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2. Association between antimicrobial usage in livestock and antimicrobial resistance in Escherichia coli isolates from human urinary tract infections in the Netherlands, 2009–2020.

Author

Meijs, Anouk P, Chanamé-Pinedo, Linda E, Deng, Huifang, Veldman, Kees T, Brouwer, Michael S M, Beld, Maaike J C van den, Dierikx, Cindy M, Sanders, Pim, Wullings, Bart, Greeff, Sabine C de, Duijkeren, Engeline van, Franz, Eelco, Pijnacker, Roan, Mughini-Gras, Lapo, and group, ISIS-AR study

Subjects
ESCHERICHIA coli, URINARY tract infections, DOMESTIC animals, ANIMAL populations, DRUG resistance in microorganisms
Abstract

Background In the last decade, veterinary antimicrobial usage (AMU) and antimicrobial resistance (AMR) among indicator bacteria in livestock have decreased substantially in the Netherlands. The extent to which this decrease has affected AMR levels among human infections remains unclear. Objectives To assess the association between AMU in livestock and AMR in Escherichia coli isolates from human urinary tract infections (UTIs). Methods Data on AMR and AMU between 2009 and 2020 from Dutch national surveillance programmes for humans and livestock were used. Associations between AMU in four major livestock sectors and AMR in humans were assessed for 10 antimicrobial classes and the ESBL resistance profile, using logistic regression analysis. Associations between AMU and AMR in livestock, between AMR in livestock and in humans, and between AMU and AMR in humans were also assessed. Results Statistical significance was reached for 16/31 of the tested associations between AMU in livestock and AMR in human E. coli UTIs. Of the significant associations, 11 were positive (OR 1.01–1.24), whereas 5 were negative (OR 0.96–0.99). All associations between human AMU and AMR in E. coli isolates from UTIs were positive and statistically significant. Weak but significant positive correlations were also observed between livestock AMR and human AMR. Conclusions Although several significant associations between AMU in livestock and AMR in human UTIs caused by E. coli were observed, the associations between AMU and AMR were generally stronger within the human and animal populations. This indicates that potential zoonotic spread of AMR in E. coli causing human UTIs from livestock sources is limited. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Large outbreak of typhoid fever on a river cruise ship used as accommodation for asylum seekers, the Netherlands, 2022.

Author

Ooms, Daisy, de Vries, Anne, Koedijk, Femke D. H., Generaal, Ellen, Friesema, Ingrid H. M., Rouvroye, Maxine, van Lelyveld, Steven F. L., van den Beld, Maaike J. C., Notermans, Daan W., van Schelven, Patrick, van den Brink, Janine F. H., Hartog, Tanja, Veenstra, Thijs, Slavenburg, Serena, Sinnige, Jan C., and Ruijs, Wilhelmina L. M.

Published
2024
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5. Sporadic Occurrence of Enteroaggregative Shiga Toxin-Producing Escherichia coli O104:H4 Similar to 2011 Outbreak Strain

Author

Coipan, Claudia E, Friesema, Ingrid H, van den Beld, Maaike J C, Bosch, Thijs, Schlager, Sabine, van der Voort, Menno, Frank, Christina, Lang, Christina, Fruth, Angelika, and Franz, Eelco

Subjects
STEC, food safety, Shiga toxin-producing Escherichia coli, Austria, enteric infections, public health, the Netherlands, foodborne infections, bacteria, enteroaggregative E. coli, O104:H4, zoonoses
Published
2023

8. Sporadic Occurrence of Enteroaggregative Shiga Toxin-Producing Escherichia coli O104:H4 Similar to 2011 Outbreak Strain.

Author

Coipan, Claudia E., Friesema, Ingrid H., van den Beld, Maaike J. C., Bosch, Thijs, Schlager, Sabine, van der Voort, Menno, Frank, Christina, Lang, Christina, Fruth, Angelika, and Franz, Eelco

Abstract

We describe the recent detection of 3 Shiga toxin-producing enteroaggregative Escherichia coli O104:H4 isolates from patients and 1 from pork in the Netherlands that were genetically highly similar to isolates from the 2011 large-scale outbreak in Europe. Our findings stress the importance of safeguarding food supply production chains to prevent future outbreaks. [ABSTRACT FROM AUTHOR]

Published
2022
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9. A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters

Author

van den Beld, Maaike J. C., primary, Reubsaet, Frans A. G., additional, Pijnacker, Roan, additional, Harpal, Airien, additional, Kuiling, Sjoerd, additional, Heerkens, Evy M., additional, Hoeve-Bakker, B. J. A. (Dieneke), additional, Noomen, Ramón C. E. A., additional, Hendriks, Amber C. A., additional, Borst, Dyogo, additional, van der Heide, Han, additional, Kooistra-Smid, A. M. D. (Mirjam), additional, and Rossen, John W. A., additional

Published
2020
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11. Genome-wide association studies of Shigella spp. and Enteroinvasive Escherichia coli isolates demonstrate an absence of genetic markers for prediction of disease severity.

Author

Hendriks, Amber C. A., Reubsaet, Frans A. G., Kooistra-Smid, A. M. D. (Mirjam), Rossen, John W. A., Dutilh, Bas E., Zomer, Aldert L., van den Beld, Maaike J. C., On behalf of the IBESS group, van den Beld, M. J. C., Warmelink, E., Kooistra-Smid, A. M. D., Friedrich, A. W., Reubsaet, F. A. G., Notermans, D. W., Petrignani, M. W. F., Waegemaekers, C. H. F. M., Rossen, J. W. A., van Dam, A. P., Svraka-Latifovic, S., and Verweij, J. J.

