Search

Your search keyword '"Bejar, R"' showing total 288 results
Start Over Author "Bejar, R"
288 results on '"Bejar, R"'

1. Topic: AS01-Diagnosis/AS01c-Molecular aberrations (cytogenetic, genetic, gene expression): GENOMIC CLASSIFICATION OF MYELODYSPLASTIC SYNDROMES

Author

Bernard, E., primary, Hasserjian, R., additional, Greenberg, P., additional, Ossa, J. Arango, additional, Creignou, M., additional, Nannya, Y., additional, Tuechler, H., additional, Medina-Martinez, J., additional, Levine, M., additional, Jädersten, M., additional, Germing, U., additional, Sanz, G., additional, Van De Loosdrecht, A., additional, Kosmider, O., additional, Follo, M., additional, Thol, F., additional, Zamora, L., additional, Pinheiro, R., additional, Pellagatti, A., additional, Elias, H., additional, Haase, D., additional, Ganster, C., additional, Ades, L., additional, Tobiasson, M., additional, Palomo, L., additional, Della Porta, M., additional, Fenaux, P., additional, Belickova, M., additional, Savona, M., additional, Klimek, V., additional, Santos, F., additional, Boultwood, J., additional, Kotsianidis, I., additional, Santini, V., additional, Solé, F., additional, Platzbecker, U., additional, Heuser, M., additional, Valent, P., additional, Finelli, C., additional, Voso, M.T., additional, Shih, L.-Y., additional, Fontenay, M., additional, Jansen, J., additional, Cervera-Zamora, J., additional, Gattermann, N., additional, Ebert, B., additional, Bejar, R., additional, Malcovati, L., additional, Cazzola, M., additional, Ogawa, S., additional, Hellstrom-Lindberg, E., additional, and Papaemmanuil, E., additional

Published
2023
Full Text
View/download PDF

2. Topic: AS03-Health Economics & Outcome Research/AS03a-Cost of care: ARE WE READY TO PERFORM NGS FOR ALL MDS PATIENTS ?

Author

Santini, V., primary, Bejar, R., additional, Belli, C., additional, Buckstein, R., additional, Campelo, M., additional, Dezern, A., additional, Fontenay, M., additional, Griffiths, E., additional, Grille, S., additional, Haferlach, T., additional, Iastrebner, M., additional, Kosmider, O., additional, Magalhaes, S., additional, Mittelman, M., additional, Platzbecker, U., additional, Wei, A., additional, and Zeidan, A., additional

Published
2023
Full Text
View/download PDF

4. P011 - Topic: AS01-Diagnosis/AS01c-Molecular aberrations (cytogenetic, genetic, gene expression): GENOMIC CLASSIFICATION OF MYELODYSPLASTIC SYNDROMES

Author

Bernard, E., Hasserjian, R., Greenberg, P., Ossa, J. Arango, Creignou, M., Nannya, Y., Tuechler, H., Medina-Martinez, J., Levine, M., Jädersten, M., Germing, U., Sanz, G., Van De Loosdrecht, A., Kosmider, O., Follo, M., Thol, F., Zamora, L., Pinheiro, R., Pellagatti, A., Elias, H., Haase, D., Ganster, C., Ades, L., Tobiasson, M., Palomo, L., Della Porta, M., Fenaux, P., Belickova, M., Savona, M., Klimek, V., Santos, F., Boultwood, J., Kotsianidis, I., Santini, V., Solé, F., Platzbecker, U., Heuser, M., Valent, P., Finelli, C., Voso, M.T., Shih, L.-Y., Fontenay, M., Jansen, J., Cervera-Zamora, J., Gattermann, N., Ebert, B., Bejar, R., Malcovati, L., Cazzola, M., Ogawa, S., Hellstrom-Lindberg, E., and Papaemmanuil, E.

