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1. Post-walking exercise skeletal muscle perfusion and energetics in patients with symptomatic lower extremity peripheral artery disease

Author

Divakaran, Sanjay, Harms, Hendrik J., Robertson, Matthew, Merugumala, Sai K., Park, Mi-Ae, Kijewski, Marie F., Martell, Laurel B., Morgan, Victoria, Barrett, Leanne, Perillo, Anna, Yang, David, Jarolim, Petr, Feinberg, Mark W., Gerhard-Herman, Marie D., Belkin, Michael, Lin, Alexander P., Creager, Mark A., Bonaca, Marc P., and Di Carli, Marcelo F.

Published
2025
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3. Looper: An end-to-end ML platform for product decisions

Author

Markov, Igor L., Wang, Hanson, Kasturi, Nitya, Singh, Shaun, Yuen, Sze Wai, Garrard, Mia, Tran, Sarah, Huang, Yin, Wang, Zehui, Glotov, Igor, Gupta, Tanvi, Huang, Boshuang, Chen, Peng, Xie, Xiaowen, Belkin, Michael, Uryasev, Sal, Howie, Sam, Bakshy, Eytan, and Zhou, Norm

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Software Engineering
Abstract

Modern software systems and products increasingly rely on machine learning models to make data-driven decisions based on interactions with users, infrastructure and other systems. For broader adoption, this practice must (i) accommodate product engineers without ML backgrounds, (ii) support finegrain product-metric evaluation and (iii) optimize for product goals. To address shortcomings of prior platforms, we introduce general principles for and the architecture of an ML platform, Looper, with simple APIs for decision-making and feedback collection. Looper covers the end-to-end ML lifecycle from collecting training data and model training to deployment and inference, and extends support to personalization, causal evaluation with heterogenous treatment effects, and Bayesian tuning for product goals. During the 2021 production deployment Looper simultaneously hosted 440-1,000 ML models that made 4-6 million real-time decisions per second. We sum up experiences of platform adopters and describe their learning curve., Comment: 11 pages + references, 7 figures; to appear in KDD 2022

Published
2021

6. Binocular Home Treatment for Amblyopia: Gains Stable for One Year

Author

Spierer, Abraham, Wygnanski-Jaffe, Tamara, Zitzer, Nethanel, Cohen, Dan, Shpigelman, Ahuva, Hadash, Maoz, Ortenberg, Ilya, Cohen, Rinat, Leib, Hana, Arow, Majd, Parness, Reut, Rodov, Luba, Goz, Alexandra, Katz, Haia, Bazov, Anabel, Nissen, Chaim, Avraham, Gabriel, Borsha, Emad, Keynann, Idit, Aviv, Tali, Corcos, Nathalie, Roll, Keren, Mezer, Eedy, Brucker, Vered, Abecassis, Meital, Rabinovich, Ronen, Laster, Eran, Politi, Ronit, Givoni, Hila, Amitirat, Ahed, Barrett, Chiya Robert, Zioni, Adelina, Kuperman, Katty, Crocos, Yael, Moshkovitz, Avital, Kushner, Burton J., Belkin, Michael, and Yehezkel, Oren

Published
2024
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7. Quality of Life in Patients With Chronic Limb-Threatening Ischemia Treated With Revascularization

