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Technology has paved the way for new modalities in language learning, teaching, and assessment. However, there is still a great deal of work to be done to develop such tools for oral communication, specifically tools that address suprasegmental features in pronunciation instruction. Therefore, this critical literature review examines how researchers have tried to create computer-assisted pronunciation training tools using automatic speech recognition (ASR) systems to aid language learners in the perception and production of suprasegmental features. We used 30 texts from 1990 to 2020 to explore how technologies have been and are currently being used to help learners develop their proficiency with suprasegmental features. Based on our thematic analysis, a persistent gap still exists between ASR-equipped software available to participants in research studies and what is available to university and classroom teachers and students. Additionally, there seems to be more development in the production of speech software for language assessment. In contrast, the translation of these tools into instructional tools for individualized learning seems to be almost non-existent. Moving forward, we recommend that more commercialized pronunciation systems utilizing ASR should be made publicly available using the technologies that are currently developed or are in development for the purposes of oral proficiency judgments.

BackgroundThis study investigated the relationship between smoking and hearing loss and deafness (HLD) and whether the relationship is modified by genetic variation. Data for these analyses was from the subset of Japanese American families collected as part of the American Diabetes Association Genetics of Non-insulin Dependent Diabetes Mellitus study. Logistic regression with generalized estimating equations assessed the relationship between HLD and smoking. Nonparametric linkage analysis identified genetic regions harboring HLD susceptibility genes and ordered subset analysis was used to identify regions showing evidence for gene-smoking interactions. Genetic variants within these candidate regions were then each tested for interaction with smoking using logistic regression models.ResultsAfter adjusting for age, sex, diabetes status and smoking duration, for each pack of cigarettes smoked per day, risk of HLD increased 4.58 times (odds ratio (OR) = 4.58; 95% Confidence Interval (CI): (1.40,15.03)), and ever smokers were over 5 times more likely than nonsmokers to report HLD (OR = 5.22; 95% CI: (1.24, 22.03)). Suggestive evidence for linkage for HLD was observed in multiple genomic regions (Chromosomes 5p15, 8p23 and 17q21), and additional suggestive regions were identified when considering interactions with smoking status (Chromosomes 7p21, 11q23, 12q32, 15q26, and 20q13) and packs-per-day (Chromosome 8q21).ConclusionsTo our knowledge this was the first report of possible gene-by-smoking interactions in HLD using family data. Additional work, including independent replication, is needed to understand the basis of these findings. HLD are important public health issues and understanding the contributions of genetic and environmental factors may inform public health messages and policies.

The COVID-19 pandemic pushed the Iowa State University administration to impose face coverings and other safety regulations across the university campus. To comply with these safety measures, several changes to the English Placement Test of Oral Communication (EPT OC) had to be made. This paper discusses how the EPT OC was adapted to comply with the safety regulations mandated by the university administration and best ensure the safety of students and raters. It also describes the different considerations that were made prior to implementing these adaptations, and our thoughts while administering and rating the test. The paper concludes with what might be learned from administering the OC test during the pandemic.

IntroductionThe etiology of familial breast cancer is complex and involves genetic and environmental factors such as hormonal and lifestyle factors. Understanding familial aggregation is a key to understanding the causes of breast cancer and to facilitating the development of effective prevention and therapy. To address urgent research questions and to expedite the translation of research results to the clinical setting, the National Cancer Institute (USA) supported in 1995 the establishment of a novel research infrastructure, the Breast Cancer Family Registry, a collaboration of six academic and research institutions and their medical affiliates in the USA, Canada, and Australia.MethodsThe sites have developed core family history and epidemiology questionnaires, data dictionaries, and common protocols for biospecimen collection and processing and pathology review. An Informatics Center has been established to collate, manage, and distribute core data.ResultsAs of September 2003, 9116 population-based and 2834 clinic-based families have been enrolled, including 2346 families from minority populations. Epidemiology questionnaire data are available for 6779 affected probands (with a personal history of breast cancer), 4116 unaffected probands, and 16,526 relatives with or without a personal history of breast or ovarian cancer. The biospecimen repository contains blood or mouthwash samples for 6316 affected probands, 2966 unaffected probands, and 10,763 relatives, and tumor tissue samples for 4293 individuals.ConclusionThis resource is available to internal and external researchers for collaborative, interdisciplinary, and translational studies of the genetic epidemiology of breast cancer. Detailed information can be found at the URL http://www.cfr.epi.uci.edu/.

Technology has paved the way for new modalities in language learning, teaching, and assessment. However, there is still a great deal of work to be done to develop such tools for oral communication, specifically tools that address suprasegmental features in pronunciation instruction. Therefore, this critical literature review examines how researchers have tried to create computer-assisted pronunciation training tools using automatic speech recognition (ASR) systems to aid language learners in the perception and production of suprasegmental features. We used 30 texts from 1990 to 2020 to explore how technologies have been and are currently being used to help learners develop their proficiency with suprasegmental features. Based on our thematic analysis, a persistent gap still exists between ASR-equipped software available to participants in research studies and what is available to university and classroom teachers and students. Additionally, there seems to be more development in the production of speech software for language assessment. In contrast, the translation of these tools into instructional tools for individualized learning seems to be almost non-existent. Moving forward, we recommend that more commercialized pronunciation systems utilizing ASR should be made publicly available using the technologies that are currently developed or are in development for the purposes of oral proficiency judgments. [ABSTRACT FROM AUTHOR]

As a particular field within the discipline of Canadian history, women's organizations have only recently been accepted as a topic of major research importance. Even more rare was any extensive [...]

Background: To identify genetic associations of quantitative metabolic syndrome (MetS) traits and characterize heterogeneity across ethnic groups. Methods: Data was collected from GENetics of Noninsulin dependent Diabetes Mellitus (GENNID), a multiethnic resource of Type 2 diabetic families and included 1520 subjects in 259 African-American, European-American, Japanese-Americans, and Mexican-American families. We focused on eight MetS traits: weight, waist circumference, systolic and diastolic blood pressure, high-density lipoprotein, triglycerides, fasting glucose, and insulin. Using genotyped and imputed data from Illumina's Multiethnic array, we conducted genome-wide association analyses with linear mixed models for all ethnicities, except for the smaller Japanese-American group, where we used additive genetic models with gene-dropping. Results: Findings included ethnic-specific genetic associations and heterogeneity across ethnicities. Most significant associations were outside our candidate linkage regions and were coincident within a gene or intergenic region, with two exceptions in European-American families: (a) within previously identified linkage region on chromosome 2, two significant GLI2-TFCP2L1 associations with weight, and (b) one chromosome 11 variant near CADM1-LINC00900 with pleiotropic blood pressure effects. Conclusions: This multiethnic family study found genetic heterogeneity and coincident associations (with one case of pleiotropy), highlighting the importance of including diverse populations in genetic research and illustrating the complex genetic architecture underlying MetS. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic pushed the Iowa State University administration to impose face coverings and other safety regulations across the university campus. To comply with these safety measures, several changes to the English Placement Test of Oral Communication (EPT OC) had to be made. This paper discusses how the EPT OC was adapted to comply with the safety regulations mandated by the university administration and best ensure the safety of students and raters. It also describes the different considerations that were made prior to implementing these adaptations, and our thoughts while administering and rating the test. The paper concludes with what might be learned from administering the OC test during the pandemic. [ABSTRACT FROM AUTHOR]

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Comments on an article on the evaluation of replicative senescence in culture as a model for cell aging. Role of cell culture studies for research on aging; Estimated proliferative life span exhibited by cultures from young women; Relationship between replicative life span of fibroblasts in culture.