Subjects
SHIGELLOSIS, GENETIC markers, ESCHERICHIA coli, SHIGELLA, ALGORITHMS, SYMPTOMS
Abstract

Background: We investigated the association of symptoms and disease severity of shigellosis patients with genetic determinants of infecting Shigella and entero-invasive Escherichia coli (EIEC), because determinants that predict disease outcome per individual patient could be used to prioritize control measures. For this purpose, genome wide association studies (GWAS) were performed using presence or absence of single genes, combinations of genes, and k-mers. All genetic variants were derived from draft genome sequences of isolates from a multicenter cross-sectional study conducted in the Netherlands during 2016 and 2017. Clinical data of patients consisting of binary/dichotomous representation of symptoms and their calculated severity scores were also available from this study. To verify the suitability of the methods used, the genetic differences between the genera Shigella and Escherichia were used as control. Results: The isolates obtained were representative of the population structure encountered in other Western European countries. No association was found between single genes or combinations of genes and separate symptoms or disease severity scores. Our benchmark characteristic, genus, resulted in eight associated genes and > 3,000,000 k-mers, indicating adequate performance of the algorithms used. Conclusions: To conclude, using several microbial GWAS methods, genetic variants in Shigella spp. and EIEC that can predict specific symptoms or a more severe course of disease were not identified, suggesting that disease severity of shigellosis is dependent on other factors than the genetic variation of the infecting bacteria. Specific genes or gene fragments of isolates from patients are unsuitable to predict outcomes and cannot be used for development, prioritization and optimization of guidelines for control measures of shigellosis or infections with EIEC. [ABSTRACT FROM AUTHOR]

Published
2020
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12. Evaluation of a culture dependent algorithm and a molecular algorithm for identification of Shigella spp., Escherichia coli, and enteroinvasive E. coli (EIEC)

Author

van den Beld, Maaike J C, de Boer, Richard F, Reubsaet, Frans A G, Rossen, John W A, Zhou, Kai, Kuiling, Sjoerd, Friedrich, Alexander W, and Kooistra-Smid, Mirjam A M D

Abstract

Identification of Shigella spp., Escherichia coli and enteroinvasive E. coli is challenging, because of their close relatedness. Distinction is vital, as infections with Shigella spp. are under surveillance of health authorities, in contrast to EIEC infections. In this study, a culture dependent identification algorithm and a molecular identification algorithm were evaluated. Discrepancies between the two algorithms and original identification were assessed using Whole Genome Sequencing (WGS). After discrepancy analysis, with the molecular algorithm, 100% of the evaluated isolates were identified in concordance with original identification. However, the resolution for certain serotypes was lower than previously described methods and lower than the culture dependent algorithm. Although, the resolution of the culture dependent algorithm is high, 100% of non-invasive E. coli, S. sonnei, S. dysenteriae, 93% of S. boydii and EIEC and 85% of S. flexneri were identified in concordance with the original identification. Discrepancy analysis using WGS was able to confirm one of the used algorithms in four discrepant results. However, it failed to clarify three other discrepant results as it added yet another identification. Both proposed algorithms performed well for the identification of Shigella spp and EIEC, and are applicable in low-resource settings in contrast to earlier described methods that require WGS for daily diagnostics. Evaluation of the algorithms showed that both algorithms are capable of identifying Shigella species and EIEC isolates. The molecular algorithm is more applicable in clinical diagnostics for fast and accurate screening, while the culture dependent algorithm is more suitable for reference laboratories to identify Shigella spp. and EIEC up to serotype level.

Published
2018

14. The importance of a multifactorial approach for (inter)national surveillance of Shigella spp. and entero-invasive Escherichia coli

Author

Beld, Maaike J. C. van den, primary, Reubsaet, Frans A.G., additional, Pijnacker, Roan, additional, Harpal, Airien, additional, Kuiling, Sjoerd, additional, Heerkens, Evy M., additional, Hoeve-Bakker, B. J. A. (Dieneke), additional, Noomen, Ramón C.E.A., additional, Hendriks, Amber C. A, additional, Borst, Dyogo, additional, Heide, Han van der, additional, Kooistra, A.M.D. (Mirjam), additional, and Rossen, John W.A., additional

Published
2019
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19. Abstracts of papers

Author

Rodrigues de Miranda, J. F., van der Weide, J., Tepper, P. C., de Vries, J. B., Horn, A. S., Ijzerman, A. P., Bultsma, T., Timmerman, H., Tulp, M. Th. M., Janssen, L. H. M., de Kaste, D., van Buuren, K. J. H., Soudijn, W., Kloosterboer, H. J., Bergink, E. W., van Oene, Joop C., Kebabian, John W., Rademnker, B., Bast, A., Kramer, K., Rademaker, B., Bakri, A., BeijersberRen van Henegouwen, G. M. J., de Vries, H., Wilting, J., Underberg, W. J. M., Busker, R. W., Beijersbergen van Henesouwen, G. M. J., Beijersbergen van Henegouwen, G. M. J., de Zwart, M., van der Goot, H., Donne-Op den Kelder, G. M., Bijloo, G. J., Haaksma, E. E. J., Eriks, J. Ch., Severne, Y., Nerme, V., Vauquelin, G., Leurs, R., Mennen, M. M., Plantjé, J. F., Stoof, J. C., 't Hart, B. J., de Gier, J. J., Straat, R. v. d., Kulkons, T., Debets, A. J. J., de Vries, J., Verneulen, H. P. E., van der Werf, J. F., van der Kuyl, A. C., van Maanen, J. M. S., de Ruiter, C., Kootstra, P. R., Broersen, J., Lafleur, M. V. M., Retèl, J., Pinedo, H. M., Wezel, K., Bakker, E. I., Wolf, M., Beld, A. J., and Mutschler, E.