Author

Menard, Matthew T., Farber, Alik, Powell, Richard J., Rosenfield, Kenneth, Conte, Michael S., Hamza, Taye H., Kaufman, John A., Cziraky, Mark J., Creager, Mark A., Dake, Michael D., Jaff, Michael R., Reid, Diane, Sopko, George, White, Christopher J., Strong, Michael B., van Over, Max, Chisci, Emiliano, Goodney, Philip P., Gray, Bruce, Kayssi, Ahmed, Siracuse, Jeffrey J., Choudhry, Niteesh K., Maurao, Mick, Muluk, Satish, Belkin, Michael, Lyden, Sean, Shishehbor, Mehdi, Bajakian, Danielle, Duwayri, Yazan, Bowens, Nina, Nypaver, Timothy, Mukherjee, Dipankar, Obrand, Daniel, LaMuraglia, Glenn, Kalra, Manju, Bernardo, Nelson, Barshes, Neal, Lipsitz, Evan, Jenkins, J. Stephen, Gasper, Warren, Owens, Christopher, Pomposelli, Frank, Rogers, Kevin, Vouyouka, Ageliki, Passman, Marc, Pena, Constantino, Ramaiah, Venkatesh, Hoch, John, Bersin, Robert, Hayes, Greg, Ho, Karen, Shah, Aamir, Lum, Ying Wie, Darling, R. Clement, III, Aalami, Oliver, Zhou, Wei, Patel, Parag, Aziz, Abdulhameed, Halloran, Brian, Jung, Enjae, Mitchell, Erica, Turba, Ulku Cenk, Choi, Eric, Hiramoto, Jade, Owens, Christopher, Milner, Ross, Crawford, Robert, Ucuzian, Areck, Henke, Peter, Chaer, Rabih, Lahiri (Adams), Julie, Gelabert, Hugh, Safian, Robert, Mena-Hurtado, Carlos, Ihnat, Daniel, Rowe, Vincent, Kashyap, Vikram, Shaw, Palma, Korngold, Ethan, Lindsay, Thomas, Winkelaar, Gerrit, Mell, Matthew, DuVal, Bruce, Aziz, Faisal, Reed, Amy, Nazzal, Munier, Schanzer, Andres, Hamdan, Allen, Smeds, Matthew, Kalish, Jeffrey, Slaiby, Jeffrey, Androes, Mark, Hanover, Tod, Motaganahalli, Raghu, Chang, Catherine, Hye, Robert, Alexander, Jason, Ansel, Gary, Bohannon, Todd, Desai, Sapan, Hodgson, Kim, Hood, Douglas, Guzman, Randolph Pl, Giles, Kristina, Shah, Samir, Hawkins, Beau, Brothers, Thomas Edward, Azizzadeh, Ali, Charlton-Ouw, Kristofer, Khan, Sophia, Brooke, Benjamin S., Kabutey, Nii-Kabu, Sachar, Ravish, Dosluoglu, Hasan, Berman, Scott, Blebea, John, Taubman, Kevin, Douville, Yvan, Cox, Mitchell W., Davis, Joseph, Caps, Michael, Schneider, Peter, Abou-Zamzam, Ahmed, Feldman, Robert, von Mering, Gregory, Tan, Tze-Woei, Virk, Chiranjiv S., Zhang, Wayne, Bacharach, Michael, Seidman, Craig, Iafrati, Mark, Findeiss, Laura, Bailey, Charles, Shames, Murray, Lane, John, Baril, Donald, Hass, Stephen, Stone, Patrick, Sharma, Aditya, Tracci, Margaret, Mackenzie, Kent, Stoner, Michael, Starr, Jean, McAllister, David, Singh, Niten, Tsai, Shirling, Kinlay, Scott, Macsata, Robyn, Neville, Richard, Rundback, John, McGinigle, Kate, Vallabhaneni, Raghu, Espinoza, Andrey, Azarbal, Amir, Longo, G. Matthew, Kovach, Richard, Soukas, Peter, Metzger, Chris, Artis, Andre, Bachinsky, William, Armstrong, Ehrin, Hattler, Brack, Chandra, Venita, Schor, Jonathan, Bianchi, Christian, Kiang, Sharon, Ben-Arie, Eyal, Verta, Michael, Wilkinson, Julia, Hurie, Justin, Kopriva, David, Molnar, Robert, Chun, Linda Jun, Azene, Ezana, Davis, Clark, Blazick, Elizabeth, Henao, Steve, Proffitt, Trent, Herman, Christine, Nathan, Derek, Chang, Robert, Lane, John, Mureebe, Leila, Chen, Jerry, Semel, Marcus, Fecteau, Scott, Mehta, Manish, Nagpal, Sudhir, Shammas, Nicolas, Kujath, Scott, Beasley, Robert, Vogel, Todd, Hedayati, Nasim, Brooks, James, Nelson, Peter, Parrack, Inkyong, Bernik, Thomas, Dexter, David, Brown, Kellie, Huang, Joe, Wu, Timothy, Hacker, Robert, Garland, Brandon Tyler, Griffin, Joseph, Laskowski, Igor, Pfau, Steven, Duncan, Audra, Trachtenberg, Jeffrey, Gordon, Ian, Tan, Tze-Woei, Aulivola, Bernadette, Zayed, Mohamed, Venermo, Maarit, Hill, Andrew, Wickremesekera, Janaka Kesara, Ketteler, Erika, Michelagnoli, Stefano, Bannazadeh, Mohsen, Sikalas, Nicholas, Khashram, Manar, Vasudevan, Thodur, Simmons, Justin, Osborne, Nicholas, Fox, Charles, and Vallabhaneni, Raghuveer

Published
2024
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8. An Eye-Tracking–Based Dichoptic Home Treatment for Amblyopia: A Multicenter Randomized Clinical Trial

Author

Gan, Ramat, Spierer, Abraham, Wygnanski-Jaffe, Tamara, Zitzer, Nethanel, Cohen, Dan, Shpigelman, Ahuva, Hadash, Maoz, Ortenberg, Ilya, Cohen, Rinat, Leib, Hana, Arow, Majd, Parness, Reut, Rodov, Luba, Goz, Alexandra, Katz, Haia, Bazov, Anabel, Nissen, Chaim, Avraham, Gabriel, Borsha, Emad, Keynann, Idit, Aviv, Tali, Corcos, Nathalie, Roll, Keren, Mezer, Eedy, Brucker, Vered, Abecassis, Meital, Rabinovich, Ronen, Laster, Eran, Politi, Ronit, Givoni, Hila, Amitirat, Ahed, Barrett, Chiya Robert, Zioni, Adelina, Kuperman, Katty, Crocus, Yael, Kushner, Burton J., Moshkovitz, Avital, Belkin, Michael, and Yehezkel, Oren

