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In addition to taste and melting behavior, the gloss is an important quality criterion of chocolate products. Differences considering the gloss on products can be attributed to different causes in the production process. The chocolate that has been pre‐crystallized by shearing and supercooling is further cooled, crystallized and transported as a solid chocolate out of the cooling process. The cooling of the chocolate is largely unexplored in a paternoster refrigerator and therefore the resulting streaming profile and temperature profile are numerically studied in this work. [ABSTRACT FROM AUTHOR]

In addition to taste and melting behavior, the gloss is an important quality criterion of chocolate products. Differences considering the gloss on products can be attributed to different causes in the production process. The chocolate which has been precrystallized by shearing and supercooling is further cooled, crystallized, and transported as a solid chocolate out of the cooling process. The cooling of the chocolate is largely unexplored in a paternoster refrigerator. Therefore, the resulting flow profile and temperature profile are numerically studied in this work. [ABSTRACT FROM AUTHOR]

We study a class of homotopies between maps from 4-manifolds to surfaces which we call cusp merges. These homotopies naturally appear in the uniqueness problems for certain pictorial descriptions of 4-manifolds derived from maps to the 2-sphere (for example, broken Lefschetz fibrations, wrinkled fibrations, or Morse 2-functions). Our main results provide a classification of cusp merge homotopies in terms of suitably framed curves in the source manifold, as well as a fairly explicit description of a parallel transport diffeomorphism associated to a cusp merge homotopy. The latter is the key ingredient in understanding how the aforementioned pictorial descriptions change under homotopies involving cusp merges. We apply our methods to the uniqueness problem of surface diagrams of 4-manifolds and describe algorithms to obtain surface diagrams for total spaces of (achiral) Lefschetz fibrations and 4-manifolds of the form M × S1, where M is a 3-manifold. Along the way we provide extensive background material about maps to surfaces and homotopies thereof and develop a theory of parallel transport that generalizes the use of gradient flows in Morse theory [ABSTRACT FROM AUTHOR]

Describes the synthesis of three cyclic phosphopeptides and the nuclear magnetic resonance (NMR) structural analysis of one its congeners. Preparation of precursors for macrocyclization by phospitylation; Oxidation and hydrogenolysis; Solution conformation analysis via NMR spectroscopy and molecular dynamics calculations.

Left bundle brunch block (LBBB) and right ventricular stimulation (RVS) may be associated with asynchrony and heart failure. Differences between these two entities and their response to cardiac resynchronization therapy (CRT) are not well defined. Patients receiving CRT from 1999 to 2006 were analyzed for cardiac events and prognosis separated between primary implants for LBBB (n = 221) and upgrades from RVS (n = 107). A subgroup of 105 patients (LBBB = 69; RVS = 36) was studied in more detail (New York Heart Association [NYHA], quality of life, brain natriuretic peptide, peakVO2, left ventricular ejection fraction [LVEF], wedge pressure, Cardiac Index, QRS, left-right preejection period using pulsed wave doppler, septum-lateral wall motion delay using tissue doppler imaging) at baseline and after 1 year. Age (68.4 ± 11 years vs 68.7 ± 15 years, n. s.), NYHA class (3.1 vs 3.1, n. s.), LVEF (26.4 vs 28.1, n. s.), and clinical parameters were comparable between LBBB and RVS. The latter group consisted of more patients with chronic atrial fibrillation (14% vs 37%, P = 0.03). After 1 year, NYHA class (−0.8 ± 0.8 vs −0.6 ± 0.8, n. s.), LVEF (+13.7 ± 14% vs +8.7 ± 10%, n. s.), and clinical parameters improved similarly. After a median follow-up of 2.33 ± 1.8 years in the LBBB versus 2.43 ± 1.9 years in the RVS group, there was no difference in long-term prognosis or cardiac events in the total cohort (5-year event rate, 53% vs 55%, P = n. s.). Upgrade patients showed similar baseline parameters and response to CRT as to primary implants. No difference in events or long-term prognosis could be observed. [ABSTRACT FROM AUTHOR]

Cardiac Resynchronization therapy (CRT) using coronary sinus (CS) leads is an established method for the therapy of congestive heart failure (CHF) in the case of inter- and intraventricular conduction delays. However implantation of CS leads is somewhat challenging due to a high number of peri- or postoperative dislocations at a rate of about 10%. The retained guidewire technique has been proposed for the implantation of coronary sinus leads for stabilization in case of repetitive intraoperative dislocations. This report describes CS lead and guidewire fracture 2 years after such an implant. [ABSTRACT FROM AUTHOR]