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276 results on '"Ben Romdhane K"'

7. Choroidal Metastasis as the First Sign of Renal Cell Carcinoma: Case Report

Author

Korbi M, Boughila H, Ben Salem M, L. Baili, Zbiba W, Boussema F, Ben Romdhane K, A. Chebbi, and Rouatbi A

Subjects
Pathology, medicine.medical_specialty, Choroidal metastasis, genetic structures, business.industry, Widespread Disease, Cancer, Fundus (eye), medicine.disease, Primary tumor, eye diseases, Metastasis, medicine.anatomical_structure, Renal cell carcinoma, medicine, sense organs, Choroid, business
Abstract

Metastases to the choroid from renal carcinomas are extremely rare with no more than 10 cases described in the literature. We herein report a case of rare involvement of the eye with choroidal metastasis from renal cell carcinoma presenting as the initial manifestation of an undiagnosed primary tumor. The 32-year-old woman was presented with acute blurring of the vision in the right eye. Fundus examination revealed an amelanotic subretinal mass. Oncology work-up has confirmed the diagnoses of choroidal metastases of renal cell carcinoma with widespread disease and a very poor prognosis.

Published
2017
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8. Une dyspnée fébrile chez un nourrisson de 45 jours

Author

F. Jabnoun, Ben Romdhane K, K. Mrad, Maha Driss, Mourad Hamzaoui, Ibtissem Bellagha, W. Douira-Khomsi, Sondes Sahli, and Hela Louati

Subjects
Pediatrics, medicine.medical_specialty, business.industry, media_common.quotation_subject, Pediatrics, Perinatology and Child Health, Medicine, Girl, business, media_common
Published
2009
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11. Il morbo di Hodgkin primario del nasofaringe: un riscontro raro ma riconosciuto

Author

Ben Romdhane K, M. Maalej, Kochbati L, Imene Abbes, Samia Hannachi Sassi, Karima Mrad, and Jellouli M

Subjects
CD20, Hodgkin s, Pathology, medicine.medical_specialty, CD30, biology, business.industry, Disease, CD15, respiratory system, Virus, Pathology and Forensic Medicine, Serology, stomatognathic diseases, immune system diseases, hemic and lymphatic diseases, otorhinolaryngologic diseases, biology.protein, Immunohistochemistry, Medicine, business
Abstract

We report an uncommon case of Hodgkin's disease confined to the nasopharynx. An isolated polypoid mass of the nasopharynx was observed in a 41-year-old man presenting with increasing bilateral nasal obstruction. Histological study revealed a mixed cellularity type of Hodgkin's disease. Immunohistochemical analysis revealed CD30 and LMP1 expression and a lack of reactivity to CD15, CD3 and CD20. Serological tests excluded recent infection with Epstein-Barr virus. HD of nasopharynx is rare, but has to be recognized as such in view of appropriate treatment.

Published
2002
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13. Immunolocalization of BRCA1 protein in tumor breast tissue: prescreening of BRCA1 mutation in Tunisian patients with hereditary breast cancer?

Author

Troudi W, Uhrhammer N, Ben Romdhane K, Sibille C, Wijden Mahfoudh, Chouchane L, Ben Ayed F, Yj, Bignon, Ben Ammar Elgaaied A, and UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique

Subjects
Male, Cytoplasm, Tunisia, endocrine system diseases, Tunisian population, BRCA1 Protein, Carcinoma, Ductal, Breast, Breast Neoplasms, sequencing, BRCA1, BRCA2, Immunohistochemistry, Breast Neoplasms, Male, Pedigree, breast cancer, lcsh:Biology (General), Receptors, Estrogen, DHPLC, immunohistochemistry, Humans, Female, Tumor Suppressor Protein p53, skin and connective tissue diseases, Receptors, Progesterone, lcsh:QH301-705.5
Abstract

BRCA1 is a tumor suppressor gene which is inactivated by mutation in familial breast and ovarian cancers. Over 300 different disease causing germ-line mutations have been described; 60% are unique to an individual family. This diversity and the large size of the gene lead us to search for a pre-screening method for BRCA1 mutations. Since BRCA1 is a nuclear protein in normal cells, but reported by some authors to be cytoplasmic in breast tumor cells of patients with BRCA1 mutation, we evaluated immunohistochemistry as a prescreening technique to identify BRCA1 mutations in patients with familial presentation of breast cancer. Using a monoclonal antibody against the carboxy-terminal region of BRCA1, we performed immunohistochemistry on 18 tumor samples from patients with hereditary breast cancer. Cytoplasmic staining of BRCA1 was observed in 10 cases. Of the 18 tumors, 12 (66%) showed either BRCA mutation or BRCA1 accumulation or both, indicating that BRCA1 function might be lost in breast tumor cells not only through mutation, but also via abnormal cytoplasmic location. The immunohistochemical test used in this study would not be efficient as a pre-screening method of deleterious mutations, but it appeared useful to investigate tumor physiology.