Published
2023
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10. Grand Challenges in global eye health: a global prioritisation process using Delphi method

Author

Aghaji, Ada, Adewole, Adeyemi T, Csutak, Adrienne, Salam, Ahmad Shah, Paduca, Ala, Bron, Alain M, Denniston, Alastair K, Lazo Legua, Alberto, Halim, Aldiana, Tefera, Alemayehu Woldeyes, Mwangi, Alice, Jenkins, Alicia J, Davis, Amanda, Meddeb-Ouertani, Amel, Wali, Amina H, Palis, Ana G, Bastos de Carvalho, Ana, Joshi, Anagha, Kreis, Andreas J, Mueller, Andreas, Bastawrous, Andrew, Cooper, Andrew, Smith, Andrew F, Grzybowski, Andrzej, Arvind, Anitha, Karanu, Anne M, Orlina, Anne O, Burnett, Anthea, Yashadhana, Aryati, Abeydeera, Asela P, Abdurakhmanova, Aselia, Mohamed, Ashik, Bacchav, Ashish, Bernhisel, Ashlie, Webson, Aubrey Walton, Azuara-Blanco, Augusto, Hossain, Ava, Ilhan, Bayazit, Assumpta Lucienne, Bella, Tousignant, Benoit, Shamanna, Bindiganavale R, Wiafe, Boateng, Mueller, Brigitte, Caglar, Cagatay, Mpyet, Caleb, Abraham, Carl H, Cheung, Carol Y, Thiel, Cassandra L, Jan, Catherine L, Emedike, Chike, Chuluunkhuu, Chimgee, Chinyere, Chinomso, Henein, Christin, Gilbert, Clare E, Bascaran, Covadonga, Nitulescu, Cristina Elena, Patel, Daksha, Bachani, Damodar, Kiage, Daniel, Etya'ale, Daniel, Dahdal, David, Woo Lawson, Dawn, Godin, Denise, Nkanga, Dennis G, Ondeyo, Dennis M, O'Brien, Donna, Mutie, Dorothy M, Alalawi, Ebtisam S K, Mayorga, Eduardo, Bin Hashim, Effendy, Ashrafi, Elham, Kishiki, Elizabeth Andrew, Kurian, Elizabeth, D'Esposito, Fabrizio, Masila, Faith, Pena, Fernando Yaacov, Büsch, Fortunat, Topouzis, Fotis, Bandello, Francesco, Oyediji, Funmilayo J, Thumann, Gabriele, Ezz Elarab, Gamal, Kitema, Gatera Fiston, Schlenther, Gerhard, Fefoame, Gertrude Oforiwa, Cochrane, Gillian M, Laganovska, Guna, Awan, Haroon R, Ansari, Harris M, Philippin, Heiko, Burn, Helen, Dimaras, Helen, Filipe, Helena P, Monye, Henrietta I, Kandel, Himal, Randrianarisoa, Hoby Lalaina, Jones, Iain, Murdoch, Ian E, Fabian, Ido Didi, Khan, Imran A, Sharma, Indra P, Elbeih, Islam, Mactaggart, Islay, Pastor, J Carlos, Keunen, Jan E E, Ohuma, Jane A, Pithuwa Nirwoth, Jason, Hammou, Jaouad, Vianna, Jayme R, Biao, Jean-eudes, Burr, Jennifer M, Keenan, Jeremy D, Blijkers, Jess, Black, Joanna M, Barbosa Breda, Joao, Furtado, Joao M, Buchan, John C, Lawrenson, John G, Kempen, John H, Ehrlich, Joshua R, Stern, Judith, Zhang, Justine H, Keskinbora, Kadircan H, Knoll, Karin M, Blanchet, Karl, Schmid, Katrina L, Ono, Koichi, Ogundimu, Kolawole, Balo, Komi, Somda, Kussome Paulin, Yeboah, Kwame, Amissah-Arthur, Kwesi N, Nasehi, Leone, Øverland, Lene, Vijaya, Lingam, Keay, Lisa, Hamm, Lisa M, Mowatt, Lizette, Harrison-Williams, Lloyd C M, Silva, Lucia, Bilotto, Luigi, Mörchen, Manfred, Rabiu, Mansur, Zondervan, Marcia, Chagunda, Margarida, Sandinha, Maria Teresa, Yee Melgar, Mariano, Salas Vargas, Marisela, Daniell, Mark D, Katibeh, Marzieh, Broom, Matt, Collins, Megan E, Alp, Mehmet Numan, Kwarteng, Michael A, Belkin, Michael, Gichangi, Michael, Sylvanowicz, Michelle, Wu, Min, Cano, Miriam R, Shalaby, Mohammad, Duggal, Mona, Khairallah, Moncef, Batur, Muhammed, Bikbov, Mukharram M, Ramappa, Muralidhar, Pamarathi, Nagaraju, Khachatryan, Naira, Muhammad, Nasiru, Kennedy, Neil, Murray, Neil, Beare, Nicholas A V, Astbury, Nick, Carnt, Nicole A, St Rose, Nigel A, Barker, Nigel H, Pehere, Niranjan K, Uche, Nkechinyere J, Lois, Noemi, Awe, Oluwaseun O, Mujica, Oscar J, Okolo, Oteri E, Rani, Padmaja Kumari, Ruamviboonsuk, Paisan, Ndiaye, Papa Amadou, Dhakhwa, Parami, Rozsival, Pavel, Mbulawa, Pearl K, Keane, Pearse A, Jones, Pete R, Holland, Peter, Nukella, Phanindra Babu, Burgess, Philip I, O'Dwyer, Pinar Aydin, Piyasena, Prabhath, Bastola, Pradeep, Morjaria, Priya, Nasimee, Qais, Rambacal, Raizza A T, Das, Rajdeep, Khandekar, Rajiv B, Azad, Rajvardhan, Bashshur, Ramona, Sousa, Raúl A R C, Oenga, Rebecca, Gurung, Reeta, Geneau, Robert, Jacobs, Robert J, Finger, Robert P, Guymer, Robyn H, Sevciuc, Rodica, Khanna, Rohit C, George, Ronnie, Graham, Ronnie, Kawasaki, Ryo, Ho, S May, Mishra, Sailesh Kumar, Buttan, Sandeep, Block, Sandra S, Talero, Sandra, Yoon, Sangchul, Joseph, Sanil, Safi, Sare, Dodson, Sarity, Munoz, Sergio R, Bakayoko, Seydou, Mohammadi, Seyed Farzad, Muez, Shabir Ahmad, Pardhan, Shahina, Hopkins, Shelley, Sheu, Shwu-Jiuan, Coulibaly, Sidi Mohamed, Schellini, Silvana A, Arunga, Simon, Bush, Simon R, Sivaprasad, Sobha, Salomao, Solange R, Marmamula, Srinivas, Onwubiko, Stella N, Misra, Stuti L, Kuyyadiyil, Subeesh, Kulkarni, Sucheta, khanal, Sudarshan, Yasmin, Sumrana, Pavljasevic, Suzana Nikolic, Gilbert, Suzanne S, Braithwaite, Tasanee, Ghidirimschi, Tatiana, Ravilla, Thulasiraj, Fricke, Timothy R, Cogliati, Tiziana, Kassa, Tsehaynesh, Peto, Tunde, Dibb, Ute, Lansingh, Van C, Hu, Victor H, Sheffield, Victoria M, Mathenge, Wanjiku, Dean, William H, Nolan, Winifred, Hiratsuka, Yoshimune, Mahsood, Yousaf Jamal, Sapkota, Yuddha, Ramke, Jacqueline, Evans, Jennifer R, Habtamu, Esmael, Mwangi, Nyawira, Silva, Juan Carlos, Swenor, Bonnielin K, Congdon, Nathan, Faal, Hannah B, Foster, Allen, Friedman, David S, Gichuhi, Stephen, Jonas, Jost B, Khaw, Peng T, Kyari, Fatima, Murthy, Gudlavalleti V S, Wang, Ningli, Wong, Tien Y, Wormald, Richard, Yusufu, Mayinuer, Taylor, Hugh, Resnikoff, Serge, West, Sheila K, and Burton, Matthew J

