Search

Your search keyword '"Bénet, Thomas"' showing total 285 results
Start Over Author "Bénet, Thomas"
285 results on '"Bénet, Thomas"'

5. Microorganisms Associated With Pneumonia in Children

Author

Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL) Network, Bénet, Thomas, Picot, Valentina Sánchez, Messaoudi, Mélina, Chou, Monidarin, Eap, Tekchheng, Wang, Jianwei, Shen, Kunling, Pape, Jean-William, Rouzier, Vanessa, Awasthi, Shally, Pandey, Nitin, Bavdekar, Ashish, Sanghavi, Sonali, Robinson, Annick, Rakoto-Andrianarivelo, Mala, Sylla, Maryam, Diallo, Souleymane, Nymadawa, Pagbajabyn, Naranbat, Nymadawaagiin, Russomando, Graciela, Basualdo, Wilma, Komurian-Pradel, Florence, Endtz, Hubert, Vanhems, Philippe, and Paranhos-Baccalà, Gláucia

Published
2017

16. A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation

Author

Gonzalez, Gaëlle, Bournez, Laure, Moares, Rayane Amaral, Dumarest, Marine, Galon, Clémence, Vorimore, Fabien, Cochin, Maxime, Nougairède, Antoine, Hennechart-Collette, Catherine, Perelle, Sylvie, Leparc-Goffart, Isabelle, Durand, Guillaume André, Grard, Gilda, Bénet, Thomas, Danjou, Nathalie, Blanchin, Martine, Lacour, Sandrine A., Boué, Franck, Chenut, Guillaume, Mainguet, Catherine, Simon, Catherine, Brémont, Laurence, Zientara, Stéphan, Moutailler, Sara, Martin-Latil, Sandra, Dheilly, Nolwenn M., Beck, Cécile, Lecollinet, Sylvie, Gonzalez, Gaëlle, Bournez, Laure, Moares, Rayane Amaral, Dumarest, Marine, Galon, Clémence, Vorimore, Fabien, Cochin, Maxime, Nougairède, Antoine, Hennechart-Collette, Catherine, Perelle, Sylvie, Leparc-Goffart, Isabelle, Durand, Guillaume André, Grard, Gilda, Bénet, Thomas, Danjou, Nathalie, Blanchin, Martine, Lacour, Sandrine A., Boué, Franck, Chenut, Guillaume, Mainguet, Catherine, Simon, Catherine, Brémont, Laurence, Zientara, Stéphan, Moutailler, Sara, Martin-Latil, Sandra, Dheilly, Nolwenn M., Beck, Cécile, and Lecollinet, Sylvie

Abstract

Tick-borne encephalitis virus' (TBEV) geographic range and the human incidence are increasing throughout Europe, putting a number of non-endemic regions and countries at risk of outbreaks. In spring 2020, there was an outbreak of tick-born encephalitis (TBE) in Ain, Eastern France, where the virus had never been detected before. All patients but one had consumed traditional unpasteurised raw goat cheese from a local producer. We conducted an investigation in the suspected farm using an integrative One Health approach. Our methodology included (i) the detection of virus in cheese and milk products, (ii) serological testing of all animals in the suspected farm and surrounding farms, (iii) an analysis of the landscape and localisation of wooded area, (iv) the capture of questing ticks and small mammals for virus detection and estimating enzootic hazard, and (v) virus isolation and genome sequencing. This approach allowed us to confirm the alimentary origin of the TBE outbreak and witness in real-time the seroconversion of recently exposed individuals and excretion of virus in goat milk. In addition, we identified a wooded focus area where and around which there is a risk of TBEV exposure. We provide the first TBEV isolate responsible for the first alimentary-transmitted TBE in France, obtained its full-length genome sequence, and found that it belongs to the European subtype of TBEV. TBEV is now a notifiable human disease in France, which should facilitate surveillance of its incidence and distribution throughout France.

