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179 results on '"Benedito, Rui"'

1. Incongruence between transcriptional and vascular pathophysiological cell states

Author

Fernández-Chacón, Macarena, Mühleder, Severin, Regano, Alvaro, Garcia-Ortega, Lourdes, Rocha, Susana F., Torroja, Carlos, Sanchez-Muñoz, Maria S., Lytvyn, Mariya, Casquero-Garcia, Verónica, De Andrés-Laguillo, Macarena, Muhl, Lars, Orlich, Michael M., Gaengel, Konstantin, Camafeita, Emilio, Vázquez, Jesús, Benguría, Alberto, Iruela-Arispe, M. Luisa, Dopazo, Ana, Sánchez-Cabo, Fátima, Carter, Hannah, and Benedito, Rui

Published
2023
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4. iSuRe-HadCre is an essential tool for effective conditional genetics

Author

Garcia-Gonzalez, Irene, primary, Rocha, Susana F, additional, Hamidi, Anahita, additional, Garcia-Ortega, Lourdes, additional, Regano, Alvaro, additional, Sanchez-Muñoz, Maria S, additional, Lytvyn, Mariya, additional, Garcia-Cabero, Aroa, additional, Roig-Soucase, Sergi, additional, Schoofs, Hans, additional, Castro, Marco, additional, Sabata, Helena, additional, Potente, Michael, additional, Graupera, Mariona, additional, Makinen, Taija, additional, and Benedito, Rui, additional

Published
2024
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5. Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Author

Bernier-Latmani, Jeremiah, Cisarovsky, Christophe, Mahfoud, Samantha, Ragusa, Simone, Dupanloup, Isabelle, Barras, David, Renevey, François, Nassiri, Sina, Anderle, Pascale, Squadrito, Mario Leonardo, Siegert, Stefanie, Davanture, Suzel, González-Loyola, Alejandra, Fournier, Nadine, Luther, Sanjiv A., Benedito, Rui, Valet, Philippe, Zhou, Bin, De Palma, Michele, Delorenzi, Mauro, Sempoux, Christine, and Petrova, Tatiana V.

Published
2022
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6. Angiocrine polyamine production regulates adiposity

Author

Monelli, Erika, Villacampa, Pilar, Zabala-Letona, Amaia, Martinez-Romero, Anabel, Llena, Judith, Beiroa, Daniel, Gouveia, Leonor, Chivite, Iñigo, Zagmutt, Sebastián, Gama-Perez, Pau, Osorio-Conles, Oscar, Muixi, Laia, Martinez-Gonzalez, Ainara, Castillo, Sandra D., Martín-Martín, Natalia, Castel, Pau, Valcarcel-Jimenez, Lorea, Garcia-Gonzalez, Irene, Villena, Josep A., Fernandez-Ruiz, Sonia, Serra, Dolors, Herrero, Laura, Benedito, Rui, Garcia-Roves, Pablo, Vidal, Josep, Cohen, Paul, Nogueiras, Rubén, Claret, Marc, Carracedo, Arkaitz, and Graupera, Mariona

Published
2022
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12. Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption

Author

Zarkada, Georgia, primary, Chen, Xun, additional, Zhou, Xuetong, additional, Lange, Martin, additional, Zeng, Lei, additional, Lv, Wenyu, additional, Zhang, Xuan, additional, Li, Yunhua, additional, Zhou, Weibin, additional, Liu, Keli, additional, Chen, Dongying, additional, Ricard, Nicolas, additional, Liao, James, additional, Kim, Young-Bum, additional, Benedito, Rui, additional, Claesson-Welsh, Lena, additional, Alitalo, Kari, additional, Simons, Michael, additional, Ju, Rong, additional, Li, Xuri, additional, Eichmann, Anne, additional, and Zhang, Feng, additional

Published
2023
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14. iFlpMosaics: A method for the ratiometric induction and high-throughput comparative analysis of mutant and wildtype cells