Published
2022
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12. Contemporary Outcomes After Partial Resection of Infected Aortic Grafts

Author

Janko, Matthew, Hubbard, Grant, Woo, Karen, Kashyap, Vikram S., Mitchell, Megan, Murugesan, Arun, Chen, Lin, Gardner, Rachel, Baril, Donald, Hacker, Robert I., Szeberin, Zoltan, ElSayed, Ramsey, Magee, Gregory A., Motta, Fernando, Zhou, Wei, Lemmon, Gary, Coleman, Dawn, Behrendt, Christian-Alexander, Aziz, Faisal, Black, James H., Tran, Kimberly, Dao, Allen, Shutze, William, Garrett, H. Edward, De Caridi, Giovanni, Patel, Rhusheet, Liapis, Christos D., Geroulakos, George, Kakisis, John, Moulakakis, Konstantinos, Kakkos, Starvos K., Obara, Hideaki, Wang, Grace, Stoecker, Jordan, Rhéaume, Pascal, Davila, Victor, Ravin, Reid, DeMartino, Randall, Milner, Ross, Shalhub, Sherene, Jim, Jeffrey, Lee, Jason, Dubuis, Celine, Ricco, Jean-Baptiste, Coselli, Joseph, Lemaire, Scott, Fatima, Javairiah, Sanford, Jennifer, Yoshida, Winston, Schermerhorn, Marc L, Menard, Matthew, Belkin, Michael, Blackwood, Stuart, Conrad, Mark, Wang, Linda, Crofts, Sara, Nixon, Thomas, Wu, Timothy, Chiesa, Roberto, Bose, Saideep, Turner, Jason, Moore, Ryan, Smith, Justin, Irshad, Ali, Hsu, Jeffrey, Czerny, Martin, Cullen, Jonathan, Kahlberg, Andrea, Setacci, Carlo, Joh, Jin Hyun, Senneville, Eric, Garrido, Pedro, Sarac, Timur P., Rizzo, Anthony, Go, Michael R., Bjorck, Martin, Gavali, Hamid, Wanhainen, Anders, D'Oria, Mario, Lepidi, Sandro, Mastrorilli, Davide, Veraldi, Gianfranco, Piazza, Michele, Squizzato, Francesco, Beck, Adam, St. John, Rebecca, Wishy, Andrew, Humphries, Misty, Shah, Samir K., Back, Martin, Chung, Jayer, Lawrence, Peter F, Bath, Jonathan, and Smeds, Matthew R.