Published
2022

18. A One-Health Approach to Investigating an Outbreak of Alimentary Tick-Borne Encephalitis in a Non-endemic Area in France (Ain, Eastern France): A Longitudinal Serological Study in Livestock, Detection in Ticks, and the First Tick-Borne Encephalitis Virus Isolation and Molecular Characterisation

Author

Gonzalez, Gaëlle, primary, Bournez, Laure, additional, Moraes, Rayane Amaral, additional, Marine, Dumarest, additional, Galon, Clémence, additional, Vorimore, Fabien, additional, Cochin, Maxime, additional, Nougairède, Antoine, additional, Hennechart-Collette, Catherine, additional, Perelle, Sylvie, additional, Leparc-Goffart, Isabelle, additional, Durand, Guillaume André, additional, Grard, Gilda, additional, Bénet, Thomas, additional, Danjou, Nathalie, additional, Blanchin, Martine, additional, Lacour, Sandrine A., additional, Franck, Boué, additional, Chenut, Guillaume, additional, Mainguet, Catherine, additional, Simon, Catherine, additional, Brémont, Laurence, additional, Zientara, Stephan, additional, Moutailler, Sara, additional, Martin-Latil, Sandra, additional, Dheilly, Nolwenn M., additional, Beck, Cécile, additional, and Lecollinet, Sylvie, additional

Published
2022
Full Text
View/download PDF

23. A one health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): a longitudinal serological study in livestock, detection in ticks, and the first TBE virus isolation and molecular characterization

Author

Gonzalez, Gaëlle, primary, Bournez, Laure, additional, Moraes, Rayane Amaral, additional, Dumarest, Marine, additional, Galon, Clémence, additional, Vorimore, Fabien, additional, Cochin, Maxime, additional, Nougairède, Antoine, additional, Hennechart-Collette, Catherine, additional, Perelle, Sylvie, additional, Leparc-Goffart, Isabelle, additional, Durand, Guillaume André, additional, Grard, Gilda, additional, Bénet, Thomas, additional, Danjou, Nathalie, additional, Blanchin, Martine, additional, Lacour, Sandrine A, additional, Boué, Franck, additional, Chenut, Guillaume, additional, Mainguet, Catherine, additional, Simon, Catherine, additional, Brémont, Laurence, additional, Zientara, Stephan, additional, Moutailler, Sara, additional, Martin-Latil, Sandra, additional, Dheilly, Nolwenn M, additional, Beck, Cécile, additional, and Lecollinet, Sylvie, additional

Published
2021
Full Text
View/download PDF

28. Cluster of Coronavirus Disease 2019 (COVID-19) in the French Alps, February 2020

Author

Danis, Kostas, Epaulard, Olivier, Bénet, Thomas, Gaymard, Alexandre, Campoy, Séphora, Botelho-Nevers, Elisabeth, Bouscambert-Duchamp, Maude, Spaccaferri, Guillaume, Ader, Florence, Mailles, Alexandra, Boudalaa, Zoubida, Tolsma, Violaine, Berra, Julien, Vaux, Sophie, Forestier, Emmanuel, Landelle, Caroline, Fougere, Erica, Thabuis, Alexandra, Berthelot, Philippe, Veil, Raphael, Levy-Bruhl, Daniel, Chidiac, Christian, Lina, Bruno, Coignard, Bruno, Saura, Christine, Brottet, Elise, Casamatta, Delphine, Gallien, Yves, George, Scarlett, Viriot, Delphine, Ait Belghiti, Fatima, Bernard-Stoecklin, Sibylle, Desenclos, Jean-Claude, Giese, Coralie, Ghislain, Didier, Gounon, Magali, Grangeret, Nathalie, Marie, Cécile, Morel, Bruno, Deher, Muriel, Ronnaux Baron, Anne-Sophie, Courbis, Geneviève, Ragozin, Nathalie, Wolska, Monika, Serange, Eric, Mercatello, Delphine, Aiouaz, Soraya, Valette, Martine, Frobert, Emilie, Josset, Laurence, Escuret, Vanessa, Morfin, Florence, Billaud, Geneviève, Blanc, Myriam, Arata-Bardet, Julie, Froidure, Marie, Le Maréchal, Marion, Pavese, Patricia, Pierre, Isabelle, Becker, Agathe, Chauvelot, Pierre, Conrad, Anne, Ferry, Tristan, Miailhes, Patrick, Perpoint, Thomas, Pouderoux, Cécile, Roux, Sandrine, Valour, Florent, Lutz, Marie-France, Pouvaret, Anne, Vitrat, Virginie, Maillet, Mylène, Janssen, Cécile, Piet, Emilie, Bosch, Alexie, Destrem, Anne-Laure, Isnard, Margaux, Challan-Belval, Thibault, Wackenheim, Chloe, Couturier, Alice, Gheno, Gael, Roupioz, Thierry, Lucet, Nicolas, Ayouni, Stéphane, Vincent, Mireille, de Epidemiología, Servicio, General de Salud Pública del Gover Balear, Dirección, Masserey Spicher, Virginie, Bourquin, Catherine, Stoll, Jeanine, Chaud, Pascal, and Mounayar, Anne-Laure

