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1. Prevalencia de enfermedades reumáticas en población adulta en España (estudio EPISER 2016). Objetivos y metodología

Author

Noemí Navarro Ricos, María José Moreno Martínez, Teresa Font Gayá, Boris Anthony Blanco Caceres, Fernando Pérez Ruiz, Deseada Palma Sánchez, José M. Pego-Reigosa, Antonio Juan-Mas, Neus Quilis Martí, Francisca Sivera, Jordi Pons Dolset, Marta Mayor González, Daniel Seoane-Mato, Inmaculada Paniagua Zudaire, Federico Díaz-González, Alejandro Olivé, Antonio Romero Pérez, Ana Cruz Valenciano, Anahy Brandy García, Mónica Sánchez, Joana Atxotegi Sáenz de Buruaga, Francisco J. Blanco, Lucía Silva-Fernández, Miguel Ángel Polo Ostariz, Fermín Medina Varo, Cristina Macía Villa, Fred Antón-Pagés, Simón Ángel Sánchez-Fernández, Paula Rubio Muñoz, Eugenio Chamizo, Natividad del Val del Amo, Eduard Graell Martín, María del Mar Ruiz Tudela, Beatriz González Alvarez, Luisa Marena Rojas Vargas, Javier Narváez, Mercedes Morcillo Valle, Carlos Sánchez-Piedra, Paula Virginia García Morales, Gustavo Añez Sturchio, Dolores Fábregas Canales, María Luisa González Gómez, Irati Urionagüena Onaindia, Carolina Bordoy Ferrer, Cristina Martínez Dubois, Raúl Cortés Verdú, Laura Hernández, Víctor Quevedo Vila, Fatima Álvarez Reyes, Javier Ballina, Marta Larrosa, Sara Rojas Herrera, Lara M. Chaves Chaparro, Sagrario Bustabad, Susana Ruiz-Alejos Garrido, and Laura Garrido Courel

Subjects
medicine.medical_specialty, Rheumatology, business.industry, Adult population, medicine, business, Humanities, Surgery
Abstract

Resumen Objetivos Describir la metodologia del estudio de prevalencia de las enfermedades reumaticas en la poblacion adulta en Espana, EPISER 2016, asi como sus fortalezas y limitaciones. El objetivo del proyecto es estimar la prevalencia de artritis reumatoide (AR), artropatia psoriasica (APs), espondilitis anquilosante (EA), lupus eritematoso sistemico (LES), sindrome de Sjogren (SS), artrosis (de rodilla, cadera, manos, columna cervical y lumbar), fibromialgia, gota y fractura osteoporotica clinica. Material y metodo Estudio transversal multicentrico de base poblacional en el que participan 45 municipios de las 17 comunidades autonomas. La poblacion de referencia esta compuesta por adultos de 20 o mas anos residentes en Espana. La recogida de informacion se llevara a cabo mediante encuesta telefonica empleando el sistema Computer Assisted Telephone Interview (CATI). Las sospechas diagnosticas y los diagnosticos autorreferidos seran estudiadas por reumatologos del hospital de referencia de los municipios seleccionados. Analisis estadistico: se calcularan las prevalencias de enfermedades reumaticas mediante estimadores y sus IC del 95%. Se calcularan factores de ponderacion en funcion de la probabilidad de seleccion en cada una de las etapas del muestreo. Se tendra en cuenta la distribucion de la poblacion en Espana segun datos del Instituto Nacional de Estadistica. Conclusiones Los cambios sociodemograficos y en habitos de vida durante los ultimos 16 anos justifican la realizacion de EPISER 2016. El estudio ofrecera datos actualizados de prevalencia en AR, EA, APs, LES, SS, artrosis, fibromialgia, gota y fractura osteoporotica clinica. Los resultados permitiran comparar los datos con estudios de otros paises y con el EPISER 2000.