Published
2023
Full Text
View/download PDF

5. Estimating the costs of an SDI-based project

Author

Nogueras-Iso, J., Béjar, R., Latre, M.A., Fernández-Villoslada, E., Muro-Medrano, P.R., Zarazaga-Soria, FJ., Cartwright, William, editor, Gartner, Georg, editor, Meng, Liqiu, editor, Peterson, Michael P., editor, Fabrikant, Sara Irina, editor, and Wachowicz, Monica, editor

Published
2007
Full Text
View/download PDF

10. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Author

Khoury, J.D., Solary, E., Abla, O., Akkari, Y., Alaggio, R., Apperley, J.F., Bejar, R., Berti, E., Busque, L., Chan, J.K.C., Chen, Weina, Chen, Xueyan, Chng, W.J., Choi, J.K., Colmenero, I., Coupland, S.E., Cross, N.C., Jong, Daphne de, Elghetany, M.T., Takahashi, E., Emile, J.F., Ferry, J., Fogelstrand, L., Fontenay, M., Germing, U., Gujral, S., Haferlach, T, Harrison, C., Hodge, J.C., Hu, S., Jansen, J.H., Kanagal-Shamanna, R., Kantarjian, H.M., Kratz, C.P., Li, X.Q., Lim, M.S.C., Loeb, K., Loghavi, S., Marcogliese, A., Meshinchi, S., Michaels, P., Naresh, K.N., Natkunam, Y., Nejati, R., Ott, G., Padron, E., Patel, K.P., Patkar, N., Picarsic, J., Platzbecker, U., Roberts, I., Schuh, A., Sewell, W., Siebert, R., Tembhare, P., Tyner, J., Verstovsek, S., Wang, W., Wood, B., Xiao, W., Yeung, C., Hochhaus, A., Khoury, J.D., Solary, E., Abla, O., Akkari, Y., Alaggio, R., Apperley, J.F., Bejar, R., Berti, E., Busque, L., Chan, J.K.C., Chen, Weina, Chen, Xueyan, Chng, W.J., Choi, J.K., Colmenero, I., Coupland, S.E., Cross, N.C., Jong, Daphne de, Elghetany, M.T., Takahashi, E., Emile, J.F., Ferry, J., Fogelstrand, L., Fontenay, M., Germing, U., Gujral, S., Haferlach, T, Harrison, C., Hodge, J.C., Hu, S., Jansen, J.H., Kanagal-Shamanna, R., Kantarjian, H.M., Kratz, C.P., Li, X.Q., Lim, M.S.C., Loeb, K., Loghavi, S., Marcogliese, A., Meshinchi, S., Michaels, P., Naresh, K.N., Natkunam, Y., Nejati, R., Ott, G., Padron, E., Patel, K.P., Patkar, N., Picarsic, J., Platzbecker, U., Roberts, I., Schuh, A., Sewell, W., Siebert, R., Tembhare, P., Tyner, J., Verstovsek, S., Wang, W., Wood, B., Xiao, W., Yeung, C., and Hochhaus, A.

Abstract

Contains fulltext : 282922.pdf (Publisher’s version ) (Open Access)

Published
2022

16. Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, and Papaemmanuil E

Published
2021

20. Life cycle assessment study of a 4.2kW.sub.p stand-alone photovoltaic system

Author

Garcia-Valverde, R., Miguel, C., Martinez-Bejar, R., and Urbina, A.

Subjects
Solar energy industry, Universities and colleges, Electric generators, Earth sciences, Petroleum, energy and mining industries
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.solener.2009.03.012 Byline: R. Garcia-Valverde (a), C. Miguel (a), R. Martinez-Bejar (b), A. Urbina (a) Keywords: Life cycle assessment; Stand-alone photovoltaic system; Energy pay-back time; CO.sub.2 emission factor Abstract: The energetic and environmental life cycle assessment of a 4.2kW.sub.p stand-alone photovoltaic system (SAPV) at the University of Murcia (south-east of Spain) is presented. PV modules and batteries are the energetically and environmentally most expensive elements. The energy pay-back time was found to be 9.08years and the specific CO.sub.2 emissions was calculated as 131g/kWh. The SAPV system has been environmentally compared with other supply options (diesel generator and Spanish grid) showing lower impacts in both cases. The results show the CO.sub.2-emission reduction potential of SAPV systems in southern European countries and point out the critical environmental issues in these systems. Author Affiliation: (a) Universidad Politecnica de Cartagena, Departamento de Electronica, Tecnologia de Computadoras y Proyectos, Campus Muralla del Mar, 30203, Cartagena, Murcia, Spain (b) Universidad de Murcia, Departamento de Ingenieria de la Informacion y las Comunicaciones, Facultad de Informatica, Campus de Espinardo, 30071, Murcia, Spain Article History: Received 27 February 2008; Revised 24 February 2009; Accepted 4 March 2009 Article Note: (miscellaneous) Communicated by: Associate Editor S.C. Bhattacharya

