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8 results on '"Bazina Martinović, A."'

1. A 5-Year Follow-Up after Endovascular Treatment of 402 Intracranial Aneurysms—A Single-Centre Experience

Author

Ana Repić Buličić, David Ozretić, Marko Radoš, Josip Ljevak, Antonela Bazina Martinović, and Zdravka Poljaković Skurić

Subjects
intracranial aneurysm, rupture risk, endovascular treatment, complications, retreatment, Biology (General), QH301-705.5
Abstract

The aim of our study was to evaluate the early and long-term clinical and morphological outcomes of the endovascular treatment of ruptured and non-ruptured intracranial aneurysms in a cohort of patients from a single centre. We retrospectively analysed the treatment outcomes of 402 endovascularly treated intracranial aneurysms with an average follow-up of 5.5 years. All included patients were treated with endovascular techniques (coil, stent or both). We analysed patient demographics, risk factors for an aneurysm rupture, aneurysm characteristics, and clinical and angiographic complications and outcomes. We analysed and compared the data from the two groups, ruptured aneurysms (RAs) and unruptured aneurysms (UAs), separately. Out of the 318 patients included, a good early clinical outcome was achieved in 78.5% of RAs and in 95.3% of UAs. No complications occurred in 87.71% of patients with UAs and in 80.45% with RAs. The periprocedural rupture rate for UAs and RAs was 0.8% and 2.2%, respectively. The rate of thromboembolic events was 4.8 and 8% for UAs and RAs, respectively. A retreatment due to the recanalisation was required in 9.21% of patients with UAs and in 16.66% of patients with RAs. The results from our centre showed an overall favourable clinical outcome with acceptable periprocedural complications for both RAs and UR aneurysms and proved the endovascular method as safe and effective in the treatment of intracranial aneurysms.

Published
2024
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2. A 5-Year Follow-Up after Endovascular Treatment of 402 Intracranial Aneurysms—A Single-Centre Experience.

Author

Repić Buličić, Ana, Ozretić, David, Radoš, Marko, Ljevak, Josip, Bazina Martinović, Antonela, and Poljaković Skurić, Zdravka

Subjects
INTRACRANIAL aneurysms, ENDOVASCULAR surgery, INTRACRANIAL aneurysm ruptures, TREATMENT effectiveness, ANGIOGRAPHY, CEREBRAL angiography
Abstract

The aim of our study was to evaluate the early and long-term clinical and morphological outcomes of the endovascular treatment of ruptured and non-ruptured intracranial aneurysms in a cohort of patients from a single centre. We retrospectively analysed the treatment outcomes of 402 endovascularly treated intracranial aneurysms with an average follow-up of 5.5 years. All included patients were treated with endovascular techniques (coil, stent or both). We analysed patient demographics, risk factors for an aneurysm rupture, aneurysm characteristics, and clinical and angiographic complications and outcomes. We analysed and compared the data from the two groups, ruptured aneurysms (RAs) and unruptured aneurysms (UAs), separately. Out of the 318 patients included, a good early clinical outcome was achieved in 78.5% of RAs and in 95.3% of UAs. No complications occurred in 87.71% of patients with UAs and in 80.45% with RAs. The periprocedural rupture rate for UAs and RAs was 0.8% and 2.2%, respectively. The rate of thromboembolic events was 4.8 and 8% for UAs and RAs, respectively. A retreatment due to the recanalisation was required in 9.21% of patients with UAs and in 16.66% of patients with RAs. The results from our centre showed an overall favourable clinical outcome with acceptable periprocedural complications for both RAs and UR aneurysms and proved the endovascular method as safe and effective in the treatment of intracranial aneurysms. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Moderating effect of ppar-γ on the association of c-reactive protein and ischemic stroke in patients younger than 60

Author

I. Ćelić, K. Starčević, Dubravka Kalinić, Ivana Karmelić, Ana Merkler, M. Šimić, Zdravka Poljaković, Jadranka Sertić, and A. Bazina Martinović

