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3. Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo

Author

Benvenuto, Monica, Angiolini, Valentina, Focaccetti, Chiara, Nardozi, Daniela, Palumbo, Camilla, Carrano, Raffaele, Rufini, Alessandra, Bei, Riccardo, Miele, Martino Tony, Mancini, Patrizia, Barillari, Giovanni, Cirone, Mara, Ferretti, Elisabetta, Tundo, Grazia Raffaella, Mutti, Luciano, Masuelli, Laura, and Bei, Roberto

Published
2023
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5.  Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo

Author

Bei, Roberto, Benvenuto, Monica, Focaccetti, Chiara, Fazi, Sara, Moretti, Marta, Nardozi, Daniela, Angiolini, Valentina, Ciuffa, Sara, Cifaldi, Loredana, Carrano, Raffaele, Palumbo, Camilla, Miele, Martino Tony, Bei, Riccardo, Barillari, Giovanni, Manzari, Vittorio, De Smaele, Enrico, Modesti, Andrea, and Masuelli, Laura

Published
2022
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6. Bisphenol-A in Drinking Water Accelerates Mammary Cancerogenesis and Favors an Immunosuppressive Tumor Microenvironment in BALB–neuT Mice

Author

Focaccetti, Chiara, primary, Nardozi, Daniela, additional, Benvenuto, Monica, additional, Lucarini, Valeria, additional, Angiolini, Valentina, additional, Carrano, Raffaele, additional, Scimeca, Manuel, additional, Servadei, Francesca, additional, Mauriello, Alessandro, additional, Mancini, Patrizia, additional, Besharat, Zein Mersini, additional, Milella, Michele, additional, Migliaccio, Silvia, additional, Ferretti, Elisabetta, additional, Cifaldi, Loredana, additional, Masuelli, Laura, additional, Palumbo, Camilla, additional, and Bei, Roberto, additional

Published
2024
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7. Characterization of Natural Killer Cell Profile in a Cohort of Infected Pregnant Women and Their Babies and Its Relation to CMV Transmission

Author

Pighi, Chiara, primary, Rotili, Arianna, additional, De Luca, Maia, additional, Chiurchiù, Sara, additional, Calò Carducci, Francesca Ippolita, additional, Rossetti, Chiara, additional, Cifaldi, Loredana, additional, Bei, Roberto, additional, Caforio, Leonardo, additional, Bernardi, Stefania, additional, Palma, Paolo, additional, and Amodio, Donato, additional

Published
2024
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10. Study of genotoxic and cytotoxic effects induced in human fibroblasts by exposure to pulsed and continuous 1.6 GHz radiofrequency.

Author

Massaro, Luca, De Sanctis, Stefania, Franchini, Valeria, Regalbuto, Elisa, Alfano, Gaetano, Focaccetti, Chiara, Benvenuto, Monica, Cifaldi, Loredana, Sgura, Antonella, Berardinelli, Francesco, Marinaccio, Jessica, Barbato, Federica, Rossi, Erica, Nardozi, Daniela, Masuelli, Laura, Bei, Roberto, and Lista, Florigio

Published
2024
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11. Biomarkers Identification in the Microenvironment of Oral Squamous Cell Carcinoma: A Systematic Review of Proteomic Studies.

Author

Pomella, Silvia, Melaiu, Ombretta, Cifaldi, Loredana, Bei, Roberto, Gargari, Marco, Campanella, Vincenzo, and Barillari, Giovanni

Subjects
EXTRACELLULAR matrix proteins, SQUAMOUS cell carcinoma, TUMOR microenvironment, ENERGY metabolism, MASS spectrometry
Abstract

An important determinant for oral squamous cell carcinoma (OSCC) onset and outcome is the composition of the tumor microenvironment (TME). Thus, the study of the interactions occurring among cancer cells, immune cells, and cancer-associated fibroblasts within the TME could facilitate the understanding of the mechanisms underlying OSCC development and progression, as well as of its sensitivity or resistance to the therapy. In this context, it must be highlighted that the characterization of TME proteins is enabled by proteomic methodologies, particularly mass spectrometry (MS). Aiming to identify TME protein markers employable for diagnosing and prognosticating OSCC, we have retrieved a total of 119 articles spanning 2001 to 2023, of which 17 have passed the selection process, satisfying all its criteria. We have found a total of 570 proteins detected by MS-based proteomics in the TME of OSCC; among them, 542 are identified by a single study, while 28 are cited by two or more studies. These 28 proteins participate in extracellular matrix remodeling and/or energy metabolism. Here, we propose them as markers that could be used to characterize the TME of OSCC for diagnostic/prognostic purposes. Noteworthy, most of the 28 individuated proteins share one feature: being modulated by the hypoxia that is present in the proliferating OSCC mass. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Dietary Polyphenols Effects on Focal Adhesion Plaques and Metalloproteinases in Cancer Invasiveness

