32 results on '"Bazin T"'
Search Results
2. Hydroxyapatite dopée au cuivre : de la poudre au matériau biocompatible
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Bazin, T., Magnaudeix, Amandine, Carles, Pierre, Duttine, M., Demourgues, A., Julien, Isabelle, Gaudon, M., Champion, Eric, DERORY, BEATRICE, IRCER - Axe 4 : céramiques sous contraintes environnementales (IRCER-AXE4), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
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[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,ComputingMilieux_MISCELLANEOUS ,[SPI.MAT]Engineering Sciences [physics]/Materials - Abstract
National audience
- Published
- 2019
3. Hydroxyapatite doped with transition elements: from powder to biocompatible material
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Bazin, T., Magnaudeix, Amandine, Demourgues, A., Julien, Isabelle, Gaudon, M., Champion, Eric, DERORY, BEATRICE, IRCER - Axe 3 : organisation structurale multiéchelle des matériaux (IRCER-AXE3), Institut de Recherche sur les CERamiques (IRCER), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and IRCER - Axe 4 : céramiques sous contraintes environnementales (IRCER-AXE4)
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[CHIM.MATE] Chemical Sciences/Material chemistry ,[CHIM.MATE]Chemical Sciences/Material chemistry ,[SPI.MAT] Engineering Sciences [physics]/Materials ,ComputingMilieux_MISCELLANEOUS ,[SPI.MAT]Engineering Sciences [physics]/Materials - Abstract
International audience
- Published
- 2019
4. Host-microbiota co-immunity : An intimate relationship that goes beyond defense Position paper for PTPBio
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Bazin, T., Chiu, L., Pradeu, Thomas, Bazin, T., Chiu, L., and Pradeu, Thomas
- Abstract
Resident microorganisms, known as the microbiota, are essential for many physiological functions including protection against pathogens. Microbiota is indeed required for proper immune system development and function, and can also host-independently protect against infections. Thus, a coconstructed view of host defense involving both host and microbiota, named “co-immunity”, has been proposed, and the idea of an “immunological holobiont” has been suggested. Yet this view of coimmunity might be too limited, as experimental work has shown that the immune system is involved in functions other than defense, essentially development and repair. Microbiota, through coimmunity, is thereby most likely involved in these functions, although strong evidence is currently lacking. Moreover, as our point of view is mainly host-centered, we may miss the implications of coimmunity at broaderscales, including cellular and populational levels. Intriguingly, co-immunity effects could be beneficial for one function and/or one level, while detrimental for others. All these elements should be taken into consideration for microbiota manipulation, in order to avoid potentially harmful side effects.
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- 2018
5. Impact of intravenous antibiotics on the gut microbiota in children with cystic fibrosis
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Enaud, R., Bazin, T., Barré, A., Barnetche, T., Hubert, Cédric, Clouzeau, H., Bui, S., Nikolski, M., Lehours, P., Bébéar, C., Lamireu, T., Schaeverbeke, T., Centre National de la Recherche Scientifique (CNRS), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB), Centre de Bioinformatique de Bordeaux (CBIB), and CGFB
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[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2017
- Full Text
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6. 173 Impact of intravenous antibiotics on the gut microbiota in children with cystic fibrosis
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Enaud, R., primary, Bazin, T., additional, Barré, A., additional, Barnetche, T., additional, Hubert, C., additional, Clouzeau, H., additional, Bui, S., additional, Nikolski, M., additional, Lehours, P., additional, Bébéar, C., additional, Lamireu, T., additional, and Schaeverbeke, T., additional
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- 2017
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7. Effects of dopamine inhalation on oxygenation and extravascular lung water during severe ARDS
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Gillart, T., primary, Value, J. L., additional, Guelon, D., additional, Bazin, T. E., additional, and Schoeffler, P., additional
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- 2001
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8. Study of the information delivery by general practitioners and rheumatologists to patients with acute low back pain.
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Henrotin Y, Moyse D, Bazin T, Cedraschi C, Duplan B, Duquesnoy B, Laroche F, Valat JP, Marty M, Henrotin, Yves, Moyse, Dominique, Bazin, Thierry, Cedraschi, Christine, Duplan, Bernard, Duquesnoy, Bernard, Laroche, Francoise, Valat, Jean-Pierre, and Marty, Marc
- Abstract
Providing information to patients regarding appropriate management of LBP is a crucial component of primary care and treatment of low back pain (LBP). Limited knowledge is available, however, about the information delivered by physicians to patients with low back pain. Hence, this study aimed at evaluating (1) the self-reported practices of French physicians concerning information about patients with acute LBP (2) the consistency of these practices with the COST B13 guidelines, and (3) the effects of the delivery of a leaflet summarizing the COST B13 recommendations on the management of patient information, using the following study design: 528 French physicians [319 general practitioners (GP) and 209 rheumatologists (RH)] were asked to provide demographic information, responses to a Fear Avoidance Beliefs questionnaire adapted for physicians and responses to a questionnaire investigating the consistency of their practice with the COST B13 guidelines. Half of the participants (163 GP and 105 RH) were randomized to receive a summary of the COST B13 guidelines concerning information delivery to patient with low back pain and half (156 GP and 104 RH) were not given this information. The mean age of physicians was 52.1±7.6 years, 25.2% were females, 75% work in private practice, 63.1% reported to treat 10-50 patients with LBP per month and 18.2%<10 per month. The majority of the physicians (71.0%) reported personal LBP episode (7.1% with a