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187 results on '"Bechard, Lori J."'

6. Changes in global nutrition practices in critically ill children and the impact of emerging evidence: a secondary analysis of the Pediatric International Nutrition Studies (PINS), 2009-2018

Author

Akhondi-Asl, Alireza, primary, Ariagno, Katelyn, additional, Fluckiger, Larissa, additional, Jotterand Chaparro, Corinne, additional, Martinez, Enid E., additional, Moreno, Yara M.F., additional, Ong, Chengsi, additional, Skillman, Heather E., additional, Tume, Lyvonne, additional, Mehta, Nilesh M., additional, and Bechard, Lori J., additional

Published
2024
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7. Stress Ulcer Prophylaxis Versus Placebo—A Blinded Pilot Randomized Controlled Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease

Author

Mills, Kimberly I., primary, Albert, Ben D., additional, Bechard, Lori J., additional, Chu, Stephen, additional, Duggan, Christopher P., additional, Kaza, Aditya, additional, Rakoff-Nahoum, Seth, additional, Sleeper, Lynn A., additional, Newburger, Jane W., additional, Priebe, Gregory P., additional, and Mehta, Nilesh M., additional

Published
2024
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24. Stress Ulcer Prophylaxis versus Placebo - a Blinded Randomized Control Trial toEvaluate the Safety of Two Strategies in Critically Ill Infants with Congenital Heart Disease (SUPPRESS-CHD)

Author

Mills, Kimberly I., primary, Albert, Ben D., additional, Bechard, Lori J., additional, Duggan, Christopher P., additional, Kaza, Aditya, additional, Rakoff-Nahoum, Seth, additional, Vlamakis, Hera, additional, Sleeper, Lynn A., additional, Newburger, Jane W., additional, Priebe, Gregory P., additional, and Mehta, Nilesh, additional

Published
2020
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26. Additional file 1 of Stress ulcer prophylaxis versus placebo—a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD)

Author

Mills, Kimberly I., Albert, Ben D., Bechard, Lori J., Duggan, Christopher P., Kaza, Aditya, Rakoff-Nahoum, Seth, Vlamakis, Hera, Sleeper, Lynn A., Newburger, Jane W., Priebe, Gregory P., and Mehta, Nilesh M.

Abstract

Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents.

Published
2020
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32. Stress Ulcer Prophylaxis versus Placebo - a Blinded Randomized Control Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants with Congenital Heart Disease (SUPPRESS-CHD)

Author

Mills, Kimberly I., primary, Albert, Ben D., additional, Bechard, Lori J., additional, Duggan, Christopher P., additional, Kaza, Aditya, additional, Rakoff-Nahoum, Seth, additional, Vlamakis, Hera, additional, Sleeper, Lynn A., additional, Newburger, Jane W., additional, Priebe, Gregory P., additional, and Mehta, Nilesh, additional

Published
2020
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34. Attenuation of resting energy expenditure following hematopoietic stem cell transplantation in children

Author

Bechard, Lori J., Feldman, Henry A., Venick, Robert, Gura, Kathleen, Gordon, Catherine, Sonis, Andrew, Mehta, Nilesh, Guinan, Eva C., and Duggan, Christopher

Subjects
indirect calorimetry, Adult, Male, Parenteral Nutrition, Time Factors, Adolescent, Rest, Siblings, Hematopoietic Stem Cell Transplantation, energy balance, Article, Body Mass Index, Double-Blind Method, Hematologic Neoplasms, energy expenditure, Humans, Transplantation, Homologous, Female, Prospective Studies, Child, Energy Intake, Energy Metabolism, Unrelated Donors
Abstract

Background Children undergoing hematopoietic stem cell transplantation (HSCT) typically receive parenteral nutrition (PN) due to gastrointestinal toxicities. Accurate determination of resting energy expenditure (REE) may facilitate optimal energy provision and help avoid unintended overfeeding or underfeeding. Methods In a multicenter, prospective cohort study of children undergoing allogeneic HSCT, REE was measured by indirect calorimetry at baseline and twice weekly until 30 days after transplantation. Change in percent predicted REE over time from admission was analyzed using repeated measures regression analysis. Results Twenty-six children (14 females) with a mean (SD) age of 14.9 (4.2) years who underwent an HLA-matched sibling or unrelated donor transplantation were enrolled. Mean (SD) percent predicted REE at baseline was 92.4 (15.2). Baseline REE was highly correlated with lean body mass measured by DXA (r=0.78, p

Published
2012

40. Influence of Obesity on Clinical Outcomes in Hospitalized Children

Author

Bechard, Lori J., Rothpletz-Puglia, Pamela, Touger-Decker, Riva, Duggan, Christopher, and Mehta, Nilesh M.

