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Introduction: the aim of this study was to identify factors associated with genital prolapse in the gynecology and obstetrics service of Saint Joseph hospital of Kinshasa., Methods: this was a retrospective case-control study conducted from 148 medical files of patients admitted in the gynecology and obstetrics service of Saint Joseph hospital from January 1, 2008 to December 31, 2017. It was based on the non-probabilistic sampling of suitability for cases selection. The T-student test, Chi-test and logistic regression were used in statistical analyses., Results: five factors independently associated with genital prolapse were identifying: obesity with BMI≥30Kg/m 2 (OR: 3.770, 95% CI: 1.040-9.250; p=0.001), menopause (OR: 1.910, 95% CI: 1.090-10.930; p=0.001), fœtal macrosomia (OR: 4.290, 95% CI: 3.320-5.550; p=0.000), vaginal delivery (OR: 2.070, 95% CI: 1.010-5.210; p=0.006) and perineal tears (OR: 1.510, 95% CI: 1.250-1.910; p=0.000)., Conclusion: these factors independently associated with genital prolapse can be used for screening of high-risk women in gynecological and obstetrical consultations in order to improve the treatment of genital prolapse in our milieu., (Copyright: Antoine Tshimbundu Kayembe et al.)