Published
2009

21. Implications ofTP53allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard, E, Nannya, Y, Hasserjian, RP, Devlin, SM, Tuechler, H, Medina-Martinez, JS, Yoshizato, T, Shiozawa, Y, Saiki, R, Malcovati, L, Levine, MF, Arango, JE, Zhou, YY, Sole, F, Cargo, CA, Haase, D, Creignou, M, Germing, U, Zhang, YM, Gundem, G, Sarian, A, van de Loosdrecht, AA, Jadersten, M, Tobiasson, M, Kosmider, O, Follo, MY, Thol, F, Pinheiro, RF, Santini, V, Kotsianidis, I, Boultwood, J, Santos, FPS, Schanz, J, Kasahara, S, Ishikawa, T, Tsurumi, H, Takaori-Kondo, A, Kiguchi, T, Polprasert, C, Bennett, JM, Klimek, VM, Savona, MR, Belickova, M, Ganster, C, Palomo, L, SANZ, G, Ades, L, Della Porta, MG, Smith, AG, Werner, Y, Patel, M, Viale, A, Vanness, K, Neuberg, DS, Stevenson, KE, Menghrajani, K, Bolton, KL, Fenaux, P, Pellagatti, A, Platzbecker, U, Heuser, M, Valent, P, Chiba, S, Miyazaki, Y, Finelli, C, Voso, MT, Shih, LY, Fontenay, M, Jansen, JH, Cervera, J, Atsuta, Y, Gattermann, N, Ebert, BL, Bejar, R, Greenberg, PL, Cazzola, M, Hellstrom-Lindberg, E, Ogawa, S, and Papaemmanuil, E

Abstract

Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states ofTP53and clinical presentation Tumor protein p53 (TP53) is the most frequently mutated gene in cancer(1,2). In patients with myelodysplastic syndromes (MDS),TP53mutations are associated with high-risk disease(3,4), rapid transformation to acute myeloid leukemia (AML)(5), resistance to conventional therapies(6-8)and dismal outcomes(9). Consistent with the tumor-suppressive role ofTP53, patients harbor both mono- and biallelic mutations(10). However, the biological and clinical implications ofTP53allelic state have not been fully investigated in MDS or any other cancer type. We analyzed 3,324 patients with MDS forTP53mutations and allelic imbalances and delineated two subsets of patients with distinct phenotypes and outcomes. One-third ofTP53-mutated patients had monoallelic mutations whereas two-thirds had multiple hits (multi-hit) consistent with biallelic targeting. Established associations with complex karyotype, few co-occurring mutations, high-risk presentation and poor outcomes were specific to multi-hit patients only.TP53multi-hit state predicted risk of death and leukemic transformation independently of the Revised International Prognostic Scoring System (IPSS-R)(11). Surprisingly, monoallelic patients did not differ fromTP53wild-type patients in outcomes and response to therapy. This study shows that consideration ofTP53allelic state is critical for diagnostic and prognostic precision in MDS as well as in future correlative studies of treatment response.

Published
2020

22. Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard, E., Nannya, Y., Hasserjian, R.P., Devlin, S.M., Tuechler, H., Medina-Martinez, J.S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M.F., Arango, J.E., Zhou, Y, Solé, F., Cargo, C.A., Haase, D., Creignou, M., Germing, U., Zhang, Y., Gundem, G., Sarian, A., Loosdrecht, A.A. van de, Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M.Y., Thol, F., Pinheiro, R.F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F.P.S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J.M., Klimek, V.M., Savona, M.R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Porta, M.G. Della, Smith, A.G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D.S., Stevenson, K.E., Menghrajani, K., Bolton, K.L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M.T., Shih, L.Y., Fontenay, M., Jansen, J.H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B.L., Bejar, R., Greenberg, P.L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S., Papaemmanuil, E., Bernard, E., Nannya, Y., Hasserjian, R.P., Devlin, S.M., Tuechler, H., Medina-Martinez, J.S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M.F., Arango, J.E., Zhou, Y, Solé, F., Cargo, C.A., Haase, D., Creignou, M., Germing, U., Zhang, Y., Gundem, G., Sarian, A., Loosdrecht, A.A. van de, Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M.Y., Thol, F., Pinheiro, R.F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F.P.S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J.M., Klimek, V.M., Savona, M.R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Porta, M.G. Della, Smith, A.G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D.S., Stevenson, K.E., Menghrajani, K., Bolton, K.L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M.T., Shih, L.Y., Fontenay, M., Jansen, J.H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B.L., Bejar, R., Greenberg, P.L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S., and Papaemmanuil, E.