Published
2021
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18. A Proposal for the Use of a Fixed Low-Energy Selective Laser Trabeculoplasty for Open Angle Glaucoma

Author

Sacks, Zachary, Katz, L. Jay, Gazzard, Gus, Van Tassel, Sarah H., Blumenthal, Eytan Z., Lerner, Fabian S., Azuara-Blanco, Augusto, Spooner, Gregory John Roy, Solberg, Yoram, Samuelson, Thomas, Belkin, Michael, Sacks, Zachary, Katz, L. Jay, Gazzard, Gus, Van Tassel, Sarah H., Blumenthal, Eytan Z., Lerner, Fabian S., Azuara-Blanco, Augusto, Spooner, Gregory John Roy, Solberg, Yoram, Samuelson, Thomas, and Belkin, Michael

Abstract

Selective laser trabeculoplasty (SLT) has been in routine clinical use for over 20 years with millions of patients successfully treated and a low rate of clinically significant complications. The procedure requires the clinician to manually position the laser beam on the trabecular meshwork using a gonioscopy lens and to titrate the SLT laser energy based on the amount of pigmentation in the angle, as well as the observation of small bubbles produced by the laser effect. We propose that SLT energy titration is unnecessary either to achieve intraocular pressure (IOP) reduction or to minimize potential side effects. Ample evidence to support our proposal includes multiple clinical reports demonstrating comparable levels of IOP reduction resulting from different laser energies, a large variety of energy and other laser parameters used in commercially available SLT lasers, and the nature of the laser-induced changes in the trabecular meshwork tissue with respect to energy. Despite these variations in laser parameters, SLT consistently reduces IOP with a low complication rate. We propose that using low fixed energy for all patients will effectively and safely lower patients' IOP while reducing the complexity of the SLT procedure, potentially making SLT accessible to more patients.

Published
2024

21. A single nucleotide polymorphism in the p27Kip1 gene is associated with primary patency of lower extremity vein bypass grafts

Author

Conte, Michael S, Owens, Christopher D, Belkin, Michael, Creager, Mark A, Edwards, Karen L, Gasper, Warren J, Kenagy, Richard D, LeBoeuf, Renee C, Sobel, Michael, and Clowes, Alexander

Subjects
Bioengineering, Cardiovascular, Genetics, Clinical Research, Aged, Critical Illness, Cyclin-Dependent Kinase Inhibitor p27, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Graft Occlusion, Vascular, Humans, Intermittent Claudication, Ischemia, Lower Extremity, Male, Middle Aged, Multivariate Analysis, Peripheral Arterial Disease, Phenotype, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Proportional Hazards Models, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Ultrasonography, Doppler, Duplex, United States, Vascular Grafting, Vascular Patency, Veins, Medical and Health Sciences, Cardiovascular System & Hematology
Abstract

ObjectiveFactors responsible for the variability in outcomes after lower extremity vein bypass grafting (LEVBG) are poorly understood. Recent evidence has suggested that a single nucleotide polymorphism (SNP) in the promoter region of the p27(Kip1) gene, a cell-cycle regulator, is associated with coronary in-stent restenosis. We hypothesized an association with vein graft patency.MethodsThis was a retrospective genetic association study nested within a prospective cohort of 204 patients from three referral centers undergoing LEVBG for claudication or critical ischemia. The main outcome measure was primary vein graft patency.ResultsAll patients were followed up for a minimum of 1 year with duplex graft surveillance (median follow-up, 893 days; interquartile range, 539-1315). Genomic DNA was isolated and SNP analysis for the p27(Kip1)-838C>A variants was performed. Allele frequencies were correlated with graft outcome using survival analysis and Cox proportional hazards modeling. The p27(Kip1)-838C>A allele frequencies observed were CA, 53%; CC, 30%; and AA, 17%, satisfying Hardy-Weinberg equilibrium. Race (P = .025) and history of coronary artery disease (P = .027) were different across the genotypes; all other baseline variables were similar. Primary graft patency was greater among patients with the -838AA genotype (75% AA vs 55% CA/CC at 3 years; P = .029). In a Cox proportional hazards model including age, sex, race, diabetes, critical limb ischemia, redo (vs primary) bypass, vein type, and baseline C-reactive protein level, the p27(Kip1)-838AA genotype was significantly associated with higher graft patency (hazard ratio for failure, 0.4; 95% confidence interval, 0.17-0.93). Genotype was also associated with early (0-1 month) changes in graft lumen diameter by ultrasound imaging.ConclusionsThese data suggest that the p27(Kip1)-838C>A SNP is associated with LEVBG patency and, together with previous reports, underscore a central role for p27(Kip1) in the generic response to vascular injury.