Author

Carrano, Raffaele, primary, Grande, Martina, additional, Leti Maggio, Eleonora, additional, Zucca, Carlotta, additional, Bei, Riccardo, additional, Palumbo, Camilla, additional, Focaccetti, Chiara, additional, Nardozi, Daniela, additional, Lucarini, Valeria, additional, Angiolini, Valentina, additional, Mancini, Patrizia, additional, Barberini, Francesca, additional, Barillari, Giovanni, additional, Cifaldi, Loredana, additional, Masuelli, Laura, additional, Benvenuto, Monica, additional, and Bei, Roberto, additional

Published
2024
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15. Bisphenol-A in Drinking Water Accelerates Mammary Cancerogenesis and Favors an Immunosuppressive Tumor Microenvironment in BALB– neu T Mice.

Author

Focaccetti, Chiara, Nardozi, Daniela, Benvenuto, Monica, Lucarini, Valeria, Angiolini, Valentina, Carrano, Raffaele, Scimeca, Manuel, Servadei, Francesca, Mauriello, Alessandro, Mancini, Patrizia, Besharat, Zein Mersini, Milella, Michele, Migliaccio, Silvia, Ferretti, Elisabetta, Cifaldi, Loredana, Masuelli, Laura, Palumbo, Camilla, and Bei, Roberto

Subjects
TUMOR microenvironment, BISPHENOL A, BREAST, BIOMARKERS, DRINKING water, ENDOCRINE disruptors, ESTROGEN receptors
Abstract

Bisphenol-A (BPA), a synthetic compound ubiquitously present in the environment, can act as an endocrine disruptor by binding to both canonical and non-canonical estrogen receptors (ERs). Exposure to BPA has been linked to various cancers, in particular, those arising in hormone-targeted tissues such as the breast. In this study, we evaluated the effect of BPA intake through drinking water on ErbB2/neu-driven cancerogenesis in BALB–neuT mice, transgenic for a mutated ErbB2/neu receptor gene, which reproducibly develop carcinomas in all mammary glands. In this model, BPA accelerated mammary cancerogenesis with an increase in the number of tumors per mouse and a concurrent decrease in tumor-free and overall survival. As assessed by immunohistochemistry, BALB–neuT tumors were ER-negative but expressed high levels of the alternative estrogen receptor GPR30, regardless of BPA exposure. On the other hand, BPA exposure resulted in a marked upregulation of progesterone receptors in preinvasive tumors and of Ki67, CD31, and phosphorylated Akt in invasive tumors. Moreover, based on several infiltration markers of immune cells, BPA favored an immunosuppressive tumor microenvironment. Finally, in vitro cell survival studies performed on a cell line established from a BALB–neuT breast carcinoma confirmed that BPA's impact on cancer progression can be particularly relevant after chronic, low-dose exposure. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival

Author

Focaccetti, Chiara, primary, Palumbo, Camilla, additional, Benvenuto, Monica, additional, Carrano, Raffaele, additional, Melaiu, Ombretta, additional, Nardozi, Daniela, additional, Angiolini, Valentina, additional, Lucarini, Valeria, additional, Kërpi, Bora, additional, Masuelli, Laura, additional, Cifaldi, Loredana, additional, and Bei, Roberto, additional

Published
2023
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17. The endocrine disruptor cadmium modulates the androgen–estrogen receptors ratio and induces inflammatory cytokines in luminal (A) cell models of breast cancer

Author

Bimonte, Viviana M., primary, Catanzaro, Giuseppina, additional, Po, Agnese, additional, Trocchianesi, Sofia, additional, Besharat, Zein Mersini, additional, Spinello, Zaira, additional, Curreli, Mariaignazia, additional, Fabi, Alessandra, additional, Bei, Roberto, additional, Milella, Michele, additional, Vacca, Alessandra, additional, Ferretti, Elisabetta, additional, and Migliaccio, Silvia, additional

