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357 results on '"Becher, Oren J."'

2. BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma

Author

Watanabe, Jun, Clutter, Matthew R., Gullette, Michael J., Sasaki, Takahiro, Uchida, Eita, Kaur, Savneet, Mo, Yan, Abe, Kouki, Ishi, Yukitomo, Takata, Nozomu, Natsumeda, Manabu, Gadd, Samantha, Zhang, Zhiguo, Becher, Oren J., and Hashizume, Rintaro

Subjects
Gene expression -- Analysis, Methylation -- Health aspects, Gliomas -- Diagnosis -- Care and treatment -- Genetic aspects, Radiotherapy -- Patient outcomes, Health care industry, Diagnosis, Care and treatment, Analysis, Genetic aspects, Patient outcomes, Health aspects
Abstract

Diffuse midline glioma (DMG) H3K27-altered is one of the most malignant childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only 1%. Several clinical trials have attempted to enhance radiation antitumor activity using radiosensitizing agents, although none have been successful. Given this, there is a critical need for identifying effective therapeutics to enhance radiation sensitivity for the treatment of DMG. Using high-throughput radiosensitivity screening, we identified bromo- and extraterminal domain (BET) protein inhibitors as potent radiosensitizers in DMG cells. Genetic and pharmacologic inhibition of BET bromodomain activity reduced DMG cell proliferation and enhanced radiation-induced DNA damage by inhibiting DNA repair pathways. RNA-Seq and the CUT&RUN (cleavage under targets and release using nuclease) analysis showed that BET bromodomain inhibitors regulated the expression of DNA repair genes mediated by H3K27 acetylation at enhancers. BET bromodomain inhibitors enhanced DMG radiation response in patient-derived xenografts as well as genetically engineered mouse models. Together, our results highlight BET bromodomain inhibitors as potential radiosensitizer and provide a rationale for developing combination therapy with radiation for the treatment of DMG., Introduction Diffuse midline gliomas (DMGs) with H3K27M mutation (histone H3 lysine 27 replaced with methionine) are diffusely infiltrating glial neoplasms affecting midline structures of the CNS (1). DMG is one [...]

Published
2024
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3. TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

Author

Ausejo-Mauleon, Iker, Labiano, Sara, de la Nava, Daniel, Laspidea, Virginia, Zalacain, Marta, Marrodán, Lucía, García-Moure, Marc, González-Huarriz, Marisol, Hervás-Corpión, Irati, Dhandapani, Laasya, Vicent, Silvestre, Collantes, Maria, Peñuelas, Iván, Becher, Oren J., Filbin, Mariella G., Jiang, Li, Labelle, Jenna, de Biagi-Junior, Carlos A.O., Nazarian, Javad, Laternser, Sandra, Phoenix, Timothy N., van der Lugt, Jasper, Kranendonk, Mariette, Hoogendijk, Raoull, Mueller, Sabine, De Andrea, Carlos, Anderson, Ana C., Guruceaga, Elizabeth, Koschmann, Carl, Yadav, Viveka Nand, Gállego Pérez-Larraya, Jaime, Patiño-García, Ana, Pastor, Fernando, and Alonso, Marta M.

Published
2023
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4. Recombinant polio–rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial

Author

Thompson, Eric M, Landi, Daniel, Brown, Michael C, Friedman, Henry S, McLendon, Roger, Herndon, James E, II, Buckley, Evan, Bolognesi, Dani P, Lipp, Eric, Schroeder, Kristin, Becher, Oren J, Friedman, Allan H, McKay, Zachary, Walter, Ashley, Threatt, Stevie, Jaggers, Denise, Desjardins, Annick, Gromeier, Matthias, Bigner, Darell D, and Ashley, David M

Published
2023
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7. The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models