Published
2019
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2. Novel risk loci for COVID-19 hospitalization among admixed American populations

Author

Silvia Diz-de Almeida, Raquel Cruz, Andre D Luchessi, José M Lorenzo-Salazar, Miguel López de Heredia, Inés Quintela, Rafaela González-Montelongo, Vivian Nogueira Silbiger, Marta Sevilla Porras, Jair Antonio Tenorio Castaño, Julian Nevado, Jose María Aguado, Carlos Aguilar, Sergio Aguilera-Albesa, Virginia Almadana, Berta Almoguera, Nuria Alvarez, Álvaro Andreu-Bernabeu, Eunate Arana-Arri, Celso Arango, María J Arranz, Maria-Jesus Artiga, Raúl C Baptista-Rosas, María Barreda- Sánchez, Moncef Belhassen-Garcia, Joao F Bezerra, Marcos AC Bezerra, Lucía Boix-Palop, María Brion, Ramón Brugada, Matilde Bustos, Enrique J Calderón, Cristina Carbonell, Luis Castano, Jose E Castelao, Rosa Conde-Vicente, M Lourdes Cordero-Lorenzana, Jose L Cortes-Sanchez, Marta Corton, M Teresa Darnaude, Alba De Martino-Rodríguez, Victor del Campo-Pérez, Aranzazu Diaz de Bustamante, Elena Domínguez-Garrido, Rocío Eirós, María Carmen Fariñas, María J Fernandez-Nestosa, Uxía Fernández-Robelo, Amanda Fernández-Rodríguez, Tania Fernández-Villa, Manuela Gago-Dominguez, Belén Gil-Fournier, Javier Gómez-Arrue, Beatriz González Álvarez, Fernan Gonzalez Bernaldo de Quirós, Anna González-Neira, Javier González-Peñas, Juan F Gutiérrez-Bautista, María José Herrero, Antonio Herrero-Gonzalez, María A Jimenez-Sousa, María Claudia Lattig, Anabel Liger Borja, Rosario Lopez-Rodriguez, Esther Mancebo, Caridad Martín-López, Vicente Martín, Oscar Martinez-Nieto, Iciar Martinez-Lopez, Michel F Martinez-Resendez, Angel Martinez-Perez, Juliana F Mazzeu, Eleuterio Merayo Macías, Pablo Minguez, Victor Moreno Cuerda, Silviene F Oliveira, Eva Ortega-Paino, Mara Parellada, Estela Paz-Artal, Ney PC Santos, Patricia Pérez-Matute, Patricia Perez, M Elena Pérez-Tomás, Teresa Perucho, Mellina Pinsach-Abuin, Guillermo Pita, Ericka N Pompa-Mera, Gloria L Porras-Hurtado, Aurora Pujol, Soraya Ramiro León, Salvador Resino, Marianne R Fernandes, Emilio Rodríguez-Ruiz, Fernando Rodriguez-Artalejo, José A Rodriguez-Garcia, Francisco Ruiz-Cabello, Javier Ruiz-Hornillos, Pablo Ryan, José Manuel Soria, Juan Carlos Souto, Eduardo Tamayo, Alvaro Tamayo-Velasco, Juan Carlos Taracido-Fernandez, Alejandro Teper, Lilian Torres-Tobar, Miguel Urioste, Juan Valencia-Ramos, Zuleima Yáñez, Ruth Zarate, Itziar de Rojas, Agustín Ruiz, Pascual Sánchez, Luis Miguel Real, SCOURGE Cohort Group, Encarna Guillen-Navarro, Carmen Ayuso, Esteban Parra, José A Riancho, Augusto Rojas-Martinez, Carlos Flores, Pablo Lapunzina, and Ángel Carracedo

Subjects
GWAS, COVID-19, SNP, Medicine, Science, Biology (General), QH301-705.5
Abstract

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.

Published
2024
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3. Use of risk chart algorithms for the identification of psoriatic arthritis patients at high risk for cardiovascular disease: findings derived from the project CARMA cohort after a 7.5-year follow-up period