Published
2023
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18. Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in Mitophagy

Author

Foglio, Eleonora, primary, D’Avorio, Erica, additional, Vitiello, Laura, additional, Masuelli, Laura, additional, Bei, Roberto, additional, Pacifici, Francesca, additional, Della-Morte, David, additional, Mirabilii, Simone, additional, Ricciardi, Maria Rosaria, additional, Tafuri, Agostino, additional, Garaci, Enrico, additional, Russo, Matteo Antonio, additional, Tafani, Marco, additional, and Limana, Federica, additional

Published
2023
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20. Curcumin potentiates the ErbB receptors inhibitor Afatinib for enhanced antitumor activity in malignant mesothelioma

Author

Benvenuto, Monica, primary, Nardozi, Daniela, additional, Palumbo, Camilla, additional, Focaccetti, Chiara, additional, Carrano, Raffaele, additional, Angiolini, Valentina, additional, Cifaldi, Loredana, additional, Lucarini, Valeria, additional, Mancini, Patrizia, additional, Kërpi, Bora, additional, Currenti, Walter, additional, Bei, Roberto, additional, and Masuelli, Laura, additional

Published
2023
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21. The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival.

Author

Focaccetti, Chiara, Palumbo, Camilla, Benvenuto, Monica, Carrano, Raffaele, Melaiu, Ombretta, Nardozi, Daniela, Angiolini, Valentina, Lucarini, Valeria, Kërpi, Bora, Masuelli, Laura, Cifaldi, Loredana, and Bei, Roberto

Subjects
MONONUCLEAR leukocytes, CANCER cells, REGULATORY T cells, IMMUNE response, CELL survival
Abstract

The polyphenols Curcumin (CUR) and Resveratrol (RES) are widely described for their antitumoral effects. However, their low bioavailability is a drawback for their use in therapy. The aim of this study was to explore whether CUR and RES, used at a bioavailable concentration, could modulate immune responses while retaining antitumor activity and to determine whether CUR and RES effects on the immune responses of peripheral blood mononuclear cells (PBMCs) and tumor growth inhibition could be improved by their combination. We demonstrate that the low-dose combination of CUR and RES reduced the survival of cancer cell lines but had no effect on the viability of PBMCs. Although following CUR + RES treatment T lymphocytes showed an enhanced activated state, RES counteracted the increased IFN-γ expression induced by CUR in T cells and the polyphenol combination increased IL-10 production by T regulatory cells. On the other hand, the combined treatment enhanced NK cell activity through the up- and downregulation of activating and inhibitory receptors and increased CD68 expression levels on monocytes/macrophages. Overall, our results indicate that the combination of CUR and RES at low doses differentially shapes immune cells while retaining antitumor activity, support the use of this polyphenol combinations in anticancer therapy and suggest its possible application as adjuvant for NK cell-based immunotherapies. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Biological Effects of 25 to 150 GHz Radiation After In Vitro Exposure of Human Fibroblasts: a Comparison of Experimental Results

Author

Franchini, Valeria, Ceccuzzi, Silvio, Doria, Andrea, Gallerano, Gian Piero, Giovenale, Emilio, Ravera, Gian Luca, De Amicis, Andrea, De Sanctis, Stefania, Di Cristofaro, Sara, Regalbuto, Elisa, Coluzzi, Elisa, Marinaccio, Jessica, Sgura, Antonella, Bei, Roberto, Benvenuto, Monica, Modesti, Andrea, Masuelli, Laura, and Lista, Florigio

Published
2018
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26. Supplementary Video 1 from Nutlin-3a Enhances Natural Killer Cell–Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors

Author

Veneziani, Irene, primary, Infante, Paola, primary, Ferretti, Elisa, primary, Melaiu, Ombretta, primary, Battistelli, Cecilia, primary, Lucarini, Valeria, primary, Compagnone, Mirco, primary, Nicoletti, Carmine, primary, Castellano, Aurora, primary, Petrini, Stefania, primary, Ognibene, Marzia, primary, Pezzolo, Annalisa, primary, Di Marcotullio, Lucia, primary, Bei, Roberto, primary, Moretta, Lorenzo, primary, Pistoia, Vito, primary, Fruci, Doriana, primary, Barnaba, Vincenzo, primary, Locatelli, Franco, primary, and Cifaldi, Loredana, primary