duration superior to 3 months). Among the 18.4% (97) of the physicians that knew the COST B13 guidelines, 85.6% (83/97) reported that they totally or partially applied these recommendations in their practice. The average work (0-24) and physical activity (0-24) FABQ scores were 21.2±8.4 and 10.1±6.0, respectively. The consistency scores (11 questions scored 0 to 6, total score was standardized from 0 to 100) were significantly higher in the RH group (75.6±11.6) than in GP group (67.2±12.6; p<0.001). The delivery of a summary of the COST B13 guidelines significantly improved the consistency score (p=0.018). However, a multivariate analysis indicated that only GP consistency was improved by recommendations' delivery.The results indicated that GP were less consistent with the European COST B13 guidelines on the information of patients with acute LBP than RH. Interestingly, delivery of a summary of these guidelines to GP improved their consistency score, but not that of the RH. This suggests that GP information campaign can modify the message that they deliver to LBP, and subsequently could change patient's beliefs on LBP. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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9. Development and validation of a questionnaire assessing volitional competencies to enhance the performance of physical activities in chronic low back pain patients
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Duplan Bernard, Legout Valérie, Genevay Stéphane, Marty Marc, Henrotin Yves, Broonen Jean-Paul, Mathy Céline, Bazin Thierry, Laroche Françoise, Savarieau Bernard, and Cedraschi Christine
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Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Motivation has long been emphasized as the most important determinant of action. However, there is a substantial gap between people's goals and their attainment. Patients may be motivated and yet unable to take action if their volitional competencies are insufficient. One of the important tasks of volition is goal-maintenance. Research has stressed the importance of a volitional tool, the implementation intentions. Implementation intentions indicate where, when, and how the action leading to the goal will be performed. Forming implementation intentions favours the execution of goal-directed efforts, and reinforces the relationship between intentions and behaviours. Results from various studies clearly suggest that volitional competencies and implementation intentions could play a role in low back pain (LBP) patients. However, there is at present no questionnaire allowing assessing the capacity of implementation intentions of physical activities in LBP patients. Methods/Design This study will develop such a questionnaire, using a 3-step approach. A first qualitative step to build categories and generate items; 30 patients suffering chronic LBP will be invited to participate in semi-structured interviews; verbatim and derived items will then be submitted to a panel of experts, using a Delphi method; a second quantitative step to examine the properties of items, and determine the factorial structure of the questionnaire; 100 patients suffering chronic LBP will be recruited to respond to this phase; and third, preliminary psychometric analyses (item-scale correlations, construct validity, reliability); 180 chronic LBP patients will be recruited for this phase of the study. The relationships between implementation intentions and variables affecting physical activity on chronic LBP patients, i.e. pain, physical capacities, fear-avoidance beliefs, kinesiophobia, work status, and level of physical activity will be considered. Discussion Developing a questionnaire to assess implementation intentions would allow investigating the role of these intentions in the transition from acute to chronic LBP. The results of this study should contribute to the understanding of the psychological processes at stake in the development of chronic LBP, and in particular to the identification of factors eventually favouring patients' participation in and adherence to active physical treatments.
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- 2011
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10. Top-down infliximab plus azathioprine versus azathioprine alone in patients with acute severe ulcerative colitis responsive to intravenous steroids: a parallel, open-label randomised controlled trial, the ACTIVE trial.
- Author
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Amiot A, Seksik P, Meyer A, Stefanescu C, Wils P, Altwegg R, Vuitton L, Plastaras L, Nicolau A, Pereira B, Duveau N, Laharie D, Mboup B, Boualit M, Allez M, Rajca S, Chanteloup E, Bouguen G, Bazin T, Goutorbe F, Richard N, Moussata D, Vicaut E, and Peyrin-Biroulet L
- Abstract
Background: It is unknown which maintenance therapy is the most effective option for patients admitted for an acute severe ulcerative colitis (ASUC) episode responding to intravenous steroids., Methods: We conducted a multicentre, parallel-group, open-label randomised controlled trial among 23 French centres in thiopurine and biologics-naïve adults admitted for ASUC responding to intravenous steroids. Eligible patients were randomly assigned to receive infliximab (IFX) and azathioprine (AZA) with a 7-day steroid tapering scheme (IFX+AZA arm) or AZA and conventional standardised steroid tapering regimen (AZA arm). The primary composite endpoint was treatment failure at week 52, defined as the absence of steroid-free clinical remission, the absence of endoscopic response, the use of a prohibited treatment for relapse, severe adverse event leading to treatment interruption, colectomy or death. Multiple imputation for missing data was performed., Findings: Among the 64 patients randomised (Lichtiger score 13.5±2.0; median age of 34.5 (P25-P75 26.3-50.3) years, median C reactive protein of 29.0 (12.8-96.8) mg/L at baseline): 32 were assigned to the IFX+AZA arm and 32 to the AZA arm. In the ITT population, treatment failure at week 52 was observed in 22/27 (81.5%) in the AZA arm and 16/30 (53.3%) in the IFX+AZA arm (risk ratio 3.85, 95% CI (1.15 to 12.88), p=0.03). 