Published
1985
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21. Abstracts of papers

Author

Slangen, J. L., Ciurgea, C. E., Jolles, J., van Amsterdam, J. G. C., van Buuren, K. J. H., Soudijn, W., van Oene, J. C., de Vries, J. B., Dijkstra, D., Renkema, R. J. W., Tepper, P. G., Horn, A. S., Bast, A., Savenije-Chapel, E. M., Kroes, B. H., Nugteren, H. A., de Haan, F. H. N., Joosten, J. G. H., Jansen, A. C. A., Koopmans, R. E., Rekker, R. F., Ijzerman, A. P., Aué, G., Bultsma, T., Timmerman, H., Krielaart, M. J., von der Schaar, M. W. G., Rademaker, B., Zaagsma, J., van Koppen, C. J., Siero, H. L. M., Rodrigues de Miranda, J. F., Beld, A. J., Ariëns, E. J., Scheres, H. M. E., Klaassen, A. B. M., Kuypers, W., van Amsterdam, F. T. M., Sterk, G. J., van der Goot, H., van Maanen, J. M. S., Cobas, F., de Ruiter, C., de Vries, J., Pinedo, H. M., Linschoten, M. R., Gaisser, H. -D., Dröge, J. H. M., Janssen, L. H. M., Wilting, J., Voorbrood, E. L. M., Kremer, J. M. H., Bakri, A., Beijersbergen van Henegouwen, G. M. J., de Vries, H., Huf, F. A., Sedee, A. G. J., Lusthof, K. J., Lodder, G., de Mol, N. J., Busker, R. W., Drexler, T. B., Weeda, L., Maanders, J. P. A. C. M., Posthuma, R. M., Mohn, G. R., Plantlé, J. F., Daus, F. J., Hansen, H. A., Stoof, J. C., Hazelhoff, B., Dijkstra, P., Mulder, T., Elferink, F., van der Vijgh, W. J. F., Brussee, J., te Koppele, J. M., and Groenendijk, J. L. G.

Published
1984
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22. Abstracts of papers pharmacological meeting

Author

Beckorinqh, J. J., Korstanje, C., van Zwieten, P. A., Boddeke, H. W. G. M., Jonkman, F. A. M., Daemen, M., van Essen, H., Smits, J., Thljssen, H., de Bruijn, E. A., Driessen, O., Hermans, J., de Graeff, P. A., Kingma, J. H., van Gilst, W. H., Bel, K., de Langen, C. D. J., Wesselinq, H., Doods, H. N., Davidesko, D., Mathy, M. -J., Batink, H. D., de Jonge, A., Ellenbroek, B., Klockgether, T., Turskit, L., Schwarz, M., Cools, A., Franken, N. A. P., van Delft, J. L., van Langevelde, A., Dubbelman, T. M. A. R., Oosterhuis, J. A., Star, W. M., Marljnissen, J. P. A., Journée-de Korver, J. G., Pauwels, E. K. J., Haenen, G. R. M. M., Bast, A., de Vries, J., Vcrmeulen, N. P. E., Timmerman, H., Hugtenburg, J. G., Beckeringh, J. J., Janssen, B. J. A., Struyker-Boudier, H. A. J., Smits, J. F. N., Jonkman, P. A. M., Man, P. W., Knape, J. T. A., Lambalk, C. B., van Kessel, H., van Rees, G. P., Schoemaker, J., Lammers, J. H. C. M., Meelis, W., Kruk, M. R., van der Poel, A. M., Lippens, F. J. P., van Valkenburg, C. F. M., van der Krogt, J. A., Krick, E. W. C., Belfroid, R. D. M., Noach, E. L., Loesberg, C., Woutersen-v. Nijnanten, F. M. A., Nijkamp, F. P., Molenaar, P. C., Pen, B. S., Polak, R. L., Nievelstein, H. N. M. W., Tijssen, C. M., Smits, J. F. M., Plant jé, J. F., Stoof, J. C., Maikel Kaghoebar, Jan A., Huisman, M., van Ginneken, Cees A. M., Rahusen, F. D., Robillard, G. T., Wildevuur, Ch. R. N., Russel, F. C. M., van der Linden, P. E. M., Vermeulen, W. G., van Ginneken, C. A. M., Smits, R. P. J. H., Steinhusch, H. U. M., Mulder, A. H., ten Brink, E. M. J., van der Plas, J., van Giersbergen, P. L. M., Wlegant, V. M., de Jong, W., van Koppen, C. J., Hermanussen, M. W., Verrijp, C. N., Rodrigues de Miranda, J. F., Beld, A. J., Lammers, J. W. J., van Oosterhout, A. J. M., Vulto, Arnold G., Sharp, Trevor, Ungerstedt, Urban, Wolterink, G., and van Ree, J. M.