Subjects
Microbiology (medical), Pediatrics, medicine.medical_specialty, Attack rate, Pneumonia, Viral, coronavirus, Disease cluster, Asymptomatic, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, 030225 pediatrics, medicine, Major Article, Cluster Analysis, Humans, Serologic Tests, 030212 general & internal medicine, cluster, Index case, Pandemics, Aged, Retrospective Studies, Aged, 80 and over, Transmission (medicine), business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, Middle Aged, medicine.disease, infection, AcademicSubjects/MED00290, Infectious Diseases, Coinfection, Female, France, medicine.symptom, business, Coronavirus Infections, Viral load
Abstract

BackgroundOn 7 February 2020, French Health authorities were informed of a confirmed case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an Englishman infected in Singapore who had recently stayed in a chalet in the French Alps. We conducted an investigation to identify secondary cases and interrupt transmission.MethodsWe defined as a confirmed case a person linked to the chalet with a positive reverse-transcription polymerase chain reaction sample for SARS-CoV-2.ResultsThe index case stayed 4 days in the chalet with 10 English tourists and a family of 5 French residents; SARS-CoV-2 was detected in 5 individuals in France, 6 in England (including the index case), and 1 in Spain (overall attack rate in the chalet: 75%). One pediatric case, with picornavirus and influenza A coinfection, visited 3 different schools while symptomatic. One case was asymptomatic, with similar viral load as that of a symptomatic case. Seven days after the first cases were diagnosed, 1 tertiary case was detected in a symptomatic patient with from the chalet a positive endotracheal aspirate; all previous and concurrent nasopharyngeal specimens were negative. Additionally, 172 contacts were monitored; all contacts tested for SARS-CoV-2 (N = 73) were negative.ConclusionsThe occurrence in this cluster of 1 asymptomatic case with similar viral load as a symptomatic patient suggests transmission potential of asymptomatic individuals. The fact that an infected child did not transmit the disease despite close interactions within schools suggests potential different transmission dynamics in children. Finally, the dissociation between upper and lower respiratory tract results underscores the need for close monitoring of the clinical evolution of suspected cases of coronavirus disease 2019.

Published
2020
Full Text
View/download PDF

32. SupplementatyFile_TablePop_rev-leg – Supplemental material for How to save time in surveillance without losing quality: comparison of two methods of surgical site infection surveillance in orthopaedic prosthetics in a French university hospital

Author

Kuczewski, Elisabetta, Munier-Marion, Elodie, Sélilah Amour, Bénet, Thomas, Rongieras, Frédéric, Monneuse, Olivier, and Vanhems, Philippe

Subjects
111099 Nursing not elsewhere classified, 111708 Health and Community Services, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, SupplementatyFile_TablePop_rev-leg for How to save time in surveillance without losing quality: comparison of two methods of surgical site infection surveillance in orthopaedic prosthetics in a French university hospital by Elisabetta Kuczewski, Elodie Munier-Marion, Sélilah Amour, Thomas Bénet, Frédéric Rongieras, Olivier Monneuse and Philippe Vanhems in Journal of Infection Prevention

Published
2020
Full Text
View/download PDF

33. Epidemiological characteristics of cryptococcal meningoencephalitis associated with Cryptococcus neoformans var. grubii from HIV-infected patients in Madagascar: A cross-sectional study

Author

Rakotoarivelo, Rivonirina Andry, primary, Raberahona, Mihaja, additional, Rasamoelina, Tahinamandranto, additional, Rabezanahary, Andriamihaja, additional, Rakotomalala, Fetra Angelot, additional, Razafinambinintsoa, Tiana, additional, Bénet, Thomas, additional, Vanhems, Philippe, additional, Randria, Mamy Jean de Dieu, additional, Romanò, Luisa, additional, Cogliati, Massimo, additional, Cornet, Muriel, additional, and Rakoto Andrianarivelo, Mala, additional

Published
2020
Full Text
View/download PDF

35. Influenza vaccination of healthcare workers in acute-care hospitals: a case-control study of its effect on hospital-acquired influenza among patients

Author

Bénet Thomas, Régis Corinne, Voirin Nicolas, Robert Olivier, Lina Bruno, Cronenberger Silene, Comte Brigitte, Coppéré Brigitte, and Vanhems Philippe