Abstract

Contains fulltext : 229615.pdf (Publisher’s version ) (Closed access)

Published
2020

25. TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

Author

Haase, D, Stevenson, KE, Neuberg, D, Maciejewski, JP, Nazha, A, Sekeres, MA, Ebert, BL, Garcia-Manero, G, Haferlach, C, Haferlach, T, Kern, W, Ogawa, S, Nagata, Y, Yoshida, K, Graubert, TA, Walter, MJ, List, AF, Komrokji, RS, Padron, E, Sallman, D, Papaemmanuil, E, Campbell, PJ, Savona, MR, Seegmiller, A, Adès, L, Fenaux, P, Shih, L-Y, Bowen, D, Groves, MJ, Tauro, S, Fontenay, M, Kosmider, O, Bar-Natan, M, Steensma, D, Stone, R, Heuser, M, Thol, F, Cazzola, M, Malcovati, L, Karsan, A, Ganster, C, Hellström-Lindberg, E, Boultwood, J, Pellagatti, A, Santini, V, Quek, L, Vyas, P, Tüchler, H, Greenberg, PL, Bejar, R, and Committee, International Working Group For Mds Molecular Prognostic

Subjects
0301 basic medicine, Oncology, Male, Cancer Research, Tp53 mutation, medicine.disease_cause, 0302 clinical medicine, hemic and lymphatic diseases, 80 and over, Chromosome 7 (human), Aged, 80 and over, Mutation, Tumor, Karyotype, Hematology, Middle Aged, Prognosis, Combined Modality Therapy, myelodysplastic syndromes, 3. Good health, Survival Rate, 030220 oncology & carcinogenesis, Female, medicine.medical_specialty, Clinical Sciences, Oncology and Carcinogenesis, Immunology, and over, Article, 03 medical and health sciences, Rare Diseases, Internal medicine, Complex Karyotype, Genetics, medicine, Biomarkers, Tumor, Humans, Survival rate, Gene, Aged, TP53 mutation , myelodysplastic syndromes, Chromosome Aberrations, International Working Group for MDS Molecular Prognostic Committee, business.industry, Myelodysplastic syndromes, medicine.disease, 030104 developmental biology, Karyotyping, Myelodysplastic Syndromes, Tumor Suppressor Protein p53, business, Biomarkers, Follow-Up Studies
Abstract

Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS). Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic abnormalities, which is a highly adverse prognostic marker. However, CK-MDS can carry a wide range of chromosomal abnormalities and somatic mutations. To refine risk stratification of CK-MDS patients, we examined data from 359 CK-MDS patients shared by the International Working Group for MDS. Mutations were underrepresented with the exception of TP53 mutations, identified in 55% of patients. TP53 mutated patients had even fewer co-mutated genes but were enriched for the del(5q) chromosomal abnormality (p 10%), abnormal 3q, abnormal 9, and monosomy 7 as having the greatest survival risk. The poor risk associated with CK-MDS is driven by its association with prognostically adverse TP53 mutations and can be refined by considering clinical and karyotype features.