Author

Garcia-Gonzalez, Irene, primary, Gambera, Stefano, additional, Regano, Alvaro, additional, Rocha, Susana F, additional, Garcia-Ortega, Lourdes, additional, Lytvyn, Mariya, additional, Sanchez-Munoz, Maria S., additional, Garcia-Cabero, Aroa, additional, Zagorac, Ivana, additional, Luo, Wen, additional, Fernandez-Chacon, Macarena, additional, Casquero-Garcia, Veronica, additional, Lunella, Federica Francesca, additional, and Benedito, Rui, additional

Published
2023
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15. Radical fringe facilitates NOTCH1 and JAG1cisinteractions to sustain Hematopoietic stem cell fate

Author

Thambyrajah, Roshana, primary, Maqueda, Maria, additional, Neo, Wen Hao, additional, Imbach, Kathleen, additional, Guillen, Yolanda, additional, Grases, Daniela, additional, Fadlullah, Zaki, additional, Gambera, Stefano, additional, Matteini, Francesca, additional, Wang, Xiaonan, additional, Calero-Nieto, Fernando J., additional, Esteller, Manel, additional, Florian, Maria Carolina, additional, Porta, Eduard, additional, Benedito, Rui, additional, Göttgens, Berthold, additional, Lacaud, Georges, additional, Espinosa, Lluis, additional, and Bigas, Anna, additional

Published
2023
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16. Incongruence between transcriptional and vascular pathophysiological cell states

Author

Fernandez-Chacon, Macarena, primary, Muhleder, Severin, additional, Regano, Alvaro, additional, Garcia-Ortega, Lourdes, additional, Torroja, Carlos, additional, Lytvyn, Mariya, additional, Sanchez-Munoz, Maria S, additional, Casquero-Garcia, Veronica, additional, Camafeita, Emilio, additional, Vazquez, Jesus, additional, Benguria, Alberto, additional, Dopazo, Ana, additional, Sanchez-Cabo, Fatima, additional, Carter, Hannah, additional, and Benedito, Rui, additional

Published
2023
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23. DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport

Author

Bernier-Latmani, Jeremiah, Cisarovsky, Christophe, Demir, Cansaran Saygili, Bruand, Marine, Jaquet, Muriel, Davanture, Suzel, Ragusa, Simone, Siegert, Stefanie, Dormond, Olivier, Benedito, Rui, Radtke, Freddy, Luther, Sanjiv A., and Petrova, Tatiana V.

Subjects
Biological transport -- Genetic aspects, Lymphatics -- Medical examination, Regeneration (Biology) -- Genetic aspects, Health care industry
Abstract

The small Intestine Is a dynamic and complex organ that Is characterized by constant epithelium turnover and crosstalk among various cell types and the microbiota. Lymphatic capillaries of the small intestine, called lacteals, play key roles in dietary fat absorption and the gut immune response; however, little is known about the molecular regulation of lacteal function. Here, we performed a high-resolution analysis of the small intestinal stroma and determined that lacteals reside in a permanent regenerative, proliferative state that is distinct from embryonic lymphangiogenesis or quiescent lymphatic vessels observed in other tissues. We further demonstrated that this continuous regeneration process is mediated by Notch signaling and that the expression of the Notch ligand delta-like 4 (DLL4) in lacteals requires activation of VEGFR3 and VEGFR2. Moreover, genetic inactivation of Dll4 in lymphatic endothelial cells led to lacteal regression and impaired dietary fat uptake. We propose that such a slow lymphatic regeneration mode is necessary to match a unique need of intestinal lymphatic vessels for both continuous maintenance, due to the constant exposure to dietary fat and mechanical strain, and efficient uptake of fat and immune cells. Our work reveals how lymphatic vessel responses are shaped by tissue specialization and uncover a role for continuous DLL4 signaling in the function of adult lymphatic vasculature., Introduction The small intestinal epithelium provides a barrier between the microorganism-rich intestinal lumen and the underlying stroma. Epithelial cells are constantly renewed from the stem cell niche at the crypt [...]