Author

Jesús Tornero, Alba Erra, Santos Castañeda, Carolina Pérez-García, Raimon Sanmartí, Sara Marsal, Ingrid Moller, Esperanza Naredo, Miguel A González-Gay, Celia Erausquin, Ivan Castellví, Javier Llorca, Alejandro Muñoz, María Galindo, Enrique Raya, Lydia Abasolo, Gema Bonilla, Alfonso Corrales, Inmaculada Ureña, Carlos Rodríguez-Lozano, Carlos González-Juanatey, Cristina Fernandez Carballido, Francisco J López-Longo, Miguel Ángel González-Gay, Eduardo Collantes, José A Miranda-Filloy, Sagrario Bustabad, Indalecio Monteagudo, Jose A Piqueras, Tatiana Cobo, Joan Maymó, Carmen Barbadillo, Soledad Ojeda, Jaime Calvo Alen, Antonio Fernandez Nebro, Isabel Rodríguez, Pilar Font, Martina Steiner, Eugenio Chamizo Carmona, Beatriz González Álvarez, Santiago Munoz, Joan M Nolla, Fernando Sánchez-Alonso, Julio Sanchez, Raul Menor Almagro, Ana Pérez Gómez, Monica Ibañez, Elena Heras-Recuero, Trinidad Pérez Sandoval, Miren Uriarte-Ecenarro, Angela Pecondón, Hye Sang Park, Jessica Polo y La Borda, Zulema Plaza, Carmen García Gómez, Ivan Ferraz-Amaro, Jesús Tomás Sanchez-Costa, Olga Carmen Sánchez-González, Ana Isabel Turrión-Nieves, Ana Perez-Alcalá, José L FernándezSueiro, José A Pinto-Tasende, Eugenia Gonzálezde Rábago, María J González-Fernández, Ramón Huguet Codina, Beatriz Yoldi, Mercedes Ramentol, Gabriela Ávila, Cayetano Alegre, Fernando Gamero, José García Torón, María P Moreno-Gil, Antonio Juan-Mas, Pilar Espiño, Inmaculada Ros, Horacio Berman, Oscar Fontseré Patón, Benjamín Fernández Gutiérrez, José M Pina-Salvador, María D Fábregas, Montserrat Romera, Jesús A García-Vadillo, Rosario García de Vicuña, María A Belmonte, María V Irigoyen, Olga Martínez González, Rebeca Belmonte Gómez, Pastora Granados Bautista, Azucena Hernández Sanz, José Santos Rey, Carmen O Sánchez-González, Javier Bachiller, Antonio Zea, Francisco J Manero, Chesús Beltrán Audera, Marta Medrano, Jesús Babío Herráez, Javier del Pino, Ruth López González, María Enriqueta Peiró, José M Senabre, José C Rosas, Isabel Rotés, Estefanía Moreno, Javier Calvo, Amalia Rueda, Pilar Morales, Ana Nieto, Ana Ruibal Escribano, Sergio Ros Expósito, Ginés Sánchez Nievas, Enrique Júdez Navarro, Manuela Sianes Fernández, Silvia Martínez Pardo, Manel Pujol, Alberto Cantabrana, Esmeralda Delgado, Sergio Rodríguez Montero, Javier Rivera Redondo, Teresa González Hernández, Francisco J González-Polo, José M Moreno, Emilio Giner Serret, Laura Cebrián Méndez, María Teresa Navío, Teresa Pedraz Penalva, Encarnación Pagán, Pablo Mesadel Castillo, Ana Cruz, Ana Turrión, Desireé Ruíz, Antonio López Meseguer, Manuel J Moreno, Luis F Linares, Mercedes Morcillo, María L González-Gómez, José M Aramburu, Natalia A Rivera, Olaia Fernández Berrizbeitia, Manel Riera, Yolanda María León, Miriam Amirall, Jordi Fiter, Julia Fernández Melón, Luis Espadaler, Joaquín Belzunegui, Inmaculada Bañegil, César Díaz, Ramón Valls, María Bonet, Eva Revuelta Evrard, Javier R Godo, and José A González-Fernández

Subjects
Medicine
Abstract

Objective To assess the predictive value of four cardiovascular (CV) risk algorithms for identifying high-risk psoriatic arthritis (PsA) patients.Methods Evaluation of patients with PsA enrolled in the Spanish prospective project CARdiovascular in RheuMAtology. Baseline data of 669 PsA patients with no history of CV events at the baseline visit, who were followed in rheumatology outpatient clinics at tertiary centres for 7.5 years, were retrospectively analysed to test the performance of the Systematic Coronary Risk Assessment (SCORE), the modified version (mSCORE) European Alliance of Rheumatology Associations (EULAR) 2015/2016, the SCORE2 algorithm (the updated and improved version of SCORE) and the QRESEARCH risk estimator version 3 (QRISK3).Results Over 4790 years of follow-up, there were 34 CV events, resulting in a linearised rate of 7.10 per 1000 person-years (95% CI 4.92 to 9.92). The four CV risk scales showed strong correlations and all showed significant associations with CV events (p