29 adverse events were severe, including 13 disease exacerbations, 6 severe infections without any difference between both arms., Interpretation: Combination therapy with IFX+AZA was more effective at 1 year than AZA alone to avoid treatment failure in patients with ASUC responding to intravenous steroids., Trial Registration Number: NCT02425852., Competing Interests: Competing interests: AA received consulting fees from Abbvie, Pfizer, Takeda, Tillotts Pharma, Janssen and Sandoz as well as lecture fees and travel accommodations from Abbvie, Janssen, Pfizer, Takeda, Biogen, Fresenius Kabi, Amgen and Celltrion. PS reports consulting fees from Pfizer, Astellas, Janssen, Fresenius Kabi, Takeda, Abbvie, Merck-MSD, Pilège, Lilly, Celltrion and Biocodex; and grants from Biocodex and Janssen. CS declare lecture and/or consulting fees from Abbvie, Amgen, Celltrion, Janssen, Lilly, Takeda, Tillots. PW received board membership, consultancy, or lecture fees from Abbvie, Amgen, Celltrion, Ferring, Janssen, and Takeda. LV received fees from Abbvie, Amgen, MSD, Ferring, Takeda, Pfizer, Celltrion, Janssen, Galapagos, Dr Falk. RA declares lecture fees from MSD, Abbvie, Pfizer, Takeda, and Janssen. GB received lecture fees from Abbvie, Ferring, Takeda and Pfizer and consultant fees from Takeda, Janssen, Lilly, Celltrion, Sandoz, Abbvie. MB has received lecture fees and travel accommodation from Abbvie, Fresenius Kabi, Janssen, Pfizer and Takeda. DL has received counseling, boards, transports and/or fees from Abbvie, Amgen, Biogen, Ferring, Galapagos, Janssen, Lilly, MSD, Novartis, Pfizer, Prometheus, Roche, Takeda, Tillots. MA has served as a speaker, consultant, and/or advisory board member for Abbvie, Amgen, Biogen, Boehringer-Ingelheim, Celgene, Celltrion, Ferring, Galapagos, Genentech, IQVIA, Janssen, Lilly, MSD, Pfizer, Roche, Takeda, Tillotts. FG declares counseling, boards, transports and lectures fees from Abbvie, Amgen, Biogen, Celltrion, Janssen, Lilly, MSD, Pfizer, Takeda. NR has received lecture fees from AbbVie and Takeda. LP-B received consulting fees from Merck, Abbvie, Janssen, Genentech, Ferring, Norgine, Tillots, Vifor, Shire, Therakos, Pharmacosmos, Pilège, BMS, UCB-Pharma, Hospira, Celltrion, Takeda, Biogaran, Boerhinger-Ingelheim, Lilly, Pfizer and HAC-Pharma. This author also received lecture fees from Merck, Abbvie, Takeda, Janssen Cilag, Ferring, Norgine, Tillots, Vifor, Therakos, HAC-Pharma and Mitsubishi. No conflicts of interest are claimed by the remaining authors., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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11. Copper Versatility in Hydroxyapatite: Valence States, Clusters, and Optical Absorption Properties.
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Bazin T, Gaudon M, Champion E, Julien I, Prestipino C, Figueroa SJA, Duttine M, and Demourgues A
- Abstract
The solid-state reaction between a stoichiometric hydroxyapatite (HA) and CuO at temperatures above 1100 °C produces pure Cu
x -HA phases for x ≤ 0.7 with the general formula Ca10 CuI x (PO4 )6 (OH)2- x Ox . The Cu atoms are located at the center of the hexagonal tunnels between two hydroxyl ligands, as determined by Fourier analysis based on XRD data. During heat treatment, the reduction of Cu2+ ions into Cu+ is concomitant with the stabilization of copper in HA in the hexagonal tunnel. The incorporation of monovalent copper within the apatite, as revealed by XANES spectroscopy, explains the violet color of the samples. The incorporation of Cu+ ions, by substitution of a hydrogen atom by copper(I), results in the formation of linear O-Cu-O chains where the majority of which are isolated for x ≤ 0.3. In addition, the EXAFS investigation showed, thanks to the linear geometry of these clusters that results in multiple diffusion effects, the existence of [CuO]n chains with n ≥ 2, which only appear clearly for higher copper contents x ≥ 0.5. The strong covalency of the Cu-O bond in such a dumbbell configuration would lead to strong hybridization between the 3d and 4s orbitals of copper and the 2p orbitals of oxygen, as illustrated by ESR signals. In the case of Cu-doped HA prepared by coprecipitation and annealed at a lower temperature ( T ≤ 600 °C), copper substitutes calcium according to the theoretical formula Ca10- x Cux (PO4 )6 (OH)2 , mainly at the Ca(2) site. This local environment is in line with the Jahn-Teller distortion induced by the Cu2+ ion (as evidenced by UV-vis-NIR, XPS, and XANES-EXAFS spectroscopy analyses) and also allows copper-copper interactions from one site to another, as observed by ESR spectroscopy. This versatility of copper in HA gives it optical properties that change from a violet color with near-IR absorption to a blue hue. In all cases, Cu-O-Cu interactions persist whatever the valence state, and heat treatment induces a redox phenomenon, with copper exchanging between two sites close to each other.- Published
- 2024
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12. Protein Biomarkers of Gastric Preneoplasia and Cancer Lesions in Blood: A Comprehensive Review.
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Bazin T, Nozeret K, Julié C, Lamarque D, and Touati E
- Abstract
Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. It is often associated with a bad prognosis because of its asymptomatic phenotype until advanced stages, highlighting the need for its prevention and early detection. GC development is preceded by the emergence of gastric preneoplasia lesions (GPNLs), namely atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia (DYS). GC is currently diagnosed by endoscopy, which is invasive and costly and has limited effectiveness for the detection of GPNLs. Therefore, the discovery of non-invasive biomarkers in liquid biopsies, such as blood samples, in order to identify the presence of gastric preneoplasia and/or cancer lesions at asymptomatic stages is of paramount interest. This comprehensive review provides an overview of recently identified plasma/serum proteins and their diagnostic performance for the prediction of GPNLs and early cancer lesions. Autoantibodies appear to be promising biomarkers for AG, IM and early gastric cancer detection, along with inflammation and immunity-related proteins and antibodies against H. pylori virulence factors. There is a lack of specific protein biomarkers with which to detect DYS. Despite the need for further investigation and validation, some emerging candidates could pave the way for the development of reliable, non-invasive diagnostic tests for the detection and prevention of GC.
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- 2024
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13. Review and Consultations of Canadian Financial Education Programs for Individuals with Disabilities.