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In acute-care hospitals, no evidence of a protective effect of healthcare worker (HCW) vaccination on hospital-acquired influenza (HAI) in patients has been documented. Our study objective was to ascertain the effectiveness of influenza vaccination of HCW on HAI among patients. Methods A nested case-control investigation was implemented in a prospective surveillance study of influenza-like illness (ILI) in a tertiary acute-care university hospital. Cases were patients with virologically-confirmed influenza occurring ≥ 72 h after admission, and controls were patients with ILI presenting during hospitalisation with negative influenza results after nasal swab testing. Four controls per case, matched per influenza season (2004-05, 2005-06 and 2006-07), were randomly selected. Univariate and multivariate conditional logistic regression models were fitted to assess factors associated with HAI among patients. Results In total, among 55 patients analysed, 11 (20%) had laboratory-confirmed HAI. The median HCW vaccination rate in the units was 36%. The median proportion of vaccinated HCW in these units was 11.5% for cases vs. 36.1% for the controls (P = 0.11); 2 (20%) cases and 21 (48%) controls were vaccinated against influenza in the current season (P = 0.16). The proportion of ≥ 35% vaccinated HCW in short-stay units appeared to protect against HAI among patients (odds ratio = 0.07; 95% confidence interval 0.005-0.98), independently of patient age, influenza season and potential influenza source in the units. Conclusions Our observational study indicates a shielding effect of more than 35% of vaccinated HCW on HAI among patients in acute-care units. Investigations, such as controlled clinical trials, are needed to validate the benefits of HCW vaccination on HAI incidence in patients.

Published
2012
Full Text
View/download PDF

36. Early-onset ventilator-associated pneumonia incidence in intensive care units: a surveillance-based study

Author

Lepape Alain, Januel Jean-Marie, Voirin Nicolas, Bénet Thomas, Vanhems Philippe, Allaouchiche Bernard, Argaud Laurent, Chassard Dominique, and Guérin Claude

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The incidence of ventilator-associated pneumonia (VAP) within the first 48 hours of intensive care unit (ICU) stay has been poorly investigated. The objective was to estimate early-onset VAP occurrence in ICUs within 48 hours after admission. Methods We analyzed data from prospective surveillance between 01/01/2001 and 31/12/2009 in 11 ICUs of Lyon hospitals (France). The inclusion criteria were: first ICU admission, not hospitalized before admission, invasive mechanical ventilation during first ICU day, free of antibiotics at admission, and ICU stay ≥ 48 hours. VAP was defined according to a national protocol. Its incidence was the number of events per 1,000 invasive mechanical ventilation-days. The Poisson regression model was fitted from day 2 (D2) to D8 to incident VAP to estimate the expected VAP incidence from D0 to D1 of ICU stay. Results Totally, 367 (10.8%) of 3,387 patients in 45,760 patient-days developed VAP within the first 9 days. The predicted cumulative VAP incidence at D0 and D1 was 5.3 (2.6-9.8) and 8.3 (6.1-11.1), respectively. The predicted cumulative VAP incidence was 23.0 (20.8-25.3) at D8. The proportion of missed VAP within 48 hours from admission was 11% (9%-17%). Conclusions Our study indicates underestimation of early-onset VAP incidence in ICUs, if only VAP occurring ≥ 48 hours are considered to be hospital-acquired. Clinicians should be encouraged to develop a strategy for early detection after ICU admission.

Published
2011
Full Text
View/download PDF

37. Incidence of Asymptomatic and Symptomatic Influenza Among Healthcare Workers: A Multicenter Prospective Cohort Study.

Author

Bénet, Thomas, Amour, Sélilah, Valette, Martine, Saadatian-Elahi, Mitra, Aho-Glélé, Ludwig Serge, Berthelot, Philippe, Denis, Marie-Agnès, Grando, Jacqueline, Landelle, Caroline, Astruc, Karine, Paris, Adeline, Pillet, Sylvie, Lina, Bruno, Vanhems, Philippe, and Group, AFP Study

Subjects
*INFLUENZA epidemiology, *RESEARCH, *ACADEMIC medical centers, *CONFIDENCE intervals, *MEDICAL personnel, *CROSS infection, *MEDICAL cooperation, *DISEASE incidence, *PSYCHOSOCIAL factors, *DESCRIPTIVE statistics, *POLYMERASE chain reaction, *LONGITUDINAL method
Abstract