Published
2024
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4. Lipoprotein(A) Concentrations In Rheumatoid Arthritis On Biologic Therapy: Results From The Cardiovascular In Rheumatology [Carma] Study Project

Author

Manuela Sianes Fernández, Pablo Mesa del Castillo, Mercedes Morcillo, Isabel Labiano Bastero, Emilio Giner Serret, Javier del Pino, Cesar magro, Javier Rivera Redondo, Esperanza Naredo, Ramón Huguet Codina, María D. Fábregas, Daniel Pielfort Garrido, Beatriz González Alvarez, José M. Aramburu, Luis María Jiménez, Jose Gonzalez, Eduardo Collantes, Beatriz Yoldi, César Díaz, Enrique Júdez Navarro, Encarnación Pagán, Ivan Castellví, Javier R. Godo, José Santos-Rey, Antonio Fernández Nebro, Joan Maymó, María Luz García Vivar, Fernando Jimenez Zorzo, Raimon Sanmartí, Olga Martínez-González, Mercedes Ramentol, Claudia Murillo, Sergio Antonio Rodríguez Montero, Javier Calvo, Javier Llorca, Jordi Fiter, Chesús Beltrán Audera, Cayetano Alegre De Miquel, Gabriela Ávila, Antonio López Meseguer, Jaime Calvo Alen, Rosario García de Vicuña, Miriam García Arias, Marta Medrano, Joan M. Nolla, Trinidad Pérez Sandoval, G Salvador, Sagrario Bustabad, José Antonio Pinto-Tasende, María José Galindo, Eugenio Chamizo-Carmona, José García Torón, Ma Dolores Beteta Fernández, Ramón Valls, María A. Martín-Martínez, Pilar Morales, Francisco J. Blanco García, José M. Moreno, Teresa González Hernández, María Ángeles García Morales, Laura Cebrián Méndez, Antonio Atanes Sandoval, Isabel Rotés, Javier García González, Félix Francisco, Isabel Mateo, Indalecio Monteagudo, Maria Angeles Belmonte López, Manel Pujol, Estefanía Quesada-Masachs, Inmaculada Ros, Fernando Sánchez-Alonso, Ma José Moreno Martínez, Santos Castañeda, Ana Turrión, Juan Carlos Quevedo, Federico Díaz-González, Ruth López González, Estefanía Moreno, Esmeralda Delgado, Ana Ruibal Escribano, Carlos González-Juanatey, Sergio Ros Expósito, Pilar Font, Cristina Fernández Carballido, Francisco J. González Polo, Francisco J. López Longo, Alba Erra, Tatiana Cobo-Ibáñez, Carmen O. Sánchez González, Jesús Alberto García Vadillo, Olga Maiz, Montserrat Romera-Baurés, Gloria García Consuegra, Carmen Barbadillo, Virginia Ruiz, María Bonet, Jesús Babío Herráez, Dolores Fábregas-Canales, Antonio J. Mas, Ana Cruz, Miren Uriarte-Ecenarro, M.V. Irigoyen, Sara Marsal Barril, I. Ureña, Yolanda María León, Oscar Fontseré Patón, Alejandro Muñoz, Ángela Pecondón, Javier Bachiller, Pilar Espiño, Eva Revuelta Evrard, Miriam Amirall, Luis F. Linares, María Dolores Sánchez González, Ana Nieto, Benjamín Fernández Gutiérrez, Martina Steiner, Sara Manrique-Arija, María Luisa González Gómez, Carlos González Fernández, Inmaculada Bañegil, Dolors Grado, María J. González Fernández, Carlos Rodríguez Lozano, Cruz Fernández Espartero, Ingrid Möller, Eugenia Gonzalez de Rábago, Amalia Rueda, María P. Moreno Gil, Luis Espadaler, María Pilar Lis Bona, Inmaculada Jiménez, Julia Fernández Melón, Eugenio Giménez Ubeda, Isabel Rodríguez, C. Erausquin, Natividad Oreiro Villar, Raúl Menor Almagro, Rebeca Belmonte Gómez, Jesús Tornero-Molina, Ángel María García Aparicio, Horacio Berman, Enrique Raya, María Teresa Navío, Francisco J. Manero, Silvia Martínez Pardo, Joaquín Belzunegui, José M. Senabre, Manel Riera, Julio Sánchez, María Enriqueta Peiró, Jesús Marzo Gracía, Mónica Ibáñez, Natalia A. Rivera, J. Carlos Fernández López, Santiago Muñoz, Carmen García-Gómez, José C. Rosas, Ginés Sánchez Nievas, Elena Alonso Blanco Morales, Alberto Cantabrana, Manuel J. Moreno, Soledad Ojeda, Silvia Iniesta Escolano, Desireé Ruíz, Gema Bonilla, Antonio Zea, Carla Lannuzzelli Barroso, Pastora Granados Bautista, Luis Carreño, Francisco J. Navarro Blasco, José A. Piqueras, José A. Miranda-Filloy, Sonia Cabrera, Lydia Abasolo, Natalia Palmou, Virginia Coret Cagigal, Estefania Moreno Ruzafa, Alfonso Corrales, Silvia Sánchez Serrano, Delia Gerona, Miguel A. González-Gay, Elena Riera Alonso, Juana Sampedro Alvarez, Fernando Gamero, Azucena Hernández Sanz, Olaia Fernández Berrizbeitia, and Universidad de Cantabria

