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1. Smallest Clinically Meaningful Improvement in Amputation-Related Pain and Brief Pain Inventory Scores as Defined by Patient Reports of Global Improvement After Cryoneurolysis: a Retrospective Analysis of a Randomized, Controlled Clinical Trial

Author

Ilfeld, Brian M., Smith, Cameron R., Turan, Alparslan, Mariano, Edward R., Miller, Matthew E., Fisher, Rick L., Trescot, Andrea M., Cohen, Steven P., Eisenach, James C., Sessler, Daniel I., Prologo, J. David, Mascha, Edward J., Liu, Liu, Gabriel, Rodney A., Hayek, Salim M., Wadhwa, Anupama N., Beck, Gerald J., Abdullah, Baharin, Ali Sakr Esa, Wael, Altinpulluk, Ece Yamak, Bakal, Omer, Bravo, Mauro, Jiang, Qiliang, Khan, Zafeer, Maheshwari, Kamal, Mounir-Soliman, Loran, Salih, Ahmed, Hackworth, Robert J., Sigmon, Carter, Padwal, Jennifer, Gunnett, Amy M., Thaper, Akshay, and Hunt, Morgan

Published
2024
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3. A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

Author

Inker, Lesley A, Couture, Sara J, Tighiouart, Hocine, Abraham, Alison G, Beck, Gerald J, Feldman, Harold I, Greene, Tom, Gudnason, Vilmundur, Karger, Amy B, Eckfeldt, John H, Kasiske, Bertram L, Mauer, Michael, Navis, Gerjan, Poggio, Emilio D, Rossing, Peter, Shlipak, Michael G, Levey, Andrew S, Collaborators, CKD-EPI GFR, Andresdottir, Margret B, Gudmundsdottir, Hrefna, Indridason, Olafur S, Palsson, Runolfur, Kimmel, Paul, Weir, Matt, Kalil, Roberto, Pesavento, Todd, Porter, Anna, Taliercio, Jonathan, Hsu, Chi-yuan, Chen, Jing, Sinkeler, Steef, Wyatt, Christina, Krishnasami, Zipporah, Hellinger, James, Margolick, Joseph, Kingsley, Lawrence, Witt, Mallory, Wolinsky, Steven, Shafi, Tariq, Post, Wendy, Doria, Alessandro, and Parving, Hans-Henrik

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Disparities, Clinical Research, Kidney Disease, Minority Health, 4.2 Evaluation of markers and technologies, Renal and urogenital, Adolescent, Adult, Black or African American, Aged, Aged, 80 and over, Black People, Case-Control Studies, Chromium Radioisotopes, Creatinine, Cystatin C, Edetic Acid, Female, Glomerular Filtration Rate, Humans, Intramolecular Oxidoreductases, Iohexol, Iothalamic Acid, Lipocalins, Male, Middle Aged, Renal Insufficiency, Chronic, Reproducibility of Results, Severity of Illness Index, White People, Young Adult, beta 2-Microglobulin, CKD-EPI GFR Collaborators, African American, Black race, GFR estimation, Glomerular filtration rate, bias, creatinine, cystatin C, estimating equations, filtration marker, kidney disease diagnosis, laboratory testing, race, race-based medicine, renal function, β(2)-microglobulin, β-trace protein, Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Rationale and objectiveGlomerular filtration rate (GFR) estimation based on creatinine and cystatin C (eGFRcr-cys) is more accurate than estimated GFR (eGFR) based on creatinine or cystatin C alone (eGFRcr or eGFRcys, respectively), but the inclusion of creatinine in eGFRcr-cys requires specification of a person's race. β2-Microglobulin (B2M) and β-trace protein (BTP) are alternative filtration markers that appear to be less influenced by race than creatinine is.Study designStudy of diagnostic test accuracy.Setting and participantsDevelopment in a pooled population of 7 studies with 5,017 participants with and without chronic kidney disease. External validation in a pooled population of 7 other studies with 2,245 participants.Tests comparedPanel eGFR using B2M and BTP in addition to cystatin C (3-marker panel) or creatinine and cystatin C (4-marker panel) with and without age and sex or race.OutcomesGFR measured as the urinary clearance of iothalamate, plasma clearance of iohexol, or plasma clearance of [51Cr]EDTA.ResultsMean measured GFRs were 58.1 and 83.2 mL/min/1.73 m2, and the proportions of Black participants were 38.6% and 24.0%, in the development and validation populations, respectively. In development, addition of age and sex improved the performance of all equations compared with equations without age and sex, but addition of race did not further improve the performance. In validation, the 4-marker panels were more accurate than the 3-marker panels (P < 0.001). The 3-marker panel without race was more accurate than eGFRcys (percentage of estimates greater than 30% different from measured GFR [1 - P30] of 15.6% vs 17.4%; P = 0.01), and the 4-marker panel without race was as accurate as eGFRcr-cys (1 - P30 of 8.6% vs 9.4%; P = 0.2). Results were generally consistent across subgroups.LimitationsNo representation of participants with severe comorbid illness and from geographic areas outside of North America and Europe.ConclusionsThe 4-marker panel eGFR is as accurate as eGFRcr-cys without requiring specification of race. A more accurate race-free eGFR could be an important advance.