Published
2015
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24. Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology

Author

Mühleder, Severin, Fernández-Chacón, Macarena, Garcia-Gonzalez, Irene, Benedito, Rui, FWF Austrian Science Fund, Fundación La Caixa, European Research Council, Centro Nacional de Investigaciones Cardiovasculares Carlos III (España), Ministerio de Economía, Industria y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), and Fundación ProCNIC

Subjects
Senescence, Aging, Cell cycle checkpoint, Vascular differentiation, Angiogenesis, Endothelial cells, medicine.medical_treatment, Neovascularization, Physiologic, Review, Disease, Biology, Cell-cycle arrest, Regenerative medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Cell Movement, Neoplasms, medicine, Humans, Molecular Biology, Cell Proliferation, 030304 developmental biology, Feedback, Physiological, Pharmacology, 0303 health sciences, Neovascularization, Pathologic, Cell growth, Growth factor, Endothelial Cells, Cell Biology, Cell biology, Cardiovascular Diseases, 030220 oncology & carcinogenesis, Malformations, Molecular Medicine, Signal transduction, Sprouting, Signal Transduction
Abstract

Therapeutic modulation of vascular cell proliferation and migration is essential for the effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The general view is that an increase in vascular growth factor levels or mitogenic stimulation is beneficial for angiogenesis, since it leads to an increase in both endothelial proliferation and sprouting. However, several recent studies showed that an increase in mitogenic stimuli can also lead to the arrest of angiogenesis. This is due to the existence of intrinsic signaling feedback loops and cell cycle checkpoints that work in synchrony to maintain a balance between endothelial proliferation and sprouting. This balance is tightly and effectively regulated during tissue growth and is often deregulated or impaired in disease. Most therapeutic strategies used so far to promote vascular growth simply increase mitogenic stimuli, without taking into account its deleterious effects on this balance and on vascular cells. Here, we review the main findings on the mechanisms controlling physiological vascular sprouting, proliferation, and senescence and how those mechanisms are often deregulated in acquired or congenital cardiovascular disease leading to a diverse range of pathologies. We also discuss alternative approaches to increase the effectiveness of pro-angiogenic therapies in cardiovascular regenerative medicine. Severin Mühleder was funded by the Austrian Science Fund (FWF) project J4358. Macarena Fernández-Chacón and Irene Garcia-Gonzalez were supported by PhD fellowships from Fundación La Caixa (CX_E-2015-01 and CX-SO-16-1, respectively). Rui Benedito was funded by the European Research Council (ERC-2014-StG—638028), the Centro Nacional de Investigaciones Cardiovasculares (CNIC), and by the Ministerio de Economia, Industria y Competitividad (MEIC: SAF2013-44329-P, SAF2017-89299-P, and RYC-2013-13209). The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades (MCNU) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Sí

Published
2020

28. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

Author

Benedito, Rui, Rocha, Susana F., Woeste, Marina, Zamykal, Martin, Radtke, Freddy, Casanovas, Oriol, Duarte, Antonio, Pytowski, Bronislaw, and Adams, Ralf H.

Subjects
Neovascularization -- Research, Endothelium -- Research, Vascular endothelial growth factor -- Physiological aspects, Growth factor receptors -- Physiological aspects, Cellular control mechanisms -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Developing tissues and growing tumours produce vascular endothelial growth factors (VEGFs), leading to the activation of the corresponding receptors in endothelial cells. The resultant angiogenic expansion of the local vasculature [...]

Published
2012
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30. Notch Enhances the Endothelial Inflammatory Response: WS1.4

Author

Sundlisæter, Eirik, Edelmann, Reidunn Jetne, Hol, Johanna, Krüger, Stig, Wang, Junbai, Kasprzycka, Monika, Bækkevold, Espen, Donaldson, Ian, Scott, Helge, Ehling, Manuel, Adams, Ralf H., Siebel, Christian W., Benedito, Rui, and Haraldsen, Guttorm

Published
2014

31. The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

Author

Benedito, Rui, Roca, Cristina, Sorensen, Inga, Adams, Susanne, Gossler, Achim, Fruttiger, Marcus, and Adams, Ralf H.