Background Influenza is an important cause of viral hospital-acquired infection involving patients, healthcare workers (HCW), and visitors. The frequency of asymptomatic influenza among HCW with possible subsequent transmission is poorly described. The objective is to determine the cumulative incidence of asymptomatic, paucisymptomatic, and symptomatic influenza among HCW. Method A multicenter prospective cohort study was done in 5 French university hospitals, including 289 HCW during the 2016–2017 influenza season. HCW had 3 physical examinations (time [T] 0, before epidemic onset; T.1, before epidemic peak; T.2, T.3, after epidemic peak). A blood sample was taken each time for influenza serology and a nasal swab was collected at T1 and T2 for influenza detection by polymerase chain reaction (PCR). Positive influenza was defined as either a positive influenza PCR, and/or virus-specific seroconversion against influenza A, the only circulating virus, with no vaccination record during follow-up. Symptoms were self-reported daily between T1 and T2. Cumulative incidence of influenza was stratified by clinical presentation per 100 HCW. Results Of the 289 HCW included, 278 (96%) completed the entire follow-up. Overall, 62 HCW had evidence of influenza of whom 46.8% were asymptomatic, 41.9% were paucisymptomatic, and 11.3% were symptomatic. Cumulative influenza incidence was 22.3% (95% confidence interval [CI]: 17.4%–27.2%). Cumulative incidence of asymptomatic influenza was 5.8% (95% CI: 3.3%–9.2%), 13.7% (95% CI: 9.9%–18.2%) for paucisymptomatic influenza, and 2.9% (95% CI: 1.3%–5.5%) for symptomatic influenza. Conclusions Asymptomatic and paucisymptomatic influenza were frequent among HCW, representing 47% and 42% of the influenza burden, respectively. These findings highlight the importance of systematic implementation of infection control measures among HCW regardless of respiratory symptoms from preventing nosocomial transmission of influenza. Clinical Trials Registration NCT02868658. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

38. Additional file 1 of Comparison of the prevalence of respiratory viruses in patients with acute respiratory infections at different hospital settings in North China, 2012–2015

Author

Jianxing Yu, Zhengde Xie, Tiegang Zhang, Yanqin Lu, Hongwei Fan, Donghong Yang, Bénet, Thomas, Vanhems, Philippe, Kunling Shen, Huang, Fang, Jinxiang Han, Taisheng Li, Zhancheng Gao, Ren, Lili, and Jianwei Wang

Abstract

Table S1. Hospitals that participated in the study of acute respiratory infections in North China, 2012–2015. Table S2. Respiratory viruses detected in patients with acute respiratory infections in North China, 2012–2015, by age group and hospital setting. Figure S1. Frequency of co-infected viruses in patients with ARIs in North China, 2012–2015, by age group and hospital settings. (DOCX 391 kb)

Published
2018
Full Text
View/download PDF

39. Novel enterobacter lineage as leading cause of nosocomial outbreak involving carbapenemase-producing strains

Author

Beyrouthy, Racha, Marion, Marion, Marion, Elodie, Dananché, Cédric, Dauwalder, Olivier, Robin, Frédéric, Gauthier, Lauraine, Jousset, Agnès, Dortet, Laurent, Guérin, François, Bénet, Thomas, Cassier, Pierre, Vanhems, Philippe, Bonnet, Richard, Barets, Marion, Centre National de Référence de la Résistance aux Antibiotiques (CNR), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Pathogénie des Staphylocoques – Staphylococcal Pathogenesis (StaPath), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence Associé de la Résistance aux Antibiotiques, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory (LPE-Fondation Mérieux), Centre Léon Bérard [Lyon], INSERM, INRA, Universite Clermont Auvergne, Centre Hospitalier Universitaire de Clermont-Ferrand, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence Associé de la Résistance aux Antibiotiques [Hôpital Bicêtre AP-HP] (CNRARA/Service de Microbiologie), OUERTANI, jeannette, École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, 0301 basic medicine, Epidemiology, lcsh:Medicine, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Disease Outbreaks, Plasmid, Drug Resistance, Multiple, Bacterial, Immunologie, bacteria, Aged, 80 and over, Cross Infection, biology, Phylogenetic tree, Emerging diseases, Enterobacteriaceae Infections, Enterobacter cloacae complex, Enterobacter, Middle Aged, b-lactamase, Enterobacteriaceae, infection nosocomiale, Anti-Bacterial Agents, 3. Good health, séquence du génome, Infectious Diseases, enterobacter, Female, beta-lactamase, Novel Enterobacter Lineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains, Microbiology (medical), Lineage (genetic), 030106 microbiology, Immunology, Maladies émergentes, Gene Expression Regulation, Enzymologic, beta-Lactamases, Microbiology, lcsh:Infectious and parasitic diseases, Carbapenemase, 03 medical and health sciences, Antibiotic resistance, Enterobacter cloacae, Humans, lcsh:RC109-216, Typing, antimicrobial resistance, Aged, Research, lcsh:R, carbapenemase-producing Enterobacteriaceae, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Gene Expression Regulation, Bacterial, CPE, biology.organism_classification, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, nosocomial outbreak, 030104 developmental biology, VIM-4, next-generation sequencing, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abstract