Published
2013

22. Thirty-day vein remodeling is predictive of midterm graft patency after lower extremity bypass

Author

Gasper, Warren J, Owens, Christopher D, Kim, Ji Min, Hills, Nancy, Belkin, Michael, Creager, Mark A, and Conte, Michael S

Subjects
Clinical Research, Cardiovascular, Aged, Biomarkers, Boston, C-Reactive Protein, Female, Genetic Testing, Graft Occlusion, Vascular, Humans, Inflammation Mediators, Kaplan-Meier Estimate, Linear Models, Longitudinal Studies, Lower Extremity, Male, Middle Aged, Multivariate Analysis, Peripheral Arterial Disease, Proportional Hazards Models, Prospective Studies, Time Factors, Treatment Outcome, Ultrasonography, Doppler, Duplex, Vascular Patency, Veins, Medical and Health Sciences, Cardiovascular System & Hematology
Abstract

ObjectiveSuccessful adaptation of a vein graft to an arterial environment is incompletely understood. We sought to investigate whether early vein graft remodeling is predictive of subsequent patency.MethodsA prospective longitudinal study was conducted of 67 patients undergoing lower extremity bypass with autogenous vein between February 2004 and April 2008. Preoperative blood samples were drawn for biomarkers. During the bypass operation, a 5-cm index segment of the graft was registered for serial lumen diameter measurements at 0, 1, 3, 6, 9, and 12 months using duplex ultrasound imaging. The imaging substudy analysis included patients with at least two ultrasound assessments.ResultsPatients (55% male) were a median age of 70 years (interquartile range [IQR], 59-76 years), 40% had diabetes mellitus, 49% had critical limb ischemia, 75% were taking a statin, and 91% were taking an antiplatelet medication. Median follow-up was 32 months (IQR, 15-47 months). The median baseline high-sensitivity C-reactive protein level (hsCRP) was 3.2 mg/L (IQR, 1.4-9.7 mg/L). The average intraoperative, postimplantation vein lumen diameter was 3.9±1.0 mm, increasing to 4.7±1.1 mm at 1 month, an average 24%±27% change per patient. By 3 months, the average lumen diameter was 5.1±1.6 mm, with little subsequent change observed to 12 months. Nonwhite race, baseline hsCRP ≥5 mg/L, statin use, and initial lumen diameter were significantly associated with early (0- to 1-month) vein remodeling in a multivariable regression model. The primary patency rate for the cohort was 60%±6.3% at 2 years. Initial lumen diameter of the index segment was not associated with primary patency, whereas larger lumen diameter achieved at 1 month (≥5.1 mm) was positively associated with primary patency (log-rank, P=.03). Early (30-day) remodeling behavior was used to divide patients into "poor remodelers" (+25% change, n=30). Early remodeling category was significantly associated with primary patency rate at 2 years (log-rank, P=.02). A multivariable Cox proportional hazards model showed that modest remodelers (hazard ratio, 3.9; 95% confidence interval, 1.02-15; P=.04) and poor remodelers (hazard ratio, 13; 95% confidence interval; P=.008) had significantly higher hazard ratios for graft failure than robust early remodelers.ConclusionsEarly remodeling of the arterialized vein appears to predict midterm bypass graft patency. In addition to baseline diameter, race, inflammation, hsCRP, and statin use are associated with early adaptive remodeling, but the mechanisms for these observations are not understood.