Published
2021

4. Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension

Author

Rischard, Franz P., Bernardo, Roberto J., Vanderpool, Rebecca R., Kwon, Deborah H., Acharya, Tushar, Park, Margaret M., Katrynuik, Austin, Insel, Michael, Kubba, Saad, Badagliacca, Roberto, Larive, A. Brett, Naeije, Robert, Garcia, Joe G.N., Beck, Gerald J., Erzurum, Serpil C., Frantz, Robert P., Hassoun, Paul M., Hemnes, Anna R., Hill, Nicholas S., Horn, Evelyn M., Leopold, Jane A., Rosenzweig, Erika B., Tang, W.H. Wilson, and Wilcox, Jennifer D.

Published
2023
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5. Non‐invasive prediction of pulmonary vascular disease‐related exercise intolerance and survival in non‐group 1 pulmonary hypertension.

Author

Reddy, Yogesh N.V., Dubrock, Hilary, Hassoun, Paul M., Hemnes, Anna, Horn, Evelyn, Leopold, Jane A., Rischard, Franz, Rosenzweig, Erika B., Hill, Nicholas S., Erzurum, Serpil C., Beck, Gerald J., Mathai, Stephen C., Mukherjee, Monica, Tang, W.H. Wilson, Borlaug, Barry A., and Frantz, Robert P.

Subjects
DISEASE risk factors, PULMONARY artery diseases, PULMONARY hypertension, AEROBIC capacity, CARDIAC output
Abstract

Aims: The clinical utility of pulmonary hypertension (PH) risk scores in non‐group 1 PH with pulmonary vascular disease (PVD) remains unresolved. Methods and results: We utilized the prospective multicenter PVDOMICS cohort with group 2, 3, 4 or 5 PH‐related PVD and calculated group 1 PH risk scores (REVEAL 2.0, REVEAL Lite 2, French registry score and COMPERA 2). The c‐statistic to predict death was compared separately in (i) pre‐capillary PH groups 3/4/5, and (ii) combined post‐ and pre‐capillary PH group 2. Exercise right heart catheterization reserve, ventricular interdependence and right ventricular–pulmonary artery (RV‐PA) coupling were compared across risk categories. Among 449 individuals with group 3/4/5 PH, the REVEAL 2.0 risk score had the highest c‐statistic for predicting death (0.699, 95% confidence interval [CI] 0.660–0.737, p < 0.0001) with comparable performance using the simpler REVEAL Lite 2 score (0.695, 95% CI 0.656–0.734, p < 0.0001). The French and COMPERA 2 risk scores were also predictive of mortality, but performance of both was statistically inferior to REVEAL 2.0 (c‐statistic difference −0.072, 95% CI −0.123 to −0.020, p = 0.006, and −0.043, 95% CI −0.067 to −0.018, p = 0.0007, respectively). RV function and RV‐PA coupling measures were prognostic in isolation, but did not add incremental value to REVEAL (p > 0.50 for all). Findings were similar in patients with group 2 PH (n = 239). Stratification by the REVEAL Lite 2 score non‐invasively identified non‐group 1 PH with more advanced PVD with worse exercise capacity, RV‐PA uncoupling, ventricular interdependence and impaired cardiac output reserve (p < 0.05 for all). Conclusions: Non‐invasive REVEAL risk predicts mortality in non‐group 1 PH without incremental prognostic value from detailed RV function or RV‐PA coupling assessment. Baseline REVEAL Lite 2 risk stratification non‐invasively identifies greater pulmonary vascular dysfunction and right heart‐related exercise limitation, which may help guide patient selection for targeted pulmonary vascular therapies in non‐group 1 PH. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Changes in Biomarker Profile and Left Ventricular Hypertrophy Regression: Results from the Frequent Hemodialysis Network Trials

Author

Chan, Christopher T, Kaysen, George A, Beck, Gerald J, Li, Minwei, Lo, Joan, Rocco, Michael V, and Kliger, Alan S

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Prevention, Clinical Research, Kidney Disease, Clinical Trials and Supportive Activities, Adult, Biomarkers, Cohort Studies, Female, Humans, Hypertrophy, Left Ventricular, Kidney Failure, Chronic, Male, Middle Aged, Randomized Controlled Trials as Topic, Remission Induction, Renal Dialysis, Frequent hemodialysis, Cardiac biomarkers, Klotho, Markers of collagen turnover, Left ventricular hypertrophy, Copeptin, Brain natriuretic peptide, FHN Trials, Copeptin, Left ventricular hypertrophy , Clinical Sciences, Urology & Nephrology, Clinical sciences
Abstract