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Engel L, Rampling T, Brautigan EJ, Bazin T, Dilts K, Williams T, Dyck TM, Jack EM, and Colquhoun H
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- Humans, Canada, Disabled Persons education, Occupational Therapy
- Abstract
Background. Individuals or persons who live with a disability (PWD) can experience unique financial occupation challenges. Financial education programs can address some challenges. Purpose. The aim of this study was to describe and critically appraise current financial education programs for PWD in Canada. Method. This environmental scan framed by scoping review methods included a critical appraisal of Canadian programs' online content and provider consultations. Researchers used four search methods to identify programs, interviewed service providers from four Canadian programs, and thematically analyzed interview transcripts. Findings. Researchers identified 134 programs; 50 (37.3%) included services. The online content of only 26 (19%) programs explicitly addressed accessibility; 106 (79%) programs' content was at least college reading level. The qualitative results include three themes: (a) individualized approach, (b) "getting the word out", and (c) service growth. Implications. There are financial education programs specific to PWD in Canada. Accessibility, individualization, advocacy, and development are needed.
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- 2023
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14. Exotic Fe II /Fe III Local Environments in the Hexagonal Channels of Hydroxyapatite.
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Bazin T, Duttine M, Julien I, Champion E, Demourgues A, and Gaudon M
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- Ferrous Compounds chemistry, Iron chemistry, Models, Molecular, Spectroscopy, Mossbauer, Durapatite, Ferric Compounds chemistry
- Abstract
In this fundamental solid-state chemistry study, two sample series were investigated in depth: iron(III)-doped hydroxyapatite (HA) compounds obtained from a co-sintering process of hematite and pure HA under air and iron(III)-doped HA compounds obtained from a co-sintering process from iron(II) acetate and pure HA under an argon atmosphere. X-ray diffraction, UV-visible, Fourier transform infrared,
1 H and31 P NMR, electron paramagnetic resonance (EPR,) and Mössbauer spectroscopy methods were coupled to unravel the Fe valence states, the interactions with other anionic species (OH- and PO4 3- ), and finally the complex local environments in hexagonal channels in both the series. In particular, we highlighted the associated mechanism to ensure electroneutrality with a focus on deprotonation versus calcium substitution. By diverging mechanisms, Fe3+ and Fe2+ ions were found to be located in different coordinated sites: 4(+1) coordinated site for Fe3+ and 2(+3) coordinated site for Fe2+ and clearly associated with very different Mössbauer and EPR signatures as various absorption bands (leading to different sample colors).- Published
- 2022
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15. Management of Non-response and Loss of Response to Anti-tumor Necrosis Factor Therapy in Inflammatory Bowel Disease.
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Marsal J, Barreiro-de Acosta M, Blumenstein I, Cappello M, Bazin T, and Sebastian S
- Abstract
Anti-tumor necrosis factor (anti-TNF) therapy has been successfully used as first-line biologic treatment for moderate-to-severe inflammatory bowel disease (IBD), in both "step-up" and "top-down" approaches, and has become a cornerstone of IBD management. However, in a proportion of patients the effectiveness of anti-TNF therapy is sub-optimal. Either patients do not achieve adequate initial response (primary non-response) or they lose response after initial success (loss of response). Therapeutic drug monitoring determines drug serum concentrations and the presence of anti-drug antibodies (ADAbs) and can help guide treatment optimization to improve patient outcomes. For patients with low drug concentrations who are ADAb-negative or display low levels of ADAbs, dose escalation is recommended. Should response remain unchanged following dose optimization the question whether to switch within class (anti-TNF) or out of class (different mechanism of action) arises. If ADAb levels are high and the patient has previously benefited from anti-TNF therapy, then switching within class is a viable option as ADAbs are molecule specific. Addition of an immunomodulator may lead to a decrease in ADAbs and a regaining of response in a proportion of patients. If a patient does not achieve a robust therapeutic response with an initial anti-TNF despite adequate drug levels, then switching out of class is appropriate. In conjunction with the guidance above, other factors including patient preference, age, comorbidities, disease phenotype, extra-intestinal manifestations, and treatment costs need to be factored into the treatment decision. In this review we discuss current evidence in this field and provide guidance on therapeutic decision-making in clinical situations., Competing Interests: MB-A has received financial support for traveling and educational activities from or has served as an advisory board member for Pfizer, MSD, Takeda, Abbvie, Kern, Janssen, Fresenius Kabi, Biogen, Ferring, Faes Farma, Shire Pharmaceuticals, Falk Pharma, Chiesi, Gebro Pharma, Otsuka Pharmaceuticals, and Tillotts Pharma. TB has received financial support for traveling and educational activities from or has served as an advisory board member for Takeda, Janssen, and Tillotts Pharma. IB has served as an advisory board member for Pfizer, MSD, Takeda, Abbvie, Galapagos, Amgen, Arena Pharma, BMS, Janssen, Fresenius Kabi, Biogen, Ferring, Dr. Falk Pharma, and Tillotts Pharma. MC has received lecture fees and has served as advisory board member for Takeda, Janssen, Shire, MSD, Abbvie, Ferring, Fresenius, and Biogen. JM has served as a speaker, consultant or advisory board member for AbbVie, Bayer, Biogen, Bristol-Myers Squibb, Ferring, Hospira, Janssen, MSD, Otsuka, Pfizer, Sandoz, Svar, Takeda, Tillotts, and UCB, and has received grant support from AbbVie, Ferring, Fresenius Kabi, Pfizer, and Takeda. SS has received personal fees from Janssen, Takeda, Galapagos, Celltrion, Falk Pharma, Tillots pharma, Cellgene, Pfizer, and Pharmacocosmos, and has received grant support from Takeda, Abbvie, Amgen, Tillots Pharm, and Biogen., (Copyright © 2022 Marsal, Barreiro-de Acosta, Blumenstein, Cappello, Bazin and Sebastian.)
- Published
- 2022
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16. Optical biopsy mapping on endoscopic image mosaics with a marker-free probe.
