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2. Fibrohistiozytäre Tumoren

Author

Beham, Alfred, Schneider-Stock, Regine, Cardesa, Antonio, editor, Rudolph, Pierre, editor, Mentzel, Thomas, editor, and Slootweg, Pieter J., editor

Published
2009
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30. Clusterin expression in elastofibroma dorsi

Author

Aigelsreite, Ariane, Pichler, Martin, Pixner, Thomas, Janig, Elke, Schuller, Monika, Lackner, Carolin, Scheipl, Susanne, Beham, Alfred, and Regauer, Sigrid

Subjects
Tumorigenesis, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], sense organs, Immunohistochemistry, eye diseases
Abstract

Background: Elastofibroma dorsi is a benign soft tissue lesion composed of abnormal elastic fibers. Degenerated elastic fibers in skin and liver are associated with clusterin, an apoprotein that shares functional properties with small heat shock proteins. We evaluated the staining pattern and possible role of clusterin in elastofibroma dorsi. Material and methods: Twenty-one subcutaneous elastofibromas from the scapular region were evaluated with Elastica van Gieson and Orcein stains, immunohistochemically with antibodies to clusterin, smooth muscle actin, S-100, vimentin and CD34 and correlated with clinical data with respect to physical trauma. Results: Clusterin correlated with the staining pattern of Elastica van Gieson and labelled abnormal broad coarse fibrillar and globular elastic fibers in all elastofibromas. Orcein stains additionally identified fine oxytalan fibers which were not stained by clusterin. Clusterin staining was observed only on the outside of the elastin fibers, while the cores of fibers and globules were unstained. 4/21 elastofibromas showed cellular nodules with a myxoid/ collagenous stroma. The round to oval cells showed cytoplasmic staining with vimentin and clusterin; CD34 labelled mostly cell membranes. The cells lacked SMA and S-100 expression. The central areas of the nodules were devoid of elastic fibers, but the periphery contained coarse fibers and globules. 9/11 patients, for whom clinical data were available, reported trauma to the scapular region. Conclusion: Many investigated ED were associated with trauma, which supports a reactive/ degenerative etiology of ED. The abnormal large elastic fibers in all ED were enveloped by clusterin. Clusterin deposition may protect elastic fibers from degradation and thus contribute indirectly to the tumor-like presentation of ED.

Published
2013

39. Epulis: a study of 92 cases with special emphasis on histopathological diagnosis and associated clinical data.

Author

Truschnegg, Astrid, Acham, Stephan, Kiefer, Birgit, Jakse, Norbert, and Beham, Alfred

Subjects
HISTOPATHOLOGY, FIBROMAS, ORAL surgery, ORAL hygiene, RADIOLOGY, DIAGNOSIS
Abstract

Objectives: Aim of the present study was clinical and histopathological evaluation of a series of epulides to provide clinicians data to frequency distribution and biological behaviour of different underlying entities. Materials and methods: Ninety-two cases of epulides removed by CO-laser at the Department of Oral Surgery and Radiology, Medical University of Graz from 2000 to 2014 were studied retrospectively for clinical data and histopathological diagnosis. Results: In the presented study, histopathological examination revealed peripheral ossifying fibroma (32.6 %), fibroma/fibrosis (29.3 %), giant cell lesion (13.1 %) and granuloma pyogenicum (8.7 %) as the most frequent underlying entities. For the first time, hyperplastic squamous epithelium (7.6 %), granulation tissue (5.4 %) and peripheral odontogenic fibromas (3.3 %) were detected to clinically appear as epulides. Irrespective of the histological diagnosis, the mean age in our patients was 43.8 years. The majority of the lesions were found in the frontal region of both jaws. In all cases, the patients showed poor oral hygiene, local gingivitis and some of them an occlusal trauma. Conclusions: To identify different entities with different biological behaviour, to exclude malignant tumours and to identify new entities among epulides, histopathological examination is required. Poor oral hygiene and occlusal trauma seem to play an important role in the pathogenesis and could be risk factors for recurrences. Clinical relevance: Frequency distribution of different entities in epulides is provided to clinicians, and new histopathological entities were detected to clinically appear as epulides. [ABSTRACT FROM AUTHOR]

