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1. Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data

Author

Charlotte A, V, Ivy R, V, Martijn W, H, Wessel, G, Linda J, S, Caroline J, B, Ben Willem J, M, Christianne Jm, D, Patrick Mm, B, Marjon A, D, Khalil, A, Thilaganathan, B, M Turan, O, Crimmins, S, Harman, C, M Shannon, A, Kumar, S, Dicker, P, Malone, F, C Tully, E, Unterscheider, J, Crippa, I, Ghidini, A, Roncaglia, N, Vergani, P, Bhide, A, D'Antonio, F, Pilu, G, Galindo, A, Herraiz, I, Vázquez-Sarandeses, A, Ebbing, C, L Johnsen, S, O Karlsen, H, Vollgraff Heidweiller-Schreurs, Charlotte A, van Osch, Ivy R, Heymans, Martijn W, Ganzevoort, Wessel, Schoonmade, Linda J, Bax, Caroline J, Mol, Ben Willem J, de Groot, Christianne Jm, Bossuyt, Patrick Mm, de Boer, Marjon A, Asma Khalil, Basky Thilaganathan, Ozhan M Turan, Sarah Crimmins, Chris Harman, Alisson M Shannon, Sailesh Kumar, Patrick Dicker, Fergal Malone, Elizabeth C Tully, Julia Unterscheider, Isabella Crippa, Alessandro Ghidini, Nadia Roncaglia, Patrizia Vergani, Amarnath Bhide, Francesco D'Antonio, Gianluigi Pilu, Alberto Galindo, Ignacio Herraiz, Alicia Vázquez-Sarandeses, Cathrine Ebbing, Synnøve L Johnsen, Henriette O Karlsen, Charlotte A, V, Ivy R, V, Martijn W, H, Wessel, G, Linda J, S, Caroline J, B, Ben Willem J, M, Christianne Jm, D, Patrick Mm, B, Marjon A, D, Khalil, A, Thilaganathan, B, M Turan, O, Crimmins, S, Harman, C, M Shannon, A, Kumar, S, Dicker, P, Malone, F, C Tully, E, Unterscheider, J, Crippa, I, Ghidini, A, Roncaglia, N, Vergani, P, Bhide, A, D'Antonio, F, Pilu, G, Galindo, A, Herraiz, I, Vázquez-Sarandeses, A, Ebbing, C, L Johnsen, S, O Karlsen, H, Vollgraff Heidweiller-Schreurs, Charlotte A, van Osch, Ivy R, Heymans, Martijn W, Ganzevoort, Wessel, Schoonmade, Linda J, Bax, Caroline J, Mol, Ben Willem J, de Groot, Christianne Jm, Bossuyt, Patrick Mm, de Boer, Marjon A, Asma Khalil, Basky Thilaganathan, Ozhan M Turan, Sarah Crimmins, Chris Harman, Alisson M Shannon, Sailesh Kumar, Patrick Dicker, Fergal Malone, Elizabeth C Tully, Julia Unterscheider, Isabella Crippa, Alessandro Ghidini, Nadia Roncaglia, Patrizia Vergani, Amarnath Bhide, Francesco D'Antonio, Gianluigi Pilu, Alberto Galindo, Ignacio Herraiz, Alicia Vázquez-Sarandeses, Cathrine Ebbing, Synnøve L Johnsen, and Henriette O Karlsen

Abstract

Objective: To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone – standard of practice – for adverse perinatal outcome in singleton pregnancies. Design and setting: Meta-analysis based on individual participant data (IPD). Population or sample: Ten centres provided 17 data sets for 21 661 participants, 18 731 of which could be included. Sample sizes per data set ranged from 207 to 9215 individuals. Patient populations varied from uncomplicated to complicated pregnancies. Methods: In a collaborative, pooled analysis, we compared the prognostic value of combining CPR with UA PI, versus UA PI only and CPR only, with a one-stage IPD approach. After multiple imputation of missing values, we used multilevel multivariable logistic regression to develop prediction models. We evaluated the classification performance of all models with receiver operating characteristics analysis. We performed subgroup analyses according to gestational age, birthweight centile and estimated fetal weight centile. Main outcome measures: Composite adverse perinatal outcome, defined as perinatal death, caesarean section for fetal distress or neonatal unit admission. Results: Adverse outcomes occurred in 3423 (18%) participants. The model with UA PI alone resulted in an area under the curve (AUC) of 0.775 (95% CI 0.709–0.828) and with CPR alone in an AUC of 0.778 (95% CI 0.715–0.831). Addition of CPR to the UA PI model resulted in an increase in the AUC of 0.003 points (0.778, 95% CI 0.714–0.831). These results were consistent across all subgroups. Conclusions: Cerebroplacental ratio added no predictive value for adverse perinatal outcome beyond UA PI, when assessing singleton pregnancies, irrespective of gestational age or fetal size. Tweetable abstract: Doppler measurement of cerebroplacental ratio in clinical practice has limited added predictive value to umbilical artery alone.

