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1. Neuroprotective Effects of Hippeastrum elegans Extract: Anticholinesterase Effect In Silico and In Vivo Studies in the Scopolamine-Induced Memory Deficits Model in Rat

Author

Tavares, Juliete, Oliveira, Alfaete Vieira, de Souza Nascimento, Tyciane, de Aguiar, Mayara Sandrielly Soares, de Paiva, Jose Regis, Braz, Helyson Lucas Bezerra, Jorge, Roberta Jeanne Bezerra, Canuto, Kirley Marques, Gomes, Jessica Maria Pessoa, Benjamin, Stephen Rathinaraj, Parente, Ana Caroline Barros, Bezerra, Jessica Rabelo, and de Andrade, Geanne Matos

Published
2024
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3. List of contributors

Author

Aatiaoui, Abdelmalik El, primary, Abdelhameed, Reda M., additional, Ahmad, Rabia, additional, Arora, Charu, additional, Bano, Karina, additional, Bano, Sarvaree, additional, Benjamin, Stephen Rathinaraj, additional, Chandrawanshi, Swati, additional, Chaurasia, Himani, additional, Dagdag, Omar, additional, Danao, Kishor, additional, Daoudi, Walid, additional, Dewangan, Ranjana, additional, Dumore, Monali, additional, El-Shahat, Mahmoud, additional, Fule, Ritesh, additional, Gollavelli, Ganesh, additional, Haldhar, Rajesh, additional, Higgins, Prerna, additional, Iqbal, Naseem, additional, Jain, Bhawana, additional, Júnior, Eli José Miranda Ribeiro, additional, Kashyap, Arun Kumar, additional, Kaushal, Sandeep, additional, Khan, Usman Ali, additional, Kumar, Ranvijay, additional, Kumar, Sandeep, additional, Lamghafri, Selma, additional, Mahajan, Ujwala, additional, Mehra, Swati, additional, Mittal, Jyoti, additional, Mohamad Noh, Mohamad Firdaus, additional, Mukhrjee, Arpita, additional, Nandurkar, Deweshri, additional, Naz, Sabiha, additional, Noor, Tayyaba, additional, Pandey, Archana, additional, Pandey, Ashutosh, additional, Pandey, Avinash, additional, Patel, Jyoti, additional, Rai, Neena, additional, Rai, Nidhi, additional, Rawat, Reena, additional, Raza, Maryam, additional, Rokde, Vijayshri, additional, Sahu, Barsa, additional, Sahu, Rakesh Kumar, additional, Sahu, Reema, additional, Sahu, Sushama, additional, Sanwaria, Sunita, additional, Shaukat, Iqra, additional, Shivhare, Ruchi, additional, Shrivastava, A.K, additional, Shrivastava, Shilpi, additional, Siddiqui, Shaziya H., additional, Singh, Ajaya Kumar, additional, Soni, Sanju, additional, Srivastava, Nivedita, additional, Srivastava, Santosh Kumar, additional, Tiwari, Alka, additional, Vasudeva Rao, Bakuru, additional, Verma, Anjali, additional, Verma, Dakeshwar Kumar, additional, Vijayasri, K., additional, Yifu, Chen, additional, and Yong-Chien, Ling, additional

Published
2024
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9. Detection of Cancer Biomarker by Advanced Biosensor

Author

Benjamin, Stephen Rathinaraj, Júnior, Eli José Miranda Ribeiro, Gerstman, Bernard S., Editor-in-Chief, Aizawa, Masuo, Series Editor, Austin, Robert H., Series Editor, Barber, James, Series Editor, Berg, Howard C., Series Editor, Callender, Robert, Series Editor, Feher, George, Series Editor, Frauenfelder, Hans, Series Editor, Giaever, Ivar, Series Editor, Joliot, Pierre, Series Editor, Keszthelyi, Lajos, Series Editor, King, Paul W., Series Editor, Lazzi, Gianluca, Series Editor, Lewis, Aaron, Series Editor, Lindsay, Stuart M., Series Editor, Liu, Xiang Yang, Series Editor, Mauzerall, David, Series Editor, Mielczarek, Eugenie V., Series Editor, Niemz, Markolf, Series Editor, Parsegian, V. Adrian, Series Editor, Powers, Linda S., Series Editor, Prohofsky, Earl W., Series Editor, Rostovtseva, Tatiana K., Series Editor, Rubin, Andrew, Series Editor, Seibert, Michael, Series Editor, Tao, Nongjian, Series Editor, Thomas, David, Series Editor, Malviya, Rishabha, editor, and Sundram, Sonali, editor