Published
2016
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41. Expression of Ezrin, MMP-9, and COX-2 in 50 Chordoma Specimens

Author

Froehlich, Elke Verena, primary, Scheipl, Susanne, additional, Lazàry, Aron, additional, Varga, Peter Pal, additional, Schmid, Christoph, additional, Stammberger, Heinz, additional, Beham, Alfred, additional, Bodo, Koppany, additional, Schroettner, Heribert, additional, Quehenberger, Franz, additional, Windhager, Reinhard, additional, Liegl, Bernadette, additional, and Leithner, Andreas, additional

Published
2012
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44. Chlamydia psittaci Infection in Nongastrointestinal Extranodal MALT Lymphomas and Their Precursor Lesions

Author

Aigelsreiter, Ariane, primary, Gerlza, Tanja, additional, Deutsch, Alexander J.A., additional, Leitner, Eva, additional, Beham-Schmid, Christine, additional, Beham, Alfred, additional, Popper, Helmut, additional, Borel, Nicole, additional, Pospischil, Andreas, additional, Raderer, Markus, additional, Kessler, Harald H., additional, and Neumeister, Peter, additional

Published
2011
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48. Low telomerase activity: Possible role in the progression of human medullary thyroid carcinoma

Author

Stadler, Guido, primary, Wieser, Matthias, additional, Streubel, Berthold, additional, Stift, Anton, additional, Friedl, Josef, additional, Gnant, Michael, additional, Niederle, Bruno, additional, Beham, Alfred, additional, Katinger, Hermann, additional, Pfragner, Roswitha, additional, Grillari, Johannes, additional, and Voglauer, Regina, additional

Published
2008
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49. Is Wide Resection Obsolete for Desmoid Tumors in Children and Adolescents? Evaluation of Histological Margins, Immunohistochemical Markers, and Review of Literature.

Author

Woltsche, Nora, Gilg, Magdalena M., Fraissler, Lukas, Liegl-Atzwanger, Bernadette, Beham, Alfred, Lackner, Herwig, Benesch, Martin, and Leithner, Andreas

Subjects
MUCINOUS adenocarcinoma, TUMORS in children, JUVENILE diseases, CHILDHOOD cancer, NEPHROBLASTOMA
Abstract

Desmoid fibromatosis is a benign fibroblastic neoplasm with high recurrence rates predominantly observed in pediatric and adolescent patients. The use of wide resection margins has been discussed controversially in literature. In addition, data on non-surgical treatment is limited as phase III studies are still missing. Nineteen patients under the age of 18 years were identified. Tumor location, surgical treatment for primary or recurrent tumors, resection margins, medical neo-/adjuvant treatment, time to recurrence as well as immunohistochemical markers (estrogen receptor, ER α and β, progesterone and androgen receptors, somatostatin, Ki-67, c-kit, platelet-derived growth factor receptors, PDGFRs, α and β, β-catenin) were evaluated. The mean age at diagnosis was 6.6 years, with a mean follow-up of 114 months. Recurrences were detected in four out of nineteen patients. Surprisingly, the recurrence rate was not influenced by type of resection used (R0, R1/2). All samples were tested negative for ER α, somatostatin, and progesterone receptor. In contrast, a majority of tumors showed positive results for PDGFR α and β and β-catenin. No correlation between positive immunohistochemical markers and tumor recurrences was detectable. In conclusion, recurrence rates are not depending on resection type and immunohistochemical markers seem to behave differently in children and adolescents in contrast to adult patients. [ABSTRACT FROM AUTHOR]

Published
2015
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50. MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation

Author

Deutsch, Alexander J. A., primary, Aigelsreiter, Ariane, additional, Staber, Philipp B., additional, Beham, Alfred, additional, Linkesch, Werner, additional, Guelly, Christian, additional, Brezinschek, Ruth I., additional, Fruhwirth, Margareta, additional, Emberger, Werner, additional, Buettner, Maike, additional, Beham-Schmid, Christine, additional, and Neumeister, Peter, additional

Published
2006
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