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18 results on '"Bebarova, Marketa"'

11. Aminophylline Induces Two Types of Arrhythmic Events in Human Pluripotent Stem Cell–Derived Cardiomyocytes

Author

Klimovic, Simon, primary, Scurek, Martin, additional, Pesl, Martin, additional, Beckerova, Deborah, additional, Jelinkova, Sarka, additional, Urban, Tomas, additional, Kabanov, Daniil, additional, Starek, Zdenek, additional, Bebarova, Marketa, additional, Pribyl, Jan, additional, Rotrekl, Vladimir, additional, and Brat, Kristian, additional

Published
2022
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12. Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation

Author

Bebarova, Marketa, O'Hara, Tom, Geelen, Jan L.M.C., Jongbloed, Roselie J., Timmermans, Carl, Arens, Yvonne H., Rodriguez, Luz-Maria, Rudy, Yoram, and Volders, Paul G.A.

Subjects
Genetic disorders -- Complications and side effects, Cardiac arrest -- Risk factors, Cardiac arrest -- Diagnosis, Electrocardiogram -- Usage, Electrocardiography -- Usage, Biological sciences
Abstract

Two mechanisms are generally proposed to explain right precordial ST-segment elevation in Brugada syndrome: 1) right ventricular (RV) subepicardial action potential shortening and/or loss of dome causing transmural dispersion of repolarization; and 2) RV conduction delay. Here we report novel mechanistic insights into ST-segment elevation associated with a [Na.sup.+] current ([I.sub.Na]) loss-of-function mutation from studies in a Dutch kindred with the COOH-terminal SCN5A variant p.Phe2004Leu. The proband, a man, experienced syncope at age 22 yr and had coved-type ST-segment elevations in ECG leads V1 and V2 and negative T waves in V2. Peak and persistent mutant [I.sub.Na] were significantly decreased. [I.sub.Na] closed-state inactivation was increased, slow inactivation accelerated, and recovery from inactivation delayed. Computer-simulated [I.sub.Na]-dependent excitation was decremental from endo- to epicardium at cycle length 1,000 ms, not at cycle length 300 ms. Propagation was discontinuous across the midmyocardial to epicardial transition region, exhibiting a long local delay due to phase 0 block. Beyond this region, axial excitatory current was provided by phase 2 (dome) of the M-cell action potentials and depended on L-type [Ca.sup.2+] current ('phase 2 conduction'). These results explain right precordial ST-segment elevation on the basis of RV transmural gradients of membrane potentials during early repolarization caused by discontinuous conduction. The late slow-upstroke action potentials at the subepicardium produce T-wave inversion in the computed ECG waveform, in line with the clinical ECG. arrhythmia (mechanisms); computer modeling; conduction (block); electrocardiogram; sodium channel

Published
2008

16. Contributors

Author

Albakri, Aref, AlMahameed, Soufian T., Andršová, Irena, Asirvatham, Samuel J., Avari Silva, Jennifer N., Bacharova, Ljuba, Bagliani, Giuseppe, Barakat, Rody, Barakat, Michel M., Barletta, Valentina, Barthel, Petra, Bébarová, Markéta, Beck, Hiroko, Belhassen, Bernard, Bende, Girish, Berkefeld, Anna, Birgersdotter-Green, Ulrika, Blinova, Ksenia, Blomström-Lundqvist, Carina, Bongiorni, Maria Grazia, Brand, Thomas, Bugiardini, Raffaele, Bunch, T. Jared, Castiglione, Alessandro, Cenko, Edina, Chatzidou, Sofia, Chee, Jennifer, Chelu, Mihail G., Chen, Shih Ann, Ciconte, Giuseppe, Curtis, Anne B., Curtis, Stephanie, Cygankiewicz, Iwona, Dalal, Aarti S., Day, John D., Della Tommasina, Veronica, Deshmukh, Abhishek J., Dilaveris, Polychronis, Di Summa, Roberto, Dogan, Mehmet, Dong, Jun, du Fay de Lavallaz, Jeanne, Eckhardt, Lee L., Efimova, Elena, Ernst, Sabine, Fawzy, Ameenathul M., Gaita, Fiorenzo, Garber, Libet, Garnett, Christine, Georgiopoulos, Georgios, Gillis, Anne M., Giustetto, Carla, Gonzalez Corcia, M. Cecilia, Haim, Moti, Halliday, Brian P., Hamdan, Mohamed H., Hammersley, Daniel J., Hartikainen, Juha E.K., Haugaa, Kristina H., Haukilahti, M. Anette E., Hautala, Arto J., Helánová, Kateřina, Hnatkova, Katerina, Hu, Yu-Feng, Hu, Xiao, Hurley, David, Iwai, Sei, Jacobs, Victoria, Jacobson, Jason T., James, Cynthia A., Jiang, Hongying, Jones, Camelle, Jones, Richard E., Junttila, M. Juhani, Kadish, Alan H., Karavirta, Laura, Karim, Saima, Karnad, Dilip, Karunatilleke, Anne, Kaufman, Elizabeth S., Kenttä, Tuomas V., Kezerle, Louise, Khalil, Fouad M., Klingenheben, Thomas, Kloosterman, M., Kontogiannis, Christos, Kowlgi, Gurukripa N., Kroman, Anne M., Kutyifa, Valentina, Lampert, Rachel, Laukkanen, Jari, Lee, Hyon Jae, Leinveber, Pavel, Leren, Ida S., Lima, Fabio V., Linde, Cecilia, Locati, Emanuela T., Macfarlane, Peter W., Maclachlan, Hamish, Mäkikallio, Timo H., Malik, Marek, Manfrini, Olivia, Marashly, Qussay, Margioula, Eleni, McCaffrey, James A., Mehra, Nandini S., Milman, Anat, Moharem-Elgamal, Sarah, Mujović, Nebojša, Nagarajan, Darbhamulla V., Nemec, Petr, Novotný, Tomáš, O'Neill, Louisa, Odening, Katja E., Panicker, Gopi Krishna, Pappone, Carlo, Patton, Kristen K., Pelter, Michele M., Peyracchia, Mattia, Potpara, Tratjana, Powell, Benjamin E., Preben, Bjerregaard, Sarkozy, Andrea, Schneider, Birke, Segreti, Luca, Selzman, Kimberly A., Sharma, Sanjay, Šišáková, Martina, Spears, D.A., Spera, Francesco Raffaele, Špinarová, Lenka, Stein, Phyllis K., Stergiopoulos, Kathleen, Sticherling, Christian, Stuart, Graham, Sugrue, Alan M., Svennberg, Emma, Tada, Hiroshi, Tampakis, Konstantinos, Tereshchenko, Larisa G., Terho, Henri, te Riele, Anneline S.J.M., Tikkanen, Jani T., Toman, Ondřej, Toso, Elisabetta, Tracy, Cynthia M., Trifunovic, Danijela, Turner, James M.A., Vaidya, Vaibhav R., Van Gelder, Isabelle C., Vasavan, Tharni, Verrier, Richard L., Veseli, Granit, Vicente, Jose, Williamson, Catherine, Wu, Wendy W., YH. Lip, Gregory, Younis, Arwa, Zabel, Markus, Zathar, Zafraan, Zegre-Hemsey, Jessica K., Zheng, Nan, and Zucchelli, Giulio

Published
2020
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