International audience; We investigated unusual carbapenemase-producing Enterobacter cloacae complex isolates (n = 8) in the novel sequence type (ST) 873, which caused nosocomial infections in 2 hospitals in France. Whole-genome sequence typing showed the 1-year persistence of the epidemic strain, which harbored a blaVIM-4 ST1-IncHI2 plasmid, in 1 health institution and 2 closely related strains harboring blaCTX-M-15 in the other. These isolates formed a new subgroup in the E. hormaechei metacluster, according to their hsp60 sequences and phylogenomic analysis. The average nucleotide identities, specific biochemical properties, and pangenomic and functional investigations of isolates suggested isolates of a novel species that had acquired genes associated with adhesion and mobility. The emergence of this novel Enterobacter phylogenetic lineage within hospitals should be closely monitored because of its ability to persist and spread.

Published
2018
Full Text
View/download PDF

40. Investigation of the Relationships Between Clinical and Environmental Isolates ofAspergillus fumigatusby Multiple-locus Variable Number Tandem Repeat Analysis During Major Demolition Work in a French Hospital

Author

Loeffert, Sophie T, primary, Melloul, Elise, additional, Gustin, Marie-Paule, additional, Hénaff, Laetitia, additional, Guillot, Chloé, additional, Dupont, Damien, additional, Wallon, Martine, additional, Cassier, Pierre, additional, Dananché, Cédric, additional, Bénet, Thomas, additional, Botterel, Françoise, additional, Guillot, Jacques, additional, and Vanhems, Philippe, additional

Published
2018
Full Text
View/download PDF

41. NovelEnterobacterLineage as Leading Cause of Nosocomial Outbreak Involving Carbapenemase-Producing Strains

Author

Beyrouthy, Racha, primary, Barets, Marion, additional, Marion, Elodie, additional, Dananché, Cédric, additional, Dauwalder, Olivier, additional, Robin, Frédéric, additional, Gauthier, Lauraine, additional, Jousset, Agnès, additional, Dortet, Laurent, additional, Guérin, François, additional, Bénet, Thomas, additional, Cassier, Pierre, additional, Vanhems, Philippe, additional, and Bonnet, Richard, additional

Published
2018
Full Text
View/download PDF

42. Estimation of Extra Length of Stay Attributable to Hospital-Acquired Infections in Adult ICUs Using a Time-Dependent Multistate Model*

Author

Ohannessian, Robin, primary, Gustin, Marie-Paule, additional, Bénet, Thomas, additional, Gerbier-Colomban, Solweig, additional, Girard, Raphaele, additional, Argaud, Laurent, additional, Rimmelé, Thomas, additional, Guerin, Claude, additional, Bohé, Julien, additional, Piriou, Vincent, additional, and Vanhems, Philippe, additional

Published
2018
Full Text
View/download PDF

43. Performance evaluation of new automated VIDAS anti-HEV immunoassay tests

Author

Abravanel, Florence, primary, Goutagny, Nadège, additional, Lhomme, Sébastien, additional, Perret, Corinne, additional, Chenet, Mathilde, additional, Vischi, Françoise, additional, Aversenq, Alexandre, additional, Bourg, Sandrine, additional, Chapel, Aude, additional, Dehainault, Nathalie, additional, Mercier, Laurence, additional, Luciani, Françoise, additional, Pothion, Catherine, additional, Eichenlaub, Emile, additional, Bénet, Thomas, additional, Zhang, Xinxin, additional, Roques, Pierre, additional, Dugua, Jean-Marc, additional, and Izopet, Jacques, additional

Published
2018
Full Text
View/download PDF

44. Microorganisms Associated With Pneumonia in Children \textless5 Years of Age in Developing and Emerging Countries: The GABRIEL Pneumonia Multicenter, Prospective, Case-Control Study