Published
2023
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12. Contributors

Author

Adhikari, Arpita, primary, Alanalp, Mine Begum, additional, Aydın, Elif Burcu, additional, Aydın, Muhammet, additional, Azad, Abul Kalam, additional, Baig, Mirza Shahed, additional, Balaji, D., additional, Bavage, Shyamlila B., additional, Benjamin, Stephen Rathinaraj, additional, Berrada, Mohammed, additional, Bhattacharya, Tanima, additional, Bhuvaneswari, V., additional, Camlibel, Nurhan Onar, additional, Chakraborty, Sarit, additional, Chalivendra, Vijaya, additional, Chattopadhyay, Dipankar, additional, Chaus, Wajid N., additional, Chopra, Hitesh, additional, Cochrane, Cedric, additional, Damiri, Fouad, additional, Das, Madhurima, additional, Das, Narayan Chandra, additional, Das, Poushali, additional, Das, Tushar Kanti, additional, De, Sriparna, additional, Dogu, Merve, additional, Durmus, Ali, additional, Dutra, Rosa Fireman, additional, Gaiji, Houda, additional, Ganguly, Sayan, additional, Gebretsadik, Abbay, additional, Gedanken, Aharon, additional, Ghatak, Avishek, additional, Ghosh, Prosenjit, additional, Ghosh, Suman Kumar, additional, Gupta, Akanksha, additional, Haftu, Mamu, additional, Jadhav, Prerana Badrinath, additional, Kaur, Damandeep, additional, Kaur, Manpreet, additional, Kaur, Navneet, additional, Khan, Shamim Ahmed, additional, Khan, Sharuk L., additional, Koncar, Vladan, additional, Kottiyatil, Abhilash J., additional, Lazim, Nurul Asmak Md, additional, Madhavan, K., additional, Majhi, Abhisek, additional, Majid, A.M.S. Abdul, additional, Maruthapandi, Moorthy, additional, Mozafari, M.R., additional, Muhamad, Ida Idayu, additional, Murthy, H.C. Ananda, additional, Nath, Jyotishka, additional, Nath, Pinku Chandra, additional, Naveen, V., additional, Nemera, Tesfaye, additional, Orasugh, Jonathan Tersur, additional, Parameswaranpillai, Jyotishkumar, additional, Paul, Pijush, additional, Porkodi, P., additional, Pramanik, Amit, additional, Rajabzadeh, Amin Reza, additional, Rajeshkumar, L., additional, Ramesh, M., additional, Ravikumar, C.R., additional, Roy, Biplab, additional, Saravanan, Arumugam, additional, Sengupta, Bratin, additional, Sezgintürk, Mustafa Kemal, additional, Siddiqui, Falak A., additional, Singh, Narinder, additional, Srinivasan, Seshasai, additional, Sultana, Rokeya, additional, Sunil, Sheeja, additional, and Vikhe, Sunayana Rahul, additional

Published
2023
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15. Chemistry, Biological Activities, and Uses of Carnauba Wax

Author

Junior, Eli José Miranda Ribeiro, Stephen, Joy Ruby Violet, Muthuvel, Murugan, Roy, Amitava, Rodrigues, Patrícia de Araújo, Mendonça Filho, Marajá João Alves de, Araújo Teixeira, Renato, Barbosa, Antony de Paula, Benjamin, Stephen Rathinaraj, Mérillon, Jean-Michel, Series Editor, Ramawat, Kishan Gopal, Series Editor, and Murthy, Hosakatte Niranjana, editor

Published
2022
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20. List of contributors