BackgroundRegression of left ventricular hypertrophy (LVH) is feasible with more frequent hemodialysis (HD). We aimed to ascertain pathways associated with regression of left ventricular mass (LVM) in patients enrolled in the Frequent HD Network (FHN) trials.MethodsThis was a post hoc observational cohort study. We hypothesized LVH regression with frequent HD was associated with a different cardiovascular biomarker profile. Regressors were defined as patients who achieved a reduction of more than 10% in LVM at 12 months. Progressors were defined as patients who had a minimum of 10% increase in LVM at 12 months.ResultsAmong 332 randomized patients, 243 had biomarker data available. Of these, 121 patients did not progress or regress, 77 were regressors, and 45 were progressors. Mean LVM change differed between regressors and progressors by -65.6 (-74.0 to -57.2) g, p < 0.001. Regressors had a median (interquartile range) increase in dialysis frequency (from 3.0 [3.0-3.0] to 4.9 [3-5.7] per week, p = 0.001) and reductions in pre-dialysis systolic (from 149.0 [136.0-162.0] to 136.0 [123.0-152.0] mm Hg, p < 0.001) and diastolic (from 83.0 [71.0-91.0] to 76.0 [68.0-84.0] mm Hg, p < 0.001) blood pressures. Klotho levels increased in regressors versus progressors (76.9 [10.5-143.3] pg/mL, p = 0.024). Tissue inhibitors of metalloproteinase (TIMP)-2 levels fell in regressors compared to progressors (-7,853 [-14,653 to -1,052] pg/mL, p = 0.024). TIMP-1 and log (brain natriuretic -peptide [BNP]) levels also tended to fall in regressors. Changes in LVM correlated inversely with changes in klotho (r = -0.24, p = 0.014). -Conclusions: Markers of collagen turnover and changes in klotho levels are potential novel pathways associated with regression of LVH in the dialysis population, which will require further prospective validation.

Published
2018

7. A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

Author

Andresdottir, Margret B., Gudmundsdottir, Hrefna, Indridason, Olafur S., Palsson, Runolfur, Kimmel, Paul, Weir, Matt, Kalil, Roberto, Pesavento, Todd, Porter, Anna, Taliercio, Jonathan, Hsu, Chi-yuan, Chen, Jing, Sinkeler, Steef, Wyatt, Christina, Krishnasami, Zipporah, Hellinger, James, Margolick, Joseph, Kingsley, Lawrence, Witt, Mallory, Wolinsky, Steven, Shafi, Tariq, Post, Wendy, Doria, Alessandro, Parving, Hans-Henrik, Inker, Lesley A., Couture, Sara J., Tighiouart, Hocine, Abraham, Alison G., Beck, Gerald J., Feldman, Harold I., Greene, Tom, Gudnason, Vilmundur, Karger, Amy B., Eckfeldt, John H., Kasiske, Bertram L., Mauer, Michael, Navis, Gerjan, Poggio, Emilio D., Rossing, Peter, Shlipak, Michael G., and Levey, Andrew S.

Published
2021
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8. Thyroid function in end stage renal disease and effects of frequent hemodialysis

Author

Lo, Joan C, Beck, Gerald J, Kaysen, George A, Chan, Christopher T, Kliger, Alan S, Rocco, Michael V, Li, Minwei, Chertow, Glenn M, and Study, for the FHN

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Assistive Technology, Kidney Disease, Clinical Research, Bioengineering, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Metabolic and endocrine, Aged, Female, Humans, Hypothyroidism, Kidney Failure, Chronic, Male, Middle Aged, Renal Dialysis, Thyroid Function Tests, Thyroid Gland, FHN Study, End-stage renal disease, daily dialysis, hypothyroidism, nocturnal dialysis, thyroid, Urology & Nephrology, Clinical sciences
Abstract

IntroductionEnd-stage renal disease (ESRD) is associated with perturbations in thyroid hormone concentrations and an increased prevalence of hypothyroidism. Few studies have examined the effects of hemodialysis dose or frequency on endogenous thyroid function.MethodsWithin the Frequent Hemodialysis Network (FHN) trials, we examined the prevalence of hypothyroidism in patients with ESRD. Among those with endogenous thyroid function (without overt hyper/hypothyroidism or thyroid hormone supplementation), we examined the association of thyroid hormone concentration with multiple parameters of self-reported health status, and physical and cognitive performance, and the effects of hemodialysis frequency on serum thyroid stimulating hormone (TSH), free thyroxine (FT4), and free tri-iodothyronine (FT3) levels. Conventional thrice-weekly hemodialysis was compared to in-center (6 d/wk) hemodialysis (Daily Trial) and Nocturnal (6 nights/wk) home hemodialysis (Nocturnal Trial) over 12 months.FindingsAmong 226 FHN Trial participants, the prevalence of hypothyroidism was 11% based on thyroid hormone treatment and/or serum TSH ≥8 mIU/mL. Among the remaining 195 participants (147 Daily, 48 Nocturnal) with endogenous thyroid function, TSH concentrations were modestly (directly) correlated with age (r = 0.16, P = 0.03) but not dialysis vintage. Circulating thyroid hormone levels were not associated with parameters of health status or physical and cognitive performance. Furthermore, frequent in-center and nocturnal hemodialysis did not significantly change (baseline to month 12) TSH, FT4, or FT3 concentrations in patients with endogenous thyroid function.DiscussionAmong patients receiving hemodialysis without overt hyper/hypothyroidism or thyroid hormone treatment, thyroid indices were not associated with multiple measures of health status and were not significantly altered with increased dialysis frequency.

