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17 results on '"Bearss, Jeremy J."'

2. Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

Author

Bell, Todd M., primary, Facemire, Paul, additional, Bearss, Jeremy J., additional, Raymond, Jo Lynne, additional, Chapman, Jennifer, additional, Zeng, Xiankun, additional, Shamblin, Joshua D., additional, Williams, Janice A., additional, Grosenbach, Douglas W., additional, Hruby, Dennis E., additional, Damon, Inger K., additional, Goff, Arthur J., additional, and Mucker, Eric M., additional

Published
2024
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3. Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Author

Amemiya, Kei, Dankmeyer, Jennifer L., Bearss, Jeremy J., Zeng, Xiankun, Stonier, Spencer W., Soffler, Carl, Cote, Christopher K., Welkos, Susan L., Fetterer, David P., Chance, Taylor B., Trevino, Sylvia R., Worsham, Patricia L., and Waag, David M.

Published
2020
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5. Intensive Care Unit–Like Care of Nonhuman Primates with Ebola Virus Disease

Author

Blair, Paul W, primary, Kortepeter, Mark G, additional, Downey, Lydia G, additional, Madar, Cristian S, additional, Downs, Isaac L, additional, Martins, Karen A, additional, Rossi, Franco, additional, Williams, Janice A, additional, Madar, Annie, additional, Schellhase, Christopher W, additional, Bearss, Jeremy J, additional, Zeng, Xiankun, additional, Bavari, Sina, additional, Soloveva, Veronica, additional, Wells, Jay B, additional, Stuthman, Kelly S, additional, Garza, Nicole L, additional, Vantongeren, Sean A, additional, Donnelly, Ginger C, additional, Steffens, Jesse, additional, Kalapaca, Jennifer, additional, Wiseman, Perry, additional, Henry, Joseph, additional, Marko, Shannon, additional, Chappell, Mark, additional, Lugo-Roman, Luis, additional, Ramos-Rivera, Elliot, additional, Hofer, Christian, additional, Blue, Eugene, additional, Moore, Joshua, additional, Fiallos, Jimmy, additional, Wetzel, Darrel, additional, Pratt, William D, additional, Unangst, Tami, additional, Miller, Adele, additional, Sola, James J, additional, Reisler, Ronald B, additional, and Cardile, Anthony P, additional

Published
2020
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7. Intensive Care Unit-Like Care of Nonhuman Primates with Ebola Virus Disease.

Author

Blair, Paul W, Kortepeter, Mark G, Downey, Lydia G, Madar, Cristian S, Downs, Isaac L, Martins, Karen A, Rossi, Franco, Williams, Janice A, Madar, Annie, Schellhase, Christopher W, Bearss, Jeremy J, Zeng, Xiankun, Bavari, Sina, Soloveva, Veronica, Wells, Jay B, Stuthman, Kelly S, Garza, Nicole L, Vantongeren, Sean A, Donnelly, Ginger C, and Steffens, Jesse

Subjects
EBOLA virus disease, CRITICAL care medicine, EBOLA virus, INTENSIVE care units, PRIMATES
Abstract

Background: Ebola virus disease (EVD) supportive care strategies are largely guided by retrospective observational research. This study investigated the effect of EVD supportive care algorithms on duration of survival in a controlled nonhuman primate (NHP) model.Methods: Fourteen rhesus macaques were challenged intramuscularly with a target dose of Ebola virus (1000 plaque-forming units; Kikwit). NHPs were allocated to intensive care unit (ICU)-like algorithms (n = 7), intravenous fluids plus levofloxacin (n = 2), or a control group (n = 5). The primary outcome measure was duration of survival, and secondary outcomes included changes in clinical laboratory values.Results: Duration of survival was not significantly different between the pooled ICU-like algorithm and control groups (8.2 vs 6.9 days of survival; hazard ratio; 0.50; P = .25). Norepinephrine was effective in transiently maintaining baseline blood pressure. NHPs treated with ICU-like algorithms had delayed onset of liver and kidney injury.Conclusions: While an obvious survival difference was not observed with ICU-like care, clinical observations from this model may aid in EVD supportive care NHP model refinement. [ABSTRACT FROM AUTHOR]

Published
2021
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9. Persistent Marburg Virus Infection in the Testes of Nonhuman Primate Survivors

Author

Coffin, Kayla M., primary, Liu, Jun, additional, Warren, Travis K., additional, Blancett, Candace D., additional, Kuehl, Kathleen A., additional, Nichols, Donald K., additional, Bearss, Jeremy J., additional, Schellhase, Christopher W., additional, Retterer, Cary J., additional, Weidner, Jessica M., additional, Radoshitzky, Sheli R., additional, Brannan, Jennifer M., additional, Cardile, Anthony P., additional, Dye, John M., additional, Palacios, Gustavo, additional, Sun, Mei G., additional, Kuhn, Jens H., additional, Bavari, Sina, additional, and Zeng, Xiankun, additional

Published
2018
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11. A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever

Author

Cashman, Kathleen A., primary, Wilkinson, Eric R., additional, Shaia, Carl I., additional, Facemire, Paul R., additional, Bell, Todd M., additional, Bearss, Jeremy J., additional, Shamblin, Joshua D., additional, Wollen, Suzanne E., additional, Broderick, Kate E., additional, Sardesai, Niranjan Y., additional, and Schmaljohn, Connie S., additional

Published
2017
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12. Identification and pathological characterization of persistent asymptomatic Ebola virus infection in rhesus monkeys