Author

Antonacci, Amina, primary, Arduini, Fabiana, additional, Begum, Shahani, additional, Benjamin, Stephen Rathinaraj, additional, Chakraborty, Joydeep, additional, Chang, Seung-Cheol, additional, Churi, Hardik, additional, Das, Jayashankar, additional, Das, Kajari, additional, Das, Trupti R., additional, Dave, Aditya, additional, Dave, Shivani, additional, Dave, Sushma, additional, de Andrade, Geanne Matos, additional, de Souza Nascimento, Tyciane, additional, Dhanalakshmi, M., additional, Gadnayak, Ayushman, additional, Garhnayak, Loknath, additional, Garhnayak, Mirna, additional, Ghorbanizamani, Faezeh, additional, Goksel, Tuncay, additional, Goswami, Swati, additional, Govender, Penny P., additional, Kamat, Vivek A., additional, Khan, Fahmida, additional, Kumar, Vijay, additional, Kumar Kar, Aswini, additional, Mahapatra, Abhijita, additional, Maharshi, Anjisha, additional, Mohanraj, Remya, additional, Mohanty, Jatindra Nath, additional, Mohanty, Padmaja, additional, Mohapatra, Abhijita, additional, Moharana, Maheswata, additional, Moulahoum, Hichem, additional, Nayak, Ananya, additional, Oriá, Reinaldo Barreto, additional, Panda, Sangram, additional, Pandya, Medha, additional, Panwar, Rohan, additional, Patra, Santanu, additional, Pattanayak, Subrat Kumar, additional, Paudyal, Janak, additional, Radhakrishnan, S., additional, Rath, Shakti, additional, Roque, Cássia Rodrigues, additional, Roy, Pragyan, additional, Sahoo, Maheswata, additional, Sahoo, Pradyumna, additional, Sahoo, Swayamprabha, additional, Samal, Priyanka, additional, Santhamoorthy, Madhappan, additional, Scognamiglio, Viviana, additional, Shah, Sejal, additional, Sharma, Richa, additional, Shukla, Sudheesh K., additional, Thirumalai, Dinakaran, additional, Thirupathi, Kokila, additional, Timur, Suna, additional, Turhan, Kutsal, additional, and Zihnioglu, Figen, additional

Published
2022
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22. Chemistry, Biological Activities, and Uses of Carnauba Wax

Author

Junio, Eli José Miranda Ribeiro, primary, Stephen, Joy Ruby Violet, additional, Muthuvel, Murugan, additional, Roy, Amitava, additional, Rodrigue, Patrícia de Araújo, additional, Mendonça Filho, Marajá João Alves de, additional, Araújo Teixeira, Renato, additional, Barbosa, Antony de Paula, additional, and Benjamin, Stephen Rathinaraj, additional

Published
2021
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36. Nanosensors

Author

Benjamin, Stephen Rathinaraj, primary, Ribeiro Junior, Eli José Miranda, additional, Thirumavalavan, Vennilavan, additional, and Paula Barbosa, Antony, additional

Published
2022
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38. The Phytochemical Composition of Medicinal Plants : Brazilian Semi-Arid Region (Caatinga)

Author

Benjamin, Stephen Rathinaraj, Muthuvel, Murugan, Saravanabhavan, Sudarsini, and Da Ponte, Iago Almeida

Subjects
Science / Life Sciences / Biochemistry
Abstract

Carnauba wax, the most important vegetable wax under the economic and extracted from the leaves of the carnauba (Copernicia prunifera (Miller) H. E. Moore), is extensively applied in food due to its physiochemical characteristics with a majority of esters. p-Methoxycinnamic acid diesters obtained from the ceriferous powder of carnauba wax (PCO-C) have been associated with biological actions. However, being a versatile product, many types of research have been carried out seeking to expand the possibilities of applications of this raw material. Furthermore, different experimental studies on the pharmacological activities have also been undertaken in recent years and have tested various biological activities, such as hypolipidemic, hypocholesterolemic and hypoglycemic effects in mice. Therefore, in this book chapter, it is reviewing the development of a process of extraction of 4-hydroxycinnamic acid diesters of carnauba wax powder and investigates their biological actions and physical and chemical characteristics.