Published
2023
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27. Supplementary Figures from Nutlin-3a Enhances Natural Killer Cell–Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors

Author

Veneziani, Irene, primary, Infante, Paola, primary, Ferretti, Elisa, primary, Melaiu, Ombretta, primary, Battistelli, Cecilia, primary, Lucarini, Valeria, primary, Compagnone, Mirco, primary, Nicoletti, Carmine, primary, Castellano, Aurora, primary, Petrini, Stefania, primary, Ognibene, Marzia, primary, Pezzolo, Annalisa, primary, Di Marcotullio, Lucia, primary, Bei, Roberto, primary, Moretta, Lorenzo, primary, Pistoia, Vito, primary, Fruci, Doriana, primary, Barnaba, Vincenzo, primary, Locatelli, Franco, primary, and Cifaldi, Loredana, primary

Published
2023
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28. Data from Nutlin-3a Enhances Natural Killer Cell–Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors

Author

Veneziani, Irene, primary, Infante, Paola, primary, Ferretti, Elisa, primary, Melaiu, Ombretta, primary, Battistelli, Cecilia, primary, Lucarini, Valeria, primary, Compagnone, Mirco, primary, Nicoletti, Carmine, primary, Castellano, Aurora, primary, Petrini, Stefania, primary, Ognibene, Marzia, primary, Pezzolo, Annalisa, primary, Di Marcotullio, Lucia, primary, Bei, Roberto, primary, Moretta, Lorenzo, primary, Pistoia, Vito, primary, Fruci, Doriana, primary, Barnaba, Vincenzo, primary, Locatelli, Franco, primary, and Cifaldi, Loredana, primary

Published
2023
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29. Supplementary Table 1 from Nutlin-3a Enhances Natural Killer Cell–Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors

Author

Veneziani, Irene, primary, Infante, Paola, primary, Ferretti, Elisa, primary, Melaiu, Ombretta, primary, Battistelli, Cecilia, primary, Lucarini, Valeria, primary, Compagnone, Mirco, primary, Nicoletti, Carmine, primary, Castellano, Aurora, primary, Petrini, Stefania, primary, Ognibene, Marzia, primary, Pezzolo, Annalisa, primary, Di Marcotullio, Lucia, primary, Bei, Roberto, primary, Moretta, Lorenzo, primary, Pistoia, Vito, primary, Fruci, Doriana, primary, Barnaba, Vincenzo, primary, Locatelli, Franco, primary, and Cifaldi, Loredana, primary

Published
2023
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30. Supplementary Figure legend from Nutlin-3a Enhances Natural Killer Cell–Mediated Killing of Neuroblastoma by Restoring p53-Dependent Expression of Ligands for NKG2D and DNAM-1 Receptors

Author

Veneziani, Irene, primary, Infante, Paola, primary, Ferretti, Elisa, primary, Melaiu, Ombretta, primary, Battistelli, Cecilia, primary, Lucarini, Valeria, primary, Compagnone, Mirco, primary, Nicoletti, Carmine, primary, Castellano, Aurora, primary, Petrini, Stefania, primary, Ognibene, Marzia, primary, Pezzolo, Annalisa, primary, Di Marcotullio, Lucia, primary, Bei, Roberto, primary, Moretta, Lorenzo, primary, Pistoia, Vito, primary, Fruci, Doriana, primary, Barnaba, Vincenzo, primary, Locatelli, Franco, primary, and Cifaldi, Loredana, primary

Published
2023
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31. Different outcome of targeting ERN1/IRE1 alpha and EIF2AK3/PERK in NSG mice engrafted with primary effusion lymphoma

Author

Arena, Andrea, primary, Romeo, Maria Anele, additional, Focaccetti, Chiara, additional, Anastasiadou, Eleni, additional, Trivedi, Pankaj, additional, Cifaldi, Loredana, additional, Gilardini Montani, Maria Saveria, additional, Benedetti, Rossella, additional, Santarelli, Roberta, additional, Gonnella, Roberta, additional, Benvenuto, Monica, additional, Marchese, Cinzia, additional, Masuelli, Laura, additional, Bei, Roberto, additional, and Cirone, Mara, additional