Subjects
Hospitalization, Cross Infection, Treatment Outcome, Adolescent, Child, Preschool, Humans, Hospital Mortality, Obesity, Length of Stay, Child, Pediatrics, Article
Abstract

Obesity is prevalent among hospitalized children. Knowledge of the relationship between obesity and outcomes in hospitalized children will enhance nutrition assessment and provide opportunities for interventions.To systematically review the existing literature concerning the impact of obesity on clinical outcomes in hospitalized children.PubMed, Web of Science, and EMBASE databases were searched for studies of hospitalized children aged 2 to 18 years with identified obesity and at least 1 of the following clinical outcomes: all-cause mortality, incidence of infections, and length of hospital stay. Cohort and case-control studies were included. Cross-sectional studies, studies of healthy children, and those without defined criteria for classifying weight status were excluded. The Newcastle-Ottawa Scale was used to assess study quality.Twenty-eight studies (26 retrospective; 24 cohort and 4 case-control) were included. Of the 21 studies that included mortality as an outcome, 10 reported a significant positive relationship between obesity and mortality. The incidence of infections was assessed in 8 of the 28 studies; 2 reported significantly more infections in obese compared with nonobese patients. Of the 11 studies that examined length of stay, 5 reported significantly longer lengths of hospital stay for obese children. Fifteen studies (53%) had a high quality score. Larger studies observed significant relationships between obesity and outcomes. Studies of critically ill, oncologic or stem cell transplant, and solid organ transplant patients showed a relationship between obesity and mortality.The available literature on the relationship between obesity and clinical outcomes is limited by subject heterogeneity, variations in criteria for defining obesity, and outcomes examined. Childhood obesity may be a risk factor for higher mortality in hospitalized children with critical illness, oncologic diagnoses, or transplants. Further examination of the relationship between obesity and clinical outcomes in this subgroup of hospitalized children is needed.

Published
2013

42. Feasibility of Enteral Protein Supplementation in Critically Ill Children.

Author

Moreno, Yara M. F., Hauschild, Daniela B., Martins, Mayara D., Bechard, Lori J., and Mehta, Nilesh M.

Subjects
CRITICALLY ill, ENTERAL feeding, INFANT formulas, INGESTION, INTENSIVE care units, LONGITUDINAL method, MEDICAL cooperation, PATIENTS, PEDIATRICS, DIETARY proteins, RESEARCH, OSMOLAR concentration, DESCRIPTIVE statistics, CHILDREN
Abstract

Background: We describe the protein type and concentration in standard enteral nutrition (EN) formulas and the effect of protein supplementation on the osmolality of standard formulas. We also aimed to examine factors associated with optimal protein delivery in critically ill children.Methods: Protein content and other characteristics of pediatric EN formulas used worldwide were recorded. Factors associated with achievement of recommended protein delivery and tolerance of protein-supplemented formulas were recorded prospectively in a cohort of critically ill children. A range of protein supplement doses was added to 2 standard formulas and water, and the osmolality was recorded by cryoscopy in a bench experiment.Results: We reviewed 125 formulas used in a multicenter study including sites from >13 countries. A majority of the EN formulas (73.6%) were polymeric, with a nonprotein calorie/nitrogen ratio of 182 ± 66 and protein content of 3.53 ± 2.00 g/100 mL. In the cohort of critically ill children, 28.5% achieved protein intake goal within 4 days, with no intolerance. In addition to optimal protein prescription (P < 0.001), protein supplementation (P = 0.018) and early EN initiation (P = 0.006) were associated with significantly higher odds of achieving goal protein intake. Formulas supplemented with up to 8 g/100 mL polymeric protein had osmolality <450 mOsm/kg.Conclusions: The protein content of current pediatric formulas may be inadequate to meet the needs of critically ill children. Protein supplementation of formulas allows early achievement of goal and is likely to be safe.). [ABSTRACT FROM AUTHOR]

Published
2018
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43. Importance of Dietary Sources of Iron in Infants and Toddlers: Lessons from the FITS Study.

Author

Finn, Kristen, Callen, Cheryl, Bhatia, Jatinder, Reidy, Kathleen, Bechard, Lori J., and Carvalho, Ryan

Abstract

Iron deficiency (ID) affects 13.5% of 1-2 years old children in the US and may have a negative impact on neurodevelopment and behavior. Iron-fortified infant cereal is the primary non-heme iron source among infants aged 6-11.9 months. The objective of this study was to compare iron intakes of infant cereal users with non-users. Data from the Feeding Infants and Toddlers Study 2008 were used for this analysis. Based on a 24-h recall, children between the ages of 4-17.9 months were classified as 'cereal users' if they consumed any amount or type of infant cereal and 'non-users' if they did not. Infant cereal was the top source of dietary iron among infants aged 6-11.9 months. The majority of infants (74.6%) aged 6-8.9 months consumed infant cereal, but this declined to 51.5% between 9-11.9 months and 14.8% among 12-17.9 months old toddlers. Infant cereal users consumed significantly more iron than non-users across all age groups. Infants and toddlers who consume infant cereal have higher iron intakes compared to non-users. Given the high prevalence of ID, the appropriate use of infant cereals in a balanced diet should be encouraged to reduce the incidence of ID and ID anemia. [ABSTRACT FROM AUTHOR]

Published
2017
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