Author

de la Nava, Daniel, primary, Ausejo-Mauleon, Iker, additional, Laspidea, Virginia, additional, Gonzalez-Huarriz, Marisol, additional, Lacalle, Andrea, additional, Casares, Noelia, additional, Zalacain, Marta, additional, Marrodan, Lucía, additional, García-Moure, Marc, additional, Ochoa, Maria C, additional, Tallon-Cobos, Antonio Carlos, additional, Hernandez-Osuna, Reyes, additional, Marco-Sanz, Javier, additional, Dhandapani, Laasya, additional, Hervás-Corpión, Irati, additional, Becher, Oren J, additional, Nazarian, Javad, additional, Mueller, Sabine, additional, Phoenix, Timothy N, additional, van der Lugt, Jasper, additional, Hernaez, Mikel, additional, Guruceaga, Elizabeth, additional, Koschmann, Carl, additional, Venneti, Sriram, additional, Allen, Joshua E, additional, Dun, Matthew D, additional, Fueyo, Juan, additional, Gomez-Manzano, Candelaria, additional, Perez-Larraya, Jaime Gallego, additional, Patiño-García, Ana, additional, Labiano, Sara, additional, and Alonso, Marta M, additional

Published
2024
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8. Pediatric high-grade glioma: biologically and clinically in need of new thinking.

Author

Jones, Chris, Karajannis, Matthias A, Jones, David TW, Kieran, Mark W, Monje, Michelle, Baker, Suzanne J, Becher, Oren J, Cho, Yoon-Jae, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A, Jabado, Nada, Li, Xiao-Nan, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J, Persson, Anders I, Phillips, Joanna J, Simonds, Erin F, Stafford, James M, Tang, Yujie, Pfister, Stefan M, and Weiss, William A

Subjects
Humans, Glioma, Brain Neoplasms, Cell Transformation, Neoplastic, Prognosis, Child, Neoplasm Grading, DIPG, clinical trials, genomics, glioma, pediatric, Clinical Trials and Supportive Activities, Rare Diseases, Brain Cancer, Neurosciences, Brain Disorders, Pediatric, Cancer, Clinical Research, Orphan Drug, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed previously unappreciated connections among chromatin regulation, developmental signaling, and tumorigenesis. As we begin to unravel the unique developmental origins and distinct biological drivers of this heterogeneous group of tumors, clinical trials need to keep pace. It is important to avoid therapeutic strategies developed purely using data obtained from studies on adult glioblastoma. This approach has resulted in repetitive trials and ineffective treatments being applied to these children, with limited improvement in clinical outcome. The authors of this perspective, comprising biology and clinical expertise in the disease, recently convened to discuss the most effective ways to translate the emerging molecular insights into patient benefit. This article reviews our current understanding of pediatric high-grade glioma and suggests approaches for innovative clinical management.

Published
2017

9. RETRACTED ARTICLE: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

Author

Garancher, Alexandra, Suzuki, Hiromichi, Haricharan, Svasti, Chau, Lianne Q., Masihi, Meher Beigi, Rusert, Jessica M., Norris, Paula S., Carrette, Florent, Romero, Megan M., Morrissy, Sorana A., Skowron, Patryk, Cavalli, Florence M. G., Farooq, Hamza, Ramaswamy, Vijay, Jones, Steven J. M., Moore, Richard A., Mungall, Andrew J., Ma, Yussanne, Thiessen, Nina, Li, Yisu, Morcavallo, Alaide, Qi, Lin, Kogiso, Mari, Du, Yuchen, Baxter, Patricia, Henderson, Jacob J., Crawford, John R., Levy, Michael L., Olson, James M., Cho, Yoon-Jae, Deshpande, Aniruddha J., Li, Xiao-Nan, Chesler, Louis, Marra, Marco A., Wajant, Harald, Becher, Oren J., Bradley, Linda M., Ware, Carl F., Taylor, Michael D., and Wechsler-Reya, Robert J.

Published
2020
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10. Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

Author

Shen, Ying, Li, Jie, Nitta, Masayuki, Futalan, Diahnn, Steed, Tyler, Treiber, Jeffrey M, Taich, Zack, Stevens, Deanna, Wykosky, Jill, Chen, Hong-Zhuan, Carter, Bob S, Becher, Oren J, Kennedy, Richard, Esashi, Fumiko, Sarkaria, Jann N, Furnari, Frank B, Cavenee, Webster K, Desai, Arshad, and Chen, Clark C

