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1. Postmortem Interval and Diagnostic Performance of the Autopsy Methods

Author

Hurtado, Juan Carlos, Quintó, Llorenç, Castillo, Paola, Carrilho, Carla, Fernandes, Fabiola, Jordao, Dercio, Lovane, Lucilia, Navarro, Mireia, Casas, Isaac, Bene, Rosa, Nhampossa, Tacilta, Santos Ritchie, Paula, Bandeira, Sónia, Sambo, Calvino, Chicamba, Valeria, Mocumbi, Sibone, Jaze, Zara, Mabota, Flora, Ismail, Mamudo R., Lorenzoni, Cesaltina, Guisseve, Assucena, Rakislova, Natalia, Marimon, Lorena, Castrejon, Natalia, Sanz, Ariadna, Cossa, Anelsio, Mandomando, Inacio, Munguambe, Khátia, Maixenchs, Maria, Muñoz-Almagro, Carmen, Macete, Eusebio, Alonso, Pedro, Vila, Jordi, Bassat, Quique, Menéndez, Clara, Martínez, Miguel J., and Ordi, Jaume

Published
2018
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2. Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings

Author

Letang, Emilio, primary, Rakislova, Natalia, additional, Martinez, Miguel J, additional, Carlos Hurtado, Juan, additional, Carrilho, Carla, additional, Bene, Rosa, additional, Mandomando, Inacio, additional, Quintó, Llorenç, additional, Nhampossa, Tacilta, additional, Chicamba, Valéria, additional, Luis, Elvira, additional, Ismail, Mamudo R, additional, Fernandes, Fabiola, additional, Lorenzoni, Cesaltina, additional, Ferreira, Luiz, additional, Freire, Monique, additional, Teresa Rodrigo-Calvo, Maria, additional, Guerrero, José, additional, Munguambe, Khátia, additional, Maixenchs, Maria, additional, Navarro, Mireia, additional, Casas, Isaac, additional, Marimon, Lorena, additional, Ferrando, Melania, additional, Macete, Eusebio, additional, Lacerda, Marcus, additional, Bassat, Quique, additional, Menéndez, Clara, additional, and Ordi, Jaume, additional

Published
2021
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3. Validity of a Minimally Invasive Autopsy for Cause of Death Determination in Adults in Mozambique: An Observational Study

Author

Castillo, Paola, Martínez, Miguel J., Ussene, Esperança, Jordao, Dercio, Lovane, Lucilia, Ismail, Mamudo R., Carrilho, Carla, Lorenzoni, Cesaltina, Fernandes, Fabiola, Bene, Rosa, Palhares, Antonio, Ferreira, Luiz, Lacerda, Marcus, Mandomando, Inacio, Vila, Jordi, Hurtado, Juan Carlos, Munguambe, Khátia, Maixenchs, Maria, Sanz, Ariadna, Quintó, Llorenç, Macete, Eusebio, Alonso, Pedro, Bassat, Quique, Menéndez, Clara, and Ordi, Jaume

Subjects
Death -- Causes of -- Research -- Investigations, Autopsy -- Methods -- Comparative analysis, Adults -- Health aspects -- Death of, Company legal issue, Biological sciences
Abstract

Background There is an urgent need to identify tools able to provide reliable information on the cause of death in low-income regions, since current methods (verbal autopsy, clinical records, and complete autopsies) are either inaccurate, not feasible, or poorly accepted. We aimed to compare the performance of a standardized minimally invasive autopsy (MIA) approach with that of the gold standard, the complete diagnostic autopsy (CDA), in a series of adults who died at Maputo Central Hospital in Mozambique. Methods and Findings In this observational study, coupled MIAs and CDAs were performed in 112 deceased patients. The MIA analyses were done blindly, without knowledge of the clinical data or the results of the CDA. We compared the MIA diagnosis with the CDA diagnosis of cause of death. CDA diagnoses comprised infectious diseases (80; 71.4%), malignant tumors (16; 14.3%), and other diseases, including non-infectious cardiovascular, gastrointestinal, kidney, and lung diseases (16; 14.3%). A MIA diagnosis was obtained in 100/112 (89.2%) cases. The overall concordance between the MIA diagnosis and CDA diagnosis was 75.9% (85/112). The concordance was higher for infectious diseases and malignant tumors (63/80 [78.8%] and 13/16 [81.3%], respectively) than for other diseases (9/16; 56.2%). The specific microorganisms causing death were identified in the MIA in 62/74 (83.8%) of the infectious disease deaths with a recognized cause. The main limitation of the analysis is that both the MIA and the CDA include some degree of expert subjective interpretation. Conclusions A simple MIA procedure can identify the cause of death in many adult deaths in Mozambique. This tool could have a major role in improving the understanding and surveillance of causes of death in areas where infectious diseases are a common cause of mortality., Author(s): Paola Castillo 1, Miguel J. Martínez 1,2, Esperança Ussene 3,4, Dercio Jordao 3,4, Lucilia Lovane 3,4, Mamudo R. Ismail 3,4, Carla Carrilho 3,4, Cesaltina Lorenzoni 3,4, Fabiola Fernandes 3,4, [...]