Published
2017

9. Hyperprolactinemia in end‐stage renal disease and effects of frequent hemodialysis

Author

Lo, Joan C, Beck, Gerald J, Kaysen, George A, Chan, Christopher T, Kliger, Alan S, Rocco, Michael V, Chertow, Glenn M, and Study, for the FHN

Subjects
Bioengineering, Prevention, Clinical Research, Kidney Disease, Assistive Technology, Clinical Trials and Supportive Activities, Renal and urogenital, Good Health and Well Being, Female, Humans, Hyperprolactinemia, Kidney Failure, Chronic, Male, Middle Aged, Quality of Life, Renal Dialysis, FHN Study, Prolactin, daily dialysis, end stage renal disease, nocturnal dialysis, pituitary, Clinical Sciences, Urology & Nephrology
Abstract

IntroductionEnd-stage renal disease is associated with elevations in circulating prolactin concentrations, but the association of prolactin concentrations with intermediate health outcomes and the effects of hemodialysis frequency on changes in serum prolactin have not been examined.MethodsThe FHN Daily and Nocturnal Dialysis Trials compared the effects of conventional thrice weekly hemodialysis with in-center daily hemodialysis (6 days/week) and nocturnal home hemodialysis (6 nights/week) over 12 months and obtained measures of health-related quality of life, self-reported physical function, mental health and cognition. Serum prolactin concentrations were measured at baseline and 12-month follow-up in 70% of the FHN Trial cohort to examine the associations among serum prolactin concentrations and physical, mental and cognitive function and the effects of hemodialysis frequency on serum prolactin.FindingsAmong 177 Daily Trial and 60 Nocturnal Trial participants with baseline serum prolactin measurements, the median serum prolactin concentration was 65 ng/mL (25th-75th percentile 48-195 ng/mL) and 81% had serum prolactin concentrations >30 ng/mL. While serum prolactin was associated with sex (higher in women), we observed no association between baseline serum prolactin and age, dialysis vintage, and baseline measures of physical, mental and cognitive function. Furthermore, there was no significant effect of hemodialysis frequency on serum prolactin in either of the two trials.DiscussionSerum prolactin concentrations were elevated in the large majority of patients with ESRD, but were not associated with several measures of health status. Circulating prolactin levels also do not appear to decrease in response to more frequent hemodialysis over a one-year period.

Published
2017

11. Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes

Author

Courcoulas, Anita P., primary, Patti, Mary Elizabeth, additional, Hu, Bo, additional, Arterburn, David E., additional, Simonson, Donald C., additional, Gourash, William F., additional, Jakicic, John M., additional, Vernon, Ashley H., additional, Beck, Gerald J., additional, Schauer, Philip R., additional, Kashyap, Sangeeta R., additional, Aminian, Ali, additional, Cummings, David E., additional, and Kirwan, John P., additional

Published
2024
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12. Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials

Author

Sevillano, Angel, Kamper, Anne-Lise, van Zuilen, Arjan D., Brenner, Barry M., Maes, Bart, Ihle, Benno U., Barret, Brendan, Leung, CB, Szeto, CC, Fitzner, Christina, Wanner, Christoph, Pozzi, Claudio, Montagnino, Claudio Ponticelli, Xie, Di, de Zeeuw, Dick, Lewis, Edmund, Verde, Eduardo, Gutierrez, Eduardo, Imai, Enyu, Hou, Fan Fan, Caravaca, Fernando, Fervenza, Fernando C., Locatelli, Francesco, Schena, Francesco Paolo, Kobayashi, Fumiaki, Moroni, Gabriella, Becker, Gavin J., Beck, Gerald J., Appel, Gerald B., Frisch, Gershon, van Essen, GG, Maschio, Giuseppe, Remuzzi, Giuseppe, Montogrino, Giuseppe, Parving, Hans-Henrik, Heerspink, Hiddo J.L., Makino, Hirofumi, Jehan, Imitiaz, Wetzels, Jack F.M., Donadio, James, Dwyer, Jamie, van den Brand, Jan, Kusek, John, Lachin, John M., Luño, Jose, Lewis, Julia B., Floege, Jürgen, Abebe, Kaleab Z., Chow, KM, Hunsicker, Lawrence G., del Vecchio, Lucia, Carlo, Manno, Praga, Manuel, Goicoechea, Marian, von Eynatten, Maximilian, Poulter, Neil, Chaturvedi, Nish, Passerini, Patrizia, de Jong, Paul E., Blankestijn, Peter J., Li, Philip, Ruggenenti, Piero, Zucchelli, Pietro, Kincaid-Smith, Priscilla S., Hilgers, Ralf-Dieter, Estacio, Raymond O., Rohde, Richard D., Katafuchi, Ritsuko, Toto, Robert D., Schrier, Robert W., Rodby, Roger A., Perrone, Ronald D., Ito, Sadayoshi, Klahr, Saulo, Andrulli, Simeone, Strandgaard, Svend, Chan, Tak Mao, Hannedouche, Thierry P., Rauen, Thomas, Greene, Tom, Verdalles, Ursula, Perkovic, Vlado, Keane, William, Heerspink, Hiddo J L, Tighiouart, Hocine, Gansevoort, Ron T, Coresh, Josef, Simon, Andrew L, Lewis, Julia B, Levey, Andrew S, and Inker, Lesley A