Subjects
Brain Disorders, Cancer, Brain Cancer, Rare Diseases, Genetics, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Antineoplastic Agents, Alkylating, Blotting, Western, Brain Neoplasms, Cell Cycle Proteins, Cell Line, Tumor, Comet Assay, DNA Damage, Dacarbazine, ErbB Receptors, Flow Cytometry, Fluorescent Antibody Technique, Gene Knockout Techniques, Glioblastoma, Heterografts, Humans, Mice, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins, RNA, Small Interfering, Temozolomide, EGFR, EGFRvIII, glioblastoma, synthetic lethality, Oncology and Carcinogenesis
Abstract

We identified a synthetic lethality between PLK1 silencing and the expression of an oncogenic Epidermal Growth Factor Receptor, EGFRvIII. PLK1 promoted homologous recombination (HR), mitigating EGFRvIII induced oncogenic stress resulting from DNA damage accumulation. Accordingly, PLK1 inhibition enhanced the cytotoxic effects of the DNA damaging agent, temozolomide (TMZ). This effect was significantly more pronounced in an Ink4a/Arf(-/-) EGFRvIII glioblastoma model relative to an Ink4a/Arf(-/-) PDGF-β model. The tumoricidal and TMZ-sensitizing effects of BI2536 were uniformly observed across Ink4a/Arf(-/-) EGFRvIII glioblastoma clones that acquired independent resistance mechanisms to EGFR inhibitors, suggesting these resistant clones retain oncogenic stress that required PLK1 compensation. Although BI2536 significantly augmented the anti-neoplastic effect of EGFR inhibitors in the Ink4a/Arf(-/-) EGFRvIII model, durable response was not achieved until TMZ was added. Our results suggest that optimal therapeutic effect against glioblastomas requires a "multi-orthogonal" combination tailored to the molecular physiology associated with the target cancer genome.

Published
2015

11. Ataxia-telangiectasia mutated(Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

Author

Mangoli, Avani, primary, Wu, Sophie, additional, Liu, Harrison Q., additional, Aksu, Michael, additional, Jain, Vaibhav, additional, Foreman, Bronwen E., additional, Regal, Joshua A., additional, Weidenhammer, Loren B., additional, Stewart, Connor E., additional, Guerra Garcia, Maria E., additional, Hocke, Emily, additional, Abramson, Karen, additional, Williams, Nerissa T., additional, Luo, Lixia, additional, Deland, Katherine, additional, Attardi, Laura, additional, Abe, Kouki, additional, Hashizume, Rintaro, additional, Ashley, David M., additional, Becher, Oren J., additional, Kirsch, David G., additional, Gregory, Simon G., additional, and Reitman, Zachary J., additional

Published
2023
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12. Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

Author

Garancher, Alexandra, Suzuki, Hiromichi, Haricharan, Svasti, Chau, Lianne Q., Masihi, Meher Beigi, Rusert, Jessica M., Norris, Paula S., Carrette, Florent, Romero, Megan M., Morrissy, Sorana A., Skowron, Patryk, Cavalli, Florence M. G., Farooq, Hamza, Ramaswamy, Vijay, Jones, Steven J. M., Moore, Richard A., Mungall, Andrew J., Ma, Yussanne, Thiessen, Nina, Li, Yisu, Morcavallo, Alaide, Qi, Lin, Kogiso, Mari, Du, Yuchen, Baxter, Patricia, Henderson, Jacob J., Crawford, John R., Levy, Michael L., Olson, James M., Cho, Yoon-Jae, Deshpande, Aniruddha J., Li, Xiao-Nan, Chesler, Louis, Marra, Marco A., Wajant, Harald, Becher, Oren J., Bradley, Linda M., Ware, Carl F., Taylor, Michael D., and Wechsler-Reya, Robert J.

Published
2022
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32. Table S2 from Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma

Author

Katagi, Hiroaki, primary, Louis, Nundia, primary, Unruh, Dusten, primary, Sasaki, Takahiro, primary, He, Xingyao, primary, Zhang, Ali, primary, Ma, Quanhong, primary, Piunti, Andrea, primary, Shimazu, Yosuke, primary, Lamano, Jonathan B., primary, Carcaboso, Angel M., primary, Tian, Xiao, primary, Seluanov, Andrei, primary, Gorbunova, Vera, primary, Laurie, Kathryn L., primary, Kondo, Akihide, primary, Wadhwani, Nitin R., primary, Lulla, Rishi, primary, Goldman, Stewart, primary, Venneti, Sriram, primary, Becher, Oren J., primary, Zou, Lihua, primary, Shilatifard, Ali, primary, and Hashizume, Rintaro, primary