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Zenteno O, Trinh DH, Treuillet S, Lucas Y, Bazin T, Lamarque D, and Daul C
- Abstract
Gastric cancer is the second leading cause of cancer-related deaths worldwide. Early diagnosis significantly increases the chances of survival; therefore, improved assisted exploration and screening techniques are necessary. Previously, we made use of an augmented multi-spectral endoscope by inserting an optical probe into the instrumentation channel. However, the limited field of view and the lack of markings left by optical biopsies on the tissue complicate the navigation and revisit of the suspect areas probed in-vivo. In this contribution two innovative tools are introduced to significantly increase the traceability and monitoring of patients in clinical practice: (i) video mosaicing to build a more comprehensive and panoramic view of large gastric areas; (ii) optical biopsy targeting and registration with the endoscopic images. The proposed optical flow-based mosaicing technique selects images that minimize texture discontinuities and is robust despite the lack of texture and illumination variations. The optical biopsy targeting is based on automatic tracking of a free-marker probe in the endoscopic view using deep learning to dynamically estimate its pose during exploration. The accuracy of pose estimation is sufficient to ensure a precise overlapping of the standard white-light color image and the hyperspectral probe image, assuming that the small target area of the organ is almost flat. This allows the mapping of all spatio-temporally tracked biopsy sites onto the panoramic mosaic. Experimental validations are carried out from videos acquired on patients in hospital. The proposed technique is purely software-based and therefore easily integrable into clinical practice. It is also generic and compatible to any imaging modality that connects to a fiberscope., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
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- 2022
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17. Author Correction: Multispectral imaging detects gastritis consistently in mouse model and in humans.
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Bazin T, Martinez-Herrera SE, Jobart-Malfait A, Benezeth Y, Boffety M, Julié C, Emile JF, Michel V, Goudail F, Touati E, Marzani F, and Lamarque D
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- 2021
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18. Multimodal imaging as optical biopsy system for gastritis diagnosis in humans, and input of the mouse model.
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Bazin T, Krebs A, Jobart-Malfait A, Camilo V, Michel V, Benezeth Y, Marzani F, Touati E, and Lamarque D
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- Adult, Aged, Animals, Female, Fluorescence, Gastritis microbiology, Gastritis pathology, Helicobacter pylori pathogenicity, Humans, Male, Mice, Mice, Inbred C57BL, Middle Aged, Multimodal Imaging instrumentation, Optical Imaging instrumentation, Video Recording methods, Gastritis diagnostic imaging, Gastroscopy methods, Multimodal Imaging methods, Optical Imaging methods
- Abstract
Background: Gastric inflammation is a major risk factor for gastric cancer. Current endoscopic methods are not able to efficiently detect and characterize gastric inflammation, leading to a sub-optimal patients' care. New non-invasive methods are needed. Reflectance mucosal light analysis is of particular interest in this context. The aim of our study was to analyze reflectance light and specific autofluorescence signals, both in humans and in a mouse model of gastritis., Methods: We recruited patients undergoing gastroendoscopic procedure during which reflectance was analysed with a multispectral camera. In parallel, the gastritis mouse model of Helicobacter pylori infection was used to investigate reflectance from ex vivo gastric samples using a spectrometer. In both cases, autofluorescence signals were measured using a confocal microscope., Findings: In gastritis patients, reflectance modifications were significant in near-infrared spectrum, with a decrease between 610 and 725 nm and an increase between 750 and 840 nm. Autofluorescence was also modified, showing variations around 550 nm of emission. In H. pylori infected mice developing gastric inflammatory lesions, we observed significant reflectance modifications 18 months after infection, with increased intensity between 617 and 672 nm. Autofluorescence was significantly modified after 1, 3 and 6 months around 550 and 630 nm. Both in human and in mouse, these reflectance data can be considered as biomarkers and accurately predicted inflammatory state., Interpretation: In this pilot study, using a practical measuring device, we identified in humans, modification of reflectance spectra in the visible spectrum and for the first time in near-infrared, associated with inflammatory gastric states. Furthermore, both in the mouse model and humans, we also observed modifications of autofluorescence associated with gastric inflammation. These innovative data pave the way to deeper validation studies on larger cohorts, for further development of an optical biopsy system to detect gastritis and finally to better surveil this important gastric cancer risk factor., Funding: The project was funded by the ANR EMMIE (ANR-15-CE17-0015) and the French Gastroenterology Society (SNFGE)., Competing Interests: Declaration of Competing Interest Authors have no conflicts of interest to declare., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2021
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19. Multispectral imaging detects gastritis consistently in mouse model and in humans.
- Author
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Bazin T, Martinez-Herrera SE, Jobart-Malfait A, Benezeth Y, Boffety M, Julié C, Emile JF, Michel V, Goudail F, Touati E, Marzani F, and Lamarque D
- Subjects
- Animals, Disease Models, Animal, Female, Gastric Mucosa diagnostic imaging, Gastric Mucosa microbiology, Gastritis diagnostic imaging, Gastritis microbiology, Helicobacter Infections microbiology, Humans, Mice, Gastric Mucosa pathology, Gastritis diagnosis, Helicobacter Infections complications, Helicobacter pylori isolation & purification, Image Processing, Computer-Assisted methods, Molecular Imaging methods
- Abstract
Gastritis constitutes the initial step of the gastric carcinogenesis process. Gastritis diagnosis is based on histological examination of biopsies. Non-invasive real-time methods to detect mucosal inflammation are needed. Tissue optical properties modify reemitted light, i.e. the proportion of light that is emitted by a tissue after stimulation by a light flux. Analysis of light reemitted by gastric tissue could predict the inflammatory state. The aim of our study was to investigate a potential association between reemitted light and gastric tissue inflammation. We used two models and three multispectral analysis methods available on the marketplace. We used a mouse model of Helicobacter pylori infection and included patients undergoing gastric endoscopy. In mice, the reemitted light was measured using a spectrometer and a multispectral camera. We also exposed patient's gastric mucosa to specific wavelengths and analyzed reemitted light. In both mouse model and humans, modifications of reemitted light were observed around 560 nm, 600 nm and 640 nm, associated with the presence of gastritis lesions. These results pave the way for the development of improved endoscopes in order to detect real-time gastritis without the need of biopsies. This would allow a better prevention of gastric cancer alongside with cost efficient endoscopies.