Published
1985
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23. Abstracts of papers

Author

Biessels, P. T. M., Agoston, S., Horn, A. S., van Amsterdam, J. G. C., van Buuren, K. J. H., Soudijn, W., Brussee, J., Jansen, A. C. A., Kühn, A., Buhl, T., Rodrigues de Miranda, J. F., Beld, A. J., Lambrecht, G., Mutschler, E., Bultsma, T., Linschoten, M. R., Timmerman, H., Dröge, J. H. M., Wachter, A. A. H., Gaisser, H. D., van der Goot, H., Timnerman, H., Haenen, G. R. M. M., Bast, A., Grünbauer, H. J. M., Hall, David W. R., de Wijn, Spencer R., de Jong, J., de Vries, J., de Klerk, S. J., de Haan, F. H. N., Kelder, J., de Boer, Th., de Graaf, J. S., Wieringa, J. H., Krielaart, M. J., Veenstra, D. M. J., Zuiderveld, O. P., de Mol, N. J., Nieuwenhuyse, Hugo, Koenen, J., Mohn, G. R., Salden, H. J. M., Schonewille, E., Kothuis, M. J. M., Sterk, G. J., van der Schaar, M. W. G., Rademaker, B., van de Straat, R., de Boer, H., Vromans, R. M., Tijms, R. P. J. H., Bosman, P., and Zaagsma, J.

Published
1984
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24. Abstracts of papers

Author

Kleinbloesem, C. H., van Brummelen, P., van de Linde, J. A., Breimer, D. D., Kerremans, A. L. M., Cremers, H. J., Rodrigues de Miranda, J. F., van Ginneken, C. A. M., Gribnau, F. W. J., Schols, M., Mooy, J., van Hooff, M., van Baak, M. A., Rahn, K. H., Soeterboek, A. M., van Thiel, M., Westra, P., Vermeer, G. A., van Rooy, H. H., Pirovano, I. M., Soudijn, W., Lohman, J. J. H. M., Hooymans, P. M., Verhey, M. T. J. M., Pluym, B. F. M., Merkus, F. W. H. M., Thijssen, H. H. W., Baars, L. G., Reijnders, M. J., Wagenvoort, J. H. T., Fieren, M. W. J. A., Goessens, W. H. F., Michel, M. F., Edelbroek, P. M., Zitman, F. G., Schreuder, J. N., Rooymans, H. G. M., de Wolff, F. A., Hekster, Ch. A., Vree, T. B., van Baak, M. A., Jennen, W. H. J., Verstappen, F. T. J., Salemans, J., Lenders, J. W. M., Fennis, J., Thien, Th., Houben, H., Binkhorst, R. A., van 't Laar, A., Koopmans, P. P., van Hees, P. A. M., Hoefnagels, W. H. L., Huysmans, F. T. M., Woittiez, A. J. J., Wenting, G. J., Derkx, F. H. M., Schalekamp, M. A. D. H., Storms, G. E. M. G., Lutterman, J. A., de Nobel, E., van 't Laar, A., Sitsen, J. M. A., de Jong, W., Stuyt, P. M. J., Stalenhoef, A. F. H., Demacker, P. N. M., van 't Laar, A., Oosterhuis, B., Berge, R. J. M.ten, Sauerwein, N. P., Endert, E., Schellekens, P. Th. A., van Boxtel, C. J., Terpstra G. K., Raaijmakers, J. A. M., Wassink, G. A., Kreukniet, J., Bakker, J. C., de Vries-v. Rossen, A., Bleeker, W. K., Ufkes, J. G. R., van Rosevelt, R. F., van Mourik, J. A., Loos, J. A., Brummelhuis, H. G. J., Schalken, J. J., Lammers, J. W. J., Beld, A. J., and van Herwaarden, C. L. A.

Published
1983
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25. Dutch Pharmacological Meeting 1984