Subjects
Cancer -- Research, Universities and colleges, Neovascularization, Transferases, Oncology, Experimental, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2009.03.025 Byline: Rui Benedito (1)(2), Cristina Roca (1), Inga Sorensen (3), Susanne Adams (1)(2), Achim Gossler (3), Marcus Fruttiger (4), Ralf H. Adams (1)(2) Keywords: DEVBIO; SIGNALING; CELLBIO Abstract: The Notch pathway is a highly conserved signaling system that controls a diversity of growth, differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is activated by binding of the Notch receptor to its ligand Delta-like 4 (Dll4). Here, we show that the Notch ligand Jagged1 is a potent proangiogenic regulator in mice that antagonizes Dll4-Notch signaling in cells expressing Fringe family glycosyltransferases. Upon glycosylation of Notch, Dll4-Notch signaling is enhanced, whereas Jagged1 has weak signaling capacity and competes with Dll4. Our findings establish that the equilibrium between two Notch ligands with distinct spatial expression patterns and opposing functional roles regulates angiogenesis, a mechanism that might also apply to other Notch-controlled biological processes. Author Affiliation: (1) Cancer Research UK London Research Institute, Vascular Development Laboratory, London WC2A 3PX, UK (2) Max Planck Institute for Molecular Biomedicine, Department Tissue Morphogenesis and University of Munster, Faculty of Medicine, Munster 48149, Germany (3) Institute for Molecular Biology OE5250, Medizinische Hochschule Hannover, Hannover D-30625, Germany (4) Institute of Ophthalmology, University College London, London EC1V 9EL, UK Article History: Received 21 August 2008; Revised 22 December 2008; Accepted 16 March 2009 Article Note: (miscellaneous) Published: June 11, 2009

Published
2009

32. Arterialization requires the timely suppression of cell growth

Author

Luo, Wen, primary, Garcia-Gonzalez, Irene, additional, Fernández-Chacón, Macarena, additional, Casquero-Garcia, Verónica, additional, Sanchez-Muñoz, Maria S., additional, Mühleder, Severin, additional, Garcia-Ortega, Lourdes, additional, Andrade, Jorge, additional, Potente, Michael, additional, and Benedito, Rui, additional

Published
2020
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33. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

Author

Crespo, María, primary, Gonzalez-Teran, Barbara, additional, Nikolic, Ivana, additional, Mora, Alfonso, additional, Folgueira, Cintia, additional, Rodríguez, Elena, additional, Leiva-Vega, Luis, additional, Pintor-Chocano, Aránzazu, additional, Fernández-Chacón, Macarena, additional, Ruiz-Garrido, Irene, additional, Cicuéndez, Beatriz, additional, Tomás-Loba, Antonia, additional, A-Gonzalez, Noelia, additional, Caballero-Molano, Ainoa, additional, Beiroa, Daniel, additional, Hernández-Cosido, Lourdes, additional, Torres, Jorge L, additional, Kennedy, Norman J, additional, Davis, Roger J, additional, Benedito, Rui, additional, Marcos, Miguel, additional, Nogueiras, Ruben, additional, Hidalgo, Andrés, additional, Matesanz, Nuria, additional, Leiva, Magdalena, additional, and Sabio, Guadalupe, additional

Published
2020
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34. Author response: Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