- Published
- 2020
- Full Text
- View/download PDF
20. Altered sleep quality is associated with Crohn's disease activity: an actimetry study.
- Author
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Bazin T, Micoulaud Franchi JA, Terras N, Taillard J, Laharie D, Zerbib F, and Philip P
- Subjects
- Actigraphy, Adult, Crohn Disease complications, Cross-Sectional Studies, Disorders of Excessive Somnolence diagnosis, Disorders of Excessive Somnolence etiology, Female, Humans, Male, Middle Aged, Prospective Studies, Sleep Wake Disorders etiology, Crohn Disease diagnosis, Crohn Disease physiopathology, Sleep Wake Disorders diagnosis
- Abstract
Background: Sleep is involved in the regulation of inflammation, healing, and digestion. The pathophysiology of Crohn's disease (CD) is unclear, and the role of sleep disturbances has recently been suggested., Objective: The present study investigated a putative association between sleep disturbances and CD activity., Methods: We conducted a prospective observational monocenter translational study, recruiting major CD patients from 2013 to 2015. Disease activity was assessed by the Harvey-Bradshaw index and the CD activity index. Objective sleep quantity and quality were measured by wrist actigraphy over a period of 7 days. The primary objective was to look for an association between wrist actigraphy parameters and CD activity., Results: Thirty-four CD patients, including 14 with active disease and 20 in remission, were included. Sleep efficiency measured by wrist actigraphy was lower in patients with active CD compared to patients in remission. Wake after sleep onset time best predicted CD activity with an AUROC of 0.83. Patients with active CD were more frequently characterized as "poor sleepers" and frequently suffered from excessive daytime sleepiness., Conclusion: Sleep efficiency is lower in patients with active CD than in those in remission. Further studies aimed at better characterizing CD patients' sleep are warranted.
- Published
- 2020
- Full Text
- View/download PDF
21. Understanding the effects of PBF process parameter interplay on Ti-6Al-4V surface properties.
- Author
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Majumdar T, Bazin T, Massahud Carvalho Ribeiro E, Frith JE, and Birbilis N
- Subjects
- Alloys, Corrosion, Hardness, Porosity, Implants, Experimental, Titanium chemistry
- Abstract
Ti-6Al-4V is commonly used in orthopaedic implants, and fabrication techniques such as Powder Bed Fusion (PBF) are becoming increasingly popular for the net-shape production of such implants, as PBF allows for complex customisation and minimal material wastage. Present research into PBF fabricated Ti-6Al-4V focuses on new design strategies (e.g. designing pores, struts or lattices) or mechanical property optimisation through process parameter control-however, it is pertinent to examine the effects of altering PBF process parameters on properties relating to bioactivity. Herein, changes in Ti-6Al-4V microstructure, mechanical properties and surface characteristics were examined as a result of varying PBF process parameters, with a view to understanding how to tune Ti-6Al-4V bio-activity during the fabrication stage itself. The interplay between various PBF laser scan speeds and laser powers influenced Ti-6Al-4V hardness, porosity, roughness and corrosion resistance, in a manner not clearly described by the commonly used volumetric energy density (VED) design variable. Key findings indicate that the relationships between PBF process parameters and ultimate Ti-6Al-4V properties are not straightforward as expected, and that wide ranges of porosity (0.03 ± 0.01% to 32.59 ± 2.72%) and corrosion resistance can be achieved through relatively minor changes in process parameters used-indicating volumetric energy density is a poor predictor of PBF Ti-6Al-4V properties. While variations in electrochemical behaviour with respect to the process parameters used in the PBF fabrication of Ti-6Al-4V have previously been reported, this study presents data regarding important surface characteristics over a large process window, reflecting the full capabilities of current PBF machinery., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
- Full Text
- View/download PDF
22. Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn's-Like Microbiota Disturbances.
- Author
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Enaud R, Hooks KB, Barre A, Barnetche T, Hubert C, Massot M, Bazin T, Clouzeau H, Bui S, Fayon M, Berger P, Lehours P, Bébéar C, Nikolski M, Lamireau T, Delhaes L, and Schaeverbeke T
- Abstract
Cystic fibrosis (CF) is a systemic genetic disease that leads to pulmonary and digestive disorders. In the majority of CF patients, the intestine is the site of chronic inflammation and microbiota disturbances. The link between gut inflammation and microbiota dysbiosis is still poorly understood. The main objective of this study was to assess gut microbiota composition in CF children depending on their intestinal inflammation. We collected fecal samples from 20 children with CF. Fecal calprotectin levels were measured and fecal microbiota was analyzed by 16S rRNA sequencing. We observed intestinal inflammation was associated with microbiota disturbances characterized mainly by increased abundances of Staphylococcus , Streptococcus, and Veillonella dispar , along with decreased abundances of Bacteroides , Bifidobacterium adolescentis , and Faecalibacterium prausnitzii . Those changes exhibited similarities with that of Crohn's disease (CD), as evidenced by the elevated CD Microbial-Dysbiosis index that we applied for the first time in CF. Furthermore, the significant over-representation of Streptococcus in children with intestinal inflammation appears to be specific to CF and raises the issue of gut-lung axis involvement. Taken together, our results provide new arguments to link gut microbiota and intestinal inflammation in CF and suggest the key role of the gut-lung axis in the CF evolution.
- Published
- 2019
- Full Text
- View/download PDF
23. Contribution of genetic amplification by PCR for the diagnosis of Helicobacter pylori infection in patients receiving proton pump inhibitors.