Author

Timmerman, H., Koeman, J. H., den Tonkelaar, E. H., Merkus, F. W. H. M., Struyker-Boudier, H. A. J., Bolt, G. R., Saxena, P. R., Bos, R. P., Breed, A. S. P. M., Theuws, J. L. G., Henderson, P. Th., de Brauw, L. M., de Bruijn, E. A., van de Velde, C. J. H., Tjaden, U. R., Kothuis, B. J. L., van Oosterom, A. T., Reeuwijk, H. J. E. M., Pinedo, H. M., van der Hoeven, R., Bultsma, T., Linschoten, M. R., Peter, J., Burbach, H., de Kloet, E. Ronald, Castelein, O., Verbeke, N., Leuven, K. U., Conings, L., Doods, H. N., Kalkman, H. O., de Jonge, A., Wilffert, B., Thoolen, M. J. M. C., Timmermans, P. B. M. W. M., van Zwieten, P. A., van Driel, J. B. M., Klaassen, A. B. M., Kuypers, W., Beld, A. J., Rodrigues de Miranda, J. F., Driessen, O., van der Velde, E. A., Engels, F., Oosting, R. S., Nijkamp, F. P., Evelo, C. T. A., Neis, J. M., Peters, J. G. P., ten Broeke, M. A. M., Vulders, C. A. J. M., Franssen, M. J. A. M., van Herwaarden, C. L. A., van de Putte, L. B. A., Gribnau, F. W. J., van der Graaff, M., Vermeulen, N. P. E., Hofman, P. H., Breimer, D. D., 't Hart, B. J., Wilting, J., de Gier, J. J., Hazelhoff, Bernard, de Vries, Jan B., Oijkstra, Durk, Mulder, Theo, Wynberg, Hans, Horn, Alan, van Doorn, R., Leijdekkers, Ch. -M., Anzion, R., Hengstum, M. v., Festen, J., Buijs, W., Broek, W. v. d., Groothedde, R., Corstens, F., van Heuven-Nolsen, P., de Wildt, D. J., Hillen, F. C., van Noordwijk, J., Janssen, Lambert H. M., Jansen, P. A. F., Meyboom, R. H. B., Vree, T. B., Jelinek, J., Schönbaum, E., Lomax, P., de Jong, W., Sandor, P., Cox van Put, J. J., Jongeneelen, F. J., Leijdekkers, Ch. M., Kerklaan, P. R. M., Zoetemelk, C. E. M., Mohn, G. R., Grote, J. J., Kuijpers, W., Kleinbloesem, C. H., van Brummelen, P., van Harten, J., Koopmans, P. P., Kateman, W., Tan, Y., van Ginneken, C. A. M., van Koppen, C. J., van der Beek, E. M., Lammers, J. W. J., Krielaart, M. J., Laban, E., Charbon, G. A., Folgering, H. Th. M., Lenders, J. W. M., Sluiter, H. E., Willemsen, J., Thien, Th., Mooy, J., Schols, M., Baak, M. v., Hooff, M. v., Rahn, K. H., Mulder, Theo B. A., Grol, Cor J., Dijkstra, Durk, Horn, Alan S., Neef, C., Meijer, D. K. F., van Gemert, P. J. L., Roelofs, H. M. J., Osterhuis, B. O, ten Berge, R. J. M., Schellekens, P. T. A., van Boxtel, C. J., Peeters, P. A. M., Raghoebar, M., Tiemessen, H. L. G. H., Raaijmakers, J. A. M., van Rozen, A. J., Terpstra, G. K., Wassink, G. A., Kreukniet, J., Remeyer, L. R., Reeuwijk, H. J. E., Touw, D. J., Rollema, Hans, Mastebroex, Dora, Russel, F. G. M., Wouterse, A. C., Rijk, M. C. M., Salden, H. J. M., De Schaepdryver, A. F., Lefebvre, R. A., Bogaert, M. G., Scheres, H. M. E., Salden, H. J. H., Siero, H. L. M., Slee, P. H. Th. J., van den Berg, L., Huysmans, F. Th. M., Koene, R. A. P., Smits, J. F. M., Nievelstein, H. M. N., Struyker Boudier, H. A. J., Raaijmakers, J. A. H., Huidekoper, H. J., Thljssen, H. H. W., Baars, L. C. M., Mathy, M. J., Veldhoven, C. M. M., AriËns, E. J., Ruland, C. M., de Vos, Cor, de Graaf, Joop, van Aalst, Gerard, Steenbergen, Hans, Hekster, Y. A., Tijhuis, M. W., Nouws, J. F. M., Wollersheim, H., Fennis, J., van 't Laar, A., Wijnands, W. J., van der Gen, A., Jzerman, A. P. I., Aué, G., Dorlas, R., Krajnc, E. I., Loeber, J. G., van Leeuwen, F. X. R., Wester, P. W., Vos, J. G., Vaessen, H. A. M. G., Heijden, C. A. v. d., Canton, J. H., de Klerk, A., Krajc, E. I., Kruizinga, W., van Ommen, B., Rozing, J., van der Heijden, C. A., van der Voet, G. B., de Wolff, F. A., Edelbroek, Peter M., de Reus, Margot J. H., van den Berg, Tjeerd, and de Wolff, Frederik A.

Published
1984
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26. Abstracts of papers

Author

Rollema, H., Grol, C. J., Feenstra, M. G. P., van Oene, Joop C., Houwing, Hendrik A., Horn, Alan S., Ijzerman, A. P., Bultsma, T., Timmerman, H., Zaagsma, J., van der Graaff, M., Vermeulen, N. P. E., Joeres, R. P., Breimer, D. D., Tsantili-Kakoulidou, A., van der Valk, F., Rekker, R. F., Bijloo, G. J., Zoetemelk, C. E. M., van Hoven, W., van Meeteren-Wālchli, B., van der Gen, A., Mohn, G. R., Buijs, W., Breimer, D. D., Onkenhout, W., de Jong, H. J., Rog, A. A., van Ginneken, C. A. M., Lentjes, E. G. W. M., Bast, A., Savenije-Chapel, E. M., Noordhoek, J., Beld A. J., Rodrigues de Miranda J. F., van Ginneken C. A. M., van der Giesen, W. F., Dröge, J. H. M., Wilting, J., Janssen, L. H. M., van Amsterdam J. G. C., van Buuren, K. J. H., Wijnne, H. J. A., Nolet, M. R. A., Kremer, J. M. H., Bakker, G., van der Heijden, P. J. C. M., van der Schaar, M. W. G., Bank, C. M. C., Eriks, J. Ch., Gaisser, H. -D., van der Goot, H., Sterk, G. J., Zaagsma, J., Lock, F. M., de Vries, J., Mullink, H., van Bree, L., Redegeld, F. A. M., Grolleman, C. W. J., de Visser, A. C., Wolke, J. G. C., Buchan, P., and Burns, J. W.

