Halatoko, Jacqueline Wemboo, additional, Ayei, James, additional, Sonoo, Janaki, additional, Lekana-Douki, Jean Bernard, additional, Makangara, Jean-Claude C., additional, Tamfum, Jean-Jacques M., additional, Heraud, Jean-Michel, additional, Shaffer, Jeffrey G., additional, Giandhari, Jennifer, additional, Musyoki, Jennifer, additional, Uwanibe, Jessica N., additional, Bhiman, Jinal N., additional, Yasuda, Jiro, additional, Morais, Joana, additional, Mends, Joana Q., additional, Kiconco, Jocelyn, additional, Sandi, John Demby, additional, Huddleston, John, additional, Odoom, John Kofi, additional, Morobe, John M., additional, Gyapong, John O., additional, Kayiwa, John T., additional, Okolie, Johnson C., additional, Xavier, Joicymara Santos, additional, Gyamfi, Jones, additional, Kofi Bonney, Joseph Humphrey, additional, Nyandwi, Joseph, additional, Everatt, Josie, additional, Farah, Jouali, additional, Nakaseegu, Joweria, additional, Ngoi, Joyce M., additional, Namulondo, Joyce, additional, Oguzie, Judith U., additional, Andeko, Julia C., additional, Lutwama, Julius J., additional, O’Grady, Justin, additional, Siddle, Katherine J, additional, Victoir, Kathleen, additional, Adeyemi, Kayode T., additional, Tumedi, Kefentse A., additional, Carvalho, Kevin Sanders, additional, Mohammed, Khadija Said, additional, Musonda, Kunda G., additional, Duedu, Kwabena O., additional, Belyamani, Lahcen, additional, Fki-Berrajah, Lamia, additional, Singh, Lavanya, additional, Biscornet, Leon, additional, de Oliveira Martins, Leonardo, additional, Chabuka, Lucious, additional, Olubayo, Luicer, additional, Deng, Lul Lojok, additional, Ochola-Oyier, Lynette Isabella, additional, Mine, Madisa, additional, Ramuth, Magalutcheemee, additional, Mastouri, Maha, additional, ElHefnawi, Mahmoud, additional, Mbanne, Maimouna, additional, Matsheka, Maitshwarelo I., additional, Kebabonye, Malebogo, additional, Diop, Mamadou, additional, Momoh, Mambu, additional, Lima Mendonça, Maria da Luz, additional, Venter, Marietjie, additional, Paye, Marietou F, additional, Faye, Martin, additional, Nyaga, Martin M., additional, Mareka, Mathabo, additional, Damaris, Matoke-Muhia, additional, Mburu, Maureen W., additional, Mpina, Maximillian, additional, Claujens Chastel, Mfoutou Mapanguy, additional, Owusu, Michael, additional, Wiley, Michael R., additional, Tatfeng, Mirabeau Youtchou, additional, Ayekaba, Mitoha Ondo’o, additional, Abouelhoda, Mohamed, additional, Beloufa, Mohamed Amine, additional, Seadawy, Mohamed G, additional, Khalifa, Mohamed K., additional, Dellagi, Mohammed Koussai, additional, Matobo, Mooko Marethabile, additional, Kane, Mouhamed, additional, Ouadghiri, Mouna, additional, Salou, Mounerou, additional, Mbulawa, Mphaphi B., additional, Saibu, Mudashiru Femi, additional, Mwenda, Mulenga, additional, Kaba, Muluken, additional, Phan, My V.T., additional, Abid, Nabil, additional, Touil, Nadia, additional, Rujeni, Nadine, additional, Ismael, Nalia, additional, Top, Ndeye Marieme, additional, Dia, Ndongo, additional, Mabunda, Nédio, additional, Hsiao, Nei-yuan, additional, Silochi, Nelson Boricó, additional, Saasa, Ngonda, additional, Bbosa, Nicholas, additional, Murunga, Nickson, additional, Gumede, Nicksy, additional, Wolter, Nicole, additional, Sitharam, Nikita, additional, Ndodo, Nnaemeka, additional, Ajayi, Nnennaya A., additional, Tordo, Noël, additional, Mbhele, Nokuzola, additional, Razanajatovo, Norosoa H, additional, Iguosadolo, Nosamiefan, additional, Mba, Nwando, additional, Kingsley, Ojide C., additional, Sylvanus, Okogbenin, additional, Peter, Okokhere, additional, Femi, Oladiji, additional, Testimony, Olumade, additional, Ogunsanya, Olusola Akinola, additional, Fakayode, Oluwatosin, additional, Ogah, Onwe E., additional, Faye, Ousmane, additional, Smith-Lawrence, Pamela, additional, Ondoa, Pascale, additional, Combe, Patrice, additional, Nabisubi, Patricia, additional, Semanda, Patrick, additional, Oluniyi, Paul E., additional, Arnaldo, Paulo, additional, Quashie, Peter Kojo, additional, Bejon, Philip, additional, Dussart, Philippe, additional, Bester, Phillip A., additional, Mbala, Placide K., additional, Kaleebu, Pontiano, additional, Abechi, Priscilla, additional, El-Shesheny, Rabeh, additional, Joseph, Rageema, additional, Aziz, Ramy Karam, additional, Essomba, René Ghislain, additional, Ayivor-Djanie, Reuben, additional, Njouom, Richard, additional, Phillips, Richard O., additional, Gorman, Richmond, 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Stephanie, additional, Schaffner, Stephen F., additional, Kanyerezi, Stephen, additional, Ahuka-Mundeke, Steve, additional, Rudder, Steven, additional, Pillay, Sureshnee, additional, Nabadda, Susan, additional, Behillil, Sylvie, additional, Budiaki, Sylvie L., additional, van der Werf, Sylvie, additional, Mashe, Tapfumanei, additional, Aanniz, Tarik, additional, Mohale, Thabo, additional, Le-Viet, Thanh, additional, Velavan, Thirumalaisamy P., additional, Schindler, Tobias, additional, Maponga, Tongai, additional, Bedford, Trevor, additional, Anyaneji, Ugochukwu J., additional, Chinedu, Ugwu, additional, Ramphal, Upasana, additional, Enouf, Vincent, additional, Nene, Vishvanath, additional, Gorova, Vivianne, additional, Roshdy, Wael H., additional, Karim, Wasim Abdul, additional, Ampofo, William K., additional, Preiser, Wolfgang, additional, Choga, Wonderful T., additional, Ahmed, Yahaya Ali, additional, Ramphal, Yajna, additional, Bediako, Yaw, additional, Naidoo, Yeshnee, additional, Butera, Yvan, additional, de Laurent, Zaydah R., additional, Ouma, Ahmed E.O., additional, von Gottberg, Anne, additional, Githinji, George, additional, Moeti, Matshidiso, additional, Tomori, Oyewale, additional, Sabeti, Pardis C., additional, Sall, Amadou A., additional, Oyola, Samuel O., additional, Tebeje, Yenew K., additional, Tessema, Sofonias K., additional, de Oliveira, Tulio, additional, Happi, Christian, additional, Lessells, Richard, additional, Nkengasong, John, additional, and Wilkinson, Eduan, additional

Published
2022
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