Author

Crespo, María, primary, Gonzalez-Teran, Barbara, additional, Nikolic, Ivana, additional, Mora, Alfonso, additional, Folgueira, Cintia, additional, Rodríguez, Elena, additional, Leiva-Vega, Luis, additional, Pintor-Chocano, Aránzazu, additional, Fernández-Chacón, Macarena, additional, Ruiz-Garrido, Irene, additional, Cicuéndez, Beatriz, additional, Tomás-Loba, Antonia, additional, A-Gonzalez, Noelia, additional, Caballero-Molano, Ainoa, additional, Beiroa, Daniel, additional, Hernández-Cosido, Lourdes, additional, Torres, Jorge L, additional, Kennedy, Norman J, additional, Davis, Roger J, additional, Benedito, Rui, additional, Marcos, Miguel, additional, Nogueiras, Ruben, additional, Hidalgo, Andrés, additional, Matesanz, Nuria, additional, Leiva, Magdalena, additional, and Sabio, Guadalupe, additional

Published
2020
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37. Dosage-sensitive requirement for mouse D114 in artery development

Author

Duarte, Antonio, Bekman, Evguenia, Shutter, John R., Costa, Luis, Benedito, Rui, Henrique, Domingos, Trindade, Alexandre, Rossant, Janet, Diniz, Patricia, and Hirashima, Masanori

Subjects
Autocrine mechanisms -- Research, Molecular biology -- Research, Ligands (Biochemistry) -- Research, Gene mutations -- Research, Biological sciences
Abstract

Involvement of the Notch pathway in vascular devolvement is demonstrated by both gain -and loss-of-function mutations in humans, mice, and zebrafish. The Delta-like 4 (D114) ligand alone is required in a dossage-sensitive manner for normal arterial patterning in development, which implicates D114 as the specific mammalian endothelial for autocrine endothelial Notch signaling.

Published
2004

41. Negative Regulators of Vessel Patterning

Author

Suchting, Steven, primary, Freitas, Catarina, additional, le Noble, Ferdinand, additional, Benedito, Rui, additional, Bréant, Christiane, additional, Duarte, Antonio, additional, and Eichmann, Anne, additional

Published
2007
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42. Transitions in cell potency during early mouse development are driven by Notch

Author

Menchero, Sergio, primary, Rollan, Isabel, additional, Lopez-Izquierdo, Antonio, additional, Andreu, Maria Jose, additional, Sainz de Aja, Julio, additional, Kang, Minjung, additional, Adan, Javier, additional, Benedito, Rui, additional, Rayon, Teresa, additional, Hadjantonakis, Anna-Katerina, additional, and Manzanares, Miguel, additional

Published
2019
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44. Transitions in cell potency during early mouse development are driven by Notch

Author

Menchero, Sergio, primary, Lopez-Izquierdo, Antonio, additional, Rollan, Isabel, additional, Sainz de Aja, Julio, additional, Andreu, Maria Jose, additional, Kang, Minjung, additional, Adan, Javier, additional, Benedito, Rui, additional, Rayon, Teresa, additional, Hadjantonakis, Anna-Katerina, additional, and Manzanares, Miguel, additional

Published
2018
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45. Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers

Author

Poulsen, Lars la Cour, primary, Edelmann, Reidunn Jetne, additional, Krüger, Stig, additional, Diéguez-Hurtado, Rodrigo, additional, Shah, Akshay, additional, Stav-Noraas, Tor Espen, additional, Renzi, Anastasia, additional, Szymanska, Monika, additional, Wang, Junbai, additional, Ehling, Manuel, additional, Benedito, Rui, additional, Kasprzycka, Monika, additional, Bækkevold, Espen, additional, Sundnes, Olav, additional, Midwood, Kim S., additional, Scott, Helge, additional, Collas, Philippe, additional, Siebel, Christian W., additional, Adams, Ralf H., additional, Haraldsen, Guttorm, additional, Sundlisæter, Eirik, additional, and Hol, Johanna, additional

Published
2018
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46. Dual ifgMosaic: A Versatile Method for Multispectral and Combinatorial Mosaic Gene-Function Analysis