Published
1982
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27. Jobcoaching met moeilijke mensen

Author

Schaap, C.P.D.R., Keijsers, G.P J, Hell, J G F, Hoogduin, W A, van den Beld, P J, Hell, J.G.F., Hoogduin, W.A., Beld, P.J. van den, and Experimental Psychotherapy & Psychopathology

Subjects
Experimental Psychopathology and Treatment, Arbeidsgeneeskunde
Abstract

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Published
1999

29. Lighting for work: a review of visual and biological effects.

Author

Van Bommel, W. J. M. and Van Den Beld, G. J.

Subjects
*LIGHTING, *ENVIRONMENTAL engineering of buildings, *RETINA, *EYE, *BIOLOGY
Abstract

With the detection in 2002 of a novel photoreceptor cell in the eye, the biological effects that light has can be better understood. From the research on the biological effects of lighting, it is evident that the rules governing the design of good and healthy lighting installations are, to a certain degree, different from the conventionally held rules. We demonstrate that it can be beneficial to be able to adapt both the level and the colour of the lighting. Not only the light on the visual task, but also that entering the eye determines the overall quality of lighting. In a working environment, not only are the advantages in terms of health and wellbeing important for the workers themselves, they also lead to better work performance, fewer errors, better safety, and lower absenteeism. [ABSTRACT FROM AUTHOR]

Published
2004
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30. Beta adrenoceptor binding and induced relaxation in airway smooth muscle from patients with chronic airflow obstruction.

Author

van Koppen, C J, de Miranda, J F, Beld, A J, van Herwaarden, C L, Lammers, J W, and van Ginneken, C A

Abstract

Beta adrenoceptor function in central airway smooth muscle of patients with chronic airflow obstruction was investigated by radioligand binding studies and isoprenaline relaxation experiments. Receptor characteristics were determined in tracheal smooth muscle preparations obtained at necropsy from 12 patients and in bronchial tissue obtained at thoracototomy from 21 patients with chronic airflow obstruction. Receptor characteristics were compared with those obtained in airway tissue preparations from 65 control subjects without chronic airflow obstruction. The number of beta adrenoceptors, their binding affinity for the radioligand [125I]-(-)-cyanopindolol, and the tissue binding characteristics of isoprenaline were similar in tissue from patients with chronic airflow obstruction and from control subjects. Isoprenaline induced relaxation of tracheal smooth muscle without precontraction by methacholine showed slightly (though not significantly) less sensitivity to isoprenaline in patients with chronic airflow obstruction than in control subjects (mean (SEM) pD2--the negative logarithm of the concentration producing 50% relaxation--6.32 (0.16) v 6.62 (0.15)). The same pattern of pD2 values was found in segmental bronchial strips without precontraction by methacholine (chronic airflow obstruction 6.55 (0.27), control 7.14 (0.12)). Isoprenaline relaxation in segmental bronchial strips when contracted maximally was significantly less in the patients with airflow obstruction than in the control subjects (pD2 value 5.99 (0.18) v 6.45 (0.07)). These results suggest that beta adrenoceptors in airway smooth muscle of patients with chronic airflow obstruction are not abnormal in number or in binding affinity but that there is less effective coupling between components of the relaxant system distal to the beta adrenoceptor. The possibility that the reduced isoprenaline sensitivity is a consequence of previous bronchodilator treatment cannot be excluded. [ABSTRACT FROM PUBLISHER]

Published
1989

31. Increasing the Efficiency of a National Laboratory Response to COVID-19: a Nationwide Multicenter Evaluation of 47 Commercial SARS-CoV-2 Immunoassays by 41 Laboratories

Author

van den Beld, Maaike J. C., Murk, Jean-Luc, Kluytmans, Jan, Koopmans, Marion P. G., Reimerink, Johan, van Loo, Inge H. M., Wegdam-Blans, Marjolijn C. A., Zaaijer, Hans, GeurtsvanKessel, Corine, and Reusken, Chantal

Abstract

In response to the worldwide pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the subsequent antibody tests that flooded the market, a nationwide collaborative approach in the Netherlands was employed. Forty-one Dutch laboratories joined forces and shared their evaluation data to allow for the evaluation of a quantity of serological assays for SARS-CoV-2 that exceeds the capacity of each individual laboratory.

Published
2021
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32. Autoradiographic visualization of muscarinic receptors in human bronchi.

Author

van Koppen, C J, Blankesteijn, W M, Klaassen, A B, Rodrigues de Miranda, J F, Beld, A J, and van Ginneken, C A

Abstract

To visualize muscarinic receptors in human bronchi, the stripping film method was used which permits direct autoradiographic localization of tissue labeling. Cryostate sections of human bronchi were fixed in 0.5% glutaraldehyde in Krebs-Ringer buffer, pH 7.0 for 30 min at 0 degrees C, washed in Krebs-Ringer buffer for 20 min at 0 degrees C and incubated with (-)-[3H]Quinuclidinyl benzilate [(-)-[3H]QNB] for 90 min at 37 degrees C. Specific (-)-[3H]QNB binding to tissue sections was saturable (receptor density of 0.14 +/- 0.03 fmol/tissue section) and of high affinity (Kd of 40 +/- 9 pM). For autoradiography, labeled tissue sections were covered with stripping film and exposed for 5 months. Muscarinic receptors in human bronchi were located predominantly in submucosal glands and parasympathetic ganglia. There was less labeling in smooth muscle cells and nerve bundles. Epithelium and blood vessels located within the bronchial wall were devoid of specific labeling.

Published
1988

33. Cholinergic Receptors in the Upper Respiratory System of the Rat

Author

Klaassen, André B. M., Kuijpers, Wim, Scheres, Huub M. E., de Miranda, Jaap F. Rodrigues, and Beld, Arie J.