Author

Bénet, Thomas, Sánchez Picot, Valentina, Messaoudi, Mélina, Chou, Monidarin, Eap, Tekchheng, Wang, Jianwei, Shen, Kunling, Pape, Jean-William, Rouzier, Vanessa, Awasthi, Shally, Pandey, Nitin, Bavdekar, Ashish, Sanghavi, Sonali, Robinson, Annick, Rakoto-Andrianarivelo, Mala, Sylla, Maryam, Diallo, Souleymane, Nymadawa, Pagbajabyn, Naranbat, Nymadawaagiin, Russomando, Graciela, Basualdo, Wilma, Komurian-Pradel, Florence, Endtz, Hubert, Vanhems, Philippe, Paranhos-Baccalà, Gláucia, Biological Research, Infectious diseases, (GABRIEL) Network, Epidemics, Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory (LPE-Fondation Mérieux), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), National Paediatric Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Pediatric Research Institute, Les Centres GHESKIO, Lucknow University, KEM Hospital Research Center, Centre d’Infectiologie Charles-Mérieux, Université d’Antananarivo - Madagascar, Université d'Antananarivo, Gabriel Toure Hospital [Bamako, Mali], Centre d'Infectiologie Charles Mérieux, Bamako, Mali, Mongolian Academy of Sciences (MAS), Research Institut of Health, Universidad Nacional de Asunción [Paraguay] (UNA), Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Medical Microbiology & Infectious Diseases, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Microbiology (medical), Male, medicine.medical_specialty, Mycoplasma pneumoniae, Asia, etiology, 030106 microbiology, Population, medicine.disease_cause, Mali, 03 medical and health sciences, 0302 clinical medicine, Human metapneumovirus, Internal medicine, Streptococcus pneumoniae, medicine, Pneumonia, Bacterial, Humans, 030212 general & internal medicine, Prospective Studies, education, Child, Preschool, Developing Countries, education.field_of_study, biology, business.industry, Bacterial, Infant, Pneumonia, biology.organism_classification, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Haiti, 3. Good health, respiratory tract diseases, Infectious Diseases, Child, Preschool, Case-Control Studies, Immunology, Attributable risk, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Etiology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Rhinovirus, business
Abstract

International audience; Background: Pneumonia, the leading infectious cause of child mortality globally, mainly afflicts developing countries. This prospective observational study aimed to assess the microorganisms associated with pneumonia in children aged \textless5 years in developing and emerging countries. Methods: A multicenter, case-control study by the GABRIEL (Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries) network was conducted between 2010 and 2014 in Cambodia, China, Haiti, India (2 sites), Madagascar, Mali, Mongolia, and Paraguay. Cases were hospitalized children with radiologically confirmed pneumonia; controls were children from the same setting without any features suggestive of pneumonia. Nasopharyngeal swabs were collected from all subjects; 19 viruses and 5 bacteria were identified by reverse-transcription polymerase chain reaction. Associations between microorganisms and pneumonia were quantified by calculating the adjusted population attributable fraction (aPAF) after multivariate logistic regression analysis adjusted for sex, age, time period, other pathogens, and site. Results: Overall, 888 cases and 870 controls were analyzed; >=1 microorganism was detected in respiratory samples in 93.0% of cases and 74.4% of controls (P \textless .001). Streptococcus pneumoniae, Mycoplasma pneumoniae, human metapneumovirus, rhinovirus, respiratory syncytial virus (RSV), parainfluenza virus 1, 3, and 4, and influenza virus A and B were independently associated with pneumonia; aPAF was 42.2% (95% confidence interval [CI], 35.5%-48.2%) for S. pneumoniae, 18.2% (95% CI, 17.4%-19.0%) for RSV, and 11.2% (95% CI, 7.5%-14.7%) for rhinovirus. Conclusions: Streptococcus pneumoniae, RSV, and rhinovirus may be the major microorganisms associated with pneumonia infections in children \textless5 years of age from developing and emerging countries. Increasing S. pneumoniae vaccination coverage may substantially reduce the burden of pneumonia among children in developing countries.