Published
2023
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33. Data from Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma

Author

Katagi, Hiroaki, primary, Louis, Nundia, primary, Unruh, Dusten, primary, Sasaki, Takahiro, primary, He, Xingyao, primary, Zhang, Ali, primary, Ma, Quanhong, primary, Piunti, Andrea, primary, Shimazu, Yosuke, primary, Lamano, Jonathan B., primary, Carcaboso, Angel M., primary, Tian, Xiao, primary, Seluanov, Andrei, primary, Gorbunova, Vera, primary, Laurie, Kathryn L., primary, Kondo, Akihide, primary, Wadhwani, Nitin R., primary, Lulla, Rishi, primary, Goldman, Stewart, primary, Venneti, Sriram, primary, Becher, Oren J., primary, Zou, Lihua, primary, Shilatifard, Ali, primary, and Hashizume, Rintaro, primary

Published
2023
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34. Figure S1 from Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma

Author

Katagi, Hiroaki, primary, Louis, Nundia, primary, Unruh, Dusten, primary, Sasaki, Takahiro, primary, He, Xingyao, primary, Zhang, Ali, primary, Ma, Quanhong, primary, Piunti, Andrea, primary, Shimazu, Yosuke, primary, Lamano, Jonathan B., primary, Carcaboso, Angel M., primary, Tian, Xiao, primary, Seluanov, Andrei, primary, Gorbunova, Vera, primary, Laurie, Kathryn L., primary, Kondo, Akihide, primary, Wadhwani, Nitin R., primary, Lulla, Rishi, primary, Goldman, Stewart, primary, Venneti, Sriram, primary, Becher, Oren J., primary, Zou, Lihua, primary, Shilatifard, Ali, primary, and Hashizume, Rintaro, primary

Published
2023
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35. Supplementary Figure 3 from Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Walker, Talia R., primary, Helmy, Karim, primary, Nazarian, Javad, primary, Albrecht, Steffen, primary, Hiner, Rebecca L., primary, Gall, Sarah, primary, Huse, Jason T., primary, Jabado, Nada, primary, MacDonald, Tobey J., primary, and Holland, Eric C., primary

Published
2023
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36. Supplementary Figure 2 from Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Walker, Talia R., primary, Helmy, Karim, primary, Nazarian, Javad, primary, Albrecht, Steffen, primary, Hiner, Rebecca L., primary, Gall, Sarah, primary, Huse, Jason T., primary, Jabado, Nada, primary, MacDonald, Tobey J., primary, and Holland, Eric C., primary

Published
2023
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38. Supplementary Figure 8 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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39. Supplementary Methods and Materials from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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41. Supplementary Figure 7 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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42. Supplementary Figure 10 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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43. Supplementary Figure 2 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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44. Supplementary Figure 3 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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45. Supplementary Figure 9 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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46. Supplementary Figure 5 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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47. Supplementary Figure 6 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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48. Supplementary Figure 1 from Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Walker, Talia R., primary, Helmy, Karim, primary, Nazarian, Javad, primary, Albrecht, Steffen, primary, Hiner, Rebecca L., primary, Gall, Sarah, primary, Huse, Jason T., primary, Jabado, Nada, primary, MacDonald, Tobey J., primary, and Holland, Eric C., primary

Published
2023
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49. Supplementary Figure 4 from Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor–Induced Gliomas

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Fomchenko, Elena I., primary, Momota, Hiroyuki, primary, Mainwaring, Lori, primary, Bleau, Anne-Marie, primary, Katz, Amanda M., primary, Edgar, Mark, primary, Kenney, Anna M., primary, Cordon-Cardo, Carlos, primary, Blasberg, Ron G., primary, and Holland, Eric C., primary

Published
2023
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50. Supplementary Figure 4 from Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma

Author

Becher, Oren J., primary, Hambardzumyan, Dolores, primary, Walker, Talia R., primary, Helmy, Karim, primary, Nazarian, Javad, primary, Albrecht, Steffen, primary, Hiner, Rebecca L., primary, Gall, Sarah, primary, Huse, Jason T., primary, Jabado, Nada, primary, MacDonald, Tobey J., primary, and Holland, Eric C., primary

Published
2023
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