Published
2022

39. Contributors

Author

Abady, Mariam M., Abdolshahi, Anna, Adefusika Adekoya, Mathew, Adetunji, Charles Oluwaseun, Ajai, Alexander, (Ikechuku), Akhor, Sadiq, (Oshoke), Akram, Wasim, Arya, Prabha, Banerjee, Mamoni, Benjamin, Stephen Rathinaraj, Bereli, Nilay, Bhattu, Monika, Çalışır, Merve, Çimen, Duygu, Dandapat, Anirban, Denizli, Adil, Dhara, Santanu, Dutta, P K, Ebrahimi, Arezoo, Eric, Olori, Erkek, Muhammed, Eziukwu, Chinenye, Geetanjali, Hasan, K. M. Faridul, Imtiaz, Sahar, Imtiaz, Sila, Inobeme, Abel, Inobeme, Jonathan, Joshi, Ramakant, Kashyap, Vineeta, Kaur, Noorkamal, Kaurav, Monika, Kaushik, Ajeet Kumar, Kiran, Kumai, Kumar, Addanki P., Kumar, Ganesh, Kumar, Krishan, Kumar, Santosh, Kumar L, Ram Sunil, Liu, Xiaoyi, Mahajan, Umesh R., Maliki, Munirat, Manchikanti, Padmavati, Mathew, John Tsado, Mhaske, Shashank T., Minz, Sunita, Mishra, Biswajit, Mission, Elaine Gabutin, Mohammed, Dina Mostafa, Mohanty, Jyoti Darsan, Mongia, Pooja, Nagpure, Gunjan, Natrajan, Arunadevi, Ojha, Ankur, Olugbemi, Olaniyan, Özgür, Erdoğan, Pande, Veena, Pant, Megha, Parimi, Jhansi Lakshmi, Pinheiro, Alexandre Gonçalves, Poonia, Ekta, Prabhakar, Pawan, Pradhan, Madhulika, Raj, Rakesh, Ranga, Narender, Ranga, Rohit, Rani, Roopa, Rathee, Shweta, Júnior, Eli José Miranda Ribeiro, Sahu, Kantrol Kumar, Sand, Arpit, Shaba, Elija, (Yanda), Sharma, Srishti, da Silva, Marcos Túlio, Singh, Jay, Singh, Kamana, Singh, Kshitij RB, Singh, Namrata, Singh, Ram, Singh, Ravindra Pratap, Singh, Shalinee, Soni, Shikha Kapil, Tampoc, Andrew Lambert M., Thapa, Sushma, Tiwari, Anurag, Tiwari, Ashish, Topçu, Aykut Arif, Tuteja, Jaya, Verma, Meenakshi, Wei, Shaofeng, and Yadav, Krishna

Published
2024
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41. Current and Prospective of Breast Cancer Biomarkers

Author

Benjamin, Stephen Rathinaraj and Lima, Fabio De

Subjects
Science / Chemistry
Abstract

Biomarkers have shown great promise over the past decade the process of drug development more effective and have become an integral part of diagnosis of diseases. Biosensors were integrated with biomarker detection and point-of-care detection for signal amplification, high specificity and sensitivity, rapid response time, low cost, simplicity and multi-analytical testing. In order to detect more sensitively, these particular biomarkers have been explored with the possibility of real-time measurements in order to develop simple and compact systems which can analyze complex specimens. Various biosensors including electrochemical biosensors have recently been developed based on disease-specific biomarkers in the diagnosis of cancer disease. The main objective of the book chapter is to review research with new materials/methods in electrochemical biosensing techniques to detection of breast cancer biomarkers and evaluating latest techniques for detection of important analytes in real samples. In this book chapter, the recent development of electrochemical biosensors of breast cancer biomarkers will be reviewed. Furthermore, recent and future trend application of breast cancer biomarkers will be discussed.

Published
2019

42. Carnauba wax uses in food – A review

Author

de Freitas, Claisa Andréa Silva, primary, de Sousa, Paulo Henrique Machado, additional, Soares, Denise Josino, additional, da Silva, José Ytalo Gomes, additional, Benjamin, Stephen Rathinaraj, additional, and Guedes, Maria Izabel Florindo, additional

Published
2019
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43. Ethnobotanic, phytochemical uses and ethnopharmacological profile of genus Cnidoscolus spp. (Euphorbiaceae): A comprehensive overview

Author

Moura, Luiz Francisco Wemmenson Gonçalves, primary, da Silva Neto, João Xavier, additional, Lopes, Tiago Deiveson Pereira, additional, Benjamin, Stephen Rathinaraj, additional, Brito, Fernando César Rodrigues, additional, Magalhães, Francisco Ernani Alves, additional, Florean, Eridan Orlando Pereira Tramontina, additional, de Sousa, Daniele de Oliveira Bezerra, additional, and Guedes, Maria Izabel Florindo, additional