Published
2019
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14. Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension

Author

Lowery, Megan M., primary, Hill, Nicholas S., additional, Wang, Lu, additional, Rosenzweig, Erika B., additional, Bhat, Aparna, additional, Erzurum, Serpil, additional, Finet, J. Emanuel, additional, Jellis, Christine L., additional, Kaur, Sunjeet, additional, Kwon, Deborah H., additional, Nawabit, Rawan, additional, Radeva, Milena, additional, Beck, Gerald J., additional, Frantz, Robert P., additional, Hassoun, Paul M., additional, Hemnes, Anna R., additional, Horn, Evelyn M., additional, Leopold, Jane A., additional, Rischard, Franz P., additional, Mehra, Reena, additional, Hill, N., additional, Xiao, L., additional, Fu, Y.-P., additional, Postow, L., additional, Schmetter, B., additional, Stanton, K., additional, Tian, X., additional, Gray, M., additional, Wong, B., additional, Leopold, J., additional, Waxman, A., additional, DiCarli, M., additional, Lawler, L., additional, Maron, B., additional, Segrera, S., additional, Systrom, D., additional, Yu, P., additional, Rosenzweig, E.B., additional, Arcasoy, S., additional, Brady, D., additional, Chung, W., additional, Payne, D., additional, Grunig, G., additional, Haythe, J., additional, Krishnan, U., additional, Horn, E., additional, Akat, K., additional, Borczuk, A., additional, Devereux, R., additional, Gordon, J., additional, Kaner, R., additional, Karas, M., additional, Min, J., additional, Narula, N., additional, Ricketts, M., additional, Sobol, I., additional, Spiera, R., additional, Singh, H., additional, Tuschl, T., additional, Weinsaft, J., additional, Hassoun, P., additional, Mathai, S., additional, Barnes, K., additional, Damico, R., additional, Enobun, B., additional, Gao, L., additional, Halushka, M., additional, Kass, D., additional, Kolb, T., additional, Lin, T., additional, Tedford, R., additional, Zimmerman, S., additional, Frantz, R., additional, Behfar, A., additional, Block, L., additional, Borlaug, B., additional, Durst, L., additional, Foley, T., additional, Hammer, T., additional, Johnson, B., additional, Johnson, G., additional, Kane, G., additional, Krowka, M., additional, McNallan, A., additional, Olson, T., additional, Redfield, M., additional, Rohwer, K., additional, Terzic, A., additional, Williamson, E., additional, Rischard, F., additional, Yuan, J., additional, Abidov, A., additional, Garcia, J., additional, Cordery, A., additional, Desai, A., additional, Erickson, H., additional, Hansen, L., additional, Khalpey, Z., additional, Knox, K., additional, Lussier, Y., additional, Simon, M., additional, Vanderpool, R., additional, Hemnes, A., additional, Newman, J., additional, Austin, E., additional, Brittain, E., additional, Cunningham, J., additional, LaRochelle, C., additional, Pugh, M., additional, Robbins, I., additional, Wheeler, L., additional, Beck, G., additional, Erzurum, S., additional, Aldred, M., additional, Asosingh, K., additional, Barnard, J., additional, Collart, C., additional, Comhair, S., additional, DiFilippo, F., additional, Drinko, J., additional, Dweik, R., additional, Flinn, A., additional, Geraci, M., additional, Hu, B., additional, Jaber, W., additional, Jacob, M., additional, Jellis, C., additional, Kalhan, S., additional, Kassimatis, K., additional, Kirsop, J., additional, Koo, M., additional, Kwon, D., additional, Larive, B., additional, Lempel, J., additional, Li, M., additional, MacKrell, J., additional, Matuska, B., additional, McCarthy, K., additional, Mehra, R., additional, Neumann, D., additional, Nawabit, R., additional, Olman, M., additional, Park, M., additional, Radeva, M., additional, Sharp, J., additional, Sherer, S., additional, Tang, W., additional, Thomas, J., additional, Wiggins, K., additional, Willard, B., additional, Rounds, S., additional, Benza, R., additional, Bull, T., additional, Cadigan, J., additional, Fang, J., additional, Gomberg-Maitland, M., additional, and Page, G., additional

Published
2023
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15. Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension

Author

Simpson, Catherine E., primary, Ambade, Anjira S., additional, Harlan, Robert, additional, Roux, Aurelie, additional, Aja, Susan, additional, Graham, David, additional, Shah, Ami A., additional, Hummers, Laura K., additional, Hemnes, Anna R., additional, Leopold, Jane A., additional, Horn, Evelyn M., additional, Berman-Rosenzweig, Erika S., additional, Grunig, Gabrielle, additional, Aldred, Micheala A., additional, Barnard, John, additional, Comhair, Suzy A.A., additional, Tang, W. H. Wilson, additional, Griffiths, Megan, additional, Rischard, Franz, additional, Frantz, Robert P., additional, Erzurum, Serpil C., additional, Beck, Gerald J., additional, Hill, Nicholas S., additional, Mathai, Stephen C., additional, Hassoun, Paul M., additional, and Damico, Rachel L., additional

Published
2023
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19. Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in CKD

Author

Appel, Lawrence J., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob, Liu, Xun, Foster, Meredith C., Tighiouart, Hocine, Anderson, Amanda H., Beck, Gerald J., Contreras, Gabriel, Coresh, Josef, Eckfeldt, John H., Feldman, Harold I., Greene, Tom, Hamm, L. Lee, Horwitz, Edward, Lewis, Julia, Ricardo, Ana C., Shou, Haochang, Townsend, Raymond R., Weir, Matthew R., Inker, Lesley A., and Levey, Andrew S.