- Author
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Bazin T, Nchare Mfondi A, Julie C, Émile JF, Raymond J, and Lamarque D
- Abstract
Background: Helicobacter pylori detection by standard methods may be altered by proton pump inhibitor (PPI) use. However, some patients cannot or should not interrupt PPI use before undergoing testing for H. pylori . Polymerase chain reaction (PCR) could allow more reliable H. pylori detection even in patients taking PPIs., Objective: The aim of our study is to compare the H. pylori infection diagnostic value of histological examination without and with immunohistochemical staining, bacterial culture and PCR, in PPI-treated vs untreated patients., Methods: Patients undergoing a gastric endoscopy for upper digestive symptoms were included. Gastric biopsy samples were obtained. The impact of taking PPI on the diagnostic performance of the different methods was studied. PCR results were confirmed by sequencing the glmM gene., Results: A total of 497 patients were included, of whom 192 were H. pylori positive. Fifty-two patients received PPIs during the 14 days preceding the endoscopy while 140 did not. All methods had lower sensitivity than PCR, in all cases (PPI treatment or not). PPI use did not change significantly the methods' sensitivities., Conclusion: The PCR method showed the best performance for the detection of H. pylori in gastric samples, whether or not patients received previous PPI treatment. This diagnosis test could become a new gold-standard test, especially in patients undergoing PPI treatment.
- Published
- 2018
- Full Text
- View/download PDF
24. Microbiota Composition May Predict Anti-Tnf Alpha Response in Spondyloarthritis Patients: an Exploratory Study.
- Author
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Bazin T, Hooks KB, Barnetche T, Truchetet ME, Enaud R, Richez C, Dougados M, Hubert C, Barré A, Nikolski M, and Schaeverbeke T
- Subjects
- Adult, Feces microbiology, Female, Humans, Male, Treatment Outcome, Gastrointestinal Microbiome drug effects, Spondylarthritis drug therapy, Spondylarthritis microbiology, Tumor Necrosis Factor-alpha antagonists & inhibitors
- Abstract
Spondyloarthritis (SpA) pathophysiology remains largely unknown. While the association with genetic factors has been established for decades, the influence of gut microbiota is only an emerging direction of research. Despite the remarkable efficacy of anti-TNF-α treatments, non-responders are frequent and no predictive factors of patient outcome have been identified. Our objective was to investigate the modifications of intestinal microbiota composition in patients suffering from SpA three months after an anti-TNF-α treatment. We performed 16S rDNA sequencing of 38 stool samples from 19 spondyloarthritis patients before and three months after anti-TNF-α treatment onset. SpA activity was assessed at each time using ASDAS and BASDAI scores. Some modifications of the microbiota composition were observed after three months of anti-TNF-α treatment, but no specific taxon was modified, whatever the clinical response. We identified a particular taxonomic node before anti-TNF-α treatment that can predict the clinical response as a biomarker, with a higher proportion of Burkholderiales order in future responder patients. This study suggests a cross-influence between anti-TNF-α treatment and intestinal microbiota. If its results are confirmed on larger groups of patients, it may pave the way to the development of predictive tests suitable for clinical practices.
- Published
- 2018
- Full Text
- View/download PDF
25. The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis.
- Author
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Enaud R, Vandenborght LE, Coron N, Bazin T, Prevel R, Schaeverbeke T, Berger P, Fayon M, Lamireau T, and Delhaes L
- Abstract
In recent years, the gut microbiota has been considered as a full-fledged actor of the gut-brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota, forgetting the non-negligible fungal flora. In this review, we expose how the role of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research., Competing Interests: The authors declare that they have no conflict of interest.
- Published
- 2018
- Full Text
- View/download PDF
26. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis.
- Author
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Bonaz B, Bazin T, and Pellissier S
- Abstract
The microbiota, the gut, and the brain communicate through the microbiota-gut-brain axis in a bidirectional way that involves the autonomic nervous system. The vagus nerve (VN), the principal component of the parasympathetic nervous system, is a mixed nerve composed of 80% afferent and 20% efferent fibers. The VN, because of its role in interoceptive awareness, is able to sense the microbiota metabolites through its afferents, to transfer this gut information to the central nervous system where it is integrated in the central autonomic network, and then to generate an adapted or inappropriate response. A cholinergic anti-inflammatory pathway has been described through VN's fibers, which is able to dampen peripheral inflammation and to decrease intestinal permeability, thus very probably modulating microbiota composition. Stress inhibits the VN and has deleterious effects on the gastrointestinal tract and on the microbiota, and is involved in the pathophysiology of gastrointestinal disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) which are both characterized by a dysbiosis. A low vagal tone has been described in IBD and IBS patients thus favoring peripheral inflammation. Targeting the VN, for example through VN stimulation which has anti-inflammatory properties, would be of interest to restore homeostasis in the microbiota-gut-brain axis.
- Published
- 2018
- Full Text
- View/download PDF
27. Protective Microbiota: From Localized to Long-Reaching Co-Immunity.
- Author
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Chiu L, Bazin T, Truchetet ME, Schaeverbeke T, Delhaes L, and Pradeu T
- Abstract
Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance localized within a microenvironment. This review shows that the protection against pathogens also involves the mitigation of pathogenic impact without eliminating the pathogens (i.e., "disease tolerance") and the containment of microorganisms to prevent pathogenic spread. Protective microorganisms can have an impact beyond their niche, interfering with the entry, establishment, growth, and spread of pathogenic microorganisms. More fundamentally, we propose a series of conceptual clarifications in support of the idea of a "co-immunity," where an organism is protected by both its own immune system and components of its microbiota.
- Published
- 2017
- Full Text
- View/download PDF
28. Development and validation of a questionnaire assessing volitional competencies to enhance the performance of physical activities in chronic low back pain patients.