Published
2021

2. Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data

Author

Vollgraff Heidweiller-Schreurs, Heidweiller-Schreurs, van Osch, Osch, Heymans, Martijn W., Ganzevoort, Wessel, Schoonmade, L.J., Bax, C.J., Mol, Ben W., de Groot, Christianne J.M., Bossuyt, Patrick M.M., de Boer, Boer, Khalil, Asma, Thilaganathan, Basky, Turan, Ozhan M, Crimmins, Sarah, Harman, Chris, Shannon, Alisson M, Kumar, Sailesh, Dicker, Patrick, Malone, Fergal, Tully, Elizabeth C, Unterscheider, Julia, Crippa, Isabella, Ghidini, Alessandro, Roncaglia, Nadia, Vergani, Patrizia, Bhide, Amar, D'Antonio, Francesco, Pilu, Gianluigi, Galindo, Alberto, Herraiz, Ignacio, Vázquez-Sarandeses, Alicia, Ebbing, Cathrine, Johnsen, Synnøve Lian, Karlsen, Henriette Odland, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), Epidemiology and Data Science, APH - Personalized Medicine, APH - Methodology, Charlotte A, V, Ivy R, V, Martijn W, H, Wessel, G, Linda J, S, Caroline J, B, Ben Willem J, M, Christianne Jm, D, Patrick Mm, B, Marjon A, D, Khalil, A, Thilaganathan, B, M Turan, O, Crimmins, S, Harman, C, M Shannon, A, Kumar, S, Dicker, P, Malone, F, C Tully, E, Unterscheider, J, Crippa, I, Ghidini, A, Roncaglia, N, Vergani, P, Bhide, A, D'Antonio, F, Pilu, G, Galindo, A, Herraiz, I, Vázquez-Sarandeses, A, Ebbing, C, L Johnsen, S, O Karlsen, H, Obstetrics and Gynaecology, ARD - Amsterdam Reproduction and Development, APH - Digital Health, APH - Quality of Care, Vollgraff Heidweiller-Schreurs C.A., van Osch I.R., Heymans M.W., Ganzevoort W., Schoonmade L.J., Bax C.J., Mol B.W.J., de Groot C.J.M., Bossuyt P.M.M., de Boer M.A., Khalil A., Thilaganathan B., Turan O.M., Crimmins S., Harman C., Shannon A.M., Kumar S., Dicker P., Malone F., Tully E.C., Unterscheider J., Crippa I., Ghidini A., Roncaglia N., Vergani P., Bhide A., D'Antonio F., Pilu G., Galindo A., Herraiz I., Vazquez-Sarandeses A., Ebbing C., Johnsen S.L., and Karlsen H.O.

Subjects
medicine.medical_specialty, medicine.medical_treatment, Population, Cerebroplacental ratio, Logistic regression, Ultrasonography, Prenatal, Umbilical Arteries, meta-analysi, fetal growth restriction, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Pregnancy, medicine, Fetal distress, Humans, Caesarean section, education, education.field_of_study, middle cerebral artery, 030219 obstetrics & reproductive medicine, prognostic accuracy, Receiver operating characteristic, Obstetrics, business.industry, Doppler, Obstetrics and Gynecology, Gestational age, Ultrasonography, Doppler, individual participant data, medicine.disease, meta-analysis, Pregnancy Complications, Sample size determination, Meta-analysis, Pulsatile Flow, Female, business
Abstract

Objective: To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone–standard of practice–for adverse perinatal outcome in singleton pregnancies. Design and setting: Meta-analysis based on individual participant data (IPD). Population or sample: Ten centres provided 17 data sets for 21661 participants, 18731 of which could be included. Sample sizes per data set ranged from 207 to 9215 individuals. Patient populations varied from uncomplicated to complicated pregnancies. Methods: In a collaborative, pooled analysis, we compared the prognostic value of combining CPR with UA PI, versus UA PI only and CPR only, with a one-stage IPD approach. After multiple imputation of missing values, we used multilevel multivariable logistic regression to develop prediction models. We evaluated the classification performance of all models with receiver operating characteristics analysis. We performed subgroup analyses according to gestational age, birthweight centile and estimated fetal weight centile. Main outcome measures: Composite adverse perinatal outcome, defined as perinatal death, caesarean section for fetal distress or neonatal unit admission. Results: Adverse outcomes occurred in 3423 (18%) participants. The model with UA PI alone resulted in an area under the curve (AUC) of 0.775 (95% CI 0.709–0.828) and with CPR alone in an AUC of 0.778 (95% CI 0.715–0.831). Addition of CPR to the UA PI model resulted in an increase in the AUC of 0.003 points (0.778, 95% CI 0.714–0.831). These results were consistent across all subgroups. Conclusions: Cerebroplacental ratio added no predictive value for adverse perinatal outcome beyond UA PI, when assessing singleton pregnancies, irrespective of gestational age or fetal size. Tweetable abstract: Doppler measurement of cerebroplacental ratio in clinical practice has limited added predictive value to umbilical artery alone.

Published
2021
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