Published
2019
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45. Hypolipidemic activity of P-methoxycinnamic diester (PCO-C) isolated from Copernicia prunífera against Triton WR-1339 and hyperlipidemic diet in mice

Author

Arruda Filho, Antônio Casella V., Rodrigues, P. A. S., Benjamin, Stephen Rathinaraj, Paim, Raquel Teixeira Terceiro, Holanda, M. O., Silva, J. Y. G., Milo, T. S., Vieira, I. G. P., Queiroz, Maria Goretti Rodrigues de, and Guedes, M. I. F.

Subjects
Dislipidemias, Dyslipidemias
Abstract

Carnauba wax is extracted from the leaves of the Copernicia prunífera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia prunífera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and triglycerides were significantly reduced plasma levels in PCO-C at the dose of 100 mg/kg in a model of acute and chronic dyslipidemia. Histological studies showed that PCO-C has no hepatotoxic effect and reduces hepatic steatosis in animals that consumed hyperlipidemic ration. Thus, it was concluded that PCO-C isolated from Copernicia Prunifera was effective in reducing total cholesterol and triglyceride levels in both dyslipidemia induction models. The finding indicates that PCO-C might be beneficial in treatment of hyperlipidemia and atherosclerosis.

Published
2017

46. Corrigendum to 'Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia'

Author

Paim, Raquel Teixeira Terceiro, Benjamin, Stephen Rathinaraj, Rondina, Davide, Marques, Márcia Maria Mendes, Viana, Daniel de Araújo, Gonzaga, Maria Leônia da Costa, Vieira, Ícaro Gusmão Pinto, Mendes, Francisca Noélia Pereira, Rodrigues, Paula Alves Salmito, and Guedes, Maria Izabel Florindo

Subjects
Complementary and alternative medicine, lcsh:Other systems of medicine, Corrigendum, lcsh:RZ201-999
Abstract

The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of

Published
2017

47. Development and evaluation of electro analytical methods of antioxidant capacity

Author

Benjamin, Stephen Rathinaraj, Gil, Eric de Souza, Marreto, Ricardo Neves, Ghedini, Paulo César, Colmati Junior, Flavio, and Oliveira, Severino Carlos Bezerra de

Subjects
Atividade antioxidante, Carbon paste electrode, Antioxidant activity, Voltametria de pulso diferencial, Biossensor, Differential pulse voltammetry, Eletrodo de pasta de carbono, Biosensor, DPPH, FARMACIA [CIENCIAS DA SAUDE]
Abstract

Neste trabalho foram realizados ensaios de atividade antioxidante em amostras de acerola, café, bem como de outros extratos secos de frutos vermelhos, empregando-se eletrodos convencionais de pasta de carbono (EPC), bem como biossensores de EPC modificados com extrato bruto de lacase (EPCL), partindo de Pycnoporus sanguineus (atividade 2019 U L-1) em diferentes composições com e sem uso de agentes modificadores, visando avaliar melhor sistema. Para além consolidar o uso de métodos eletroanalíticos, i.e. voltametria cíclica (VC), voltametria de onda quadrada (VOQ) e pulso diferencial (VDP), na análise de produtos naturais, seja para avaliar perfil antioxidante, seja para inferir sobre classes de antioxidantes presentes nas amostras, pode-se neste estudo avaliar o papel de diferentes agentes modificadores. O biossensor constituído de nanotubos de carbono ativado com DNA (EPCL-DNA) apresentou o melhor nível de sensibilidade 0,0549 μA/μM e um limite de detecção (LOD) de 1,2 μM no intervalo de concentração de 20-140 μM de rutina. Além disso, o biossensor mostrou ter uma excelente estabilidade ao longo de 10 dias e reprodutibilidade (RSD < 5%). Para a avaliação da sua capacidade de detecção, os resultados obtidos foram comparados com outras técnicas eletroanalíticas usando como base analítica amostras do café comercial de diferentes países. O EPCL-DNA foi empregado para determinar a quantidade de fenol total nas amostras de café (expressa pelo equivalente de rutina). Com isso, foi possível propor os EPCL como ferramenta analítica para a detecção dos fenóis. A determinação quantitativa desses compostos foi realizada através da construção de curvas de calibração para VPD e o índice eletroquímico foi proposto para estimar o potencial antioxidante entre diferentes amostras. Também foi investigado o uso de EPC para o controle de qualidade de diferentes produtos obtidos a partir da acerola, empregando VPD para a quantificação de ácido ascórbico (AA) em todas as amostras, onde os limites de detecção (LD) e o Limite de quantificação (LQ) foi de 0,31 e 0,96 μM respectivamente e com uma excelente taxa de recuperação entre 97,4-102,2%. Os ensaios de DPPH foram utilizados para comparar a atividade antioxidante nas amostras de café e acerola. O método de Folin-Ciocalteu foi usado para estimar a atividade antioxidante da rutina nas amostras de café. Pode concluir-se que os métodos propostos apresentaram vantagens, como a simplicidade na preparação das amostras e a rapidez do ensaio da capacidade antioxidante. This study investigated the antioxidant activity using biosensors based on carbon paste electrode (CPE) modified with crude extract of laccase (Pycnoporus sanguineus, activity 2019 U L-1) in different compositions. The biosensor consists of carbon nanotubes activated with DNA (CPEL-DNA: CN) showed the best sensitivity level, 0.0549 μA / μM and 1.2 uM detection limit (LOD) in the concentration range of 20-140 μM of rutin. This biosensor showed excellent stability over 10 days and reproducibility (RSD