- Author
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Mathy C, Broonen JP, Henrotin Y, Marty M, Legout V, Genevay S, Duplan B, Bazin T, Laroche F, Savarieau B, and Cedraschi C
- Subjects
- Belgium, Chronic Disease, Delphi Technique, Goals, Humans, Intention, Low Back Pain physiopathology, Low Back Pain psychology, Predictive Value of Tests, Reproducibility of Results, Activities of Daily Living, Health Behavior, Health Knowledge, Attitudes, Practice, Low Back Pain diagnosis, Motivation, Research Design, Surveys and Questionnaires, Volition
- Abstract
Background: Motivation has long been emphasized as the most important determinant of action. However, there is a substantial gap between people's goals and their attainment. Patients may be motivated and yet unable to take action if their volitional competencies are insufficient. One of the important tasks of volition is goal-maintenance. Research has stressed the importance of a volitional tool, the implementation intentions. Implementation intentions indicate where, when, and how the action leading to the goal will be performed. Forming implementation intentions favours the execution of goal-directed efforts, and reinforces the relationship between intentions and behaviours. Results from various studies clearly suggest that volitional competencies and implementation intentions could play a role in low back pain (LBP) patients. However, there is at present no questionnaire allowing assessing the capacity of implementation intentions of physical activities in LBP patients., Methods/design: This study will develop such a questionnaire, using a 3-step approach. A first qualitative step to build categories and generate items; 30 patients suffering chronic LBP will be invited to participate in semi-structured interviews; verbatim and derived items will then be submitted to a panel of experts, using a Delphi method; a second quantitative step to examine the properties of items, and determine the factorial structure of the questionnaire; 100 patients suffering chronic LBP will be recruited to respond to this phase; and third, preliminary psychometric analyses (item-scale correlations, construct validity, reliability); 180 chronic LBP patients will be recruited for this phase of the study. The relationships between implementation intentions and variables affecting physical activity on chronic LBP patients, i.e. pain, physical capacities, fear-avoidance beliefs, kinesiophobia, work status, and level of physical activity will be considered., Discussion: Developing a questionnaire to assess implementation intentions would allow investigating the role of these intentions in the transition from acute to chronic LBP. The results of this study should contribute to the understanding of the psychological processes at stake in the development of chronic LBP, and in particular to the identification of factors eventually favouring patients' participation in and adherence to active physical treatments.
- Published
- 2011
- Full Text
- View/download PDF
29. Information and low back pain management: a systematic review.
- Author
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Henrotin YE, Cedraschi C, Duplan B, Bazin T, and Duquesnoy B
- Subjects
- Databases, Factual, Disease Management, Humans, Low Back Pain therapy, Low Back Pain epidemiology, Patient Education as Topic methods, Randomized Controlled Trials as Topic methods
- Abstract
Study Design: A systematic search of three electronic databases was done to identify randomized controlled trials on the effect of written or audiovisual information in low back pain., Objectives: To determine whether information is an effective preventive action and/or therapy for low back pain and which type of information is most effective., Summary of Background Data: Information is commonly used in the primary care of low back pain and mostly delivered by booklets., Methods: A systematic computer-aided search of the Medline, PsyclInfo, and Embase database. A rating system was used to assess the strength of the evidence, based on the methodologic quality of the randomized controlled trials, the relevance of the outcome measures, and the consistency of the results., Results: Eleven randomized controlled trials were selected, including seven trials of high methodologic quality, as well as one parallel group controlled survey and one longitudinal study. Only three of the seven high-quality studies showed favorable results for information. There is strong evidence that a booklet increases knowledge and moderate evidence that physician-related cues increase the confidence in a booklet and adherence to exercises. There is limited evidence that a biopsychosocial booklet is more efficient than a biomedical booklet to shift patient's beliefs about physical activity, pain, and consequences of low back trouble. There is strong evidence that booklets are not efficient on absenteeism and conflicting evidence that they are efficient on healthcare use. There is no evidence that e-mail discussion or video programs alone are effective to reduce low back pain, disability, and healthcare costs., Conclusions: Information based on a biopsychosocial model is recommended in primary care to shift patient beliefs on low back pain. Nevertheless, information delivery alone is not sufficient to prevent absenteeism and reduce healthcare costs.
- Published
- 2006
- Full Text
- View/download PDF
30. [Measurement of the variation in the thickness of lumbar disks over time in patients with lumbago].
- Author
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Vignon E, Vial B, Mathieu P, Bazin T, and Vignon G
- Subjects
- Adult, Aged, Female, Humans, Lumbar Vertebrae pathology, Male, Middle Aged, Retrospective Studies, Time Factors, Back Pain pathology, Intervertebral Disc pathology
- Abstract
The average thickness of the last 3 lumbar disks was measured using an automatic image analyzer in 53 patients who were regularly followed-up both clinically and radiographically for an average period of 14.8 years (extremes: 6 and 39 years). This retrospective study showed that disks do not necessarily become pinched with age, even in patients with lumbago, that the rate of disk pinching is extremely variable from one patient to another, that disk collapse takes an average of 20 to 30 years, that there is a correlation between the severity of the lumbago and the rate at which the disk pinches, and that there are rapidly evolutive discopathies which are responsible for severe lumbago.
- Published
- 1989
31. [Treatment of severe low back pain of disc origin using nucleorthesis].
- Author
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Vignon E, Mathieu P, Bochu M, Richard M, and Bazin T
- Subjects
- Adult, Aprotinin administration & dosage, Female, Humans, Injections, Intra-Articular, Male, Middle Aged, Prospective Studies, Radiography, Aprotinin therapeutic use, Intervertebral Disc diagnostic imaging, Intervertebral Disc Displacement drug therapy, Sciatica drug therapy
- Published
- 1989
32. Submaxillary Salivary Calculus.
- Author
-
Bazin T
- Published
- 1920
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