Published
2016
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20. GFR Estimation Using β-Trace Protein and β2-Microglobulin in CKD

Author

Inker, Lesley A., Tighiouart, Hocine, Coresh, Josef, Foster, Meredith C., Anderson, Amanda H., Beck, Gerald J., Contreras, Gabriel, Greene, Tom, Karger, Amy B., Kusek, John W., Lash, James, Lewis, Julia, Schelling, Jeffrey R., Navaneethan, Sankar D., Sondheimer, James, Shafi, Tariq, and Levey, Andrew S.

Published
2016
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21. Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension

Author

Rischard, Franz P., primary, Bernardo, Roberto J., additional, Vanderpool, Rebecca R., additional, Kwon, Deborah H., additional, Acharya, Tushar, additional, Park, Margaret M, additional, Katrynuik, Austin, additional, Insel, Michael, additional, Kubba, Saad, additional, Badagliacca, Roberto, additional, Larive, A Brett, additional, Naeije, Robert, additional, Garcia, Joe G.N., additional, Beck, Gerald J, additional, Erzurum, Serpil C, additional, Frantz, Robert P, additional, Hassoun, Paul M, additional, Hemnes, Anna R, additional, Hill, Nicholas S, additional, Horn, Evelyn M, additional, Leopold, Jane A, additional, Rosenzweig, Erika B., additional, Tang, W.H. Wilson, additional, and Wilcox, Jennifer D., additional

Published
2023
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25. Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation

Author

Li, Yingnan, primary, He, Yong, additional, Falzon, Isabelle, additional, Fairbourn, Brayden, additional, Tingey, Spencer, additional, Imrey, Peter B., additional, Radeva, Milena K., additional, Beck, Gerald J., additional, Gassman, Jennifer J., additional, Roy-Chaudhury, Prabir, additional, Berceli, Scott A., additional, Cheung, Alfred K., additional, Shiu, Yan-Ting, additional, Feldman, H., additional, Dember, L., additional, Farber, A., additional, Kaufman, J., additional, Stern, L., additional, LeSage, P., additional, Kivork, C., additional, Soares, D., additional, Malikova, M., additional, Allon, M., additional, Young, C., additional, Taylor, M., additional, Woodard, L., additional, Mangadi, K., additional, Roy-Chaudhury, P., additional, Munda, R., additional, Lee, T., additional, Alloway, R., additional, El-Khatib, M., additional, Canaan, T., additional, Pflum, A., additional, Thieken, L., additional, Campos-Naciff, B., additional, Huber, T., additional, Berceli, S., additional, Jansen, M., additional, McCaslin, G., additional, Trahan, Y., additional, Vazquez, M., additional, Vongpatanasin, W., additional, Davidson, I., additional, Hwang, C., additional, Lightfoot, T., additional, Livingston, C., additional, Valencia, A., additional, Dolmatch, B., additional, Fenves, A., additional, Hawkins, N., additional, Cheung, A., additional, Kraiss, L., additional, Kinikini, D., additional, Treiman, G., additional, Ihnat, D., additional, Sarfati, M., additional, Lavasani, I., additional, Maloney, M., additional, Schlotfeldt, L., additional, Himmelfarb, J., additional, Buchanan, C., additional, Clark, C., additional, Crawford, C., additional, Hamlett, J., additional, Kundzins, J., additional, Manahan, L., additional, Wise, J., additional, Beck, G., additional, Gassman, J., additional, Greene, T., additional, Imrey, P., additional, Li, L., additional, Alster, J., additional, Li, M., additional, MacKrell, J., additional, Radeva, M., additional, Weiss, B., additional, Wiggins, K., additional, Alpers, C., additional, Hudkins, K., additional, Wietecha, T., additional, Robbin, M., additional, Umphrey, H., additional, Alexander, L., additional, Abts, C., additional, Belt, L., additional, Vita, J., additional, Hamburg, N., additional, Duess, M., additional, Levit, A., additional, Higgins, H., additional, Ke, S., additional, Mandaci, O., additional, Snell, C., additional, Gravley, J., additional, Behnken, S., additional, Mortensen, R., additional, Chertow, G., additional, Besarab, A., additional, Brayman, K., additional, Diener-West, M., additional, Harrison, D., additional, Inker, L., additional, Louis, T., additional, McClellan, W., additional, Rubin, J., additional, Kusek, J., additional, and Star, R., additional

Published
2022
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26. Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease

Author

Hemnes, Anna R., primary, Leopold, Jane A., additional, Radeva, Milena K., additional, Beck, Gerald J., additional, Abidov, Aiden, additional, Aldred, Micheala A., additional, Barnard, John, additional, Rosenzweig, Erika B., additional, Borlaug, Barry A., additional, Chung, Wendy K., additional, Comhair, Suzy A.A., additional, Desai, Ankit A., additional, Dubrock, Hilary M., additional, Erzurum, Serpil C., additional, Finet, J. Emanuel, additional, Frantz, Robert P., additional, Garcia, Joe G.N., additional, Geraci, Mark W., additional, Gray, Michael P., additional, Grunig, Gabriele, additional, Hassoun, Paul M., additional, Highland, Kristin B., additional, Hill, Nicholas S., additional, Hu, Bo, additional, Kwon, Deborah H., additional, Jacob, Miriam S., additional, Jellis, Christine L., additional, Larive, A. Brett, additional, Lempel, Jason K., additional, Maron, Bradley A., additional, Mathai, Stephen C., additional, McCarthy, Kevin, additional, Mehra, Reena, additional, Nawabit, Rawan, additional, Newman, John H., additional, Olman, Mitchell A., additional, Park, Margaret M., additional, Ramos, Jose A., additional, Renapurkar, Rahul D., additional, Rischard, Franz P., additional, Sherer, Susan G., additional, Tang, W.H. Wilson, additional, Thomas, James D., additional, Vanderpool, Rebecca R., additional, Waxman, Aaron B., additional, Wilcox, Jennifer D., additional, Yuan, Jason X.-J., additional, and Horn, Evelyn M., additional

Published
2022
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27. Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation

Author

Feldman, H., Dember, L., Farber, A., Kaufman, J., Stern, L., LeSage, P., Kivork, C., Soares, D., Malikova, M., Allon, M., Young, C., Taylor, M., Woodard, L., Mangadi, K., Roy-Chaudhury, P., Munda, R., Lee, T., Alloway, R., El-Khatib, M., Canaan, T., Pflum, A., Thieken, L., Campos-Naciff, B., Huber, T., Berceli, S., Jansen, M., McCaslin, G., Trahan, Y., Vazquez, M., Vongpatanasin, W., Davidson, I., Hwang, C., Lightfoot, T., Livingston, C., Valencia, A., Dolmatch, B., Fenves, A., Hawkins, N., Cheung, A., Kraiss, L., Kinikini, D., Treiman, G., Ihnat, D., Sarfati, M., Lavasani, I., Maloney, M., Schlotfeldt, L., Himmelfarb, J., Buchanan, C., Clark, C., Crawford, C., Hamlett, J., Kundzins, J., Manahan, L., Wise, J., Beck, G., Gassman, J., Greene, T., Imrey, P., Li, L., Alster, J., Li, M., MacKrell, J., Radeva, M., Weiss, B., Wiggins, K., Alpers, C., Hudkins, K., Wietecha, T., Robbin, M., Umphrey, H., Alexander, L., Abts, C., Belt, L., Vita, J., Hamburg, N., Duess, M., Levit, A., Higgins, H., Ke, S., Mandaci, O., Snell, C., Gravley, J., Behnken, S., Mortensen, R., Chertow, G., Besarab, A., Brayman, K., Diener-West, M., Harrison, D., Inker, L., Louis, T., McClellan, W., Rubin, J., Kusek, J., Star, R., Li, Yingnan, He, Yong, Falzon, Isabelle, Fairbourn, Brayden, Tingey, Spencer, Imrey, Peter B., Radeva, Milena K., Beck, Gerald J., Gassman, Jennifer J., Roy-Chaudhury, Prabir, Berceli, Scott A., Cheung, Alfred K., and Shiu, Yan-Ting

Published
2022
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28. PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics

Author

Hemnes, Anna R., Beck, Gerald J., Newman, John H., Abidov, Aiden, Aldred, Micheala A., Barnard, John, Berman Rosenzweig, Erika, Borlaug, Barry A., Chung, Wendy K., Comhair, Suzy A.A., Erzurum, Serpil C., Frantz, Robert P., Gray, Michael P., Grunig, Gabriele, Hassoun, Paul M., Hill, Nicholas S., Horn, Evelyn M., Hu, Bo, Lempel, Jason K., Maron, Bradley A., Mathai, Stephen C., Olman, Mitchell A., Rischard, Franz P., Systrom, David M., Tang, W.H. Wilson, Waxman, Aaron B., Xiao, Lei, Yuan, Jason X.-J., and Leopold, Jane A.