Abstract

• Radioligand receptor binding might give more detailed information on the innervation pattern of the nasal mucosa and the character of the various neuroreceptors involved. With respect to the cholinergic receptors, this technique reveals that specific binding of tritiated l-quinuclidinyl benzilate to rat nasal mucosa homogenates occurs to a homogeneous class of binding sites, with a dissociation constant of 0.06 ± 0.02nM and a receptor density of 8 ± 2 pmole/g of tissue. Binding is stereoselectively inhibited by benzetimide hydrochloride enantiomers. Pirenzepine displacement (inhibition constant = 0.5 × 10−6M) classifies tritiated l-quinuclidinyl benzilate binding sites as M2-muscarinic receptors. Methylfurthrethonium inhibits tritiated l-quinuclidinyl benzilate binding at high concentrations, pointing to the presence of low-affinity agonist binding sites, probably admixed with a small proportion of high-affinity agonist binding sites. These data obtained in the rat open new perspectives for studying muscarinic receptors in the human nose to elucidate the supposed disturbance of autonomic nerve regulation in nasal hyperreactivity.(Arch Otolaryngol Head Neck Surg 1986;112:428-431)

Published
1986
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35. Characterization of the muscarinic receptor in human tracheal smooth muscle

Author

Koppen, Chris J., Rodrigues de Miranda, Jaap F., Beld, Arie J., Hermanussen, Marcel W., Lammers, Jan Willem J., and Ginneken, Cees A. M.

Abstract

Muscarinic receptors in human tracheal smooth muscle were characterized by radioligand binding and functional studies. Specific [3H]-(-)-quinuclidinylbenzilate ([3H]-(-)-QNB) binding to tracheal smooth muscle membranes was reversible, stereoselective and of high affinity (Kd=47±4 pmol/l;RT=920±120 fmol/g tissue). Inhibition of specific [3H]-(-)-QNB binding by the M-1 selective antagonist pirenzepine was found to occur at relative high concentrations classifying the muscarinic receptor population as belonging to the M-2 subclass.

Published
1985
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36. Incidence, clinical implications and impact on public health of infections with Shigella spp. and entero-invasive Escherichia coli (EIEC): results of a multicenter cross-sectional study in the Netherlands during 2016-2017.

Author

van den Beld, Maaike J. C., Warmelink, Esther, Friedrich, Alexander W., Reubsaet, Frans A. G., Schipper, Maarten, de Boer, Richard F., Notermans, Daan W., Petrignani, Mariska W. F., van Zanten, Evert, Rossen, John W. A., Friesema, Ingrid H. M., Kooistra-Smid, A. M. D. (Mirjam), on behalf of the IBESS working group, van Dam, A. P., Svraka-Latifovic, S., Kooistra-Smid, A. M. D., Verweij, J. J., Bruijnesteijn van Coppenraet, L. E. S., Waar, K., and Hermans, M.

Subjects
*SHIGELLOSIS, *ESCHERICHIA coli, *PUBLIC health, *FOOD contamination, *CROSS-sectional method, *SHIGELLA
Abstract

Background: Shigella spp. and entero-invasive E. coli (EIEC) use the same invasive mechanism to cause diarrheal diseases. Public health regulations apply only to Shigella spp. infections, but are hampered by the lack of simple methods to distinguish them from EIEC. In the last decades, molecular methods for detecting Shigella spp. and EIEC were implemented in medical microbiological laboratories (MMLs). However, shigellosis cases identified with molecular techniques alone are not notifiable in most countries. Our study investigates the impact of EIEC versus Shigella spp. infections and molecular diagnosed shigellosis versus culture confirmed shigellosis for re-examination of the rationale for the current public health regulations.Methods: In this multicenter cross-sectional study, fecal samples of patients suspected for gastro-enteritis, referred to 15 MMLs in the Netherlands, were screened by PCR for Shigella spp. or EIEC. Samples were cultured to discriminate between the two pathogens. We compared risk factors, symptoms, severity of disease, secondary infections and socio-economic consequences for (i) culture-confirmed Shigella spp. versus culture-confirmed EIEC cases (ii) culture positive versus PCR positive only shigellosis cases.Results: In 2016-2017, 777 PCR positive fecal samples with patient data were included, 254 of these were culture-confirmed shigellosis cases and 32 were culture-confirmed EIEC cases. EIEC cases were more likely to report ingestion of contaminated food and were less likely to be men who have sex with men (MSM). Both pathogens were shown to cause serious disease although differences in specific symptoms were observed. Culture-negative but PCR positive cases were more likely report travel or ingestion of contaminated food and were less likely to be MSM than culture-positive cases. Culture-negative cases were more likely to suffer from multiple symptoms. No differences in degree of secondary infections were observed between Shigella spp. and EIEC, and culture-negative and culture-positive cases.Conclusions: No convincing evidence was found to support the current guidelines that employs different measures based on species or detection method. Therefore, culture and molecular detection methods for Shigella spp. and EIEC should be considered equivalent for case definition and public health regulations regarding shigellosis. Differences were found regarding risks factors, indicating that different prevention strategies may be required. [ABSTRACT FROM AUTHOR]

Published
2019
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41. Evaluation of a Culture-Dependent Algorithm and a Molecular Algorithm for Identification of Shigellaspp., Escherichia coli, and Enteroinvasive E. coli

Author

van den Beld, Maaike J. C., de Boer, Richard F., Reubsaet, Frans A. G., Rossen, John W. A., Zhou, Kai, Kuiling, Sjoerd, Friedrich, Alexander W., and Kooistra-Smid, Mirjam A. M. D.