Published
2017
Full Text
View/download PDF

46. Comparison of the prevalence of respiratory viruses in patients with acute respiratory infections at different hospital settings in North China, 2012–2015

Author

Yu, Jianxing, primary, Xie, Zhengde, additional, Zhang, Tiegang, additional, Lu, Yanqin, additional, Fan, Hongwei, additional, Yang, Donghong, additional, Bénet, Thomas, additional, Vanhems, Philippe, additional, Shen, Kunling, additional, Huang, Fang, additional, Han, Jinxiang, additional, Li, Taisheng, additional, Gao, Zhancheng, additional, Ren, Lili, additional, and Wang, Jianwei, additional

Published
2018
Full Text
View/download PDF

48. Rapid Fatal Outcome of Cryptococcal Meningoencephalitis in a Non-HIV Immunocompromised Patient with a Low Fluconazole Susceptibility Isolate: A Case Report from Madagascar

Author

Raberahona, Mihaja, Rakotoarivelo, Rivonirina A., Randriamampionona, Njary, Rakotomalala, Angelot F., Razafinambinintsoa, Tiana, Bénet, Thomas, Vanhems, Philippe, Randria, Mamy J. D. D., Cornet, Muriel, and Rakoto-Andrianarivelo, Mala

Subjects
Article Subject
Abstract

Cryptococcal meningoencephalitis is considered rare in HIV-negative individuals. In Madagascar, the epidemiology of cryptococcosis has not yet been well described, neither in immunocompetent nor in immunocompromised patients. We report here the first Malagasy detailed case of cryptococcal meningoencephalitis in a non-HIV immunocompromised adult patient carrying a low fluconazole susceptibility isolate. We emphasize the importance of early and accurate diagnosis to meet the challenges of managing cryptococcosis in developing countries.

Published
2016
Full Text
View/download PDF

49. Incidence of surgical site infections in sub-Saharan Africa: systematic review and meta-analysis

Author

Ngaroua, Null, Ngah, Joseph Eloundou, Bénet, Thomas, Djibrilla, Yaouba, Davoine, Laure-Hélène, Hôpital Régional de Ngaoundéré [Cameroun] (HRN), Département des Sciences Biomédicales [Univ Ngaoundéré] (UN-FS), Faculté de Sciences [Univ Ngaoundéré] (UN-FS), Université de Ngaoundéré/University of Ngaoundéré [Cameroun] (UN)-Université de Ngaoundéré/University of Ngaoundéré [Cameroun] (UN), Neurochirurgie [Yaoundé, Cameroun] (Faculté de Médecine et des Sciences Biomédicales), Université de Yaoundé I, Laboratoire des pathogènes émergents -- Emerging Pathogens Laboratory (LPE-Fondation Mérieux), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Surgical Procedures, Sub-Saharan Africa, [SDV.IMM] Life Sciences [q-bio]/Immunology, Incidence, Operative Time, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Operative, Risk Factors, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Humans, Surgical Wound Infection, [SDV.IMM]Life Sciences [q-bio]/Immunology, Surgical site infections, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Developing Countries, Africa South of the Sahara
Abstract

International audience; INTRODUCTION: Surgical Site Infections (SSI) cause morbi-mortality and additional healthcare expenditures. Developing countries are the most affected. The objective was to estimate the pooled incidence of SSI in Sub-Saharan Africa and describe its major risk factors. METHODS: Systematic review and meta-analysis were conducted using the databases of the World Health Organization Regional Office for Africa, PubMed and standard search to select electronic articles published between 2006 and 2015. Only articles investigating SSI impact and risk factors in Sub-Saharan African countries were retained. RESULTS: Out of 95 articles found, 11 met the inclusion criteria. Only 9 countries out of 45 have contributed, with a huge amount of information coming from Nigeria (5 articles out of 11). The impact of SSI ranged from 6.8% to 26% with predominance in general surgery. The pooled incidence of SSI was 14.8% (95% CI: 15,5-16,2%) with significant heterogeneity according to the specialty and the method of monitoring. Most cited risk factors were long procedure length and categories 3 and 4 of Altemeier contamination class. Other factors included hospital environment, inadequate care practices and underlying pathologies. CONCLUSION: SSI incidence is high in Sub-Saharan Africa. Studies in this area could improve knowledge, prevention and control of these multiple risk factors.

Published
2016
Full Text
View/download PDF

50. Monitoring of clinical strains and environmental fungal aerocontamination to prevent invasive aspergillosis infections in hospital during large deconstruction work: a protocol study

Author

Loeffert, Sophie Tiphaine, primary, Melloul, Elise, additional, Dananché, Cédric, additional, Hénaff, Laetitia, additional, Bénet, Thomas, additional, Cassier, Pierre, additional, Dupont, Damien, additional, Guillot, Jacques, additional, Botterel, Françoise, additional, Wallon, Martine, additional, Gustin, Marie-Paule, additional, and Vanhems, Philippe, additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results