Published
2017
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29. Histopathology of Veins Obtained at Hemodialysis Arteriovenous Fistula Creation Surgery

Author

Alpers, Charles E., Imrey, Peter B., Hudkins, Kelly L., Wietecha, Tomasz A., Radeva, Milena, Allon, Michael, Cheung, Alfred K., Dember, Laura M., Roy-Chaudhury, Prabir, Shiu, Yan-Ting, Terry, Christi M., Farber, Alik, Beck, Gerald J., Feldman, Harold I., Kusek, John W., Himmelfarb, Jonathan, Dember, LM, Imrey, PB, Beck, GJ, Cheung, AK, Himmelfarb, J, Huber, TS, Kusek, JW, Roy-Chaudhury, P, Vazquez, MA, Alpers, CE, Robbin, ML, Vita, JA, Greene, T, Gassman, JJ, and Feldman, HI

Published
2017
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31. The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial

Author

Rocco, Michael V., Lockridge, Robert S., Jr., Beck, Gerald J., Eggers, Paul W., Gassman, Jennifer J., Greene, Tom, Larive, Brett, Chan, Christopher T., Chertow, Glenn M., Copland, Michael, Hoy, Christopher D., Lindsay, Robert M., Levin, Nathan W., Ornt, Daniel B., Pierratos, Andreas, Pipkin, Mary F., Rajagopalan, Sanjay, Stokes, John B., Unruh, Mark L., Star, Robert A., and Kliger, Alan S.

Published
2011
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35. Supplemental Material, sj-pdf-1-ojs-10.1177_23259671211065447 - Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial

Author

Spindler, Kurt P., Imrey, Peter B., Yalcin, Sercan, Beck, Gerald J., Calbrese, Gary, Cox, Charles L., Fadale, Paul D., Farrow, Lutul, Fitch, Robert, Flanigan, David, Fleming, Braden C., Hulstyn, Michael J., Jones, Morgan H., Kaeding, Christopher, Katz, Jeffrey N., Kriz, Peter, Magnussen, Robert, McErlean, Ellen, Melgaard, Carrie, Owens, Brett D., Saluan, Paul, Strnad, Greg, Winalski, Carl S., and Wright, Rick

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110314 Orthopaedics
Abstract

Supplemental Material, sj-pdf-1-ojs-10.1177_23259671211065447 for Design Features and Rationale of the BEAR-MOON (Bridge-Enhanced ACL Restoration Multicenter Orthopaedic Outcomes Network) Randomized Clinical Trial by BEAR-MOON Design Group, Kurt P. Spindler, Peter B. Imrey, Sercan Yalcin, Gerald J. Beck, Gary Calbrese, Charles L. Cox, Paul D. Fadale, Lutul Farrow, Robert Fitch, David Flanigan, Braden C. Fleming, Michael J. Hulstyn, Morgan H. Jones, Christopher Kaeding, Jeffrey N. Katz, Peter Kriz, Robert Magnussen, Ellen McErlean, Carrie Melgaard, Brett D. Owens, Paul Saluan, Greg Strnad, Carl S. Winalski and Rick Wright in Orthopaedic Journal of Sports Medicine

Published
2022
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39. Arteriovenous Fistula Maturation, Functional Patency, and Intervention Rates

Author

Huber, Thomas S., primary, Berceli, Scott A., additional, Scali, Salvatore T., additional, Neal, Dan, additional, Anderson, Erik M., additional, Allon, Michael, additional, Cheung, Alfred K., additional, Dember, Laura M., additional, Himmelfarb, Jonathan, additional, Roy-Chaudhury, Prabir, additional, Vazquez, Miguel A., additional, Alpers, Charles E., additional, Robbin, Michelle L., additional, Imrey, Peter B., additional, Beck, Gerald J., additional, Farber, Alik M., additional, Kaufman, James S., additional, Kraiss, Larry W., additional, Vongpatanasin, Wanpen, additional, Kusek, John W., additional, and Feldman, Harold I., additional

Published
2021
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41. A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas

Author

Baron, John A., Barry, Elizabeth L., Mott, Leila A., Rees, Judy R., Sandler, Robert S., Snover, Dale C., Bostick, Roberd M., Ivanova, Anastasia, Cole, Bernard F., Ahnen, Dennis J., Beck, Gerald J., Bresalier, Robert S., Burke, Carol A., Church, Timothy R., Cruz-Correa, Marcia, Figueiredo, Jane C., Goodman, Michael, Kim, Adam S., Robertson, Douglas J., Rothstein, Richard, Shaukat, Aasma, Seabrook, March E., and Summers, Robert W.

Published
2015
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46. Ultrasound-guided Percutaneous Cryoneurolysis to Treat Chronic Postamputation Phantom Limb Pain: A Multicenter Randomized Controlled Trial.

Author

Ilfeld, Brian M., Smith, Cameron R., Turan, Alparslan, Mariano, Edward R., Miller, Matthew E., Fisher, Rick L., Trescot, Andrea M., Cohen, Steven P., Eisenach, James C., Sessler, Daniel I., Prologo, J. David, Mascha, Edward J., Liu, Liu, Gabriel, Rodney A., Hayek, Salim M., Wadhwa, Anupama N., Beck, Gerald J., Abdullah, Baharin, Esa, Wael Ali Sakr, and Altinpulluk, Ece Yamak

Published
2023
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50. NEW DIALYSIS TECHNIQUES

Author

Kliger, Alan S, Chertow, Glenn M, Levin, Nathan W, Beck, Gerald J, Daugirdas, John T, Eggers, Paul W, Larive, Brett, Rocco, Michael V, and Greene, Tom

Published
2014

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