Published
2007

14. Myofibroblastome mammaire : à propos de trois cas

Author

Sassi, S., primary, Boujelbene, N., additional, Ben Hamida, N., additional, Dhouib, R., additional, Abbes, I., additional, Mrad, K., additional, Driss, M., additional, Doghri, R., additional, Charfi, L., additional, Haouari, H., additional, and Ben Romdhane, K., additional

Published
2013
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17. Complete mutation screening and haplotype characterization of BRCA1 gene in Tunisian patients with familial breast cancer

Author

UCL - MD/MNOP - Département de morphologie normale et pathologique, Troudi, Wafa, Uhrhammer, N., Ben Romdhane, K., Sibille, Catherine, Ben Amor, M., El Khil, H. Khodjet, Jalabert, T., Mahfoudh, W., Chouchane, L., Ben Ayed, F., Bignon, Y. J., Elgaaied, A. Ben Ammar, UCL - MD/MNOP - Département de morphologie normale et pathologique, Troudi, Wafa, Uhrhammer, N., Ben Romdhane, K., Sibille, Catherine, Ben Amor, M., El Khil, H. Khodjet, Jalabert, T., Mahfoudh, W., Chouchane, L., Ben Ayed, F., Bignon, Y. J., and Elgaaied, A. Ben Ammar

Abstract

Breast cancer, the most commonly diagnosed cancer in women, is the second leading cause of cancer death in women worldwide. To investigate the contribution of BRCA1 gene mutations to familial breast cancer in Tunisia, 32 unrelated patients who had at least one first degree relative affected with breast and/or ovarian cancer were analysed. BRCA1 mutation analysis was performed by DNA sequencing of all BRCA1 exons. We identified four different BRCA1 frameshift mutations: c. 4041delAG, c. 2551delG and c. 5266dupC already been described and one novel mutation, c. 211dupA, observed in two unrelated families. C. 5266dupC has previously been found among Jewish Ashkenazi and Eastern European populations. Our study describes it in Arabic/Berber population. Five out of thirty two familial cases had deleterious BRCA1 mutations. Fifteen additional cases carried unclassified variants (UV) or single nucleotide polymorphisms (SNPs). Our study is the first molecular investigation on the role of BRCA1 in hereditary breast cancer in North Tunisia.

Published
2008

18. Immunolocalization of BRCA1 protein in tumor breast tissue: prescreening of BRCA1 mutation in Tunisian patients with hereditary breast cancer?

Author

UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique, Troudi, Wafa, Uhrhammer, N., Ben Romdhane, K., Sibille, Catherine, Mahfoudh, W., Chouchane, L., Ben Ayed, F., Bignon, Y. -J., Elgaaied, A. Ben Ammar, UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique, Troudi, Wafa, Uhrhammer, N., Ben Romdhane, K., Sibille, Catherine, Mahfoudh, W., Chouchane, L., Ben Ayed, F., Bignon, Y. -J., and Elgaaied, A. Ben Ammar

Abstract

BRCA1 is a tumor suppressor gene which is inactivated by mutation in familial breast and ovarian cancers. Over 300 different disease causing germ-line mutations have been described; 60% are unique to an individual family. This diversity and the large size of the gene lead us to search for a pre-screening method for BRCA1 mutations. Since BRCA1 is a nuclear protein in normal cells, but reported by some authors to be cytoplasmic in breast tumor cells of patients with BRCA1 mutation, we evaluated immunohistochemistry as a prescreening technique to identify BRCA1 mutations in patients with familial presentation of breast cancer. Using a monoclonal antibody against the carboxy-terminal region of BRCA1, we performed immunohistochemistry on 18 tumor samples from patients with hereditary breast cancer. Cytoplasmic staining of BRCA1 was observed in 10 cases. Of the 18 tumors, 12 (66%) showed either BRCA mutation or BRCA1 accumulation or both, indicating that BRCA1 function might be lost in breast tumor cells not only through mutation, but also via abnormal cytoplasmic location. The immunohistochemical test used in this study would not be efficient as a pre-screening method of deleterious mutations, but it appeared useful to investigate tumor physiology.

Published
2007

27. Dermatofibrosarcome protubérant de l’enfant

Author

Zaraa, I., primary, Ben abdallah, M., additional, Driss, M., additional, Trojjet, S., additional, Ben Sassi, M., additional, El Euch, D., additional, Mokni, M., additional, Rahal, K., additional, Ben Romdhane, K., additional, and Ben Osman, A., additional

Published
2011
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28. [Struma ovarii: three case reports]

Author

Gamoudi A, Farhat K, Hechiche M, Khattech R, Farouk Benna, Masmoudi M, Rahal K, and Ben Romdhane K

Subjects
Ovarian Neoplasms, Humans, Female, Middle Aged, Struma Ovarii
Published
1994

31. [Conservative treatment of cancer of the breast in Tunisia]

Author

Mesedi W, Farouk Benna, Gamoudi A, Bouaouina N, Sellami D, Rahal K, Ben Youssef R, Ben Romdhane K, Ben Abdallah M, and Maalej M

Subjects
Adult, Survival Rate, Chemotherapy, Adjuvant, Humans, Lymph Node Excision, Breast Neoplasms, Female, Middle Aged, Mastectomy, Segmental, Combined Modality Therapy, Aged, Follow-Up Studies, Neoplasm Staging
Published
1993

39. Métastase orbitaire d’un liposarcome

Author

Hannachi Sassi, S., primary, Braham, E., additional, Bhouri, L., additional, Mrad, K., additional, Abbes, I., additional, Driss, M., additional, Dhouib, R., additional, Jaafoura, H., additional, Bouguila, H., additional, and Ben Romdhane, K., additional

Published
2007
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41. L’histiocytofibrome bénin profond

Author

Hannachi Sassi, S., primary, Trabelsi, M., additional, Abid, L., additional, Mrad, K., additional, Abbess, I., additional, Dhouib, R., additional, Driss, M., additional, Mbarek, M., additional, and Ben Romdhane, K., additional

Published
2006
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