Published
2013

23. Irreversible electroporation of human primary uveal melanoma in enucleated eyes.

Author

Mandel, Yossi, Laufer, Shlomi, Belkin, Michael, Rubinsky, Boris, Pe'er, Jacob, and Frenkel, Shahar

Subjects
Eye, Humans, Melanoma, Uveal Neoplasms, Eye Enucleation, Electroporation, Aged, Aged, 80 and over, Middle Aged, Female, Ablation Techniques, General Science & Technology
Abstract

Uveal melanoma (UM) is the most common primary intraocular tumor in adults and is characterized by high rates of metastatic disease. Although brachytherapy is the most common globe-sparing treatment option for small- and medium-sized tumors, the treatment is associated with severe adverse reactions and does not lead to increased survival rates as compared to enucleation. The use of irreversible electroporation (IRE) for tumor ablation has potential advantages in the treatment of tumors in complex organs such as the eye. Following previous theoretical work, herein we evaluate the use of IRE for uveal tumor ablation in human ex vivo eye model. Enucleated eyes of patients with uveal melanoma were treated with short electric pulses (50-100 µs, 1000-2000 V/cm) using a customized electrode design. Tumor bioimpedance was measured before and after treatment and was followed by histopathological evaluation. We found that IRE caused tumor ablation characterized by cell membrane disruption while sparing the non-cellular sclera. Membrane disruption and loss of cellular capacitance were also associated with significant reduction in total tumor impedance and loss of impedance frequency dependence. The effect was more pronounced near the pulsing electrodes and was dependent on time from treatment to fixation. Future studies should further evaluate the potential of IRE as an alternative method of uveal melanoma treatment.

Published
2013

24. Sex-based differences in the inflammatory profile of peripheral artery disease and the association with primary patency of lower extremity vein bypass grafts

Author

Hiramoto, Jade S, Owens, Christopher D, Kim, Ji Min, Boscardin, John, Belkin, Michael, Creager, Mark A, and Conte, Michael S

Subjects
Cardiovascular, Clinical Research, Heart Disease, Aged, C-Reactive Protein, Female, Fibrinogen, Humans, Male, Middle Aged, Multivariate Analysis, Peripheral Arterial Disease, Proportional Hazards Models, Prospective Studies, Sex Factors, Vascular Patency, Vascular Surgical Procedures, Medical and Health Sciences, Cardiovascular System & Hematology
Abstract

ObjectiveThis study was conducted to determine if there are sex-based differences in the inflammatory phenotype of patients undergoing lower extremity bypass (LEB) and if they correlate with clinical outcomes.MethodsThis was a retrospective analysis of a prospective cohort of 225 patients (161 men and 64 women) who underwent autogenous vein LEB between February 2004 and May 2008. Fasting baseline blood samples were obtained before LEB, and the inflammatory biomarkers high-sensitivity C-reactive protein (CRP) and fibrinogen were assessed. All patients underwent ultrasound graft surveillance. CRP levels were dichotomized at 5 mg/L and fibrinogen levels at 600 mg/dL.ResultsThere were no significant differences in age, race, history of hypertension or diabetes mellitus, body mass index, or coronary artery disease between men and women. Men were more likely to be current smokers (P = .02), have a history of hypercholesterolemia (P = .02), and be taking statins (P = .02). Women were more likely to present with critical limb ischemia (P = .03) and had higher median baseline CRP levels (5.15 mg/L; interquartile range [IQR], 1.51-18.62 mg/L) than men (2.70; IQR, 1.24-6.98 mg/L; P = .02). Median follow-up was 893 days (IQR, 539-1315 days). A multivariable Cox proportional hazards model for primary vein graft patency showed a significant interaction between sex and CRP (P = .03) and fibrinogen (P = .02). After adjustment for key covariates, primary vein graft patency was significantly less in women with CRP >5 mg/L compared with women with CRP 600 mg/dL vs women with fibrinogen

Published
2012

28. Contextualizing BEST-CLI with Real-world Vein Mapping Practice Patterns before Endovascular Treatment of Chronic Limb-threatening Ischemia

Author

Heindel, Patrick, primary, Fitzgibbon, James J., additional, McKie, Kerri, additional, Goudreau, Bernadette, additional, Dieffenbach, Bryan V., additional, Aicher, Brittany, additional, Belkin, Michael, additional, Farber, Alik, additional, Menard, Matthew T., additional, and Hussain, Mohamad A., additional

Published
2023
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30. Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence

Author

Daiello, Lori A., Racine, Annie M., Yun Gou, Ray, Marcantonio, Edward R., Xie, Zhongcong, Kunze, Lisa J., Vlassakov, Kamen V., Inouye, Sharon K., Jones, Richard N., Alsop, David, Travison, Thomas, Arnold, Steven, Cooper, Zara, Dickerson, Bradford, Fong, Tamara, Metzger, Eran, Pascual-Leone, Alvaro, Schmitt, Eva M., Shafi, Mouhsin, Cavallari, Michele, Dai, Weiying, Dillon, Simon T., McElhaney, Janet, Guttmann, Charles, Hshieh, Tammy, Kuchel, George, Libermann, Towia, Ngo, Long, Press, Daniel, Saczynski, Jane, Vasunilashorn, Sarinnapha, O’Connor, Margaret, Kimchi, Eyal, Strauss, Jason, Wong, Bonnie, Belkin, Michael, Ayres, Douglas, Callery, Mark, Pomposelli, Frank, Wright, John, Schermerhorn, Marc, Abrantes, Tatiana, Albuquerque, Asha, Bertrand, Sylvie, Brown, Amanda, Callahan, Amy, D’Aquila, Madeline, Dowal, Sarah, Fox, Meaghan, Gallagher, Jacqueline, Anna Gersten, Rebecca, Hodara, Ariel, Helfand, Ben, Inloes, Jennifer, Kettell, Jennifer, Kuczmarska, Aleksandra, Nee, Jacqueline, Nemeth, Emese, Ochsner, Lisa, Palihnich, Kerry, Parisi, Katelyn, Puelle, Margaret, Rastegar, Sarah, Vella, Margaret, Xu, Guoquan, Bryan, Margaret, Guess, Jamey, Enghorn, Dee, Gross, Alden, Gou, Yun, Habtemariam, Daniel, Isaza, Ilean, Kosar, Cyrus, Rockett, Christopher, Tommet, Douglas, Gruen, Ted, Ross, Meg, Tasker, Katherine, Gee, James, Kolanowski, Ann, Pisani, Margaret, de Rooij, Sophia, Rogers, Selwyn, Studenski, Stephanie, Stern, Yaakov, Whittemore, Anthony, Gottlieb, Gary, Orav, John, and Sperling, Reisa

Published
2019
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37. An Eye-Tracking–Based Dichoptic Home Treatment for Amblyopia

Author

Wygnanski-Jaffe, Tamara, primary, Kushner, Burton J., additional, Moshkovitz, Avital, additional, Belkin, Michael, additional, Yehezkel, Oren, additional, Gan, Ramat, additional, Spierer, Abraham, additional, Wygnanski-Jaffe, Tamara, additional, Zitzer, Nethanel, additional, Cohen, Dan, additional, Shpigelman, Ahuva, additional, Hadash, Maoz, additional, Ortenberg, Ilya, additional, Cohen, Rinat, additional, Leib, Hana, additional, Arow, Majd, additional, Parness, Reut, additional, Rodov, Luba, additional, Goz, Alexandra, additional, Katz, Haia, additional, Bazov, Anabel, additional, Nissen, Chaim, additional, Avraham, Gabriel, additional, Borsha, Emad, additional, Keynann, Idit, additional, Aviv, Tali, additional, Corcos, Nathalie, additional, Roll, Keren, additional, Mezer, Eedy, additional, Brucker, Vered, additional, Abecassis, Meital, additional, Rabinovich, Ronen, additional, Laster, Eran, additional, Politi, Ronit, additional, Givoni, Hila, additional, Amitirat, Ahed, additional, Barrett, Chiya Robert, additional, Zioni, Adelina, additional, Kuperman, Katty, additional, and Crocus, Yael, additional

Published
2023
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48. Contemporary indications for open abdominal aortic aneurysm repair in the endovascular era

Author

Soo Hoo, Andrew J., primary, Fitzgibbon, James J., additional, Hussain, Mohamad A., additional, Scully, Rebecca E., additional, Servais, Andrew B., additional, Nguyen, Louis L., additional, Gravereaux, Edwin C., additional, Semel, Marcus E., additional, Marcaccio, Edward J., additional, Menard, Matthew T., additional, Ozaki, C. Keith, additional, and Belkin, Michael, additional

Published
2022
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50. Looper: An End-to-End ML Platform for Product Decisions

Author

Markov, Igor L., Wang, Hanson, Kasturi, Nitya, Singh, Shaun, Yuen, Sze Wai, Garrard, Mia, Tran, Sarah, Huang, Yin, Wang, Zehui, Glotov, Igor, Gupta, Tanvi, Huang, Boshuang, Chen, Peng, Xie, Xiaowen, Belkin, Michael, Uryasev, Sal, Howie, Sam, Bakshy, Eytan, and Zhou, Norm

Subjects
Software Engineering (cs.SE), FOS: Computer and information sciences, Computer Science - Machine Learning, Computer Science - Software Engineering, Artificial Intelligence (cs.AI), Computer Science - Artificial Intelligence, Machine Learning (cs.LG)
Abstract

Modern software systems and products increasingly rely on machine learning models to make data-driven decisions based on interactions with users, infrastructure and other systems. For broader adoption, this practice must (i) accommodate product engineers without ML backgrounds, (ii) support finegrain product-metric evaluation and (iii) optimize for product goals. To address shortcomings of prior platforms, we introduce general principles for and the architecture of an ML platform, Looper, with simple APIs for decision-making and feedback collection. Looper covers the end-to-end ML lifecycle from collecting training data and model training to deployment and inference, and extends support to personalization, causal evaluation with heterogenous treatment effects, and Bayesian tuning for product goals. During the 2021 production deployment Looper simultaneously hosted 440-1,000 ML models that made 4-6 million real-time decisions per second. We sum up experiences of platform adopters and describe their learning curve., Comment: 11 pages + references, 7 figures; to appear in KDD 2022

Published
2022
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