Published
2016
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4. Contribution of the clinical information to the accuracy of the minimally invasive and the complete diagnostic autopsy☆☆☆

Author

Fernandes, Fabiola, Castillo, Paola, Bassat Orellana, Quique, Quintó, Llorenç, Hurtado, Juan Carlos, Martínez Yoldi, Miguel Julián, Lovane, Lucilia, Jordao, Dercio, Bene, Rosa, Nhampossa, Tacilta, Ritchie, Paula Santos, Bandeira, Sónia, Sambo, Calvino, Chicamba, Valeria, Mocumbi, Sibone, Jaze, Zara, Mabota, Flora, Ismail, Mamudo Rafik, Lorenzoni, Cesaltina, Sanz, Ariadna, Rakislova, Natalia, Marimon, Lorena, Cossa, Anelsio, Mandomando, Inácio, Vila Estapé, Jordi, Maixenchs, Maria, Munguambe, Khátia, Macete, Eusebio Víctor, Alonso, Pedro, Menéndez, Clara, Ordi i Majà, Jaume, and Carrilho, Carla

Subjects
Adult, Male, Adolescent, Infant, Newborn, Infant, Middle Aged, Article, Death, Young Adult, Diagnòstic, Child, Preschool, Diagnosis, Humans, Autòpsia, Female, Autopsy, Child, Aged
Abstract

Although autopsy diagnosis includes routinely, a thorough evaluation of all available pathological results and also of any available clinical data, the contribution of this clinical information to the diagnostic yield of the autopsy has not been analyzed. We aimed to determine to which degree the use of clinical data improves the diagnostic accuracy of the complete diagnostic autopsy (CDA) and the minimally invasive autopsy (MIA), a simplified pathological postmortem procedure designed for low-income sites. 264 coupled MIA and CDA procedures (112 adults, 57 maternal deaths, 54 children and 41 neonates) were performed at the Maputo hospital, Mozambique. We compared the diagnoses obtained by the MIA blind to clinical data (MIAb), the MIA adding the clinical information (MIAc), and the CDA blind to clinical information (CDAb), with the results of the gold standard, the CDA with clinical data, by comparing the ICD-10 codes and the main diagnostic classes obtained with each evaluation strategy (MIAb, MIAc, CDAb, CDAc). The clinical data increased diagnostic coincidence to the MIAb with the gold standard in 30/264 (11%) cases and modified the CDAb diagnosis in 20/264 (8%) cases. The increase in concordance between MIAb and MIAc with the gold standard was significant in neonatal deaths (kappa increasing from 0.404 to 0.618, P=.0271), adult deaths (kappa increasing from 0.732 to 0.813, P=.0221) and maternal deaths (kappa increasing from 0.485 to 0.836, P

Published
2019

5. Clinico-pathological discrepancies in the diagnosis of causes of death in adults in Mozambique: A retrospective observational study

Author

Ordi, Jaume, primary, Castillo, Paola, additional, Garcia-Basteiro, Alberto L., additional, Moraleda, Cinta, additional, Fernandes, Fabiola, additional, Quintó, Llorenç, additional, Hurtado, Juan Carlos, additional, Letang, Emili, additional, Lovane, Lucilia, additional, Jordao, Dercio, additional, Navarro, Mireia, additional, Bene, Rosa, additional, Nhampossa, Tacilta, additional, Ismail, Mamudo R., additional, Lorenzoni, Cesaltina, additional, Guisseve, Assucena, additional, Rakislova, Natalia, additional, Varo, Rosauro, additional, Marimon, Lorena, additional, Sanz, Ariadna, additional, Cossa, Anelsio, additional, Mandomando, Inacio, additional, Maixenchs, Maria, additional, Munguambe, Khátia, additional, Vila, Jordi, additional, Macete, Eusebio, additional, Alonso, Pedro L., additional, Bassat, Quique, additional, Martínez, Miguel J., additional, Carrilho, Carla, additional, and Menéndez, Clara, additional

Published
2019
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6. Contribution of the clinical information to the accuracy of the minimally invasive and the complete diagnostic autopsy

Author

Fernandes, Fabiola, primary, Castillo, Paola, additional, Bassat, Quique, additional, Quintó, Llorenç, additional, Hurtado, Juan Carlos, additional, Martínez, Miguel J., additional, Lovane, Lucilia, additional, Jordao, Dercio, additional, Bene, Rosa, additional, Nhampossa, Tacilta, additional, Ritchie, Paula Santos, additional, Bandeira, Sónia, additional, Sambo, Calvino, additional, Chicamba, Valeria, additional, Mocumbi, Sibone, additional, Jaze, Zara, additional, Mabota, Flora, additional, Ismail, Mamudo R., additional, Lorenzoni, Cesaltina, additional, Sanz, Ariadna, additional, Rakislova, Natalia, additional, Marimon, Lorena, additional, Cossa, Anelsio, additional, Mandomando, Inacio, additional, Vila, Jordi, additional, Maixenchs, Maria, additional, Munguambe, Khátia, additional, Macete, Eusebio, additional, Alonso, Pedro, additional, Menéndez, Clara, additional, Ordi, Jaume, additional, and Carrilho, Carla, additional

Published
2019
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7. A prospective observational study of bacteraemia in adults admitted to an urban Mozambican hospital

Author

Preziosi, Michael, primary, Zimba, Tomas Francisco, additional, Lee, Kristen, additional, Tomas, Manuel, additional, Kinlin, Suraida, additional, Nhatave-Paiva, Clotilde, additional, Bene, Rosa, additional, Paunde, Tania, additional, Lopes, Helder, additional, Kalkhoff, Stephen, additional, Prathap, Vishnu, additional, Akrami, Kevan, additional, Noormahomed, Emilia Virginia, additional, Schooley, Robert Turner, additional, and Aronoff-Spencer, Eliah, additional

Published
2015
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