Published
2023
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32. The Combination of Immune Checkpoint Blockade with Tumor Vessel Normalization as a Promising Therapeutic Strategy for Breast Cancer: An Overview of Preclinical and Clinical Studies

Author

Melaiu, Ombretta, primary, Vanni, Gianluca, additional, Portarena, Ilaria, additional, Pistolese, Chiara Adriana, additional, Anemona, Lucia, additional, Pomella, Silvia, additional, Bei, Roberto, additional, Buonomo, Oreste Claudio, additional, Roselli, Mario, additional, Mauriello, Alessandro, additional, and Barillari, Giovanni, additional

Published
2023
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33. Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma

Author

Palumbo, Camilla, primary, Benvenuto, Monica, additional, Focaccetti, Chiara, additional, Albonici, Loredana, additional, Cifaldi, Loredana, additional, Rufini, Alessandra, additional, Nardozi, Daniela, additional, Angiolini, Valentina, additional, Bei, Arianna, additional, Masuelli, Laura, additional, and Bei, Roberto, additional

Published
2023
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37. Mechanistic Insights into the Superior DNA Delivery Efficiency of Multicomponent Lipid Nanoparticles: An In Vitro and In Vivo Study

Author

Quagliarini, Erica, primary, Wang, Junbiao, additional, Renzi, Serena, additional, Cui, Lishan, additional, Digiacomo, Luca, additional, Ferri, Gianmarco, additional, Pesce, Luca, additional, De Lorenzi, Valentina, additional, Matteoli, Giulia, additional, Amenitsch, Heinz, additional, Masuelli, Laura, additional, Bei, Roberto, additional, Pozzi, Daniela, additional, Amici, Augusto, additional, Cardarelli, Francesco, additional, Marchini, Cristina, additional, and Caracciolo, Giulio, additional

Published
2022
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40. New insights into the Bortezomib‐induced cytotoxic and resistance mechanisms in a primary effusion lymphoma mouse model.

Author

Romeo, Maria Anele, Focaccetti, Chiara, Arena, Andrea, Benedetti, Rossella, Di Crosta, Michele, Palumbo, Camilla, Gilardini Montani, Maria Saveria, Santarelli, Roberta, Gonnella, Roberta, D'Orazi, Gabriella, Bei, Roberto, and Cirone, Mara

Subjects
BORTEZOMIB, EXUDATES & transudates, LABORATORY mice, ANIMAL disease models, KAPOSI'S sarcoma-associated herpesvirus, DNA repair
Abstract

This article discusses the use of the drug Bortezomib in the treatment of primary effusion lymphoma (PEL), a type of non-Hodgkin B cell lymphoma associated with Kaposi's sarcoma-associated herpesvirus (KSHV). The current standard chemotherapy for PEL only provides partial remission in a small percentage of patients. Bortezomib has shown cytotoxic effects against PEL cells in vitro and in mice, prolonging survival and preventing ascites formation. The study also explores the potential of combining Bortezomib with Chloroquine, but the results show a reduction in the therapeutic effect. The findings provide new insights into the mechanisms of Bortezomib and highlight the importance of understanding these mechanisms to improve treatment outcomes for PEL. [Extracted from the article]

Published
2024
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41. Efficient Delivery of DNA Using Lipid Nanoparticles

Author

Cui, Lishan, primary, Renzi, Serena, additional, Quagliarini, Erica, additional, Digiacomo, Luca, additional, Amenitsch, Heinz, additional, Masuelli, Laura, additional, Bei, Roberto, additional, Ferri, Gianmarco, additional, Cardarelli, Francesco, additional, Wang, Junbiao, additional, Amici, Augusto, additional, Pozzi, Daniela, additional, Marchini, Cristina, additional, and Caracciolo, Giulio, additional

Published
2022
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43. DNAM-1-chimeric receptor-engineered NK cells, combined with Nutlin-3a, more effectively fight neuroblastoma cells in vitro: a proof-of-concept study

Author

Focaccetti, Chiara, primary, Benvenuto, Monica, additional, Pighi, Chiara, additional, Vitelli, Alessandra, additional, Napolitano, Federico, additional, Cotugno, Nicola, additional, Fruci, Doriana, additional, Palma, Paolo, additional, Rossi, Paolo, additional, Bei, Roberto, additional, and Cifaldi, Loredana, additional