Published
2016

48. Antihypercholesterolemic Effects of Fruit Aqueous Extract ofCopernicia prunifera(Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia

Author

Paim, Raquel Teixeira Terceiro, primary, Benjamin, Stephen Rathinaraj, additional, Rondina, Davide, additional, Marques, Márcia Maria Mendes, additional, Viana, Daniel de Araújo, additional, Gonzaga, Maria Leônia da Costa, additional, Vieira, Ícaro Gusmão Pinto, additional, Mendes, Francisca Noélia Pereira, additional, Rodrigues, Paula Alves Salmito, additional, and Guedes, Maria Izabel Florindo, additional

Published
2017
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50. Characterization of Cnidoscolus quercifolius Pohl bark root extract and evaluation of cytotoxic effect on human tumor cell lines.

Author

Paredes, Paulo Fernando Machado, de Morais, Selene Maia, Brito, Fernando César Rodrigues, Gonçalves Moura, Luiz Francisco Wemmenson, de Araújo Rodrigues, Patrícia, Benjamin, Stephen Rathinaraj, Magalhães, Francisco Ernani Alves, Tramontina Florean, Eridan Orlando Pereira, and Guedes, Maria Izabel Florindo

Subjects
CNIDOSCOLUS, CANCER cells, HIGH performance liquid chromatography, NUCLEAR magnetic resonance spectroscopy, ANTICARCINOGENIC agents
Abstract

Objective: To evaluate the chemical components of active extract from Cnidoscolus quercifolius root bark and its cytotoxic potential against several tumor strains. Methods: The highperformance liquid chromatography with diode-array detection and 1H and 13C nuclear magnetic resonance spectroscopy of the extract were used to distinguish the existence of possible functional groups in the root bark extract. The in vitro cytotoxic activity of methanol extract on human colon cancer cell lines was evaluated using OVCAR-8, SF-295, HCT-116, HL-60 strains and the samples were assessed by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide method. Results: The analysis of nuclear magnetic spectra of the active chloroform fraction revealed the presence of absorptions bands correspondent to a mixture of favelines such as neofavelanone, deoxofaveline or methyl-faveline, which structures were confirmed by ultraviolet spectra upon high-performance liquid chromatography with diode-array detection analysis. The active fraction showed cytotoxic effects in the tested strains, HCT-116, SF-295, OVCAR-8 and HL-60 cells with IC50 of 72 hours ranging from 4.95 to 15.23 µg/mL. Conclusions: The results suggest that the substances present in faveleira (Cnidoscolus quercifolius) root bark extract have a cytotoxic potential against several tumor lines, showing a broader antitumour potential, and in addition no adverse to healthy cells. Therefore, the root bark extract of Cnidoscolus quercifolius has a possibility of use for anticarcinogenic therapies. [ABSTRACT FROM AUTHOR]

Published
2018
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