Subjects
Male, medicine.medical_specialty, Genotype, Peroxisome proliferator-activated receptor, chemistry.chemical_compound, Internal medicine, Genetics, medicine, Humans, In patient, Ischemic Stroke, chemistry.chemical_classification, biology, Cholesterol, C-reactive protein, Protein level, ishemic stroke, serum CRP level, PPAG CC genotype, General Medicine, Middle Aged, PPAR gamma, Endocrinology, C-Reactive Protein, chemistry, Case-Control Studies, Ischemic stroke, biology.protein, lipids (amino acids, peptides, and proteins), Female, Body mass index
Abstract

Aim The aim of this study was to evaluate the moderating effect of peroxisome proliferator activated receptor-γ (PPAR-γ) gene variants on the association of serum C-reactive protein level (CRP) and ischemic stroke (IS). Material and methods A total of 114 patients with IS and 135 healthy controls were included. Results After adjustment for age, sex, total cholesterol, LDL and HDL cholesterol, triglycerides, hypertension, smoking, body mass index and previous therapy with antihypertensive and/or statins, PPAR-γ had statistically significant moderating effect on association of serum CRP level and IS in patients younger than 60. In participants with PPAR CG or GG genotype level of CRP and IS were not statistically significantly associated (OR = 1.00; 95% CI 0.90–1.10; p = 0.933), but in participants with PPAR CC genotype, the association of serum CRP level and IS was significant (OR = 1.67; 95% CI 1.21–2.31; p = 0.002). Conclusion In patients with PPAR CC genotype the association of serum CRP level and IS was significant.

Published
2021

6. Haptoglobin genotype 2-2 associated with atherosclerosis in patients with ischemic stroke

Author

A. Bazina Martinović, Hana Ljubić, M. Šimić, Željko Reiner, Jadranka Sertić, S. Kaštelan, Ivan Pećin, I. Miličić, Jasenka Markeljević, Livija Šimičević, Domagoj Caban, Ana Merkler, and T. Križ

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Genotype, Gastroenterology, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Stroke, Carotid atherosclerotic lesions, Hp2-2 genotype, Internal medicine, Genetics, medicine, Humans, In patient, Carotid Stenosis, Stroke, Polymorphism, Genetic, biology, Haptoglobins, business.industry, Haptoglobin, Carotid atherosclerotic lesions, Hp2-2 genotype, General Medicine, Middle Aged, medicine.disease, Atherosclerosis, Plaque, Atherosclerotic, Stenosis, 030104 developmental biology, 030220 oncology & carcinogenesis, Ischemic stroke, biology.protein, Biomarker (medicine), Female, Personalized medicine, business
Abstract

Aim Ischemic stroke (IS) is multifactorial disease and therefore different genes and proteins play a role in its development. Haptoglobin (Hp) removes free hemoglobin and protects from iron-induced oxidative damage, inflammatory response, atherosclerosis and cerebrovascular diseases. The aim of this study was to investigate Hp genetic variants in patients with carotid atherosclerotic lesions and IS. Material and methods A total of 121 subjects with IS participated in the study, 81 male and 40 female. Results Among 121 patients with IS, 79 had diffuse atherosclerotic plaques and stenosis. Hp genotype was statistically significantly associated with CDFI neck carotid artery stenosis findings (p = 0.006). Patients with Hp1-2 genotype had statistically significantly larger odds for atherosclerotic changes compared to those with Hp1-1 genotype, as well as those with Hp2-2 genotype. Conclusion This study has shown an association of the Hp2-2 genotype and atherosclerosis in patients with IS, indicating Hp2-2 genotype as a genetic biomarker for precision medicine and personalized healthcare.