Subjects
Adult, Male, Risk, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Inflammatory arthritis, 030204 cardiovascular system & hematology, Biologics, Gastroenterology, Arthritis, Rheumatoid, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Tocilizumab, Internal medicine, Internal Medicine, medicine, Outpatient clinic, Humans, Rheumatoid arthritis, 030203 arthritis & rheumatology, Nutrition and Dietetics, biology, business.industry, Abatacept, Confounding, Lipoprotein(a), Middle Aged, medicine.disease, Cardiovascular disease, Rheumatology, Biological Therapy, Cross-Sectional Studies, chemistry, Immunology, biology.protein, Female, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Background Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate the impact of biologic therapies (BT) on Lp(a) in RA, taking into account that with these new therapies a better control of inflammation is achieved. Objective The aim of the study was to evaluate the plasma concentrations of Lp(a) in Spanish RA patients on BT attending rheumatology outpatient clinics. Methods Baseline analysis of the CARdiovascular in rheuMAtology project, a 10-year prospective study, evaluating the risk of cardiovascular events in RA and other forms of inflammatory arthritis. RA patients were classified according to treatment: no biologic, anti-tumor necrosis factor, anti-interleukin-6 receptor tocilizumab (TCZ), and other biologic (rituximab or abatacept). A model of linear multivariate regression was built in which the dependent variable was Lp(a) concentration and the explanatory variable was BT. The model was adjusted for confounding factors. Results Seven hundred and seventy-five RA patients were analyzed. Plasma concentrations of total cholesterol and triglyceride were significantly higher in TCZ-treated patients. Nevertheless, no significant difference in the atherogenic index between TCZ-treated patients and patients without BT was found. After adjusting for confounding factors, patients with BT had lower concentrations of Lp(a) than those without BT; however, only TCZ-treated patients achieved statistically significant differences (?: ?0.303, 95% confidence interval: ?0.558 to ?0.047; P = .02). Conclusions RA patients treated with TCZ show lower plasma concentrations of Lp(a) compared with patients without BT. This project has been supported by an unrestricted grant from Abbvie, Spain. The design, analysis, interpretation of results, and preparation of the article have been done independently of Abbvie. Dr González-Gay's studies have been supported by grants from “Fondo de Investigaciones Sanitarias” PI06/0024, PS09/00748, and PI12/00060 and RD12/0009/0013 (RIER) from “Instituto de Salud Carlos III” (ISCIII) (Spain).

Published
2017

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