Author

Zeng, Xiankun, primary, Blancett, Candace D., additional, Koistinen, Keith A., additional, Schellhase, Christopher W., additional, Bearss, Jeremy J., additional, Radoshitzky, Sheli R., additional, Honnold, Shelley P., additional, Chance, Taylor B., additional, Warren, Travis K., additional, Froude, Jeffrey W., additional, Cashman, Kathleen A., additional, Dye, John M., additional, Bavari, Sina, additional, Palacios, Gustavo, additional, Kuhn, Jens H., additional, and Sun, Mei G., additional

Published
2017
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14. Characterization of pathogenesis of and immune response to Burkholderia pseudomallei K96243 using both inhalational and intraperitoneal infection models in BALB/c and C57BL/6 mice

Author

Bearss, Jeremy J., primary, Hunter, Melissa, additional, Dankmeyer, Jennifer L., additional, Fritts, Kristen A., additional, Klimko, Christopher P., additional, Weaver, Chris H., additional, Shoe, Jennifer L., additional, Quirk, Avery V., additional, Toothman, Ronald G., additional, Webster, Wendy M., additional, Fetterer, David P., additional, Bozue, Joel A., additional, Worsham, Patricia L., additional, Welkos, Susan L., additional, Amemiya, Kei, additional, and Cote, Christopher K., additional

Published
2017
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15. Characterization of Burkholderia pseudomallei Strains Using a Murine Intraperitoneal Infection Model and In Vitro Macrophage Assays

Author

Welkos, Susan L., primary, Klimko, Christopher P., additional, Kern, Steven J., additional, Bearss, Jeremy J., additional, Bozue, Joel A., additional, Bernhards, Robert C., additional, Trevino, Sylvia R., additional, Waag, David M., additional, Amemiya, Kei, additional, Worsham, Patricia L., additional, and Cote, Christopher K., additional

Published
2015
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16. Ebola Virus Infections in Nonhuman Primates Are Temporally Influenced by Glycoprotein Poly-U Editing Site Populations in the Exposure Material.

Author

Trefry, John C., Wollen, Suzanne E., Nasar, Farooq, Shamblin, Joshua D., Kern, Steven J., Bearss, Jeremy J., Jefferson, Michelle A., Chance, Taylor B., Kugelman, Jeffery R., Ladner, Jason T., Honko, Anna N., Kobs, Dean J., Wending, Morgan Q. S., Sabourin, Carol L., Pratt, William D., Palacios, Gustavo F., and Pitt, M. Louise M.

Subjects
EBOLA virus, EBOLA virus disease, GLYCOPROTEINS, FILOVIRIDAE, RNA editing
Abstract

Recent experimentation with the variants of the Ebola virus that differ in the glycoprotein's poly-uridine site, which dictates the form of glycoprotein produced through a transcriptional stutter, has resulted in questions regarding the pathogenicity and lethality of the stocks used to develop products currently undergoing human clinical trials to combat the disease. In order to address these concerns and prevent the delay of these critical research programs, we designed an experiment that permitted us to intramuscularly challenge statistically significant numbers of naïve and vaccinated cynomolgus macaques with either a 7U or 8U variant of the Ebola virus, Kikwit isolate. In naïve animals, no difference in survivorship was observed; however, there was a significant delay in the disease course between the two groups. Significant differences were also observed in time-of-fever, serum chemistry, and hematology. In vaccinated animals, there was no statistical difference in survivorship between either challenge groups, with two succumbing in the 7U group compared to 1 in the 8U challenge group. In summary, survivorship was not affected, but the Ebola virus disease course in nonhuman primates is temporally influenced by glycoprotein poly-U editing site populations. [ABSTRACT FROM AUTHOR]

Published
2015
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17. Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates.

Author

Reisler, Ronald B., Zeng, Xiankun, Schellhase, Christopher W., Bearss, Jeremy J., Warren, Travis K., Trefry, John C., Christopher, George W., Kortepeter, Mark G., Bavari, Sina, and Cardile, Anthony P.

Subjects
EBOLA virus disease, EPIDEMICS, BACTERIAL diseases, GASTROINTESTINAL system, ANTIBIOTICS
Abstract

In the 2014–2016 West Africa Ebola Virus (EBOV) outbreak, there was a significant concern raised about the potential for secondary bacterial infection originating from the gastrointestinal tract, which led to the empiric treatment of many patients with antibiotics. This retrospective pathology case series summarizes the gastrointestinal pathology observed in control animals in the rhesus EBOV-Kikwit intramuscular 1000 plaque forming unit infection model. All 31 Non-human primates (NHPs) exhibited lymphoid depletion of gut-associated lymphoid tissue (GALT) but the severity and the specific location of the depletion varied. Mesenteric lymphoid depletion and necrosis were present in 87% (27/31) of NHPs. There was mucosal barrier disruption of the intestinal tract with mucosal necrosis and/or ulceration most notably in the duodenum (16%), cecum (16%), and colon (29%). In the intestinal tract, hemorrhage was noted most frequently in the duodenum (52%) and colon (45%). There were focal areas of bacterial submucosal invasion in the gastrointestinal (GI) tract in 9/31 (29%) of NHPs. Only 2/31 (6%) had evidence of pancreatic necrosis. One NHP (3%) experienced jejunal intussusception which may have been directly related to EBOV. Immunofluorescence assays demonstrated EBOV antigen in CD68+ macrophage/monocytes and endothelial cells in areas of GI vascular injury or necrosis. [ABSTRACT FROM AUTHOR]

Published
2018
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