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2. Orexigenic neuropeptide 26RFa: new evidence for an adaptive profile of appetite regulation in anorexia nervosa

Author

Fauquembergue, Emilie, Toutirais, Olivier, Tougeron, David, Drouet, Aurélie, Le Gallo, Matthieu, Desille, Mireille, Cabillic, Florian, De La Pintière, Cécile Thomas, Iero, Manuela, Rivoltini, Licia, Baert-Desurmont, Stéphanie, Vaudry, Hubert, Sesboüe, Richard, Frebourg, Thierry, Latouche, Jean-Baptiste, Catros, Véronique, Gach, D, Belkacemi, D, Lefranc, R, Perlikowski, D, Masson, J., Walet-Balieu, R, Do-Rego, J., Galas, R, Schapman, D., Lamtahri, D, Tonon, D, Vaudry, D., Chuquet, J., Gach, K., Belkacemi, O., Lefranc, B., Perlikowski, P., Walet-Balieu, M.-L., Galas, L., Lamtahri, R., Tonon, M.-C., Galusca, Bogdan, Jeandel, Lydie, Germain, Natacha, Alexandre, David, Leprince, Jérôme, Anouar, Youssef, Estour, Bruno, Chartrel, Nicolas, Biothérapies Innovantes, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), CRLCC Eugène Marquis (CRLCC), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Service de Cytogénétique et de Biologie Cellulaire, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori-IRCCS Foundation, Génétique médicale et fonctionnelle du cancer et des maladies neuropsychiatriques, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuroendocrinologie cellulaire et moléculaire, Génétique du cancer et des maladies neuropsychiatriques (GMFC), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Différenciation et communication neuronale et neuroendocrine (DC2N), Endocrinologie, Centre Hospitalier Universitaire de Saint-Etienne, Université de Rennes - Faculté de Médecine (UR Médecine), Université de Rennes (UR), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)

Subjects
food intake, Anorexia Nervosa, Endocrinology, Diabetes and Metabolism, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Clinical Biochemistry, Appetite, diazepam-binding inhibitor, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, MESH: Neuropeptides, Biochemistry, 0302 clinical medicine, Endocrinology, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Medicine, Bulimia, media_common, 2. Zero hunger, 0303 health sciences, digestive, oral, and skin physiology, MESH: Energy Metabolism, anxiety, Adaptation, Physiological, Ghrelin, Circadian Rhythm, Eating disorders, Anorexia nervosa (differential diagnoses), MESH: Young Adult, Female, medicine.symptom, MESH: Anorexia Nervosa, hormones, hormone substitutes, and hormone antagonists, MESH: Malnutrition, Binge-Eating Disorder, medicine.drug, Adult, medicine.medical_specialty, phosphorylated peptide, MESH: Rats, Adolescent, media_common.quotation_subject, MESH: Ghrelin, 030209 endocrinology & metabolism, Context (language use), 03 medical and health sciences, endozepines, Young Adult, MESH: Cross-Sectional Studies, Internal medicine, Orexigenic, Humans, Circadian rhythm, MESH: Bulimia, MESH: Circadian Rhythm, 030304 developmental biology, MESH: Adolescent, MESH: Humans, Binge eating, business.industry, Biochemistry (medical), Malnutrition, Neuropeptides, MESH: Adult, MESH: Binge-Eating Disorder, medicine.disease, MESH: Adaptation, Physiological, Cross-Sectional Studies, octadecaneuropeptide, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, MESH: Appetite, business, Energy Metabolism, MESH: Female
Abstract

Restrictive anorexia nervosa (AN) presents an adaptive appetite regulating profile including mainly high levels of ghrelin. Because this adaptive mechanism is not effective on food intake, other appetite-regulating peptides need to be explored. 26RFa is a hypothalamic neuropeptide that stimulates appetite, gonadotropin release, and bone metabolism.The objective of the study was to evaluate the circadian levels of 26RFa in AN patients compared with healthy subjects, other eating disorders, and constitutional thinness (CT).This was a cross-sectional study performed in an endocrine unit and an academic laboratory.Five groups of age-matched young women were included in the study: 19 restrictive AN, 10 AN with bingeing/purging episodes, 14 with CT, 10 bulimic, and 10 normal-weight controls.Twelve-point circadian profiles of plasma 26RFa levels were measured in each subject.Significant circadian variations of 26 RFA were noticed in controls with higher values in the morning and abrupt decrease at noon. Twenty-four-hour mean 26RFa levels were significantly increased in restrictive AN and AN with bingeing/purging episodes (P0.001), predominantly in the afternoon and evening when compared with controls. Preprandial rises of 26 RFA were noticed in AN patients. Mean 26RFa levels trend to be higher in CT than in controls (P = 0.06) and significantly lower than in AN. The bulimic patients presented a circadian profile of 26RFa similar to that of controls.High levels of circulating 26RFa observed in AN patients might reflect an adaptive mechanism of the organism to promote energy intake and to increase fat stores in response to undernutrition.

Published
2012
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