Published
2022
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48. De novo DHDDS variants cause a neurodevelopmental and neurodegenerative disorder with myoclonus

Author

Genetica Klinische Genetica, Brain, Child Health, Galosi, Serena, Edani, Ban H, Martinelli, Simone, Hansikova, Hana, Eklund, Erik A, Caputi, Caterina, Masuelli, Laura, Corsten-Janssen, Nicole, Srour, Myriam, Oegema, Renske, Bosch, Daniëlle G M, Ellis, Colin A, Amlie-Wolf, Louise, Accogli, Andrea, Atallah, Isis, Averdunk, Luisa, Barañano, Kristin W, Bei, Roberto, Bagnasco, Irene, Brusco, Alfredo, Demarest, Scott, Alaix, Anne-Sophie, Di Bonaventura, Carlo, Distelmaier, Felix, Elmslie, Frances, Gan-Or, Ziv, Good, Jean-Marc, Gripp, Karen, Kamsteeg, Erik-Jan, Macnamara, Ellen, Marcelis, Carlo, Mercier, Noëlle, Peeden, Joseph, Pizzi, Simone, Pannone, Luca, Shinawi, Marwan, Toro, Camilo, Verbeek, Nienke E, Venkateswaran, Sunita, Wheeler, Patricia G, Zdrazilova, Lucie, Zhang, Rong, Zorzi, Giovanna, Guerrini, Renzo, Sessa, William C, Lefeber, Dirk, Tartaglia, Marco, Hamdan, Fadi F, Grabińska, Kariona A, Leuzzi, Vincenzo, Genetica Klinische Genetica, Brain, Child Health, Galosi, Serena, Edani, Ban H, Martinelli, Simone, Hansikova, Hana, Eklund, Erik A, Caputi, Caterina, Masuelli, Laura, Corsten-Janssen, Nicole, Srour, Myriam, Oegema, Renske, Bosch, Daniëlle G M, Ellis, Colin A, Amlie-Wolf, Louise, Accogli, Andrea, Atallah, Isis, Averdunk, Luisa, Barañano, Kristin W, Bei, Roberto, Bagnasco, Irene, Brusco, Alfredo, Demarest, Scott, Alaix, Anne-Sophie, Di Bonaventura, Carlo, Distelmaier, Felix, Elmslie, Frances, Gan-Or, Ziv, Good, Jean-Marc, Gripp, Karen, Kamsteeg, Erik-Jan, Macnamara, Ellen, Marcelis, Carlo, Mercier, Noëlle, Peeden, Joseph, Pizzi, Simone, Pannone, Luca, Shinawi, Marwan, Toro, Camilo, Verbeek, Nienke E, Venkateswaran, Sunita, Wheeler, Patricia G, Zdrazilova, Lucie, Zhang, Rong, Zorzi, Giovanna, Guerrini, Renzo, Sessa, William C, Lefeber, Dirk, Tartaglia, Marco, Hamdan, Fadi F, Grabińska, Kariona A, and Leuzzi, Vincenzo

Published
2022

49. DNAM-1 chimeric receptor-engineered NK cells: a new frontier for CAR-NK cell-based immunotherapy.

Author

Cifaldi, Loredana, Melaiu, Ombretta, Giovannoni, Roberto, Benvenuto, Monica, Focaccetti, Chiara, Nardozi, Daniela, Barillari, Giovanni, and Bei, Roberto

Subjects
KILLER cells, ANTIGEN receptors, IMMUNOTHERAPY, CELL receptors, HEMATOLOGIC malignancies
Abstract

DNAM-1 is a major NK cell activating receptor and, together with NKG2D and NCRs, by binding specific ligands, strongly contributes to mediating the killing of tumor or virus-infected cells. DNAM-1 specifically recognizes PVR and Nectin-2 ligands that are expressed on some virus-infected cells and on a broad spectrum of tumor cells of both hematological and solid malignancies. So far, while NK cells engineered for different antigen chimeric receptors (CARs) or chimeric NKG2D receptor have been extensively tested in preclinical and clinical studies, the use of DNAM-1 chimeric receptor-engineered NK cells has been proposed only in our recent proof-of-concept study and deserves further development. The aim of this perspective study is to describe the rationale for using this novel tool as a new anti-cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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