Abstract

Identification of Shigellaspp., Escherichia coli, and enteroinvasive E. coli(EIEC) is challenging because of their close relatedness. Distinction is vital, as infections with Shigellaspp.

Published
2018
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43. Strength in numbers: Consider joining a nonprofit board.

Author

Beld, Kyle J.

Subjects
ACCOUNTANTS, VOLUNTEER workers in nonprofit organizations, TIME management, FUNDRAISING, INTERPERSONAL relations, CAREER development
Abstract

In this article, the author talks about the benefits of working in a non profit board. He states that he is a Certified Public Accountant (CPA) and has presented views and opinions of other CPA's on such volunteering. It highlights that the benefit include exposure provided to different firms to develop their business forward and highlights that for individuals the benefits include development of time management skills, interpersonal relations and presentation skills.

Published
2012

46. Simultaneous assay of muscarinic and beta-adrenergic receptors using a double isotope technique.

Author

van Koppen CJ, Siero HL, Rodrigues de Miranda JF, Beld AJ, and Ariëns EJ

Subjects
Animals, Cattle, Iodine Radioisotopes, Iodocyanopindolol, Methods, Pindolol metabolism, Receptors, Adrenergic, beta metabolism, Receptors, Muscarinic metabolism, Tritium, Pindolol analogs & derivatives, Quinuclidines metabolism, Quinuclidinyl Benzilate metabolism, Receptors, Adrenergic, beta analysis, Receptors, Muscarinic analysis, Trachea analysis
Abstract

Muscarinic receptor and beta-adrenergic receptor binding were measured simultaneously in a membrane fraction of bovine tracheal smooth muscle using [3H]-L-quinuclidinyl benzilate and [125I]-(-) iodocyanopindolol. The binding characteristics, affinity and receptor density, obtained in the double receptor assay and in the control experiments were the same within experimental error. Moreover, there appears to be neither a significant influence of an excess of d,1-propranolol on [3H]-L-quinuclidinyl benzilate binding nor a significant influence of an excess of 1-quinuclidinyl benzilate on [125I]-(-)iodocyanopindolol binding. The method is advantageous where both receptors have to be assayed and where limited amounts of biological material, like in biopsy specimen, are available.

Published
1984
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47. Quantitative correlations between chemical structure and affinity for acetylcholine receptors.

Author

Lien EJ, Ariëns EJ, and Beld AJ

Subjects
Animals, Binding Sites, Chemical Phenomena, Chemistry, Physical, Guinea Pigs, Ileum drug effects, In Vitro Techniques, Mathematics, Muscle Contraction drug effects, Muscle, Smooth drug effects, Parasympatholytics, Quaternary Ammonium Compounds pharmacology, Regression Analysis, Structure-Activity Relationship, Acetylcholine, Quaternary Ammonium Compounds metabolism, Receptors, Cholinergic
Abstract

The affinity constants (log K, pA2) of 128 quaternary ammonium compounds belonging to several different series have been correlated linearly with the hydrophobicity (piR) constant, the dipole moment (muR), and the number of hydroxyl groups (nOH) of the side chain; the dependence on the hydrophobicity constant of the quaternary ammonium head (pi-N identical to) is shown to be parabolic. A correlation coefficient of 0.96 is obtained for all the compounds using only 4 independent variables (6 terms). Based on the quantitative correlation obtained, intermolecular forces involved in the drug-receptor interaction are discussed. Further molecular modifications to enhance the affinity to cholinergic receptors are suggested.

Published
1976
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49. The influence of neuropharmaca on the nasal glands. Preliminary report.

Author

Klaassen AB, Kuijpers W, Rodrigues de Miranda JF, and Beld AJ

Subjects
Animals, Atropine pharmacology, Carbachol pharmacology, Methacholine Chloride, Methacholine Compounds pharmacology, Nasal Mucosa metabolism, Parasympathetic Nervous System physiology, Pilocarpine pharmacology, Rats, Reserpine pharmacology, Nasal Mucosa drug effects, Parasympatholytics pharmacology, Parasympathomimetics pharmacology
Abstract

Contributions from various sources to the nasal fluid are a serious complicating factor for investigating the isolated role of the nasal glands in the production of this fluid. This study is an attempt to obtain a better insight in the secretory behaviour of the nasal glands and its neural regulation. Radioligand binding strongly suggests that rat nasal glands contain muscarinic receptors. Parasympathomimetic drugs mainly promote the discharge of the secretory proteins from the glandular cells. However, histological sections do not show any change in the number of secretory granules after parasympatholytic drug application. These observations refer to a complex nature of the parasympathetic regulation of the glandular secretory activity.

Published
1985

50. Inhibition of [3H]dexetimide binding by a homologous series of methylfurthrethonium analogues at the peripheral muscarinic receptor.

Author

Beld AJ, Klok EJ, and Rodrigues de Miranda JF

Subjects
Animals, Binding, Competitive, Cattle, Cell Membrane metabolism, Kinetics, Structure-Activity Relationship, Trachea metabolism, Dexetimide metabolism, Muscle, Smooth metabolism, Piperidines metabolism, Receptors, Cholinergic metabolism, Receptors, Muscarinic metabolism
Published
1980
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