1. Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins
- Author
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Stella Cascioferro, Maria Valeria Raimondi, Maria Grazia Cusimano, Demetrio Raffa, Benedetta Maggio, Giuseppe Daidone, and Domenico Schillaci
- Subjects
pyrrolomycins ,antibiotic resistance ,antibiofilm agents ,pyoluteorin ,pentabromopseudilin ,Organic chemistry ,QD241-441 - Abstract
The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis.
- Published
- 2015
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