Published
2019

30. Supporting agent oriented requirement analysis with ontologies

Author

Lopez-Lorca, AA, Beydoun, G, Valencia-Garcia, R, Martinez-Bejar, R, Lopez-Lorca, AA, Beydoun, G, Valencia-Garcia, R, and Martinez-Bejar, R

Abstract

© 2015 Elsevier Ltd. All rights reserved. Requirements analysis activities underpin the success of the software development lifecycle. Subsequent errors in the requirements models can propagate to models in later phases and become much costlier to fix. Errors in requirement analysis are more likely in developing complex systems. Particularly, errors due to miscommunication and misinterpretation of a client's intentions are common. Ontologies relying on formal descriptions of semantics have often been used in multi agent systems (MAS) development to support various activities and generally improve the complex systems produced. However, their use during requirements analysis to validate match with the client's conceptualisation is largely unexplored. This article presents an ontology driven validation process to support requirement analysis of MAS models. This process is underpinned by an agent-based metamodel that describes commonly used informal agent requirement models. The process concurrently and incrementally validates the informal MAS requirement models produced. The synthesis of the process is first justified and illustrated in a manual tracing of the process. The paper then describes an interactive support tool to harness the formal semantics of ontologies and by pass the costly manual effort. The validation process is evaluated and illustrated using three case studies.

Published
2016

32. 249 CONNECT MDS AND AML: THE MYELODYSPLASTIC SYNDROMES (MDS) AND ACUTE MYELOID LEUKEMIA (AML) DISEASE REGISTRY

Author

Steensma, D., primary, Abedi, M., additional, Bejar, R., additional, Cogle, C., additional, Foucar, K., additional, Garcia-Manero, G., additional, George, T., additional, Grinblatt, D., additional, Komrokji, R., additional, Maciejewski, J., additional, Pollyea, D., additional, Roboz, G., additional, Savona, M., additional, Scott, B., additional, Sekeres, M., additional, Thompson, M., additional, Sugrue, M., additional, Swern, A., additional, Nifenecker, M., additional, and Erba, H., additional

Published
2015
Full Text
View/download PDF

34. A methodology for ontological knowledge capture from databases

Author

García-Sánchez, F., Fernández-Breis, J.T., and Martínez-Bejar, R.

Subjects
Моделі і засоби систем баз даних і знань
Abstract

The successful emergence of the Information and Communication Technologies (ICT) has contributed to the efficiency improvement in a number of economic sectors. However, some strategic economic sectors, such as construction, have not been targeted enough yet. Construction-related ICT solutions lack mechanisms to permit the effective integration of the whole supply chain. Semantic Web can tackle these issues. This paper presents a methodology for acquiring knowledge from construction-related databases. A domain ontology has been developed that contains the relevant concepts regarding supply management in the construction domain. The methodology basically consists of mapping the database content onto the ontology and a further this one’s population by applying a set of mapping rules. Успешное появление информационно-коммуникационных технологий (ИКТ) внесло свой вклад в повышение эффективности многих секторов экономики. Однако, некоторые стратегические экономические сектора, такие, как строительство, не были все же достаточно исследованы. Связанные со строительством решения ИКТ испытывают недостаток в механизмах, позволяющих разрешать проблемы эффективной интеграции полной цепочки поставки. Семантическая Сеть может заняться этими проблемами. Эта статья представляет методологию, позволяющую извлекать знание из баз данных, связанных со строительством . Была разработана онтология домена, содержащая релевантные понятия, касающиеся управления поставками в домене строительства. Методология в основном состоит из отображения содержания базы данных на онтологию и дальнейшего ее заполнения , применяя набор правил отображения .

Published
2008

38. O-024 Next-generation sequencing of 213 MDS patient samples identifies mutation profiles associated with response to hypomethylating agents and overall survival

Author

Bejar, R., primary, Stevenson, K., additional, Stojanov, P., additional, Zaneveld, J.E., additional, Bar-Natan, M., additional, Caughey, B., additional, Wang, H., additional, Garcia-Manero, G., additional, Kantarjian, H., additional, Cibulskis, K., additional, Getz, G., additional, Steensma, D.P., additional, Stone, R.M., additional, Chen, R., additional, Neuberg, D., additional, and Ebert, B.L., additional

Published
2013
Full Text
View/download PDF

39. P-103 Occult NRAS mutations with very low allele burden have independent prognostic significance in lower-risk myelodysplastic syndromes

Author

Bejar, R., primary, Murphy, D.M., additional, Stevenson, K., additional, Neuberg, D., additional, Shi, Y., additional, Cubrich, C., additional, Richardson, K., additional, Eastlake, P., additional, Garcia-Manero, G., additional, Kantarjian, H., additional, Ebert, B.L., additional, and Makrigiorgos, G.M., additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results