Published
2020

7. Retencija urina povezana s malim dozama kvetiapina i natrijevog- valproata kod osobe starije životne dobi

Author

Kalinić, Dubravka, Bazina Martinović, Antonela, Uzun, Suzana, Kozumplik, Oliver, Lalovac, Miloš, Filipec Kanižaj, Tajana, and Mimica, Ninoslav

Subjects
kvetiapin, Na-valproat, retencija urina, starije osobe
Abstract

Kvetiapin spada u skupinu antipsihotika treće generacije, a njegov mehanizam djelovanja obuhvaća široki neurotransmitorski spektar. U usporedbi s drugim antipsihoticima rjeđe uzrokuje ekstrapiramidne nuspojave (EPS) što je od posebne važnosti prilikom primjene kod starije populacije. Usprkos povoljnom sigurnosnom profilu vezanim uz EPS, kvetiapin povećava rizik od ortostatske hipotenzije te rizik od pada. Nadalje njegov antikolinergički učinak može izazvati zadržavanje mokraće i konstipaciju. Retencija urina povezuje se s perifernim antikolinergičnim učinkom (posebno je čest pri primjeni klorpromazina, cuklopentiksola, mezoridazona i tioridazona). Prema našem saznanju do sada nije opisana retencija urina pri primjeni malih doza kvetiapina tijekom u prvim danima liječenja. Muškarac u dobi od 83 godine zaprimljen je na Zavod za biologijsku psihijatriju i psihogerijatriju putem Hitnog psihijatrijskog prijema, prezentirajući se kliničkom slikom agitiranosti u sklopu dementnog procesa. Bolesnik nije do sada psihijatrijski liječen. Heteroanamnestički se dobiju podaci kako bolesnik unatrag nekoliko godina postao zaboravljiv, smanjenog je interesa za zbivanja i ljude oko sebe, bezvoljan, sumnjičav, a unatrag nekoliko mjeseci pojačano razdražljiv, impulzivan s elementima heteroagresivnosti prema ukućanima. Psihotičnost nije bilo moguće u potpunosti isključiti. Bilježi se hod sitnim koracima uz blagi tremor ruku. Pri prijemu naprave se rutinske laboratorijske pretrage te se nađu povišene vrijednosti ureje i anemija. Nakon dolaska na Odjel ordinira se kvetiapin u dozi od 12, 5 mg/ dnevno, oksazepam u dozi u 20 mg dnevno, podijeljeno u dvije doze. Treći dan od primjene kvetiapina javlja se hipotenzija i nestabilnost prilikom hoda (što se poveže s primjenom kvetiapina) te se ukine kvetiapin, a uvede Natrijev-valproat u večernjoj dozi od 150 mg. Dva dana nakon ukidanja kvetiapina, te drugi dan nakon primjene Na- valoproata, primijeti se retencija urina koja je zahtijevala kateterizaciju. Usprkos primjeni malih doza i sporoj titraciji psihofarmaka, a poglavito pri primjeni antipsihotika kod starijih osoba potreban je dodatni oprez. Preporuča se pažljivo praćenje općeg stanja te imati na umu i nuspojave koje se inače rijetko javljaju kod ostale populacije. lako psihotični simptomi te agresivnost imaju višestruko nepovoljni učinak za opće psihofizičko stanje bolesnika, potrebno je uravnotežiti odnos koristi i rizika prilikom korištenja antipsihotika kod starijih osoba koje su posebno osjetljive za razvoj nuspojava.

Published
2019

8. Neuropsihijatrijski poremećaji kao 'nuspojave' stanja nakon moždanog udara

Author

Bazina Martinović A, Kalinić D, Starčević K

Subjects
moždani udar, nuspojave, neuropsihijatrijski poremećaji
Abstract

Kao poljedica moždanog udara javlja je niz različitih neuropsihijarijskih poremećaja. U ovome radu prikazano je koji neuropsihijatrski poremećaji se najčešće dijagnosticiraju nakon preboljelog moždanog udara kod bolesnika liječenih na KBC Zagreeb, Klinici za neurologiju.

Published
2019

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