Author

Pontes-Quero, Samuel, primary, Heredia, Luis, additional, Casquero-García, Verónica, additional, Fernández-Chacón, Macarena, additional, Luo, Wen, additional, Hermoso, Ana, additional, Bansal, Mayank, additional, Garcia-Gonzalez, Irene, additional, Sanchez-Muñoz, Maria S., additional, Perea, Juan R., additional, Galiana-Simal, Adrian, additional, Rodriguez-Arabaolaza, Iker, additional, Del Olmo-Cabrera, Sergio, additional, Rocha, Susana F., additional, Criado-Rodriguez, Luis M., additional, Giovinazzo, Giovanna, additional, and Benedito, Rui, additional

Published
2017
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47. Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception

Author

Bicker, Frank, primary, Vasic, Verica, additional, Horta, Guilherme, additional, Ortega, Felipe, additional, Nolte, Hendrik, additional, Kavyanifar, Atria, additional, Keller, Stefanie, additional, Stankovic, Nevenka Dudvarski, additional, Harter, Patrick N., additional, Benedito, Rui, additional, Lutz, Beat, additional, Bäuerle, Tobias, additional, Hartwig, Jens, additional, Baumgart, Jan, additional, Krüger, Marcus, additional, Radyushkin, Konstantin, additional, Alberi, Lavinia, additional, Berninger, Benedikt, additional, and Schmidt, Mirko H. H., additional

Published
2017
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48. Sequential Notch activation regulates ventricular chamber development

Author

D’Amato, Gaetano, primary, Luxán, Guillermo, additional, del Monte-Nieto, Gonzalo, additional, Martínez-Poveda, Beatriz, additional, Torroja, Carlos, additional, Walter, Wencke, additional, Bochter, Matthew S., additional, Benedito, Rui, additional, Cole, Susan, additional, Martinez, Fernando, additional, Hadjantonakis, Anna-Katerina, additional, Uemura, Akiyoshi, additional, Jiménez-Borreguero, Luis J., additional, and de la Pompa, José Luis, additional

Published
2015
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49. Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers.

Author

la Cour Poulsen, Lars, Edelmann, Reidunn Jetne, Krüger, Stig, Diéguez-Hurtado, Rodrigo, Shah, Akshay, Stav-Noraas, Tor Espen, Renzi, Anastasia, Szymanska, Monika, Junbai Wang, Ehling, Manuel, Benedito, Rui, Kasprzycka, Monika, Bækkevold, Espen, Sundnes, Olav, Midwood, Kim S., Scott, Helge, Collas, Philippe, Siebel, Christian W., Adams, Ralf H., and Haraldsen, Guttorm

Published
2018
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50. Estudo da função do gene Delta4 na regulação da angiogénese

Author

Benedito, Rui Miguel Santos, Duarte, António José de Freitas, and Costa, Luís Filipe Lopes da

Subjects
Notch, Arteriogénese, Delta4, Angiogénese, Angiogenesis, Arteriogenesis, Desenvolvimento Vascular, Vascular Development
Abstract

Tese de Doutoramento em Ciência e Tecnologia Animal Submitted by Maria São José Lalanda Ribeiro (mlalanda@fmv.utl.pt) on 2008-12-15T18:19:13Z No. of bitstreams: 1 Tese Final FINAL Rui Benedito.pdf: 74475973 bytes, checksum: 9981c97bd0c0e39baaded719f05eb8cf (MD5) Made available in DSpace on 2008-12-15T18:19:13Z (GMT). No. of bitstreams: 1 Tese Final FINAL Rui Benedito.pdf: 74475973 bytes, checksum: 9981c97bd0c0e39baaded719f05eb8cf (MD5) Previous issue date: 2008 Este trabalho foi realizado no âmbito dos projectos: POCTI/CVT/56015/2004 - Arteriogenesis: indentification of new members of the Notch patway involved in arterial cell fate determination e POCTI/CVT/34204/99 - Use of mammalian transgenic techniques to address the function and regulation of mDelta-4. O autor recebeu uma bolsa de investigação da Fundação Ciência e Tecnologia SFRH/BD/9020/2002.

Published
2008

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